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Scientific Program www.iscort.org.il Scientific Program 08.01.2019 - 12.01.2019, Eilat, Israel The Annual Meeting of The Israeli Society for Clinical Oncology and Radiation Therapy ISCORT wishes to express its gratitude to the following companies הוועדה המארגנת for their support of the 19th ISCORT Annual Meeting: Organizing Committee ISCORT 19 נשיא הכנס: :President פרופ׳ סלומון שטמר Platinum Sponsor Salomon M. Stemmer, MD Roche מזכירת הכנס: :Secretory ד״ר ולריה סמניסטי Gold Sponsor Valeria Semenysty, MD יו"ר הרדיותרפיה: :BMS Radiation Oncology Co-Chair פרופ׳ בן קורן MSD Ben W. Corn, MD הוועדה המדעית Silver Sponsor Scientific Committee ISCORT 19 Astellas יו"ר: פרופ׳ מיכל לוטם Astrazeneca Chairman: Michal Lotem, MD ד"ר אהרון אלון Boehringer Ingelheim Aaron Allen, MD ד"ר נועם אסנה Eli Lilly Noam Asna, MD ד"ר יאיר בר ISI Jair Bar, MD PhD ד"ר יהונתן כהן Novartis Yonathan Cohen, MD PhD פרופ׳ בן קורן Pfizer Ben W. Corn, MD ד"ר אלה עברון Rafa Ella Evron, MD ד"ר דניאלה כץ Daniela Katz, MD פרופ׳ גל מרקל Bronze Sponsor Gal Markel, MD PhD ד"ר אינה אוספובט AbbVie Inna Ospovat, MD ד"ר אביבית פאר Assuta Avivit Peer, MD ד"ר רות פרץ Bayer Ruth Perets, MD PhD Bolpharma ד"ר רפאל פפר Raphael Pfeffer, MD Dexcel Pharma ד"ר קרן רובינוב Keren Rouvinov, MD Isotopia ד"ר יקטרינה שולמן Katerina Shulman, MD Medison ד"ר אמיר זוננבליק Merck Amir Sonnenblick, MD ד"ר מרק ויגודה Nanostring Marc Wygoda, MD ד"ר אלונה זר Neopharm Alona Zer, MD ד"ר אביעד זיק Oncotest-Teva Aviad Zik, MD Perrigo החברה המארגנת Sanofi Organizing Company א.מ. כנסים בע"מ .Takeda I.M. Knasim Ltd חברים נכבדים, ,Dear friends and colleagues ברוכים הבאים לכנס השנתי של האיגוד הישראלי לאונקולוגיה קלינית Welcome to the 19th annual meeting of the Israel Society for Clinical ורדיותרפיה )ISCORT 19th( המתקיים באילת ב- 12-8 בינואר Oncology and Radiotherapy )ISCORT( to be held in Eilat on January 8-12, .2019 הכנס השנתי של ISCORT מארח את מרבית הצוותים המעורבים ועוסקים .2019 בטיפול ובמחקר במחלות הסרטן. כולנו עמלים יומם וליל במטרה לטייב את .The ISCORT annual meeting hosts the majority of Israeli teams in the field הטיפול על כל מרכיביו, שיפור בהישרדות והקטנת תופעות הלוואי, במטרה ,All of us are dedicated to the treatment of cancer patients, enhancing care להאריך את החיים ולשפר את איכות החיים של החולה, משפחתו והחברה improving outcome and reducing toxicity. We strive to improve the quality כולה. במקביל אנו עמלים על הוראה נטולת הטיות והנגשת הטיפול המיטבי of life for the patient, family members and society. We seek to promote לכל תושבי מדינת ישראל. unbiased education and improve access to optimal and affordable cancer בכנס שאירגנו לשנה זו תועלנה מספר סוגיות בנוגע למורכבות הטיפול בחולה .care במאה הThis year’s program emphasizes the complexity of cancer care in the 21st .21- בשנים האחרונות אנו חווים התפוצצות מידע עם גילוי יותר תרופות "מוכוונות .century מטרה", הפעלת המערכת החיסונית על יתרונותיה וחסרונותיה, ונסיון כן During the last years we have witnessed the rapid unfolding of cancer להקטנת תחלואה. חדשנות מביאה לשינוי תפיסה לגבי טיפולים מוכווני מטרה research, targeted therapy, as well as the advantages and limitations of the ולא מוכווני האיבר שבו נוצר הגידול. התובנות החדשות, בין השאר של גופים powerful immune system. Innovations in most areas of treatment have led to an agnostic approach with faster and more comprehensive drug approval רגולטורים, הביאו גם לקיצור בזמנים להבאת טכנולוגיות חדשות לחולים. by regulatory agencies. אנו חסרים עדיין תובנות רחבות יותר לגבי יחסי גומלין בין מחלה לחולה, בין גוף We are still on a quest for the ideal treatment, tailored to the specific human לנפש, מגדר ומגזר, התנהגות ואמונה. חדשנות ואינטרגרציה עשויים לשפר את being with his/her unique physiology, psychology, ethnicity, behavior and הטיפול בחולים שלנו. הרפואה והבריאות חשובים ביותר בחיי הפרט והחברה. belief. Novelty and integration will surely bring our patients to the best מכאן חובתינו להתיחס גם למרכיבים כלכליים של הטיפול. על כן יכלול הכנס possible outcome. Yet all novel approaches must be placed in a framework השנה מושבים קצרים בנושא של "ערך הטיפול בסרטן" מנקודת מבט כלכלית. of value to the individual patient as well as society. Therefore, we will have פתחנו מושבים של "פגוש את המומחה" המיועדים למתמחים ולמומחים .short sessions that will provide such context צעירים, שבהם יוכלו לדון במקרים בעייתיים עם האורחים הבינלאומיים ,For the residents and young faculty we launched a new format for ISCORT שמגיעים לכנס. Meet the Professor”, where participants are encouraged to present“ אנו מודים לכל העושים במלאכה להצלחת הכנס, ולחברי הוועדה המדעית, על challenging cases or to pose professional dilemmas to our distinguished עבודתם לבחירת מיטב התקצירים שיוצגו בכנס. .guests לסיום נזכיר, היות והכנס מסונף ל-ESMO, כנס בינלאומי, כל ההרצאות We thank all members who participated in the organization of the meeting והמושבים יתנהלו בשפה האנגלית. and scientific committee members for selecting the best abstracts to be shared by us. מאחלים לכולנו כנס פורה, מוצלח ומהנה, Looking forward to a great conference, שלום, ,Shalom פרופ׳ סלומון שטמר פרופ׳ מיכל לוטם Salomon M Stemmer, MD Michal Lotem, MD נשיא יו"ר ועדה מדעית President Head of Scientific Committee פרופ׳ בן קורן ד"ר ולריה סמניסטי Ben W. Corn, MD Valerie Semenisty, MD יו"ר הרדיותרפיה מזכירה Radiation Oncology Co-Chair Secretory 18:10-18:50 Keynote Lecture Tuesday, January 8, 2019 Moderator: Gil Bar-Sela, MD Haemek Medical Center, Afula, Israel 17:00–19:30 Opening Session Moving from precision medicine to next Moderator: Valeria Semenisty, MD generation healthcare Rambam Medical Center Haifa, Israel Joel Dudley, PhD 17:00-17:20 Welcome Associate Professor of Genetics and Genomic Salomon M. Stemmer, MD Sciences Davidoff Center, Rabin Medical Center, Petach Director of the Institute for Next Generation Tikva, Israel Healthcare Mount Sinai Endowed Professor of Biomedical Wilmush Mermershtain, MD Data Science ISCORT Icahn School of Medicine at Mount Sinai 17:20-17:30 Resident Recognition Award Executive Vice President for Precision Health Mrs. Miri Ziv, CEO Mount Sinai Health System Israel Cancer Association, Givatayim, Israel New York, USA Supported by ISCORT and MSD 17:30-18:10 Best ISCORT Abstract Awards 18:50-19:30 Keynote Lecture Moderator: Michal Lotem, MD Hadassah Medical Center Moderator: Nir Peled, MD PhD Jerusalem, Israel Soroka Medical Center, Beer Sheva, Israel Neoadjuvant pembrolizumab (Pembro) for early Clinical trials, personalized medicine and stage non-small cell lung cancer (NSCLC) – relationships with pharma: Time for reflection? initial report of a phase I study, MK3475-223 Ian Tanock, MD Jair Bar, MD PhD Emeritus professor of Medical Oncology and Sheba Medical Center, Ramat-Gan, Israel Medical Biophysics Prophylactic irradiation to the contralateral Princess Margaret Cancer Centre and university of breast for BRCA mutation carriers with early Toronto, Canada mammary cancer Supported by ISCORT Ella Evron, MD Kaplan Medical Center, Rehovot, Israel 19:30 Dinner A functional variant of the estrogen receptor: A potential novel driver of pancreatic cancer Ido Wolf, MD Sourasky Medical Center, Tel-Aviv, Israel Discussion and perspectives Michal Lotem, MD Hadassah Medical Center, Jerusalem, Israel Understanding the pathway in prostate cancer, Wednesday, January 9, 2019 present and future Johann de-Bono, MD 07:30-08:15 Meet the Professor The Institute of Cancer Research and The Royal Lung Cancer Marsden NHS Foundation Trust, London, England Tarshish B Hall Supported by Astellas and Janssen Moderators: Mor Moshkovich, MD 09:00-09:25 Sponsored Lecture Rambam Medical Center, Haifa, Israel Moderators: Victoria Neiman, MD Abed Agbarya, MD Davidoff Center, Rabin Medical Center Bnai Zion Medical Center, Haifa, Israel Petach Tikva, Israel Francis Shepherd, MD Keren Rouvinov, MD Department of Medicine at the University of Soroka Medical Center, Beer Sheva, Israel Toronto, Canada 2019 NHB - New treatment paradigm in RCC Supported by MSD Daniel Keizman, MD Prostate Cancer Meir Medical Center, Kfar Saba, Israel Tarshish A Hall Supported by BMS Moderators: Noa Shani Shrem, MD 09:25-09:35 Value of Cancer Care Soroka Medical Center, Beer Sheva, Israel Moderator: Raya Leibowits, MD PhD David Sarid, MD ISCORT Basket Committee Sourasky Medical Center, Tel-Aviv, Israel Daniel Goldstein, MD Johann de-Bono, MD Davidoff Center, Rabin Medical Center The Institute of Cancer Research and The Royal Petach Tikva, Israel Marsden NHS Foundation Trust, London, England 09:35-10:15 Tumor Board: Urological Malignancies Supported by ASTELLAS Moderator: Avishay Sella, MD Genito-Urinary Malignancies – General Session Shamir )Asaf Harofe( Medical Center, Tzrifin, Israel 08:20-09:00 Keynote Lecture Panel: Johann de-Bono, MD Moderators: Eliezer Rosenbaum, MD The Institute of Cancer Research and The Royal Davidoff Center, Rabin Medical Center Marsden NHS Foundation Trust, London, England Petach Tikva, Israel Wilmush Mermershtein, MD Avivit Peer, MD Soroka Medical Center, Beer Sheva, Israel Rambam Medical Center, Haifa, Israel Raanan Berger, MD PhD Sheba Medical Center, Ramat-Gan, Israel Avivit Peer, MD Preliminary results from microbiome-based phase Rambam Medical Center, Haifa, Israel I clinical trial - fecal microbiota transplantation Eliezer Rosenbaum, MD in metastatic melanoma patients who failed Davidoff Center, Rabin Medical Center immunotherapy (NCT03353402) Petach Tikva, Israel Gal Markel, MD PhD Sheba Medical Center, Tel Hashomer, Israel 10:15-10:30 Coffee Break 11:10-11:30 Sponsored Lecture 10:30-11:10 Original Abstracts: GU and Melanoma Moderator: Ronen Brenner, MD Moderators: Maya Kolin, MD Wolfson Medical Center, Bat-Yam, Israel Rambam Medical
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