www.iscort.org.il

Scientific Program

08.01.2019 - 12.01.2019, ,

The Annual Meeting of The Israeli Society for Clinical Oncology and Radiation Therapy ISCORT wishes to express its gratitude to the following companies הוועדה המארגנת for their support of the 19th ISCORT Annual Meeting: Organizing Committee ISCORT 19 נשיא הכנס: :President פרופ׳ סלומון שטמר Platinum Sponsor Salomon M. Stemmer, MD Roche מזכירת הכנס: :Secretory ד״ר ולריה סמניסטי Gold Sponsor Valeria Semenysty, MD יו"ר הרדיותרפיה: :BMS Radiation Oncology Co-Chair פרופ׳ בן קורן MSD Ben W. Corn, MD

הוועדה המדעית Silver Sponsor Scientific Committee ISCORT 19 Astellas יו"ר: פרופ' מיכל לוטם Astrazeneca Chairman: Michal Lotem, MD ד״ר אהרון אלון Boehringer Ingelheim Aaron Allen, MD ד״ר נועם אסנה Eli Lilly Noam Asna, MD ד״ר יאיר בר ISI Jair Bar, MD PhD ד״ר יהונתן כהן Novartis Yonathan Cohen, MD PhD פרופ׳ בן קורן Pfizer Ben W. Corn, MD ד״ר אלה עברון Rafa Ella Evron, MD ד״ר דניאלה כץ Daniela Katz, MD פרופ׳ גל מרקל Bronze Sponsor Gal Markel, MD PhD ד״ר אינה אוספובט AbbVie Inna Ospovat, MD ד״ר אביבית פאר Assuta Avivit Peer, MD ד״ר רות פרץ Bayer Ruth Perets, MD PhD Bolpharma ד״ר רפאל פפר Raphael Pfeffer, MD Dexcel Pharma ד״ר קרן רובינוב Keren Rouvinov, MD Isotopia ד״ר יקטרינה שולמן Katerina Shulman, MD Medison ד״ר אמיר זוננבליק Merck Amir Sonnenblick, MD ד״ר מרק ויגודה Nanostring Marc Wygoda, MD ד״ר אלונה זר Neopharm Alona Zer, MD ד״ר אביעד זיק Oncotest-Teva Aviad Zik, MD Perrigo החברה המארגנת Sanofi Organizing Company א.מ. כנסים בע"מ .Takeda I.M. Knasim Ltd חברים נכבדים, ,Dear friends and colleagues ברוכים הבאים לכנס השנתי של האיגוד הישראלי לאונקולוגיה קלינית Welcome to the 19th annual meeting of the Israel Society for Clinical ורדיותרפיה )ISCORT 19th( המתקיים באילת ב- 12-8 בינואר Oncology and Radiotherapy (ISCORT) to be held in Eilat on January 8-12, .2019 הכנס השנתי של ISCORT מארח את מרבית הצוותים המעורבים ועוסקים .2019 בטיפול ובמחקר במחלות הסרטן. כולנו עמלים יומם וליל במטרה לטייב את .The ISCORT annual meeting hosts the majority of Israeli teams in the field הטיפול על כל מרכיביו, שיפור בהישרדות והקטנת תופעות הלוואי, במטרה ,All of us are dedicated to the treatment of cancer patients, enhancing care להאריך את החיים ולשפר את איכות החיים של החולה, משפחתו והחברה improving outcome and reducing toxicity. We strive to improve the quality כולה. במקביל אנו עמלים על הוראה נטולת הטיות והנגשת הטיפול המיטבי of life for the patient, family members and society. We seek to promote לכל תושבי מדינת ישראל. unbiased education and improve access to optimal and affordable cancer בכנס שאירגנו לשנה זו תועלנה מספר סוגיות בנוגע למורכבות הטיפול בחולה .care במאה הThis year’s program emphasizes the complexity of cancer care in the 21st .21- בשנים האחרונות אנו חווים התפוצצות מידע עם גילוי יותר תרופות ״מוכוונות .century מטרה״, הפעלת המערכת החיסונית על יתרונותיה וחסרונותיה, ונסיון כן During the last years we have witnessed the rapid unfolding of cancer להקטנת תחלואה. חדשנות מביאה לשינוי תפיסה לגבי טיפולים מוכווני מטרה research, targeted therapy, as well as the advantages and limitations of the ולא מוכווני האיבר שבו נוצר הגידול. התובנות החדשות, בין השאר של גופים powerful immune system. Innovations in most areas of treatment have led to an agnostic approach with faster and more comprehensive drug approval רגולטורים, הביאו גם לקיצור בזמנים להבאת טכנולוגיות חדשות לחולים. by regulatory agencies. אנו חסרים עדיין תובנות רחבות יותר לגבי יחסי גומלין בין מחלה לחולה, בין גוף We are still on a quest for the ideal treatment, tailored to the specific human לנפש, מגדר ומגזר, התנהגות ואמונה. חדשנות ואינטרגרציה עשויים לשפר את being with his/her unique physiology, psychology, ethnicity, behavior and הטיפול בחולים שלנו. הרפואה והבריאות חשובים ביותר בחיי הפרט והחברה. belief. Novelty and integration will surely bring our patients to the best מכאן חובתינו להתיחס גם למרכיבים כלכליים של הטיפול. על כן יכלול הכנס possible outcome. Yet all novel approaches must be placed in a framework השנה מושבים קצרים בנושא של ״ערך הטיפול בסרטן״ מנקודת מבט כלכלית. of value to the individual patient as well as society. Therefore, we will have פתחנו מושבים של ״פגוש את המומחה״ המיועדים למתמחים ולמומחים .short sessions that will provide such context צעירים, שבהם יוכלו לדון במקרים בעייתיים עם האורחים הבינלאומיים ,For the residents and young faculty we launched a new format for ISCORT שמגיעים לכנס. Meet the Professor”, where participants are encouraged to present“ אנו מודים לכל העושים במלאכה להצלחת הכנס, ולחברי הוועדה המדעית, על challenging cases or to pose professional dilemmas to our distinguished עבודתם לבחירת מיטב התקצירים שיוצגו בכנס. .guests לסיום נזכיר, היות והכנס מסונף ל-ESMO, כנס בינלאומי, כל ההרצאות We thank all members who participated in the organization of the meeting והמושבים יתנהלו בשפה האנגלית. and scientific committee members for selecting the best abstracts to be shared by us. מאחלים לכולנו כנס פורה, מוצלח ומהנה, Looking forward to a great conference,

שלום, ,Shalom פרופ׳ סלומון שטמר פרופ׳ מיכל לוטם Salomon M Stemmer, MD Michal Lotem, MD נשיא יו״ר ועדה מדעית President Head of Scientific Committee פרופ׳ בן קורן ד״ר ולריה סמניסטי Ben W. Corn, MD Valerie Semenisty, MD יו"ר הרדיותרפיה מזכירה Radiation Oncology Co-Chair Secretory 18:10-18:50 Keynote Lecture Tuesday, January 8, 2019 Moderator: Gil Bar-Sela, MD Haemek Medical Center, , Israel 17:00–19:30 Opening Session Moving from precision medicine to next Moderator: Valeria Semenisty, MD generation healthcare Rambam Medical Center , Israel Joel Dudley, PhD 17:00-17:20 Welcome Associate Professor of Genetics and Genomic Salomon M. Stemmer, MD Sciences Davidoff Center, , Petach Director of the Institute for Next Generation Tikva, Israel Healthcare Mount Sinai Endowed Professor of Biomedical Wilmush Mermershtain, MD Data Science ISCORT Icahn School of Medicine at Mount Sinai 17:20-17:30 Resident Recognition Award Executive Vice President for Precision Health Mrs. Miri Ziv, CEO Mount Sinai Health System Israel Cancer Association, Givatayim, Israel New York, USA Supported by ISCORT and MSD 17:30-18:10 Best ISCORT Abstract Awards 18:50-19:30 Keynote Lecture Moderator: Michal Lotem, MD Moderator: Nir Peled, MD PhD , Israel , Beer Sheva, Israel Neoadjuvant pembrolizumab (Pembro) for early Clinical trials, personalized medicine and stage non-small cell lung cancer (NSCLC) – relationships with pharma: Time for reflection? initial report of a phase I study, MK3475-223 Ian Tanock, MD Jair Bar, MD PhD Emeritus professor of Medical Oncology and , Ramat-Gan, Israel Medical Biophysics Prophylactic irradiation to the contralateral Princess Margaret Cancer Centre and university of breast for BRCA mutation carriers with early Toronto, Canada mammary cancer Supported by ISCORT Ella Evron, MD , , Israel 19:30 Dinner A functional variant of the estrogen receptor: A potential novel driver of pancreatic cancer Ido Wolf, MD Sourasky Medical Center, Tel-Aviv, Israel Discussion and perspectives Michal Lotem, MD Hadassah Medical Center, Jerusalem, Israel Understanding the pathway in prostate cancer, Wednesday, January 9, 2019 present and future Johann de-Bono, MD 07:30-08:15 Meet the Professor The Institute of Cancer Research and The Royal Lung Cancer Marsden NHS Foundation Trust, London, England Tarshish B Hall Supported by Astellas and Janssen Moderators: Mor Moshkovich, MD 09:00-09:25 Sponsored Lecture Rambam Medical Center, Haifa, Israel Moderators: Victoria Neiman, MD Abed Agbarya, MD Davidoff Center, Rabin Medical Center , Haifa, Israel Petach Tikva, Israel Francis Shepherd, MD Keren Rouvinov, MD Department of Medicine at the University of Soroka Medical Center, Beer Sheva, Israel Toronto, Canada 2019 NHB - New treatment paradigm in RCC Supported by MSD Daniel Keizman, MD Prostate Cancer Meir Medical Center, , Israel Tarshish A Hall Supported by BMS Moderators: Noa Shani Shrem, MD 09:25-09:35 Value of Cancer Care Soroka Medical Center, Beer Sheva, Israel Moderator: Raya Leibowits, MD PhD David Sarid, MD ISCORT Basket Committee Sourasky Medical Center, Tel-Aviv, Israel Daniel Goldstein, MD Johann de-Bono, MD Davidoff Center, Rabin Medical Center The Institute of Cancer Research and The Royal Petach Tikva, Israel Marsden NHS Foundation Trust, London, England 09:35-10:15 Tumor Board: Urological Malignancies Supported by ASTELLAS Moderator: Avishay Sella, MD Genito-Urinary Malignancies – General Session Shamir (Asaf Harofe) Medical Center, , Israel 08:20-09:00 Keynote Lecture Panel: Johann de-Bono, MD Moderators: Eliezer Rosenbaum, MD The Institute of Cancer Research and The Royal Davidoff Center, Rabin Medical Center Marsden NHS Foundation Trust, London, England Petach Tikva, Israel Wilmush Mermershtein, MD Avivit Peer, MD Soroka Medical Center, Beer Sheva, Israel Rambam Medical Center, Haifa, Israel Raanan Berger, MD PhD Sheba Medical Center, Ramat-Gan, Israel Avivit Peer, MD Preliminary results from microbiome-based phase Rambam Medical Center, Haifa, Israel I clinical trial - fecal microbiota transplantation Eliezer Rosenbaum, MD in metastatic melanoma patients who failed Davidoff Center, Rabin Medical Center immunotherapy (NCT03353402) Petach Tikva, Israel Gal Markel, MD PhD Sheba Medical Center, Tel Hashomer, Israel 10:15-10:30 Coffee Break 11:10-11:30 Sponsored Lecture 10:30-11:10 Original Abstracts: GU and Melanoma Moderator: Ronen Brenner, MD Moderators: Maya Kolin, MD , Bat-Yam, Israel Rambam Medical Center, Haifa, Israel MORPEHEUS: Novel clinical trial design for Yonathan Cohen, MD PhD immunotherapy combinations Hadassah Medical Center, Jerusalem, Israel Julie Maltzman, MD Genomic analysis of urothelial cancer and Group Medical Director associations with treatment choice and outcome – Genentech a Member of The Roche Group, CA, USA collaborative research from the Israeli GU Supported by Roche oncology group 11:30-12:10 Tumor Board: Precision Oncology Raya Leibowitz MD PhD Sheba Medical Center, Ramat-Gan, Israel Moderator: Tamar Peretz, MD Hadassah Medical Center, Jerusalem, Israel Short term androgen deprivation therapy with/ without pelvic lymph node treatment added to Panel: Dov Hershkovitz, MD prostate bed only salvage radiotherapy: RTOG 0534 Sourasky Medical Center, Tel-Aviv, Israel Aron Allen, MD Nir Peled, MD PhD Davidoff Center, Rabin Medical Center Soroka Medical Center, Beer Sheva, Israel Petach Tikva, Israel Raanan Berger, MD PhD Ipilimumab-Nivolumab combination therapy Sheba Medical Center, Ramat-Gan, Israel in metastatic melanoma patients who have Eitan Rubin, PhD Senior Researcher progressed on previous anti PD-1 therapy Ben Gurion University, Beer Sheva, Israel Guy Ben-Betzalel, MD Sheba Medical Center, Ramat-Gan, Israel Doron Lipson, PHD VP Research & Early Development Brain derived melanoma cells suppress expression Foundation Medicine Inc., Cambridge, USA of key transcripts in tumor infiltrating lymphocytes Supported by Roche as compared with melanoma from visceral metastases 12:10-13:00 Lunch Jonathan Cohen, MD PhD Hadassah Medical Center, Jerusalem, Israel Lung Cancer - General Session The association between proton pump inhibitors 13:00-13:40 Keynote Lecture use and lung cancer risk: A nested case-control study Moderator: Alona Zer, MD Hadas Dresler, MD Davidoff Center, Rabin Medical Center Meir Medical Center, Kfar Saba, Israel Petach Tikva, Israel Osimertinib for patients with EGFR-positive Understanding the pathway in lung cancer advanced non-small cell lung cancer and Frances Shepherd, MD asymptomatic brain metastasis: preliminary Department of Medicine at the University of analysis of an open label two arm phase II study Toronto, Canada Nir Peled, MD PhD Supported by MSD Soroka Medical Center, Beer Sheva, Israel 13:40-14:05 Sponsored Lecture A single MAPK/Erk phosphorylation site dictates Moderator: Yulia Dudnik, MD distinct functions of highly homologous co- Soroka Medical Center, Beer Sheva, Israel repressors Stage III non small cell lung cancer, new Hovav Nechushtan, MD PhD paradigm Hadassah Medical Center, Jerusalem, Israel Scott J. Antonia, MD PhD EF hand domain family member D2 is required Thoracic Oncology Department, H.Lee Moffitt for T cell cytotoxicity Cancer Center and Research Institute, Tampa Amir Onn, MD Florida , USA Sheba Medical Center, Ramat-Gan, Israel Supported by Astra Zeneca 15:05-15:45 Tumor Board: Lung Malignancies 14:05-14:25 Sponsored Lecture Moderator: Jair Bar, MD PhD Moderator: Hovav Nechushtan, MD PhD Sheba Medical Center, Ramat-Gan,Israel Hadassah Medical Center, Jerusalem, Israel Panel: Maya Gottfried, MD Next generation targeted therapies: Sequencing Meir Medical Center, Kfar Saba, Israel challenges or best drug first? Damian Urban, MD Maya Gottfried, MD Sheba Medical Center, Ramat-Gan Israel Meir Medical Center, Kfar Saba, Israel Supported by Astra Zeneca and Takeda Frances Shepherd, MD Department of Medicine, Toronto University 14:25-15:05 Original Abstracts: Lung and Basic Science Canada Moderators: Elizabeth Dudnik, MD Uzi Izhar, MD Davidoff Center, Rabin Medical Center Hadassah Medical Center, Jerusalem, Israel Petach Tikva, Israel Raphael Pfeffer, MD Mira Wollner, MD , Tel-Aviv, Israel Rambam Medical Center, Haifa, Israel Supported by BI 15:45-16:00 Coffee Break 17:05-17:45 Tumor Board: Brain Metastasis 16:00-16:25 Sponsored Lecture Moderators: Shlomit Yust, MD Moderator: Noam Asna, MD Davidoff Center, Rabin Medical Center , Ashquelon, Israel Petach Tikva, Israel The evolving treatment landscape in SCLC Dror Limon, MD Barlessi Fabrice, MD PhD Sourasky Medical Center, Tel-Aviv, Israel Professor of Medicine, University of Aix Marseille Panel: Mor Moskovitz, MD and head of the Multidisciplinary Oncology and Rambam Medical Center, Haifa, Israel Therapeutic Innovations Department at Assistance Yosef Laviv, MD Publique Hôpitaux de Marseille, France Rabin Medical Center, Petach Tikva, Israel Supported by Roche Orit Kaidar-Person, MD 16:25-16:35 Value of Cancer Care Rambam Medical Center, Haifa, Israel Moderator: Katerina Shulman, MD 19:00 Dinner ISCORT Basket Committee Daniel Goldstein, MD Davidoff Center, Rabin Medical Center Petach Tikva, Israel 16:35-17:05 Keynote Lecture Moderator: Ben W. Corn Shaare Zedek Medical Center, Jerusalem, Israel Current thinking in the design of immuno- oncology and radiotherapy trials Adam P. Dicker, MD FASTRO Professor & Chair, Department of Radiation Oncology Director, Scholarly Inquiry Program in Digital Health & Data Science, Sidney Kimmel Medical College and Cancer Center, Philadelphia, USA Supported by ISCORT Ian Tannock, MD Thursday, January 10, 2019 Emeritus professor of Medical Oncology and Medical Biophysics, Princess Margaret Cancer 07:30-08:15 Meet the Professor Centre and University of Toronto, Canada Breast Malignancies 08:20-08:40 Case Reports and Discussion Tarshish A Hall Moderator and Moderators: Ayelet Shai, MD Discusssant: Ruth Perets, MD PhD , , Israel Rambam Medical Center, Haifa, Israel Bella Kaufman, MD Tumor lysis syndrome (TLS) in patient with Sheba Medical Center, Ramat-Gan, Israel metastatic non-small cell lung carcinoma Karen Gelmon, MD (mNSCLC) after a single dose of atezolizumab Professor of Medicine University of British Shira Sherman, MD Columbia, Medical Oncologist BCCancer, Canada Davidoff Center, Rabin Medical Center, Petach Supported by Astra Zeneca and MSD Tikva, Israel Radiotherapy Photofrin II as a radiosensitizer in cervix cancer Fiesta Hall Noam Asna, MD Moderators: Salem Billan, MD Barzilai Medical Center, , Israel Rambam Medical Center, Haifa, Israel Gastro Intestinal Malignancies – General Session Raphael Yechieli, MD 08:40-09:10 Keynote Lecture University of Miami and Sylvester Comprehensive Moderator: Nirit Yarom, MD Shamir (Asaf Harofe) Medical Cancer Center, USA Center, Tzrifin, Israel Adam Dicker, MD Understanding the pathway GI tumors Professor & Chair, Department of Radiation Dan Aderka, MD Sheba Medical Center Oncology Ramat-Gan, Israel Director, Scholarly Inquiry Program in Digital Health & Data Science 09:10-09:45 Keynote Lecture Sidney Kimmel Medical College and Cancer Moderator: Ephraim Idelevich, MD Kaplan Medical Center Center, Philadelphia, PA, USA Rehovot, Israel How to Read a Paper Present and future of systemic treatment of Tarshish B Hall hepatocellular carcinoma Moderators: Alberto Gabizon, MD Peter R. Galle, Univ-Prof Dr Shaare Zedek Medical Center, Jerusalem, Israel Chairman - First Department of Internal Medicine, University Medical Center Einav Gal Yam, MD PhD Mainz, Germany Sheba Medical Center, Ramat-Gan, Israel Supported by ISCORT 09:45-10:10 Tumor board - Advanced Hepatocellular Riad Haddad, MD Bnai Zion Medical Center Carcinoma Haifa, Israel Moderator: Ravit Geva, MD Supported by Eli Lilly Sourasky Medical Center, Tel-Aviv, Israel 11:35-12:20 Original Abstracts: GI Malignancies Panel: Peter R. Galle, Univ-Prof Dr Moderators: Sofia Man, MD Chairman - First Department of Internal Soroka Medical Center, Beer Sheva, Israel Medicine, University Medical Center Ofer Purim, MD Mainz, Germany Assuta Medical Center, , Israel Oren Shibolet, MD Benefit of oxaliplatin in stage III colon cancer Sourasky Medical Center, Tel-Aviv, Israel according to IDEA risk groups – analysis of Allan-Isaac Bloom, MD MOSAIC and C-07 trials Hadassah Medical Center, Jerusalem, Israel Ofer Margalit, MD Supported by Roche and ISCORT Sheba Medical Center, Ramat-Gan, Israel 10:10-10:40 Is There a Role for Surgery in Advanced GI Postoperative chemoradiotherapy in patients Malignancies? with locally advanced gastric cancer with Moderator: Ayala Hubert, MD Hadassah Medical Center poor pathologic response to neoadjuvant Jerusalem, Israel chemotherapy Ron Lewin, MD Pro: Izhak Avital, MD Soroka Medical Center Davidoff Center, Rabin Medical Center Beer Sheva, Israel Petach Tikva, Israel Con: Baruch Brenner, MD Davidoff Center Regorafenib treatment for patients with Rabin Medical Center, Petach Tikva, Israel hepatocellular carcinoma who progressed on 10:40-10:55 Coffee Break sorafenib - A cost-effectiveness analysis 10:55-11:35 Tumor board – Gastro Intestinal Malignancies Daniel Goldstein, MD Davidoff Center, Rabin Medical Center Moderator: Irit Ben Aharon, MD PhD Petach Tikva, Israel Rambam Medical Center, Haifa, Israel The role of genomic alterations as drivers of Panel: Talia Golan, MD liver-specific metastasis formation in pancreatic Sheba Medical Center, Ramat-Gan, Israel ductal adenocarcinoma (PDAC) cancer Sharon Peles, MD Ido Wolf, MD Sourasky Medical Center, Tel-Aviv, Israel Sourasky Medical Center, Tel-Aviv, Israel Eli Sapir, MD ATM as a biomarker for homologous Assuta Medical Center, Ashdod, Israel recombination repair deficiency in pancreatic ductal adenocarcinoma Tamar Beller, MD Sheba Medical Center, Ramat-Gan, Israel 12:20-13:00 Lunch 15:20-16:00 Tumor Board: Breast Cancer 13:00-14:00 Conference will reconvene at Tarshish Hall 1st Floor Moderator: Noa Efrat Ben-Baruch, MD Moderator: Salomon M. Stemmer, MD Davidoff Center Kaplan Medical Center, Rehovot, Israel Rabin Medical Center, Petach Tikva, Israel Panel: Rinat Yerushalmi, MD Innovation and collaboration Davidoff Center, Rabin Medical Center Petach Tikva, Israel Breast Cancer – General Session Tamar Peretz, MD 14:00-14:40 Keynote Lecture Hadassah Medical Center, Jerusalem, Israel Moderator: Tamar Safra, MD Bella Kaufman, MD Sourasky Medical Center, Tel-Aviv, Israel Sheba Medical Center, Ramat-Gan, Israel Finding our way through the pathways of breast Amir Sonnenblick, MD cancer Sourasky Medical Center, Tel-Aviv, Israel Karen A Gelmon, MD FRCPC Professor of Medicine University of British Dov Zippel, MD Columbia Sheba Medical Center, Ramat-Gan, Israel Medical Oncologist BCCancer, Canada Supported by Roche Chair UBC/BCC Research Ethics Board 16:00-16:15 Coffee Break Supported by Astra Zeneca and MSD 16:15-16:40 Sponsored Lecture 14:40-15:10 Sponsored Lecture Moderator: Ella Evron, MD Moderator: Ekarerina Senatsky, MD Kaplan Medical Center, Rehovot, Israel Lin Medical Center, Haifa, Israel Small steps, big impact – Rethinking outcome Update in treatment of advanced HR-positive measures in high risk breast cancer HER2-negative breast cancer including position Shani Paluch-Shimon, MD of CDK 4-6 Shaare Zedek Medical Center, Jerusalem, Israel Miguel Martin, MD PhD Supported by Roche Professor of Medicine, Head Medical Oncology 16:40-17:05 Sponsored Lecture Service, Hospital General Universitario Gregorio Marañón, Universidad Complutense, Madrid Moderator: Jamal Zidan, MD Spain Ziv Medical Center, , Israel Supported by Eli Lilly New horizons in clinical trials 15:10-15:20 Value of Cancer Care in Breast Cancer Chris Boshoff Senior Vice-President, Head Immuno-Oncology, Moderator: Rinat Yerushalmi, MD Early Development and Translational Oncology, ISCORT Basket Committee Pfizer Nathan Cherny, MD Supported by Pfizer Shaare Zedek Medical Center, Jerusalem, Israel 17:05-17:55 Original Abstracts: Breast Malignancies Friday, January 11, 2019 Moderators: Beatrice Uziely, MD Hadassah Medical Center, Jerusalem, Israel Immune Oncology Larissa Rivo, MD Assuta Hospital, Ashdod, Israel 08:30-10:05 Keynote lecture Partial compared to whole breast irradiation for Moderators: Michal Lotem, MD early stage breast cancer: A systematic review Hadassah Medical Center, Jerusalem, Israel and meta-analysis Gal Markel, MD PhD Yasmin Korzets Ceder, MD Sheba Medical Center, Ramat-Gan, Israel Davidoff Center, Rabin Medical Center Petach Tikva, Israel 08:30-08:35 Introduction Pregnancy after breast cancer diagnosis in Michal Lotem, MD BRCA1\2 mutation carriers Hadassah Medical Center, Jerusalem, Israel Albert Grinshpun, MD Hadassah Medical Center, Jerusalem, Israel 08:35-09:05 Immune checkpoint inhibitors in melanoma and The rate of the recurrent MSH6 mutations in other cancers - a review Ashkenazi Jewish breast cancer patients John Haanen Rinat Bernstein Molho, MD Professor of Translational Immunotherapy of Sourasky Medical Center, Tel-Aviv, Israel Cancer, Leiden University Medical Center The Netherlands Toxicity of extended adjuvant aromatase Supported by MSD inhibitors therapy in postmenopausal breast cancer patients: A systematic review and meta- 09:05-09:35 Tumor neo-antigens and T cell recognition analysis Yardena Samuels Hadar Goldvaser, MD Director, the EKARD Institute for Cancer Diagnosis Davidoff Center, Rabin Medical Center Research, Department of Molecular Cell Biology, Petach Tikva, Israel The Weizmann Institute of Science Rehovot, Israel Is prophylactic breast surgery indicated in BRCA mutation carriers following diagnosis of ovarian 09:35-10:05 Immunotherapy beyond melanoma cancer? Dmitriy Zamarin, MD Barliz Waissengrin, MD Gynecologic Medical Oncology, Sourasky Medical Center, Tel-Aviv, Israel Immunotherapeutics, Memorial Sloan-Kettering Cancer Center, New York, USA 19:00 Dinner Supported by ISCORT 10:05-10:45 Sponsored Lecture 11:50-12:30 Proposals and Follow-Up From Previous Years Moderator: Alexander Yaacobson, MD Grants Reports Soroka Medical Center, Beer Sheva, Israel Moderators: Valeria Semenisty, MD New approaches in the treatment of local and Rambam Medical Center, Haifa, Israel advanced melanoma Michal Lotem, MD Jacob Schachter, MD Hadassah Medical Center, Jerusalem, Israel Sheba Medical Center, Ramat-Gan, Israel Liquid biopsy of tumor microbiome Michal Lotem, MD Albert Grinshpun, MD Hadassah Medical Center, Jerusalem, Israel Hadassah Medical Center, Jerusalem, Israel Supported by BMS Interleukin-13 Receptor α1: A novel molecular 10:45-11:00 Coffee Break target to prevent radiation induced heart disease 11:00-11:30 Tumor Board: Melanoma Uri Amit, MD Sheba Medical Center, Ramat-Gan, Israel Moderator: Ronni Shapira, MD Sheba Medical Center, Ramat-Gan, Israel 12:30 Closing Remarks Panel: Gil Bar-Sela, MD 12:45 Lunch Haemek Medical Center, Afula, Israel 13:30-14:30 ISCORT Forum Meeting Ronnen Brenner, MD Wolfson Medical Center, , Israel Olga Vornicova, MD Rambam Medical Center, Haifa, Israel Dov Zipel, MD Sheba Medical Center, Ramat-Gan, Israel Supported by NOVARTIS 11:30-11:50 Sponsored Lecture Moderator: Raya Leibowitz, MD PhD Sheba Medical Center, Ramat-Gan, Israel Are we ready to offer a truly pan-tumor approach to therapy? Ido Wolf, MD Sourasky Medical Center, Tel-Aviv, Israel Supported by Roche Radiation Oncology Program 08:30-09:50 Clinical Abstracts Moderators: Eliahu Gez, MD Wednesday, January 9, 2019 Ziv Medical Center, Safed, Israel Salem Billan, MD 16:35-17:05 Keynote Lecture Rambam Medical Center, Haifa, Israel Lecture would be held in the main conference hall Adaptive IMRT planning improves pharyngeal Moderator: Ben W. Corn, MD constrictor sparing for oropharyngeal cancer Shaare Zedek, Medical Center, Jerusalem, Israel Dror Limon, MD Current thinking in the design of immuno- Sourasky Medical Center, Tel-Aviv, Israel oncology and radiotherapy trials CPAP improves the anatomy and dosimetry Adam P. Dicker, MD FASTRO of patients undergoing breath-hold motion Professor & Chair, Department of Radiation management for thoracic SBRT Oncology Igor Sadetskii, MD Director, Scholarly Inquiry Program in Digital Sheba Medical Center, Ramat-Gan, Israel Health & Data Science, Sidney Kimmel Medical Modern radiotherapy with or without androgen College and Cancer Center, Philadelphia, PA, USA deprivation therapy in intermediate-risk prostate Supported by ISCORT cancer Uri Amit, MD Sheba Medical Center, Ramat-Gan, Israel Thursday, January 10, 2019 Gastric fundus irradiation does not increase risk of postoperative anastomotic leakage in 07:30-08:15 Meet the Professor esophageal cancer Fiesta Hall Noga Kurman, MD Radiotherapy Davidoff Center, Rabin Medical Center Moderators: Salem Billan, MD Petach Tikva, Israel Rambam Medical Center, Haifa, Israel Adjuvant irradiation sandwiched between 6 Raphael Yechieli, MD cycles of carboplatin and paclitaxel for FIGO University of Miami and Sylvester Comprehensive stage III endometrial adenocarcinoma Cancer Center Florida, USA Nicola Nasser, MD PhD Montefiore Medical Center, Albert Einstein College Adam Dicker, MD of Medicine, New York, USA Professor & Chair, Department of Radiation Oncology The outcome of concomitant chemoradiotherapy Director, Scholarly Inquiry Program in Digital for the treatment of nasopharyngeal carcinoma Health & Data Science in the elderly population Sidney Kimmel Medical College and Cancer Orly Yariv, MD Center Davidoff Center, Rabin Medical Center Philadelphia, PA, USA Petach Tikva, Israel The effect of surgery to radiation interval on 12:05-12:30 Sponsored Lecture loco-regional recurrence and survival in patients The Elekta unity MR Linac – An overview and receiving post-mastectomy radiation treatments update of clinical experience Adaya Rosenthal, MD Joel W. Goldwein, MD Sheba Medical Center, Ramat-Gan, Israel Senior Vice President and Director, Medical Affairs 09:55-10:30 Physics Abstracts Elekta, Philadelphia, PA, USA Moderator: Rachel Bar Deroma, PhD Supported by Medtechnika Rambam Medical Center, Haifa, Israel 12:30-13:15 Lunch Development of X-ray lens for low energy 13:30-14:15 Clinical Debate: Oligometastatic Disease Turns 25 radiotherapy & radiosurgery. Moderator: Adam P. Dicker, MD FASTRO Dror Alezra, PhD Professor & Chair, Department of Radiation Sheba Medical Center, Ramat-Gan, Israel Oncology Do it, fuse it or lose it: On the benefits of PET CT Director, Scholarly Inquiry Program in Digital simulation Health & Data Science, Sidney Kimmel Medical Alona Rosenbaum, PhD College and Cancer Center, Philadelphia, PA, USA Ziv Medical Center, Safed, Israel Amichay Meirowitz, MD SRS spine plans: Comparing elements & eclipse Hadassah Medical Center, Jerusalem, Israel simulations to real measures Tomer Charas, MD Noam Weizman, MSc Rambam Medical Center, Haifa, Israel Hadassah Medical Center, Jerusalem, Israel 14:30-15:15 Revisiting the Conventional Wisdom in Non-Small 10:40-10:55 Coffee Break Cell Lung Cancer 10:55-11:20 Sponsored Lecture Moderator: Orit Person, MD Moderator: Raphael Pfeffer, MD Rambam Medical Center, Haifa, Israel Assuta Medical Center, Tel-Aviv, Israel Differential radiosensitivity between the lung Daphne Levin, PhD primary and the mediastinum Assuta Medical Center, Tel-Aviv, Israel Slava Soyfer, MD Real time image-guided RT: From 2D to 4D. Will Sourasky Medical Center, Tel-Aviv, Israel the MR Linac change practice? Technological advances in the treatment of lung Supported by Assuta Medical Center cancer 11:20-12:05 Sponsored Lecture Sarit Appel, MD Sheba Medical Center, Ramat-Gan, Israel Proton therapy: Benefits of IMPT Zelig Tochner, MD Integrating radiotherapy with novel biologic & Professor of Radiation Oncology, University of immunotherapeutic agents Pennsylvania, PA, USA Aaron Allen, MD Supported by VARIAN Davidoff Center, Rabin Medical Center Petach Tikva, Israel 15:30-16:00 Keynote Lecture Moderator: Aaron Allen, MD Introduction: Zvi Symon, MD Rabin Medical Center, Petach Tikva, Israel Sheba Medical Center, Ramat-Gan, Israel Panel: Rachamim Ben-Yosef MD Teen horror: The radiation oncologist meets the Rambam Medical Center, Haifa, Israel AYA population Yaacov Lawrence, MD Raphael Yechieli, MD Sheba Medical Center, Ramat-Gan, Israel Associate Professor of Radiation Oncology, Adam Dicker, MD University of Miami and Sylvester Comprehensive Professor & Chair, Department of Radiation Cancer Center, Miami, FL, USA Oncology 16:00-16:25 Coffee Break Director, Scholarly Inquiry Program in Digital 16:30-17:00 Sponsored Lecture Health & Data Science, Sidney Kimmel Medical College and Cancer Center, Philadelphia, PA, USA Moderator: Maoz Ben Ayun, PhD Chaim Sheba Medical Center, Ramat-Gan, Israel Shalom Kalinicki, MD Professor of Radiation Oncology, Albert Einstein ExacTrac Dynamic – A new dimension in surface College of Medicine tracking Chairman, Department of Radiation Oncology Luisa Schuetzenmeister, MSc Montefiore Medical Center New York, USA Product Manager ExacTrac BRAINLAB, Munich, Germany Supported by BRAINLAB 17:00-17:25 Sponsored Lecture Proton therapy: A perspective on the future Nicolas Denef, MSc Product Manager, IBA Louvain-La-Neuve, Belgium 17:30-18:15 Roundtable Discussion NRG & ISROG: Re-Kindling the Flames of Research?

This programm was printed with the support of Roche Pharmaceuticals (Israel) Ltd.