Scientific Program January 26-27, 2021 All program times in IST time zone (CET+1)

Tuesday, January 26 Hall A 10:15-10:35 Gathering and Exhibition 10:35-12:00 Session 1: Opening Plenary Session Chairs: Haim Shirin; Oren Shibolet 10:35-10:45 Welcome address Haim Shirin Shamir Medical Center (Assaf Harofeh) 10:45-11:30 Hepatitis C: The beginning, the middle and possibly the end (Supported by Gilead) Harvey Alter 2020 Nobel Prize laureate University of Rochester School of Medicine, Rochester, New York, USA 11:30-12:00 IBD Treatment Paradigm – Future Evolution and Agility - LIVE (Supported by Takeda) Laurent Peyrin-Biroulet Gastroenterology Department, Nancy University Hospital, France 12:00-12:15 Break Hall A Hall B 12:15-13:30 Session 2: Neurogastroenterology and Motility 12:15-13:30 Session 3: Obesity Treatment – How? Who? When? Chairs: Chairs: Roy Dekel; Fabiana Benjaminov, Meir Medical Center; Anat Nevo-Shor, Soroka University Medical Center TBA 12:15-12:20 Brief Introduction: Roy Dekel 12:15-12:30 Weight loosing medications: The Israeli status Liat Barzilay Yoseph Endocrinology Department, Meir Medical Center 12:20-12:30 Take a big breath: New Guidelines for the clinical use of Breath Tests – 12:30-12:50 Endoscopic bariatric treatments- Where do we stand? Lessons from The Israeli Consensus Group Reem Sharaiha Ram Dickman Weill Cornell Medicine, Division of Gastroenterology and Hepatological Department of Medicine, New York, USA 12:30-12:45 IBS – What are the underlying mechanisms - an update on IBS 12:50-13:00 Future directions in bariatric endoscopy pathophysiology Ian Gralnek Guy Boeckxstaens Gastroenterology and Hepatology Department, Haemek Medical Center Translational Research Center for GI Disorders (TARGID), University Hospital Leuven

12:45-13:00 IBS – New drugs and future directions What's in the pipeline: what are 13:00-13:15 Panel discussion: Who should treat the obese patient? the most promising new drugs in FGID Panel: Jan Tack Liat Barzilay Department of Gastroenterology University Hospitals Leuven, Belgium Sigal Fishman, Department of Gastroenterology, Sourasky Medical Center Steven Shama, Rabin Medical Center Reem Sharaiha 13:00-13:05 The Israeli Neurogastroenterology Group is here for you: A Practical 13:15-13:22 Endoscopic ultrasound (EUS) guided radiofrequency ablation (RFA) for approach for the treatment IBS – Position paper pancreatic neuroendocrine tumors (pNET): are the results still good when based Roy Dekel on PET-CT ga68 follow up? Sourasky Medical Center, Ichilov Hospital Joel Schifter1; Alain Dancour2; Genadi, Sheykman2; Menachem Ben Haim2; Eran Goldin2; Dan M. Livovsky2 1Shaare Tzedek Medical Center, 2Digestive Diseases Institute Shaare Zedek Medical Center 13:05-13:12 THE NATURAL HISTORY OF ESOPHAGEAL "ABSENT CONTRACTILITY" AND 13:22-13:30 SAFE WITH HIGH CLINICAL IMPACT: PRELIMINARY RESULTS ITS RELATIONSHIP WITH RHEUMATOLOGIC DISEASES: A CASE-CONTROL Dov Wengrower; Mahmoud Mahamid; Eran Goldin STUDY WITH LONG-TERM FOLLOW-UP Digestive Disease Institute,Shaare Zedek Medical Center, affiliated to the Daniel Cohen; Anton Bermont; Vered Richter; Haim Shirin Henrew University Medical School Shamir (Assaf Harofeh) Medical Center 13:12-13:20 POSITIVE FINDINGS ON VIDEO CAPSULE ENDOSCOPY HAS A MINOR LONG-TERM THERAPEUTIC IMPACT IN PATIENTS WITH IRON DEFICIENCY ANEMIA Anton Bermont; Daniel Cohen; Efrat Broide; Vered Rihter; Haim Shirin The Gonczarowski Family Institute of Gastroenterology and Liver Diseases, Shamir Medical Center 13:20-13:30 Live Q&A 13:30-13:45 Break Hall A Hall B 13:45-15:20 Session 4: Hepatology 13:45-15:20 Session 5: IBD Chairs: Chairs: Ayelet Partoush Abbou, Yehuda Chowers, Gastroenterology Department, Rambam Health Care Campus; Rifaat Safadi; Vered Richter, Shamir (Assaf Harofeh) Medical Center 13:45-14:05 How Cholestasis Patients Scratch in 2021? 13:45-14:10 Pre-IBD diagnosis: Why should we do it and where are we now? Rifaat Safadi Johanna Torres Hadassah-Hebrew University Medical Center Division of Gastroenterology, Hospital Beatriz Ângelo, Loures, Portugal 14:05-14:25 Hepatocellular Carcinoma, A Breakthrough After All These Years 14:10-14:35 Current status of combination treatments in IBD (Supported by Roche( Remo Panaccione Oren Shibolet Inflammatory Bowel Disease Clinic, Cumming School of Medicine, University of Tel Aviv Medical Center, Sackler School of Medicine, Tel Aviv University Calgary, Canada 14:25-14:45 Immune Mediated DILI of Biologic Therapies & Checkpoints 14:35-14:55 TBA Assaf Issachar Rabin Medical Center 14:45-14:52 CHRONIC HEPATITIS B INFECTION AND DIABETES MELLITUS: A DOUBLE 14:55-15:02 THE COURSE OF COVID-19 IN IBD PATIENTS TREATED WITH BIOLOGICS LIVER TROUBLE?

Fadi Abu Baker1; Ilan Green2; Gadeer Taha2; Yana Davidov3; Tawfik Lev Lichtenstein1; Benjamin Koslowsky2; Irit Avni-Biron3; Baruch Ovadia4; Ofer Khoury4; Amir Mari4; Yael Kopelman1; Saif Abu Mouch1; Ziv Ben Ari3 Ben-Bassat5; Timna Naftali6; Uri Kopylov7; Yael Haberman-Ziv8; Hagar Banai- 1Hillel Yaffe Meidcal Center, 2Leumit Health Care Services, 3Sheba Eran9; Rami Eliakim7; Adi Lahat-Zok7; Ayal Hirsch10; Eran Zittan11; Nitsan Medical Center, 4EMMS Medical Center Maharshak10; Matti Waterman12; Eran Israeli13; Idan Goren9; Jacob E. Ollech9; Henit Yanai9; Bella Ungar7; Benjamin Avidan7; Dana Ben Hur12; Bernardo Melamud13; Ori Segol14; Zippora Shalem15; Iris Dotan9; Selwyn H. Odes16; Shomron Ben-Horin7; Yf'at Snir9; Yael Milgrom17; Efrat Broide15; Eran Goldin18; Shmuel Delgado19; Yulia Ron10; Nathaniel Aviv Cohen10; Eran Maoz20; Mia Zborovski20; Safwat Odeh21; Naim Abu Freha22; Eyal Shachar7; Yehuda Chowers12; Tal Engel7; Hila Reiss16; Arie Segal22; Adar Zinger17; Ariella Bar-Gil Shitrit2,18 1Ben-Gurion University, 2Hebrew University, 3Tel Aviv University, 4Hillel Yaffe Medical Center, 5Barzilai Medical Center, 6Meir Medical Center, 7The Chaim , 8Safra Medical Center, 9Rabin Medical Center, 10Tel Aviv Sourasky Medical Center (Ichilov), 11Emek Medical Center, 12Rambam Medical Center, 13Wolfson Medical Center, 14Lady Davis Carmel Medical Center, 15Shamir Medical Center (Assaf Harofeh), 16Mayanei HaYeshua Medical Center, 17Hadassah Medical Center, 18Shaare Zedek Medical Center, 19Samson , 20Clalit Health Services, 21Bnai Zion Medical Center, 22Soroka Medical Center 14:52-15:12 HCV Extra Hepatic Manifestations, where are the patients? 15:02-15:12 Position statement of the Israeli IBD society on treatment strategies 2021 (Supported by Abbvie( Henit Yanai Ziv Ben Ari Rabin Medical Center Sheba Medical Center, Sackler School of Medicine, Tel Aviv University 15:12-15:20 ELEVATED PRE COVID-19 FIB-4 AS A GOOD BIOMARKER OF COVID-19 15:12-15:20 EFFECTIVNES OF TOFACITINIB IN A REAL-WORLD ISRAELI COHOT OF PATIENTS INFECTION OUTCOME WITH MODERATE - SEVERE ULCERATIVE COLITIS Yael Milgrom1; Asher Shafrir1; Eliana Meshrky1; David Hakimian1; Irit Avni Biron1; Ariella Bar-Gil Shitrit2; Binyamin Koslowsky2; Assaf Levartovsky3; Mohamad Masarowahr1; Rifaat Safadi1; Michal Shauly-Aharonov2 Ronny Weisshof4; Nathaniel Aviv Cohen5; David Hovel6; Timna Naftali7; Idan 1Hadassah Medical Center, 2Hebrew University Goren1; Ifat Snir1; Hagar Banai1; Jacob Ollech8; Yelena Broytman8; Iris Dotan8; Henit Yanai8 1IBD Center, Division of Gastroenterology, Rabin Medical Center, 2Digestive Diseases Institute, Shaare Zedek Medical Center, 3Department of Gastroenterology and Liver Diseases, Sheba Medical Center, 4Gastroenterology Institute, Rambam Health Care Campus, 5IBD Center, Department of Gastroenterology and Liver Diseases, Tel Aviv Medical Center, 6Department of Gastroenterology and Liver Diseases, Edith , 7Department of Gastroenterology and Liver Diseases, Meir Medical Center, 8IBD Center, Division of Gastroenterology, Rabin Medical Center 15:20-15:25 Break Hall A 15:25-16:10 Experts Session: Small molecules for ulcerative colitis – learn from the past anticipate for the future (Sponsored by BMS) TBA

Wednesday, January 27 10:30-11:00 – Business meeting of the Israeli Society of Gastroenterology and Liver Diseases Hall A Hall B 11:00-12:15 Session 6: Moderate-severe uncomplicated (also complicated) Crohn's 11:00-12:15 Session 7: Malignancies disease that you see in your everyday clinic Chairs: (Supported by Janssen) Naim Abu-Freha; Chairs: Zohar Levi Iris Dotan; Dan Turner 11:00-11:15 Moderate-severe uncomplicated Crohn's disease - challenges and 11:00-11:10 The impact of COVID-19 on screening for CRC in Europe and the US therapies Nathan Gluck Iris Dotan GI Malignancy Unit, Department of Gastroenterology, Sackler School of Rabin Medical Center Medicine, Tel Aviv University 11:15-11:30 The approach to newly diagnosed Crohn’s disease: what every clinician 11:10-11:20 What every gastroenterologist should know about the new Israeli guidelines should know in 2021 concerning Lynch Syndrome David Rubin Zohar Levi University of Chicago, Illinois, USA Rabin Medical Center 11:30-11:45 Penetrating disease? The surgeon can wait! Sometimes 11:20-11:30 New non-invasive methods for early detection of CRC Dan Turner Elez Vainer Shaare Zedek Medical Center, The Hebrew University of Hadassah-Hebrew University Medical Center 11:45-12:00 Q&A panel 11:30-11:37 GENETIC TESTING FOR ASSESSMENT OF LYNCH SYNDROME IN YOUNG PATIENTS WITH POLYPS Ido Laish1;Yael Goldberg2; Eitan Friedman3; Lior Katz4; Zohar Levi5; Uri Kopylov1; Dan Feldman6; Gili Reznick Levi7; Elizabeth Half8 1Gastroenterology Institute, Chaim Sheba Medical Center, 2Recanati Genetics Institute, Beilinson Hospital, Rabin Medical Center, 3Susanne Levy Gertner Oncogenetics Unit, The Danek Gertner Institute of Human Genetics, Chaim Sheba Medical Center, 4Department of Gastroenterology and Hepatology, , 5Gastroenterology Institute, Beilinson Hospital, Rabin Medical Center, 6Gastroenterology Institute, Meir Medical Center, 7Genetics Institute, Rambam Health Care Campus, 8Gastroenterology Institute, Rambam Health Care Campus 12:00-12:07 IMMUNE FUNCTION IN NEWBORNS OF FEMALES WOITH GESTATIONAL 11:37-11:57 BRCA and CRC ANTI-TNFα MEDICATION THERAPY FOR INFLAMMATORY BOWEL Elizabeth Half DISEASES Gastroenterology Department, Rambam Health Care Campus; Batia Weiss1,2; Shomron Ben-Horin3; Atar Lev4; Efrat Broide5; Miri Ido Laish Yavzori6; Adi Lahat3; Uri Kopylov3; Orit Picard3; Rami Eliakim3; Yulia Ron6; Meir Medical Center Irit Avni-Biron7; Anat Yerushalmi-Feler8; Amit Assa9; Raz Somech10,11; Ariella Bar-Gil Shitrit12 1Division of Pediatric Gastroenterology and Nutrition, Safra Children's Hospital, Tel Hashomer, 2Sackler Faculty of Medicine, Tel-Aviv University, 3Institute of Gastroenterology, Chaim Sheba Medical Center, 4Pediatric Immunology Laboratory, Chaim Sheba Medical Center,

5Division of Pediatric Gastroenterology, Assaf-Harofe Medical Center, 6Institute of Gastroenterology, Souraski Medical Center, 7Division of Gastroenterology, Rabin Medical Center, 8Division of Pediatric Gastroenterology, Dana Duek Children's Hospital, Souraski Medical Center, 9Institute of Pediatric Gastroenterology, Hepatology and Nutrition, Schneider Children's Hospital, 10Department of Pediatrics A, Edmond and Lily Safra Children, Hospital, Tel-Hashomer, 11Pediatric Immunology Laboratory, Chaim Sheba Medical Center, 12IBD MOM Unit, Digestive Diseases Institute, Shaare Zedek Medical Center 12:07-12:15 INCIDENTALLY DIAGNOSED ASYMPTOMATIC CROHN'S DISEASE: LONG- 11:57-12:05 INCREASED PREVALENCE OF COLORECTAL NEOPLASIA IN PATIENTS WITH IPMN: TERM CLINICAL OUTCOMES OF UNTREATED PATIENTS FACT OR FICTION? Ana Grinman; Bella Ungar; Gal Ben Haim; Adi Lahat; Uri Kopylov; Rami Dana Zelnik Yovel1; Lior Bear2; Tomer Ziv Baran2; Fadi Younis2,3; Erez Scapa3,2; Eliakim; Shomron Ben-Horin Mati Shnell2,3; Iddo Bar-Yishay2,3; Nir Bar3,2; Erwin Santo2,3; Oren Shibolet2,3; Sheba Medical Center Adam Phillips2,3; Dana Ben-Ami Shor2,3 1Shamir (Assaf Harofeh) Medical Center, 2Sackler Faculty of Medicine, Tel Aviv University, 3Department of Gastroenterology, Tel-Aviv Sourasky Medical Center 12:05-12:15 Live Q&A 12:15-12:30 Break Hall A Hall B 12:30-13:45 Session 8: Microbiome 12:30-13:45 Session 9: Nutrition Chairs: Chairs: Lev Lichtenstein, Assuta Medical Center; Liat Deutch, Sourasky Medical Center, Ichilov Hospital; Yehuda Ringel, Meir Medical Center Tal Engel, Chaim Sheba Medical Center, Sackler School of Medicine 12:30-12:50 Identification and Characterization of a Novel Gut Antimicrobial Peptide 12:30-12:45 Big data: Why is protein important in the critically ill COVID-19 patient? that Maintains Fungal Commensalism (Supported by Neopharm) Eugene Chang Pierre Singer Microbiome Medicine Program, University of Chicago, Illinois, USA Rabin Medical Center 12:50-13:10 Effects of Diet-Modulated Autologous Fecal Microbiota Transplantation 12:45-13:00 Endomicroscopic detection of atypical food allergy in patients with irritable on Weight Regain bowel syndrome – a new diagnostic era? Ehud Rinott Ralf Kiesslich Ben-Gurion University of the Negev Department of Gastroenterology, Helios HSK Wiesbaden, Germany 13:10-13:30 Is it time for H. pylori screening for all? 13:00-13:07 Crohn’s Disease Exclusion Diet Induces and Maintains Remission in Adults with Steven Moss Mild to Moderate Crohn's disease: a randomized controlled trial (CDED-AD trial) Department of Gastroenterology, Brown University, Providence, Rhode H. Yanai1,2; A. Levine2,3; R. Sigall Boneh2,4; A. Hirsch2,5; U. Kopylov2,6; H. Island, USA Banai Eran1,2; I. Goren1,2; H. Leibovitzh1,2; J. Wardi7; L. Abramas2,4; N. Fliss-Isakov2,5; E. Zitan8; T. Pfeffer Gik1,2; I. Dotan1,2; N. Maharshak 2,5 1IBD center, Division of Gastroenterology, Rabin Medical Center, 2Sackler Faculty of Medicine, Tel Aviv University, 3Paediatric Gastroenterology Unit, Wolfson Medical Center, 4PIBD Research Center, Wolfson Medical Center, , 5Department of Gastroenterology and Hepatology, Tel Aviv Sourasky Medical Center, 6Department of Gastroenterology, Sheba Medical Center, 7Gastroenterology Institute, Wolfson Medical Center, Holon, 8Gastroenterology Institute, Haemek Medical Center

13:30-13:37 ARTIFICIAL INTELLIGENCE SUCCESSFULLY IDENTIFIES SUBJECTS WHO 13:07-13:27 Diagnosis of PEI and the role of the PEI-Q ARE AT HIGH RISK FOR COLORECTAL CANCER AND WILL NOT SHOW UP (Supported by Abbott) FOR COLONOSCOPY WITHIN 6 MONTHS FOLLOWING A POSITIVE FECAL J. Enrique Dominguez-Munoz OCCULT BLOOD TEST (FOBT) Department of Gastroenterology and Hepatology, University Hospital Tom Konikoff1; Zohar Levy1,2; Iris Dotan1,2; Arnon Cohen3,4; Doron of Santiago de Compostela, Spain Caomanesther4; Hagit Perry5 1Division of Gastroenterology, Rabin Medical Center, 2Sackler Faculty of Medicine, Tel-Aviv University, 3Siaal Research Center for Family Medicine and Primary Care, Faculty of Health Sciences, Ben-Gurion University of the Negev, 4Department of Quality Measurements and Research, Chief Physician’s Office, , Tel Aviv, 5Department of Information Systems, Arison School of Business, Interdisciplinary Center, 13:37-13:45 THE INFLAMMATORY BOWEL DISEASE DISK APPLICATION: A PLATFORM 13:27-13:35 CORRELATION BETWEEN TONGUE TOPOGRAPHY AND GASTROINTESTINAL TO ASSESS PATIENTS PRIORITIES AND EXPECTATIONS FROM PATHOLOGY: MACHINE LEARNING, PILOT STUDY TREATMENT Igor Uchitel; Elad Schiff; Andrawus Beany; Tova Rainis Verd Richter1; Timna Naftali2; Amir Mari3; Tawfik Khoury4; Efrat Broide1 Technion 1Shamir Medical Center (Assaf Harofeh), 2Meir Medical Center, 3Nazareth Hospital, 4Galilee Medical Center 13:35-13:45 Live Q&A 13:45-14:00 Break Hall A 14:00-15:35 Session 10: Closing Plenary Session Chairs: Lior Katz; Michal Openhaim 14:00-14:20 Human organoid models for GI diseases Hans Clevers Hubrect Institute for Developmental Biology and Stem Cell Research (KNAW), The Netherlands 14:20-14:45 Physicial examination panel discussion Panel: Efrat Broide, Shamir Medical Center Lior Katz, Hadassah-Hebrew University Medical Center Nimrod Kimchi, Bat-Yamon Medical Center Reut Lutsky, Clalit Health Services Michal Openhaim, Meir Medical Center Doron Schwartz, Soroka University Medical Center 14:45-15:25 A lobby for the public - LIVE Linor Deutsch Co-founder & CEO Lobby99 15:25-15:35 Outstanding Abstracts and Committee Summary Naim Abu-Freha Lior Katz