September/October 2016 volume 12, issue 2 Advancing Biomedical Science, Education, and Health Care

Children, families to benefit doubly from Child Study Center gifts A focus on enhancing parents’ Turning innovative ideas into well-being to better prepare practical therapies and better them to care for their children access to needed care andrew redleaf andrew & When parents seek mental health The Yale Child Study Center (CSC)

services for their children, they may has a distinguished history of applying jerry domian

be ill equipped to choose the most courtesy lynne scholarship and research to the clinical A gift from the Viola W. Bernard Foundation to the medical school’s Child Study Center will further Ber- A gift from Andrew Redleaf and Lynne Singer Redleaf lets effective approach. Even after they needs of children in New Haven and nard’s vision of turning theory into effective mental the Child Study Center focus new attention on the well- health delivery. With the Center’s director Linda C. have obtained professional help for being of parents as they care for special needs children. Connecticut. Famously, 25 years ago, Mayes (center) are the Foundation’s treasurer Cary a child, they may not realize how the center launched a program that Koplin (left) and its vice president and founder Joan valuable it can be to receive care graduate of Yale College, wanted to encouraged New Haven child mental Wofford, a niece of Bernard. for themselves, both for their own directly contribute to a program dedi- health professionals and police officers well-being and to help them better cated to these challenges. to intervene on behalf of children and it caught the attention of a pioneering address the child’s needs. Lynne recalls that as she raised a families exposed to severe trauma. psychiatrist, Viola W. Bernard, M.D., Spurred by personal experi- son who had emotional and behavioral The initiative, called the Child De- who tirelessly advocated for practi- ences, Lynne Singer Redleaf and her challenges, finding support services velopment-Community Policing Pro- cal solutions for child well-being and husband, Andrew Redleaf, a 1978 near her home in // Parents (page 5) gram (CD-CP), was so successful that health. After her // CD-CP (page 5)

Addiction pioneer recognized with professorship Four new leaders to helm medical school Leader of Connecticut-based departments vaccine maker endows chair Four departments at Yale School of for chief of internal medicine Medicine have new leaders. They are Lucian V. Del Priore, m.d., ph.d., As executive chair and head of global of ophthalmology and visual sci- business development at Meriden, ence; Gary V. Desir, m.d., of internal Conn.-based Protein Sciences, Dan medicine; Linda C. Mayes, m.d., of Adams develops and manufactures the Child Study Center; and David G. vaccines. The School of Medicine’s Schatz, ph.d., of immunobiology. Patrick G. O’Connor, m.d., m.p.h., Lucian V. Del Priore became chair chief of general internal medicine, of the Department of Ophthalmol- works to improve treatment for ogy and Visual Science and chief of addiction in primary care settings, harold shapiro Ophthalmology at Yale New Haven Dean Robert J. Alpern (left) hosted a gathering honoring Patrick G. O’Connor (right) as inaugural recipient of where help may be most accessible. an endowed professorship named for Dan Adams and his daughter Amanda Adams (second and third from Hospital (ynhh) on July 1. He was The two men share a commitment right). O’Connor researches innovative ways to treat addiction in primary care and internal medicine settings. recruited from the Medical University to the mission statement of Protein of South Carolina, where he had led Sciences, which reads in part: senior vice president and assistant opioid addiction. That rests solidly the ophthalmology department as the “To save lives and improve health by general counsel at Citicorp, and a 1997 on Patrick’s research.” Pierre G. Jenkins Chair and directed effectively responding to the chang- graduate of Yale College. O’Connor conducted the first the Storm Eye Institute. Del Priore, ing world.” O’Connor’s research focuses on randomized clinical trial of bu- the Robert R. Young Professor of This past spring, in recognition the interfaces among general internal prenorphine for the treatment of Ophthalmology and Visual Science, of that common vision, O’Connor medicine, primary care, and addic- opioid dependence in primary care, specializes in retinal diseases, glau- was named the first Dan Adams and tion. “His internationally renowned published in the American Journal of coma, and vitreoretinal surgery. He Amanda Adams Professor of General work has already made a tremendous Medicine in 1997. He has conducted helped facilitate the first clinical trial Medicine. Dan Adams, a former mem- difference in how drug and alcohol numerous National Institutes of using stem cells to treat patients with ber of the School of Medicine’s Dean’s addictions are treated,” says Robert Health (nih) clinical trials, includ- Stargardt macular dystrophy and Council, created the professorship with J. Alpern, M.D., dean and Ensign ing a randomized trial of naltrexone age-related macular degeneration. a substantial endowment. Professor of Medicine. “Office-based for the treatment of alcohol depen- In 1982, he received his m.d. The endowment honors Amanda treatment with buprenorphine is now dence using a primary care-based with distinction in research from Adams, who is Dan Adams’ daughter, the most common form of therapy for management // Professorship page 8) the University of // Chairs (page 4)

Non-Profit Org. INSIDE THIS ISSUE 1 Church St., Suite 300, New Haven, CT 06510-3330 U. S. Postage www.medicineatyale.org 2 Lifelines PAID Alison P. Galvani uses powerful mathemati- New Haven, CT cal models to both predict and change the Permit No. 526 trajectory of deadly infectious disease. 3 Embracing big-data research The new Yale Center for Research Comput- ing has the technology and expertise to help investigators execute their research. 5 NIH renews prestigious funding Benefits of grants from the National Center for Advancing Translational Sciences include funding for junior investigators. FOLLOW & SHARE: twitter.com/YaleMed facebook.com/YaleMed instagram.com/YaleMed lifelines Pathologist named director of tumor profiling lab

Alison P. Galvani, the youngest Janina A. Long- person ever appointed to an endowed professorship at the tine, m.d., has medical school, has combined been appointed technology with the power of mathematics to predict patterns vice chair of of deadly infectious disease. pathology and Galvani’s work has changed the trajectory of disease treatment laboratory medi- and prevention. cine and director of molecular and Janina Longtine genomic diag- nostics at Yale School of Medicine and director of the Tumor Profiling Laboratory at Smilow Cancer Hospital. Throughout her 30-year career, Longtine has developed deep expertise in molecular pathol- Alison P. Galvani ogy. In her new role, she plans to harold shapiro integrate patient management and individualized cancer care with tumor profiling services. Longtine The ecology of disease will work with the departments of pathology and laboratory medi- From the flu to Ebola, Robert May. Following a postdoctoral the basis for effective ways to stem cine, in addition to the Center for fellowship at the University of Cali- the epidemic. Their predictions of the Genome Analysis at West Campus, predicting and then fornia, Berkeley, she came to Yale as a impact of combined interventions— to foster integration across mo- stifling pathogens’ spread junior faculty member. By that time her published in the journal Science— lecular diagnostic services within pioneering work in behavioral epidemi- forecast trajectories of the epidemic the medical school. Alison P. Galvani, ph.d., the Burnett and ology—how human behavior leads to in Liberia with remarkable accuracy. Longtine came to Yale this past Stender Families Professor of Epidemiol- and affects disease transmission—was Galvani’s team also developed a spring from Icahn School of Medi- ogy, has devoted her research career to well underway. “I’m fascinated by the smartphone app to track the location cine at Mount Sinai in New York tracking diseases, and to transforming power of mathematics to contribute of symptomatic patients. Previously, where she was tenured professor data into predictive maps and practical in very practical ways to the benefit of with only pencil and paper to do that and vice chair of molecular pathol- policy recommendations. So distin- society,” she says. job, the arrival of ambulances had been ogy and genetics. Before joining guished is her body of work that in 2015, Galvani’s team at Yale has con- delayed by as much as several days. at age 38, Galvani became the youngest- ducted international investigations With resources in Liberia severely Mount Sinai in 2011, Longtine held ever appointee to an endowed profes- into the transmission of hiv, influenza, limited, cidma contributed more than multiple appointments at Brigham sorship at the School of Medicine. Ebola, and Zika, among other patho- 30 computers and phones to the Ebola and Women’s Hospital and Dana- When Galvani was just 5 years gens. “We are most interested in proj- response team so that the mobile Farber Cancer Institute and was old, growing up in San Francisco, her ects that have the potential to improve application could function. Patients associate professor of pathology at mother—a clinical psychologist—died. policy and save lives,” she says. Her received hospital care far more rapidly, Harvard Medical School. According to Galvani, her grief instilled work on influenza and rotavirus has led improving recovery rates and curtailing She studied molecular biology in her an abiding passion for helping to concrete policy changes and made further transmission. at Wellesley College and earned the downtrodden and orphaned. vaccination programs in Israel and the Galvani has received numerous her m.d. in 1981 from the Uni- When she was in high school, a United Kingdom more cost effective. honors including the Blavatnik Award versity of Massachusetts Medical copy of Richard Dawkins’ book The Galvani established the Center for for Young Scientists from the New York School. Longtine completed her Blind Watchmaker sparked her inter- Infectious Disease Modeling and Academy of Sciences, the Bellman Prize, est in evolutionary biology. Galvani Analysis (cidma) within the School of and a Guggenheim Fellowship. residency in anatomic pathol- took it upon herself to write a letter to Public Health in 2014, shortly before Throughout her career, as she has ogy and a clinical fellowship in Dawkins challenging some of his prem- the Ebola epidemic hit western Africa. managed students and postdocs, and hematopathology at Brigham ises and outlining some of her own When it did, she offered her team’s raised three children in a home that and Women’s Hospital. In addi- ideas about evolutionary processes. help in understanding the disease’s also includes a dog and a full chicken tion, she completed two research Dawkins praised Galvani in his reply dynamics to Liberia’s health ministry, coop, Galvani has continued to apply fellowships in molecular biology and encouraged her to apply to the which welcomed the aid. Galvani and the lessons of evolutionary biology that at Children’s Hospital Boston and University of Oxford for an undergradu- her colleagues worked tirelessly to she first learned from Dawkins. “The Brigham and Women’s Hospital. ate degree in biology. generate models to capture the level of same principles of ecology and species Galvani not only took his advice, virus in patients, the patients’ survival conservation apply, but in reverse,” she but remained at Oxford to pursue a outcomes, and the social behavior of says. “In disease systems, we want to doctorate under theoretical biologist affected families, all of which formed drive the parasite species extinct.” Managing Editor Robert Forman Contributors Sonya Collins, Sarah Faulkner, Charles Gershman, Rod Granger, Kathleen Raven, Amy Rich, Colleen Shaddox, and Karen Zusi Pediatrician recognized for clinical excellence in neonatology Design Jennifer Stockwell Medicine@Yale is published four times each year by: Yale School of Medicine, Office of Communications Matthew J. Bizzarro, m.d., associate After attending medical school 1 Church Street, Suite 300, New Haven, CT 06510-3330 professor of pediatrics and medical at the University of Medicine and Telephone: (203) 785-5824 Fax: (203) 785-4327 director of Yale New Haven Chil- Dentistry of New Jersey, Bizzarro Email [email protected] dren’s Hospital’s Neonatal Intensive completed his residency at New York Website medicineatyale.org Copyright ©2016 by Yale University. All rights reserved. Care Unit (nicu), is the 2016 recipi- University Medical Center and joined If you have a change of address or do not wish to receive ent of the David J. Leffell Prize for Yale as a fellow in 2002. future issues of Medicine@Yale, please write to us at the Clinical Excellence. The prize is given Bizzarro said at the ceremony above address or via email at [email protected]. Postal permit held by Yale University,

to individuals who demonstrate the that he felt drawn to pediatrics and harold shapiro 155 Whitney Avenue, New Haven, CT 06520 highest level of clinical expertise, critical care as a medical student but Neonatologist Matthew J. Bizzarro (rear, second commitment to teaching, and com- discovered his true passion in caring from left), seen with members of his family, has been honored for the excellence of his clinical work. Robert J. Alpern, m.d. passion for patients. for sick newborns at Yale. “Watching Dean and Ensign Professor of Medicine At a ceremony at the Sterling Hall babies you’ve spent months taking of Dermatology and professor of Charles Turner Associate Vice President for Development and of Medicine, Bizzarro said, “It was care of go home with their families is surgery, and his wife, Cindy, in honor Director of Medical Development (203) 436-8560 difficult to think I’ve been singled out an overwhelming feeling,” he said. of Leffell’s 30th Yale College reunion. Mary Hu given the quality of the [neonatology] The Leffell Prize was created in It includes a monetary award and a Associate Dean for Communications and Chief Communications Officer group. I would challenge anyone to 2008 with a gift from David J. Leffell, framed citation to be displayed in the find a better group of clinicians.” m.d., the David P. Smith Professor Sterling Hall of Medicine. Printed on recycled paper ♻

2 www.medicineatyale.org advances Health & Science News New center boosts big-data research Molecule plays main From training to hardware to hands-on resources. Jay D. Humphrey, ph.d., the John C. Malone role in cell crosstalk Professor of Biomedical Engineering, is interested in help with data, the Yale Center for Research understanding how blood flows through the complex Computing gives investigators an added edge vasculatures of patients with abdominal aneurysms. Using patient-specific images of aneurysms, Paolo Di Achille, a As big data becomes integral to many academic disciplines, doctoral candidate in Humphrey’s lab, creates computer research universities have found a need to upgrade both models that can predict where a blood clot will form the technologies they use and the skill sets of research pro- within an aneurysm. This work could help clinicians fessionals who must organize and analyze the data. It was decide whether or not to intervene when a patient has an

hyung j. chun, m.d. this need that motivated the creation of the Yale Center for aneurysm and there is risk that a blood clot will form. Blood vessels form through a complex Research Computing (ycrc) in 2015, says Kiran Keshav, Humphrey’s team uses the supercomputers available series of interactions among cells e.m.s., the center’s executive director, and senior director through the ycrc, such as the clusters “Omega” and called “crosstalk.” Researchers led of research technologies at Yale University. “Grace.” They also use clusters in such places as Texas and by Hyung J. Chun, m.d., associate The ycrc provides Yale researchers a resource for com- San Diego through a National Science Foundation-funded professor of medicine, have identified plex computing support. Located on Yale’s Science Hill, consortium called Extreme Science and Engineering Dis- a crucial player in the process: a tiny the center provides the cyber-infrastructure researchers covery Environment. Di Achille first learned how to use rna molecule known as miR-139-5p. need to do their work and guidance on how to maintain supercomputers through a ycrc-run workshop. “Having The researchers studied mice that the infrastructure. It also provides education and train- [the supercomputers] here and having some practice on lacked either the gene apelin (apln) ing, such as programming. Before the center’s creation, them allows me to quickly adapt the workflow to clusters or its receptor (aplnr), and found the Keshav says, support for computational research was somewhere else,” he says. retinal vasculature of these mice to be decentralized. “One of the first things I wanted to do was Humphrey’s research on blood clots and abdominal severely underdeveloped. They also to collocate all the staff. All the people who were effectively aneurysms is “computationally expensive”—meaning it found in the blood vessels of these doing research computing support for faculty needed to requires large amounts of computing power. He notes the mice that the expression of a related be together,” he says. “Now it’s the start of a community. gene that directs a distinct set of cel- We’re building a one-stop shop for technology-related sup- At right, Kiran Keshav lular signaling, known as cxcr4, was (center) talks with port for research.” The ycrc has supported researchers in Andrew Sherman (left) aberrantly increased. The crosstalk numerous ways. Alan Anticevic, ph.d., assistant professor and Robert Bjornson. between these molecules was medi- Below, members of the of psychiatry and psychology, uses computational methods Yale Center for Research ated by miR-139-5p, which controls combined with imaging techniques to better understand Computing and Yale’s expression of cxcr4 and is essential Information Technology the mechanisms underlying such psychiatric illnesses as Services Research for normal vascular development. schizophrenia and addiction. Where today Technologies staff. (2) harold shapiro The finding demonstrates a novel clinicians diagnose these illnesses using mechanism by which interdepen- qualitative measures such as behavior, An- dence between signaling pathways is ticevic predicts that one day they will be established in the developing blood able to diagnose with far more precision vessels. The findings, published by measuring associated brain mecha- April 12 in Nature Communications, nisms. He has used the high-performance have implications for conditions computing resources at the ycrc to inves- including heart disease, cancer, and tigate these dysfunctional brain circuits. blinding diseases of the retina. The ycrc has also helped to acquire new super-computing technology for Why flu is deadly Yale researchers. Robert Bjornson, ph.d., senior research scientist in Yale’s Depart- among the elderly ment of Computer Science and a member There’s good reason behind doctors’ of the ycrc staff, recently assisted the recommendation that older adults Yale Center for Genome Analysis in secur- receive the flu vaccine annually. Each ing a grant from the National Institutes of year, 90 percent of deaths worldwide Health to replace an old high-performance related to influenza A virus (iav) computing cluster. The newly purchased strike men and women aged 65 and cluster went online this spring, bringing older. The trouble, according to a an additional two petabytes of storage and widely accepted theory, is that iav a great deal more computing power for ge- replicates quickly and overwhelms nome analysis. The new cluster was named Ruddle, after value of having a center on campus dedicated to research older adults’ immune systems, thus the late Francis H. (“Frank”) Ruddle, a School of Medicine computing support. “It’s more than just maintaining hard- making them more susceptible to scientist who famously pioneered genetic engineering. ware or having the right software available,” he says. “It’s catching pneumonia and the like. These clusters are used by people such as Mark B. really about understanding what’s needed to do state-of- A study published in April in the Gerstein, ph.d., the Albert L. Williams Professor of the-art computation and enabling the people who use the journal Science suggests that the Biomedical Informatics, who is working to identify the facility to be able to do it in an efficient way.” body’s inflammatory immune re- function of particular regions of the human genome. As Medical students should also be prepared to deal with sponse, not the virus, leads to death. sequencing the human genome becomes increasingly the era of big data, according to the co-chair of the center’s Akiko Iwasaki, ph.d., Waldemar Von accessible, researchers are using the technology to better faculty advisory committee, Harlan M. Krumholz, m.d., s.m., Zedtwitz Professor of Immunobiol- understand disease. Structural changes along the genome the Harold H. Hines Jr. Professor of Medicine and professor ogy and an investigator of the Howard are prevalent in genomic diseases such as cancer. of investigative medicine and of public health. “With medi- Hughes Medical Institute, and col- “People in genomics were using big data before it was cine, this [data] is the next big thing. We think discoveries are leagues found that immune cells from cool,” says Gerstein, who also is professor of molecular going to be accelerated by our better use of digital data.” older adults secrete significantly less biophysics and biochemistry and of computer science. As Krumholz says the old approach of memorizing risk interferon, a key antiviral protein. a genomic researcher, Gerstein needs to handle very large factors to categorize patients may be on its way out. “I think The authors then created mice datasets and organize the data in a way that will provide we’re going to move toward taking all the information about with immune systems that mimicked meaningful insights in medicine. He says that research you and be able to see how it affects your risk and response this weakened response. “Although computing support should be separate from a general to disease and treatment—being able to personalize our ap- the virus was not sufficient to kill information technology department, and is glad to work proach in ways doctors could never memorize.” mice, the immune response, driven by with the ycrc. The center isn’t just for the people who want to be more neutrophils [white blood cells], led to “Configuring the hardware, knowing what to get, do- computer savvy in research, Krumholz says. “This center excessive inflammation and lung dam- ing everything correctly in relation to federal grants and should be an organizing force. I think we will have been age,” says lead author Padmini S. Pillai, contracts—that takes quite a bit of effort on the part of successful if this kind of training becomes an integral part a doctoral student in Iwasaki’s lab. everyone. The ycrc are the point people to help get those to every different part of the university.” The study could point to new things working,” says Gerstein. Keshav and his colleagues hope to expand the ycrc’s anti-inflammation flu treatments Genomics may be an obvious beneficiary of the re- training opportunities and continue hosting events. For that target and calm this overactive sources at the ycrc, but research in fields such as biomedi- now, the center continues to provide support to the grow- immune response. cal engineering also depends on the center’s computation ing need for technological support in research.

Medicine@Yale September/October 2016 3 out & about

March 19 A Donate Life America charity 2 1 2 May 19 event styled after the popular “Dancing with The Class the Stars” television show. 1. Margaret of 2016 J. “Peggy” Bia, m.d., professor of medicine in celebrated nephrology, danced with her husband, Frank J. 75 percent

Bia, m.d., m.p.h., professor emeritus of medicine harold shapiro participa- in infectious diseases, while en- April 19 A lecture sponsored by the tion in harold shapiro gaging in friendly competition 1 Association of Yale Alumni in Medicine. its Graduating Class Gift campaign ben- against colleagues. 2. Gary 1. Fred Aslan, m.d. ’02, m.b.a., founder and efitting financial aid. Leadership included V. Desir, m.d., chair of internal chief executive officer of Adavium Medi- class co-presidents (left to right) Mona medicine and professor of cal, described various ways that m.d. or Guo, m.d. ’16; Richard Kayne, m.d. ’76, medicine and his wife, Deborah ph.d. degrees can contribute to careers in the Association of Yale Alumni in Medi- Desir, m.d., a rheumatologist in business. 2. Medical student Jonathan cine president; and Joel Winer, m.d. ’16,

the New Haven community. robert lisak (2) Park listened from the audience. m.h.s. ’16.

May 23 At Commencement, Anthony 1 1 2 S. Fauci, m.d., director of the National In- stitute of Allergy and Infectious Diseases at the National Institutes of Health, ad- dressed the graduating class. 1. Michael Chang showed his pleasure for the camera. 2. From left, Vikram Jairam,

Raj Chovatiya, Chang-Yeon Kim, Mat- curtis john thew Mikhail, and Benjamin Lerner. 2 3 3. From left, Veronica Shi, Xiaoyue Mona Guo, Vinay Rathi and Connie Cheng June 3–4 Alumni and friends participated in wait. 4. Bethlehem Mekonnen and Reunion Weekend events. 1. Medical student Lise Nadine Tchouta walk together from Robert Rock led an art observation education- main campus to the medical school’s al session at Yale University Art Gallery. graduation ceremony. 2. Attendees Heather Yun, m.d. ’01 and her son,

3 4 Theo Yun; listened to Tiffany Moadel, m.d., director of medical student simulation at the 4 Yale Center for Medical Simulation (in white coat), as Kathleen Figaro, m.d. ’96, looked on. 3. At a panel, Joel Winer, m.d. ’16, m.h.s. ’16, and Rebecca Vitale, m.d. ’15, m.h.s. ’16, an- swered questions with Robert M. Rohrbaugh, m.d. ’82, professor of psychiatry and director of the Office of International Medical Student

john curtis john robert lisak (3) Education. 4. Members of the Class of 1981.

// Chairs (from page 1) Rochester School within the department, having served of Medicine and Dentistry and then as vice-chair. Schatz is Waldemar earned a ph.d. in physics at Cornell Von Zedtwitz Professor of Immuno- University. Del Priore completed an biology and a professor of molecular internal medicine internship at the biophysics and biochemistry, and Greater Baltimore Medical Center has been a Howard Hughes Medical in 1984, followed by a residency in Institute Investigator since 1991. ophthalmology and fellowships in He has made fundamental contri- vitreoretinal surgery and glaucoma Lucian Del Priore Gary Desir David Schatz Linda Mayes butions to the field’s understanding at the Wilmer Eye Institute at Johns of the mechanisms that assemble and Hopkins University School of Medi- As a physician-scientist, Desir Mayes, who is trained as a pediatri- diversify the antigen receptor genes cine. He succeeds interim chair Ron has contributed significantly to cian, neonatologist, and adult and that encode antibodies and T cell Adelman, m.d., professor of ophthal- understanding mechanisms that child psychoanalyst, earned her m.d. receptors. Schatz may be best known mology and visual science, and direc- regulate body weight and insulin at Vanderbilt University School of for the discovery of rag1 and rag2, tor of the Retina and Macula Center. sensitivity. He has delineated the Medicine in Nashville. She completed subsequent biochemical insights into Gary V. Desir has been named chair mechanism by which renalase, a her pediatric internship, pediatric rag function and evolutionary ori- of the Department of Internal Medi- growth factor he discovered, pro- residency, and neonatology fellow- gins, and important insights into the cine after serving as interim chair since tects cells from ischemic and toxic ship at Vanderbilt before joining Yale regulation of somatic hypermutation. 2013. He is the Paul B. Beeson Professor injury, and shown that dysregulated in 1985. He received b.s. and m.s. degrees of Medicine in the section of nephrol- renalase signaling can promote the Mayes’s research focuses on the in molecular biophysics and biochem- ogy, and also is ynhh’s chief of internal survival of cancer cells. stress-response and regulatory mech- istry from Yale. As a Rhodes Scholar, medicine. He serves as board chair for A champion of diversity and social anisms in young children at both bio- Schatz studied at Oxford University Yale Medicine, the medical school’s re- justice, Desir is a co-founder of the logical and psychosocial risk and the for two years, earning a b.a. degree cently renamed faculty clinical practice, Minority Organization for Retention long-term impact of chronic stress in philosophy and politics in 1982. and holds a secondary appointment at and Expansion, a faculty group fo- and adversity on children’s health He subsequently entered the gradu- Yale’s School of Forestry and Environ- cused on increasing faculty diversity and development. She integrates ate program in the biology depart- mental Studies. through mentoring programs and perspectives from psychophysiology, ment at the Massachusetts Institute Desir immigrated from Haiti to developing social networks. neurobiology, child development, and of Technology, performing his thesis the United States after high school. After a career at Yale spanning behavioral neuroscience. research with Nobel Laureate David He earned his m.d. from Yale School nearly three decades, Linda C. Mayes Mayes served as interim chair af- Baltimore, ph.d., at the Whitehead of Medicine and completed his has been appointed director of the ter Fred Volkmar, m.d., the Irving B. Institute for Biomedical Research and training in internal medicine and Child Study Center and chief of child Harris Professor in the Child Study receiving his ph.d. degree in 1990. nephrology at ynhh before joining psychiatry at Yale New Haven Chil- Center and professor of psychology, In assuming his new role as chair, the medical school’s faculty, where he dren’s Hospital. Mayes is the Arnold stepped down as chair. Schatz succeeds Richard A. Flavell, has served as chief of nephrology and Gesell Professor of Child Psychia- The incoming Department of Im- ph.d., Sterling Professor of Immuno- chief of medicine at the VA Connecti- try, Pediatrics, and Psychology, and munobiology chair, David G. Schatz, biology, who became founding chair cut Healthcare System. serves as Special Advisor to the Dean. is already an established leader of the department in 1988.

4 www.medicineatyale.org advances A ‘far-reaching’ federal grant is renewed Health & Science News Investigating genes’ Beneficiaries of the five-year award is a critical part of our mission that will have far-reaching impact going forward.” on/off switches include junior faculty poised to conduct Scholars and trainees interested in pursuing transla- clinical and translational investigations tional research have been drawn from a range of disciplines across Yale’s Schools of Medicine, Nursing, and Public The School of Medicine has received $53.6 million from Health, and from the Department of Biomedical Engineer- the National Center for Advancing Translational Sciences ing at the School of Engineering and Applied Science. Under to renew its five-year Clinical and Translational Science the renewal, Yale has expanded the number of slots in its Award (ctsa) to accelerate research discoveries that can tl-1 Multidisciplinary Pre-Doctoral Training Program in have a positive impact on health.

istockphoto.com This is the second renewal for Yale, Humans have up to 25,000 protein- which was among the first 12 institutions coding genes. dna methylation, which nationally to receive ctsa funding when occurs when methyl groups are added the National Institutes of Health (nih) to dna, plays a crucial role in which started the program in 2006. The award genes get turned on or off. Methyl supports the Yale Center for Clinical groups alter a chromosome, but not Investigation (ycci), established in 2005 as the dna sequence itself. For decades, part of the medical school’s strategic plan scientists thought a methyl group to develop an infrastructure to support could bond only to cytosine—one of research and educate the next generation dna’s four bases. of investigators. Andrew Xiao, ph.d., associate “We’ve made incredible strides under professor of genetics, and his team the ctsa in establishing a robust infra- reported in Nature that methylation structure and resources for investigators,” occurs on another dna base: adenine. says Robert J. Alpern, m.d., dean and Xiao investigated how this methyl Ensign Professor of Medicine. “I am de- bond interacts with a specific trans- lighted that ctsa support will allow us to

poson, which is an ancient virus that continue to expand our research enterprise robert lisak invaded our genome long ago and to support the acceleration of treatments Robert S. Sherwin (left) and Dean Robert J. Alpern say a five-year renewal of the federally funded Clinical and Translational Science Award promises to spur new research by the most junior members of Yale now serves to control gene expres- from the bench to the bedside.” School of Medicine’s faculty. sion, especially on X chromosomes. ctsa hubs are expected to streamline “We know transposons are help- the research process to get studies up and running more Translational Research from 10 to 20, the maximum number ful because they can freely jump to quickly; collaborate with one another; and, with com- allowed. The kl-2 Mentored Clinical Scholars Program is different parts of the chromosome, munity providers, patients, and industry, to use tools and also expanding from seven partially funded scholars to nine. thus allowing our dna to modify to resources to their best advantage; to promote team science; During the next five years, ycci will also pursue new different environmental factors,” and develop effective ways of improving the recruitment and partnerships to develop and market therapeutics that ad- Xiao said. Since these transposons retention of clinical trial participants. dress unmet clinical needs. In addition, with a goal of mak- are also found in cancer cells, perhaps Educating tomorrow’s clinician scientists is also a top ing funded research especially robust, ycci will encourage this type of dna methylation could be priority under the ctsa. “I am very proud of the success investigators to tap into Yale New Haven Health’s database a target for cancer, Xiao said. of our educational programs to train medical students, of more than 4 million electronic health records, which physicians, postdoctoral fellows and junior faculty,” says reflect a large and diverse patient population. Support How a gene thwarts Robert S. Sherwin, m.d., principal investigator of the ctsa, from CTSA continues to help transform Yale into a “learn- director of ycci and the C.N.H. Long Professor of Medicine ing health system” that generates innovative strategies for cancer defenses (endocrinology). “Continuing these efforts under the ctsa disease prevention, diagnostics, and therapeutics. A Yale-led study describes how a known cancer gene, egfr, silences // Parents (from page 1) Minnesota was psychology, genetics, neurobiology, services that are specifically for par- genes that typically suppress tumors. endlessly frustrating. “I have health and neuroimaging. ents, focusing on how their needs are The finding, published in Cell Reports, insurance, I have connections, I have During a visit to Yale, the Redleafs met, with the understanding that that may lead to the development of more intellectual resources,” she says. “And met with csc researchers and learned in turn facilitates meeting the child’s effective, individualized treatment yet I had a lot of trouble finding help about Minding the Baby, a collabora- needs,” Mayes says. for patients with lung cancer and for my son.” Lynne wanted other tion between Yale and the city of New Through PFDP, parents are able to other cancer types. families to have an easier path. Haven that brings together home receive job skills training and educa- Mutations in the egfr gene are So, this year the Redleafs gave visiting teams to promote physical and tional opportunities, and to learn skills linked to multiple cancer types, in- $10 million to the medical school’s mental health, and improved attach- that can help them build healthier so- cluding cancers of the lung, brain, and Child Study Center (csc) to support ment outcomes in babies, mothers, cial interactions. By coordinating these breast. Yet scientists did not know the launch of its Parent and Fam- and their families. efforts, the center allows parents to precisely how egfr represses genes ily Development Program (pfdp). The pfdp focuses on the adult obtain comprehensive care in one place. that prevent cancers. The Yale team Established in March, the pfdp is transition to parenthood and provides Mayes and Megan V. Smith, ph.d., conducted multiple experiments a collaborative hub of integrated services that address parents’ needs, m.p.h., assistant professor of psychia- and found that egfr silences tumor clinical services for parents across says Linda C. Mayes, m.d., the Arnold try, are co-directors of the pfdp. Both suppressor genes in lung cancer and disciplines and departments, Gesell Professor of Child Psychiatry, will be involved with academic research glioblastoma, a type of brain cancer. including child and adult psychia- Pediatrics, and Psychology and direc- intended to inform the program’s “egfr can target multiple unrelated try, pediatrics, perinatal medicine, tor of the csc. “We bring together methods and demonstrate its efficacy. tumor suppressor genes in different cancer types using a common mecha- // CD-CP (from page 1) death in 1998, partnership with a professional treasurer Cary A. Koplin, a graduate nism,” said senior author Narendra the Viola W. Bernard Foundation gave from another discipline; and to of the Yale College Class of 1966. Wajapeyee, assistant professor of pa- $100,000 to help the Child Study Cen- fund an annual lecture series ad- According to the Foundation, its thology and a member of Yale Cancer ter continue the CD-CP. dressing social justice and health namesake psychiatrist had little patience Center. egfr silences these genes by This past spring, the Foun- care equity topics. The endowment for ideas that could not be applied in negatively regulating a protein called dation made an endowed gift of leaves CSC better positioned both real world situations. “Viola really took tet1, which is required to suppress $2.35 million to establish the Viola to create and research new delivery a multidisciplinary, multi-faceted ap- tumors, he noted. W. Bernard Fund for Innovation models and to improve access to proach to complex problems,” says Joan The finding informs the future in Mental Health Care. The fund mental health care for children and Wofford, M.A.T. ’59, Bernard’s niece and direction of research and treatment serves three purposes: to provide their families. the Foundation’s vice president. of patients who don’t respond or a fellowship in social justice and “Our foundation is very confi- “She did not want to just write a develop resistance to drugs that health care equity for mental health dent that we have found the perfect check to feed children,” Koplin adds, inhibit egfr, he said. “It will also help professional trainees; to award a vehicle to perpetuate the mission of drawing a distinction between help determine how effective cancer prize for innovation in child mental the Bernard Foundation and of what with temporary benefits and more therapies will be against different health care delivery to a mental Viola wanted and gave 60 years of her lasting solutions. “She wanted to create egfr mutations.” health professional working in life toward,” says board member and replicable programs.”

Medicine@Yale September/October 2016 5 Novel pet Methods, 4.8 years, $3,662,999; nih, Role of tam Receptors in Modulation of Tropho- pet-Derived ‘Dopamine Movies’ of Early-Stage blast Function and Vascular Remodeling in Obstet- Addiction to Cigarette Smoking: A Pilot Study, ric aps, 3 years, $197,799 • Adedotun Adebamiro, Grants and contracts awarded 1.9 years, $383,783 • Walter Moss, nih, Under- American Society of Nephrology, Ben J. Lipps standing Epstein Barr Virus Oncogenicity through Research Fellowship Program, 2 years, $100,000 Non-Coding rna Structure, 2 years, $180,000 Nadia Ameen, University of Miami (nih), Microvil- to Yale School of Medicine Walther Mothes, nih, Single Molecule Imaging lus Inclusion Disease: Polarized Traffic and Signal- of hiv-1 Entry, 4 years, $1,550,477 • Karla ing, a Lead to Therapy, 11 months, $153,333 • Emily July 2015–November 2015 Neugebauer, nih, Cross-Regulation Between Ansell, Peter F. McManus Charitable Trust, Rela- Transcription and Pre-mRNA Splicing, 4.9 years, tionship Processes in Couples Coping with ptsd $1,621,781 • Stefania Nicoli, nih, Integrating that Increase Risk for Hazardous Drinking, 1 year, Federal miR-107 into Signaling Pathways that Coordinate $50,000 • Alan Anticevic, Brain & Behavior Clara Abraham, nih, Mechanisms Regulating Inhibitor MK-3475 in Patients with Non-Small Cell Neurogenesis and Brain Vascular Permeability, Research Foundation (formerly narsad), Dissect- Innate Immune Responses, 1 year, $416,250 Lung Cancer and Brain Metastases, 2 years, 5 years, $2,092,500 • James Noonan, nih, Identify- ing Psychosis via Multimodal Neuroimaging, Phar- Frederick Altice, nih, Prison Interventions and hiv $399,599 • Daniel Goldstein, nih, Academic Lead- ing Enhancers with Human-Specific Developmen- macology and Computation, 2 years, $100,000 Prevention Collaboration, 5 years, $3,318,630 ership in the Biology of Aging and Cardiovascular tal Functions, 4 years, $2,602,928 • Kevin Amy Arnsten, BlackThorn Therapeutics, Effects Meenakshisundaram Ananthanarayanan, Jittima Diseases, 4.7 years, $650,535 • Jose Gomez Vil- O’Connor, nih, Mechanisms of Autoantibody Pro- of Kappa Receptor Antagonist on Prefrontal Func- Weerachayaphorn, Michael Nathanson, nih, Reg- lalobos, nih, Functional Role of hsa-miR-504 in duction in Myasthenia Gravis, 3 months, $416,250; tions Related to Decision Making, 2.5 years, ulation of Cholestasis by Inositol Trisphosphate Airway Inflammation and Remodeling in Asthma, nih, Mechanisms of Autoantibody Production In $695,214 • Marc Auerbach, Children’s Hospital Receptors, 1 year, $245,760 • Karen Anderson, 5 years, $694,575 • Elena Gracheva, nih, The Role Myasthenia Gravis, 5 years, $1,779,271 • Chirag Los Angeles, Using Leaderboards to Improve cpr DoD, Exploring apobec 3B as a Novel Target for of trpm8 and Nav1.8 Channels in Cold Tolerance Parikh, nih, Leveraging Clinical Trials of Diabetic Simulation Practice Among Healthcare Profes- Squamous Cell Lung Cancer, 1 year, $166,500 of Hibernators, 4.8 years, $1,820,029 • Eduardo Kidney Disease to Advance Biomarkers, 4.9 years, sionals, 2 years, $3,278 • Jeffrey Bender, State of Deborah Ayeni, nih, Modulation of the Immune Groisman, nih, Co-Opting Ancestral Regulatory $2,259,831 • Godfrey Pearlson, nih, 3/5 Bipolar Conn. Dept. of Public Health, Macrophage Integ- System as a Strategy to Treat egfr Mutant Lung Systems to Control Bacterial Virulence, 11 months, Schizophrenia Network for Intermediate Pheno- rin-Modulated rna Stability in Neovessel Forma- Adenocarcinoma, 2 years, $55,536 • Byoung-Il Bae, $368,148 • Marc Hammarlund, nih, New Mecha- types 2 (bsnip-2), 4.8 years, $3,507,892 • Godfrey tion, 2 years, $343,834 • Anton Bennett, Broad nih, Molecular Control of Brain Size, 1.4 years, nisms in Axon Regeneration, 5 years, $1,821,095 Pearlson, Michael Stevens, nih, Neuroscience of Institute, Investigating ptprf Function in Schizo- $417,787 • Nigel Bamford, nih, Dopamine-Induced Roy Herbst, Susan Mayne, nih, Yale spore in Lung Marijuana Impaired Driving, 4.8 years, $2,868,635 phrenia, 1 year, $83,250 • Xin Bian, Human Frontier Striatal Synaptic Plasticity, 4.5 years, $1,762,940 Cancer (ysilc): The Biology and Personalized Kevin Pelphrey, nih, Training Program in Child- Science Program Organization, ER-PM Tethering Susan Baserga, nih, Predoctoral Program in Cellu- Treatment of Lung Cancer, 4.9 years, $11,384,992 hood Neuropsychiatric Disorders, 5 years, Protein Extended Synaptotagmin 1 Plays an Impor- lar and Molecular Biology, 5 years, $6,842,040; Joy Hirsch, nih, Mechanisms of Interpersonal $2,012,516 • Christopher Pittenger, nih, Charac- tant Role in Cell Migration, 3 years, $160,980 nih, Key Factors in Human Ribosome Biogenesis, Social Communication: Dual-Brain fnirs Investiga- terization of Sera from Patients with pandas, Marcus Bosenberg, Kim Blenman, Lucia Jila- 3.7 years, $1,578,269 • Joerg Bewersdorf, nih, An tion, 4.9 years, $2,063,155 • Jonathon Howard, nih, 1 year, $58,800 • Mohini Ranganathan, nih, veanu, Susan Kaech, Melanoma Research Founda- Integrated Imaging System for High-Throughput Cell Biological Limitations Constrain Dendritic Gender Related Differences in the Acute Effects tion, Mechanisms Controlling Melanoma Dor- Nanoscopy of the 4D Nucleome, 2.8 years, Branching Morphology and Neuronal Function, of Delta-9-Tetrahydrocannabinol in Healthy mancy and Metastatic Progression, 2 years, $990,000 • Linda Bockenstedt, nih, Borrelia 4.9 years, $4,162,490 • Evelyn Hsieh, nih, Risk for Humans, 2 years, $359,975 • Leslie Rickey, nih, $400,000 • James Boyer, Intercept Pharmaceuti- Miyamotoi Infection in Mice and Humans, 1 year, Bone Loss Among Individuals with hiv in a Prevention of Lower Urinary Tract Symptoms in cals, The International Primary Sclerosing Cholan- $670,392 • Jonathan Bogan, nih, Vesicle Translo- Resource-Limited Environment, 4.9 years, $691,741 Women: Yale Bladder Health Clinical Center, gitis Study Group Meeting, 9 months, $34,000 cation and the Metabolic Syndrome, 4 years, Shuta Ishibe, nih, Role of Calpain in Podocyte 4.9 years, $2,482,819 • Jesse Rinehart, nih, Reveal- Michael Bracken, Brian Leaderer, Janneane Gent, $1,498,500 • Angelique Bordey, nih, Cortical Injury, 5 years, $1,873,125 • Alla Ivanova, nih, Role ing Substrates and Phosphoproteome Level Func- Theodore Holford, State of Conn. Dept. of Public Tuber and Epilepsy, 2 years, $459,375 • Clemente of the Mitochondrial Protein Fus1 in Age-Related tion of Human ste20 Kinases, 4.9 years, $1,666,790 Health, Environmental Tobacco Smoke and Britto-Leon, nih, splunc1 and Neutrophilic Inflam- Hearing Loss, 2 years, $457,875 • Yasuko Iwakiri, John Rose, nih, Testing a Novel Approach Toward Asthma Exacerbations in Children of Low Income mation in Cystic Fibrosis, 4.7 years, $694,575 nih, Alcohol Metabolism in Liver Sinusoidal Endo- a Multivalent Chikungunya/Dengue Vaccine, Families: A Feasibility Study, 2 years, $210,972 Martina Brueckner, nih, Genetics and Genomics thelial Cells, 2 years, $437,063 • Daniel Jane-Wit, 2 years, $457,875 • Michael Rowe, Chyrell Bellamy, Elizabeth Bradley, World Health Organization, of Congenital Heart Disease and Associated nih, Mechanisms of Non-Canonical NF-kB Activa- Larry Davidson, Marc Rosen, William Bromage, Liberia Health Workforce Program: Health Man- Neurodevelopmental Abnormalities, 5 years, tion in Transplant Arteriosclerosis, 1 year, $131,895 nih, Financial and Mental Health: Exploratory agement, 7 months, $96,241; Bill and Melinda $2,358,063; nih, Intraciliary Calcium Directs Raymond Johnson, nih, Role of Plac8 in Natural Research and Model Development, 2 years, Gates Foundation, Primary Health Care Unit Cardiac Left-Right Asymmetry, 4 years, $2,341,984 and Vaccine-Generated Immunity Against $749,250 • Albert Sinusas, nih, Training in Multi- Transformation Initiative (pti), 3.2 years, Richard Bucala, nih, Aging and Innate Immune Chlamydia Infections, 3.9 years, $1,469,424; nih, modality Molecular and Translational Cardiovas- $7,501,334; imd Marketing Consulting, Hospital Mechanisms in Pulmonary Infection, 4 years, Role of CD8IL-13 T Cells in Chlamydia Infection- cular Imaging, 5 years, $1,525,521 • Stefan Somlo, Leadership Certificate Program, 2 years, $200,000 $1,665,000 • Matthew Burg, nih, ptsd, Sleep, and Associated Immunopathology, 1.7 years, $413,977 DoD, The Therapeutic Effect of the Antitumor Douglas Brash, l’oreal, Controlling Chemiexcita- Risk for Incident Hypertension, 3.7 years, Anne Marie Jukic, nih, An Investigation of Drug 11beta and Related Molecules on Polycystic tion in the Skin: Exploration of Dark cpd Produc- $3,205,335 • Cecilia Canessa, nih, Probing asic1 Vitamin D in Human Fertility and Early Pregnancy, Kidney Disease, 3 years, $1,248,750 • Hugh Taylor, tion in Skin, 2 years, $426,323 • William Cafferty, Function In Vivo Using Novel Genetic Tools, 3 years, $727,794 • Naftali Kaminski, Patty Lee, nih, The Yale wrhr Career Development Center, State of Conn. Dept. of Public Health, Novel Cell 1.9 years, $457,875 • Michael Caplan, nih, Path- nih, Training in Translational Lung Biology and 5 years, $1,701,000 • Jacob Tebes, nih, Research Autonomous Modulators of Intrinsic cns Axon ways and Partners in Renal Epithelial Cell Polarity, Pathobiology, 5 years, $3,198,385 • Naftali Kamin- Training Program in Substance Abuse Prevention, Growth Enhance Functional Recovery after Stroke, 4.4 years, $1,498,500 • Sandy Chang, nih, Telo- ski, nih, Genomic Analysis of Tissue and Cellular 5 years, $1,730,976 • Jeffrey Testani, nih, Diagnos- 2 years, $246,108; Craig H. Neilsen Foundation, mere Dysfunction and Genome Instability in Famil- Heterogeneity in ipf, 3.8 years, $3,069,296 • Insoo ing and Targeting Mechanisms of Diuretic Resis- Polyphosphate-5-Phosphatases Modulate Intrin- ial Melanoma, 2 years, $400,110; nih, Telomere Kang, nih, Aging and IL-7-Mediated CD8+ T Cell tance in Heart Failure, 4.8 years, $3,778,556 sic cns Axon Growth, 2 years, $300,000; Connect- Dysfunction Induced Breast Cancer Pathogenesis, Survival, 1 year, $416,250 • Samuel Katz, nih, Syn- Susumu Tomita, nih, Regulation of Glutamate icut Innovations, Polyphosphate-5-Phosphatases 5 years, $1,914,446 • William Chang, nih, Investi- ergizing Pro-Apoptotic and Car-T Cell Immuno- Receptors by Calcium-Dependent Protein Kinases, Enhance Functional Regeneration after Spinal gating Endothelial Cell and Glomerular Anastomo- therapy for Mantle Cell Lymphoma, 2 years, 2.8 years, $1,248,750 • Christian Tschudi, nih, rna Cord Injury, 2 years, $200,000 • John Cahill, Vinod ses to Advance Kidney Tissue Engineering, $398,352 • Barbara Kazmierczak, nih, Medical Metabolism in Trypanosomes, 5 years, $3,912,820 Srihari, Patrick and Catherine Weldon Donaghue 3.9 years, $766,104 • Keith Choate, nih, Genetics Scientist Training Program, 5 years, $11,438,674 Vasilis Vasiliou, nih, Glutathione Monoesters to Medical Research Foundation, ‘stepping Out’: and Pathobiology of Disorders of Keratinization, Trace Kershaw, nih, Research Education Institute Counteract Ocular Chemical Injury, 2 years, Supporting the Dissemination of step Care Using 4.9 years, $2,398,083 • Jaehyuk Choi, nih, The Role for Diverse Scholars (reids), 4.8 years, $1,323,281 $692,027 • Daniel Vatner, nih, In Vivo Regulation an Outcomes-Based Care Management Tool and of zeb1 Mutations in Cutaneous T Cell Lymphoma, Albert Ko, nih, Naturally Acquired and Vaccine- of Lipid Flux in the Etiology of nafld and Insulin Online Community, 1.5 years, $55,000 • Kathleen 2 months, $15,669 • Lawrence Cohen, nih, Optical Mediated Immunity to Leptospirosis, 5 years, Resistance, 4.8 years, $722,410 • Narendra Carroll, McLean Hospital (nih/dhhs), Clinical Studies of Neuron Activity and Organization, $4,003,326 • Jonathan Koff, nih, Novel Role of Wajapeyee, nih, Metabolic Drivers of Lung Cancer Trials Network: New England Consortium Node, 5 years, $1,727,806 • Peter Cresswell, nih, The Role egfr in Virus-Induced Asthma Exacerbations, Initiation, Progression and Therapy Response, 9 months, $384,117 • Richard Carson, ucb Bio- of gilt in the Generation of Reactive Oxygen 4.9 years, $2,081,250 • Camille Konopnicki, nih, 2 years, $398,352; nih, A Novel Drugable Genetic Pharma sprl (formerly ucb Pharma S.A.), Novel Species, 2 years, $457,875 • Alecia Dager, nih, Connecting Interpersonal Variation in Gut Micro- Vulnerability Pathway in Melanoma, 5 years, pet Ligand Selection Study in nhps, 4 months, Neurochemical and Functional Correlates of bial Communities to Warfarin Efficacy, 2 years, $1,914,446; nih, Anoikis Effectors as Drivers of $181,652; ucb BioPharma sprl (formerly ucb Memory in Emerging Adult Marijuana Users, $106,600 • Priti Kumar, nih, Exploring Antibody- Metastatic Melanoma, 2 years, $399,982 • Lisa Pharma S.A.), Novel pet Ligand Selection Study in 4 years, $658,940 • Enrique De La Cruz, nih, Actin Fc Effector Function in Humanized Mouse Models Walke, tbn, dhhs, Geriatrics Workforce Enhance- nhps, 1.2 years, $95,738 • Marcelo Cassini, pkd Filament Elasticity and Actin-Binding Protein of hiv Latency, 2 years, $464,478 • Daeyeol Lee, ment Program, 3 years, $2,480,940 • Emily Wang, Foundation for Research in Polycystic Kidney Function, 3.9 years, $1,705,106 • Elise DeVito, nih, nih, Neural Basis of Temporal Decision Making, Department of Justice, Measuring Successful Disease, Can Mcp1 Knock-out and Blockage of comt Inhibition as a Novel Treatment for Nicotine 5 years, $2,085,711 • Patty Lee, nih, tlr4-Mediated Reentry: Linkage of Corrections and Community Macrophage Receptor CCr2 Alter the Outcome of Addiction in Women, 2 years, $359,975 • Sabrina Mechanisms of Lung Aging, 1 year, $402,618 Healthcare Data, 1.5 years, $258,113 • Daniel Wein- Polycystic Kidney Disease (pkd)?, 2 years, Diano, nih, Mitochondrial Dynamics in vmh Rafael Lefkowitz, dhhs, Risk Factors for Injury and berger, nih, Forecasting Pneumococcal Serotype $100,000 • Sandy Chang, State of Conn. Dept. of Neurons Control Glucose Metabolism, 3.9 years, Illness in Seafarers, 3 years, $324,000 • Mark Frequencies to Develop Adult-Specific Vaccines, Public Health, Role of Dysfunctional Telomeres in $1,498,500; nih, Central Prolyl Carboxypeptidase Lemmon, 1 tbn, nih, Understanding egf Receptor 1 year, $426,511 • Sandra Wolin, nih, Recruitment Breast Cancer Pathogenesis, 2 years, $300,010 (prcp) in the Regulation of Metabolism, 5 years, Activation by Growth Factors and Oncogenic of Host Noncoding rnas by hiv-1, 2 years, $467,109 Lieping Chen, Pfizer, U.S. Pharmaceuticals Group, $1,883,062 • Marcelo Dietrich, nih, The Intracellu- Mutations, 5 years, $2,560,782 • Ifat Levy, nih, Qin Yan, DoD, BC141326: Epigenetic Mechanisms Discovery and Development of New Immune lar Dynamics of agrp Neurons Under Different Medical Decision Making Under Uncertainty in of Breast Cancer Metastasis, 5 years, $4,162,496 Modulation Agents—Development of New Mouse Metabolic Conditions, 5 years, $1,873,125 • Deepak Older Adults—Behavior and fmri, 1.6 years, Xiaoyong Yang, nih, O-GlcNAc Signaling in Models for Human Immune-Onocology, 3 years, D’Souza, nih, Intravenous Alcohol and thc Effects $457,875 • Janghoo Lim, nih, Cellular and Molecu- Central Control of Energy Balance, 3.9 years, $2,373,222; Next Cure, Discovery of Novel on Simulated Driving and Related Cognition, lar Studies of sbma Neuromuscular Disease, $1,761,556 • Yang Yang, DoD, The Intraovarian Immuno-Oncology Targets and Development of 2 years, $343,613 • Marie Egan, nih, Targeted Cor- 5 years, $1,821,095 • Elan Louis, nih, Clinical Patho- Tumorigenesis of Extra Ovarian Originated Therapeutic Agents, 5 years, $12,388,461 • Sidi rection of the Human cftr Gene, 3.8 years, logical Study of Cognitive Impairment in Essential Ovarian Cancer, 5 years, $1,190,500 • Kimberly Chen, Damon Runyon Cancer Research Founda- $2,219,404 • Anne Eichmann, nih, Targeting Endo- Tremor, 3.9 years, $2,561,629; nih, In Vivo Quantifi- Yonkers, nih, Progesterone Augmentation for tion, Investigation of Dicer as a Novel Therapeutic thelial Migration to Prevent Neovascularization, cation of Cerebellar gaba and naa in Essential Smoking Cessation in Women, 2 years, $398,352; Route Toward the Inhibition of Tumorigenesis and 3.8 years, $1,665,000; nih, Novel Approaches to Tremor, 3 years, $1,887,554; nih, Environmental dhhs, Prenatal Substance Use Screening: Valida- Neoplastic Growth, 2 years, $100,000 • Shih- Manipulate Sprouting Angiogenesis, 5 years, Epidemiology of Essential Tremor, 7 months, tion and Comparison of Promising Measures, Chuan Chou, Emergency Medicine Foundation, $1,873,125 • Irina Esterlis, nih, pet-fmri Study of $532,480 • Xingguang Luo, nih, Post-gwas Tran- 2 years, $1,199,816 • Hitten Zaveri, nsf, cps: A Secret-Shopper Evaluation of Primary Care Glutamate and Frontal Function in Bi- and Uni- scriptome-Wide Lncrna Expression Profiling in Synergy: Collaborative Research: Fault Tolerant Access Following ED Discharge-Evaluating the Polar Depression, 4.8 years, $3,573,873 • Lauren Alcohol Dependence, 2 years, $343,613 • Shrikant Brain Implantable Cyber-Physical System, 3 years, Impact of the Affordable Care Act, 1 year, $9,250 Ferrante, nih, Critical Illness, Disability, and Vul- Mane, nih, High Performance Computing Instru- $487,712 • David Zenisek, nih, Investigating the Oscar Colegio, Doris Duke Charitable Foundation, nerability in Older Persons, 1.8 years, $249,750 mentation for the Yale Center for Genome Analy- Role of Ribeye in Retinal Ribbon Function, 5 years, Defining Intercellular Metabolic Networks in David Fiellin, nih, Working with hiv Clinics to sis, 1 year, $889,820 • Stephanie Marshall, nih, The $1,665,000 • Yongli Zhang, nih, Single-Molecule Human Cutaneous Squamous Cell Carcinoma, Adopt Addiction Treatments Using Implementa- Role of Hepatic fmo3 in Ethanol Induced Liver Manipulation of snares, 3.8 years, $1,434,716 3 years, $486,000 • Susan Compton, aclam Foun- tion Facilitation (What If?), 4.7 years, $2,866,224 Injury, 2 years, $110,236 • Sherry McKee, samhsa, Sheng Zhang, nih, Thalamic Cortical Dysfunction dation, Biology and Impact of Murine Astrovirus, Jorge Galán, nih, Mechanisms of Type III Protein Integrated System of Care for Addicted Offenders and Predictors of Relapse in Cocaine Dependence, 1 year, $14,750 • Gianfilippo Coppola, Connecticut Secretion, 5 years, $2,854,225 • Alison Galvani, Re-Entering Their Communities, 3 years, $1,195,353 5 years, $834,352 • Z. Jimmy Zhou, nih, Functional Innovations, Brain-on-Chip, 2 years, $199,979 nsf, Collaborative Research: Signaling Prosociality: James McPartland, nih, Multimodel Assessment Dissection of New Retinal Circuits, 3 years, Guoliang Cui, Cancer Research Institute, The Harnessing Impure Motives to Help Others, of Social Process Systems across Neurodevelop- $1,255,000 Influence of Nutrient Availability in the Tumor 3 years, $57,626 • Jean-Francois Geschwind, nih, mental Disorders, 3 years, $650,980 • Gil Mor, nih, Microenvironment on CD8+ T Cell Survival and See, Reach, Treat Tumor-Optimized Transarterial Targeting the Vascularity for Delivery of Inhibitors Non-federal Function, 2 years, $106,000 • John Davis, Univer- Chemoembolization Drug Delivery, 11 months, of Metastasis in Ovarian Cancer, 5 years, Clara Abraham, Crohn’s & Colitis Foundation of sity of California, Berkeley, Fogarty International $549,874 • Michael Girardi, nih, Local Immunoreg- $2,555,885; nih, Effect of Polymicrobial Infection America (ccfa), Mechanisms Modulating Pattern Center (nih/dhhs), International Research Train- ulation of Cutaneous Carcinogenesis, 5 years, on Trophoblast-Macrophage Interactions, 1 year, Recognition-Induced Signaling in Human Myeloid- ing on TB and Other Pulmonary Complications of $1,987,679 • Sarah Goldberg, DoD, Evaluation of $401,793 • Evan Morris, nih, Imaging Sex Differ- Derived Cells, 3 years, $347,488 • Vikki Abrahams, hiv, 2.5 years, $15,782; Regents University of Cali- Biomarkers Predictive of Benefit from the PD-1 ences in Smoking-Induced Dopamine Release Via American Heart Association (Founders Affiliate), fornia, San Francisco (nih/dhhs),

6 www.medicineatyale.org Inflammation, Aging, Microbes, and Obstructive Transgenic Rats and Establishing Neurophysiol- Robert Makuch, Merck & Company, The cfda Forebrain Precursors, 4.8 years, $264,577; Simons Lung Disease (I AM OLD) Study, 10 months, ogy-Based Translations Biomarkers, 1 year, Training for October 2015, 3 months, $77,825 Foundation, Extending asd Risk Locus Discovery $14,739 • Maria Teresa Dell’Anno, Marco Onorati, $175,492 • Ilan Harpaz-Rotem, Brain & Behavior Carolyn Mazure, Community Foundation for to the Non-Coding Genome through the Integra- Connecticut Innovations, Human Neuroepithelial Research Foundation (formerly narsad), Combin- Greater New Haven, General Operating Support tion of Multidimensional Biological Data, 1.5 years, Stem Cells in Spinal Cord Injury, 2 years, $200,000 ing Neurobiology and New Learning: Ketamine and for Heart and Cancer Research—Research, 3 years, $60,000 • Liang Shan, American Foundation for Kamil Detyniecki, Acorda Therapeutics, Demo- Prolonged Exposure: A Potential Rapid Treatment $150,000 • Sherry McKee, Lumme (nih), Leverag- aids Research (amfAR), Identification, Reactiva- graphics, Clinical Characteristics, Frequency, and for ptsd, 2 years, $100,000 • Jose Herazo-Maya, ing Mobile Biosensors for Just-In-Time Interven- tion and Elimination of Latent hiv-1 in Humanized Associated Outcomes of Seizure Clusters Among Pulmonary Fibrosis Foundation, Serum microrna tion, 1.8 years, $649,282 • Ruslan Medzhitov, Mice, 2 years, $150,000 • Frederick Shic, Pamela Outpatients with Epilepsy at Two Tertiary Care Expression Profiles as Biomarkers in Idiopathic Pul- AbbVie, Identification and Targeting of Tfh-Induc- Ventola, Simons Foundation, Tracking Interven- Centers, 4 years, $48,872 • Marcelo Dietrich, monary Fibrosis, 2 years, $50,000; Robert Wood ing Dendritic Cells, 4 years, $1,665,000 • Alan tion Effects with Eye Tracking, 2 years, $499,862 Whitehall Foundation, Dissecting Interoceptive Johnson Foundation, Peripheral Blood Biomarkers Morrison, Actelion Pharmaceuticals U.S., Devel- Satinder Singh, Brain & Behavior Research Foun- Circuits Critical for Cognitive Outputs, 3 years, in ipf–Role of Aberrant Immunity, 4 years, opment of Microrna-based Therapeutic Strate- dation (formerly narsad), Elucidating the Biophys- $225,000; Charles H. Hood Foundation, Hypotha- $420,000 • Kevan Herold, Tiziana Life Sciences, gies for Pulmonary Artery Hypertension, 1 year, ical Role of pick1/dat Interactions in Attention lamic Circuits Underlying Brain Development Preclinical Studies of NI-0401 in Humanized Mice $100,000 • Angus Nairn, Rockefeller University, Deficit Hyperactivity Disorder and Comorbid During Childhood, 2 years, $150,000 • Edward at Yale University (K. Herold), 1 year, $133,652; Assaying Translational Dynamics in Specific Neu- Neuropsychiatric Diseases, 2 years, $100,000 Doherty, Mallinckrodt Pharmaceuticals, Mallinck- Merck Sharp & Dohme, Do Humanized Mice Reca- ronal Subtypes, 11 months, $101,582 • Deepak Michael Skonieczny, Anglia Ruskin University, rodt Pharmaceuticals Research Fellowship, 1 year, pitulate the Clinical Experience of a Synergistic Narayan, Baxter Healthcare Corporation, Lower Training and Development aru HEEoE, 1 year, $80,000 • George Dragoi, Whitehall Foundation, Hepatotoxic Response after Administration of Extremity Surgery Cadaver Lab, 1 year, $5,000 $150,000 • Patrick Skosnik, Forum Pharmaceuti- Neuronal Ensembles Underlying Internal Repre- Immune Checkpoint Blockade (icb) Inhibitors?, Laura Niklason, Karen Hirschi, Connecticut Inno- cals (Formerly En Vivo Pharmaceuticals), Novel sentations, 3 years, $225,000 • Robert Dubrow, 1 year, $100,000 • Ellen Hoffman, Simons Founda- vations, Engineered Arteries and iPS-Derived Electrophysiological Biomarkers Sensitive to Overlook International Foundation, The Yale tion, High-Throughput Drug Discovery in Zebra- Endothelium, 3 years, $748,926 • Elaine O’Keefe, Treatment with the Alpha 7 nAChR Partial Agonist School of Public Health Response to Climate fish Models of asd Risk Genes, 2 years, $250,000 imd Marketing Consulting Co., Disaster Prepared- evp-6124 in Schizophrenia, 1 year, $26,090 Change: Educating and Training the Next Genera- Theodore Holford, University of Michigan (nih/ ness Program: Education and Training for Chinese Lindsey Stavola, American Physiological Society, tion of Public Health Leaders, 3.9 years, $1,096,679 dhhs), Comparative Modeling of Lung Cancer Pre- Government Officials and Leaders, 1 year, $7,400 American Physiological Society—Porter Fellow- Marie Egan, Peter Glazer, W. Mark Saltzman, vention and Control Policies, 11 months, $232,866 Michael Paidas, BioIncept (nih), Treatment of ship Award, 1 year, $28,300 • Stephen Strittmat- Cystic Fibrosis Foundation Therapeutics (cfft), Mark Horowitz, Maine Medical Center Research Acute Radiation Syndrome Using pif, a Natural ter, University of Washington, Seattle (nih), Gene Editing using Nanoparticles with Triplex- Institute (nih), Interdisciplinary Study of Marrow Immune Modulator, 1 year, $175,525 • A Paltiel, National Alzheimer’s Coordinating Center, 1 year, Forming pnas, 2 years, $334,263 • Sukru Emre, Adiposity, Mineral Metabolism and Energy Massachusetts General Hospital (nih), Novel $26,780; lam Therapeutics, Regulation of AB Pro- University of Texas Southwestern Medical Center Balance, 1 year, $421,846 • Karen Hirschi, Con- Methods to Inform hiv/TB Clinical Trial Develop- duction through Endocytosis, 6 months, $20,000; at Dallas (nih/dhhs), A Multi-Center Group to necticut Innovations, Generation of Human ment, 1 year, $68,796; Massachusetts General Dr. Ralph & Marian Falk Med. Res. Trust, Validation Study Acute Liver Failure, 5 years, $97,767 • Irina Hemogenic Endothelial Cells, 3 years, $750,000 Hospital (nih), The Cost-Effectiveness of Prevent- of Targets to Rescue Synapse Loss in Alzheimer’s Esterlis, Nancy Taylor Foundation for Chronic Dis- Yingqun Huang, American Diabetes Association, ing hiv Complications, 1 year, $30,869 • Jose Disease, 1 year, $485,000 • Stephen Strittmatter, eases, Validation of Methods to Image Ketamine- Mechanism of H19 Long Noncoding rna-Medi- Panisello, Hamad Medical Corporation, Noaf al- Jeffery Kocsis, Marc Hammarlund, William Induced Changes in the Human Brain, 3 years, ated Regulation of Glucose Metabolism, 3 years, Mahmoud Training Program, 1 year, $176,216 Cafferty, Dr. Ralph & Marian Falk Med. Res. Trust, $547,525 • James Farrell, American Association $348,500 • Yasuko Iwakiri, State of Conn. Dept. of Xenophon Papademetris, Electrical Geodesics Medical Therapy to Promote Neural Repair and for Cancer Research, caps Multicenter Trial: Public Health, Type 2 Diabetes and Non-Alcoholic (nih), Multimodal Image Analysis Software for Epi- Functional Recovery from Spinal Cord Injury, Imaging and Markers for Pancreatic Cancer Fatty Liver Diseases, 2 years, $295,550 • Akiko lepsy, 1.5 years, $49,570 • Chirag Parikh, Johns 2 years, $1,000,000 • Reshef Tal, American Screening, 1 year, $30,000 • Richard Flavell, Iwasaki, FluGen (nih), Restimulating Memory T Hopkins University (nih), Biomarkers of Kidney Society for Reproductive Medicine, The Role of Connecticut Innovations, A Mouse Model of the Cell Responses in Elderly by a Novel, Live Influenza Injury to Predict aki Onset and Progression in hiv Endothelial Progenitor Cells in Implantation, Human Immune System, 1.7 years, $500,000; Vaccine, 1 year, $134,998 • Ayana Jordan, Ameri- Infection, 1 year, $45,906 • Sangbum Park, Con- Placentation and Early Pregnancy Development, Benaroya Research Institute (nih), Study of Innate can Psychiatric Association (samhsa), apa/Sub- necticut Innovations, Understanding Mechanism 1 year, $15,000 • William Tamborlane, Helmsley Immune Cells and Development of a Humanized stance Abuse & Mental Health Services Adminis- of Tissue Repair by Live Imaging, 2 years, Charitable Trust, The Leona M. and Harry B., Mouse Model of Scleroderma, 1 year, $83,417 tration Fellowship, 1 year, $26,058 • Christoph $200,000 • Abhijit Patel, Honorable Tina Improving Family Management and Glycemic Liana Fraenkel, Rheumatology Research Founda- Juchem, Race to Erase MS, (formerly The Nancy Brozman Foundation, Ultrasensitive Detection of Control in Youth < 8 years old with Type 1 Diabetes, tion, Preference Phenotypes to Support Dyadic Davis Foundation for Multiple Sclerosis), 1H-MR Tumor dna in Blood for Early Diagnosis of Ovarian 1 year, $98,923 • Jeffrey Testani, Medical Univer- Decision Making in Rheumatoid Arthritis, 2 years, Spectroscopy Markers Sensitive to De- and Remy- Cancer, 2 years, $200,000; Honorable Tina sity of South Carolina, Yale-musc Collaboration $401,252 • Lisa Fucito, Medical University of elination: Yale – Juchem A Longitudinal Pilot Study Brozman Foundation, Tina Brozman Ovarian with Dr. Meredith Brisco, 1 year, $39,866 • Mary South Carolina (nih/dhhs), Novel Treatment to of Acute Multiple Sclerosis Lesions at 7 Tesla, Cancer Planning Grant Agreement, 1.2 years, Tinetti, American Federation for Aging Research, Enhance Smoking Cessation before Cancer 1 year, $75,000 • Amanda Kallen, American $15,000 • Melinda Pettigrew, Duke University John A. Hartford Foundation’s Center of Excel- Surgery, 1 year, $162,214 • Aileen Gariepy, Society Society for Reproductive Medicine, Reproductive (nih), Antibacterial Resistance Leadership Group lence in Geriatric Medicine and Training, 1 year, of Family Planning, Serious Games for Serious Scientist Development Program, 1 year, $10,000 (arlg), 1 year, $34,079 • Robert Pietrzak, Icahn $106,000; John A. Hartford Foundation, Carealign: Issues: Reducing High-Risk Sexual Behavior in Naftali Kaminski, University of Pittsburgh (nih), School of Medicine at Mount Sinai (ismms) (cdc/ Patient Goal-Directed Care for Older Adults with Adolescents through a Mobile Game App, Network Management Core (nemo) for the Pul- dhhs), Gene Expression Profiles as Markers of Multiple Chronic Conditions Achieved through 5 months, $22,199 • Joel Gelernter, Kennedy monary Trials Cooperative (ptc), 1 year, $11,858 ptsd Risk and Resilience in wtc Responders, 1 year, Primary/Specialty Care Alignment, 3 years, Krieger Institute (nih/dhhs), A gewis Study of Barbara Kazmierczak, University of Maryland $4,697 • Margaret Pisani, Patrick and Catherine $3,889,741; Robert Wood Johnson Foundation, Smoking, Hazardous Drinking, and Other Health (nih), Catheter Associated Urinary Tract Infection Weldon Donaghue Medical Research Foundation, Patient Goals Directed Care: High Value Care for Risk Behaviors, 1 year, $104,092; Kennedy Krieger by Pseudomonas Aeruginosa, 3 years, $94,063 Nocturnal Ambient Protection Protocol (napp) to Persons with Multiple Chronic Conditions, 3 years, Institute (nih/dhhs), Risk and Resilience in Mal- Richard Kibbey, Poxel SA, Characterization of the Improve Patient Sleep in the icu, 1 year, $200,000 $414,751 • Richard Torres, Applikate Technologies treated Children, 1 year, $47,345 • Jean-Francois Mechanism of Action Imeglimin-Stimulated Christopher Pittenger, Brain & Behavior Research (nih), A New Approach to Fast, Diagnostic-Quality, Geschwind, Threshold Pharmaceuticals, The Pre- Insulin Secretion, 6 months, $88,245; Pfizer Inc., Foundation (formerly narsad), Translational Bio- Intraoperative Microscopic Examination, 1 year, clinical Study of TH-302 Combined with deb-tace U.S. Pharmaceuticals Group, Flux-Based LC/MS markers in an Animal Model of Tic Disorders, $39,345 • Victoria Ulrich, American Heart Associa- in a Rabbit Model of Liver Cancer, 1.5 years, Screening Platform for Cellular Metabolism: Appli- 2 years, $100,000 • Angelica Ponguta, Fundacion tion (Founders Affiliate), The Role of miR-29 in Ath- $96,456; Boston Scientific Corporation, Paclitaxel- cation to khk, 2 years, $250,000; Eli Lilly and Saldarriaga Concha, fsc Evaluation Framework, erosclerosis and Plaque Composition, 2 years, Eluting-Beads Transarterial Chemoembolization Company, Identification of the Metabolic Fluxes 1 month, $35,000 • Yibing Qyang, Connecticut $94,600 • Flora Vaccarino, Mayo Clinic of Roches- using Oncospheres in a Rabbit VX2 Liver Cancer for Pancreatic Islet Health and Function, 2 years, Innovations, Targeted Investigation into the ter (nih), Discovering the Spectrum of Natural Model, 1.3 years, $400,000; Philips Healthcare, $265,000 • Kenneth Kidd, Defense Intelligence Causes and Amelioration of Vascular Proliferative Somatic Mosaicism in Human Skin Fibroblasts, Exhibit B-10 Specific Research Plan for Image- Agency, Next-Generation dna Sequencing (ngs) Disease Using Patient-Derived Induced Pluripo- 1 year, $40,749 • Christopher Van Dyck, Alzheim- Guided Interventional Oncology: Plan, See, Reach, Technology for Enhanced Human Forensics, tent Stem Cells, 4 years, $750,000 • Marcela er’s Association, Longitudinal Evaluation of Treat and Assess Project, 7 years, $1,050,000 10 months, $347,222 • Anthony Koleske, Ariad Reyna, American Thyroid Association, The Role of Amyloid Risk and Neurodegeneration—The learn Emily Gilmore, American Academy of Neurology, Pharmaceuticals, Influence of Ponatinib on the Renal Na+/I- Symporter (nis) in Iodide Metab- Study, 1 year, $639,000 • Silvia Vilarinho, American Understanding Potentially Harmful eeg Patterns in Rho:rock Signaling as a Contributing Mechanism olism and Thyroid Function, 3 years, $57,500 Association for the Study of Liver Diseases Patients with Acute Brain Injury and Critical for Vascular Occlusion, 1 year, $125,000 • Diane David Rimm, The Nat’l Comprehensive Cancer (aasldf), Delineating Genetic Underpinnings of Illness, 2.2 years, $130,000 • Emily Goldberg, Krause, Connecticut Innovations, Regenerative Network, nccn Institutional Research Agreement, Biliary Atresia, 2 years, $150,000 • Merceditas American Federation for Aging Research, Impact Medicine for Hypoparathyroidism, 3 years, 1 year, $72,214; Breast Cancer Research Founda- Villanueva, University of Massachusetts (dhhs), of Ketone Metabolites on Age-Related Inflamma- $750,000 • Martin Kriegel, Benaroya Research tion, Targeted and Immune Therapies in Breast aids Education and Training Center’s Program tion, 1 year, $51,000 • Jose Gomez Villalobos, Institute (nih), Shaping of the Human Gut Micro- Cancer, 1 year, $250,000 • Douglas Rothman, Cure (neaetc), 1 year, $283,461 • Emily Wang, Patient- Flight Attendant Medical Research Institute, biome by an Autoimmune Risk Allele, 1 year, Huntington’s Disease Institute Foundation (chdi), Centered Outcomes Research Institute, The Share A 3-Gene Signature in Smoking Exposure and $124,875 • Robert LaMotte, Johns Hopkins Uni- Effects of Pan-htt Knockdown on Recently Project: Building Capacity of Former Prisoners, Asthma, 1 year, $108,500 • Andrew Goodman, versity (nih), Peripheral Neuronal Mechanisms of Identified 13C and 1H mrs Flux-Based Biomarkers Criminal Justice Policymakers, and Researchers to Burroughs Wellcome Fund, Resilience of the Itch, 1 year, $100,459 • Alexandra Lansky, Xin of Mitochondrial Energetics and Neurotransmitter Collectively Transform Healthcare Delivery, Human Gut Microbiota During Infection, 5 years, Zhao, Boston Scientific Corporation, Boston Cycling in Huntington’s Disease, 1 year, $243,074; 1.7 years, $255,090 • Stephen Waxman, Paralyzed $500,000 • Steven Gore, University of Michigan Scientific, Training Fellowship Grant for Xin Cure Huntington’s Disease Institute Foundation Veterans of America, Role of Glial Scarring after (nih/dhhs), Epigenetic Biomarkers of Response to Zhao, 1.3 years, $100,000 • Karel Liem, American (chdi), Effects of Transgenic Nrf2 -are Enhance- Injury to the Central Nervous System, 1 years, Azacytidine in Myelodysplastic Syndromes, Society of Nephrology, Characterization of a ment on Recently Identified 13C and 1H mrs Flux- $99,302 • Li Wen, Juvenile Diabetes Research 10 months, $41,625 • Valentina Greco, Edward Jr. Novel Mouse Model of Ciliopathic Cystic Renal Based Biomarkers of Mitochondrial Energetics and Foundation International, Study of Oral Microbiota Mallinckrodt Foundation, Understanding the Disease, 2 years, $200,000 • Joseph Lim, Patient- Neurotransmitter Cycling in Huntington’s Disease, in Prediction of T1D Development, 1 year, $110,000 Malignant Behaviors that Lead to Cancer, 4 years, Centered Outcomes Research Institute, Patient 11 months, $244,884 • Joel Rozowsky, University Sandra Wolin, State of Conn. Dept. of Public $400,000 • Ashima Gulati, American Society of Reported Outcomes Project of hcv-target (prop of California, Los Angeles (ncats/nih), Clinical Health, A Novel Pathway that May Protect Against Nephrology, Ben J. Lipps Research Fellowship up target), 1 year, $36,890 • Erika Linnander, Utility of Salivary Exrna Biomarkers for Gastric Development of Sunlight-Induced Cancers, 2 years, Program, 2 years, $100,000 • Shangqin Guo, Global Environment & Technology Foundation, Cancer Detection, 10 months, $19,553 • Mehran $264,720 • Dianqing Wu, Hai Wu, Connecticut Gilead Sciences, Molecular Definition of Leukemia The Last Mile Partnership: Building Capacity to Sadeghi, State of Conn. Dept. of Public Health, Innovations, Development of Anti-Colorectal Cell-of-Origin, 2 years, $130,000 • Abha Gupta, Save Lives, 5 years, $740,353; Bill and Melinda Molecular Imaging of the Lung, 2 years, $327,430 Cancer Immunobiologics, 2.5 years, $500,000 Connecticut Innovations, Human ipsc Modeling of Gates Foundation, Building and Sustaining Perfor- Lauren Sansing, State of Conn. Dept. of Public Minzhi Xing, Society of Interventional Radiology Autism-Associated Mutations in the Gene chd8, mance Management Capacity in Uttar Pradesh Health, Immunomodulation to Enhance Recovery (sir) Foundation, Interventional Radiology-Based 2 years, $200,000 • Namita Gupta, Pharmaceuti- and Bihar, 7 months, $157,474 • Chi Liu, Philips after Intracerebral Hemorrhage, 2 years, $188,053 Multidisciplinary Management versus Endoscopic cal Research & Manufacturers of America Healthcare, Specific Research Plan for Imaging Nicola Santoro, Allen Foundation, Interactive Management of Malignant Biliary Obstruction: (PhRMA) Foundation, Probing Adaptive Immunity Small Lesions using a Prototype Photon Counting Effect Between Diet and Gut Flora in the Develop- A Comparative and Cost-Effectiveness Population by Computational Analysis of B Cell Repertoire CT System, 2.1 years, $211,728 • Patricia LoRusso, ment of Fatty Liver in Obese Children, 2 years, Study, 1 year, $30,000 • Xiao Xu, University of Sequencing Data, 2 years, $40,000 • David Hafler, Leidos Biomedical Research (Formerly saic Fred- $74,350 • Maor Sauler, Flight Attendant Medical Pennsylvania (nih), Testing a Latino Web-Based GE Global Research (dhhs), Development of erick) (nci/nih), nci 9767 An Open Label, Multi- Research Institute, ddt-CD74: A Novel Signaling Parent-Adolescent Sexual Communication Inter- Sample Sparing Assays for Monitoring Immune center, Single Arm Phase II Study to Evaluate the Pathway that May Protect Against Emphysema, vention, 1 year, $19,596 • Hitten Zaveri, Triton Responses (U24), 11 months, $73,568; Nancy Activity and Tolerability of the Novel mtor Inhibi- 1 year, $108,500 • Kurt Schalper, Lung Cancer Systems (DoD), Cortical Modem Systems Integra- Taylor Foundation for Chronic Diseases, Human tor, mln0128, in Patients with Locally Advanced or Research Foundation, Quantitative Analysis of the tion and Packing, 5 months, $12,514 • David Genetic Variation in Cytokine Signaling Pathways Metastatic Transitional Cell Carcinoma of the PD-1 Axis Components and Immune Infiltrates in Zenisek, University of Texas (nih), Mechanisms of and Susceptibility to Autoimmune Disease, Urothelial Tract Whose Tumors Harbor a tsc1 Lung Cancer: Predictive Role and Therapeutic Neurotransmission in Vertebrate Retina, 1 year, 2 years, $230,000 • Mihaly Hajos, Forum Pharma- and/or a tsc2 mutation, 1.1 years, $120,586 • Jun Implications, 1 year, $75,000 • Michael Schilsky, $42,364 • Jiangbing Zhou, American Heart Associ- ceuticals (Formerly En Vivo Pharmaceuticals), Lu, Connecticut Innovations, Novel Insights and Wilson Disease Association, Wilson Disease ation (Founders Affiliate), Glyburide-Loaded Evaluation of Encenicline, an a7 Nicotinic Acetyl- Approaches toward Accelerated Hematopoietic Biotech Associate, 7 months, $15,000 • Joseph Nanoparticles for Stroke Treatment, 3 years, choline Receptor Agonist on Hippocampal Regeneration, 4 years, $750,000 • Xiaomei Ma, Schlessinger, Gilead Sciences, Gilead-Yale Collab- $198,000 • Jiangbing Zhou, Joseph Piepmeier, Neurophysiology, 1 year, $151,197; H. Lundbeck, University of California, Berkeley (nih), Center for oration in Cancer—Functional Analysis of New Connecticut Innovations, Patient Specific Neural Developing In Vivo Efficacy Assays for Testing Integrative Research on Childhood Leukemia and Cancer Targets, 2 years, $2,300,700 • Nenad Stem Cell Mediated Combination Therapy for 5-HT6 Receptor Antagonists in app/PS1 the Environment—Project 1, 9 months, $76,585 Sestan, Boston University (nih), Heterogeneity of Malignant Gliomas, 4 years, $750,000

Medicine@Yale September/October 2016 7 Two on medical school faculty named to U.K.’s Royal Society Professors of pharmacology Lemmon has studied Center’s pharma- He has shown that axons, synaps- the signaling mecha- cology department es and neurotransmitters are overpro- and neuroscience receive nisms of cell surface under the mentor- duced before declining to adult levels Society memberships receptor tyrosine ship of Joseph by a process of competitive selective kinases (Rtks) Schlessinger, Ph.d., elimination, and added insight into Two Yale scientists have been that, when mutated, now chair of genetic and environmental causes of named to the Royal Society, the cause cancers and pharmacology and congenital brain disorders. United Kingdom’s national acad- other diseases. William H. Prusoff Rakic was recruited to Yale from emy of science. Mark A. Lemmon, His findings are Mark Lemmon Pasko Rakic Professor of Phar- Harvard’s faculty by George Palade ph.d., the David A. Sackler Pro- helping to guide macology at Yale. in 1979, to establish what then was fessor of Pharmacology and co- clinical decisions on which treat- Lemmon was the George W. called the Section of Neuroanatomy. director of the Yale Cancer Biology ment best suits each individual Raiziss Professor of Biochemistry In 2001 the section became the De- Institute, has been elected a Fellow. patient. They bring biochemistry and and Biophysics and department chair partment of Neurobiology, which he Pasko Rakic, m.d., ph.d., the Dorys structural biology into personalized at the University of Pennsylvania continued to chair until 2015 when it McConnell Duberg Professor of medicine by explaining the variety Perelman School of Medicine before became the Department of Neurosci- Neuroscience and professor of of ways in which different mutations he returned to Yale in 2015. ence. Rakic also founded the Kavli neurology, is one of only 10 newly activate the cancer-related proteins in Throughout his distinguished ca- Institute for Neuroscience at Yale and chosen Foreign Members. which they are found. reer, Rakic has dedicated himself to remained its director until 2015. The Society recognizes Lemmon’s In the early 1990s, Lemmon brain development research. The So- His honors include membership in research into basic biochemistry pursued M.s. and Ph.d. degrees in ciety commends his insights into the the National Academy of Sciences, the and biophysics questions, which has molecular biophysics and biochemis- cellular and molecular mechanisms National Academy of Medicine, and yielded significant insights within try at Yale with Donald Engelman. of neuronal proliferation, migration, the American Academy of Arts and the fields of cell signaling and cancer He completed his postdoctoral stud- and synaptogenesis that occur during Sciences. In 2008, he was awarded the research. For much of his career, ies at New York University Medical the evolution of the cerebral cortex. inaugural Kavli Prize in Neuroscience. National Academy of Sciences taps professor for research breadth Frederick J. Sigworth, Ph.D., professor Sigworth’s research unravels the and anti-epileptic says Sigworth’s work advancing new of cellular and molecular physiology, workings of ion channel proteins, the drugs, as well as methods in electron microscopy is an and of biomedical engineering, has “molecular machines” that switch snake and spider example of “the depth and breadth of been elected to the National Academy on and off electrical currents that toxins, all act on scientific inquiry going on at Yale.” of Sciences (nas) in recognition of his are carried by ions across biological ion channels. Such Sigworth will be formally distinguished and continuing achieve- membrane proteins. His lab at Yale is disorders as cystic inducted at next year’s nas annual ments in original research. pursuing new approaches to obtain fibrosis, cardiac meeting. The nas is a private, non- He is among 84 new members and 3D structures of these proteins. arrhythmias, and profit institution established under 21 foreign associates from 14 countries According to Sigworth, ion chan- Frederick Sigworth certain forms of a congressional charter signed by selected for membership. The new mem- nels have a special significance to hypertension and President Abraham Lincoln in 1863. bers were announced May 3. Election to multiple areas of inquiry. They are kidney disease all arise from ion Its charge is providing independent, membership in the Academy is consid- best known, he notes, for their role in channel defects. objective advice to the nation on ered one of the highest honors that can be the electrical activity of nerve cells, Steven M. Girvin, Ph.D., deputy matters that are related to science afforded to a U.S. scientist or engineer. but diabetes medications, novocaine provost for science and technology, and technology.

// Professorship (from page 1) approach, He would found and manage five Amanda never needed to take a O’Connor has been a consul- published in 2003 in Archives of Inter- biopharmaceutical companies that medical leave during treatment, she tant to the White House Office of nal Medicine. have a combined market value of over recalls. Her clinicians cheered her on National Drug Control Policy and Dan Adams’ relationship with $70 billion. Adams saw vaccines as to success throughout her four years co-hosted a White House sympo- Yale had an unusual beginning. He a tremendous business opportunity, as she played varsity ice hockey, a sium on addiction last year. He will was accepted to Yale College but because manufacturing methods family passion. “Everyone was won- speak there again this fall. He has chose Cornell, where he majored in cried out to be modernized and derful, across the board,” she says. been president of the Association chemistry and minored in physics. “vaccines are the most efficient form Now, O’Connor and Dan Adams have for Medical Education and Re- It was, he says, an act of “adolescent of health care,” he says. adjacent seats at Yale hockey games. search in Substance Abuse, and is rebellion” against a father who dearly Amanda Adams did attend Yale O’Connor’s career has been strongly a founding director and past presi- wished for him to go to Yale. He later College, and her time there was rooted at Yale. He came to the School dent of the American Board of earned a law degree from New York eventful. She was diagnosed with of Medicine in 1986 as a Robert Wood Addiction Medicine. University and practiced law on Wall cancer during her freshman year. Johnson Clinical Scholar. He received The medical school’s section of Street, but after a tour as an Army Vincent T. DeVita Jr., m.d., the his m.p.h. from the School of Public general internal medicine has grown captain and company commander in Amy and Joseph Perella Professor of Health after first earning a medical de- dramatically through O’Connor’s Southeast Asia during the Vietnam Medicine and professor of epidemiol- gree at the Albany Medical College and recruitment of talented physician- War he decided he was better suited ogy, and then director of Yale Cancer completing a residency at the Univer- scientists and clinician educators, and its to running companies. Center, took charge of her case. sity of Rochester School of Medicine. research portfolio has grown tenfold.

New Appointments Eight professors have been named to established endowed professorships.

Haifan Lin, ph.d., Stephan Ariyan, Tian Xu, ph.d., Akiko Iwasaki, Craig Russell David G. Schatz, Jeannette R. Christian Tschudi, becomes Eugene m.d., m.b.a., has becomes C.N.H. ph.d., has been Roy, ph.d., is now ph.d., becomes Ickovics, ph.d., is ph.d., has been Higgins Professor been named the Long Professor of named Waldemar Waldemar Von Waldemar Von now the Samuel named the John of Cell Biology. Frank F. Kanthak Genetics. He also Von Zedtwitz Zedtwitz Profes- Zedtwitz Profes- and Liselotte Her- Rodman Paul Lin also is a profes- Professor of Sur- is a professor of Professor of sor of Microbial sor of Immuno- man Professor of Professor of sor of genetics gery. In addition, neuroscience. Immunobiology. Pathogenesis. Roy biology. Schatz is Social and Behav- Epidemiology in and of obstetrics, he is a professor Iwasaki is also is a professor of also professor of ioral Sciences in the Yale School of gynecology, and of dermatology. a professor of immunobiology. molecular biophys- the Yale School of Public Health. reproductive sci- molecular, cellular ics and biochem- Public Health. ences; and director and developmen- istry, and chair of of the Yale Stem tal biology. immunobiology. Cell Center.

8 www.medicineatyale.org