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Medicine@Yale Is Published Four Times Each Year By: Yale School of Medicine, Office of Communications Matthew J

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Medicine@Yale Is Published Four Times Each Year By: Yale School of Medicine, Office of Communications Matthew J September/October 2016 volume 12, issue 2 Advancing Biomedical Science, Education, and Health Care Children, families to benefit doubly from Child Study Center gifts A focus on enhancing parents’ Turning innovative ideas into well-being to better prepare practical therapies and better them to care for their children access to needed care andrew redleaf andrew & When parents seek mental health The Yale Child Study Center (CSC) services for their children, they may has a distinguished history of applying jerry domian be ill equipped to choose the most courtesy lynne scholarship and research to the clinical A gift from the Viola W. Bernard Foundation to the medical school’s Child Study Center will further Ber- A gift from Andrew Redleaf and Lynne Singer Redleaf lets effective approach. Even after they needs of children in New Haven and nard’s vision of turning theory into effective mental the Child Study Center focus new attention on the well- health delivery. With the Center’s director Linda C. have obtained professional help for being of parents as they care for special needs children. Connecticut. Famously, 25 years ago, Mayes (center) are the Foundation’s treasurer Cary a child, they may not realize how the center launched a program that Koplin (left) and its vice president and founder Joan valuable it can be to receive care graduate of Yale College, wanted to encouraged New Haven child mental Wofford, a niece of Bernard. for themselves, both for their own directly contribute to a program dedi- health professionals and police officers well-being and to help them better cated to these challenges. to intervene on behalf of children and it caught the attention of a pioneering address the child’s needs. Lynne recalls that as she raised a families exposed to severe trauma. psychiatrist, Viola W. Bernard, M.D., Spurred by personal experi- son who had emotional and behavioral The initiative, called the Child De- who tirelessly advocated for practi- ences, Lynne Singer Redleaf and her challenges, finding support services velopment-Community Policing Pro- cal solutions for child well-being and husband, Andrew Redleaf, a 1978 near her home in // Parents (page 5) gram (CD-CP), was so successful that health. After her // CD-CP (page 5) Addiction pioneer recognized with professorship Four new leaders to helm medical school Leader of Connecticut-based departments vaccine maker endows chair Four departments at Yale School of for chief of internal medicine Medicine have new leaders. They are Lucian V. Del Priore, m.d., ph.d., As executive chair and head of global of ophthalmology and visual sci- business development at Meriden, ence; Gary V. Desir, m.d., of internal Conn.-based Protein Sciences, Dan medicine; Linda C. Mayes, m.d., of Adams develops and manufactures the Child Study Center; and David G. vaccines. The School of Medicine’s Schatz, ph.d., of immunobiology. Patrick G. O’Connor, m.d., m.p.h., Lucian V. Del Priore became chair chief of general internal medicine, of the Department of Ophthalmol- works to improve treatment for ogy and Visual Science and chief of addiction in primary care settings, harold shapiro Ophthalmology at Yale New Haven Dean Robert J. Alpern (left) hosted a gathering honoring Patrick G. O’Connor (right) as inaugural recipient of where help may be most accessible. an endowed professorship named for Dan Adams and his daughter Amanda Adams (second and third from Hospital (ynhh) on July 1. He was The two men share a commitment right). O’Connor researches innovative ways to treat addiction in primary care and internal medicine settings. recruited from the Medical University to the mission statement of Protein of South Carolina, where he had led Sciences, which reads in part: senior vice president and assistant opioid addiction. That rests solidly the ophthalmology department as the “To save lives and improve health by general counsel at Citicorp, and a 1997 on Patrick’s research.” Pierre G. Jenkins Chair and directed effectively responding to the chang- graduate of Yale College. O’Connor conducted the first the Storm Eye Institute. Del Priore, ing world.” O’Connor’s research focuses on randomized clinical trial of bu- the Robert R. Young Professor of This past spring, in recognition the interfaces among general internal prenorphine for the treatment of Ophthalmology and Visual Science, of that common vision, O’Connor medicine, primary care, and addic- opioid dependence in primary care, specializes in retinal diseases, glau- was named the first Dan Adams and tion. “His internationally renowned published in the American Journal of coma, and vitreoretinal surgery. He Amanda Adams Professor of General work has already made a tremendous Medicine in 1997. He has conducted helped facilitate the first clinical trial Medicine. Dan Adams, a former mem- difference in how drug and alcohol numerous National Institutes of using stem cells to treat patients with ber of the School of Medicine’s Dean’s addictions are treated,” says Robert Health (nih) clinical trials, includ- Stargardt macular dystrophy and Council, created the professorship with J. Alpern, M.D., dean and Ensign ing a randomized trial of naltrexone age-related macular degeneration. a substantial endowment. Professor of Medicine. “Office-based for the treatment of alcohol depen- In 1982, he received his m.d. The endowment honors Amanda treatment with buprenorphine is now dence using a primary care-based with distinction in research from Adams, who is Dan Adams’ daughter, the most common form of therapy for management // Professorship page 8) the University of // Chairs (page 4) Non-Profit Org. INSIDE THIS ISSUE 1 Church St., Suite 300, New Haven, CT 06510-3330 U. S. Postage www.medicineatyale.org 2 Lifelines PAID Alison P. Galvani uses powerful mathemati- New Haven, CT cal models to both predict and change the Permit No. 526 trajectory of deadly infectious disease. 3 Embracing big-data research The new Yale Center for Research Comput- ing has the technology and expertise to help investigators execute their research. 5 NIH renews prestigious funding Benefits of grants from the National Center for Advancing Translational Sciences include funding for junior investigators. FOLLOW & SHARE: twitter.com/YaleMed facebook.com/YaleMed instagram.com/YaleMed lifelines Pathologist named director of tumor profiling lab Alison P. Galvani, the youngest Janina A. Long- person ever appointed to an endowed professorship at the tine, m.d., has medical school, has combined been appointed technology with the power of mathematics to predict patterns vice chair of of deadly infectious disease. pathology and Galvani’s work has changed the trajectory of disease treatment laboratory medi- and prevention. cine and director of molecular and Janina Longtine genomic diag- nostics at Yale School of Medicine and director of the Tumor Profiling Laboratory at Smilow Cancer Hospital. Throughout her 30-year career, Longtine has developed deep expertise in molecular pathol- Alison P. Galvani ogy. In her new role, she plans to harold shapiro integrate patient management and individualized cancer care with tumor profiling services. Longtine The ecology of disease will work with the departments of pathology and laboratory medi- From the flu to Ebola, Robert May. Following a postdoctoral the basis for effective ways to stem cine, in addition to the Center for fellowship at the University of Cali- the epidemic. Their predictions of the Genome Analysis at West Campus, predicting and then fornia, Berkeley, she came to Yale as a impact of combined interventions— to foster integration across mo- stifling pathogens’ spread junior faculty member. By that time her published in the journal Science— lecular diagnostic services within pioneering work in behavioral epidemi- forecast trajectories of the epidemic the medical school. Alison P. Galvani, ph.d., the Burnett and ology—how human behavior leads to in Liberia with remarkable accuracy. Longtine came to Yale this past Stender Families Professor of Epidemiol- and affects disease transmission—was Galvani’s team also developed a spring from Icahn School of Medi- ogy, has devoted her research career to well underway. “I’m fascinated by the smartphone app to track the location cine at Mount Sinai in New York tracking diseases, and to transforming power of mathematics to contribute of symptomatic patients. Previously, where she was tenured professor data into predictive maps and practical in very practical ways to the benefit of with only pencil and paper to do that and vice chair of molecular pathol- policy recommendations. So distin- society,” she says. job, the arrival of ambulances had been ogy and genetics. Before joining guished is her body of work that in 2015, Galvani’s team at Yale has con- delayed by as much as several days. at age 38, Galvani became the youngest- ducted international investigations With resources in Liberia severely Mount Sinai in 2011, Longtine held ever appointee to an endowed profes- into the transmission of hiv, influenza, limited, cidma contributed more than multiple appointments at Brigham sorship at the School of Medicine. Ebola, and Zika, among other patho- 30 computers and phones to the Ebola and Women’s Hospital and Dana- When Galvani was just 5 years gens. “We are most interested in proj- response team so that the mobile Farber Cancer Institute and was old, growing up in San Francisco, her ects that have the potential to improve application could function. Patients associate professor of pathology at mother—a clinical psychologist—died. policy and save lives,” she says. Her received hospital care far more rapidly, Harvard Medical School. According to Galvani, her grief instilled work on influenza and rotavirus has led improving recovery rates and curtailing She studied molecular biology in her an abiding passion for helping to concrete policy changes and made further transmission. at Wellesley College and earned the downtrodden and orphaned. vaccination programs in Israel and the Galvani has received numerous her m.d.
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