Graduate School of Arts and Sciences 2001–2002
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A Scientific Jackpot: the Nobel Prize for Penn Trio a Gentleman Dr
See the back page UNIVERSITY of PENNSYLVANIA for more Tuesday, on the October 17, 2000 Nobel Laureate, Volume 47 Number 8 Alan MacDiarmid. www.upenn.edu/almanac/ Toasting A Chemist and A Scientific Jackpot: The Nobel Prize for Penn Trio A Gentleman Dr. Alan G. MacDiarmid, structure. For a polymer to conduct electric current, it must “A Penn Nobel Blanchard Professor of Chem- consist alternately of single and double bonds between the Prize,”... “based on istry, is one of three recipients carbon atoms. It must also be “doped,” which means that great applied and of the 2000 Nobel Prize in electrons are removed (through oxidation) or introduced basic science,” is Chemistry. Sharing the honor (through reduction). These “holes,” or extra electrons, can how Roy Vagelos are former Penn professor Dr. move along the molecule, making it electrically conductive. described the accom- Alan J. Heeger, now at the Uni- Drs. MacDiarmid, Heeger, and Shirakawa were respon- plishment of “one of versity of California at Santa sible for the 1977 synthesis and the electrical and chemical our best teachers and Barbara, and Dr. Hideki doping of polyacetylene, the prototypical conducting poly- researchers.” Shirakawa, of the University of mer, and the rediscovery of polyaniline, now the foremost Tsukuba in Japan. industrial conducting polymer. They have subsequently de- “It’s an understate- The work underlying the veloped conductive polymers into a research field of great ment that we’ve award—which showed that importance for chemists as well as physicists. The area has been waiting for this plastics can be made to conduct also yielded important practical applications. -
Molecular Dynamics Simulations in Drug Discovery and Pharmaceutical Development
processes Review Molecular Dynamics Simulations in Drug Discovery and Pharmaceutical Development Outi M. H. Salo-Ahen 1,2,* , Ida Alanko 1,2, Rajendra Bhadane 1,2 , Alexandre M. J. J. Bonvin 3,* , Rodrigo Vargas Honorato 3, Shakhawath Hossain 4 , André H. Juffer 5 , Aleksei Kabedev 4, Maija Lahtela-Kakkonen 6, Anders Støttrup Larsen 7, Eveline Lescrinier 8 , Parthiban Marimuthu 1,2 , Muhammad Usman Mirza 8 , Ghulam Mustafa 9, Ariane Nunes-Alves 10,11,* , Tatu Pantsar 6,12, Atefeh Saadabadi 1,2 , Kalaimathy Singaravelu 13 and Michiel Vanmeert 8 1 Pharmaceutical Sciences Laboratory (Pharmacy), Åbo Akademi University, Tykistökatu 6 A, Biocity, FI-20520 Turku, Finland; ida.alanko@abo.fi (I.A.); rajendra.bhadane@abo.fi (R.B.); parthiban.marimuthu@abo.fi (P.M.); atefeh.saadabadi@abo.fi (A.S.) 2 Structural Bioinformatics Laboratory (Biochemistry), Åbo Akademi University, Tykistökatu 6 A, Biocity, FI-20520 Turku, Finland 3 Faculty of Science-Chemistry, Bijvoet Center for Biomolecular Research, Utrecht University, 3584 CH Utrecht, The Netherlands; [email protected] 4 Swedish Drug Delivery Forum (SDDF), Department of Pharmacy, Uppsala Biomedical Center, Uppsala University, 751 23 Uppsala, Sweden; [email protected] (S.H.); [email protected] (A.K.) 5 Biocenter Oulu & Faculty of Biochemistry and Molecular Medicine, University of Oulu, Aapistie 7 A, FI-90014 Oulu, Finland; andre.juffer@oulu.fi 6 School of Pharmacy, University of Eastern Finland, FI-70210 Kuopio, Finland; maija.lahtela-kakkonen@uef.fi (M.L.-K.); tatu.pantsar@uef.fi -
Dossier De Presse
Atypik Films Présente Patrick Ridremont François Berléand Virginie Efira DEAD MAN TALKING Un film belge de PATRICK RIDREMONT (Durée : 1h41) Distribution Relations Presse Atypik Films Laurence Falleur Communication 31 rue des Ombraies 57 rue du Faubourg Montmartre 92000 Nanterre 75009 Paris Eric Boquého Laurence Falleur Assisté de Sandrine Becquart Assisté de Vincent Bayol Et Jacques Domergue Tel : 01.83.92.80.51 Tel : 01.77.68.32.16. Port. : 06.48.89.41.29 Port. : 06.62.49.19.87. [email protected] [email protected] [email protected] Matériel de presse téléchargeable sur www.atypikfilms.com SYNOPSIS William Lamers , 40 ans, anonyme criminel condamné au Poison pour meurtre, se prépare à être exécuté. La procédure se passe dans l’indifférence générale et, ni la famille du condamné, ni celle de ses victimes n’a fait le déplacement pour assister à l’exécution. Seul le journaliste d’un minable tabloïd local est venu assister au «spectacle». Pourtant ce qui ne devait être qu’une formalité va rapidement devenir un véritable cauchemar pour Karl Raven, le directeur de la prison. Alors qu’on lui demande s’il a quelque chose à dire avant de mourir, William se met à raconter sa vie, et se lance dans un récit incroyable et bouleversant. Raven s’impatiente et appelle le Gouverneur Brodeck pour obtenir l'autorisation d'exécuter William. Mais comme la loi ne précise rien sur la longueur des dernières paroles et que le Gouverneur Stieg Brodeck, au plus bas dans les sondages, ne peut prendre aucun risque à un mois des élections, on décide de laisser William raconter son histoire jusqu’au bout. -
Course Catalogue 2016 /2017
Course Catalogue 2016 /2017 1 Contents Art, Architecture, Music & Cinema page 3 Arabic 19 Business & Economics 19 Chinese 32 Communication, Culture, Media Studies 33 (including Journalism) Computer Science 53 Education 56 English 57 French 71 Geography 79 German 85 History 89 Italian 101 Latin 102 Law 103 Mathematics & Finance 104 Political Science 107 Psychology 120 Russian 126 Sociology & Anthropology 126 Spanish 128 Tourism 138 2 the diversity of its main players. It will thus establish Art, Architecture, the historical context of this production and to identify the protagonists, before defining the movements that Music & Cinema appear in their pulse. If the development of the course is structured around a chronological continuity, their links and how these trends overlap in reality into each IMPORTANT: ALL OUR ART COURSES ARE other will be raised and studied. TAUGHT IN FRENCH UNLESS OTHERWISE INDICATED COURSE CONTENT : Course Outline: AS1/1b : HISTORY OF CLASSIC CINEMA introduction Fall Semester • Impressionism • Project Genesis Lectures: 2 hours ECTS credits: 3 • "Impressionist" • The Post-Impressionism OBJECTIVE: • The néoimpressionnism To discover the great movements in the history of • The synthetism American and European cinema from 1895 to 1942. • The symbolism • Gauguin and the Nabis PontAven COURSE PROGRAM: • Modern and avantgarde The three cinematic eras: • Fauvism and Expressionism Original: • Cubism - The Lumière brothers : realistic art • Futurism - Mélies : the beginnings of illusion • Abstraction Avant-garde : - Expressionism -
Stéphane Braunschweig Théâtre De L'odéon- 6E
de Molière 17 septembre 25 octobre 2008 mise en scène & scénographie Stéphane Braunschweig Théâtre de l'Odéon- 6e costumes Thibault Vancraenenbroeck lumière Marion Hewlett son Xavier Jacquot collaboration artistique Anne-Françoise Benhamou collaboration à la scénographie Alexandre de Darden production Théâtre national de Strasbourg créé le 29 avril 2008 au Théâtre national de Strasbourg avec Monsieur Loyal : Jean-Pierre Bagot Cléante : Christophe Brault Tartuffe : Clément Bresson Valère : Thomas Condemine Orgon : Claude Duparfait Mariane : Julie Lesgages Elmire : Pauline Lorillard Dorine : Annie Mercier Damis : Sébastien Pouderoux Madame Pernelle : Claire Wauthion et avec la participation de l’exempt : François Loriquet Rencontre Spectacle du mardi au samedi à 20h, le dimanche à 15h, relâche le lundi Au bord de plateau jeudi 2 octobre Prix des places : 30€ - 22€ - 12€ - 7,50€ (séries 1, 2, 3, 4) à l’issue de la représentation, Tarif groupes scolaires : 11€ et 6€ (séries 2 et 3) en présence de l’équipe artistique. Entrée libre. Odéon–Théâtre de l’Europe Théâtre de l’Odéon Renseignements 01 44 85 40 90 e Place de l’Odéon Paris 6 / Métro Odéon - RER B Luxembourg L’équipe des relations avec le public : Scolaires et universitaires, associations d’étudiants Réservation et Actions pédagogiques Christophe Teillout 01 44 85 40 39 - [email protected] Emilie Dauriac 01 44 85 40 33 - [email protected] Dossier également disponible sur www.theatre-odeon.fr Certaines parties de ce dossier sont tirées du dossier pédagogique et du programme réalisés par l’équipe du Théâtre national de Strasbourg. Collaboration d’Arthur Le Stanc Tartuffe / 17 septembre › 25 octobre 2008 1 Oui, je deviens tout autre avec son entretien, Il m'enseigne à n'avoir affection pour rien ; De toutes amitiés il détache mon âme ; Et je verrais mourir frère, enfants, mère, et femme, Que je m'en soucierais autant que de cela. -
Open Ratulchowdhury Etd.Pdf
The Pennsylvania State University The Graduate School COMPUTATIONAL REDESIGN OF CHANNEL PROTEINS, ENZYMES, AND ANTIBODIES A Dissertation in Chemical Engineering by Ratul Chowdhury © 2020 Ratul Chowdhury Submitted in Partial Fulfillment of the Requirements for the Degree of Doctor of Philosophy May 2020 The dissertation of Ratul Chowdhury was reviewed and approved* by the following: Costas D. Maranas Donald B. Broughton Professor of Chemical Engineering Dissertation Advisor Chair of Committee Manish Kumar Assistant Professor in Chemical Engineering Michael Janik Professor in Chemical Engineering Reka Albert Professor in Physics Phillip E. Savage Department Head and Graduate Program Chair Professor in Chemical Engineering ii ABSTRACT Nature relies on a wide range of enzymes with specific biocatalytic roles to carry out much of the chemistry needed to sustain life. Proteins catalyze the interconversion of a vast array of molecules with high specificity - from molecular nitrogen fixation to the synthesis of highly specialized hormones, quorum-sensing molecules, defend against disease causing foreign proteins, and maintain osmotic balance using transmembrane channel proteins. Ever increasing emphasis on renewable sources for energy and waste minimization has turned biocatalytic proteins (enzymes) into key industrial workhorses for targeted chemical conversions. Modern protein engineering is central to not only food and beverage manufacturing processes but are also often ingredients in countless consumer product formulations such as proteolytic enzymes in detergents and amylases and peptide-based therapeutics in the form of designed antibodies to combat neurodegenerative diseases (such as Parkinson’s, Alzheimer’s) and outbreaks of Zika and Ebola virus. However, successful protein design or tweaking an existing protein for a desired functionality has remained a constant challenge. -
12TH ASIAN CHEMICAL CONGRESS (12ACC) 2007 Registration Form
No. 1 / 2007 ■ Kuwait Chemical Society Symposium on Application of Catalyst in the Industry ■ 2006 Activities and 2007 President Profiles of the Member Societies www.facs-as.org Federation of Asian Chemical Societies Newsletter | No. 1 / 2007 ontents Obituary ■ Dr. Tan Sri B C Sekhar (1929 – 2006) 4 ■ Prof. Hitoshi Ohtaki (1932 – 2006) 6 Special Symposium ■ Kuwait Chemical Society Symposium on Application of Catalyst in the Industry (Fuel, Pollution and Drugs) 9 Biofuels: Emerging Renewable Energy for the Transportation Sector 10 Discrete Physico-Chemical Processes that Characterise Water Pollution 13 Peptide-Cleaving Catalyst as a New Paradigm in Drug Discovery 16 2006 Activities and 2007 President Profiles of the Member Societies ■ Brunei Darussalam Institute of Chemistry 18 ■ Chinese Chemical Society 20 ■ Hong Kong Chemical Society 22 ■ Institut Kimia Malaysia 23 ■ Korean Chemical Society 27 ■ New Zealand Institute of Chemistry 29 ■ Royal Australian Chemical Institute 32 FACS Activities ■ Minutes of the 49th EXCO Meeting 34 ■ FACS Project Reports Asian Chemicla Education Network (ACEN) 41 Asian Network for Environmental chemistry (ANEC) 42 Low-Cost Instrumentation-Microscale Chemistry (LCI-MSC) 47 Meeting Announcement: The 12th Asian Chemical Congress 49 Directories ■ FACS EXCO Members (2005-2007) 55 ■ Member Societies 56 ■ Project Directors (2006-2007) 58 ■ FACS Fellows 59 ■ FACS Life-time Members 60 An electronic version of FACS Newsletter is available at http://www.facs.org. Obituary The Late Academician Dr. Tan Sri B C Sekhar (1929 – 2006) he Late academician Dr. Tan Sri B C Sekhar, born on November 17, 1929 at Sungai Buloh, Malaysia near the 3,400-acre experiment station of the Rubber Research Institute of Malaysia (RRIM), was fondly known as Mr Natural Rubber for his motivation, passion and commitment to the development of natural rubber industry. -
Recent Advances in Automated Protein Design and Its Future
EXPERT OPINION ON DRUG DISCOVERY 2018, VOL. 13, NO. 7, 587–604 https://doi.org/10.1080/17460441.2018.1465922 REVIEW Recent advances in automated protein design and its future challenges Dani Setiawana, Jeffrey Brenderb and Yang Zhanga,c aDepartment of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI, USA; bRadiation Biology Branch, Center for Cancer Research, National Cancer Institute – NIH, Bethesda, MD, USA; cDepartment of Biological Chemistry, University of Michigan, Ann Arbor, MI, USA ABSTRACT ARTICLE HISTORY Introduction: Protein function is determined by protein structure which is in turn determined by the Received 25 October 2017 corresponding protein sequence. If the rules that cause a protein to adopt a particular structure are Accepted 13 April 2018 understood, it should be possible to refine or even redefine the function of a protein by working KEYWORDS backwards from the desired structure to the sequence. Automated protein design attempts to calculate Protein design; automated the effects of mutations computationally with the goal of more radical or complex transformations than protein design; ab initio are accessible by experimental techniques. design; scoring function; Areas covered: The authors give a brief overview of the recent methodological advances in computer- protein folding; aided protein design, showing how methodological choices affect final design and how automated conformational search protein design can be used to address problems considered beyond traditional protein engineering, including the creation of novel protein scaffolds for drug development. Also, the authors address specifically the future challenges in the development of automated protein design. Expert opinion: Automated protein design holds potential as a protein engineering technique, parti- cularly in cases where screening by combinatorial mutagenesis is problematic. -
AMS Officers and Committee Members
Officers and Committee Members Numbers to the left of headings are used as points of reference 2. Council in an index to AMS committees which follows this listing. Primary and secondary headings are: 2.0.1. Officers of the AMS 1. Officers President James G. Glimm 2008 1.1. Liaison Committee President Elect George E. Andrews 2008 2. Council Vice President Robert L. Bryant 2009 2.1. Executive Committee of the Council 3. Board of Trustees Ruth M. Charney 2008 4. Committees Bernd Sturmfels 2010 4.1. Committees of the Council Secretary Robert J. Daverman 2008 4.2. Editorial Committees Associate Secretaries* Susan J. Friedlander 2009 4.3. Committees of the Board of Trustees Michel L. Lapidus 2009 4.4. Committees of the Executive Committee and Board of Matthew Miller 2008 Trustees Lesley M. Sibner 2008 4.5. Internal Organization of the AMS 4.6. Program and Meetings Treasurer John M. Franks 2008 4.7. Status of the Profession Associate Treasurer Donald E. McClure 2008 4.8. Prizes and Awards 4.9. Institutes and Symposia 4.10. Joint Committees 2.0.2. Representatives of Committees 5. Representatives Bulletin Susan J. Friedlander 2008 6. Index Colloquium Paul J. Sally Jr. 2011 Terms of members expire on January 31 following the year given Executive Committee Sylvain E. Cappell 2009 unless otherwise specified. Journal of the AMS Robert K. Lazarsfeld 2009 Mathematical Reviews Jonathan I. Hall 2008 Mathematical Surveys 1. Officers and Monographs J. Tobias Stafford 2008 Mathematics of President James G. Glimm 2008 Computation Chi-Wang Shu 2011 President Elect George E. -
2020 Research Highlights
2020 RESEARCH HIGHLIGHTS FROM THE SCHOOL OF CHEMICAL SCIENCES A word from the Head The year 2020 presented our School with multiple challenges, yet our teaching and research was able to continue in a sometimes revised form. We have seen research teams and spin-off companies pivot to COVID-19 – related research and development. All our researchers have adapted to working in new environments, including bubbles at Level 3 and decreased laboratory occupancies at Level 2. Staff and students have also maintained their overseas and domestic collaborations and many have found their home offices can be productive writing spaces. We decided that one way we could celebrate our resilience and The School has an international reputation in natural products productivity in research this year was to produce this report chemistry and medicinal peptide chemistry and also in the highlighting our successes. We share the continued successes of development of potential metal-containing anticancer drugs. Our our high-profile researchers such as Distinguished Professor Dame materials chemistry expertise has resulted in the development of gas Margaret Brimble FRS, while also noting the contributions of our sensors which are now being incorporated in reliable sensing networks newest academics, research fellows and PhD students. Our research and photocatalysts. is heading in exciting new directions including new medications, developing novel states of matter, connecting electronics to cells, and Besides the success of individual research groups, our multi- modelling the behaviour of proteins. We support the range of activities investigator programmes and centres provide a foundation for joint from blue skies single investigator-led research to teams focused on funding bids and research publications. -
The Abel Prize Laureate 2017
The Abel Prize Laureate 2017 Yves Meyer École normale supérieure Paris-Saclay, France www.abelprize.no Yves Meyer receives the Abel Prize for 2017 “for his pivotal role in the development of the mathematical theory of wavelets.” Citation The Abel Committee The Norwegian Academy of Science and or “wavelets”, obtained by both dilating infinite sequence of nested subspaces Meyer’s expertise in the mathematics Letters has decided to award the Abel and translating a fixed function. of L2(R) that satisfy a few additional of the Calderón-Zygmund school that Prize for 2017 to In the spring of 1985, Yves Meyer invariance properties. This work paved opened the way for the development of recognised that a recovery formula the way for the construction by Ingrid wavelet theory, providing a remarkably Yves Meyer, École normale supérieure found by Morlet and Alex Grossmann Daubechies of orthonormal bases of fruitful link between a problem set Paris-Saclay, France was an identity previously discovered compactly supported wavelets. squarely in pure mathematics and a theory by Alberto Calderón. At that time, Yves In the following decades, wavelet with wide applicability in the real world. “for his pivotal role in the Meyer was already a leading figure analysis has been applied in a wide development of the mathematical in the Calderón-Zygmund theory of variety of arenas as diverse as applied theory of wavelets.” singular integral operators. Thus began and computational harmonic analysis, Meyer’s study of wavelets, which in less data compression, noise reduction, Fourier analysis provides a useful way than ten years would develop into a medical imaging, archiving, digital cinema, of decomposing a signal or function into coherent and widely applicable theory. -
Medicine@Yale U
@ MedicineAdvancing Biomedical Science, Education and Health Care YaleVolume 4, Issue 3 July/August 2008 Leading scientist is appointed new chair of Cell Biology Membrane traffi c expert and chair of the School of Medicine’s to Yale’s recently protein-coding genes in the human Department of Cell Biology. Roth- opened West Cam- genome, providing fresh insights into will head a department man will come to Yale from Columbia pus in West Haven, disease and new molecular targets for that has shaped the fi eld University’s College of Physicians and Conn., where he will therapy. Under Rothman’s leadership Surgeons, where he is now a professor launch a Center for the Department of Cell Biology will James E. Rothman, F>:, one of the in the Department of Physiology and High-Throughput be signifi cantly expanded, and will be world’s foremost experts on mem- Biophysics, the Clyde and Helen Wu Cell Biology. At the co-located at the West Campus along brane traffi cking, the means by which Professor of Chemical Biology and new center, multi- with its present location at the main proteins and other materials are director of the Columbia Genome +BNFT3PUINBO disciplinary teams campus of the School of Medicine. transported within and between cells, Center. of scientists will develop tools and For his decades of seminal re- has been named the Fergus F. Wal- In addition to directing Cell techniques to rapidly decipher the cel- search on the transport of molecules lace Professor of Biomedical Sciences Biology, Rothman is the fi rst recruit lular functions of the