Table SI. The predicted targets of miR-221-3p with TargetScan database.

Target Representative transcript Gene name

VAPB ENST00000395802.3 VAMP (vesicle-associated membrane )-associated protein B and C TMSB15B ENST00000540220.1 Thymosin beta 15B TFG ENST00000240851.4 TRK-fused gene HECTD2 ENST00000371667.1 HECT domain containing E3 ubiquitin protein ligase 2 CLVS2 ENST00000275162.5 Clavesin 2 PAIP1 ENST00000514514.1 poly(A) binding protein interacting protein 1 MIDN ENST00000591446.2 Midnolin AGFG1 ENST00000310078.8 ArfGAP with FG repeats 1 HMBOX1 ENST00000397358.3 containing 1 MYLIP ENST00000349606.4 regulatory light chain interacting protein SEC62 ENST00000337002.4 SEC62 homolog (S. cerevisiae) TMCC1 ENST00000432054.2 Transmembrane and coiled-coil domain family 1 PHACTR4 ENST00000373839.3 Phosphatase and regulator 4 AIDA ENST00000340020.6 Axin interactor, dorsalization associated BEAN1 ENST00000299694.8 Brain expressed, associated with NEDD4, 1 AMMECR1 ENST00000262844.5 Alport syndrome, midface hypoplasia and elliptocytosis chro- mosomal region gene 1 EIF3J ENST00000261868.5 Eukaryotic translation initiation factor 3, subunit J SMARCA5 ENST00000283131.3 SWI/SNF related, actin dependent regulator of chromatin, subfamily a, member 5 TCF12 ENST00000267811.5 12 PNO1 ENST00000263657.2 Partner of NOB1 homolog (S. cerevisiae) ZBTB37 ENST00000367701.5 and BTB domain containing 37 FOS ENST00000303562.4 FBJ murine osteosarcoma viral oncogene homolog ZNF385A ENST00000551109.1 Zinc finger protein 385A ATAD2B ENST00000238789.5 ATPase family, AAA domain containing 2B NRK ENST00000243300.9 Nik related kinase IRF2 ENST00000393593.3 Interferon regulatory factor 2 PLCL2 ENST00000418129.2 Phospholipase C-like 2 SOCS3 ENST00000330871.2 Suppressor of cytokine signaling 3 MIER3 ENST00000381226.3 Mesoderm induction early response 1, family member 3 PIK3R1 ENST00000521381.1 Phosphoinositide-3-kinase, regulatory subunit 1 (alpha) SNCB ENST00000310112.3 Synuclein, beta RNF4 ENST00000511859.1 Ring finger protein 4 SYT10 ENST00000228567.3 Synaptotagmin X TOX ENST00000361421.1 Thymocyte selection-associated high mobility group box CRKL ENST00000354336.3 v-crk avian sarcoma virus CT10 oncogene homolog-like PTS ENST00000525803.1 6-pyruvoyltetrahydropterin synthase DDIT4 ENST00000307365.3 DNA-damage-inducible transcript 4 CHSY1 ENST00000254190.3 Chondroitin sulfate synthase 1 BBC3 ENST00000341983.4 BCL2 binding component 3 PCDHA2 ENST00000526136.1 Protocadherin alpha 2 DYNC1LI2 ENST00000258198.2 Dynein, cytoplasmic 1, light intermediate chain 2 DCAF7 ENST00000310827.4 DDB1 and CUL4 associated factor 7 CDKN1C ENST00000414822.3 Cyclin-dependent kinase inhibitor 1C (p57, Kip2) RBM24 ENST00000379052.5 RNA binding motif protein 24 KIF16B ENST00000354981.2 Kinesin family member 16B EMX2 ENST00000442245.4 Empty spiracles homeobox 2 FOXN2 ENST00000340553.3 Forkhead box N2 PDGFA ENST00000354513.5 Platelet-derived growth factor alpha polypeptide GTF2B ENST00000370500.5 General transcription factor IIB NLK ENST00000407008.3 Nemo-like kinase CASZ1 ENST00000377022.3 Castor zinc finger 1 ZFPM2 ENST00000407775.2 Zinc finger protein, FOG family member 2 WDR47 ENST00000400794.3 WD repeat domain 47 DMRT3 ENST00000190165.2 Doublesex and mab-3 related transcription factor 3 FAM199X ENST00000493442.1 Family with sequence similarity 199, X-linked NIPAL4 ENST00000311946.7 NIPA-like domain containing 4 Table SI. Continued.

Target gene Representative transcript Gene name

CD4 ENST00000011653.4 CD4 molecule ATXN1 ENST00000244769.4 Ataxin 1 THBS1 ENST00000260356.5 Thrombospondin 1 ARHGAP42 ENST00000524892.2 Rho GTPase activating protein 42 NDST3 ENST00000296499.5 N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 3 CNOT2 ENST00000229195.3 CCR4-NOT transcription complex, subunit 2 GNAI3 ENST00000369851.4 Guanine nucleotide binding protein (), alpha inhib- iting activity polypeptide 3 BEND4 ENST00000504360.1 BEN domain containing 4 KPNA1 ENST00000344337.6 Karyopherin alpha 1 (importin alpha 5) FLJ00388 ENST00000594280.1 CYR61 ENST00000451137.2 Cysteine-rich, angiogenic inducer, 61 C2orf91 ENST00000378711.2 2 open reading frame 91 ZSWIM4 ENST00000254323.2 Zinc finger, SWIM-type containing 4 MYO10 ENST00000513610.1 Myosin X PDE3A ENST00000359062.3 Phosphodiesterase 3A, cgmp-inhibited IPO7 ENST00000379719.3 Importin 7 H3F3A ENST00000366813.1 H3 histone, family 3A MYEF2 ENST00000324324.7 Myelin expression factor 2 DKK2 ENST00000285311.3 Dickkopf WNT signaling pathway inhibitor 2 PLCXD3 ENST00000377801.3 Phosphatidylinositol-specific phospholipase C, X domain containing 3 ADAM22 ENST00000398204.4 ADAM metallopeptidase domain 22 LHX8 ENST00000294638.5 LIM homeobox 8 CTCF ENST00000264010.4 CCCTC-binding factor (zinc finger protein) RFX3 ENST00000382004.3 Regulatory factor X, 3 (influences HLA class II expression) MARCKS ENST00000368635.4 Myristoylated alanine-rich C substrate CAND1 ENST00000545606.1 Cullin-associated and neddylation-dissociated 1 TERF2 ENST00000254942.3 Telomeric repeat binding factor 2 PCDHA7 ENST00000525929.1 Protocadherin alpha 7 PCDHA5 ENST00000529859.1 Protocadherin alpha 5 PCDHA12 ENST00000398631.2 Protocadherin alpha 12 POGZ ENST00000392723.1 Pogo transposable element with ZNF domain IKZF4 ENST00000262032.5 IKAROS family zinc finger 4 (Eos) PCDHA1 ENST00000504120.2 Protocadherin alpha 1 PCDHA6 ENST00000529310.1 Protocadherin alpha 6 PCDHA4 ENST00000530339.1 Protocadherin alpha 4 PCDHA9 ENST00000532602.1 Protocadherin alpha 9 PCDHA10 ENST00000307360.5 Protocadherin alpha 10 PCDHA11 ENST00000398640.2 Protocadherin alpha 11 PCDHA3 ENST00000522353.2 Protocadherin alpha 3 PCDHA8 ENST00000531613.1 Protocadherin alpha 8 PCDHA13 ENST00000289272.2 Protocadherin alpha 13 PCDHAC1 ENST00000253807.2 Protocadherin alpha subfamily C, 1 MSL1 ENST00000398532.4 Male-specific lethal 1 homolog (Drosophila) SLC16A6 ENST00000327268.4 Solute carrier family 16, member 6 TRPS1 ENST00000395715.3 Trichorhinophalangeal syndrome I SH3BP4 ENST00000392011.2 SH3-domain binding protein 4 PCDHAC2 ENST00000289269.5 Protocadherin alpha subfamily C, 2 SEC23IP ENST00000369075.3 SEC23 interacting protein WASF2 ENST00000536657.1 WAS protein family, member 2 HNRNPA3 ENST00000411529.2 Heterogeneous nuclear ribonucleoprotein A3 HIPK1 ENST00000369558.1 Homeodomain interacting protein kinase 1 MITF ENST00000328528.6 Microphthalmia-associated transcription factor SLC25A37 ENST00000519973.1 Solute carrier family 25 (mitochondrial iron transporter), member 37 GPR12 ENST00000405846.3 G protein-coupled 12 TIPARP ENST00000295924.7 TCDD-inducible poly(ADP-ribose) polymerase KDSR ENST00000406396.3 3-ketodihydrosphingosine reductase Table SI. Continued.

Target gene Representative transcript Gene name

RUNX2 ENST00000371432.3 Runt-related transcription factor 2 LRFN2 ENST00000338305.6 Leucine rich repeat and fibronectin type III domain containing 2 AMIGO1 ENST00000369864.4 Adhesion molecule with Ig-like domain 1 MEX3A ENST00000532414.2 Mex-3 RNA binding family member A ZFAND5 ENST00000237937.3 Zinc finger, AN1-type domain 5 CDH2 ENST00000269141.3 Cadherin 2, type 1, N-cadherin (neuronal) TTBK2 ENST00000267890.6 Tau tubulin kinase 2 AP3M1 ENST00000355264.4 Adaptor-related protein complex 3, mu 1 subunit HNRNPA0 ENST00000314940.4 Heterogeneous nuclear ribonucleoprotein A0 EIF1 ENST00000469257.1 Eukaryotic translation initiation factor 1 SOX11 ENST00000322002.3 SRY (sex determining region Y)-box 11 AGO4 ENST00000373210.3 Argonaute RISC catalytic component 4 BMI1 ENST00000376663.3 BMI1 polycomb ring finger oncogene HNRNPH3 ENST00000265866.7 Heterogeneous nuclear ribonucleoprotein H3 (2H9) WDR37 ENST00000358220.1 WD repeat domain 37 LYSMD1 ENST00000368908.5 LysM, putative peptidoglycan-binding, domain containing 1 PPP6C ENST00000373547.4 Protein phosphatase 6, catalytic subunit PKIA ENST00000396418.2 Protein kinase (camp-dependent, catalytic) inhibitor alpha C16orf45 ENST00000300006.4 open reading frame 45 GPBP1 ENST00000424459.3 GC-rich promoter binding protein 1 RNF44 ENST00000274811.4 Ring finger protein 44 COMMD3-BMI1 ENST00000602390.1 COMMD3-BMI1 readthrough PDIK1L ENST00000374271.4 PDLIM1 interacting kinase 1 like SOCS1 ENST00000332029.2 Suppressor of cytokine signaling 1 FRY ENST00000380250.3 Furry homolog (Drosophila) LPPR1 ENST00000374874.3 Lipid phosphate phosphatase-related protein type 1 PTPN3 ENST00000412145.1 Protein tyrosine phosphatase, non-receptor type 3 YTHDC1 ENST00000344157.4 YTH domain containing 1 FAM196B ENST00000377365.3 Family with sequence similarity 196, member B NANOS1 ENST00000425699.1 Nanos homolog 1 (Drosophila) NIPBL ENST00000448238.2 Nipped-B homolog (Drosophila) UBE2N ENST00000550657.1 Ubiquitin-conjugating enzyme E2N FNDC3A ENST00000492622.2 Fibronectin type III domain containing 3A PDZRN4 ENST00000298919.7 PDZ domain containing ring finger 4 GALNT18 ENST00000227756.4 UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 18 FAM167A ENST00000284486.4 Family with sequence similarity 167, member A AGFG2 ENST00000262935.4 ArfGAP with FG repeats 2 CTIF ENST00000256413.3 CBP80/20-dependent translation initiation factor SRSF2 ENST00000392485.2 Serine/arginine-rich splicing factor 2 CXCR5 ENST00000292174.4 Chemokine (C-X-C motif) receptor 5 EIF4E3 ENST00000425534.3 Eukaryotic translation initiation factor 4E family member 3 ARHGAP28 ENST00000419673.2 Rho GTPase activating protein 28 MAGI1 ENST00000330909.8 Membrane associated guanylate kinase, WW and PDZ domain containing 1 LUC7L3 ENST00000505658.1 LUC7-like 3 (S. cerevisiae) TBC1D19 ENST00000264866.4 TBC1 domain family, member 19 KIAA0430 ENST00000396368.3 KIAA0430 CHD8 ENST00000430710.3 Chromodomain helicase DNA binding protein 8 USP49 ENST00000394253.3 Ubiquitin specific peptidase 49 CDH4 ENST00000360469.5 Cadherin 4, type 1, R-cadherin (retinal) GATA4 ENST00000335135.4 GATA binding protein 4 CDC5L ENST00000371477.3 Cell division cycle 5-like ZNF652 ENST00000362063.2 Zinc finger protein 652 MAPK10 ENST00000395169.3 Mitogen-activated protein kinase 10 QKI ENST00000392127.2 QKI, KH domain containing, RNA binding RGS17 ENST00000367225.2 Regulator of G-protein signaling 17 HEG1 ENST00000311127.4 Heart development protein with EGF-like domains 1 CNOT6 ENST00000393356.1 CCR4-NOT transcription complex, subunit 6 Table SI. Continued.

Target gene Representative transcript Gene name

C16orf52 ENST00000542527.2 Chromosome 16 open reading frame 52 TRPM3 ENST00000377110.3 Transient receptor potential cation channel, subfamily M, member 3 TIMP2 ENST00000585421.1 TIMP metallopeptidase inhibitor 2 ELK4 ENST00000357992.4 ELK4, ETS-domain protein (SRF accessory protein 1) IGF2BP2 ENST00000382199.2 Insulin-like growth factor 2 mrna binding protein 2 KSR1 ENST00000398988.3 Kinase suppressor of ras 1 PHF12 ENST00000577226.1 PHD finger protein 12 KANSL1 ENST00000574590.1 KAT8 regulatory NSL complex subunit 1 FRAT2 ENST00000371019.2 Frequently rearranged in advanced T-cell lymphomas 2 TRABD2B ENST00000606738.2 TraB domain containing 2B PEG3 ENST00000423103.2 Paternally expressed 3 PPP2R5E ENST00000337537.3 Protein phosphatase 2, regulatory subunit B', epsilon isoform PTBP3 ENST00000374257.1 Polypyrimidine tract binding protein 3 ELP4 ENST00000395934.2 Elongator acetyltransferase complex subunit 4 PAK1 ENST00000278568.4 p21 protein (Cdc42/Rac)-activated kinase 1 DGKH ENST00000261491.5 Diacylglycerol kinase, eta CAMK1D ENST00000378847.3 Calcium/calmodulin-dependent protein kinase ID BCL2L11 ENST00000393256.3 BCL2-like 11 (apoptosis facilitator) FBN2 ENST00000262464.4 Fibrillin 2 FAM110B ENST00000361488.3 Family with sequence similarity 110, member B TNRC6C ENST00000335749.4 Trinucleotide repeat containing 6C FIGN ENST00000333129.3 Fidgetin FOXP1 ENST00000318789.4 Forkhead box P1 BRWD1 ENST00000342449.3 Bromodomain and WD repeat domain containing 1 GRM1 ENST00000392299.2 , metabotropic 1 PLD5 ENST00000536534.2 Phospholipase D family, member 5 TMEM132B ENST00000299308.3 Transmembrane protein 132B COL4A4 ENST00000396625.3 Collagen, type IV, alpha 4 MED1 ENST00000300651.6 Mediator complex subunit 1 PURA ENST00000331327.3 Purine-rich element binding protein A SNX29 ENST00000566228.1 Sorting nexin 29 MON2 ENST00000546600.1 MON2 homolog (S. cerevisiae) NFAT5 ENST00000354436.2 Nuclear factor of activated T-cells 5, tonicity-responsive ETS2 ENST00000360214.3 v-ets avian erythroblastosis virus E26 oncogene homolog 2 SPTSSA ENST00000298130.4 Serine palmitoyltransferase, small subunit A CMTM4 ENST00000394106.2 CKLF-like MARVEL transmembrane domain containing 4 BCL11B ENST00000357195.3 B-cell CLL/lymphoma 11B (zinc finger protein) SLC40A1 ENST00000261024.2 Solute carrier family 40 (iron-regulated transporter), member 1 IGF1 ENST00000337514.6 Insulin-like growth factor 1 (somatomedin C) PLEKHA6 ENST00000272203.3 Pleckstrin homology domain containing, family A member 6 RIMS4 ENST00000372851.3 Regulating synaptic membrane exocytosis 4 SRCIN1 ENST00000264659.7 SRC kinase signaling inhibitor 1 HOOK3 ENST00000307602.4 Hook microtubule-tethering protein 3 CYP7B1 ENST00000310193.3 Cytochrome P450, family 7, subfamily B, polypeptide 1 FOXP2 ENST00000408937.3 Forkhead box P2 TLE3 ENST00000558939.1 Transducin-like enhancer of split 3 (E(sp1) homolog, RREB1 ENST00000379938.2 Drosophila) ras responsive element binding protein 1 KIAA1598 ENST00000260777.10 KIAA1598 SPATA2 ENST00000289431.5 Spermatogenesis associated 2 MTERF ENST00000419292.1 Mitochondrial transcription termination factor RP11-766F14.2 ENST00000511828.1 Protein LOC285556 ITGB3 ENST00000559488.1 Integrin, beta 3 (platelet glycoprotein iiia, antigen CD61) DNAL1 ENST00000553645.2 Dynein, axonemal, light chain 1 RND2 ENST00000544533.1 Rho family GTPase 2 NBEAL1 ENST00000449802.1 Neurobeachin-like 1 NSUN4 ENST00000474844.1 NOP2/Sun domain family, member 4 ANAPC16 ENST00000299381.4 Anaphase promoting complex subunit 16 Table SI. Continued.

Target gene Representative transcript Gene name

LIFR ENST00000263409.4 Sestrin 3 SHISA9 ENST00000558583.1 Opa interacting protein 5 CASP10 ENST00000360132.3 Leucine rich repeat containing 14 TIMP3 ENST00000266085.6 Serine/arginine-rich splicing factor 7 FAM120A ENST00000333936.5 Oxidase (cytochrome c) assembly 1-like PRR14L ENST00000434485.1 Myeloid/lymphoid or mixed-lineage leukemia (trithorax ZC3H6 ENST00000343936.4 homolog, Drosophila); translocated to, 6 MEIS1 ENST00000488550.1 Suppressor of cytokine signaling 7 MPRIP ENST00000341712.4 Syntaxin 1B URI1 ENST00000392271.1 Protein tyrosine phosphatase, mitochondrial 1 SESN3 ENST00000536441.1 Transcription factor 3 OIP5 ENST00000220514.3 Drebrin-like LRRC14 ENST00000292524.1 G protein-coupled receptor 22 SRSF7 ENST00000313117.6 Leucine rich repeat containing 34 OXA1L ENST00000285848.5 Vesicle transport through interaction with t-snares 1A MLLT6 ENST00000325718.7 LLP homolog, long-term synaptic facilitation (Aplysia) Leukemia inhibitory factor receptor alpha SOCS7 ENST00000577233.1 Shisa family member 9 STX1B ENST00000215095.5 Caspase 10, apoptosis-related cysteine peptidase PTPMT1 ENST00000426530.2 TIMP metallopeptidase inhibitor 3 TCF3 ENST00000262965.5 Family with sequence similarity 120A DBNL ENST00000494774.1 Proline rich 14-like GPR22 ENST00000304402.4 Zinc finger CCCH-type containing 6 LRRC34 ENST00000446859.1 Meis homeobox 1 VTI1A ENST00000393077.2 Myosin phosphatase Rho interacting protein LLPH ENST00000266604.2 URI1, prefoldin-like chaperone Table SII. Predicted targets of miR-221-3p with the miRDB database.

Target Target Target detail rank score miRNA name Gene symbol Gene description

Details 1 100 hsa-miR-221-3p RIMS3 Regulating synaptic membrane exocytosis 3 Details 2 100 hsa-miR-221-3p GABRA1 Gamma-aminobutyric acid type A receptor alpha1 subunit Details 3 99 hsa-miR-221-3p CDKN1B Cyclin dependent kinase inhibitor 1B Details 4 98 hsa-miR-221-3p PAIP1 Poly(A) binding protein interacting protein 1 Details 5 98 hsa-miR-221-3p PANK3 Pantothenate kinase 3 Details 6 98 hsa-miR-221-3p TCF12 Transcription factor 12 Details 7 98 hsa-miR-221-3p HECTD2 HECT domain E3 ubiquitin protein ligase 2 Details 8 97 hsa-miR-221-3p RFX7 Regulatory factor X7 Details 9 97 hsa-miR-221-3p RGS6 Regulator of G protein signaling 6 Details 10 97 hsa-miR-221-3p HMBOX1 Homeobox containing 1 Details 11 96 hsa-miR-221-3p EIF5A2 Eukaryotic translation initiation factor 5A2 Details 12 95 hsa-miR-221-3p KIT KIT proto-oncogene receptor Details 13 95 hsa-miR-221-3p MIDN Midnolin Details 14 95 hsa-miR-221-3p EML6 EMAP like 6 Details 15 95 hsa-miR-221-3p CLVS2 Clavesin 2 Details 16 95 hsa-miR-221-3p GNAI3 G protein subunit alpha i3 Details 17 95 hsa-miR-221-3p GRB10 bound protein 10 Details 18 95 hsa-miR-221-3p ARHGEF38 Rho guanine nucleotide exchange factor 38 Details 19 94 hsa-miR-221-3p GRIK1 Glutamate ionotropic receptor kainate type subunit 1 Details 20 94 hsa-miR-221-3p TGS1 Trimethylguanosine synthase 1 Details 21 94 hsa-miR-221-3p RAB18 RAB18, member RAS oncogene family Details 22 94 hsa-miR-221-3p ADAM22 ADAM metallopeptidase domain 22 Details 23 94 hsa-miR-221-3p DENND1B DENN domain containing 1B Details 24 94 hsa-miR-221-3p FNIP2 Folliculin interacting protein 2 Details 25 94 hsa-miR-221-3p MYLIP Myosin regulatory light chain interacting protein Details 26 94 hsa-miR-221-3p VAPB VAMP associated protein B and C Details 27 94 hsa-miR-221-3p FNDC3A Fibronectin type III domain containing 3A Details 28 93 hsa-miR-221-3p LOC100506388 Uncharacterized LOC100506388 Details 29 93 hsa-miR-221-3p ZNF91 Zinc finger protein 91 Details 30 93 hsa-miR-221-3p WDR35 WD repeat domain 35 Details 31 93 hsa-miR-221-3p C3orf70 Chromosome 3 open reading frame 70 Details 32 93 hsa-miR-221-3p MIER3 MIER family member 3 Details 33 93 hsa-miR-221-3p GALNT3 Polypeptide N-acetylgalactosaminyltransferase 3 Details 34 93 hsa-miR-221-3p NRK Nik related kinase Details 35 93 hsa-miR-221-3p TFG TRK-fused gene Details 36 93 hsa-miR-221-3p PCMTD1 Protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 1 Details 37 92 hsa-miR-221-3p POGZ Pogo transposable element derived with ZNF domain Details 38 92 hsa-miR-221-3p RSBN1L Round spermatid basic protein 1 like Details 39 92 hsa-miR-221-3p DCUN1D1 Defective in cullin neddylation 1 domain containing 1 Details 40 92 hsa-miR-221-3p CHSY1 Chondroitin sulfate synthase 1 Details 41 92 hsa-miR-221-3p AGTPBP1 ATP/GTP binding protein 1 Details 42 92 hsa-miR-221-3p SEC62 SEC62 homolog, preprotein translocation factor Details 43 92 hsa-miR-221-3p RIT2 Ras like without CAAX 2 Details 44 92 hsa-miR-221-3p ERBB4 erb-b2 4 Details 45 92 hsa-miR-221-3p DMRT3 Doublesex and mab-3 related transcription factor 3 Details 46 92 hsa-miR-221-3p PPP3R1 Protein phosphatase 3 regulatory subunit B, alpha Details 47 92 hsa-miR-221-3p CCN1 Cellular communication network factor 1 Details 48 92 hsa-miR-221-3p NAA25 N(alpha)-acetyltransferase 25, natb auxiliary subunit Details 49 92 hsa-miR-221-3p ARF4 ADP ribosylation factor 4 Details 50 92 hsa-miR-221-3p CDH2 Cadherin 2 Details 51 92 hsa-miR-221-3p ZFPM2 Zinc finger protein, FOG family member 2 Details 52 91 hsa-miR-221-3p HNRNPH3 Heterogeneous nuclear ribonucleoprotein H3 Details 53 91 hsa-miR-221-3p KIF16B Kinesin family member 16B Details 54 91 hsa-miR-221-3p KIF20A Kinesin family member 20A Details 55 91 hsa-miR-221-3p FMR1 Fragile X mental retardation 1 Details 56 91 hsa-miR-221-3p ATXN1 Ataxin 1 Table SII. Continued.

Target Target Target detail rank score miRNA name Gene symbol Gene description

Details 57 91 hsa-miR-221-3p FOXN2 Forkhead box N2 Details 58 91 hsa-miR-221-3p MRAP2 Melanocortin 2 receptor accessory protein 2 Details 59 91 hsa-miR-221-3p CBWD5 COBW domain containing 5 Details 60 91 hsa-miR-221-3p CASZ1 Castor zinc finger 1 Details 61 91 hsa-miR-221-3p CBWD1 COBW domain containing 1 Details 62 91 hsa-miR-221-3p SUN2 Sad1 and UNC84 domain containing 2 Details 63 91 hsa-miR-221-3p CBWD6 COBW domain containing 6 Details 64 91 hsa-miR-221-3p DCAF12 DDB1 and CUL4 associated factor 12 Details 65 91 hsa-miR-221-3p VASH1 Vasohibin 1 Details 66 91 hsa-miR-221-3p TMCC1 Transmembrane and coiled-coil domain family 1 Details 67 91 hsa-miR-221-3p TP53BP2 Tumor protein binding protein 2 Details 68 91 hsa-miR-221-3p CBWD3 COBW domain containing 3 Details 69 91 hsa-miR-221-3p ETV3 ETS variant 3 Details 70 90 hsa-miR-221-3p MARK1 Microtubule affinity regulating kinase 1 Details 71 90 hsa-miR-221-3p PHACTR4 Phosphatase and actin regulator 4 Details 72 90 hsa-miR-221-3p SYT10 Synaptotagmin 10 Details 73 90 hsa-miR-221-3p PIK3R1 Phosphoinositide-3-kinase regulatory subunit 1 Details 74 90 hsa-miR-221-3p CBWD2 COBW domain containing 2 Details 75 90 hsa-miR-221-3p APOLD1 Apolipoprotein L domain containing 1 Details 76 90 hsa-miR-221-3p LHFPL2 LHFPL tetraspan subfamily member 2 Details 77 90 hsa-miR-221-3p FERMT2 Fermitin family member 2 Details 78 90 hsa-miR-221-3p KLF7 Kruppel like factor 7 Details 79 89 hsa-miR-221-3p CXCL12 C-X-C motif chemokine 12 Details 80 89 hsa-miR-221-3p CCDC18 Coiled-coil domain containing 18 Details 81 89 hsa-miR-221-3p NXPH1 Neurexophilin 1 Details 82 89 hsa-miR-221-3p BICDL1 BICD family like cargo adaptor 1 Details 83 89 hsa-miR-221-3p BCL2L11 BCL2 like 11 Details 84 89 hsa-miR-221-3p BRWD1 Bromodomain and WD repeat domain containing 1 Details 85 89 hsa-miR-221-3p C6 Complement C6 Details 86 89 hsa-miR-221-3p RFX8 RFX family member 8, lacking RFX DNA binding domain Details 87 89 hsa-miR-221-3p C6orf118 Chromosome 6 open reading frame 118 Details 88 89 hsa-miR-221-3p PPP2R2A Protein phosphatase 2 regulatory subunit Balpha Details 89 89 hsa-miR-221-3p MARF1 Meiosis regulator and mrna stability factor 1 Details 90 88 hsa-miR-221-3p FAM214A Family with sequence similarity 214 member A Details 91 88 hsa-miR-221-3p PIEZO2 Piezo type mechanosensitive component 2 Details 92 88 hsa-miR-221-3p DPH6 Diphthamine biosynthesis 6 Details 93 88 hsa-miR-221-3p PLCL2 Phospholipase C like 2 Details 94 88 hsa-miR-221-3p ZNF615 Zinc finger protein 615 Details 95 88 hsa-miR-221-3p GABRG1 Gamma-aminobutyric acid type A receptor gamma1 subunit Details 96 88 hsa-miR-221-3p CDK19 Cyclin dependent kinase 19 Details 97 88 hsa-miR-221-3p HIPK1 Homeodomain interacting protein kinase 1 Details 98 88 hsa-miR-221-3p GUCY1A2 Guanylate cyclase 1 soluble subunit alpha 2 Details 99 88 hsa-miR-221-3p WDR47 WD repeat domain 47 Details 100 87 hsa-miR-221-3p SESN3 Sestrin 3 Details 101 87 hsa-miR-221-3p USP27X Ubiquitin specific peptidase 27 X-linked Details 102 87 hsa-miR-221-3p AP3B2 Adaptor related protein complex 3 subunit beta 2 Details 103 87 hsa-miR-221-3p ESR1 1 Details 104 87 hsa-miR-221-3p TUB Tubby bipartite transcription factor Details 105 87 hsa-miR-221-3p ASPA Aspartoacylase Details 106 87 hsa-miR-221-3p SYBU Syntabulin Details 107 87 hsa-miR-221-3p CTDSPL2 CTD small phosphatase like 2 Details 108 87 hsa-miR-221-3p SBK1 SH3 domain binding kinase 1 Details 109 86 hsa-miR-221-3p DDIT4 DNA damage inducible transcript 4 Details 110 86 hsa-miR-221-3p CLRN1 Clarin 1 Details 111 86 hsa-miR-221-3p SLC4A7 Solute carrier family 4 member 7 Details 112 86 hsa-miR-221-3p TLE3 TLE family member 3, transcriptional corepressor Table SII. Continued.

Target Target Target detail rank score miRNA name Gene symbol Gene description

Details 113 86 hsa-miR-221-3p RFX3 Regulatory factor X3 Details 114 86 hsa-miR-221-3p EIF3J Eukaryotic translation initiation factor 3 subunit J Details 115 86 hsa-miR-221-3p ANKRD12 repeat domain 12 Details 116 86 hsa-miR-221-3p CREBL2 Camp responsive element binding protein like 2 Details 117 86 hsa-miR-221-3p TSPAN13 Tetraspanin 13 Details 118 86 hsa-miR-221-3p ZMYM2 Zinc finger MYM-type containing 2 Details 119 86 hsa-miR-221-3p DPP8 Dipeptidyl peptidase 8 Details 120 86 hsa-miR-221-3p AQP3 Aquaporin 3 (Gill blood group) Details 121 86 hsa-miR-221-3p SHLD2 Shieldin complex subunit 2 Details 122 85 hsa-miR-221-3p MIA3 MIA SH3 domain ER export factor 3 Details 123 85 hsa-miR-221-3p IRX5 Iroquois homeobox 5 Details 124 85 hsa-miR-221-3p CLGN Calmegin Details 125 85 hsa-miR-221-3p PGPEP1L Pyroglutamyl-peptidase I like Details 126 85 hsa-miR-221-3p KIAA1841 Kiaa1841 Details 127 85 hsa-miR-221-3p BEND4 BEN domain containing 4 Details 128 85 hsa-miR-221-3p LYPLA1 Lysophospholipase 1 Details 129 85 hsa-miR-221-3p SEMA3C Semaphorin 3C Details 130 85 hsa-miR-221-3p PAF1 PAF1 homolog, Paf1/RNA polymerase II complex component Details 131 85 hsa-miR-221-3p TRPC3 Transient receptor potential cation channel subfamily C member 3 Details 132 85 hsa-miR-221-3p RNPS1 RNA binding protein with serine rich domain 1 Details 133 84 hsa-miR-221-3p NIPAL4 NIPA like domain containing 4 Details 134 84 hsa-miR-221-3p UBE2J1 Ubiquitin conjugating enzyme E2 J1 Details 135 84 hsa-miR-221-3p ZNF385A Zinc finger protein 385A Details 136 84 hsa-miR-221-3p TSC22D3 TSC22 domain family member 3 Details 137 84 hsa-miR-221-3p ZNF181 Zinc finger protein 181 Details 138 84 hsa-miR-221-3p BEAN1 Brain expressed associated with NEDD4 1 Details 139 84 hsa-miR-221-3p KDR Kinase insert domain receptor Details 140 84 hsa-miR-221-3p GPBP1 GC-rich promoter binding protein 1 Details 141 84 hsa-miR-221-3p SNX4 Sorting nexin 4 Details 142 84 hsa-miR-221-3p L3MBTL1 L3MBTL1, histone methyl-lysine binding protein Details 143 84 hsa-miR-221-3p AIDA Axin interactor, dorsalization associated Details 144 84 hsa-miR-221-3p GDF9 Growth differentiation factor 9 Details 145 84 hsa-miR-221-3p FGF14 Fibroblast growth factor 14 Details 146 84 hsa-miR-221-3p NYAP2 Neuronal tyrosine-phosphorylated phosphoinositide- 3-kinase adaptor 2 Details 147 83 hsa-miR-221-3p MYBL1 MYB proto-oncogene like 1 Details 148 83 hsa-miR-221-3p BRWD3 Bromodomain and WD repeat domain containing 3 Details 149 83 hsa-miR-221-3p POLR3E RNA polymerase III subunit E Details 150 83 hsa-miR-221-3p IRF2 Interferon regulatory factor 2 Details 151 83 hsa-miR-221-3p ATP1B1 ATPase Na+/K+ transporting subunit beta 1 Details 152 83 hsa-miR-221-3p TUBA1A Tubulin alpha 1a Details 153 83 hsa-miR-221-3p SNRNP48 Small nuclear ribonucleoprotein U11/U12 subunit 48 Details 154 83 hsa-miR-221-3p RNF4 Ring finger protein 4 Details 155 83 hsa-miR-221-3p DNAJC6 DNAJ heat shock protein family (Hsp40) member C6 Details 156 83 hsa-miR-221-3p FXN Frataxin Details 157 82 hsa-miR-221-3p NAP1L5 Nucleosome assembly protein 1 like 5 Details 158 82 hsa-miR-221-3p BBC3 BCL2 binding component 3 Details 159 82 hsa-miR-221-3p WNK3 WNK lysine deficient protein kinase 3 Details 160 82 hsa-miR-221-3p SLC2A13 Solute carrier family 2 member 13 Details 161 82 hsa-miR-221-3p PLXNC1 Plexin C1 Details 162 82 hsa-miR-221-3p LBR Lamin B receptor Details 163 82 hsa-miR-221-3p RDX Radixin Details 164 82 hsa-miR-221-3p SYNCRIP Synaptotagmin binding cytoplasmic RNA interacting protein Details 165 81 hsa-miR-221-3p TDRP Testis development related protein Details 166 81 hsa-miR-221-3p SNAP29 Synaptosome associated protein 29 Table SII. Continued.

Target Target Target detail rank score miRNA name Gene symbol Gene description

Details 167 81 hsa-miR-221-3p ATAD2B ATPase family, AAA domain containing 2B Details 168 81 hsa-miR-221-3p AKAP5 A-kinase anchoring protein 5 Details 169 81 hsa-miR-221-3p RBP2 Retinol binding protein 2 Details 170 81 hsa-miR-221-3p INA Internexin neuronal protein alpha Details 171 81 hsa-miR-221-3p LUZP2 protein 2 Details 172 81 hsa-miR-221-3p SMARCA5 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5 Details 173 81 hsa-miR-221-3p SVIP Small VCP interacting protein Details 174 80 hsa-miR-221-3p ZFYVE16 Zinc finger FYVE-type containing 16 Details 175 80 hsa-miR-221-3p PMEPA1 Prostate transmembrane protein, androgen induced 1 Details 176 80 hsa-miR-221-3p ZFP36L2 ZFP36 ring finger protein like 2 Details 177 80 hsa-miR-221-3p ZNF624 Zinc finger protein 624 Details 178 80 hsa-miR-221-3p SEC24C SEC24 homolog C, COPII coat complex component Details 179 80 hsa-miR-221-3p RALA RAS like proto-oncogene A Details 180 80 hsa-miR-221-3p SLC6A4 Solute carrier family 6 member 4 Details 181 80 hsa-miR-221-3p RAB1A RAB1A, member RAS oncogene family Details 182 80 hsa-miR-221-3p TNRC6C Trinucleotide repeat containing 6C Details 183 80 hsa-miR-221-3p HSPA8 Heat shock protein family A (Hsp70) member 8 Details 184 80 hsa-miR-221-3p CASR Calcium sensing receptor Details 185 80 hsa-miR-221-3p PRRC2B Proline rich coiled-coil 2B Details 186 79 hsa-miR-221-3p NFYB Nuclear transcription factor Y subunit beta Details 187 79 hsa-miR-221-3p NTF3 Neurotrophin 3 Details 188 79 hsa-miR-221-3p CMTM4 CKLF like MARVEL transmembrane domain containing 4 Details 189 79 hsa-miR-221-3p PARP9 poly(ADP-ribose) polymerase family member 9 Details 190 79 hsa-miR-221-3p NANOS1 nanos C2HC-type zinc finger 1 Details 191 79 hsa-miR-221-3p ANGPTL2 Angiopoietin like 2 Details 192 79 hsa-miR-221-3p AMMECR1 Alport syndrome, mental retardation, midface hypo- plasia and Elliptocytosis chromosomal region gene 1 Details 193 79 hsa-miR-221-3p OSTM1 Osteoclastogenesis associated transmembrane protein 1 Details 194 78 hsa-miR-221-3p SOX10 SRY-box 10 Details 195 78 hsa-miR-221-3p DIRAS3 DIRAS family GTPase 3 Details 196 78 hsa-miR-221-3p ADAM17 ADAM metallopeptidase domain 17 Details 197 78 hsa-miR-221-3p LRFN2 Leucine rich repeat and fibronectin type III domain containing 2 Details 198 78 hsa-miR-221-3p ZNF275 Zinc finger protein 275 Details 199 78 hsa-miR-221-3p NFATC3 Nuclear factor of activated T cells 3 Details 200 78 hsa-miR-221-3p PTPN4 Protein tyrosine phosphatase, non-receptor type 4 Details 201 78 hsa-miR-221-3p ANKRD52 Ankyrin repeat domain 52 Details 202 78 hsa-miR-221-3p NFATC2 Nuclear factor of activated T cells 2 Details 203 77 hsa-miR-221-3p MAP4K5 Mitogen-activated protein kinase kinase kinase kinase 5 Details 204 77 hsa-miR-221-3p KMT2A Lysine methyltransferase 2A Details 205 77 hsa-miR-221-3p PLCXD3 Phosphatidylinositol specific phospholipase C X domain containing 3 Details 206 77 hsa-miR-221-3p ZFAND5 Zinc finger AN1-type containing 5 Details 207 77 hsa-miR-221-3p KCNH8 Potassium voltage-gated channel subfamily H member 8 Details 208 77 hsa-miR-221-3p NDST3 N-deacetylase and N-sulfotransferase 3 Details 209 77 hsa-miR-221-3p SLC30A6 Solute carrier family 30 member 6 Details 210 77 hsa-miR-221-3p NCKAP5 NCK associated protein 5 Details 211 77 hsa-miR-221-3p ANXA3 Annexin A3 Details 212 77 hsa-miR-221-3p EOGT EGF domain specific O-linked N-acetylglucosamine transferase Details 213 77 hsa-miR-221-3p ZBTB5 Zinc finger and BTB domain containing 5 Details 214 77 hsa-miR-221-3p BMF Bcl2 modifying factor Details 215 77 hsa-miR-221-3p CUX2 Cut like homeobox 2 Details 216 76 hsa-miR-221-3p PRDM1 PR/SET domain 1 Details 217 76 hsa-miR-221-3p FRY FRY microtubule binding protein Table SII. Continued.

Target Target Target detail rank score miRNA name Gene symbol Gene description

Details 218 76 hsa-miR-221-3p CLDN11 Claudin 11 Details 219 76 hsa-miR-221-3p PLPPR1 Phospholipid phosphatase related 1 Details 220 76 hsa-miR-221-3p PPDPFL Pancreatic progenitor cell differentiation and proliferation factor like Details 221 76 hsa-miR-221-3p CNR1 1 Details 222 76 hsa-miR-221-3p TRAF3IP2 TRAF3 interacting protein 2 Details 223 76 hsa-miR-221-3p ITGB3 Integrin subunit beta 3 Details 224 76 hsa-miR-221-3p ZNF629 Zinc finger protein 629 Details 225 76 hsa-miR-221-3p ZFP30 ZFP30 zinc finger protein Details 226 76 hsa-miR-221-3p SNCB Synuclein beta Details 227 76 hsa-miR-221-3p CPEB3 Cytoplasmic polyadenylation element binding protein 3 Details 228 76 hsa-miR-221-3p GALNT18 Polypeptide N-acetylgalactosaminyltransferase 18 Details 229 76 hsa-miR-221-3p PRICKLE2 Prickle planar cell polarity protein 2 Details 230 76 hsa-miR-221-3p MEGF9 Multiple EGF like domains 9 Details 231 75 hsa-miR-221-3p PAIP2 poly(A) binding protein interacting protein 2 Details 232 75 hsa-miR-221-3p PCDHA1 Protocadherin alpha 1 Details 233 75 hsa-miR-221-3p CBFB Core-binding factor subunit beta Details 234 75 hsa-miR-221-3p C11orf87 Chromosome 11 open reading frame 87 Details 235 75 hsa-miR-221-3p PCDHA4 Protocadherin alpha 4 Details 236 75 hsa-miR-221-3p PCDHA7 Protocadherin alpha 7 Details 237 75 hsa-miR-221-3p PCDHA3 Protocadherin alpha 3 Details 238 75 hsa-miR-221-3p PCDHA12 Protocadherin alpha 12 Details 239 75 hsa-miR-221-3p GBX2 Gastrulation brain homeobox 2 Details 240 75 hsa-miR-221-3p ZNF704 Zinc finger protein 704 Details 241 75 hsa-miR-221-3p C6orf120 Chromosome 6 open reading frame 120 Details 242 75 hsa-miR-221-3p PCDHA11 Protocadherin alpha 11 Details 243 75 hsa-miR-221-3p PCDHA2 Protocadherin alpha 2 Details 244 75 hsa-miR-221-3p DCUN1D4 Defective in cullin neddylation 1 domain containing 4 Details 245 75 hsa-miR-221-3p FBXO47 F-box protein 47 Details 246 75 hsa-miR-221-3p XIRP2 xin actin binding repeat containing 2 Details 247 75 hsa-miR-221-3p PCDHA6 Protocadherin alpha 6 Details 248 75 hsa-miR-221-3p MAGI1 Membrane associated guanylate kinase, WW and PDZ domain containing 1 Details 249 75 hsa-miR-221-3p PCDHA5 Protocadherin alpha 5 Details 250 75 hsa-miR-221-3p ZKSCAN8 Zinc finger with KRAB and SCAN domains 8 Details 251 75 hsa-miR-221-3p PCDHA10 Protocadherin alpha 10 Details 252 75 hsa-miR-221-3p PCDHAC1 Protocadherin alpha subfamily C, 1 Details 253 75 hsa-miR-221-3p PCDHA8 Protocadherin alpha 8 Details 254 75 hsa-miR-221-3p PCDHA13 Protocadherin alpha 13 Details 255 75 hsa-miR-221-3p PCDHAC2 Protocadherin alpha subfamily C, 2 Details 256 75 hsa-miR-221-3p CPNE8 Copine 8 Details 257 75 hsa-miR-221-3p PPARGC1A PPARG coactivator 1 alpha Details 258 75 hsa-miR-221-3p TMEM132C Transmembrane protein 132C Details 259 74 hsa-miR-221-3p ABHD3 Abhydrolase domain containing 3 Details 260 74 hsa-miR-221-3p MPZL1 Myelin protein zero like 1 Details 261 74 hsa-miR-221-3p VGLL4 Vestigial like family member 4 Details 262 74 hsa-miR-221-3p SRD5A3 Steroid 5 alpha-reductase 3 Details 263 74 hsa-miR-221-3p RORB RAR related B Details 264 74 hsa-miR-221-3p SCD5 Stearoyl-CoA desaturase 5 Details 265 74 hsa-miR-221-3p RALGAPA1 Ral GTPase activating protein catalytic alpha subunit 1 Details 266 73 hsa-miR-221-3p MRPS7 Mitochondrial ribosomal protein S7 Details 267 73 hsa-miR-221-3p FANCD2 FA complementation group D2 Details 268 73 hsa-miR-221-3p CLDND1 Claudin domain containing 1 Details 269 73 hsa-miR-221-3p SYCE2 Synaptonemal complex central element protein 2 Details 270 73 hsa-miR-221-3p YWHAG Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma Details 271 73 hsa-miR-221-3p TGOLN2 Trans-golgi network protein 2 Details 272 73 hsa-miR-221-3p KLC1 Kinesin light chain 1 Table SII. Continued.

Target Target Target detail rank score miRNA name Gene symbol Gene description

Details 273 73 hsa-miR-221-3p ABCA8 ATP binding cassette subfamily A member 8 Details 274 73 hsa-miR-221-3p ZNF93 Zinc finger protein 93 Details 275 73 hsa-miR-221-3p SGIP1 SH3 domain GRB2 like endophilin interacting protein 1 Details 276 73 hsa-miR-221-3p PDIK1L PDLIM1 interacting kinase 1 like Details 277 73 hsa-miR-221-3p ARAP2 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2 Details 278 73 hsa-miR-221-3p WSB2 WD repeat and SOCS box containing 2 Details 279 73 hsa-miR-221-3p SPART Spartin Details 280 73 hsa-miR-221-3p PTBP3 Polypyrimidine tract binding protein 3 Details 281 72 hsa-miR-221-3p NIPBL NIPBL, cohesin loading factor Details 282 72 hsa-miR-221-3p NOVA1 NOVA alternative splicing regulator 1 Details 283 72 hsa-miR-221-3p ZNF74 Zinc finger protein 74 Details 284 72 hsa-miR-221-3p GAB1 GRB2 associated binding protein 1 Details 285 72 hsa-miR-221-3p GTF2E1 General transcription factor IIE subunit 1 Details 286 72 hsa-miR-221-3p CAMTA1 Calmodulin binding transcription activator 1 Details 287 72 hsa-miR-221-3p ONECUT2 One cut homeobox 2 Details 288 72 hsa-miR-221-3p PLSCR4 Phospholipid scramblase 4 Details 289 72 hsa-miR-221-3p SERPINB2 Serpin family B member 2 Details 290 72 hsa-miR-221-3p EVI2A Ecotropic viral integration site 2A Details 291 72 hsa-miR-221-3p PDS5A PDS5 cohesin associated factor A Details 292 72 hsa-miR-221-3p TLNRD1 rod domain containing 1 Details 293 72 hsa-miR-221-3p DYNC1LI2 Dynein cytoplasmic 1 light intermediate chain 2 Details 294 72 hsa-miR-221-3p MAN2A1 Mannosidase alpha class 2A member 1 Details 295 72 hsa-miR-221-3p AGPS Alkylglycerone phosphate synthase Details 296 72 hsa-miR-221-3p TBXT T-box transcription factor T Details 297 72 hsa-miR-221-3p DBT Dihydrolipoamide branched chain transacylase E2 Details 298 71 hsa-miR-221-3p ENAH ENAH, actin regulator Details 299 71 hsa-miR-221-3p LRRCC1 Leucine rich repeat and coiled-coil centrosomal protein 1 Details 300 71 hsa-miR-221-3p CREBZF CREB/ATF bZIP transcription factor Details 301 71 hsa-miR-221-3p CDKN2AIP CDKN2A interacting protein Details 302 71 hsa-miR-221-3p CYLD CYLD lysine 63 deubiquitinase Details 303 71 hsa-miR-221-3p RBM24 RNA binding motif protein 24 Details 304 71 hsa-miR-221-3p KIAA0586 KIAA0586 Details 305 71 hsa-miR-221-3p ARHGEF7 Rho guanine nucleotide exchange factor 7 Details 306 71 hsa-miR-221-3p ITPR2 Inositol 1,4,5-trisphosphate receptor type 2 Details 307 71 hsa-miR-221-3p KPNA2 Karyopherin subunit alpha 2 Details 308 71 hsa-miR-221-3p ZNF25 Zinc finger protein 25 Details 309 71 hsa-miR-221-3p PDLIM2 PDZ and LIM domain 2 Details 310 70 hsa-miR-221-3p TOX Thymocyte selection associated high mobility group box Details 311 70 hsa-miR-221-3p PRKAB2 Protein kinase AMP-activated non-catalytic subunit beta 2 Details 312 70 hsa-miR-221-3p NSMCE4A NSE4 homolog A, SMC5-SMC6 complex component Details 313 70 hsa-miR-221-3p SEC24B SEC24 homolog B, COPII coat complex component Details 314 70 hsa-miR-221-3p TRPS1 Transcriptional repressor GATA binding 1 Details 315 70 hsa-miR-221-3p CLIC2 Chloride intracellular channel 2 Details 316 70 hsa-miR-221-3p NAP1L1 Nucleosome assembly protein 1 like 1 Details 317 70 hsa-miR-221-3p LRRTM2 Leucine rich repeat transmembrane neuronal 2 Details 318 70 hsa-miR-221-3p IL17RB Interleukin 17 receptor B Details 319 70 hsa-miR-221-3p SEMA6D Semaphorin 6D Details 320 70 hsa-miR-221-3p HNRNPA0 Heterogeneous nuclear ribonucleoprotein A0 Details 321 70 hsa-miR-221-3p GJC3 Gap junction protein gamma 3 Details 322 70 hsa-miR-221-3p CYREN Cell cycle regulator of NHEJ Details 323 69 hsa-miR-221-3p SOCS3 Suppressor of cytokine signaling 3 Details 324 69 hsa-miR-221-3p CYP4X1 Cytochrome P450 family 4 subfamily X member 1 Details 325 69 hsa-miR-221-3p KPNA1 Karyopherin subunit alpha 1 Details 326 69 hsa-miR-221-3p ANKRD10 Ankyrin repeat domain 10 Table SII. Continued.

Target Target Target detail rank score miRNA name Gene symbol Gene description

Details 327 69 hsa-miR-221-3p NLK Nemo like kinase Details 328 69 hsa-miR-221-3p MEX3A mex-3 RNA binding family member A Details 329 69 hsa-miR-221-3p HLTF Helicase like transcription factor Details 330 69 hsa-miR-221-3p IFIT2 Interferon induced protein with tetratricopeptide repeats 2 Details 331 69 hsa-miR-221-3p ANKS1B Ankyrin repeat and sterile alpha motif domain containing 1B Details 332 69 hsa-miR-221-3p UGT2B15 UDP glucuronosyltransferase family 2 member B15 Details 333 69 hsa-miR-221-3p CHD7 Chromodomain helicase DNA binding protein 7 Details 334 69 hsa-miR-221-3p IGF2BP2 Insulin like growth factor 2 mrna binding protein 2 Details 335 69 hsa-miR-221-3p YTHDF3 YTH N6-methyladenosine RNA binding protein 3 Details 336 68 hsa-miR-221-3p NGRN Neugrin, neurite outgrowth associated Details 337 68 hsa-miR-221-3p COBLL1 Cordon-bleu WH2 repeat protein like 1 Details 338 68 hsa-miR-221-3p CEP41 Centrosomal protein 41 Details 339 68 hsa-miR-221-3p ASB4 Ankyrin repeat and SOCS box containing 4 Details 340 68 hsa-miR-221-3p PDCD10 Programmed cell death 10 Details 341 68 hsa-miR-221-3p MASTL Microtubule associated serine/threonine kinase like Details 342 68 hsa-miR-221-3p RUNX2 Runt related transcription factor 2 Details 343 68 hsa-miR-221-3p TRABD2B TraB domain containing 2B Details 344 68 hsa-miR-221-3p PTPRZ1 Protein tyrosine phosphatase, receptor type Z1 Details 345 68 hsa-miR-221-3p FAT2 FAT atypical cadherin 2 Details 346 68 hsa-miR-221-3p FAM160B1 Family with sequence similarity 160 member B1 Details 347 68 hsa-miR-221-3p KANK4 KN motif and ankyrin repeat domains 4 Details 348 68 hsa-miR-221-3p ZNF652 Zinc finger protein 652 Details 349 67 hsa-miR-221-3p CD164 CD164 molecule Details 350 67 hsa-miR-221-3p NRG1 Neuregulin 1 Details 351 67 hsa-miR-221-3p GNB1 G protein subunit beta 1 Details 352 67 hsa-miR-221-3p CEP70 Centrosomal protein 70 Details 353 67 hsa-miR-221-3p CCSAP Centriole, cilia and spindle associated protein Details 354 67 hsa-miR-221-3p KHDRBS2 KH RNA binding domain containing, associated 2 Details 355 67 hsa-miR-221-3p ERCC4 ERCC excision repair 4, endonuclease catalytic subunit Details 356 67 hsa-miR-221-3p ACVR2B Activin A receptor type 2B Details 357 67 hsa-miR-221-3p RASSF8 Ras association domain family member 8 Details 358 66 hsa-miR-221-3p RNF20 Ring finger protein 20 Details 359 66 hsa-miR-221-3p ALDH16A1 Aldehyde dehydrogenase 16 family member A1 Details 360 66 hsa-miR-221-3p SPTBN1 Spectrin beta, non-erythrocytic 1 Details 361 66 hsa-miR-221-3p ANTXR2 ANTXR cell adhesion molecule 2 Details 362 66 hsa-miR-221-3p ANKHD1 Ankyrin repeat and KH domain containing 1 Details 363 66 hsa-miR-221-3p SLC4A4 Solute carrier family 4 member 4 Details 364 66 hsa-miR-221-3p ZNF3 Zinc finger protein 3 Details 365 66 hsa-miR-221-3p CALM1 Calmodulin 1 Details 366 66 hsa-miR-221-3p BCL2L14 BCL2 like 14 Details 367 66 hsa-miR-221-3p TYMSOS TYMS opposite strand Details 368 66 hsa-miR-221-3p CARF Calcium responsive transcription factor Details 369 66 hsa-miR-221-3p USP6NL USP6 N-terminal like Details 370 66 hsa-miR-221-3p ZC3H13 Zinc finger CCCH-type containing 13 Details 371 66 hsa-miR-221-3p DLD Dihydrolipoamide dehydrogenase Details 372 66 hsa-miR-221-3p FBXO28 F-box protein 28 Details 373 66 hsa-miR-221-3p MON2 MON2 homolog, regulator of endosome-to-Golgi trafficking Details 374 66 hsa-miR-221-3p STN1 STN1, CST complex subunit Details 375 66 hsa-miR-221-3p ETS1 ETS proto-oncogene 1, transcription factor Details 376 65 hsa-miR-221-3p CACNB4 Calcium voltage-gated channel auxiliary subunit beta 4 Details 377 65 hsa-miR-221-3p PDCD6IP Programmed cell death 6 interacting protein Details 378 65 hsa-miR-221-3p GOLGA1 Golgin A1 Details 379 65 hsa-miR-221-3p ZFHX3 Zinc finger homeobox 3 Details 380 65 hsa-miR-221-3p TMEM132B Transmembrane protein 132B Table SII. Continued.

Target Target Target detail rank score miRNA name Gene symbol Gene description

Details 381 65 hsa-miR-221-3p C22orf39 open reading frame 39 Details 382 65 hsa-miR-221-3p CCT5 Chaperonin containing TCP1 subunit 5 Details 383 65 hsa-miR-221-3p KSR1 Kinase suppressor of ras 1 Details 384 65 hsa-miR-221-3p NUFIP2 Nuclear FMR1 interacting protein 2 Details 385 65 hsa-miR-221-3p AGFG1 ArfGAP with FG repeats 1 Details 386 65 hsa-miR-221-3p TCF7L2 Transcription factor 7 like 2 Details 387 65 hsa-miR-221-3p PPP4R2 Protein phosphatase 4 regulatory subunit 2 Details 388 65 hsa-miR-221-3p STK24 Serine/threonine kinase 24 Details 389 65 hsa-miR-221-3p CDON Cell adhesion associated, oncogene regulated Details 390 65 hsa-miR-221-3p FAM222B Family with sequence similarity 222 member B Details 391 65 hsa-miR-221-3p DGKH Diacylglycerol kinase eta Details 392 64 hsa-miR-221-3p HDLBP High density lipoprotein binding protein Details 393 64 hsa-miR-221-3p SHANK2 SH3 and multiple ankyrin repeat domains 2 Details 394 64 hsa-miR-221-3p CFAP161 Cilia and flagella associated protein 161 Details 395 64 hsa-miR-221-3p CRHBP Corticotropin releasing binding protein Details 396 64 hsa-miR-221-3p CDV3 CDV3 homolog Details 397 64 hsa-miR-221-3p URI1 URI1, prefoldin like chaperone Details 398 64 hsa-miR-221-3p CD47 CD47 molecule Details 399 64 hsa-miR-221-3p SPPL3 Signal peptide peptidase like 3 Details 400 64 hsa-miR-221-3p CD4 CD4 molecule Details 401 64 hsa-miR-221-3p LRRC19 Leucine rich repeat containing 19 Details 402 64 hsa-miR-221-3p EMX2 Empty spiracles homeobox 2 Details 403 64 hsa-miR-221-3p PRDM11 PR/SET domain 11 Details 404 64 hsa-miR-221-3p PTPRR Protein tyrosine phosphatase, receptor type R Details 405 64 hsa-miR-221-3p IGDCC4 Immunoglobulin superfamily DCC subclass member 4 Details 406 64 hsa-miR-221-3p CDKN2B Cyclin dependent kinase inhibitor 2B Details 407 64 hsa-miR-221-3p TMEM25 Transmembrane protein 25 Details 408 64 hsa-miR-221-3p CAMK1D Calcium/calmodulin dependent protein kinase ID Details 409 63 hsa-miR-221-3p MGAT4A Alpha-1,3-mannosyl-glycoprotein 4-beta-N- acetylglucosaminyltransferase A Details 410 63 hsa-miR-221-3p ZFP90 ZFP90 zinc finger protein Details 411 63 hsa-miR-221-3p ERMN Ermin Details 412 63 hsa-miR-221-3p RPS3 ribosomal protein S3 Details 413 63 hsa-miR-221-3p CCP110 centriolar coiled-coil protein 110 Details 414 63 hsa-miR-221-3p NBPF3 NBPF member 3 Details 415 63 hsa-miR-221-3p CRKL CRK like proto-oncogene, adaptor protein Details 416 63 hsa-miR-221-3p REV3L REV3 like, DNA directed polymerase zeta catalytic subunit Details 417 63 hsa-miR-221-3p STYX Serine/threonine/tyrosine interacting protein Details 418 63 hsa-miR-221-3p ZNF83 Zinc finger protein 83 Details 419 63 hsa-miR-221-3p ST8SIA1 ST8 alpha-N-acetyl-neuraminide alpha-2,8- sialyltransferase 1 Details 420 63 hsa-miR-221-3p SOD2 Superoxide dismutase 2 Details 421 63 hsa-miR-221-3p SEPT14 Septin 14 Details 422 63 hsa-miR-221-3p GPD2 Glycerol-3-phosphate dehydrogenase 2 Details 423 63 hsa-miR-221-3p HIPK2 Homeodomain interacting protein kinase 2 Details 424 63 hsa-miR-221-3p HOXC10 Homeobox C10 Details 425 63 hsa-miR-221-3p STOX2 Storkhead box 2 Details 426 62 hsa-miR-221-3p PSAP Prosaposin Details 427 62 hsa-miR-221-3p DIRAS2 DIRAS family GTPase 2 Details 428 62 hsa-miR-221-3p C2CD4A C2 calcium dependent domain containing 4A Details 429 62 hsa-miR-221-3p SLC26A3 Solute carrier family 26 member 3 Details 430 62 hsa-miR-221-3p DLG2 Discs large MAGUK scaffold protein 2 Details 431 62 hsa-miR-221-3p PRDM2 PR/SET domain 2 Details 432 62 hsa-miR-221-3p C18orf54 Chromosome 18 open reading frame 54 Details 433 62 hsa-miR-221-3p CRX Cone-rod homeobox Details 434 62 hsa-miR-221-3p CAVIN3 Caveolae associated protein 3 Details 435 62 hsa-miR-221-3p STK38L Serine/threonine kinase 38 like Table SII. Continued.

Target Target Target detail rank score miRNA name Gene symbol Gene description

Details 436 62 hsa-miR-221-3p CCDC126 Coiled-coil domain containing 126 Details 437 62 hsa-miR-221-3p GLMN Glomulin, FKBP associated protein Details 438 62 hsa-miR-221-3p LGI2 Leucine rich repeat LGI family member 2 Details 439 62 hsa-miR-221-3p KBTBD11 Kelch repeat and BTB domain containing 11 Details 440 62 hsa-miR-221-3p PLEKHA2 Pleckstrin homology domain containing A2 Details 441 61 hsa-miR-221-3p SLITRK5 SLIT and NTRK like family member 5 Details 442 61 hsa-miR-221-3p THBS1 Thrombospondin 1 Details 443 61 hsa-miR-221-3p PCDHA9 Protocadherin alpha 9 Details 444 61 hsa-miR-221-3p GLS Glutaminase Details 445 61 hsa-miR-221-3p CCDC148 Coiled-coil domain containing 148 Details 446 61 hsa-miR-221-3p SLC10A7 Solute carrier family 10 member 7 Details 447 61 hsa-miR-221-3p MSL2 MSL complex subunit 2 Details 448 61 hsa-miR-221-3p MBD2 Methyl-cpg binding domain protein 2 Details 449 61 hsa-miR-221-3p PLPP3 Phospholipid phosphatase 3 Details 450 61 hsa-miR-221-3p TMEM237 Transmembrane protein 237 Details 451 61 hsa-miR-221-3p PROM2 Prominin 2 Details 452 61 hsa-miR-221-3p UBE2V1 Ubiquitin conjugating enzyme E2 V1 Details 453 61 hsa-miR-221-3p MAPK10 Mitogen-activated protein kinase 10 Details 454 61 hsa-miR-221-3p ADIPOR1 Adiponectin receptor 1 Details 455 61 hsa-miR-221-3p TMEM167A Transmembrane protein 167A Details 456 61 hsa-miR-221-3p KCNQ3 Potassium voltage-gated channel subfamily Q member 3 Details 457 60 hsa-miR-221-3p LDHAL6B Lactate dehydrogenase A like 6B Details 458 60 hsa-miR-221-3p ANKIB1 Ankyrin repeat and IBR domain containing 1 Details 459 60 hsa-miR-221-3p ECPAS Ecm29 proteasome adaptor and scaffold Details 460 60 hsa-miR-221-3p MRE11 MRE11 homolog, double strand break repair nuclease Details 461 60 hsa-miR-221-3p DCAF7 DDB1 and CUL4 associated factor 7 Details 462 60 hsa-miR-221-3p ZNF547 Zinc finger protein 547 Details 463 60 hsa-miR-221-3p GRM1 Glutamate metabotropic receptor 1 Details 464 60 hsa-miR-221-3p GPM6A Glycoprotein M6A Details 465 60 hsa-miR-221-3p BRD1 Bromodomain containing 1 Details 466 60 hsa-miR-221-3p FBN2 Fibrillin 2 Details 467 60 hsa-miR-221-3p SLC25A37 Solute carrier family 25 member 37 Details 468 60 hsa-miR-221-3p TMSB15B Thymosin beta 15B Details 469 60 hsa-miR-221-3p CSTF2T Cleavage stimulation factor subunit 2 tau variant Details 470 60 hsa-miR-221-3p RECK Reversion inducing cysteine rich protein with kazal motifs Details 471 60 hsa-miR-221-3p TBC1D22B TBC1 domain family member 22B Details 472 60 hsa-miR-221-3p SH3PXD2B SH3 and PX domains 2B Details 473 60 hsa-miR-221-3p MYO10 Myosin X Details 474 59 hsa-miR-221-3p ACADM Acyl-coa dehydrogenase medium chain Details 475 59 hsa-miR-221-3p PRUNE1 Prune exopolyphosphatase 1 Details 476 59 hsa-miR-221-3p MRAP Melanocortin 2 receptor accessory protein Details 477 59 hsa-miR-221-3p PALM2 Paralemmin 2 Details 478 59 hsa-miR-221-3p IFRD1 Interferon related developmental regulator 1 Details 479 59 hsa-miR-221-3p CDK8 Cyclin dependent kinase 8 Details 480 59 hsa-miR-221-3p ACTC1 Actin, alpha, cardiac muscle 1 Details 481 59 hsa-miR-221-3p CNPY2 Canopy FGF signaling regulator 2 Details 482 59 hsa-miR-221-3p MAGEL2 MAGE family member L2 Details 483 58 hsa-miR-221-3p TMEM165 Transmembrane protein 165 Details 484 58 hsa-miR-221-3p AADAC Arylacetamide deacetylase Details 485 58 hsa-miR-221-3p PLXDC2 Plexin domain containing 2 Details 486 58 hsa-miR-221-3p SKP1 S-phase kinase associated protein 1 Details 487 58 hsa-miR-221-3p NDFIP1 Nedd4 family interacting protein 1 Details 488 58 hsa-miR-221-3p CTTN Cortactin Details 489 58 hsa-miR-221-3p RETREG1 Reticulophagy regulator 1 Details 490 58 hsa-miR-221-3p CFHR5 Complement factor H related 5 Details 491 58 hsa-miR-221-3p HLA-F Major histocompatibility complex, class I, F Details 492 58 hsa-miR-221-3p C16orf45 Chromosome 16 open reading frame 45 Table SII. Continued.

Target Target Target detail rank score miRNA name Gene symbol Gene description

Details 493 58 hsa-miR-221-3p NDUFA1 NADH:ubiquinone oxidoreductase subunit A1 Details 494 58 hsa-miR-221-3p ENTPD7 Ectonucleoside triphosphate diphosphohydrolase 7 Details 495 58 hsa-miR-221-3p PTPRM Protein tyrosine phosphatase, receptor type M Details 496 57 hsa-miR-221-3p DEPDC4 DEP domain containing 4 Details 497 57 hsa-miR-221-3p LRRN1 Leucine rich repeat neuronal 1 Details 498 57 hsa-miR-221-3p KCNK2 Potassium two pore domain channel subfamily K member 2 Details 499 57 hsa-miR-221-3p CTCF CCCTC-binding factor Details 500 57 hsa-miR-221-3p KLF3 Kruppel like factor 3 Details 501 57 hsa-miR-221-3p HTT Huntingtin Details 502 57 hsa-miR-221-3p HEXIM1 HEXIM P-TEFb complex subunit 1 Details 503 57 hsa-miR-221-3p SATB1 SATB homeobox 1 Details 504 57 hsa-miR-221-3p OLA1 Obg like ATPase 1 Details 505 57 hsa-miR-221-3p SLC25A46 Solute carrier family 25 member 46 Details 506 57 hsa-miR-221-3p OSBPL3 Oxysterol binding protein like 3 Details 507 57 hsa-miR-221-3p IPO5 Importin 5 Details 508 57 hsa-miR-221-3p FKTN Fukutin Details 509 57 hsa-miR-221-3p SOX11 SRY-box 11 Details 510 57 hsa-miR-221-3p SLC40A1 Solute carrier family 40 member 1 Details 511 57 hsa-miR-221-3p SPATS2L Spermatogenesis associated serine rich 2 like Details 512 56 hsa-miR-221-3p MAPK8 Mitogen-activated protein kinase 8 Details 513 56 hsa-miR-221-3p GALC Galactosylceramidase Details 514 56 hsa-miR-221-3p FIGNL2 Fidgetin like 2 Details 515 56 hsa-miR-221-3p RREB1 ras responsive element binding protein 1 Details 516 56 hsa-miR-221-3p MCMDC2 Minichromosome maintenance domain containing 2 Details 517 56 hsa-miR-221-3p BBS4 Bardet-Biedl syndrome 4 Details 518 56 hsa-miR-221-3p PGGT1B Protein geranylgeranyltransferase type I subunit beta Details 519 56 hsa-miR-221-3p FOS Fos proto-oncogene, AP-1 transcription factor subunit Details 520 56 hsa-miR-221-3p TDRKH Tudor and KH domain containing Details 521 56 hsa-miR-221-3p PRKAA2 Protein kinase AMP-activated catalytic subunit alpha 2 Details 522 56 hsa-miR-221-3p SLITRK6 SLIT and NTRK like family member 6 Details 523 56 hsa-miR-221-3p RBM18 RNA binding motif protein 18 Details 524 55 hsa-miR-221-3p TAOK1 TAO kinase 1 Details 525 55 hsa-miR-221-3p CXCL11 C-X-C motif chemokine ligand 11 Details 526 55 hsa-miR-221-3p ETS2 ETS proto-oncogene 2, transcription factor Details 527 55 hsa-miR-221-3p COX15 Cytochrome c oxidase assembly homolog COX15 Details 528 55 hsa-miR-221-3p ATP2B3 ATPase plasma membrane Ca2+ transporting 3 Details 529 55 hsa-miR-221-3p ARID1A AT-rich interaction domain 1A Details 530 55 hsa-miR-221-3p RAB14 RAB14, member RAS oncogene family Details 531 55 hsa-miR-221-3p NAV3 navigator 3 Details 532 55 hsa-miR-221-3p ZNF595 Zinc finger protein 595 Details 533 55 hsa-miR-221-3p ASB7 Ankyrin repeat and SOCS box containing 7 Details 534 55 hsa-miR-221-3p ADHFE1 Alcohol dehydrogenase, iron containing 1 Details 535 55 hsa-miR-221-3p KBTBD8 Kelch repeat and BTB domain containing 8 Details 536 55 hsa-miR-221-3p PDZRN4 PDZ domain containing ring finger 4 Details 537 55 hsa-miR-221-3p STMN1 1 Details 538 55 hsa-miR-221-3p PAFAH1B2 Platelet activating factor acetylhydrolase 1b catalytic subunit 2 Details 539 55 hsa-miR-221-3p CASP3 Caspase 3 Details 540 55 hsa-miR-221-3p MAT2A Methionine adenosyltransferase 2A Details 541 55 hsa-miR-221-3p BCHE Butyrylcholinesterase Details 542 55 hsa-miR-221-3p DDX42 DEAD-box helicase 42 Details 543 54 hsa-miR-221-3p GTF2B General transcription factor IIB Details 544 54 hsa-miR-221-3p PITPNM2 Phosphatidylinositol transfer protein membrane associated 2 Details 545 54 hsa-miR-221-3p KLHL18 Kelch like family member 18 Details 546 54 hsa-miR-221-3p RNF44 Ring finger protein 44 Details 547 54 hsa-miR-221-3p SLC45A3 Solute carrier family 45 member 3 Table SII. Continued.

Target Target Target detail rank score miRNA name Gene symbol Gene description

Details 548 54 hsa-miR-221-3p SLC6A9 Solute carrier family 6 member 9 Details 549 54 hsa-miR-221-3p LIFR LIF receptor alpha Details 550 54 hsa-miR-221-3p ARHGAP42 Rho GTPase activating protein 42 Details 551 54 hsa-miR-221-3p VEZF1 Vascular endothelial zinc finger 1 Details 552 54 hsa-miR-221-3p RAB3GAP2 RAB3 GTPase activating non-catalytic protein subunit 2 Details 553 54 hsa-miR-221-3p MTMR6 Myotubularin related protein 6 Details 554 53 hsa-miR-221-3p MED1 Mediator complex subunit 1 Details 555 53 hsa-miR-221-3p COL6A5 Collagen type VI alpha 5 chain Details 556 53 hsa-miR-221-3p USP49 Ubiquitin specific peptidase 49 Details 557 53 hsa-miR-221-3p RGS8 Regulator of G protein signaling 8 Details 558 53 hsa-miR-221-3p CD8A CD8a molecule Details 559 53 hsa-miR-221-3p MPRIP Myosin phosphatase Rho interacting protein Details 560 53 hsa-miR-221-3p KIAA1549L KIAA1549 like Details 561 53 hsa-miR-221-3p C12orf77 Chromosome 12 open reading frame 77 Details 562 53 hsa-miR-221-3p PRAMEF13 PRAME family member 13 Details 563 53 hsa-miR-221-3p NIPA1 NIPA magnesium transporter 1 Details 564 53 hsa-miR-221-3p RANBP2 RAN binding protein 2 Details 565 53 hsa-miR-221-3p PRAMEF14 PRAME family member 14 Details 566 53 hsa-miR-221-3p KCNH1 Potassium voltage-gated channel subfamily H member 1 Details 567 53 hsa-miR-221-3p SLC16A6 Solute carrier family 16 member 6 Details 568 53 hsa-miR-221-3p PCDH11X Protocadherin 11 X-linked Details 569 53 hsa-miR-221-3p CHORDC1 Cysteine and histidine rich domain containing 1 Details 570 53 hsa-miR-221-3p PCDH11Y Protocadherin 11 Y-linked Details 571 52 hsa-miR-221-3p BCL11B BCL11B, BAF complex component Details 572 52 hsa-miR-221-3p C4orf33 Chromosome 4 open reading frame 33 Details 573 52 hsa-miR-221-3p PRSS37 Serine protease 37 Details 574 52 hsa-miR-221-3p KCNA1 Potassium voltage-gated channel subfamily A member 1 Details 575 52 hsa-miR-221-3p LRP10 LDL receptor related protein 10 Details 576 52 hsa-miR-221-3p DYRK1A Dual specificity tyrosine phosphorylation regulated kinase 1A Details 577 52 hsa-miR-221-3p SLAIN2 SLAIN motif family member 2 Details 578 52 hsa-miR-221-3p DDX58 DExD/H-box helicase 58 Details 579 52 hsa-miR-221-3p TAF9B TATA-box binding protein associated factor 9b Details 580 52 hsa-miR-221-3p CYP1B1 cytochrome P450 family 1 subfamily B member 1 Details 581 52 hsa-miR-221-3p UBN2 Ubinuclein 2 Details 582 52 hsa-miR-221-3p GPATCH2L G-patch domain containing 2 like Details 583 52 hsa-miR-221-3p SNCA synuclein alpha Details 584 52 hsa-miR-221-3p WDR77 WD repeat domain 77 Details 585 52 hsa-miR-221-3p IL1RAP Interleukin 1 receptor accessory protein Details 586 51 hsa-miR-221-3p CHFR Checkpoint with forkhead and ring finger domains Details 587 51 hsa-miR-221-3p C16orf82 Chromosome 16 open reading frame 82 Details 588 51 hsa-miR-221-3p ZBTB20 Zinc finger and BTB domain containing 20 Details 589 51 hsa-miR-221-3p ESYT1 Extended synaptotagmin 1 Details 590 51 hsa-miR-221-3p KRT81 81 Details 591 51 hsa-miR-221-3p DICER1 Dicer 1, ribonuclease III Details 592 51 hsa-miR-221-3p MDM2 MDM2 proto-oncogene Details 593 51 hsa-miR-221-3p ZBTB41 Zinc finger and BTB domain containing 41 Details 594 51 hsa-miR-221-3p NCAM1 Neural cell adhesion molecule 1 Details 595 51 hsa-miR-221-3p MAP4K4 Mitogen-activated protein kinase kinase kinase kinase 4 Details 596 51 hsa-miR-221-3p MYOD1 Myogenic differentiation 1 Details 597 51 hsa-miR-221-3p GNB3 G protein subunit beta 3 Details 598 51 hsa-miR-221-3p MMD2 Monocyte to macrophage differentiation associated 2 Details 599 51 hsa-miR-221-3p SLC25A21 Solute carrier family 25 member 21 Details 600 50 hsa-miR-221-3p ITPRID1 ITPR interacting domain containing 1 Details 601 50 hsa-miR-221-3p CAVIN4 Caveolae associated protein 4 Details 602 50 hsa-miR-221-3p AGO4 Argonaute RISC catalytic component 4 Table SII. Continued.

Target Target Target detail rank score miRNA name Gene symbol Gene description

Details 603 50 hsa-miR-221-3p AJAP1 Adherens junctions associated protein 1 Details 604 50 hsa-miR-221-3p ITIH5 Inter-alpha-trypsin inhibitor heavy chain family member 5 Details 605 50 hsa-miR-221-3p CNKSR3 CNKSR family member 3 Details 606 50 hsa-miR-221-3p CT45A5 Cancer/testis antigen family 45 member A5 Details 607 50 hsa-miR-221-3p PKDCC Protein kinase domain containing, cytoplasmic Details 608 50 hsa-miR-221-3p STAT2 Signal transducer and activator of transcription 2 Details 609 50 hsa-miR-221-3p A4GNT Alpha-1,4-N-acetylglucosaminyltransferase Details 610 50 hsa-miR-221-3p CT45A10 Cancer/testis antigen family 45 member A10 Details 611 50 hsa-miR-221-3p GCNT1 Glucosaminyl (N-acetyl) transferase 1 Details 612 50 hsa-miR-221-3p ERI2 ERI1 exoribonuclease family member 2 Details 613 50 hsa-miR-221-3p APAF1 Apoptotic peptidase activating factor 1 Details 614 50 hsa-miR-221-3p CLDN12 Claudin 12 Details 615 50 hsa-miR-221-3p SAR1A Secretion associated Ras related gtpase 1A