An online version of this diagram is available at BioCyc.org. Biosynthetic pathways are positioned in the left of the cytoplasm, degradative pathways on the right, and reactions not assigned to any pathway are in the far right of the cytoplasm. Transporters and membrane proteins are shown on the membrane. Periplasmic (where appropriate) and extracellular reactions and proteins may also be shown. Pathways are colored according to their cellular function. Gcf_000411195-HmpCyc: Delftia acidovorans CCUG 274B Cellular Overview Connections between pathways are omitted for legibility.

sn-glycerol a dicarboxylate a dicarboxylate an amino an amino an amino an amino an amino an amino an amino 3-phosphate O-acetyl-L-serine an amino an amino acid acid acid acid acid acid acid an aromatic an amino an amino an amino an amino an amino an amino an amino an amino an amino an amino cys sn-glycerol acid acid glutamate glutamate glutamate Fe 2+ amino acid acid acid acid acid acid acid predicted 3-phosphate acid acid acid acid enterobactin ABC predicted predicted predicted predicted predicted predicted predicted transporter ABC ABC ABC ABC ABC ABC ABC RS32735 RS04550 RS10535 RS13605 RS15475 RS15470 RS16910 RS30270 RS11330 RS26660 RS26655 RS18485 RS05155 RS21560 RS30425 RS15600 RS05020 RS11425 RS02945 RS07585 RS30175 RS02895 RS07555 RS09960 RS17430 RS02730 RS10335 RS10680 RS16050 RS22970 RS06675 RS08770 RS30075 RS04655 RS08420 RS10940 RS25135 RS22045 RS29235 RS08015 RS04605 RS08300 RS10155 RS28975 RS13905 RS13355 RS04600 RS03585 RS04625 RS21235 RS04635 RS08415 RS02475 RS16515 RS04050 RS12870 RS06670 RS02600 RS07500 of sn- RS10495 RS10685 RS13875 RS15075 RS05930 RS11390 RS21480 RS18520 transporter transporter transporter RS21660 transporter RS08435 RS26010 RS09940 RS09970 RS29930 RS29790 RS23695 transporter RS21990 RS22120 transporter transporter RS31260 RS21980 RS21985 RS05025 RS13375 glycerol 3- of an of an of an of an of an of an of an phosphate amino acid amino acid amino acid amino acid amino acid amino acid amino acid O-acetyl-L-serine an aromatic Fe 2+ cys sn-glycerol an amino an amino an amino an amino an amino an amino an amino an amino an amino an amino an amino an amino glutamate glutamate glutamate enterobactin amino acid 3-phosphate acid acid acid acid acid acid acid acid acid acid acid acid an amino an amino an amino an amino an amino sn-glycerol a dicarboxylate a dicarboxylate an amino an amino acid acid acid acid acid 3-phosphate acid acid

RS22565 RS13740 Cofactor, Prosthetic Group, Electron Carrier, and Vitamin Biosynthesis Secondary Metabolite Degradation Degradation/Utilization/ Assimilation - Other methylmalonate L-alanyl-γ-D- an [amino group carrier protein]- a [glutamine a 2-methoxy-6-all- 2-(1,2-epoxy-1,2- DNA combined a [protein]-L- O-acetyl-L- 2-oxoglutarate phosphoenol an [HPr]- a [glutamine- a ribonucleoside cob(II)yrinate a,c- Aminoacyl-tRNA Charging Fermentation mixed acid fermentation D-galacturonate degradation I acrylonitrile degradation I semialdehyde methanethiol UDP-N-acetyl- glutamyl-meso-2,6- C-terminal-γ-(L-glutamate 5- synthetase]-O trans-polyprenyl- dihydrophenyl) with exogenous β-isoaspartate met cob(II)yrinate a,c-diamide superpathway of tetrahydrofolate biosynthesis NAD phosphorylation and dephosphorylation superpathway of adenosylcobalamin salvage from cobinamide I ubiquinol-8 biosynthesis (prokaryotic) superpathay of heme b heme b biosynthesis thiamine salvage II 5-methylbenzimidazolyl adenosylcobamide superpathway of D-glucarate and D-galactarate degradation L-threitol degradation D-galactarate degradation II homoserine pyruvate L-histidine synthetase]- ATP diphosphate IMP diamide biosynthesis I methylmalonate- α-D-muramate diaminopimeloyl- semialdehyde-2-yl)-L-glutamate 2-oxoglutarate phosphoenolpyruvate- 4 -(5'-adenylyl) 1,4-benzoquinol acetyl-CoA DNA to form a protein-L-isoaspartate(D- biosynthesis II (late biosynthesis from glutamate II (anaerobic) O-acetylhomoserine N-acetyl-gamma-glutamyl- L-tyrosine bifunctional ribonucleoside- bifunctional glutamate RS27175 RS13745 (early cobalt insertion) biosynthesis from adenosylcobinamide-GDP aldehydo-D- D-glucarate degradation II semialdehyde UDP-N-acetylmuramate:L- dehydrogenase -L-tyrosine bifunctional [glutamate- bifunctional [glutamate- 2-(1,2-epoxy-1,2- aspartate) O- bifunctional cobalt incorporation) + all-trans- 4-amino-2-methyl-5- tRNA charging (thiol)-lyase: D-alanine -protein diphosphate reductase: recombinational N-acetyltransferase/ NAD phosphoenolpyruvate galacturonate acrylonitrile phosphate reductase: -ammonia ligase]- demethylmenaquinone dihydrophenyl)acetyl- Holliday junction metallophosphatase/ cob(II)inamide 4-hydroxybenzoate octaprenyl L-asparagine biosynthesis D-glucarate L-threitol D-galactarate dehydrogenase HMPREF9701_RS30875 alanyl-gamma-D- E1 component: phosphotransferase: -ammonia ligase]- junction methyltransferase: uroporphyrinogen-III uroporphyrinogen-III GTP glu uroporphyrinogen-III pyrimidinemethanol 5-methylbenzimidazole NaMN HMPREF9701_RS21535 methyltransferase/2- HMPREF9701_RS04470 CoA isomerase: resolvase RuvX: amino-acid III (tRNA-dependent) erythritol/L-threitol D-glucarate galactarate dehydratase: (CoA acylating): glutamyl- meso- HMPREF9701_RS26950 HMPREF9701_RS07310 adenylyl-L-tyrosine adenylyl-L-tyrosine HMPREF9701_RS31235 5'-nucleotidase: uroporphyrinogen-III 4-hydroxybenzoatediphosphate uroporphyrinogen hydroxymethylpyrimidine/ O-acetylhomoserine N-acetyl-gamma-glutamyl- methoxy-6-polyprenyl- HMPREF9701_RS04475 HMPREF9701_RS22570 HMPREF9701_RS04100 acetyltransferase ArgJ: uroporphyrinogen-III ATP:cob(I)alamin glutamate--tRNA ligase: arg phosphoenolpyruvate pyruvate kinase: dehydrogenase: glucarate dehydratase: HMPREF9701_RS08240 HMPREF9701_RS17050 diaminopimelate ligase: phosphorylase/[glutamate- phosphorylase/[glutamate- HMPREF9701_RS08690 C-methyltransferase: octaprenyltransferase: decarboxylase: phosphomethylpyrimidine nicotinate-nucleotide-- D-tagaturonate D-galactarate glucarate dehydratase: aminocarboxypropyltransferase/ UDP-N-acetylmuramoyl- alpha-ketoglutarate phosphoenolpyruvate- 1,4-benzoquinol ribonucleoside- protein-L-isoaspartate HMPREF9701_RS10945 RS17335 RS13750 C-methyltransferase: GTP cyclohydrolase alkaline phosphatase D: NAD(P) transhydrogenase: adenosyltransferase: HMPREF9701_RS13520 arginine--tRNA ligase: carboxylase: HMPREF9701_RS18170 HMPREF9701_RS05840 HMPREF9701_RS08250 5-dehydro-4- acrylamide HMPREF9701_RS04520 phosphate reductase: -ammonia-ligase] -ammonia-ligase] 2-(1,2-epoxy-1,2- crossover junction 5'-nucleotidase: HMPREF9701_RS15940 NAD kinase: HMPREF9701_RS12920 an L-glutamyl- HMPREF9701_RS22560 kinase: dimethylbenzimidazole asp HMPREF9701_RS08250 methylmalonate- cysteine synthase: γ dehydrogenase: -protein methylase UbiE: O-methyltransferase: HMPREF9701_RS15940 I FolE2: HMPREF9701_RS31255 HMPREF9701_RS07680 HMPREF9701_RS29775 3-octaprenyl-4- HMPREF9701_RS25705 an L-arginyl- Asn L-erythrulose deoxy-D-glucarate L-alanyl- -D- an [amino group carrierHMPREF9701_RS14295 protein]- adenylyltransferase: diphosphate reductase, dihydrophenyl)acetyl- endodeoxyribonuclease amino-acid N- precorrin-1 Glu aspartyl-tRNA HMPREF9701_RS09635 glucarate HMPREF9701_RS23470 adenylyltransferase: HMPREF9701_RS28440 HMPREF9701_RS08585 precorrin-1 HMPREF9701_RS11520 hydroxybenzoate [tRNA ] coproporphyrinogen III HMPREF9701_RS04140 phosphoribosyltransferase: Arg glucarate amidase: semialdehyde HMPREF9701_RS10345 glutamyl-meso-2,6- γ phosphotransferase: a 6-methoxy-3-methyl-HMPREF9701_RS11315 adenosylcobalamin- a protein L-β- acetyltransferase: HMPREF9701_RS16830 [+ 3 isozymes] HMPREF9701_RS07685 cob(I)yrinic acid a,c-diamide [tRNA ] synthetase: galactarate dehydratase: dehydratase: 5-dehydro-4- C-terminal- -(5-phospho- HMPREF9701_RS14195 a [glutamine HMPREF9701_RS14195 CoA isomerase: resolution ofRuvC: HMPREF9701_RS01415 Arg pyruvate dehydrogenase NADH CO succinyl-CoA HMPREF9701_RS01055 a [glutamine- inosine uroporphyrinogen-III a tRNA HMPREF9701_RS08240 dehydratase: gudD deoxyglucarate HMPREF9701_RS20375 acetate met diaminopimeloyl- L-glutamyl)-L-glutamate 2 an [HPr protein]- synthetase]-O 2-all-trans-polyprenyl- dependent: HMPREF9701_RS13255 recombinationalHMPREF9701_RS04580 isoaspartate HMPREF9701_RS05810 uroporphyrinogen-III GTP cyclohydrolase I: adenosyltransferase: glutamyl-tRNA reductase: oxygen-independent bifunctional HMPREF9701_RS11355 gudD ADP synthetase]- an L-aspartyl- D-altronate (CoA acylating): D-alanine π 4 1,4-benzoquinol HMPREF9701_RS24985 2-oxepin-2(3H)- α-methyl ester N-acetyl-L- C-methyltransferase: HMPREF9701_RS01330 coproporphyrinogen hydroxymethylpyrimidine 5-methylbenzimidazole oxaloacetate 5-dehydro-4- dehydratase: [+ 3 isozymes] N -phospho- pyruvate -(5'-adenylyl) a 2'- junction RS13785 RS14775 C-methyltransferase: HMPREF9701_RS11375 HMPREF9701_RS11245 [tRNA Asn ] HMPREF9701_RS12730 L-tyrosine ylideneacetyl-CoA methionine HMPREF9701_RS15940 7,8- [corrinoid kinase/ adenosylcobinamide-GDP L-erythrulose deoxy-D-glucarate HMPREF9701_RS08265 L-histidine -L-tyrosine formation of two HMPREF9701_RS15940 NADP + III oxidase: ribotide phosphate D-lactate dehydrogenase: altronate dehydratase: 5-dehydro-4-deoxy-D-glucarate deoxyribonucleoside (S)-4-amino-5- acrylate + NADH dihydroneopterin adenosyltranferase]- 2-octaprenylphenol HMPREF9701_RS01245 phosphomethylpyrimidine aspartyl-tRNA(Asn)/ HMPREF9701_RS26560 1-phosphate 5-dehydro-4- 2,5- H hydrogencarbonate propanoyl-CoA 5'-diphosphate intact strands precorrin-2 oxopentanoate 4-amino-2-methyl-5- malate dehydrogenase: HMPREF9701_RS16020 precorrin-2 3'-triphosphate cob(II)inamide kinase: glutamyl-tRNA (Gln) alpha-dehydro-beta-deoxy- deoxyglucarate dioxopentanoate H + RS29240 H + adenosylcobinamide- diphosphomethylpyrimidine cys HMPREF9701_RS20060 Aldehyde Degradation dihydroneopterin glutamate-1-semialdehyde- protoporphyrinogen IX HMPREF9701_RS26335 cysteine--tRNA ligase: amidotransferase subunit 2-dehydro-3- D-glucarate aldolase: dehydratase: precorrin-2 C(20)- GDP ribazoletransferase: biosynthesis acetyl-CoA formate (R)-lactate RS19290 triphosphate 2,1-aminomutase: A: HMPREF9701_RS04750 deoxy-D-gluconate HMPREF9701_RS29950 HMPREF9701_RS08265 a nascent peptidoglycan a DNA containing (R)-4'- 2-methylacetoacetyl- (1S,2R)-1- a cytosine 967 all trans-decaprenyl- 2-methoxy-6-all 6-methoxy-2-all- an organic HMPREF9701_RS08495 HMPREF9701_RS23425 an L-cysteinyl- D-erythrulose methylglyoxal degradation I keto- trans-aconitate acetyl-CoA NMN DMKH methyltransferase: HMPREF9701_RS04145 HMP-P (S)-malate γ phosphopantothenoyl- 2-methoxy-6- trans-heptaprenyl- trans-octaprenyl- 2 diphosphatase: 3-(all-trans AIR Cys with (L-alanyl- -D- tyr an apurinic/ CoA C-(indol-3- in 16S rRNA hydroperoxide [+ 2 isozymes] formate hydrogenlyase 2,5- phenylpyruvate ser + + HMPREF9701_RS06715 [corrinoid [tRNA ] citrate synthase: tartronate semialdehyde 4-phosphate lipid II (meso L-cysteine acetyl-CoA C- 1,4-benzoquinol 1,4-benzoquinol 1,4-benzoquinone trans-aconitate 2- acetyl-CoA C- alkylhydroperoxidase 5'-nucleotidase: H RS16520 H HMPREF9701_RS11365 -octaprenyl) Coα-[α-(5-methylbenzimidazolyl) phosphomethylpyrimidine Cys phosphate glutamyl-meso-2,6- aspartate/tyrosine/ apyrimidinic site yl)glycerol 16S rRNA bifunctional bifunctional bifunctional sirohydrochlorin adenosyltranferase]- 5-aminolevulinate a tRNA an L-asparaginyl- class II fumarate HMPREF9701_RS20025 complex: dioxopentanoate 2-oxoglutarate erythritol degradation II diaminopimelate endonuclease III: bifunctional bifunctional 7,8- benzene-1,2-diol hydroxymethylpyrimidine/ ]-Coβ-adenosylcobamide synthase ThiC: methylglyoxal diaminopimeloyl- acetyltransferase: 3-phosphate tryptophan synthase (cytosine(967)-C(5))- methyltransferase: acetyltransferase: domain protein: HMPREF9701_RS08585 demethylmenaquinone precorrin-3A cob(I)inamide [tRNA Asn ] hydratase: fumC acetyltransferase: HMPREF9701_RS12170 2-hydroxy-3- aromatic aminotransferase: HMPREF9701_RS01455 phosphopantothenoylcysteine demethylmenaquinone demethylmenaquinone demethylmenaquinone dihydroneopterin bifunctional 2-polyprenyl-6- protoporphyrin IX phosphomethylpyrimidine D-alanyl-D-alanine) monofunctionalcontaining) HMPREF9701_RS16650 subunit beta: methyltransferase RsmB: HMPREF9701_RS27025 HMPREF9701_RS16650 HMPREF9701_RS13095 bifunctional methyltransferase/2- RS26775 sirohydrochlorin ATP:cob(I)alamin 5'-phosphate HMPREF9701_RS15615 HMPREF9701_RS19395 KDGP oxopropionate reductase: lactoylglutathione lyase: HMPREF9701_RS28670 decarboxylase/ methyltransferase/2- methyltransferase/2- methyltransferase/2- 3'-phosphate porphobilinogen synthase: kinase: [+ 2 isozymes] citrate acetaldehyde erythritol biosynthetic peptidoglycan bifunctional DNA- cobaltochelatase: hydroxyphenol methylase/ HMP-P [+ 2 isozymes] CO H D-erythrose HMPREF9701_RS28330 pentapeptide acetyl-CoA C- HMPREF9701_RS03265 HMPREF9701_RS22640 methoxy-6-polyprenyl- methoxy-6-polyprenyl- methoxy-6-polyprenyl- trans-aconitate 2- acetyl-CoA C- alkyl hydroperoxide metallophosphatase/ methoxy-6-polyprenyl- H + RS06300 H + precorrin-3B synthase: adenosyltransferase: HMPREF9701_RS07455 ferrochelatase: HMPREF9701_RS04140 2 2 HMPREF9701_RS17835 erythritol/L-threitol aspartate/tyrosine/ formamidopyrimidine phosphopantothenate-- HMPREF9701_RS16410 flavin biosynthesis I (bacteria and plants) 3-demethylubiquinol 3-O- fumarate 2-dehydro-3- 4-phosphate (R)-S- transglycosylase: acetyltransferase: tryptophan synthase ribosomal RNA small 1,4-benzoquinol 1,4-benzoquinol methyltransferase: acetyltransferase: reductase: 5'-nucleotidase: 1,4-benzoquinol HMPREF9701_RS06725 HMPREF9701_RS29775 HMPREF9701_RS15335 glutamine--tRNA bifunctional aconitate alcohol dehydrogenase: 2-oxoglutarate dehydrogenase: aromatic aminotransferase: glycosylase/DNA-(apurinic cysteine ligase CoaBC: 1,4-benzoquinol methyltransferase UbiG: bifunctional hydroxymethylpyrimidine/ deoxyphosphogluconate D-glycerate D-threitol degradation lactoylglutathione HMPREF9701_RS04575 HMPREF9701_RS27195 subunit beta: subunit methyltransferase HMPREF9701_RS20065 HMPREF9701_RS27195 HMPREF9701_RS31450 HMPREF9701_RS08690 methylase UbiE: cobalt- porphobilinogen α α ligase/YqeY domain hydratase 2/2- HMPREF9701_RS20000 HMPREF9701_RS09945 HMPREF9701_RS02575 methylase UbiE: methylase UbiE: methylase UbiE: (E)-3- 1-(β-D cob(I)yrinic acid a,c-diamide Co -[ -(5-methylbenzimidazolyl) phosphomethylpyrimidine gln gln acetyl phosphate HMPREF9701_RS05840 hydroxyacylglutathione a nascent peptidoglycan or apyrimidinic site) lyase: sirohydrochlorin precorrin-3B HMPREF9701_RS14825 hydroxymethylpyrimidine 5-(2-hydroxyethyl) glutaminyl-tRNA fumarate reductase: methylisocitrate aldolase/4-hydroxy-2- penicillin-binding protein 2: acetyl-CoA propanoyl-CoA HMPREF9701_RS17020 B: HMPREF9701_RS11780 HMPREF9701_RS11315 HMPREF9701_RS11315 HMPREF9701_RS11315 acetoacetyl-CoA HMPREF9701_RS31455 HMPREF9701_RS11315 7,8- adenosyltransferase: 2-methoxy- ferroheme b ]-Coβ-adenosylcobamide kinase: fusion protein: NAD(P)-dependent D-erythrulose with (L-alanyl-γ-D- 4-hydroxyphenylpyruvate phe HMPREF9701_RS11475 4'-phosphopantetheine D-glyceraldehyde 967 6-methoxy-3-methyl- 6-methoxy-3-methyl-2- 3-methyl-6-methoxy- (methoxycarbonyl) ribofuranosyl) RS23620 hydroxymethylbilane -4-methylthiazole biosynthesis via transamidation HMPREF9701_RS20040 oxoglutarate aldolase: hydrolase: HMPREF9701_RS04650 a 5-methylcytosine + F0F1 ATP + dihydroneopterin GTP kinase/ HMPREF9701_RS23515 dehydratase: D-threitol di-trans,octa-cis a 3'-terminal a 5'-phospho- trp pent-2-enedioate an alcohol MQH H H HMPREF9701_RS01330 6-(all-trans- HMPREF9701_RS04140 an L-glutaminyl- acetate/propionate alcohol dehydrogenase: glutamyl-meso-2,6- 3-phosphate in 16S rRNA 2-all-trans-decaprenyl- all-trans-heptaprenyl- 2-octaprenyl-1,4- nicotinamide 2 synthase precorrin-3B C(17)- chorismate synthase: phosphomethylpyrimidine HMPREF9701_RS17345 HMPREF9701_RS30550 -undecaprenyl unsaturated sugar [DNA] [tRNA Gln ] HMPREF9701_RS20080 xylitol degradation D-threitol dehydrogenase: 1,4-benzoquinol 1,4-benzoquinol benzoquinone methyltransferase: dihydroneopterin aldolase: octaprenyl)phenol HMPREF9701_RS09640 kinase: bifunctional succinate family kinase: HMPREF9701_RS07550 diaminopimeloyl- adenosylcobinamide a tRNA Gln glu D-glyceraldehyde HMPREF9701_RS05850 diphosphate HMPREF9701_RS06710 HMPREF9701_RS24355 aminodeoxychorismate bifunctional 3,4- aconitate hydratase: acnA HMPREF9701_RS14915 2-phospho-D-glycerate (R)-lactate D-alanyl-D-alanine) HMPREF9701_RS26335 hydroxymethylpyrimidine ethanol 3-phosphate cobalt-factor III synthase, component I: dihydroxy-2-butanone- preuroporphyrinogen 4-methyl-5-(2- xylitol D-erythrulose D-erythrulose pentapeptide NAD(P) RS29705 6-(hydroxymethyl) adenosylcobinamide kinase/ cis-aconitate + + precorrin-4 HMPREF9701_RS12335 4-phosphate synthase/ HMP-PP phosphooxyethyl) acetate erythritol/L-threitol 4-phosphate D-lactate dehydrogenase: H transhydrogenase H -7,8-dihydropterin kinase/adenosylcobinamide- 2-methoxy-6-all uroporphyrinogen- thiazole phosphomethylpyrimidine an L-glutamyl- 4-amino-4- GTP cyclohydrolase II: bifunctional aconitate dehydrogenase: HMPREF9701_RS26560 precorrin-4 C(11)- phosphate trans-octaprenyl- kinase: Gln undecaprenyl- an odd numbered a 2-methyl 2-methoxy-6-all 2-amino-4-hydroxy-6- HMPREF9701_RS22995 III synthase: [tRNA ] HMPREF9701_RS05840 an apo [peptidyl- a [protein]-L- methyltransferase: deoxychorismate guanylyltransferase: 1,4-benzoquinol HMPREF9701_RS26335 hydratase 2/2- straight chain branched 2,3,4- oleate coenzyme A adenosylcobinamide nicotinate PRPP trans-nonaprenyl- citrate an aromatic hydroxypyruvate DMKH2-13 hydroxymethyldihydropteridine HMPREF9701_RS09645 thiamine phosphate glu aspartyl-tRNA(Asn)/ D-xylulose D-erythrulose pyruvate diphospho-N- carrier protein] met methionine ser HMPREF9701_RS06690 aminodeoxychorismate 2,5-diamino-6-(5-phospho-D- HMPREF9701_RS01285 bifunctional glutamate--tRNA ligase: methylisocitrate D-erythrose 2,3,4-saturated saturated fatty acid long-chain acyl- adenosylcobinamide nicotinate 1,4-benzoquinol aconitate hydratase: acnA amino acid hydroxypyruvate peptide-methionine arsenite RS10130 arsenite cobalt-precorrin-3 diphosphokinase: synthase: glutamyl-tRNA (Gln) 4-phosphate acetylmuramoyl- UDP-N-acetyl- long-chain acyl- 4'-phosphopantetheinyl aspartate/tyrosine/ bifunctional aspartate/tyrosine/ bifunctional threonine/serine RS26785 lyase: ribosylamino)pyrimidin-4(3H)-one demethylmenaquinone uroporphyrinogen-III HMP-PP HMPREF9701_RS13520 an L-glutamyl- dehydratase: 4-phosphate L-alanyl-γ-D- α-D-glucosamine fatty acid long-chain acyl- CoA synthetase: kinase/adenosylcobinamide- phosphoribosyltransferase: bifunctional aconitate isomerase: demethylmenaquinone (S)-S-oxide reductase: HMPREF9701_RS09845 adenosyl-cobinamide HMPREF9701_RS26315 adenosylcobinamide-GDP biosynthesis amidotransferase subunit CoA synthetase: transferase: aromatic aminotransferase: demethylmenaquinone aromatic aminotransferase: dehydratase: precorrin-5 HMPREF9701_RS12330 bifunctional methyltransferase/2- [tRNA Glu ] HMPREF9701_RS20080 undecaprenyldiphospho- CoA synthetase: HMPREF9701_RS04965 phosphate HMPREF9701_RS23160 HMPREF9701_RS01365 HMPREF9701_RS28420 (7,8-dihydropterin- phosphate glutamyl-L-lysyl- HMPREF9701_RS04965 HMPREF9701_RS25555 methyltransferase/2- hydratase 2/2- methyltransferase/2- 5,6-dimethylbenzimidazole uroporphyrinogen from cobyrinate a,c-diamide a tRNA glu A: HMPREF9701_RS04750 HMPREF9701_RS04965 HMPREF9701_RS28670 HMPREF9701_RS28670 HMPREF9701_RS08845 6-yl)methyl diaminohydroxyphosphoribosylaminopyrimidine methoxy-6-polyprenyl- thiamine diphosphate aconitate hydratase: acnA D-alanyl-D-alanine muramoylpentapeptide beta-N- [+ 10 isozymes] guanylyltransferase: nicotinate methylisocitrate hydroxypyruvate methoxy-6-polyprenyl- peptide-methionine 2+ 2+ precorrin-6A synthase 4-aminobenzoate decarboxylase: thiamine Macromolecule Modification D-xylulose ditrans,octacis- an odd numbered [+ 10a isozymes] 2-methyl holo-ACP synthase: methoxy-6-polyprenyl- Hg RS00600 Hg deaminase/5-amino-6-(5-phosphoribosylamino) adenosylcobinamide 1,4-benzoquinol cob(II)yrinate biosynthesis II (Bacillus) [+ 2 isozymes] D-erythrose acetylglucosaminyltransferase: [+ 10 isozymes] HMPREF9701_RS01285 aspartate/tyrosine/ dehydratase: aspartate/tyrosine/ threonine/serine (deacetylating): diphosphate phosphate 5-phosphate undecaprenyldiphospho- HMPREF9701_RS03335 phosphoribosyltransferase: 1,4-benzoquinol isomerase: 1,4-benzoquinol (S)-S-oxide reductase: RS24410 cobalt-precorrin-4 uracil reductase RibD: HMPREF9701_RS03045 kinase/adenosylcobinamide- nicotinate-nucleotide-- methylase UbiE: HMPREF9701_RS22560 an L-glutaminyl- D-threo-isocitrate 4-phosphate HMPREF9701_RS04620 straight chain branched diphosphate AMP oleoyl-CoA adenosyl-cobinamide aromatic aminotransferase: aromatic aminotransferase: dehydratase: HMPREF9701_RS06685 a,c-diamide cob(I)yrinic acid a,c-diamide thiamine diphosphate β diphosphate AMP AMP diphosphate a holo [peptidyl- HMPREF9701_RS10395 methylase UbiE: HMPREF9701_RS20080 HMPREF9701_RS17840 methylase UbiE: HMPREF9701_RS05390 dimethylbenzimidazole superpathway of pyridoxal 5'-phosphate biosynthesis and salvage Gln N-acetyl-(N-acetyl- -D- 2,3,4-saturated 2,3,4-saturated 3',5'-ADP HMPREF9701_RS09945 HMPREF9701_RS09945 a protein-L- HMPREF9701_RS27080 5-amino-6-(5-phospho- phosphate HMPREF9701_RS11315 thiamine-phosphate kinase: HMP-PP [tRNA ] protein S-nitrosylation and denitrosylation UDP carrier protein] phosphate tartronate HMPREF9701_RS11315 phosphoribosyltransferase: coproporphyrinogen III adenosyltransferase: biosynthesis I (E. coli) NADP-dependent queuosine biosynthesis Alcohol Degradation glucosaminyl)muramoyl- NaMN 4-(methylsulfanyl) HMPREF9701_RS11315 D-threo-isocitrate an aromatic methionine- guanylyltransferase: 6-methoxy-3- HMPREF9701_RS23365 thiamine phosphate fatty acyl CoA fatty acyl-CoA 6-methoxy-3-methyl-2- semialdehyde pyruvate Hg 2+ RS00605 Hg 2+ precorrin-6A D-ribosylamino)uracil HMPREF9701_RS01330 isocitrate dehydrogenase: γ -2-oxobutanoate 2-oxo-acid menaquinol-13 HMPREF9701_RS01285 HMPREF9701_RS01415 methyl-2-all- D-erythrose cob(II)yrinate a,c- synthase: ile a [protein]- L-alanyl- -D-glutamyl-L- all-trans-nonaprenyl- (S)-S-oxide 7,8- bifunctional HMP-PP isoleucine--tRNA ligase: HMPREF9701_RS16885 lysyl-D-alanyl-D-alanine trans-octaprenyl- 4-phosphate thiamine diamide-[corrinoid HMPREF9701_RS26315 L-cysteine preQ Detoxification glycerol and glycerophosphodiester degradation 1,4-benzoquinol RS04025 cobalt- dihydropteroate diaminohydroxyphosphoribosylaminopyrimidine adenosylcobinamide- α-ribazole 5'-phosphate thiamine phosphate thiamine HMPREF9701_RS11710 0 ethylene glycol degradation D-ribulose 5-phosphate 1,4-benzoquinol diphosphate adenosyltranferase] an L-isoleucyl- NADP-dependent NADPH-dependent 7- precorrin-5A GDP synthase: Ile a reduced bifunctional deaminase/5-amino-6-(5-phosphoribosylamino) phosphate [tRNA ] isocitrate dehydrogenase: cyano-7-deazaguanine cobalt-precorrin protoporphyrinogen IX HMPREF9701_RS26315 Ile arsenate detoxification glycerol a glycerophosphodiester a 3-methyl- an apo-[LYS2 L- 2-methoxy-6-all keto- a [protein]-L- H O c-type uracil reductase RibD: HMPREF9701_RS03045 a tRNA HMPREF9701_RS16805 a nucleoside 3-(all-trans-heptaprenyl) a ribonucleoside 2 precorrin-6B tetrahydrofolate synthase/ bifunctional 3,4- thiamine thiamine-phosphate kinase: reductase QueF: reactive oxygen species degradation superoxide ethylene glycol quinoxaline-2- branched 2,3,4- a ribonucleic acid (3S)-citryl-CoA hydantoin trans-hexaprenyl- a (2E)-docos- DMK-12 3'-AMP cytochrome 5A hydrolase: adenosylcobinamide- 4-phospho- a [protein] 3- II (glutaredoxin) ATP cob(II)inamide aryl-carrier protein 2-aminoadipyl- coenzyme A benzene-1,2-diol phenylpyruvate methionine cytochrome dihydrofolate synthase: dihydroxy-2-butanone- 5-amino-6-(5-phospho- cob(I)yrinate a,c- phosphate HMPREF9701_RS03480 radicals degradation NAD(P)-dependent carboxyl adenylate triphosphate 5'-monophosphate 2-enoyl-[acp] c oxidase an oxidized 15 GDP ribazoletransferase: D-erythronate HMPREF9701_RS23365 nitrosothio- saturated fatty acid carrier-protein] bifunctional 2-polyprenyl-6- citrate lyase subunit dihydropyrimidinase: 1,4-benzoquinol 4-hydroxyphenylpyruvate bifunctional peptide-methionine bifunctional 2',3'- HMPREF9701_RS06695 precorrin-6B (C ) HMPREF9701_RS13495 4-phosphate synthase/ D-ribitylamino)uracil Aromatic Compound Biosynthesis 2-oxoglutarate acyl carrier protein: long-chain acyl- DNA-directed 4'-phosphopantetheinyl bifunctional 5'-nucleotidase: bifunctional 3- O c-type RS09580 diamide-[corrinoid preQ glycerol kinase: glycerophosphoryl diester alcohol dehydrogenase: 2 HMPREF9701_RS08495 3-demethylubiquinol-8 L-alanine 1 arsenate cob(I)yrinic acid a,c-diamide hydroxyphenol methylase/ beta/citryl-CoA lyase: HMPREF9701_RS01645 dioxygenase: demethylmenaquinone (R)-S-oxide reductase: cyclic-nucleotide 2'- cobalt- methyltransferase: GTP cyclohydrolase II: thiamine-phosphate kinase: thiamine superoxide superoxide HMPREF9701_RS03395 CoA synthetase: RNA polymerase: transferase: demethylmenaquinone HMPREF9701_RS08585 hydroxydecanoyl-ACP cytochromea reduced 7,8-dihydrofolate adenosyltranferase] phenylmercury acetate degradation HMPREF9701_RS12955 phosphodiesterase: HMPREF9701_RS07550 adenosyltransferase: 3-demethylubiquinol 3-O- HMPREF9701_RS20070 HMPREF9701_RS22815 HMPREF9701_RS26370 precorrin-5B HMPREF9701_RS06700 adenosylcobalamin HMPREF9701_RS23365 diphosphate tRNA guanosine(34) arsenate reductase acyl carrier protein: HMPREF9701_RS04965 HMPREF9701_RS22625 HMPREF9701_RS25555 hydantoinase/oxoprolinase methyltransferase/2- dehydratase/trans-2- methyltransferase/2- phosphodiesterase/ H O c-type monoglutamate HMPREF9701_RS22995 bifunctional 2-polyprenyl-6- protoporphyrin IX chorismate biosynthesis I superoxide dismutase [Fe]: glycerol kinase: HMPREF9701_RS29415 glycolaldehyde bifunctional 2 cytochrome- ATP:cob(I)alamin leu salicylate biosynthesis I (glutaredoxin): superoxide dismutase [Fe]: HMPREF9701_RS01330 methyltransferase UbiG: citryl-CoA lyase: family protein: 4-hydroxyphenylpyruvate methoxy-6-polyprenyl- peptide-methionine 3'-nucleotidase: salvage from cobalamin adenosylcobalamin (3R)-3-hydroxy-2-oxo- transglycosylase Tgt: HMPREF9701_RS16530 HMPREF9701_RS18435 [+ 10a isozymes]3-methyl- HMPREF9701_RS22630 holo-ACP synthase: methoxy-6-polyprenyl- metallophosphatase/ decenoyl-ACP isomerase: c oxidase, cytochrome 1-deoxy-L-glycero- hydroxyphenol methylase/ adenosyltransferase: thiamine leucine--tRNA ligase: HMPREF9701_RS16530 mercuriphenyl HMPREF9701_RS24955 [+ 2 isozymes] a quinoxaline-2- HMPREF9701_RS14825 an oxidized precorrin-7 5'-phosphate HMPREF9701_RS22475 HMPREF9701_RS04030 glycolaldehyde ATP:cob(I)alamin HMPREF9701_RS03335 HMPREF9701_RS15160 HMPREF9701_RS10255 1,4-benzoquinol dioxygenase: 5'-nucleotidase: HMPREF9701_RS24225 1,4-benzoquinol (R)-S-oxide reductase: HMPREF9701_RS19540 cbb3-type ARP 3-demethylubiquinol 3-O- ferrochelatase: 4 phosphooxybutanoate HMPREF9701_RS29775 diphosphate HMPREF9701_RS29225 an L-leucyl- D-erythrose 4-phosphate superoxide dismutase: acetate branched [+ 2 isozymes] a holo-[LYS2 L- 2-methoxy-6-(all-trans O c-type RS09585 tetrulose 4-phosphate cob(I)alamin a [protein]- a 7-aminomethyl-7- [+ 4 isozymes] superoxide dismutase: dehydrogenase: adenosyltransferase: AMP carboxyl-[aryl- diphosphate AMP acetyl-CoA oxaloacetate methylase UbiE: HMPREF9701_RS13380 a (3Z)-docos- methylase UbiE: HMPREF9701_RS05380 2 precorrin-7 (C 5 ) methyltransferase UbiG: HMPREF9701_RS15335 3-phosphoserine/ Leu chorismate S-nitrosoglutathione HMPREF9701_RS09430 2,3,4-saturated a ribonucleic acid 2-aminoadipyl- 3',5'-ADP -heptaprenyl)phenol N-carbamoylglycine HMPREF9701_RS08690 a protein-L- cytochrome cobalt- cob(I)yrinic acid a,c-diamide [tRNA ] glyoxylate cycle deazaguanosine 34 arsenite HMPREF9701_RS09430 hydrogen sn-glycerol HMPREF9701_RS07945 HMPREF9701_RS29775 carrier protein] (2-hydroxyphenyl) 3-enoyl-[acp] HMPREF9701_RS11315 adenosine Leu L-cysteine HMPREF9701_RS11315 methionine- methyltransferase: a 7,8-dihydrofolate HMPREF9701_RS14825 phosphohydroxythreonine adenosyltransferase: a tRNA 3-deoxy-7- isochorismate synthase: 3-phosphate fatty acyl-CoA carrier-protein] 6-methoxy-3-methyl-2- acetate a ribonucleoside RS12585 precorrin-6A 6,7-dimethyl-8- ferroheme b glutathione-glutaredoxin in tRNA hydrogen peroxide aldehyde dehydrogenase triphosphate adenosylcobinamide menaquinol-12 HMPREF9701_RS06700 transaminase: phosphoheptulonate HMPREF9701_RS14905 S-(hydroxymethyl) all-trans-hexaprenyl- (R)-S-oxide cobalt-precorrin- ribityllumazine synthase: HMPREF9701_RS01330 redox reactions tRNA preQ1(34) S- peroxide cob(II)alamin adenosylcobalamin ubiquinol-8 adenosyl- synthase: isochorismate succinate acetyl-CoA glyoxylate glutathione arsenite-translocating catalase: (NAD(+)): 1,4-benzoquinol dihydrofolate reductase: HMPREF9701_RS22990 HMPREF9701_RS14840 RS15800 6A reductase: precorrin-8x dehydrogenase/class III adenosylmethionine ATPase: HMPREF9701_RS21350 2+ HMPREF9701_RS30475 HMPREF9701_RS30930 4-phosphooxy- cobyrinate glutathione HMPREF9701_RS04535 Hg benzene acetate HMPREF9701_RS06705 6,7-dimethyl-8- cob(I)yrinic acid a,c-diamide molybdenum cofactor biosynthesis isochorismate- alcohol dehydrogenase: ribosyltransferase- HMPREF9701_RS10130 catalase: L-threonine a,c-diamide 3-deoxy-7- malate synthase G: a ribonucleoside precorrin-8X ribityllumazine synthase: adenosyltransferase: pyruvate lyase: isomerase QueA: HMPREF9701_RS21350 O DHAP glycolate (15Z)- a reduced 3-(all-trans-nonaprenyl) a trans-delta2- a damaged pro RS19295 pro cobalt- a tetrahydrofolate val HMPREF9701_RS20000 2 mercury(II) reductase: a purine pristanate [EntB aryl- 3-demethylubiquinol-9 5-chloroprotocatechuate a cytosine in DNA DMKH2-11 methylmutase: HMPREF9701_RS01330 cobyric acid synthase: valine--tRNA ligase: phosphoheptulonate HMPREF9701_RS25685 tetracosenoate electron-transfer UQ coenzyme A cis-delta15- 2',3'-cyclic asp 3'-GMP precorrin-6B HMPREF9701_RS09815 D-glyceraldehyde 4-hydroxythreonine- HMPREF9701_RS14910 isocitrate lyase/ HMPREF9701_RS12885 HMPREF9701_RS00595 ribonucleoside adenosylcobinamide carrier protein] benzene-1,2-diol DNA pyrimidine cobH cob(II)alamin- pyruvate HMPREF9701_RS01350 a reduced synthase: S-(hydroxysulfenamide) H O hydroxyl radical long-chain acyl- long-chain acyl- flavoprotein bifunctional 2-polyprenyl-6- bifunctional 2-polyprenyl-6- protocatechuate C34:2-[acp] bifunctional DNA- DNA (cytosine-5-)- phosphate bifunctional bifunctional 2',3'- GTP 3-phosphate 4-phosphate HMPREF9701_RS09710 an L-valyl- an epoxyqueuosine 34 2 electron transfer 4'-phosphopantetheinyl bifunctional 3- bifunctional 2',3'- bifunctional aspartate azurin HMPREF9701_RS22225 phosphoenolpyruvate glutathione O 5'-triphosphate adenosylcobinamide CoA synthetase: CoA synthetase: 4,5-dioxygenase: methyltransferase: [corrinoid cys ATP (R)-1-amino- glutaredoxin [tRNA Val ] salicylate 2 0 flavoprotein-ubiquinone transferase: hydroxyphenol methylase/ hydroxyphenol methylase/ hydroxydecanoyl-ACP formamidopyrimidine demethylmenaquinone cyclic-nucleotide 2'- hydrogenobyrinate dehydrogenase PdxA: mutase family protein: in tRNA arsenite Hg cyclic-nucleotide 2'- aminotransferase/ 6,7-dimethyl-8-(1-D-ribityl)lumazine 1-deoxy-D-xylulose-5- 2-propanol O adenosylcobyrate Val kinase/adenosylcobinamide- HMPREF9701_RS04965 HMPREF9701_RS04965 3-demethylubiquinol 3-O- 3-demethylubiquinol 3-O- HMPREF9701_RS22845 glycosylase/DNA-(apurinic HMPREF9701_RS00750 phosphodiesterase/ adenosyltranferase] HMPREF9701_RS19455 a tRNA 3-deoxy-D-arabino- oxidoreductase: HMPREF9701_RS25555 dehydratase/trans-2- phosphodiesterase/ methyltransferase/2- L-aspartate beta- phosphate synthase: glutaredoxin 3: HMPREF9701_RS21070 epoxyqueuosine reductase: phosphate HMPREF9701_RS22850 RS25935 L-cysteine:[protein GTP 3',8-cyclase MoaA: -2-phosphate [+ 10 isozymes] [+ 10 isozymes] HMPREF9701_RS21620 methyltransferase UbiG: methyltransferase UbiG: decenoyl-ACP isomerase: or apyrimidinic site) lyase: DNA (cytosine-5-)- 3'-nucleotidase: methoxy-6-polyprenyl- 3'-nucleotidase: cobalt-precorrin-7 hydrogenobyrinate riboflavin synthase: [+ 2 isozymes] HMPREF9701_RS12395 heptulosonate 7-phosphate isocitrate lyase: an oxidized holo-ACP synthase: decarboxylase: 10 cysteine] sulfurtransferase: HMPREF9701_RS30490 HMPREF9701_RS09590 adenosylcobinamide- HMPREF9701_RS02680 guanylyltransferase: HMPREF9701_RS14825 HMPREF9701_RS14825 [+ 3 isozymes] HMPREF9701_RS11475 methyltransferase: 1,4-benzoquinol HMPREF9701_RS19540 a,c-diamide synthase: N -formyl-tetrahydrofolate biosynthesis 3-amino-1- (Z)-15- H + UQH electron-transfer HMPREF9701_RS03335 6-chloro-2-hydroxy- HMPREF9701_RS24225 HMPREF9701_RS19540 HMPREF9701_RS28225 HMPREF9701_RS08680 two reduced HMPREF9701_RS06270 2 2-methoxy-6-(all-trans an apyrimidinic HMPREF9701_RS28655 (8S)-3',8-cyclo-7,8- 1-deoxy-D-xylulose pyridoxine phosphate synthase: 3-dehydroquinate synthase: hydroxylamine 34 HMPREF9701_RS01285 AMP diphosphate AMP diphosphate pristanoyl-CoA a holo-[EntB aryl- a cis,cis-delta3,15- HMPREF9701_RS02025 a ribonucleoside methylase UbiE: RS24800 bifunctional cobalt- HMPREF9701_RS01280 cob(I)alamin- hydroxyacetone D-threo-isocitrate (S)-malate a queuosine a purine adenosyl- tetracosenoyl-CoA flavoprotein 3',5'-ADP ubiquinol-9 4-carboxymuconate- asp asp an [L-cysteine a carboxy-adenylated HMPREF9701_RS11930 cysteine residues HMPREF9701_RS10595 carrier protein] -nonaprenyl)phenol site in DNA a 5-methylcytosine [+ 3 isozymes] guanosine [corrinoid dihydroguanosine 5-phosphate 1-phosphate in tRNA Amino Acid Degradation ribonucleoside cobinamide 6-semialdehyde C34:2-[acp] 3'-phosphate HMPREF9701_RS11315 precorrin-7 (C(5))- hydrogenobyrinate a tetrahydrofolate riboflavin desulfurase]-S- [small subunit of pyridoxamine adenosyl- in a protein bifunctional aconitate in DNA oxaloacetate RS28220 adenosyltranferase] 5'-triphosphate ala 5'-diphosphate phosphate menaquinol-11 methyltransferase/cobalt- a,c-diamide pyridoxine/ cobinamide glutathione-peroxide alanine--tRNA ligase: 3-dehydroquinate hydratase 2/2- ala ala bifunctional riboflavin ATP:cob(I)alamin sulfanyl-L-cysteine molybdopterin synthase] cyclic pyranopterin pyridoxine 5'- RS07020 precorrin-6B (C(15)) aerobic cobaltochelatase: pyridoxal/ pyridoxine/ phosphate redox reactions HMPREF9701_RS28935 an L-alanyl- methylisocitrate L-valine degradation I kinase/FAD synthetase: adenosyltransferase: monophosphate phosphate synthase: malate dehydrogenase: L-leucine degradation I L-tyrosine degradation I L-tryptophan degradation to L-histidine degradation II RS27250 -methyltransferase: pyridoxamine pyridoxal/ adenosylcobinamide Ala type II 3-dehydroquinate dehydratase: ammonium RS16600 HMPREF9701_RS19375 methionine synthase: synthase MoaC: HMPREF9701_RS03340 [tRNA ] 2-amino-3-carboxymuconate HMPREF9701_RS06700 HMPREF9701_RS11715 HMPREF9701_RS29775 pyridoxamine Ala dehydratase: HMPREF9701_RS20060 lipoprotein posttranslational an N-formyl-L- a 3-(all-trans a trans-delta2- HMPREF9701_RS19380 kinase: pdxK kinase/adenosylcobinamide- guanylyl molybdenum GSSG a tRNA HMPREF9701_RS20080 + a ribonucleoside HMPREF9701_RS21610 HMPREF9701_RS14255 val semialdehyde acetoacetate linoleate an apo-[aryl- 3-demethylubiquinol-7 -polyprenyl) NAD NADPH DMKH2-10 cob(I)yrinic acid a,c-diamide kinase: pdxK cofactor biosynthesis HMPREF9701_RS22790 modification his O-acetyl-L-serine hydrogen selenide methionylaminoacyl- coenzyme A glyoxylate ser cis-delta21- a malonyl-[acp] asp cobaltochelatase [+ 2 isozymes] FMN a thiocarboxylated phosphate aconitate leu tyr carrier protein] 3'-phosphate IMP cobalt-precorrin-8 adenosyltransferase: cyclic pyranopterin pyridoxal acetoacetate--CoA ligase: long-chain acyl- tRNA 4'-phosphopantetheinyl bifunctional 2-polyprenyl-6- benzene-1,2-diol C40:2-[acp] beta-ketoacyl-[acyl-carrier- NAD(P)(+) bifunctional subunit CobN: [small subunit of pyridoxamine guanylyltransferase: MoO - type II 3-dehydroquinate a [prolipoprotein]- branched-chain amino trp O-acetylhomoserine peptide deformylase: aminotransferase bifunctional 2-polyprenyl-6- bifunctional 3- bifunctional 2',3'- bifunctional aspartate pyridoxine 5'-phosphate 2 hydratase: acnA branched-chain amino aspartate/tyrosine/ histidine ammonia-lyase: HMPREF9701_RS15755 CoA synthetase: bifunctional riboflavin HMPREF9701_RS01330 molybdopterin synthase] phosphate HMPREF9701_RS01285 dehydratase: aminocarboxypropyltransferase/ HMPREF9701_RS14110 transferase: class V-fold PLP- hydroxyphenol methylase/ hydroxyphenol methylase/ hydroxydecanoyl-ACP protein] synthase II: transhydrogenase cyclic-nucleotide 2'- demethylmenaquinone guanosine aminotransferase/ RS03370 RS10880 HMPREF9701_RS08795 5'-phosphate molybdopterin glutathione- L-cysteine acid transaminase: acid transaminase: aromatic aminotransferase: tryptophan 2,3- HMPREF9701_RS30190 kinase/FAD synthetase: adenosylcob(III) cis-aconitate acetyl-CoA oxaloacetate cysteine synthase: acetoacetate--CoA ligase: HMPREF9701_RS04965 HMPREF9701_RS25555 dependent enzyme: 3-demethylubiquinol 3-O- 3-demethylubiquinol 3-O- dehydratase/trans-2- HMPREF9701_RS03390 (Re/Si-specific): phosphodiesterase/ methyltransferase/2- monophosphate reductase: L-aspartate beta- RS29495 dihydrofolate reductase: pyridoxine/ adenosylcobinamide- cofactor molybdopterin- disulfide reductase: HMPREF9701_RS23505 prolipoprotein HMPREF9701_RS07820 HMPREF9701_RS09945 dioxygenase: urocanate peptide deformylase: cob(II)yrinate alamin-[corrinoid molybdopterin synthase asn HMPREF9701_RS07820 4-methyl-2- HMPREF9701_RS29875 [+ 10 isozymes] methyltransferase UbiG: HMPREF9701_RS07680 methoxy-6-polyprenyl- HMPREF9701_RS11715 pyridoxamine 5'- pyridoxamine 5'- GDP HMPREF9701_RS15985 HMPREF9701_RS09950 HMPREF9701_RS10345 HMPREF9701_RS27460 holo-ACP synthase: HMPREF9701_RS05440 methyltransferase UbiG: decenoyl-ACP isomerase: a 3- [+ 2 isozymes] 3'-nucleotidase: HMPREF9701_RS11985 decarboxylase: a,c-diamide HMPREF9701_RS30930 adenosyltranferase] pyridoxal/ guanine dinucleotide 3-dehydroshikimate bifunctional aconitate diacylglyceryl transferase: 3-methyl-2- oxopentanoate aspartate/tyrosine/ a L-methionylaminoacyl- HMPREF9701_RS14825 HMPREF9701_RS07685 1,4-benzoquinol cobyrinate catalytic subunit MoaE: urocanate hydratase: cysteine synthase CysM: HMPREF9701_RS03335 gly hydroxypyruvate a 2-methoxy- HMPREF9701_RS14825 HMPREF9701_RS24225 oxodocosanoyl- HMPREF9701_RS19540 HMPREF9701_RS28225 FAD cob(I)yrinic acid a,c-diamide pyridoxamine phosphate oxidase: phosphate oxidase: biosynthesis protein B: an L-asparaginyl- hydratase 2/2- HMPREF9701_RS01145 aromatic aminotransferase: tryptophan 2,3- AMP diphosphate acetoacetyl-CoA AMP diphosphate linoleoyl-CoA formate gcv system: HMPREF9701_RS03100 oxobutanoate tRNA a holo-[aryl- ubiquinol-7 a cis,cis-delta3,21- HMPREF9701_RS07690 a ribonucleoside methylase UbiE: GMP a 7,8-dihydrofolate a 5-methyltetrahydrofolate kinase: pdxK HMPREF9701_RS28385 HMPREF9701_RS28385 HMPREF9701_RS03135 Asn shikimate 5- methylisocitrate dioxygenase: HMPREF9701_RS30195 HMPREF9701_RS09730 3',5'-ADP 6-(all-trans- [acp] ala RS11820 cobyrinate a,c- HMPREF9701_RS21710 adenosyltransferase: phosphopantothenate biosynthesis I [tRNA ] a [prolipoprotein]-S- HMPREF9701_RS28670 carrier protein] C40:2-[acp] + HMPREF9701_RS11315 Asn shikimate dehydrogenase: polyprenyl)phenol NADP NADH serine HMPREF9701_RS01330 molybdenum cofactor glutathione tRNA dehydrogenase: dehydratase: diacylglyceryl-L-cysteine 4-hydroxyphenylpyruvate HMPREF9701_RS09995 4-imidazolone- acetate L-selenocysteine RS17755 diamide synthase: HMPREF9701_RS22805 N-formylkynurenine menaquinol-10 RS09050 hydroxymethyltransferase: glyA molybdopterin 3-methyl-2- folate transformations I guanylyltransferase MobA: HMPREF9701_RS22805 HMPREF9701_RS20080 5-propanoate HMPREF9701_RS01280 PLP citrate synthase: isovaleryl-CoA 4-hydroxyphenylpyruvate thymidylate[+ 2 isozymes] synthase: adenosylcobalamin oxobutanoate guanylyl HMPREF9701_RS30495 aconitate lipoprotein cob(II)yrinate molybdopterin HMPREF9701_RS20025 isobutanoyl-CoA dioxygenase: arylformamidase: imidazolonepropionase: HMPREF9701_RS30925 molybdenum shikimate hydratase: acnA signal peptidase: isovaleryl-CoA a,c-diamide adenylyltransferase: 3-methyl-2-oxobutanoate a tetrahydrofolate HMPREF9701_RS22815 HMPREF9701_RS09975 HMPREF9701_RS30205 3D-(3,5/4)- 3-(all-trans a 3- a (7Z)-3- a [protein]- RS29585 NAD biosynthesis I (from aspartate) hydroxymethyltransferase: cofactor HMPREF9701_RS00650 dehydrogenase: a single sn-glycero-3- AsbD acyl- 3-demethylubiquinol-6 bifunctional a (6S)-5- HMPREF9701_RS15580 shikimate kinase: 18-hydroxyoleate decanoate coenzyme A glyoxylate ser trihydroxycyclohexane- -decaprenyl) oxodocosanoyl- oxohexacos- phe L-tyrosine met RS05935 met asp citrate HMPREF9701_RS19055 4-hydroxyphenylpyruvate N-formimino- stranded DNA phosphoethanolamine carrier protein 2'-deoxyadenosine dGDP methylenetetrahydrofolate formyltetrahydrofolate HMPREF9701_RS12360 aspartate--tRNA ligase: HMPREF9701_RS10590 lipoprotein exodeoxyribonuclease long-chain acyl- long-chain acyl- glycerophosphoryl diester bifunctional 2-polyprenyl-6- 1,2-dione benzene-1,2-diol [acp] 7-enoyl-[acp] phosphate RS25920 2-methyladeninyl adenosylcobamide molybdopterin 4-hydroxyphenylpyruvate dioxygenase: L-kynurenine L-glutamate 4'-phosphopantetheinyl aminotransferase 3D-(3,5/4)- bifunctional 2-polyprenyl-6- NAD(P)-dependent NAD(P)-dependent bifunctional aspartate protein-tyrosine- methylenetetrahydrofolate dehydrogenase/ 5-formyltetrahydrofolate formyltetrahydrofolate HMPREF9701_RS11355 an L-aspartyl- signal peptidase: [+ 2 isozymes] VII large subunit: CoA synthetase: CoA synthetase: phosphodiesterase: hydroxyphenol methylase/ ribonucleoside- biosynthesis from adenosylcobinamide-GDP asp adenine dinucleotide 2-dehydropantoate helix-turn-helix domain- biosynthesis HMPREF9701_RS13380 transferase: class V-fold PLP- trihydroxycyclohexane- hydroxyphenol methylase/ oxidoreductase: oxidoreductase: aminotransferase/ phosphatase: reductase [NAD(P)H]: methenyltetrahydrofolate deformylase: [tRNA asp ] HMPREF9701_RS11705 methylacrylyl-CoA 3-methylcrotonyl- formimidoylglutamate HMPREF9701_RS04965 HMPREF9701_RS04965 adenosine deaminase: diphosphate reductase: cyclo-ligase: containing protein: HMPREF9701_RS16525 HMPREF9701_RS29415 HMPREF9701_RS25555 dependent enzyme: 3-demethylubiquinol 3-O- 3-demethylubiquinol 3-O- HMPREF9701_RS12545 HMPREF9701_RS12545 RS25715 L-aspartate oxidase: molybdopterin asp CoA 1,2-dione acylhydrolase L-aspartate beta- HMPREF9701_RS14370 met RS04940 met HMPREF9701_RS07050 cyclohydrolase FolD: HMPREF9701_RS24300 2-dehydropantoate HMPREF9701_RS25070 tRNA homogentisate deiminase: [+ 10 isozymes] [+ 10 isozymes] [+ 2 isozymes] methyltransferase UbiG: HMPREF9701_RS17735 HMPREF9701_RS04470 2-methyladenine HMPREF9701_RS10055 molybdenumtransferase HMPREF9701_RS29815 an (S-diacyl-sn- exodeoxyribonuclease holo-ACP synthase: HMPREF9701_RS05440 (decyclizing): methyltransferase UbiG: a (3R)-3-[+ 6 isozymes] a (3R,7Z)-3-[+ 6 isozymes] decarboxylase: a 5,10- HMPREF9701_RS28555 a 5,10- 2-reductase: tyr a lipoprotein acetyl/propionyl/ HMPREF9701_RS30220 sn-glycerol HMPREF9701_RS14825 arsenate reductase ArsC: HMPREF9701_RS04475 2-iminosuccinate MoeA: glyceryl)-L-cysteinyl- VII small subunit: 18-hydroxyoleoyl- ethanolamine HMPREF9701_RS03335 gly hydroxypyruvate HMPREF9701_RS18470 6-(all-trans- HMPREF9701_RS14825 hydroxydocosanoyl- hydroxyhexacos- HMPREF9701_RS28225 nicotinate-nucleotide-- methylenetetrahydrofolate methenyltetrahydrofolate HMPREF9701_RS04250 shikimate 3-phosphate aspartate/tyrosine/ signal peptide methylcrotonyl- 3-hydroxy- N-formyl- AMP diphosphate diphosphate AMP decanoyl-CoA 3-phosphate a holo-[AsbD acyl- 5-deoxy-D- 2'-deoxyinosine HMPREF9701_RS00505 GDP RS24390 HMPREF9701_RS03130 [apolipoprotein] HMPREF9701_RS09600 CoA ubiquinol-6 decaprenyl)-2- [acp] 7-enoyl-[acp] a [protein]- dimethylbenzimidazole aromatic aminotransferase: (S)-3-hydroxy- 3',5'-ADP [+ 3 isozymes] quinolinate synthase NadA: [+ 3 isozymes] an N 10 - CoA carboxylase: L-kynurenine L-glutamate a single-stranded a ribonucleoside carrier protein] glucuronate keto- L-tyrosine predicted phosphoribosyltransferase: bifunctional molybdopterin bifunctional 3- methoxy-phenol RS01495 β HMPREF9701_RS09945 isobutanoyl-CoA HMPREF9701_RS19145 4-maleyl- oligodeoxyribonucleotide 5'-monophosphate ABC methylenetetrahydrofolate HMPREF9701_RS10050 -alanine gcv system: formyltetrahydrofolate kynureninase: N-formylglutamate phenylpyruvate urea urea HMPREF9701_RS01415 molybdenumtransferase (R)-pantoate tyr phosphoshikimate 1- aspartate/tyrosine/ HMPREF9701_RS19160 acetoacetate transporter dehydrogenase/ HMPREF9701_RS21710 tyrosine--tRNA ligase: HMPREF9701_RS09980 deformylase: quinolinate MoeA: adeninyl adenosylcobamide biosynthesis methionine synthase: carboxyvinyltransferase/ aromatic aminotransferase: an N-acyl-(S-diacyl- of urea methenyltetrahydrofolate bifunctional a (6S)-5- HMPREF9701_RS06980 an L-tyrosyl- a peptide acetyl/propionyl/ maleylacetoacetate HMPREF9701_RS30225 2-methyladenine HMPREF9701_RS30500 from adenosylcobinamide-GDP cytidylate kinase: Pentose Phosphate Pathways sn-glyceryl)-L- a (2R)-2-hydroxy a (7Z,10Z,13Z,16Z a 3- a (5Z)-3- (2Z,4E)-2- 4-hydroxy- HMPREF9701_RS21610 methylenetetrahydrofolate Tyr HMPREF9701_RS28670 methylcrotonyl-CoA isomerase: a (6S)-5- 3-demethylubiquinol- 4-hydroxy-2- a 3-oxoicosanoyl- RS29200 cyclohydrolase FolD: pantoate--beta- formyltetrahydrofolate [tRNA ] cysteinyl-[lipoprotein] (S)-3-hydroxy- 3-hydroxyanthranilate N-formylglutamate even numbered 7-hydroxylaurate octanoate glu ,19Z)-3-oxodocosa- glycerophosphoserine a protein oxodocosanoyl- oxotetracos- hydroxyhexa- 4-methyl-2- adenosylcobinamide- ribotide phosphate nicotinate-nucleotide MoO -molybdopterin Tyr HMPREF9701_RS14855 4-hydroxyphenylpyruvate 10 oxoglutarate RS26575 HMPREF9701_RS28555 2 alanine ligase: [+ 2 isozymes] dehydrogenase/ a tRNA carboxylase subunit alpha: HMPREF9701_RS16630 formyltetrahydrofolate [acp] dADP benzimidazolyl adenosylcobamide cofactor pentose phosphate pathway (non-oxidative branch) isobutanoate deformylase: straight chain 2,3,4- long-chain acyl- long-chain acyl- 7,10,13,16,19-pentaenoyl-[acp]NAD(P)-dependent glycerophosphoryl diester bifunctional 2-polyprenyl-6- 2-dehydro-3- metalloprotease TldD: [acp] NAD(P)-dependent NAD(P)-dependent 5-enoyl-[acp]NAD(P)-dependent 2,4-dienedioate oxoglutarate RS13050 GDP diphosphorylase HMPREF9701_RS12365 methenyltetrahydrofolate 5-enolpyruvoyl- HMPREF9701_RS17310 bifunctional 4-oxalocrotonate 4-carboxy-4-hydroxy- biosynthesis from adenosylcobinamide-GDP an N 10 - adenine 5-formyltetrahydrofolate 3-hydroxyisobutyrate maleylacetoacetate HMPREF9701_RS11265 saturated fatty acidlong-chain acyl- CoA synthetase: CoA synthetase: phosphodiesterase: hydroxyphenol methylase/ deoxyphosphogluconate ribonucleoside- (carboxylating): shikimate 3-phosphate tetrahydrofolate synthase/ oxidoreductase: HMPREF9701_RS04545 oxidoreductase: oxidoreductase: oxidoreductase: tautomerase: 2-oxoadipate pantoate--beta- cyclohydrolase FolD: cyclo-ligase: dehydrogenase: 3-methylglutaconyl- isomerase: CoA synthetase: HMPREF9701_RS04965 3-demethylubiquinol 3-O- aldolase/4-hydroxy-2- diphosphate reductase: adenosylcobinamide- formyltetrahydrofolate HMPREF9701_RS04275 bifunctional bifunctional D-ribulose HMPREF9701_RS04965 dihydrofolate synthase: HMPREF9701_RS12545 HMPREF9701_RS29415 metalloprotease PmbA: HMPREF9701_RS12545 HMPREF9701_RS12545 HMPREF9701_RS12545 aldolase/oxaloacetate alanine ligase: HMPREF9701_RS28555 HMPREF9701_RS24300 CoA HMPREF9701_RS17075 glu HMPREF9701_RS04965 HMPREF9701_RS27515 HMPREF9701_RS04470 GDP ribazoletransferase: benzimidazole nicotinate-nucleotide-- methylenetetrahydrofolate chorismate synthase: 5-phosphate tRNA processing HMPREF9701_RS17025 aminocarboxymuconate [+ 10 isozymes] [+ 10 isozymes] [+ 2 isozymes] methyltransferase UbiG: oxoglutarate aldolase: methylenetetrahydrofolate a (R)-2-hydroxy even HMPREF9701_RS13495 a (3R,7Z,10Z,13[+Z,16 6 isozymes]Z HMPREF9701_RS15570 a (3R)-3-[+ 6 isozymes] a (3R)-3-[+ 6 isozymes] a (3R,5Z)-3-[+ 6 isozymes] 4-oxalocrotonate decarboxylase: RS04270 RS24230 NaMN HMPREF9701_RS06015 dimethylbenzimidazole HMPREF9701_RS30860 methylglutaconyl- 4-fumaryl- semialdehyde [+ 10 isozymes] a (6S)-5- sn-glycerol HMPREF9701_RS14825 HMPREF9701_RS17345 HMPREF9701_RS04475 HMPREF9701_RS08495 dehydrogenase/ dehydrogenase/ a tRNA Trp (S)-methylmalonate- numbered straight 7-hydroxylauroyl- ,19Z)-3-hydroxydocosa- ser a peptide a peptide hydroxydocosanoyl- hydroxyicosanoyl- hydroxytetracos- HMPREF9701_RS22860 nicotinate-nucleotide-- a 5,10- ribulose-phosphate CoA hydratase: acetoacetate L-phenylalanine AMP diphosphate diphosphate AMP octanoyl-CoA formyltetrahydrofolate tautomerase: phosphoribosyltransferase: serine methenyltetrahydrofolate methenyltetrahydrofolate tryptophan--tRNA ligase: ribose-5-phosphate a polycistronic semialdehyde diphosphate AMP CoA 3-phosphate ubiquinol-10 pyruvate glyoxylate ADP α α dimethylbenzimidazole methenyltetrahydrofolate degradation II (anaerobic) chain 2,3,4-saturated 7,10,13,16,19-pentaenoyl-[acp] [acp] [acp] 5-enoyl-[acp] HMPREF9701_RS25680 pyruvate RS30265 Co -[ -(2- 5-methoxy-6-methylbenzimidazolyl adenosylcobamide (R)-pantothenate HMPREF9701_RS01415 hydroxymethyltransferase: glyA cyclohydrolase FolD: HMPREF9701_RS11555 an L-tryptophanyl- chorismate 3-epimerase: isomerase RpiA: tRNA precursor HMPREF9701_RS19150 fumarylacetoacetase: (3E)-2-oxohex- phosphoribosyltransferase: cyclohydrolase FolD: fatty acyl CoA methyladenin-9-yl)]-Co biosynthesis from adenosylcobinamide-GDP [+ 2 isozymes] HMPREF9701_RS28555 HMPREF9701_RS28555 [tRNA Trp ] HMPREF9701_RS23775 HMPREF9701_RS28575 methylmalonate- HMPREF9701_RS22205 3-enedioate β HMPREF9701_RS01415 adenine ribotide HMG-CoA -adenosylcobamide nicotinate adenine pantothenate kinase: trp ribose 5-phosphate semialdehyde L-tryptophan degradation phe RS11970 RS17745 benzimidazole 5-methoxy-6- adenosylcobinamide- phosphate fumarate acetoacetate 5'-phosphate dinucleotide HMPREF9701_RS24100 D-xylulose isomerase B: dehydrogenase I (via anthranilate) aspartate/tyrosine/ adenosylcobinamide- methylbenzimidazole hydroxymethylglutaryl- 6 ribotide GDP 5-phosphate (S)-3-amino-2- ditrans,octacis- ditrans,octacis- an O - (25S)-3- (4S)-4-hydroxy- a (3R)-3- an (11Z)-3- GDP NAD+ synthase: a 5,10- glutathione biosynthesis Secondary Metabolite Biosynthesis HMPREF9701_RS05865 (CoA acylating): CoA lyase: aromatic aminotransferase: a [protein]- 1-methyl-dAMP 2-oxoglutarate [DNA] a 3-oxotetracosanoyl- a 3-oxopimeloyl- NaMN methylglyoxal phosphate nicotinate-nucleotide-- NAD+ synthetase, (R)-4'- a 5-methyltetrahydrofolate a tRNA precursor exoribonuclease: methylpropanoate undecaprenyldiphospho- undecaprenyldiphospho- methylguanine oxocholest- coenzyme A a type IV prepilin 2-oxoglutarate hydroxydocosanoyl- oxooctadec- HMPREF9701_RS30440 methylenetetrahydrofolate 5-hydroxybenzimidazolyl adenosylcobamide HMPREF9701_RS17050 HMPREF9701_RS28670 L-cysteine [acp] [acp] methyl ester dIDP RS07195 dimethylbenzimidazole glutamine dependent: phosphopantothenate adenosylcobinamide- with a 5' extension HMPREF9701_RS01975 trp in DNA DNA oxidative exodeoxyribonuclease III: 4-en-26-oate 2-dehydro-3- [acp] 11-enoyl-[acp] 5'-nucleotidase: glyoxalase/bleomycin α α D-ribose 5- HMPREF9701_RS30820 N-acetyl-(N- N-acetyl-(N- bifunctional DNA-binding acyl-CoA synthetase: prepilin peptidase: NAD(P)-dependent 3-hydroxyacyl-[acyl- NAD(P)-dependent NAD(P)-dependent Co -[ -(2- adenosylcobinamide- NAD+ synthase: GDP ribazoletransferase: biosynthesis from adenosylcobinamide-GDP preQ biosynthesis and a long 3' trailer methylmalonate- [+ 3 isozymes] tryptophan 2,3- aspartate/tyrosine/ demethylase AlkB: HMPREF9701_RS08585 RS06140 phosphoribosyltransferase: heme a biosynthesis HMPREF9701_RS30440 methylenetetrahydrofolate cys glu thr 0 myo-inositol biosynthesis a tRNA precursor with acetylglucosaminyl) acetylglucosaminyl) HMPREF9701_RS31080 HMPREF9701_RS31290 HMPREF9701_RS10975 deoxyphosphogluconate oxidoreductase: carrier-protein] oxidoreductase: oxidoreductase: resistance/dioxygenase nucleoside- methyladenin-7-yl)]-Co GDP ribazoletransferase: HMPREF9701_RS10390 threonine--tRNA ligase: phosphate semialdehyde L-proline degradation aromatic aminotransferase: transcriptional regulator/ RS22110 HMPREF9701_RS01415 HMPREF9701_RS08495 a 5' extension and dioxygenase: muramoyl-L-alanyl-γ- muramoyl-L-alanyl-γ-D- HMPREF9701_RS17450 exodeoxyribonuclease III: acyl-CoA synthetase: aldolase/4-hydroxy-2- HMPREF9701_RS12545 HMPREF9701_RS12545 HMPREF9701_RS12545 bifunctional family protein: diphosphate kinase: β-adenosylcobamide reductase [NAD(P)H]: 5-hydroxybenzimidazole NaMN glutamate--cysteine ligase: RNase BN ribonuclease: acetoacetate HMPREF9701_RS09945 O6-methylguanine-DNA prepilin peptidase: dehydratase FabZ: HMPREF9701_RS08495 + HMPREF9701_RS06265 an L-threonyl- transketolase: dehydrogenase HMPREF9701_RS09950 5-methoxy-6- NAD HMPREF9701_RS07050 HMPREF9701_RS23015 D-glucopyranose a short 3' extension keto- D-isoglutaminyl-N-(β- isoglutaminyl-L-lysyl- HMPREF9701_RS07670 HMPREF9701_RS28085 HMPREF9701_RS25620 oxoglutarate aldolase: [+ 6 isozymes] HMPREF9701_RS30750 [+ 6 isozymes] [+ 6 isozymes] metallophosphatase/ HMPREF9701_RS03640 HMPREF9701_RS31210 ferroheme b Coα-[α-(adenin-9-yl)]- Thr HMPREF9701_RS30820 penicillin-binding protein 2: methyltransferase Ada: a 2'- (25S)-3- a (3R)-3- a (3R)-3- a (3R,11Z)-3- adenosylcobinamide- methylbenzimidazole 5-methoxybenzimidazolyl adenosylcobamide superpathway of heme [tRNA ] GTP 6-phosphate HMPREF9701_RS18130 (CoA acylating): tryptophan 2,3- phenylpyruvate di-trans,octa-cis succinate formaldehyde dAMP a cleaved type HMPREF9701_RS17345 a (2E)-docos- 5'-nucleotidase: [+ 3 isozymes] α α Thr ribonuclease P: D-asparaginyl)-L-lysyl- (glycyl) -D-alanyl-D-alanine Co -[ - protoheme IX Coβ-adenosylcobamide nicotinate-nucleotide-- γ-L-glutamyl-[+ 2 isozymes] a tRNA pro di-trans,octa-cis penicillin-binding protein 2: a peptidoglycan5 HMPREF9701_RS04650 HMPREF9701_RS09990 deoxyribonucleoside [DNA] oxocholest-4- a peptide hydroxytetracosanoyl- hydroxypimeloyl- hydroxyoctadec- GDP ribotide phosphate biosynthesis from adenosylcobinamide-GDP b biosynthesis from GTP cyclohydrolase [+ 2 isozymes] HMPREF9701_RS29500 HMPREF9701_RS12730 dioxygenase: D-alanyl-D-alaninea peptidoglycan -undecaprenyl a [protein]-S- IV prepilin pyruvate glyoxylate 2-enoyl-[acp] HMPREF9701_RS08690 (R)-lactate dITP RS22105 RS06160 (benzimidazolyl)]-Co farnesyltransferase: 5'-phosphate dimethylbenzimidazole delta-1-pyrroline- -undecaprenyl HMPREF9701_RS04650 dimer (S. aureus) a guanine in DNA 5'-monophosphate en-26-oyl-CoA [acp] [acp] methyl ester 11-enoyl-[acp] uroporphyrinogen-III L-cysteine a tRNA precursor dimer (E. faeciums) diphosphate methyl-L-cysteine β-D- β HMPREF9701_RS28990 phosphoribosyltransferase: I FolE2: D-sedoheptulose D-glyceraldehyde HMPREF9701_RS09995 5,6-dimethylbenzimidazole -adenosylcobamide adenosylcobinamide- 5-methoxybenzimidazole with a 5' extension a tRNA precursor with 5-carboxylate N-formylkynurenine diphosphate ribosylnicotinate RS06760 ferroheme o uroporphyrinogen-III HMPREF9701_RS01415 glutathione synthase: HMPREF9701_RS16830 Ins(3)P 7-phosphate hydrogencarbonate biosynthesis I (aerobic) 5'-phosphate GDP ribazoletransferase: menaquinol-7 biosynthesis 3-phosphate a short 3' extension dehydrogenase: lipoate biosynthesis and uroporphyrinogen HMPREF9701_RS29175 GTP cyclohydrolase I: phenylacetaldehyde nicotinate-nucleotide-- L-serine degradation HMPREF9701_RS19300 arylformamidase: HMPREF9701_RS08495 Coα-[α-(adenin-7-yl)]- all-trans- 5-hydroxybenzimidazole 7,8- HMPREF9701_RS11375 inositol monophosphatase: ribonuclease P: (S)-1-pyrroline- riboflavin incorporation III (Bacillus) decarboxylase: adenosylcobinamide-GDP ser transaldolase: ditrans,octacis- a 7,8-dihydro-8- a Chi-site containing a [pyruvate dehydrogenase a pseudouridine 1915 a 3- a (6Z)-3- (3R,5S)-3- RS04310 dimethylbenzimidazole 2-carboxy-1,4- ribotide phosphate glutathione dihydroneopterin 5-carboxylate HMPREF9701_RS09975 phenylacetaldehyde a glutaryl-[acp] a 3-oxoglutaryl- L-cysteate bifunctional riboflavin α α Coβ-adenosylcobamide HMPREF9701_RS22560 heptaprenyl serine--tRNA ligase: HMPREF9701_RS15635 HMPREF9701_RS08445 HMPREF9701_RS29500 a peptidoglycan with undecaprenyldiphospho- a malonyl-[acp] 1-methyl-dATP 2-oxoglutarate double stranded RecA E2 protein] N 6 - a protein MEP CTP oxooctadec- hydroxy-1- RS14950 Coα-[α- Co -[ -(5-methoxy-6- phosphoribosyltransferase: naphthoquinol 3'-triphosphate dehydrogenase: methyl ester oxoguanine in DNA in 23S rRNA demethyubiquinol [acp] methyl ester IDP coproporphyrinogen III diphosphate HMPREF9701_RS19495 an L-seryl- (L-alanyl-γ-D-glutamyl- N-acetyl-(N-acetyl-β-D- bifunctional DNA- DNA oxidative DNA with a blunt end dihydrolipoyl-L-lysine 23S rRNA bifunctional 2-polyprenyl-6- 6-enoyl-[acp] bifunctional aspartate pyrroline-5- kinase/FAD synthetase: (benzimidazolyl)]-Co methylbenzimidazolyl)]- an octanoyl-[acp] HMPREF9701_RS01415 ser beta-ketoacyl-[acyl-carrier- exodeoxyribonuclease V: dihydrolipoyl ATP-dependent 2-C-methyl-D- NAD(P)-dependent NAD(P)-dependent RS24385 ferroheme i adenosylcobinamide- ser 6-carboxytetrahydropterin myo-inositol D-erythrose L-glutamine L-kynurenine HMPREF9701_RS26565 HMPREF9701_RS11715 β Coβ-adenosylcobamide [tRNA ] threonine/serine L-lysyl-D-alanyl-D- glucosaminyl)muramoyl- protein] synthase I: formamidopyrimidine demethylase AlkB: HMPREF9701_RS22685 (pseudouridine(1915)-N(3) hydroxyphenol methylase/ Clp protease erythritol 4-phosphate oxidoreductase: oxidoreductase: aminotransferase/ carboxylate nucleoside- -adenosylcobamide lipoyl(octanoyl) transferase: 5-methoxybenzimidazole demethylmenaquinol-7 ser synthase: F6P an uncharged tRNA dehydrogenase: pyrroline-5- FMN GDP ribazoletransferase: a tRNA 4-phosphate degradation I aldehyde dehydrogenase alanine) pentapeptide L-alanyl-γ-D-glutamyl-L- glycosylase/DNA-(apurinic HMPREF9701_RS17450 )-methyltransferase RlmH: 3-demethylubiquinol 3-O- cytidylyltransferase: L-aspartate beta- 5'-phosphate HMPREF9701_RS07290 adenosylcobinamide-GDP HMPREF9701_RS12290 dehydratase: L-glutamate-5- HMPREF9701_RS24220 HMPREF9701_RS22690 HMPREF9701_RS26960 proteolytic subunit: HMPREF9701_RS12545 HMPREF9701_RS12545 carboxylate reductase: diphosphate kinase: RS20430 a [glycine-cleavage ribotide phosphate HMPREF9701_RS08495 kynureninase: (NAD(+)): lysyl-D-alanyl-D-alaninepenicillin-binding protein 2: or apyrimidinic site) lyase: HMPREF9701_RS27110 methyltransferase UbiG: decarboxylase: di-trans,poly-cis-undecaprenyl bifunctional transketolase: HMPREF9701_RS08845 [+ 2 isozymes] a double strandedHMPREF9701_RS22695 DNA an N 3 - HMPREF9701_RS22295 HMPREF9701_RS01575 [+ 6 isozymes] [+ 6 isozymes] HMPREF9701_RS31210 thr thr FMN reductase: complex H protein] lipoate biosynthesis 6-carboxy-5,6,7,8- semialdehyde HMPREF9701_RS09980 HMPREF9701_RS30475 a peptidoglycan with HMPREF9701_RS04650 succinate formaldehyde dATP [+ 2 isozymes] 4-(cytidine 5'- a (3R)-3- a (3R,6Z)-3- HMPREF9701_RS12925 RS28800 phosphate biosynthesis demethylmenaquinone HMPREF9701_RS18130 gln di-trans,octa-cis a 3-oxopimeloyl- HMPREF9701_RS11475 a [pyruvate dehydrogenase 1915 HMPREF9701_RS14825 HMPREF9701_RS28225 serine serine N 6 -octanoyl-L-lysine protoporphyrinogen IX and incorporation I threonine/serine (L-alanyl-γ-D-glutamyl- acyl-carrier protein with a RecA protein methylpseudouridine a peptide a peptide diphospho)-2-C- hydroxyglutaryl- hydroxyoctadec- HMPREF9701_RS19890 adenosylcobinamide- α α tetrahydropterin CTP delta-1-pyrroline- -undecaprenyl [acp] methyl ester an apurinic site 7,8-dihydro- 6 Hyp α α hydroxyferroheme i methyltransferase/2- Co -[ -(5-hydroxybenzimidazolyl)]- [+ 2 isozymes] dehydratase: phenylacetate L-lysyl-D-alanyl-D- loaded 3' overhang E2 protein] N -lipoyl-L-lysine in 23S rRNA UQH methyl-D-erythritol [+ 3 isozymes] ITP Co -[ -(5-methoxy-6- anthranilate 8-oxoguanine 2 [acp] methyl ester 6-enoyl-[acp] RS31285 [+ 4 isozymes] folate polyglutamylation GDP ribazoletransferase: (2E,6E)-farnesyl methoxy-6-polyprenyl- Coβ-adenosylcobamide 5'-phosphate 7-carboxy-7- D-glyceraldehyde synthase: pyrG 5-carboxylate diphosphate within DNA methyl-benzimidazolyl)]- IPP an octanoyl-[acp] pro 5-oxo-L-proline metabolism HMPREF9701_RS27080 alanine) pentapeptide 3-sulfopyruvate HMPREF9701_RS08495 diphosphate thioredoxin pathway deazaguanine synthase: [+ 5 isozymes] 2-aminoprop- dehydrogenase: RS21175 FMNH Coβ-adenosylcobamide di-trans,poly-cis- 1,4-benzoquinol proline--tRNA ligase: 3-phosphate L-methionine degradation a sugar RS03650 a sugar 2 lipoyl(octanoyl) transferase: HMPREF9701_RS12285 an N-terminal glu 2-enoate HMPREF9701_RS19300 a tetrahydrofolate a [lipoyl-carrier protein] decaprenylcistransferase: methylase UbiE: HMPREF9701_RS11215 an L-prolyl- I (to L-homocysteine) 6 α α an N-terminal L- 5,6-dimethylbenzimidazole N -octanoyl-L-lysine Co -[ -(5-methoxybenzimidazolyl)]- di-trans,octa-cisHMPREF9701_RS30785 HMPREF9701_RS11315 an oxidized HMPREF9701_RS07290 Pro 7-carboxy-7- L-glutaminyl- protoporphyrin IX a [lipoyl-carrier protein] [tRNA ] a ring-opened 7- adenosylcobinamide- adenine 1518 / a (3R)-3- a guanine 527 adenosine β α α Pro glutamyl-[protein] glu an L-cysteinyl- synthase: ferroheme a Co -adenosylcobamide 5'-phosphate Co -[ -(5-hydroxybenzimidazolyl) thioredoxin 6 deazaguanine [protein] a malonyl-[acp] a proteinogenic α-ribazole glycerophosphoglycerol (S)-dihydroorotate a cis-delta11-3- -undecaprenyl N -octanoyl-L-lysine a tRNA a malonyl-[acp] glutathione 1519 a myristoyl-[acp] hydroxyhexacosanoyl- 2',3'-cyclic KDO-8P his RS25915 bifunctional serine lipoyl synthase: ]-Coβ-adenosylcobamide met methylguanine in DNA methyl ester amino acid GDP adenine in 16S rRNA [tRNA Cys ] in 16S rRNA oxo-C30:1-[acp] a sugar RS18475 a sugar HMPREF9701_RS01335 diphosphate ferrochelatase: menaquinol-7 7-cyano-7-deazaguanine bifunctional DNA- adenosylcobinamide- 16S rRNA (adenine(1518)- glycerophosphoryl diester [acp] 16S rRNA dihydroorotase: monophosphate RS12070 tetrahydrofolate synthase/ hydroxymethyltransferase: glyA HMPREF9701_RS07295 bis(guanylyl molybdenum lipoyl synthase: L-arginine degradation methionine beta-ketoacyl-[acyl-carrier- gamma-glutamyltransferase: aminoacyl-tRNA hydrolase: 3-hydroxyacyl-[acyl- NAD(P)-dependent bifunctional 2',3'- 3-deoxy-D-manno- undecaprenyl- HMPREF9701_RS15335 synthase QueC: 2-iminopropanoate formamidopyrimidine beta-ketoacyl-[acyl-carrier- HMPREF9701_RS04085 L-histidine N(alpha) 5,6-dimethylbenzimidazole a [lipoyl-carrier protein] synthase I: HMPREF9701_RS04805 GDP ribazoletransferase: N(6)/adenine(1519)-N(6))- phosphodiesterase: HMPREF9701_RS11440 carrier-protein] (guanine(527)-N(7))- oxidoreductase: dihydrofolate synthase: [+ 2 isozymes] an N 10 - cofactor) biosynthesis thioredoxin- HMPREF9701_RS07295 VII (arginase 3 pathway) adenosyltransferase: protein] synthase I: cyclic-nucleotide 2'- octulosonate 8-phosphate -methyltransferase: 6 diphosphate phosphatase: NAD phosphorylation HMPREF9701_RS24305 glycosylase/DNA-(apurinic HMPREF9701_RS08495 dimethyltransferase RsmA: HMPREF9701_RS08360 methyltransferase RsmG: dihydroorotase: HMPREF9701_RS13495 protein]-N -[(R)- HMPREF9701_RS10440 HMPREF9701_RS24220 gamma-glutamyltransferase: aminoacyl-tRNA hydrolase: dehydratase FabZ: HMPREF9701_RS12545 phosphodiesterase/ phosphatase (KDO formyltetrahydrofolate Coα-[α-(5-methoxybenzimidazolyl) MoO - HMPREF9701_RS15760 ferroheme b disulfide reductase: a [lipoyl-carrier protein]-N 6 - a [protein] with HMPREF9701_RS24220 HMPREF9701_RS13190 2 and transhydrogenation superpathway of glycolysis and the Entner-Doudoroff pathway or apyrimidinic site) lyase: 6 HMPREF9701_RS293701518 [+ 2 isozymes] 7 HMPREF9701_RS29680 HMPREF9701_RS20545 a sugar RS09790 a sugar a 5,10- dihydrolipoyl]-L-lysine β phenylalanine--tRNA ligase: preQ an N-terminal 5- SAM [+ 2 isozymes] HMPREF9701_RS17830an α-(γ-L- N -dimethyladenine HMPREF9701_RS23495 HMPREF9701_RS30750 an N - a cis-delta11-3-[+ 6 isozymes] 3'-nucleotidase: 8-P phosphatase): bifunctional menaquinol-6 biosynthesis ]-Co -adenosylcobamide molybdopterin HMPREF9701_RS11810 [(R)-dihydrolipoyl]-L-lysine phe 0 γ-L-glutamyl arg HMPREF9701_RS11475 GMP adenosylcobalamin sn-glycerol a 3-oxohexadecanoyl- di-trans,octa-cis- HMPREF9701_RS06240 a 3-oxoglutaryl- 6 1519 Cys a (2E)-hexacos- 527 N-carbamoyl- RS19665 methylenetetrahydrofolate + oxo-L-proline glutathione 2,6-diamino-4- acyl-carrier protein L-cysteinylglycine glutamyl)-L- /N -dimethyladenine glycerol a tRNA cys methylguanine hydroxyC30:1- HMPREF9701_RS19540 HMPREF9701_RS29465 hercynine RS17725 a tetrahydrofolate tetrahydrofolate synthase/ cofactor bis(molybdenum undecaprenyl phosphate NAD D-glucopyranose 5-phosphate an apurinic site [acp] methyl ester 3-phosphate [acp] 2-enoyl-[acp] L-aspartate HMPREF9701_RS06245 an L-phenylalanyl- pyruvate hydroxy-5-(N-methyl) amino acid in 16S rRNA in 16S rRNA [acp] 3'-AMP Kdo bifunctional dihydrofolate synthase: cofactor) synthase: NAD kinase: 6-phosphate within DNA demethylmenaquinol-6 [tRNA Phe ] pyroglutamyl-peptidase I: arginase: formamidopyrimidine a purine RS04035 a purine tetrahydrofolate synthase/ HMPREF9701_RS13495 HMPREF9701_RS30495 a reduced bifunctional bis(molybdenum HMPREF9701_RS11520 a tRNA Phe HMPREF9701_RS08710 HMPREF9701_RS23255 dihydrofolate synthase: 10 menaquinol-9 biosynthesis menaquinol-8 biosynthesis + thioredoxin an N - demethylmenaquinone acyl carrier protein activation cofactor) NADP HMPREF9701_RS13495 SAH a [pyruvate dehydrogenase 966 guanosine RS19170 formyltetrahydrofolate molybdenum cofactor an [amino group carrier protein]-C- 1-(18-hydroxyoleoyl)- a (3R)-3- a guanine a (3R)-3- a protein methyltransferase/2- 16-hydroxypalmitate an acyl-[acyl- a 5-L-glutamyl- 6 a 3-oxohexacosanoyl- a cis-delta21-3- RS14130 octaprenyl diphosphate a 5,10- NAD(P) transhydrogenase: 5-oxo-L-proline urea a malonyl-[acp] an amino acid γ E2 protein] N -S- a lignoceroyl-[acp] hydroxytetracosanoyl- hydroxyicosanoyl- 2',3'-cyclic MEP with incorrect a purine RS17895 a purine methoxy-6-polyprenyl- demethylmenaquinol-9 an apo acyl- guanylyltransferase MobA: demethylmenaquinol-8 Hormone Biosynthesis glycine cleavage L-ornithine carrier protein] [peptide] terminal- -(L-glutamyl)-L-glutamate sn-glycrol 3-phosphate [acp] in 16S rRNA oxo-C40:1-[acp] coenzyme A 6 37 adenosylhomocysteinase: long-chain acyl- acetyldihydrolipoyl-L-lysine 16S rRNA monophosphate biosynthesis methylenetetrahydrofolate bifunctional carrier protein HMPREF9701_RS30495 bifunctional HMPREF9701_RS07680 N -L-threonylcarbamoyladenosine beta-ketoacyl-[acyl-carrier- gamma-glutamyltransferase: NAD(P)-dependent [acp] 3-hydroxyacyl-[acyl- [acp] 3-hydroxyacyl-[acyl- NAD(P)-dependent bifunctional 2',3'- 1-deoxy-D-xylulose- disulfide bonds 1,4-benzoquinol holo-ACP synthase: acetylglutamate kinase: dihydrolipoyllysine- 1-acyl-sn-glycerol-3- beta-ketoacyl-[acyl-carrier- HMPREF9701_RS07685 -modified tRNA biosynthesis 5-oxoprolinase: a [glycine- HMPREF9701_RS07060 CoA synthetase: protein] synthase II: HMPREF9701_RS04805 oxidoreductase: (guanine(966)-N(2))- oxidoreductase: 5-phosphate (2E,6E)-farnesyl methylase UbiE: demethylmenaquinone bis(guanylyl demethylmenaquinone met indole-3-acetate glucose-6-phosphate ornithine cyclodeaminase: residue acetyltransferase: phosphate acyltransferase: carrier-protein] carrier-protein] cyclic-nucleotide 2'- HMPREF9701_RS03335 methionine--tRNA ligase: indole-3-acetate HMPREF9701_RS08705 cleavage complex HMPREF9701_RS04965 HMPREF9701_RS03390 HMPREF9701_RS23985 protein] synthase I: methyltransferase RsmD: HMPREF9701_RS12545 reductoisomerase: RS20165 IPP HMPREF9701_RS11315 methyltransferase/2- molybdopterin methyltransferase/2- NADPH an L-methionyl- biosynthesis III (bacteria) isomerase: HMPREF9701_RS10040 gamma-glutamyltransferase: HMPREF9701_RS04080 HMPREF9701_RS12545 dehydratase FabZ: dehydratase FabZ: phosphodiesterase/ a purine RS27465 a purine diphosphate 4'-phosphopantetheinyl HMPREF9701_RS12255 biosynthesis IV (bacteria) H protein] N 6 - an [amino group carrier protein]- HMPREF9701_RS28535 HMPREF9701_RS24220 HMPREF9701_RS12460 octaprenyl- methoxy-6-polyprenyl- cofactor) methoxy-6-polyprenyl- glycine dehydrogenase L-homocysteine [+ 10 isozymes] [+ 2 isozymes] HMPREF9701_RS17830 a [pyruvate dehydrogenase 1-[18-hydroxyoeoyl]-2- [+ 6 isozymes] HMPREF9701_RS30750 an N 2 - HMPREF9701_RS30750 [+ 6 isozymes] 3'-nucleotidase: HMPREF9701_RS30775 a protein menaquinol-6 [elongator HMPREF9701_RS10470 thr ornithine cyclodeaminase: an α-(5-L- γ a (3R)-3- a cis-delta21-3- 1-deoxy-D- RS15605 diphosphate synthase: transferase: glu lipoyl-L-lysine (aminomethyl-transferring) C-terminal- -(5-phospho- 6 a 3-oxohexacosanoyl- a (2E)-tetracos- 966 a (2E)-icos- 1,4-benzoquinol 1,4-benzoquinol elongator Met (indole-3-yl) HMPREF9701_RS23260 16-hydroxypalmitoyl- E2 protein] N - [18-hydroxy-lioleoyl]-sn methylguanine HMPREF9701_RS19540 xylulose 5- with correct tRNA ] trp glucose-6-phosphate threonylcarbamoyl- AMP diphosphate acyl-carrier protein a 3-oxoacyl-[acp] a peptide glutamyl)- hydroxyhexacosanoyl- hydroxyC40:1- HMPREF9701_RS11185 methylase UbiE: HMPREF9701_RS25555 methylase UbiE: Met 6-phospho gcv system: : HMPREF9701_RS21710 L-aspartate degradation I L-glutamyl)-L-glutamate dihydrolipoyl-L-lysine -glycerol 3-phosphate [acp] 2-enoyl-[acp] 2-enoyl-[acp] all-trans-octaprenyl a holo acyl- tRNA acetonitrile isomerase: AMP synthase: CoA amino acid [acp] in 16S rRNA [acp] 3'-GMP phosphate disulfide bonds Ni 2+ Ni 2+ 3',5'-ADP D-glucono- pro RS08425 diphosphate HMPREF9701_RS11315 carrier protein HMPREF9701_RS11315 HMPREF9701_RS08440 HMPREF9701_RS12770 HMPREF9701_RS21710 Peptide Peptide RS23725 1,5-lactone menaquinol-9 menaquinol-8 (indol-3-yl) (indol-3-yl) [+ 3 isozymes] asp threonylcarbamoyl- a [glycine- acetamide acetamide a [glycine-cleavage L-asparagine RS06305 AMP synthase: bifunctional aspartate 2-chloro-trans a DNA with DNA with adenine:7,8- a 3,5,7,9,11,13,15- a cytidine 1402 a (3R)-3- (R)-4-hydroxy- cleavage complex 6 a (4Z)-hexadec- a cis-delta19-3- sn-glycerol 3'-cmp 2+ 2+ Lys complex H protein] N - degradation I 18-hydroxystearate folate Ni Ni a tRNA amidase: amidase: HMPREF9701_RS11570 6 aminotransferase/ a palmitoleoyl-[acp] a malonyl-[acp] a malonyl-[acp] -dienelactone hypoxanthine dihydro-8- a dodecanoyl-[acp] hepta-oxo- in 16S rRNA hydroxypimeloyl- 4-methyl-2- RS11410 lysine--tRNA ligase: (L-threonylcarbamoyl) H protein] N - 4-enoyl-[acp] oxo-C38:1-[acp] 3-phosphate Peptide Peptide HMPREF9701_RS20375 HMPREF9701_RS20375 D-gluconate aminomethyldihydrolipoyl- L-aspartate beta- long-chain acyl- beta-ketoacyl-[acyl-carrier- beta-ketoacyl-[acyl-carrier- carboxymethylenebutenolidase: DNA-deoxyinosine oxoguanine mismatchA/G-specific adenine hexadecanoyl-[PKS-acp] glutamate 16S rRNA [acp] methyl ester NAD(P)-dependent oxoglutarate bifunctional 2',3'- RS09385 Fatty Acid and Lipid Biosynthesis HMPREF9701_RS03290 adenylate dihydrolipoyl- L-phenylalanine degradation I (aerobic) 3-hydroxyacyl-[acyl- 4-carboxy-4-hydroxy- glycerol-3-phosphate 1- an L-lysyl- [+ 3 isozymes] 6-phosphate L-lysine asn CoA synthetase: HMPREF9701_RS12520 glycosylase: beta-ketoacyl-[acyl-carrier- aldo/keto reductase: carboxypeptidase: (cytosine(1402)-N(4))- cyclic-nucleotide 2'- [+ 3 isozymes] 6 L-lysine decarboxylase: protein] synthase I: protein] synthase I: glycosylase: carrier-protein] oxidoreductase: 2-oxoadipate Lys N -L- protein] synthase I: HMPREF9701_RS22825 O-acyltransferase PlsY: [tRNA ] phosphogluconate asparaginase: HMPREF9701_RS28225 HMPREF9701_RS04965 HMPREF9701_RS24220 HMPREF9701_RS24220 carboxymethylenebutenolidase: HMPREF9701_RS11645 HMPREF9701_RS11485 HMPREF9701_RS20490 methyltransferase RsmH: HMPREF9701_RS12545 phosphodiesterase/ threonylcarbamoyladenine (6R)-4a-hydroxy- dehydratase FabZ: aldolase/oxaloacetate HMPREF9701_RS13410 2+ 2+ palmitate biosynthesis II (bacteria and plants) lys (indol-3-yl)acetate (indol-3-yl)acetate F6P HMPREF9701_RS22550 HMPREF9701_RS24220 [+ 4 isozymes] HMPREF9701_RS04660 3'-nucleotidase: Ni Ni RS01085 dehydratase: [+ 10 isozymes] HMPREF9701_RS12025 9-hydroxy-3,5,7,11,13,15- [+ 2 isozymes] an N 4 - decarboxylase: 1-oleoyl-sn RS22750 oleate biosynthesis (5Z)-dodecenoate biosynthesis I fatty acid elongation -- saturated synthase: tetrahydrobiopterin 4a-hydroxytetrahydrobiopterin [+ 3 isozymes] [+ 2 anisozymes] (11Z)-3- [+ 2 isozymes]a (6Z)-3- hypoxanthine an apurinic site adenine an apurinic site a (2E)- HMPREF9701_RS30750 a cis-delta19-3-[+ 6 isozymes] Peptide Peptide superpathway of guanosine Nucleoside and Nucleotide Biosynthesis HMPREF9701_RS17340 aminomethyltransferase: [+ 2 isozymes] a 3-oxotetradecanoyl- 1402 HMPREF9701_RS19540 IV (anaerobic) inosine-5'-phosphate biosynthesis I fructose 1,6- HMPREF9701_RS15880 dehydratase: oxaloacetate 18-hydroxystearoyl- acyl-carrier protein oxooctadec- acyl-carrier protein 2-chloromaleylacetate within DNA within DNA hexaoxohexadecanoyl- glutamate pteroate methylcytidine enoylpimeloyl- hydroxyC38:1- HMPREF9701_RS22860 -glycerol 3- RS10515 nucleotides de novo biosynthesis I superpathway of superpathway of pyrimidine superpathway of 5-aminoimidazole pyrimidine CMP phosphorylation phenylalanine 4- asp AMP diphosphate oxooctadec- [acp] cytidine a (3R)-3- 6-phosphofructokinase: 6 HMPREF9701_RS21710 HMPREF9701_RS11940 CoA [PKS-acp] in 16S rRNA phosphate an acetoacetyl-[acp] a (3R)-3- adenosine nucleotides nucleobases salvage ribonucleotide biosynthesis nucleobases salvage II bisphosphatase: an N -L- 11-enoyl-[acp] 6-enoyl-[acp] [acp] methyl ester [acp] pyruvate hydroxydecanoyl- an acetoacetyl-[acp] KDGP HMPREF9701_RS03325 37 monooxygenase: de novo biosynthesis I HMPREF9701_RS25305 threonylcarbamoyladenine Ni 2+ Ni 2+ hydroxydodecanoyl- [acp] bifunctional 3- AIR uracil cytosine CMP HMPREF9701_RS24255 RS24395 NAD(P)-dependent IMP his β-D-fructose 1,6- in tRNA Peptide Peptide [acp] 3-hydroxyacyl-[acyl- hydroxydecanoyl-ACP bifunctional pyr operon PRPP cytosine deaminase: bifunctional 3- histidine--tRNA ligase: RS31660 oxidoreductase: 5-(carboxyamino)imidazole DHAP N-end rule pathway I (prokaryotic) (6R)-L-erythro-5,6,7,8- L-erythro-7,8- a reduced L-alanyl-γ-D- 4-(cytidine 5'- 1-palmitoyl- a (3R)-3- a [lipoyl-carrier carrier-protein] dehydratase/trans-2- IMP asp amidophosphoribosyltransferase: phosphoshikimate 1- HMPREF9701_RS31185 2-dehydro-3- bisphosphate L-alanyl-γ-D-glutamyl- an N-modified 3-oxo-(7Z)- 3'-UMP RS00320 transcriptional regulator/uracil HMPREF9701_RS31065 an L-histidyl- UDP-N-acetyl-α-D-muramate a cis-delta17-3- 6 histidinol HMPREF9701_RS12545 dehydratase FabZ: ribonucleotide synthase: carboxyvinyltransferase/ deoxyphosphogluconate tetrahydrobiopterin dihydrobiopterin electron-transfer ubiquinone-6 hexadecenoyl-CoA 3'-dephospho- glutamyl-meso-2,6- a behenoyl-[acp] an arachidoyl-[acp] diphospho)-2-C- sn-glycerol hydroxyglutaryl- protein]-N -[(R) decenoyl-ACP isomerase: adenylosuccinate synthase: phosphoribosyltransferase HMPREF9701_RS13510 uracil [tRNA His ] fructose-bisphosphate leucyl/phenylalanyl-tRNA- meso-diaminopimelate aminoacyl-[tRNA] ATP oxo-C36:1-[acp] [+ 6 isozymes] IMP dehydrogenase: HMPREF9701_RS12775 5-phospho-β- acetyl-CoA C- CoA methyl-D-erythritol 3-phosphate bifunctional 2',3'- HMPREF9701_RS30750 cytidylate kinase: His aldolase/4-hydroxy-2- aldolase class II: triose-phosphate UDP-N-acetylmuramate:L- flavoprotein aminoacyl-tRNA hydrolase: diaminopimeloyl- 4-(cytidine 5'- [acp] methyl ester NAD(P)-dependent -dihydrolipoyl]- predicted a (2E)-dodec- HMPREF9701_RS24225 HMPREF9701_RS09270 HMPREF9701_RS31140 PyrR: HMPREF9701_RS04095 a tRNA -protein transferase: electron transfer beta-ketoacyl-[acyl-carrier- beta-ketoacyl-[acyl-carrier- 1-acyl-sn-glycerol-3- 3-hydroxyacyl-[acyl- histidinol dehydrogenase: a 3-oxoacyl-[acp] adenylo-succinate D-ribosylamine bifunctional pyr operon HMPREF9701_RS14855 oxoglutarate aldolase: isomerase: a [protein] alanyl-gamma-D- acyltransferase: dephospho-CoA kinase: D-alanine muramoyltetrapeptide oxidoreductase: L-lysine dihydrolipoyl cyclic-nucleotide 2'- 2-enoyl-[acp] N5-CAIR HMPREF9701_RS18145 HMPREF9701_RS30355 Aromatic Compound Degradation flavoprotein-ubiquinone HMPREF9701_RS11440 diphospho)-2-C-methyl- carrier-protein] ATP-driven a (3R)-3-hydroxybutanoyl-[acp] 3-hydroxyacyl-[acyl- uracil transcriptional regulator/uracil an N-terminal protein] synthase I: protein] synthase I: phosphate acyltransferase: HMPREF9701_RS10835 phosphodiesterase/ K + K + phosphoribosylamine- CDP HMPREF9701_RS17345 HMPREF9701_RS02960 N-terminal L- glutamyl- meso- HMPREF9701_RS20590 HMPREF9701_RS10970 carboxypeptidase: D-erythritol kinase: dehydratase FabZ: HMPREF9701_RS12545 dehydrogenase: transporter arginyl-[protein] oxidoreductase: aminoacyl-tRNA hydrolase: HMPREF9701_RS24220 HMPREF9701_RS24220 HMPREF9701_RS04080 RS24295 RS24435 bifunctional 3- carrier-protein] XMP adenylosuccinate lyase: phosphoribosyltransferase: -glycine ligase: phosphoribosyltransferase leucyl-L-arginine diaminopimelate ligase: [+ 8 isozymes] L-alanyl-HMPREF9701_RS13325γ-D- HMPREF9701_RS28530 3'-nucleotidase: nucleoside- HMPREF9701_RS21620an oxidized HMPREF9701_RS23495 + a 3- 2-phospho-4-(cytidineHMPREF9701_RS11460 1-palmitoyl- a (2E)- HMPREF9701_RS30750 a cis-delta17-3-[+ 6 isozymes] of K+ 3-hydroxyacyl-[acyl-carrier- hydroxydecanoyl-ACP dehydratase FabZ: HMPREF9701_RS14205 HMPREF9701_RS27075 PyrR: HMPREF9701_RS04095 protocatechuate degradation an uncharged (5Z)- ADP coenzyme A H D-ala glutamyl-meso- a 3-oxotetracosanoyl- his HMPREF9701_RS19540 HMPREF9701_RS27095 D-glyceraldehyde 4-hydroxyphenylacetate degradation HMPREF9701_RS04520 + an N-modified acetyl-CoA 2-myristoyl a [lipoyl-carrier[+ 2 isozymes] protein] dehydratase FabZ: pyrimidine deoxyribonucleotides de novo biosynthesis I diphosphate kinase: 3,5-dichlorocatechol degradation catechol degradation III α H ubiquinol-6 electron-transfer oxodocosanoyl- 5'-diphospho)-2-C- enoylglutaryl- hydroxyC36:1- dehydratase/trans-2- HMPREF9701_RS30750 UMP uracil glycine--tRNA ligase: 3-phosphate I (meta-cleavage pathway) UDP-N-acetyl- -D-muramoyl-L-alanyl- amino acid tRNA tetradecenoyl-CoA diaminopimelate [acp] protein]-N 6 - uridine a (2E)-dec- HMPREF9701_RS31210 gly leucyl/phenylalanyl-tRNA- (ortho-cleavage pathway) γ flavoprotein [acp] methyl-D-erythritol phosphatidate [acp] methyl ester [acp] K(+)- HMPREF9701_RS30750 decenoyl-ACP isomerase: GMP synthase: asp GAR phosphoribosyltransferase: HMPREF9701_RS24145 -D-glutamyl-meso-2,6-diaminopimelate lipoyl-L-lysine 2-enoyl-[acp] CAIR AMP UDP CTP bifunctional 3- glyceraldehyde-3- -protein transferase: (4-hydroxyphenyl)acetate K + transporting K + HMPREF9701_RS24225 3-ketoacyl-ACP reductase: HMPREF9701_RS17150 HMPREF9701_RS27075 CTP HMPREF9701_RS24150 a [protein] protocatechuate 3,5-dichlorocatechol phosphoshikimate 1- phosphoribosylglycinamide Gly phosphate dehydrogenase: HMPREF9701_RS30355 catechol RS03375 RS02930 a (2E)-but-2-enoyl-[acp] bifunctional 3- beta-ketoacyl-[acyl-carrier- HMPREF9701_RS21550 ribonucleoside- a glycyl-[tRNA ] an N-terminal N-terminal L- protocatechuate 4-hydroxyphenylacetate- ATPase a (3Z)-dodec- carboxyvinyltransferase/ formyltransferase: HMPREF9701_RS18125 catechol 1,2-dioxygenase: an N 6 -L- (5E)-3-oxo- 1-palmitoyl- a phosphorylated hydroxydecanoyl-ACP protein] synthase II: phosphoribosylaminoimidazolesuccinocarboxamide diphosphate reductase: UMP Gly L-lysyl-[protein] 4,5-dioxygenase: 3-monooxygenase 3-oxo-(9Z)- a 1-acyl-sn-glycerol (2R,3S)-2- a nucleoside [+ 6 isozymes] adenylate kinase: CDP a tRNA leucyl-L-lysine a peptidoglycan 37 2,3-DHP an isocitrate 3-enoyl-[acp] GMP HMPREF9701_RS04470 cytidylate kinase: HMPREF9701_RS03310 large chain: 2,4-dichloro- superpathway of HMPREF9701_RS12145 a palmitoyl-[acp] a malonyl-[acp] threonylcarbamoyladenine octadecenoyl-CoA dodec-5- a stearoyl-[acp] sn-glycerol isocitrate crotonyl-[acyl-carrier- dehydratase/trans-2- HMPREF9701_RS03390 synthase: HMPREF9701_RS12835 HMPREF9701_RS22845 3-phosphate GTP H O dehydrogenase methylisocitrate diphosphate GTP 3+ 3+ HMPREF9701_RS16495 HMPREF9701_RS14855 13-DPG salicylate degradation lysozyme: 2 enoyl-CoA Fe RS05015 Fe HMPREF9701_RS04475 Electron Transfer HMPREF9701_RS05580 cis,cis-muconate catechol 1,2-dioxygenase: beta-ketoacyl-[acyl-carrier- in tRNA tRNA acetyl-CoA C- 2,3-dihydroxyphenylpropionate 3-phosphate bifunctional isocitrate dehydrogenasebifunctional isocitrate bifunctional aconitate protein] reductase: fabG beta-ketoacyl-[acyl-carrier- decenoyl-ACP isomerase: [+ 2 isozymes] a (3R)-3- ribonucleoside- FGAR HMPREF9701_RS22850 HMPREF9701_RS00125 1-acyl-sn-glycerol-3- GTPase Era: acetyl-CoA C- beta-ketoacyl-[acyl-carrier- 1-acyl-sn-glycerol-3- nucleoside- a 2,3,4-saturated [+ 2 isozymes] UMP kinase: 3,4-dihydroxyphenylacetate HMPREF9701_RS05130 protein] synthase I: threonylcarbamoyladenosine acyltransferase: 1,2-dioxygenase: dehydrogenase dehydrogenase hydratase 2/2- RS00345 protein] synthase II: HMPREF9701_RS24225 hydroxyacyl-[acyl- guanylate kinase: diphosphate reductase, [+ 3 isozymes] phosphate acyltransferase: HMPREF9701_RS03350 acyltransferase: protein] synthase I: phosphate acyltransferase: diphosphate kinase: fatty acyl-[acp] SAICAR ADP dUDP HMPREF9701_RS30795 phosphoglycerate kinase: salicylate cis,cis-muconate HMPREF9701_RS24220 lysozyme: HMPREF9701_RS20590 methylisocitrate RS02905 a butanoyl-[acp] HMPREF9701_RS03390 carrier protein] HMPREF9701_RS22165 adenosylcobalamin- phosphoribosylformylglycinamidine ATP biosynthesis HCMS dehydratase: HMPREF9701_RS29970 HMPREF9701_RS04080 HMPREF9701_RS20325 kinase/phosphatase: kinase/phosphatase: HMPREF9701_RS31210 a (3Z)-dec- 3-hydroxyacyl-[acyl- salicylate hydroxylase: [+ 4 isozymes] HMPREF9701_RS24220 HMPREF9701_RS04080 3+ 3+ HMPREF9701_RS14085 Respiration HMPREF9701_RS02190 6 [+ 8 isozymes] (2Z,4E)-2-hydroxy- dehydratase: Fe RS24175 Fe [+ 2 isozymes] nucleoside- dependent: UDP synthase: HMPREF9701_RS27480 met 2,4-dichloro- [+ 2 isozymes] a N-acetylmuramoyl- a cyclic N -L-HMPREF9701_RS26790 [+ 8 isozymes] 1-palmitoyl-2- a phosphorylatedHMPREF9701_RS19065 HMPREF9701_RS19065 3-enoyl-[acp] carrier-protein] adenylosuccinate lyase: methionine--tRNA ligase: HMPREF9701_RS18610 muconate cycloisomerase: (7Z)- 6-oxonona-2,4- a 1-acyl-2-palmitoyl-sn phosphate GDP H + a 3-oxoicosanoyl- an isocitrate HMPREF9701_RS20080 a nucleoside beta-ketoacyl-[acyl-carrier- a (5Z)-3-oxo- ribonucleoside- HMPREF9701_RS24985 3-phospho- a 3-oxooctadecanoyl- N-acetyl-D- threonylcarbamoyladenosine acetyl-CoA (3E)-dec-3- cis-vaccenoyl cyclic-GMP dehydratase FabZ: HMPREF9701_RS14205 diphosphate kinase: nucleoside- 2,5-dihydro-5- acyl-carrier protein pentapeptide- hexadecenoyl-CoA -glycerol 3-phosphate acetyl-CoA isocitrate cis-2- triphosphate tetradec-5- beta-ketoacyl-[acyl-carrier- GDP diphosphate reductase: HMPREF9701_RS12255 an L-methionyl- D-glycerate 2-oxoglutarate decarboxylation to succinyl-CoA 2-hydroxy-5- salicylate hydroxylase: HMPREF9701_RS12130 [acp] glucosamine diene-1,9-dioate enoyl-CoA [acp] phosphatidate dehydrogenase protein] synthase I: HMPREF9701_RS31210 ribonucleoside- FGAM ADP oxofuran-2-acetate diphosphoundecaprenol 37 in tRNA dehydrogenase methylaconitate RS11595 protein] synthase II: HMPREF9701_RS30750 diphosphate kinase: [initiator tRNA Met ] carboxymethylmuconate HMPREF9701_RS10005 HMPREF9701_RS24220 enoyl-[acp] HMPREF9701_RS04470 2-hydroxy-4- 3+ 3+ AICAR diphosphate reductase: Met phosphoglycerate catechol (+)-muconolactone Fe RS29340 Fe 3-oxoacyl- HMPREF9701_RS03390 dUTP HMPREF9701_RS31210 initiator tRNA F0F1 ATP synthase: a [2-oxoglutarate semialdehyde RS12855 RS04935 [+ 2 isozymes] HMPREF9701_RS04475 HMPREF9701_RS04470 phosphoribosylformylglycinamidine mutase: gpmA carboxymuconate RS10110 HMPREF9701_RS07240 dehydrogenase 3-[(3aS,4S,7aS)-7a-methyl- an [RNA]-3'- cytidine 2',3'-cyclic ACP [+ 2 isozymes] nucleoside- ribonucleoside- bifunctional [+ 2 isozymes] dUTP diphosphatase: UTP cyclo-ligase: HMPREF9701_RS09865 semialdehyde 5-carboxymethyl-2- catechol 1,2-dioxygenase: muconolactone 2-amino-6-[1-hydroxyethyl]- 4-hydroxybenzoyl- 3-oxopentanoyl- a (3R,6Z)-3- 5-deoxy-D- HMPREF9701_RS04475 HMPREF9701_RS07245 6 2-oxoglutarate acetyl-CoA 1-cis-vaccenoyl-sn- a cis-delta15-3- reductase a (5Z)-3- diphosphate kinase: 2-phospho- E2 protein] N hydroxymuconate 2-chloro-trans delta-isomerase: an acetyl-[acp] a malonyl-[acp] 1,5-dioxo-octahydro-1H coenzyme A trans-dienelactone an octanoyl-[acp] ribonucleoside- monophosphate hydroxyoctadec- a 3-oxohexanoyl-[acp] diphosphate reductase: phosphoribosylaminoimidazolecarboxamide HMPREF9701_RS02565 dehydrogenase hemiacetal HMPREF9701_RS12145 7-methyl-7,8-dihydropterin CoA CoA glycerol-3-phosphate adenine PRPP oxo-C34:1-[acp] glucuronate ATP oxododec- dCDP HMPREF9701_RS07250 D-glycerate -lipoyl-L-lysine -inden-4-yl]propanoate carboxymethylenebutenolidase: acetyl-CoA C- acetyl-CoA C- 3'-phosphate bifunctional 2',3'- 3+ 3+ RS07335 FabG: fabG HMPREF9701_RS31210 HMPREF9701_RS04470 formyltransferase/IMP cyclohydrolase dADP CTP synthase: pyrG AIR pyrimidine deoxyribonucleotide phosphorylation 2-hydroxy-4- semialdehyde -dienelactone HMPREF9701_RS12135 beta-ketoacyl-[acyl-carrier- acyl-CoA synthetase: 2-amino-4-hydroxy-6- 6-enoyl-[acp]3-hydroxyacyl-[acyl- NAD(P)-dependent 5-deoxy-glucuronate Fe RS23145 Fe 5-enoyl-[acp] dUMP HMPREF9701_RS07255 E1 component: catechol 1,2-dioxygenase: 1-acyl-sn-glycerol-3- adenine beta-ketoacyl-[acyl-carrier- RNA 3'-terminal cyclic-nucleotide 2'- NAD(P)-dependent [+ 5 isozymes] a trans-2- HMPREF9701_RS04475 PurH: HMPREF9701_RS04160 nucleoside- phosphopyruvate 2-oxoglutarate carboxymuconate- dehydrogenase: (4,5-dihydro- protein] synthase I: HMPREF9701_RS31290 hydroxymethyldihydropteridine HMPREF9701_RS12520 acyltransferase: acetyltransferase: oxidoreductase: a 2,3,4-saturated 2,3,4-saturated-fatty- HMPREF9701_RS07260 HMPREF9701_RS26950 HMPREF9701_RS05130 phosphate acyltransferase: phosphoribosyltransferase: protein] synthase I: phosphodiesterase/ carrier-protein] isomerase: a (3R,5Z)-3- 3-oxoacyl- enoyl-[acyl- thymidylate synthase: CTP dTMP dCMP hydratase: HMPREF9701_RS29985 5-oxofuran- diphosphokinase: carboxymethylenebutenolidase: HMPREF9701_RS20325 HMPREF9701_RS16650 phosphate cyclase: RS08815 oxidoreductase: acid-[acp] reductase: [+ 2 isozymes] nucleoside- diphosphate kinase: Carbohydrate Biosynthesis dehydrogenase 6-semialdehyde HMPREF9701_RS24220 acyl-CoA synthetase: HMPREF9701_RS04080 dehydratase FabZ: HMPREF9701_RS12545 HMPREF9701_RS12750 RS08550 RS06920 hydroxy-tetradec- ACP fatty acyl-[acp] FAICAR HMPREF9701_RS30925 dTMP kinase: bifunctional 3- HMPREF9701_RS07265 HMPREF9701_RS26595 alpha-ketoglutarate HMPREF9701_RS29475 HMPREF9701_RS24220 HMPREF9701_RS23250 3'-nucleotidase: HMPREF9701_RS12545 carrier protein] GTP diphosphate kinase: HMPREF9701_RS31210 E1 component: dehydrogenase: 5-carboxymethyl-2- cis,cis-muconate 2-yl)-acetate [+ 2 isozymes] 3-[(3aS,4S,7aS)-7a-methyl-HMPREF9701_RS28085 [1-(2-amino-7-methyl-4-oxo-HMPREF9701_RS09845 HMPREF9701_RS12025 [+ 8 isozymes] [+ 10 isozymes] 1-cis-vaccenoyl- an [RNA]-3'- HMPREF9701_RS30750 [+ 6 isozymes] 5-dehydro- a cyclic a cyclic reductase HMPREF9701_RS23720 HMPREF9701_RS07270 dehydrogenase: 2-chloro-cis- 4-hydroxybenzoyl- AMP HMPREF9701_RS19540 a (2E,6Z)- a cis-delta15-3- RS01700 [+ 6 isozymes] 5-enoyl-[acp] HMPREF9701_RS31210 dTMP HMPREF9701_RS26745 phosphoshikimate 1- phosphopyruvate HMPREF9701_RS26950 HMPREF9701_RS22840 hydroxymuconate 3-oxoadipate 2-maleylacetate propanoyl-CoA acetyl-CoA 2-palmitoleoyl-sn- a 3-oxodecanoyl- 2-deoxy-D- peptide peptide RS07135 bifunctional dCTP gluconeogenesis I HMPREF9701_RS07275 an acetoacetyl-[acp] acyl-carrier protein 1,5-dioxo-octahydro-1H- 7,8-dihydro-3H-pteridin- acetyl-CoA ribonucleoside-2',3'- octadecadienoyl- hydroxyC34:1- cyclic-AMP 3-hydroxyacyl-[acyl- FabG: fabG dTDP carboxyvinyltransferase/ GDP-mannose biosynthesis HMPREF9701_RS23470 dienelactone muconate cycloisomerase: enol-lactonase: [acp] 3'-cmp gluconate dGDP phosphoribosylaminoimidazolecarboxamide dTMP kinase: UDP-α-D-glucose biosynthesis I hydratase: [+ 4 isozymes] 2-pyrone-4,6- 5-carboxymethyl-2- inden-4-yl]propanoyl-CoA 6-yl)]ethyl diphosphate glycerol-3-phosphate cyclophosphate [acp] [acp] a (3R)-3-hydroxyhexanoyl-[acp] carrier-protein] [+ 5 isozymes] cytidylate kinase: HMPREF9701_RS07280 carboxymethylenebutenolidase: HMPREF9701_RS12130 HMPREF9701_RS19370 formyltransferase/IMP cyclohydrolase dATP HMPREF9701_RS26745 nucleoside- HMPREF9701_RS02595 a [2-oxoglutarate a [2-oxoglutarate dicarboxylate hydroxymuconate dehydratase FabZ: a (3R,5Z)-3- HMPREF9701_RS14855 (S)-malate D-glucopyranose ATP HMPREF9701_RS12520 diphosphate kinase: D-glucopyranose phosphoenol dehydrogenase dehydrogenase isomerase: a cyclic a cyclic RS08480 HMPREF9701_RS30750 hydroxydodec- gondoate biosynthesis nucleoside- PurH: HMPREF9701_RS04160 2-pyrone-4,6- (+)-muconolactone 3-oxoadipate RS23130 RS20480 3-hydroxyacyl-[acyl-carrier- dTDP HMPREF9701_RS31210 dCDP 6-phosphate 6-phosphate 6 6 carboxymethylenebutenolidase: a [2-oxoglutarate- 2-phospho-4-(cytidine 5'- 3-oxo-(9Z)- 6-trans-3-oxo- 4-trans-3-oxo- 1,6-anhydro-N- adenine 2030 a (3R,11Z)-3- peptide peptide RS16390 5-enoyl-[acp] diphosphate kinase: phosphomannomutase/ glucose-6-phosphate pyruvate E2 protein] N E2 protein] N -S- dicarboxylate hydrolase: HMPREF9701_RS12315 1-myristoyl-sn- a cis-delta13-3- a [protein]- protein] dehydratase FabZ: a (2E,5Z)- (anaerobic) HMPREF9701_RS12025 dehydrogenase a sulfurated glutathione hypoglycin A diphospho)-2-C-methyl-D-erythritol sn-glycerol 3-phosphate a butanoyl-[acp] hydroxyoctadec- digallate nucleoside- nucleoside- NADP-dependent malate dehydrogenase, isomerase: -dihydrolipoyl- succinyldihydrolipoyl- muconolactone 3-oxoadipate SAM hexadecenoyl-CoA tridecenoyl-CoA undecenoyl-CoA glycerol 3-phosphate acetyl-β-muramate in 23S rRNA L-histidine tetradeca-2,5- 3-hydroxyacyl-[acyl- HMPREF9701_RS31210 dTTP phosphoglucomutase: phosphoenolpyruvate HMPREF9701_RS22855 5-carboxymethyl-2- 6 2-C-methyl-D-erythritol oxo-C32:1-[acp] HMPREF9701_RS30750 IMP pyruvate kinase: L-lysine L-lysine E2 protein] N - [sulfur carrier] acetyl-CoA C- acetyl-CoA C- acetyl-CoA C- anhydro-N-acetylmuramic 23S rRNA 11-enoyl-[acp] NAD(P)-dependent two-component sensor tannase/feruloyl dienoyl-[acp] carrier-protein] diphosphate kinase: diphosphate kinase: malic enzyme: NAD-requiring: HMPREF9701_RS28470 HMPREF9701_RS10470 synthase: 2-chloromaleylacetate delta-isomerase: CoA-transferase: gamma-glutamyltransferase: 1-acyl-sn-glycerol-3- glycerol-3-phosphate 1- beta-ketoacyl-[acyl-carrier- 3-hydroxyacyl-[acyl- an oleoyl-[acp] malate dehydrogenase: α-D-glucopyranose HMPREF9701_RS18170 2-pyrone-4,6- hydroxymuconate octanoyl-L-lysine lipoyl synthase: 2,4-cyclodiphosphate acyltransferase: acyltransferase: acyltransferase: (adenine(2030)-N(6))- oxidoreductase: esterase family alpha/ dehydratase FabZ: dGTP HMPREF9701_RS31210 HMPREF9701_RS31210 HMPREF9701_RS17900 HMPREF9701_RS17900 glucose-6-phosphate HMPREF9701_RS12135 HMPREF9701_RS10650 HMPREF9701_RS04805 phosphate acyltransferase: O-acyltransferase PlsY: acid kinase: carrier-protein] histidine kinase: an anion RS22945 an anion a (2E)-hex-2-enoyl-[acp] (2E,5Z)- beta-ketoacyl-[acyl-carrier- HMPREF9701_RS20060 HMPREF9701_RS31415 dicarboxylate hydrolase: isomerase: synthase: HMPREF9701_RS20590 HMPREF9701_RS20325 HMPREF9701_RS20325 protein] synthase I: methyltransferase RlmJ: beta hydrolase: 1-phosphate HMPREF9701_RS10655 HMPREF9701_RS07295a [2-oxoglutarate HMPREF9701_RS04080 HMPREF9701_RS06990 dehydratase FabZ: HMPREF9701_RS12545 HMPREF9701_RS00355 RS08640 tetradeca- HMPREF9701_RS30750 dTTP dCTP isomerase: HMPREF9701_RS22055 HMPREF9701_RS29965 (4,5-dihydro-5- gamma-glutamyltransferase: HMPREF9701_RS01580 HMPREF9701_RS13410 HMPREF9701_RS24220 N-acetyl-D- HMPREF9701_RS07040 a [protein]- HMPREF9701_RS23610 protein] synthase II: an unsulfurated [+ 8 isozymes] [+ 8 isozymes] [+ 8 isozymes] 1-myristoyl-2- an N 6 - [+ 6 isozymes] RS05215 2,5-dienoyl- UTP--glucose-1-phosphate HMPREF9701_RS08440 pyruvate (1E)-4-oxobut- oxofuran-2-yl)-acetate dehydrogenase HMPREF9701_RS17830 (7Z)- 4-trans- 2-trans- 1-(18-hydroxyoleoyl)- a (2E,11Z)-HMPREF9701_RS30750 a cis-delta13-3- RS24705 hexanoyl-[acyl-carrier- a (2E,5Z)-dodeca- HMPREF9701_RS03390 pyruvate (3E,5R)-5-carboxy-2- 5'-deoxyadenosine met 6 2-C-methyl-D-erythritol- a 3-oxohexanoyl- muramate 6- 2030 N-phospho- uridylyltransferase: 2-oxoglutarate 3-oxoadipyl-CoA [sulfur carrier] E2 protein] N L-cysteinylglycine CMP acetyl-CoA acetyl-CoA acetyl-CoA palmitoleoyl-sn- methyladenine gallate [acp] F6P 1-ene-1,2,4- 3-oxoadipate hypoglycin B 2,4-cyclodiphosphate tetradecenoyl-CoA undecenoyl-CoA nonenoyl-CoA sn-glycrol 3-phosphate [acp] phosphate octadeca-2,11- hydroxyC32:1- an anion RS13090 protein] reductase: fabG 3,5-dienoyl-[acp] an (11Z)-3-[+ 2 isozymes] dehydrogenase oxohept-3-enedioate 5-chloro-3-oxoadipate glycerol 3-phosphate in 23S rRNA L-histidine an anion reductase: oxaloacetate HMPREF9701_RS09715 tricarboxylate enol-lactonase: -lipoyl-L-lysine dienoyl-[acp] [acp] oxo-icos-11- E1 component: FAA hydrolase 3-oxoadipyl-CoA thiolase: fabG phosphoenolpyruvate α mannose-1-phosphate 4-oxalomesaconate HMPREF9701_RS19370 a hexanoyl-[acp] enoyl-[acp] UDP- -D-glucose HMPREF9701_RS26950 family protein: HMPREF9701_RS10645 RS25055 synthase: guanylyltransferase/ tautomerase: a (5Z)-tetradec- 3-oxoacyl- HMPREF9701_RS10250 a [pyruvate (11Z)-3-oxo- 6-cis, 3-oxo- a cytidine 1402 6-O-cis-methoxy- uridine 2'3'-cyclic a (9Z)-3- HMPREF9701_RS31415 mannose-6- [+ 2 isozymes] 3-oxoadipate a very-long- propanoate decanoyl-CoA acetyl-CoA 1-palmitoyl-sn- L-tartrate a cation RS15535 a cation RS25975 HMPREF9701_RS22875 succinyl-CoA dehydrogenase a sulfurated scyllo-inosose a decanoyl-[acp] mycolyl-trehalose monophosphate oxooctacos- butan-1-ol RS13170 beta-ketoacyl-[acyl-carrier- 5-enoyl-[acp] a (5Z)-dodec- ACP phosphate isomerase: (1E,3E)-4- SAM chain fatty acid hexadecenoyl-CoA tridecenoyl-CoA glycerol 3-phosphate in 16S rRNA (4Z)-2-oxohept-4-enedioate 6 bifunctional 2',3'- protein] synthase I: reductase 2-maleylacetate 3-oxoadipate E2 protein] N - [sulfur carrier] fatty acid--CoA ligase: propionate--CoA ligase: acetyl-CoA C- acetyl-CoA C- acetyl-CoA C- myo-inosose-2 16S rRNA (cytidine(1402) 6-phosphate 9-enoyl-[acp]NAD(P)-dependent tartrate dehydrogenase: NAD(P)-dependent beta-ketoacyl-[acyl-carrier- 5-enoyl-[acp] phosphoenol HMPREF9701_RS10410 hydroxybuta- 1-acyl-sn-glycerol-3- beta-ketoacyl-[acyl-carrier- cyclic-nucleotide 2'- HMPREF9701_RS24220 FabG: fabG CoA-transferase: octanoyl-L-lysine lipoyl synthase: HMPREF9701_RS21695 HMPREF9701_RS28475 acyltransferase: acyltransferase: acyltransferase: dehydratase: -2'-O)-methyltransferase: trehalose-phosphatase: oxidoreductase: HMPREF9701_RS17865 alcohol dehydrogenase: protein] synthase II: pyruvate D-mannopyranose 1,3-diene-1,2,4- 2-oxo-hepta-3-ene-1,7- phosphate acyltransferase: protein] synthase I: phosphodiesterase/ [+ 5 isozymes] HMPREF9701_RS10650 HMPREF9701_RS07295 [+ 10 isozymes] [+ 11 isozymes] HMPREF9701_RS20590 HMPREF9701_RS20325 HMPREF9701_RS20590 HMPREF9701_RS18465 HMPREF9701_RS25890 HMPREF9701_RS06815 HMPREF9701_RS12545 tartrate dehydrogenase: HMPREF9701_RS07550a cation RS27545 a cation RS15070 [+ 2 isozymes] HMPREF9701_RS03390 6-phosphate tricarboxylate dioic acid hydratase: a [pyruvate HMPREF9701_RS04080 HMPREF9701_RS24220 3'-nucleotidase: a (3R,11Z)-3- Metabolic Regulator Biosynthesis phosphopyruvate HMPREF9701_RS10655 [+ 8 isozymes] [+ 8 isozymes] [+ 8 isozymes] 1-palmitoyl-2- 3D-(3,5/4)- a 2'-O- trehalose- HMPREF9701_RS15975 [+ 2 isozymes] O-antigen building blocks biosynthesis (E. coli) phosphomannomutase/ 4-oxalmesaconate HMPREF9701_RS12550 an unsulfurated dehydrogenase a very-long-chain a 3- a cis-delta9-3-[+ 6 isozymes] hydroxy-icos- hydratase: 5'-deoxyadenosine met AMP diphosphate AMP diphosphate propanoyl-CoA (9Z)- 4-cis- 3-oxododecanoyl- trihydroxycyclohexane- methylcytidine 1402 HMPREF9701_RS19540 2-hydroxy-3- butan-1-al a 3-oxooctanoyl-[acp] a (7Z)-3-oxo- hydratase: [sulfur carrier] E2 protein] N 6 fatty acyl-CoA acetyl-CoA acetyl-CoA palmitoleoyl-sn- oxododecanoyl- cis-methoxy- hydroxyC28:1- RS04350 RS25425 HMPREF9701_RS26595 phosphoglucomutase: [+ 2 isozymes] 3-oxoadipate 3-oxoadipyl-CoA tetradecenoyl-CoA undecenoyl-CoA CoA oxosuccinate 11-enoyl-[acp] ppGpp biosynthesis UDP-α-D- α-D- glycerol 3-phosphate 1,2-dione [acp] in 16S rRNA mono-mycolate 3'-UMP hexadec-7- trehalose biosynthesis I D-glucopyranose HMPREF9701_RS28470 HMPREF9701_RS22865 (4S)-4-hydroxy-2- -lipoyl-L-lysine [acp] a cation RS00670 a cation NAD(P)-dependent stearate biosynthesis 3-hydroxyacyl-[acyl- phosphopyruvate galactose 2-hydroxy-4- enoyl-[acp] glucopyranose 6-phosphate α 3-oxoadipyl-CoA thiolase: oxidoreductase: II (bacteria and plants) carrier-protein] hydratase: glucose-6-phosphate -D-mannose oxobutane-1,2,4- oxoheptanedioate 3-oxoacyl- pppGpp D-glucopyranose 1-phosphateglucose-1-phosphate HMPREF9701_RS10645 RS19755 HMPREF9701_RS12545 dehydratase FabZ: bifunctional (p)ppGpp α HMPREF9701_RS02595 isomerase: 1-phosphate 4-hydroxy-2- undecaprenyl-diphospho-N 34 2251 a protein with ACP UDP- -D-glucose tricarboxylate α all-trans- a guanine 3-oxo-(5Z)- guanosine D-arabinofuranose (S)-1-pyrroline- 6-phosphate Cell Structure Biosynthesis UDP-Galf thymidylyltransferase: HMPREF9701_RS10470 -acetylmuramoyl-L-alanyl-γ- UDP-N-acetyl-α-D-glucosamine -linolenate phytenate succinyl-CoA a 3-oxo acid cis-dienelactone queuine 2-phosphoglycolate salicyloyl-CoA butan-1-ol [+ 6 isozymes] reductase a palmitoyl-[acp] HMPREF9701_RS30750 synthetase/guanosine- trehalose-6- 2-phospho- mannose-1-phosphate 4-carboxy-4-hydroxy- oxoheptanedioate aldolase: succinyl-CoA acetyl-CoA retinyl palmitate in tRNA dodecenoyl-CoA in 23S rRNA 5-phosphate reduced L- 5-carboxylate a cation RS21050 a cation HMPREF9701_RS24205 D-glutamyl-L-lysyl- D-alanine fatty acid--CoA ligase: fatty acid--CoA ligase: acyl CoA:acetate/3- carboxymethylenebutenolidase: phospholipase/ tRNA guanosine(34) acetyl-CoA C- 23S rRNA phosphoglycolate 3-deoxy-8- delta-1-pyrroline- bifunctional salicylyl- RS23100 FabG: fabG beta-ketoacyl-[acyl-carrier- a (2E,11Z)-icosa- 3',5'-bis(diphosphate) 3'- phosphate synthase: D-glycerate dTDP-α-D-glucose glucose-6-phosphate guanylyltransferase: 2-oxoadipate HMPREF9701_RS16030 undecaprenyldiphospho- cysteine residues NAD(P)-dependent RS19590 a (3R)-3-hydroxyoctanoyl-[acp] pyrophosphohydrolase: HMPREF9701_RS10410 HMPREF9701_RS21695 HMPREF9701_RS21695 ketoacid CoA transferase: HMPREF9701_RS12520 carboxylesterase: transglycosylase Tgt: acyltransferase: (guanosine(2251)-2'-O)- phosphatase: phosphooctulonate 5-carboxylate CoA 5-hydroxylase/ [+ 5 isozymes] protein] synthase I: 2,11-dienoyl-[acp] α,α-trehaloseHMPREF9701_RS06820 peptidoglycan biosynthesis I (meso-diaminopimelate containing) isomerase: aldolase/oxaloacetate [+ 2 isozymes] aromatic compounds degradation via β-ketoadipate muramoylpentapeptide beta-N- DSBA oxidoreductase: alcohol dehydrogenase: HMPREF9701_RS22155 Kdo transfer to lipid IV I dTDP-glucose α [+ 10 isozymes] [+ 10 isozymes] HMPREF9701_RS21590 HMPREF9701_RS23485 HMPREF9701_RS22475 HMPREF9701_RS20325 methyltransferase RlmB: HMPREF9701_RS03450 synthase: dehydrogenase: oxidoreductase: a (3R,7Z)-3- HMPREF9701_RS24220 A HMPREF9701_RS08440 GDP- -D- decarboxylase: acetylglucosaminyltransferase: carboxymethylenebutenolidase: HMPREF9701_RS00415 HMPREF9701_RS07550 a 3-oxooctadecanoyl- 6-phosphate 4,6-dehydratase: succinate semialdehyde a cation RS24500 a cation RS02735 3-hydroxyacyl-[acyl-carrier- α HMPREF9701_RS12025 34 [+ 8 isozymes] HMPREF9701_RS28795 [+ 2 isozymes] HMPREF9701_RS02585 HMPREF9701_RS19300 HMPREF9701_RS25375 hydroxy-hexadec- bifunctional (p)ppGpp UDP-N-acetyl- -D-glucosamine F6P mannose HMPREF9701_RS22860 ditrans,octacis-undecaprenyldiphospho-HMPREF9701_RS04620 [+ 2 isozymes] [+ 2 isozymes] a queuosine 2-O- protein] dehydratase FabZ: [acp] guanosine 3'-diphosphate trehalose-phosphatase: 3-phospho- HMPREF9701_RS24215 protocatechuate AMP diphosphate α-linolenoyl-CoA diphosphate AMP phytenoyl-CoA a 2,3,4-saturated guanine (3Z)-dec-3- a protein with butan-1-al 7-enoyl-[acp] synthetase/guanosine- CMP-Kdo lipid IV + succinate 2-maleylacetate palmitate all-trans-retinol in tRNA acetyl-CoA 2251 glycolate gentisyl-CoA A NADP -dependent UDP N-acetyl-(N-acetylglucosaminyl)muramoyl- methylguanosine KDO-8P glu HMPREF9701_RS30750 NAD(P)-dependent 5'-triphosphate 3'- HMPREF9701_RS06815 UDP-N-acetylglucosamine D-glycerate dTDP-4-dehydro- glutamine--fructose-6- oxaloacetate 3-oxoacyl-CoA enoyl-CoA a disulfide bond RS24695 3-hydroxyacyl-[acyl- 3',5'-bis(diphosphate) 3'- 3-deoxy-D-manno- succinate- L-alanyl-γ-D-glutamyl-L-lysyl-D-alanine in 23S rRNA RS08825 oxidoreductase: diphosphatase: 1-carboxyvinyltransferase: 6-deoxy-α-D- phosphate transaminase carrier-protein] a gondoyl-[acp] pyrophosphohydrolase: α,α-trehalose octulosonic acid phosphoglycerate kinase: semialdehyde a cation RS09700 a cation a (2E)-oct-2-enoyl-[acp] HMPREF9701_RS12545 HMPREF9701_RS22155 HMPREF9701_RS10825 glucopyranose (isomerizing): 4-carboxy-4-hydroxy- catechol dehydratase FabZ: HMPREF9701_RS01610 transferase: HMPREF9701_RS14085 dehydrogenase: gabD RS10690 UDP-N-acetylglucosamine dTDP-4-dehydrorhamnose HMPREF9701_RS06950 2-oxoadipate adenine 2503 α,ω-9Z- 3-oxo-(7Z)- a [protein]-L- HMPREF9701_RS30750 [+ 6 isozymes] HMPREF9701_RS28465 3-carboxy-cis adenosylcobinamide- phenyl ribotide + a [protein]- sn-glycerol long chain PRPP biosynthesis aldolase/oxaloacetate succinate- catechol 1,2-dioxygenase: succinyl-CoA acetoacetate hydrogencarbonate H FAD D-glycerate L(or D)-O- roseoflavin acetamide octanoyl-[acyl-carrier- a (2E,7Z)- a (3R)-3- 1-carboxyvinyltransferase: α-Kdo-(2->6)-lipid IV 3,5-epimerase: D-glucosamine ,cis-muconate in 23S rRNA GDP phosphate octadecenedioate tetradecenoyl-CoA L-threonine a hexanoyl-[acp] proline (ω = 180) 3-phosphate polyphosphate A 13-DPG HMPREF9701_RS12145 carbonate dehydratase: glyoxylate/hydroxypyruvate phosphoserine protein] reductase: fabG hydroxyoctadecanoyl- HMPREF9701_RS26825 HMPREF9701_RS24200 6-phosphate decarboxylase: semialdehyde 23S rRNA adenosylcobinamide- fatty acid--CoA ligase: acyl CoA:acetate/3- acetyl-CoA C- FAD:protein FMN FKBP-type peptidyl-prolyl polyphosphate kinase 2: bifunctional riboflavin amidase: a cation RS01640 a cation hexadeca-2,7- D-ribose 5- catechol 1,2-dioxygenase: 3-carboxy-cis,cis- beta-ketoacyl-[acyl-carrier- glycerol-3-phosphate 1- phosphoserine RS30135 [acp] α KDO transferase: dTDP-4-dehydro- HMPREF9701_RS22860 dehydrogenase: gabD (adenine(2503)-C(2))- GDP ribazoletransferase: HMPREF9701_RS21695 ketoacid CoA transferase: acyltransferase: HMPREF9701_RS19060 transferase: reductase A: cis-trans isomerase: HMPREF9701_RS22130 kinase/FAD synthetase: RS30940 dienoyl-[acp] UDP-N-acetyl- -D- glyceraldehyde-3- phosphoglucosamine phosphate muconate cycloisomerase: protein] synthase I: O-acyltransferase PlsY: HMPREF9701_RS12105 HMPREF9701_RS28465 β ribose-phosphate HMPREF9701_RS05130 methyltransferase RlmN: HMPREF9701_RS08495 [+ 10 isozymes] HMPREF9701_RS21590 HMPREF9701_RS20590 carbonic anhydrase: HMPREF9701_RS31365 HMPREF9701_RS19165 HMPREF9701_RS02530 phosphatase SerB: an octanoyl-[acp] (2E,7Z)- 3-hydroxyacyl-[acyl- biotin-carboxyl carrier protein assembly glucosamine-enolpyruvate triose-phosphate phosphate dehydrogenase: -L-rhamnose mutase: NADP-dependent HMPREF9701_RS13410 polyphosphate kinase 1: HMPREF9701_RS11715 [+ 3 isozymes] α α succinate 2,5-xylenol and 3,5-xylenol degradation HMPREF9701_RS04785 HMPREF9701_RS31205 phenyl-Coβ- ω-carboxy- HMPREF9701_RS24220 α ω HMPREF9701_RS01560 RS05830 hexadeca- carrier-protein] GTP ppGpp -Kdo-(2->4)- - dTDP-4-dehydrorhamnose HMPREF9701_RS30680 pyrophosphokinase: malic enzyme: cis,cis-muconate [+ 2 isozymes] [+ 8 isozymes] HMPREF9701_RS24990 a [protein]-FMN- [+ 3 isozymes] [+ 9 isozymes] 1-C16:0- , - HMPREF9701_RS30665 roseoflavin UDP-N- isomerase: HMPREF9701_RS18125 2503 (5Z)- a [protein]-L- a cation RS06400 a cation dehydratase FabZ: Kdo-(2->6)-lipid IV HMPREF9701_RS11450 3-carboxy-cis,cis- a 2-methyladenine GMP adenosylcobamide AMP diphosphate (9Z)-octadec- AMP a 3-oxooctanoyl- dicarboxyl-2- long chain acetate beta-ketoacyl-[acyl-carrier- 2,7-dienoyl- a [biotin carboxyl- A reductase: HMPREF9701_RS17900 5'-deoxyadenosine met acetoacetyl-CoA succinate acetyl-CoA H O CO L-threonine hydroxypyruvate serine 5'-phosphate acetylenolpyruvoylglucosamine HMPREF9701_RS02960 D-glyceraldehyde D-glucosamine PRPP muconate cycloisomerase: in 23S rRNA 5'-phosphate 9-enoyl-CoA dodecenoyl-CoA 2 2 [acp] proline (ω = 0) polyphosphate protein] synthase I: [acp]: fabG HMPREF9701_RS30750 carrier protein]-L-lysine DHAP HMPREF9701_RS24210 3,5-xylenol 2,5-xylenol muconate cycloisomerase: lysophosphatidate reductase: 3-phosphate 1-phosphate pyruvate HMPREF9701_RS18265 dTDP-β-L- HMPREF9701_RS12130 RS04725 HMPREF9701_RS24220 a (7Z)-hexadec- a (2E)-octadec- biotin--[acetyl-CoA- HMPREF9701_RS13455 UDP-N-acetylglucosamine (2-carboxy-2,5- RS26350 nucleoside- ala rhamnose a cation RS22745 a cation [+ 2 isozymes] 7-enoyl-[acp] 2-enoyl-[acp] carboxylase] ligase: a 1-alkyl-sn (E)-5-methyl- glu UDP-N-acetyl-α-D-muramate diphosphorylase/ benzoyl-CoA (+)-muconolactone dihydro-5-oxofuran- decaprenyl-diphospho-N- UDP-N-acetyl- 4-methylphenyl 3-oxo-(11Z)- 1-carboxyvinyl a [release factor]- RS09630 diphosphate kinase: bifunctional (p)ppGpp adenosylcobinamide- N 1 -methyladenine 2-oxoglutarate acetyl-CoA (S)-5-hydroxyisourate enterobactin acetyl-CoA squalene phytol beta-ketoacyl-[acyl-carrier- HMPREF9701_RS14355 glucosamine-1-phosphate 2-yl)-acetate acetylmuramoyl-pentapeptide α-D-glucosamine ribotide cob(II)yrinate hexanoyl-CoA -glycerol 3- 2-oxo-3-hex- a 3-oxodecanoyl-[acp] HMPREF9701_RS31210 fructose-bisphosphate degradation I (aerobic) 3-(hydroxymethyl) 5-(hydroxymethyl) ATP octadecenoyl-CoA carboxyphosphonate L-glutamine a [biotin carboxyl-carrier synthetase/guanosine- N-acetyltransferase: undecaprenyldiphospho- GDP DNA oxidative acetyl-CoA C- acetyl-CoA C- phosphate acetyl-CoA carboxylase squalene synthase HpnC: 3-enedioate protein] synthase II: GDP pyrophosphokinase: glutamate racemase: UDP-N-acetylmuramate- aldolase class II: α adenosylcobinamide-phosphate a,c-diamide carboxyvinyl- peptide chain release NAD(P)-dependent 6 3',5'-bis(diphosphate) 3'- UDP- -D-galactose -5-methylphenol -2-methylphenol 1-acyl-sn-glycerol-3- 2-oxo-hepta-3-ene-1,7- HMPREF9701_RS03390 protein]-N -biotinyl-L-lysine HMPREF9701_RS06970 muconolactone 4-carboxymuconolactone muramoylpentapeptide beta-N- demethylase AlkB: cob(I)yrinic acid a,c-diamide acyltransferase: acyltransferase: hydroxyisourate hydrolase: carboxyphosphonate factor N(5)-glutamine enterochelin esterase: biotin carboxylase subunit: HMPREF9701_RS15275 a cation RS24190 a cation NAD(P)-dependent HMPREF9701_RS22155 HMPREF9701_RS01005 -L-alanine ligase: HMPREF9701_RS18145 biosynthesis benzoyl-CoA GDP ribazoletransferase: alcohol dehydrogenase: pyrophosphohydrolase: lipid IV biosynthesis N-acetyl-α-D- NAD(P)-dependent NAD(P)-dependent delta-isomerase: decarboxylase: acetylglucosaminyltransferase: HMPREF9701_RS17450 adenosyltransferase: HMPREF9701_RS20590 HMPREF9701_RS20590 HMPREF9701_RS17825 phosphorylmutase: phosphate acyltransferase: methyltransferase: HMPREF9701_RS12860 HMPREF9701_RS04500 dioic acid hydratase: RS29250 oxidoreductase: [+ 2 isozymes] a stearoyl-[acp] HMPREF9701_RS04615 A benzoyl-CoA 2,3-epoxidase: HMPREF9701_RS08495 squalene synthase HpnD: HMPREF9701_RS07550 RS12125 HMPREF9701_RS22155 alcohol dehydrogenase: alcohol dehydrogenase: HMPREF9701_RS12135 HMPREF9701_RS15300 HMPREF9701_RS04620 4-methylphenyl-Co adenosyl-HMPREF9701_RS01330 HMPREF9701_RS04080 HMPREF9701_RS05125 a (9Z)-3-oxo- D-glt UDP-α-D-glucose glucosamine HMPREF9701_RS29800 [+ 8 isozymes] [+ 8 isozymes] (S)-2-oxo-4- HMPREF9701_RS16555 a 2-acyl-1-alkyl- HMPREF9701_RS11235 N-(2,3- [+ 4 isozymes] HMPREF9701_RS15280 RS30110 HMPREF9701_RS12545 a (3R)-3- HMPREF9701_RS07550 HMPREF9701_RS07550 decaprenyl-pyrophosphoryl- β-adenosylcobamide 3-oxooctanoyl- 3-(hydroxyphosphinoyl) a [release factor]-N 5 (4E)-2-oxo- phytenal octadec-9- bifunctional (p)ppGpp α UDP-N-acetyl- 1-phosphate HMPREF9701_RS29805 GMP succinate formaldehyde adenine triphosphate cobyrinate palmitoleoyl-CoA acetyl-CoA hydroxy-4-carboxy- dihydroxybenzoyl) malonyl-CoA presqualene [+ 6 isozymes] a [biotin carboxyl- UDP-N-acetyl- -D-muramoyl-L-alanine hydroxytetradecanoyl- β UDP-glucose 4- 2,3-epoxy-2,3- UDP (N-acetylglucosamine)-N- sn-glycerol hex-4-enoate a cation RS28340 a cation enoyl-[acp] synthetase/guanosine- α -D-fructose 1,6- 3-hydroxy-5- 3-hydroxy-4- (4,5-dihydro-5- 5'-phosphate a,c-diamide CoA 5-ureidoimidazoline pyruvate -methyl-L-glutamine -L-serine diphosphate carrier-protein dimer]- -D-glucosamine epimerase GalE: UDP-N-acetylglucosamine dihydrobenzoyl- acetylmuramyl-(pentapeptide) 3-phosphate 3-oxoacyl- 3',5'-bis(diphosphate) 3'- [acp] UDP-N-acetylglucosamine bisphosphate methylbenzaldehyde methylbenzaldehyde oxofuran-2-yl)-acetate a (3R)-3-hydroxydecanoyl-[acp] N 6 -biotinyl-L-lysine UDP-N-acetylmuramoyl-L- acyltransferase: HMPREF9701_RS10725 diphosphorylase/ CoA ACP pyrophosphohydrolase: fructose 1,6- UDP-α-D-galactose 3-oxoadipate stearate acetyl-CoA carboxylase alanine--D-glutamate ligase: UDP-3-O-[(3R)-3-HMPREF9701_RS30745 glucosamine-1-phosphate 2,3-epoxybenzoyl- RS25035 reductase HMPREF9701_RS01610 bisphosphatase: enol-lactonase: 2,5-dichloro-trans a [protein] N-terminal- 6-O-trans-methoxy- 1-myristoyl- a uracil 1939 a uridine 38- a uracil 1498 4-methyl-3- a cation RS23205 a cation RS02330 bifunctional 3- HMPREF9701_RS04630 N-acetyltransferase: CoA dihydrolase: a proteinogenic anthranilate 3-dimethylsulfoniopropionaldehyde butanoyl-CoA acetyl-CoA octanoyl-CoA acetyl-CoA isovaleryl-CoA nitrite RS30105 FabG: fabG carboxyltransferase GDP hydroxymyristoyl]-N- HMPREF9701_RS25305 HMPREF9701_RS19370 leukotriene-C4 -dienelactone formyl-L-methionine mycolyl-trehalose sn-glycerol 40 in tRNA oxoadipate- hydroxydecanoyl-ACP long-chain acyl- HMPREF9701_RS06970 HMPREF9701_RS29810 amino acid in 23S rRNA in 16S rRNA subunit beta: α acetyl-α-D-glucosamine 3-hydroxy-5- 3-hydroxy-4- 2-aminobenzoate- carboxymethylenebutenolidase: peptide deformylase: acetyl-CoA C- acetyl-CoA C- 6-phosphate 3-phosphate 23S rRNA tRNA pseudouridine(38- isovaleryl-CoA enol-lactone [+ 5 isozymes] CoA synthetase: acetyl-CoA carboxylase meso-diaminopimelate UDP-N-acetyl- -D-muramoyl- UDP-N-acetyl- cis-3,4- gamma-glutamyltransferase: aldehyde dehydrogenase 16S rRNA (uracil(1498)- nitrate reductase dehydratase/trans-2- HMPREF9701_RS03275 UDP-3-O-[3- F6P methyl-benzoate methyl-benzoate 3-oxoadipate CoA ligase: HMPREF9701_RS12520 HMPREF9701_RS14110 acyltransferase: acyltransferase: 1-acyl-sn-glycerol-3- (uracil(1939)-C(5))- 40) synthase TruA: dehydrogenase: 3-oxoadipate a (3R,9Z)-3- HMPREF9701_RS04965 biotin carboxylase subunit: L-alanyl-D-glutamate α-D-glucosamine dehydroadipyl- HMPREF9701_RS04805 (NAD(+)): trehalose-phosphatase: N(3))-methyltransferase: subunit beta: decenoyl-ACP isomerase: hydroxymyristoyl] N- 3-hydroxybenzoate 3-hydroxybenzoate HMPREF9701_RS25395 HMPREF9701_RS20590 HMPREF9701_RS20590 phosphate acyltransferase: methyltransferase RlmD: HMPREF9701_RS03255 HMPREF9701_RS19055 enol-lactonase: a cation RS23215 a cation hydroxy-octadec- acetyl-CoA carboxylase HMPREF9701_RS04500 CoA semialdehyde carboxymethylenebutenolidase: HMPREF9701_RS30475 peptide deformylase: HMPREF9701_RS06815 HMPREF9701_RS29390 HMPREF9701_RS25010 HMPREF9701_RS24225 [+ 10 isozymes] acetylglucosamine glucose-6-phosphate 3-oxoadipate gamma-glutamyltransferase: HMPREF9701_RS04080 3 HMPREF9701_RS19370 9-enoyl-[acp] carboxyltransferase D-ala UDP-N-acetylmuramoyl-L- 6-hydroxylase: 6-hydroxylase: HMPREF9701_RS12025 HMPREF9701_RS27460 [+ 8 isozymes] [+ 8 isozymes] HMPREF9701_RS06330 [+ 3 isozymes] [+ 2 isozymes] an N - isomerase: 1,2-dimyristoyl- 1939 38- RS31355 3-hydroxyacyl-[acyl-carrier- deacetylase: CoA-transferase: HMPREF9701_RS17830 diphosphate AMP anthraniloyl-CoA DMSP an N-terminal L- 3-oxohexanoyl- 3-oxodecanoyl- trehalose-trans- a 5-methyluracil a pseudouridine 3-methylcrotonyl- 1498 4-methyl-3- nitrate RS26985 RS27005 3-hydroxyacyl-[acyl- stearoyl-CoA subunit alpha: alanyl-D-glutamate--2, 6- HMPREF9701_RS17090 HMPREF9701_RS17090 an α-(γ-L-glutamyl) 2,5-dichloromaleylacetate formate sn-glycerol methyluracil protein] dehydratase FabZ: HMPREF9701_RS04590 HMPREF9701_RS10470 HMPREF9701_RS10650 leukotriene-D4 methionyl-[protein] CoA CoA methoxy-mono-mycolate in 23S rRNA 40 in tRNA CoA oxoadipate carrier-protein] HMPREF9701_RS23415 D-alanine--D-alanine ligase: diaminopimelate ligase: -L-amino acid 3-phosphate in 16S rRNA D-ribose RS05855 D-ribose HMPREF9701_RS30750 UDP-3-O-(3- glucose-6-phosphate cis-3,4- 3-methylgentisate 4-methylgentisate HMPREF9701_RS10655 dehydratase FabZ: a [carboxyl-carrier HMPREF9701_RS04610 HMPREF9701_RS04645 6 hydroxymyristoyl) isomerase: dehydroadipyl- HMPREF9701_RS30750 protein dimer]-N - -α-D-glucosamine CoA 3-methylgentisate 4-methylgentisate 3-oxoadipyl-CoA (R)-3-((R)-3- a (2E)-dec-2-enoyl-[acp] a (2E,9Z)- carboxybiotinyl-L-lysine UDP-N-acetyl-α-D-muramoyl-L-alanyl- HMPREF9701_RS08440 3-oxo-2-(cis-2'-pentenyl)- an electron- 5-cis, 7-trans-3-oxo- 3-oxo- 3-oxo-(5Z)- 3-oxo-4-pregnene- a negatively (3E)-2-oxohex- D-alanyl-D-alanine NADH + a phosphate nitrate γ UDP-3-O-(3- 1,2-dioxygenase: 1,2-dioxygenase: acetyl-CoA H 3,4-dihydroxyphenylacetaldehyde β-alanine a [protein] Ser/Thr hydroxybutanoyloxy) D-ribose RS04885 D-ribose RS25990 RS22965 octadeca-2,9- -D-glutamyl-meso-2,6-diaminopimelate D-glucopyranose 3-oxoadipyl-CoA thiolase: dGTP cyclopentane-1-hexanoyl-CoA transfer quinone tetradecadienoyl-CoA palmitoyl-CoA tetradecenoyl-CoA 20-carboxyl-CoA supercoiled DNA 3-enedioate monoester RS13790 hydroxymyristoyl) HMPREF9701_RS17085 HMPREF9701_RS17085 acetyl-CoA C- NADH-quinone acetyl-CoA C- acetyl-CoA C- acetyl-CoA C- serine/threonine -butanoate acetyl-CoA C- DNA topoisomerase III: decanoyl-[acyl-carrier- dienoyl-[acp] phosphatidylglycerol 6-phosphate HMPREF9701_RS10645 aldehyde dehydrogenase 2-oxo-hepta-3-ene-1,7- alkaline phosphatase D: nitrate reductase UDP-N-acetylmuramoyl- glucosamine N- (2E)-2-methyl-4,6- (2E)-3-methyl-4,6- deoxyguanosinetriphosphate acyltransferase: oxidoreductase subunit B: acyltransferase: acyltransferase: acyltransferase: 4-aminobutyrate--2- protein kinase: hydroxybutyrate- acyltransferase: HMPREF9701_RS20890 protein] reductase: fabG biosynthesis I (plastidic) trans-2,3- (NAD(+)): dioic acid hydratase: HMPREF9701_RS31255 subunit beta: acyltransferase: dioxohept-2-enedioate triphosphohydrolase: HMPREF9701_RS20325 oxoglutarate transaminase: dimer hydrolase: tripeptide--D-alanyl- dioxohept-2-enedioate HMPREF9701_RS20325 HMPREF9701_RS02940 HMPREF9701_RS30475 HMPREF9701_RS20325 HMPREF9701_RS20590 HMPREF9701_RS22175 HMPREF9701_RS20325 DNA topoisomerase III: HMPREF9701_RS05125 HMPREF9701_RS25010 A(H2) thiosulfate dehydroadipyl-coA succinyl-CoA HMPREF9701_RS10600 HMPREF9701_RS31340 HMPREF9701_RS15360 [+ 3 isozymes] DHAP D- alanine ligase: HMPREF9701_RS30755 [+ 8 isozymes] [+ 3 isozymes] [+ 8 isozymes] [+ 8 isozymes] [+ 8 isozymes] [+ 2 isozymes] [+ 8 isozymes] HMPREF9701_RS00675 (2Z)-2- tetrathionate a decanoyl-[acp] UDP-2-N,3-O-bis[(3R)- 2'-deoxyguanosine triphosphate 3-oxo-2-(cis-2'-pentenyl)- an electron- 3,4-dihydroxyphenylacetate (3Z,5E)-dodeca- (3Z)-dodec- (R)-3- 3,22-dioxochol- nitrite reductase glycerol-3-phosphate phosphatidylethanolamine HMPREF9701_RS04640 4,5-dichlorocatechol degradation NAD + acetyl-CoA myristoyl-CoA acetyl-CoA 3-oxopropanoate a [protein] (L-serine/L- a relaxed DNA hydroxypenta- an alcohol RS15810 an oleoyl-[acp] 3-hydroxytetradecanoyl]- acetyl-CoA hydroxybutanoate A tetrathionate RS10580 dehydrogenase: biosynthesis I cyclopentane-1-(3-oxooctanoyl)-CoA transfer quinol 3,5-dienoyl-CoA 3-enoyl-CoA threonine) phosphate 4-en-24-oyl-CoA 2,4-dienoate RS15775 beta-ketoacyl-[acyl-carrier- α-D-glucosamine HMPREF9701_RS12385 UDP-N-acetyl-α-D-muramoyl-L- (3S)- 4,5-dichlorobenzene- biotin RS05950 biotin protein] synthase I: UDP-2,3-diacylglucosamine sn-glycerol a CDP-diacylglycerol alanyl-γ-D-glutamyl-meso-2,6- di-trans,octa-cis-undecaprenyl phosphate hydroxyadipyl- citraconate 1,2-diol HMPREF9701_RS24220 diphosphatase: nicotinate degradation I 1-oleoyl-sn 3-phosphate diaminopimeloyl-D-alanyl-D-alanine CoA 3-oxo-2-(cis-2'-pentenyl)- (6Z,9Z,12Z,15Z,18Z,21Z)-3- 10 an (S)-2- a double 3-oxo- (R)-3- a double (R)-2-methylmalate cob(II)alamin- acetyl-CoA an N - hydroxypyruvaldehyde DNA with lesion nitrite Zn 2+ RS05460 Zn 2+ [+ 2 isozymes] HMPREF9701_RS23445 methylmalonyl- cyclopentane-1-butanoyl-CoA phe halocarboxylate myristoyl-CoA -glycerol 3- hydroxybutanoate glycerol-3-phosphate 1- 2,3-dichloro- ATP [CblC-CblD oxotetracosahexaenoyl-CoA formyltetrahydrofolate stranded DNA phosphate oxaloacetate ITP stranded DNA biotin ATP lipid A RS26770 hydro-lyase (2- CoA mutase acetyl-CoA C- acetyl-CoA C- HAD family hydrolase: exodeoxyribonuclease V: acetyl-CoA C- phosphate 3-hydroxybutyrate DNA gyrase subunit A: excinuclease ABC lipid A O-acyltransferase PlsY: a 3-sn-phosphatidyl-L-serine lipid X cis,cis-muconate nicotinate complex] phenylalanine 4- aldehyde dehydrogenase phosphoenolpyruvate nitrate reductase RS29220 a 3-oxododecanoyl-[acp] palmitoleate biosynthesis I methylmaleate-forming): cob(I)yrinic acid a,c-diamide acyltransferase: acyltransferase: HMPREF9701_RS15330 HMPREF9701_RS22685 acyltransferase: 1-acyl-sn-glycerol-3- dehydrogenase: HMPREF9701_RS14835 subunit UvrC: biotin--[acetyl-CoA- RS24045 HMPREF9701_RS13410 nicotinate dehydrogenase: monooxygenase: (NAD(+)): subunit beta: (from (5Z)-dodec-5-enoate) HMPREF9701_RS03225 adenosyltransferase: HMPREF9701_RS20325 HMPREF9701_RS20325 HMPREF9701_RS20590 carboxykinase (GTP): phosphate acyltransferase: HMPREF9701_RS04265 HMPREF9701_RS01985 carboxylase] ligase: Na + RS11700 Na + a 1-acyl-sn phosphatidylserine undecaprenyldiphospho- lipid-A-disaccharide 3-oxoadipyl-CoA HMPREF9701_RS24255 haloacid dehalogenase: HMPREF9701_RS22690 DNA gyrase subunit A: HMPREF9701_RS25010 HMPREF9701_RS12195 10 HMPREF9701_RS30475 HMPREF9701_RS30025 HMPREF9701_RS04080 NAD(P)-dependent -glycerol 3- N-acetylmuramoyl-L-alanyl- synthase: a [cobalamin HMPREF9701_RS01330adenosylcobalamin- [+ 8 isozymes] [+ 8 isozymes] 4a-hydroxy-N - HMPREF9701_RS12675 HMPREF9701_RS22695 [+ 8 isozymes] [+ 2 isozymes] HMPREF9701_RS05655 [+ 3 isozymes] HMPREF9701_RS14355 a (5Z)-dodec- decarboxylase: (R)-citramalate 6-hydroxynicotinate a [cyanocobalamin tyr phosphoenol dioleoyl biotinyl-5'- oxidoreductase: γ trafficking triphosphate [methylmalonyl- 3-oxo-2-(cis-2'-pentenyl)- (4Z,7Z,10Z,13Z,16Z,19Z) formyltetrahydrofolate an (R)-2- 3-phosphooxypyruvate IDP a negatively DNA without nitrate RS08685 5-enoyl-[acp] phosphate HMPREF9701_RS06480 -D-glutamyl-meso-2,6- HMPREF9701_RS30740 3-oxoadipyl-CoA thiolase: 2-chloro-2-(2-chloro- reductase CblC] acetyl-CoA a halide anion a 5'-phosphooligonucleotide acetyl-CoA lauroyl-CoA pyruvate acetoacetate adenylate HMPREF9701_RS12545 beta-ketoacyl-[acyl-carrier- protein CblD] CoA mutase] cyclopentane-1-(3-oxohexanoyl)-CoA -docosahexaenoyl-CoA hydroxyacid phosphatidate supercoiled DNA lesion lactate 1-acyl-sn-glycerol-3- RNA polymerase diaminopimeloyl-D-alanyl-D-alanine HMPREF9701_RS10645 5-oxofuran-2-yl)acetate 6-hydroxynicotinate RS18085 lactate [+ 6 isozymes] protein] synthase II: lipid A disaccharide RS14165 phosphate acyltransferase: sigma factor FliA: fliA undecaprenyldiphospho- 3-monooxygenase: RS22920 HMPREF9701_RS03390 HMPREF9701_RS04080 succinyl-CoA muramoylpentapeptide beta-N- tetraacyldisaccharide HMPREF9701_RS12200 (S)-2-oxo-4- a (3R)-3-hydroxydodecanoyl-[acp] a (7Z)-3-[+ 2 isozymes] a 1,2-diacyl- an L-1-phosphatidylethanolamine cob(II)alamin- an apo-["base- (6Z,9Z,12Z,15Z,18Z)-3- D-tagatofuranose 6-O-trans-keto-mycolyl- (S)-4- 4'-kinase: chlorosalicylate degradation glutathione glycyl-glycine a reduced 2[4Fe- + + 7,8-dihydropterin carbonic acid ferroheme o ectoine RS28870 ectoine acetylglucosaminyltransferase: 2,5- oxotetracosapentaenoyl-CoA NAD H 2-oxoadipate 1,6-bisphosphate carboxyphosphinopyruvate phosphoenol hydroxy-4-carboxy- DHAP oxotetradec- sn-glycerol 5-chloro-trans ATP [CblC-CblD off/His-on" 4s] ferredoxin trehalose 6-phosphate dGDP hydroxymandelate 3-hydroxyacyl-[acyl-carrier- HMPREF9701_RS04620 HMPREF9701_RS16510 dihydroxypyridine gamma-glutamyltransferase: acetyl-CoA C- 2-oxoglutarate D-tagatose-bisphosphate carboxyvinyl- pyruvate 5-ureidoimidazoline mandelate racemase/ guanine deaminase: carbonate dehydratase: RS01295 7-enoyl-[acp] 3-phosphate -dienelactone complex] B12-enzyme] ferredoxin--NAD(+) protein] dehydratase FabZ: 5-chlorosalicylate 4-chlorosalicylate cob(I)yrinic acid a,c-diamide HMPREF9701_RS04805 acyltransferase: dehydrogenase aldolase, class II, carboxyphosphonate trehalose-phosphatase: muconate lactonizing HMPREF9701_RS15540 HMPREF9701_RS19060 methylglyoxal synthase: 3-oxoacyl- lipid II (meso diaminopimelate containing) lipid IV 2,5-dihydroxypyridine reductase: pyruvate kinase: OHCU decarboxylase: A carboxymethylenebutenolidase: HMPREF9701_RS02765 RS31175 Cu 2+ RS31740 Cu 2+ HMPREF9701_RS30750 ACP dioxygenase: adenosyltransferase: gamma-glutamyltransferase: HMPREF9701_RS20325 HMPREF9701_RS16000 E1 component: non-catalytic subunit: phosphorylmutase: HMPREF9701_RS06815 HMPREF9701_RS18170 HMPREF9701_RS17885 enzyme family protein: guanine deaminase: carbonic anhydrase: RS26780 HMPREF9701_RS12520 a [cobalamin a holo-["base- reductase HMPREF9701_RS12215 HMPREF9701_RS01330 HMPREF9701_RS17830 [+ 8 isozymes] an oxidized 2[4Fe- HMPREF9701_RS26950 HMPREF9701_RS04905 HMPREF9701_RS16555 HMPREF9701_RS21460 HMPREF9701_RS17720 HMPREF9701_RS24990 salicylate hydroxylase: salicylate hydroxylase: carboxymethylenebutenolidase: a [cyanocobalamin γ-L-glutamyl- (4Z,7Z,10Z,13Z,16Z)- NADH D-glyceraldehyde 3-(hydroxyphosphinoyl) trehalose-trans- dGTP pyruvate 7,8- methylglyoxal ferroheme a a (2E)-dodec-2-enoyl-[acp] a CDP- trafficking triphosphate off/His-on" L-cysteinylglycine acetyl-CoA 4s] ferredoxin glutaryl-CoA NADH CO (S)-(+)-allantoin (R)-4- CO H O FabG: fabG reductase CblC] 2 DHAP keto-mono-mycolate 2 2 diacylglycerol epoxysqualene biosynthesis HMPREF9701_RS18610 HMPREF9701_RS18610 HMPREF9701_RS12025 N-formylmaleamate protein CblD] B12-enzyme] glycylglycine docosapentaenoyl-CoA 3-phosphate pyruvate hydroxymandelate dihydrolumazine hemin RS06310 hemin RS06755 [+ 5 isozymes] vanillin and vanillate salicylate hydroxylase: dodecanoyl-[acyl-carrier- a (3R,7Z)-3- CDP-diacylglycerol-- salicylate hydroxylase: (2E,6E)-farnesyl degradation II HMPREF9701_RS10005 5-chloromaleylacetate N-formylmaleamate protein] reductase: fabG hydroxytetradec- glycerol-3-phosphate 3- HMPREF9701_RS10005 RS28400 diphosphate deformylase: phosphatidylglycerophosphate 4-methyl-3- 1-carboxyvinyl a dimer of non- a 2,3,4-saturated RS06655 7-enoyl-[acp] phosphatidyltransferase: squalene synthase HpnD: (+)-7-epi-jasmonoyl-CoA acetyl-CoA sn-glycerol succinyl-CoA phosphoenol roseoflavin thr D-glycerate meso-tartrate scyllo-inosose AI-2 RS15085 AI-2 vanillin HMPREF9701_RS12210 (1-octadecenoyl(9Z), 2-palmitoyl) a stearoyl-[acp] 4'-phosphopantetheine ATP oxoadipate carboxyphosphonate adjacent 2'- dADP ATP 1,2-diacyl-sn a dodecanoyl-[acp] 3-hydroxyacyl-[acyl- HMPREF9701_RS01990 HMPREF9701_RS15280 ATP cob(II)alamin 3-phosphate hν CTP aldehyde dehydrogenase acetyl-CoA C- glycerol-3-phosphate 1- 3-oxoadipate carboxyvinyl- deoxycytidines pyruvate 5'-phosphate D-glycerate tartrate dehydrogenase: -glycerol 3- carrier-protein] 1-(3-sn- maleamate threonine ammonia-lyase: HMPREF9701_RS17865 inosose isomerase: squalene synthase HpnC: (NAD(+)): phosphatidylglycerophosphatase cob(I)yrinic acid a,c-diamide acyltransferase: O-acyltransferase PlsY: pantetheine-phosphate CoA-transferase: carboxyphosphonate in DNA deoxyribodipyrimidine pyruvate kinase: bifunctional riboflavin dehydrogenase: phosphate RS10900 dehydratase FabZ: phosphatidyl) 3-chlorobenzoate 5-chloro-3-oxoadipate HMPREF9701_RS30030 HMPREF9701_RS18495 fluoride RS16450 fluoride HMPREF9701_RS15275 HMPREF9701_RS30475 A: HMPREF9701_RS23355 adenosyltransferase: HMPREF9701_RS20325 HMPREF9701_RS13410 adenylyltransferase: HMPREF9701_RS10650 phosphorylmutase: photo-lyase: HMPREF9701_RS18170 kinase/FAD synthetase: HMPREF9701_RS23170 tartrate dehydrogenase: beta-ketoacyl-[acyl-carrier- -sn-glycerol degradation III (via gentisate) 1-stearoyl- [+ 3 isozymes] a CDP-2,3,4- HMPREF9701_RS30750 squalene vanillate HMPREF9701_RS01330 [+ 8 isozymes] HMPREF9701_RS12455 HMPREF9701_RS10655 HMPREF9701_RS16555 HMPREF9701_RS04110 HMPREF9701_RS11715 [+ 3 isozymes] HMPREF9701_RS15975 RS02340 protein] synthase I: a (2E,7Z)- 3-phosphate 1-oleoyl-2-palmitoyl- acyl-carrier protein sn-glycerol 3'-dephospho- 4-methyl-3- a 2'-deoxycytidine dATP pyruvate roseoflavin adenine 2-hydroxy-3- 1-keto-D- saturated- RS02355 4-chlorocatechol triphosphate adenosylcobalamin 3-oxo-2-(cis-2'-pentenyl)- succinate carboxyphosphinopyruvate 2-oxobutanoate hydroxypyruvate HMPREF9701_RS24220 tetradeca-2,7- 3-chlorobenzoate phosphatidylglycerol 3-phosphate CoA in DNA dinucleotide chiro-inositol diacylglycerol 2+ 2+ phosphatidylglycerophosphatase vanillate monooxygenase: cyclopentane-1-(3-oxobutanoyl)-CoA oxoadipyl-CoA oxosuccinate Mo RS04385 Mo laurate maleate [+ 2 isozymes] dienoyl-[acp] A: HMPREF9701_RS23355 HMPREF9701_RS20405 cis-∆ 7 - 2-maleylacetate long-chain acyl- an L-1- (3S)-2,3- aromatic ring-hydroxylating RS17240 tetradecenoyl- maleate isomerase: UDP-N-acetyl-α-D-muramoyl- 1-stearoyl- 6-O-cis-keto- a 3-(acyloxy) phosphatidyl- epoxy-2,3- 3-hydroxybenzoate an acyl-[acyl- sn-glycerol 3-methoxy-4- a [protein] (L-serine/L- MoO - (R)-methylmalonyl- an insertion sequence (indol-3-yl) (2R,3S)-3- thiol RS19920 thiol CoA synthetase: dioxygenase subunit alpha: HMPREF9701_RS12205 D-alanyl-D-alanine DL-allothreonine 2 mycolyl-trehalose D-glycerate 3-ethylmalate acyl group of a 3-oxotetradecanoyl-[acp] [acp]:NAD+ sn-glycerol dihydrosqualene 3-chloro-cis,cis-muconate L-alanyl-γ-D-glutamyl-L-lysine sn-glycerol a myristoyl-[acp] hydroxyphenylglycolaldehyde threonine) phosphate molybdopterin ATP CoA element IS30 acetaldehyde isopropylmalate RS25655 HMPREF9701_RS04965 HMPREF9701_RS23830 maleate isomerase: carrier protein] 3-phosphate 6-phosphate RS26490 oxidoreductase: 3-hydroxybenzoate UDP-N-acetylmuramoyl- 3-phosphate1-acyl-sn-glycerol-3- serine glycerol-3-phosphate 1- aldehyde dehydrogenase cofactor transposase: aldehyde dehydrogenase D-glycerate 3-isopropylmalate 3-isopropylmalate bacterial toxin [+ 10 isozymes] 6-hydroxylase: HMPREF9701_RS24110 protein phosphatase CheZ: molybdenum cofactor methylmalonyl-CoA mutase: dehydrogenase: dehydratase: NAD(P)-dependent fabG protocatechuate tripeptide--D-alanyl- phosphate acyltransferase: hydroxymethyltransferase: glyA O-acyltransferase PlsY: (NAD(+)): HMPREF9701_RS32450 (NAD(+)): trehalose-phosphatase: dehydrogenase: HMPREF9701_RS17090 3-oxoadipate HMPREF9701_RS13685 guanylyltransferase MobA: HMPREF9701_RS17295 HMPREF9701_RS23170 HMPREF9701_RS03225 a 3-hydroxyacyl oxidoreductase: lauroyl-CoA a (7Z)-tetradec- fumarate D- alanine ligase: aHMPREF9701_RS04080 1-stearoyl 2- [+ 2 isozymes] HMPREF9701_RS134101-myristoyl- HMPREF9701_RS30475 [+ 3 isozymes] HMPREF9701_RS30475 HMPREF9701_RS06815 HMPREF9701_RS03240 RS08040 adenylyl HMPREF9701_RS30495 an insertion [+ 3 isozymes] HMPREF9701_RS03235 a fatty acid group of RS17250 HMPREF9701_RS12545 7-enoyl-[acp] L-histidine biosynthesis Amino Acid Biosynthesis (2R)-2-chloro-2,5-dihydro- α HMPREF9701_RS04640 acyl-carrier protein acyl-sn-glycerol gly acetaldehyde acyl-carrier protein sn-glycerol trehalose-cis-keto- superpathway of L- L-lysine biosynthesis I L-arginine biosynthesis I (via L-ornithine) L-arginine biosynthesis II (acetyl cycle) superpathway of L- gentisate UDP-N-acetyl- -D-muramoyl-L-alanyl- vanillyl mandelate molybdenum succinyl-CoA sequence IS30 with (indol-3-yl)acetate (2S)-2- 2-oxovalerate bacterial toxin [+ 6 isozymes] phosphatidylglycerol L-glutamate biosynthesis III glycine biosynthesis II 5-oxofuran-2-acetate a [protein] Ser/Thr hydroxypyruvate beta-ketoacyl-[acyl-carrier- isoleucine biosynthesis I L-isoleucine biosynthesis V γ-D-glutamyl-L-lysyl-D-alanyl-D-alanine 3-phosphate 3-phosphate cofactor mono-mycolate isopropylmalate RS13425 biosynthesis II (non-plastidic) threonine biosynthesis integrated transposon RS14830 protein] synthase I: PRPP a [glycine-cleavage N-acetylglutamyl- a (3R)-3-hydroxytetradecanoyl-[acp] 2-oxoglutarate methylsalicylate degradation HMPREF9701_RS24220 DHAP oxaloacetate asp glu gly complex H protein] phosphate N-acetyl-gamma-glutamyl- oxaloacetate 2-methylbutanoate 20 an oxidized ATP NADP-specific glutamate 6 a nascent peptidoglycan with (L- N-acetyl-D-glucosaminyl-N- glycerol-3-phosphate bifunctional aspartate N -lipoyl-L-lysineglycine dehydrogenase bifunctional glutamate phosphate reductase: bifunctional aspartate (indole-3-yl) 1-cis-vaccenoyl-sn- meso- a 5,6-dihydrouracil a double-stranded (R)-10- dCDP RS23565 3-hydroxyacyl-[acyl-carrier- [+ 2 isozymes] aspartate kinase: dehydrogenase: acetate--CoA ligase: 1-stearoyl-sn- γ sn-glycerol glutathione rhodopin (S)-mandelate MeOH O c-type phosphoribosyltransferase aminotransferase/ bifunctional glutamate 2,4- a palmitoyl-[acp] alanyl- -D-glutamyl-meso-2,6- acetylmuramoyl-L-alanyl-D-glutamyl- a palmitoyl-[acp] acetonitrile L-cystathionine in tRNA oligonucleotide Hydroxystearate 2 protein] dehydratase FabZ: a (9Z)-3- dehydrogenase: HMPREF9701_RS23405 (aminomethyl-transferring) N-acetyltransferase/ HMPREF9701_RS21535 aminotransferase/ 2-maleylacetate protoanemonin 5-methylsalicylate glycerol 3-phosphate 3-phosphate glycerol-3-phosphate diaminopimelate ribonucleoside- cytochrome regulatory subunit: HMPREF9701_RS02755 L-tryptophan biosynthesis HMPREF9701_RS01090 dihydroxybenzoate diaminopimeloyl-D-alanine) tetrapeptide 6-carboxy-L-lysyl-D-alanine glutathione S-transferase: oleate hydratase: mandelate racemase/ cytochrome oxohexadec- HMPREF9701_RS12385 L-aspartate beta- N-acetyltransferase/ : HMPREF9701_RS21710 amino-acid acetylglutamate kinase: L-aspartate beta- 2-methylbutanoyl- 1-acyl-sn-glycerol-3- muramoyltetrapeptide muramoyltetrapeptide glycerol-3-phosphate 1- cystathionine beta-lyase: 1-acyl-sn-glycerol-3- tRNA dihydrouridine(20/ diphosphate reductase: c oxidase a reduced HMPREF9701_RS30750 N-acetyl-gamma-glutamyl- HMPREF9701_RS03980 carotenoid 1,2-hydratase: diaminopimelate oligoribonuclease: HMPREF9701_RS11060 muconate lactonizing catalase: RS17440 9-enoyl-[acp] sn-glycerol HMPREF9701_RS31145 decarboxylase: L-aspartyl-4-phosphate amino-acid glu CO HMPREF9701_RS23985 decarboxylase: CoA phosphate acyltransferase: carboxypeptidase: carboxypeptidase: O-acyltransferase PlsY: HMPREF9701_RS28830 phosphate acyltransferase: 20a) synthase DusA: HMPREF9701_RS04470 H O c-type RS21495 2 acetyltransferase ArgJ: phosphate reductase: HMPREF9701_RS02840 dehydrogenase: HMPREF9701_RS11950 HMPREF9701_RS21350 2 3-phosphate salicylate hydroxylase: salicylate hydroxylase: HMPREF9701_RS13325 HMPREF9701_RS13325 [+ 8 isozymes] [+ 2 isozymes] HMPREF9701_RS16750 oleate hydratase: enzyme family protein: cytochrome a (2E)-tetradec-2-enoyl-[acp] NAD(P)-dependent ATP HMPREF9701_RS28225 acetyltransferase ArgJ: HMPREF9701_RS10945 HMPREF9701_RS14295 chorismate HMPREF9701_RS28225 HMPREF9701_RS04080 a nascent peptidoglycan with N-acetyl-D-glucosaminyl-N- HMPREF9701_RS134101-palmitoyl- (glutathion-S- HMPREF9701_RS04080 HMPREF9701_RS04475 HMPREF9701_RS18610 HMPREF9701_RS18610 1-stearoyl-2-palmitoyl- HMPREF9701_RS23055 HMPREF9701_RS05660 HMPREF9701_RS21460 oxidoreductase: glycerol-3-phosphate 1- phosphoribosyltransferase: [+ 3 isozymes] aspartate-semialdehyde HMPREF9701_RS10945 acyl-carrier protein D-ala (L-alanyl-γ-D-glutamyl-meso- D-ala acetylmuramoyl-L-alanyl-D- acyl-carrier protein sn-glycerol yl)(1H-indol-3- pyruvate L-homocysteine 1,2-dicis-vaccenoyl- 1,1'-dihydroxy-1,1',2,2'- a nucleoside 5'- RS30690 RS00655 superpathway of L-methionine biosynthesis (by sulfhydrylation) amino-acid N- [+ 3 isozymes] (S)-2,3,4,5- a uracil 20 in tRNA formaldehyde CDP HMPREF9701_RS12545 HMPREF9701_RS10830 dehydrogenase: amino-acid N- anthranilate synthase: 3-oxoadipate salicylate hydroxylase: salicylate hydroxylase: sn-glycerol 3-phosphate 2,6-diaminopimelate) tripeptide glutamyl-6-carboxy-L-lysine yl)acetonitrile phosphatidate tetrahydrolycopene monophosphate oleate (R)-mandelate myristoyl-[acyl-carrier- O-acyltransferase PlsY: asp asp 3-phosphate tetrahydrodipicolinate HMPREF9701_RS03245 acetyltransferase: HMPREF9701_RS14985 (S)-3-methyl-2- HMPREF9701_RS10005 HMPREF9701_RS10005 [+ 6 isozymes] HMPREF9701_RS13410 1-(5-phospho- acetyltransferase: protein] reductase: fabG oxaloacetate HMPREF9701_RS05810 a (3R,9Z)-3- a 1-acyl-sn β L-aspartate- HMPREF9701_RS05810 glu N-acetyl-L-glutamate oxopentanoate RS26580 -D-ribosyl)-ATP aspartate kinase: N-acetyl-L-glutamate anthranilate RS25190 hydroxyhexadec- -glycerol 3- semialdehyde 5-semialdehyde aspartate kinase: branched-chain amino 1-myristoyl- 10 UDP a myristoyl-[acp] phosphoribosyl-ATP bifunctional aspartate 4-methylcatechol 1-stearoyl-sn- a cis- sn-glycerol 4a-hydroxy-N - O-succinyl-L- a medium-chain 2,3,4- an L-1- 9-enoyl-[acp] phosphate HMPREF9701_RS23405 N-acetyl-L- HMPREF9701_RS23405 acid transaminase: a stearoyl-[acp] a myristoyl-[acp] sn-glycerol pimeloyl-CoA ala 4-acetamidobutanal lipid A uroporphyrinogen-III Ins(2)P ethylphosphate [DNA] ethanol anthranilate formyltetrahydrofolate saturated fatty acyl CoA phosphatidylethanolamine ribonucleoside- RS21630 RS30905 3-hydroxyacyl-[acyl- 1-acyl-sn-glycerol-3- diphosphatase: 4-hydroxy- glutamate aminotransferase/ glycerol 3-phosphate vaccenoyl-[acp] 3-phosphate homoserine HMPREF9701_RS07820 1-acyl-sn-glycerol-3- 3-phosphate1-acyl-sn-glycerol-3- glycerol-3-phosphate 1- 4a-hydroxytetrahydrobiopterin 8-amino-7- O-succinylhomoserine acyl-CoA dehydrogenase: aldehyde dehydrogenase uroporphyrinogen-III DNA polymerase beta-ketoacyl-[acyl-carrier- phosphate acyltransferase: HMPREF9701_RS10710 L-aspartyl- tetrahydrodipicolinate superpathway of branched chain amino acid biosynthesis L-aspartate beta- phosphoribosyltransferase: L-aspartyl- Amine and Polyamine Degradation alkaline phosphatase D: catalase: diphosphate reductase: carrier-protein] phosphate acyltransferase: phosphate acyltransferase: O-acyltransferase PlsY: dehydratase: sulfhydrylase: HMPREF9701_RS23335 (NAD(+)): C-methyltransferase: inositol monophosphatase: III subunit epsilon: protein] synthase I: 1-(5-phospho-β- 4-phosphate synthase: acetylglutamate kinase: decarboxylase: HMPREF9701_RS14990 oxononanoate synthase: lipid A 4'-(2- HMPREF9701_RS28825 HMPREF9701_RS04470 dehydratase FabZ: HMPREF9701_RS04080 N-acetylornithine 4-phosphate ile HMPREF9701_RS15635 HMPREF9701_RS28625 HMPREF9701_RS21350 HMPREF9701_RS24220 a 1,2-diacyl- HMPREF9701_RS23985 HMPREF9701_RS28225 HMPREF9701_RS04080 1,2-dimyristoyl-HMPREF9701_RS04080 HMPREF9701_RS134101-cis-vaccenoyl- HMPREF9701_RS11940 HMPREF9701_RS12310 HMPREF9701_RS13515 [+ 18 isozymes] HMPREF9701_RS30475 aminoethyl HMPREF9701_RS15940 [+ 3 isozymes] HMPREF9701_RS04475 RS05040 HMPREF9701_RS30750 D-ribosyl)-AMP HMPREF9701_RS02500 aminotransferase: N-(5-phosphoribosyl) creatinine degradation II 1-stearoyl-2-stearoyl-sn 8-amino-7- a 1,2-diacyl- RS16330 aspartate-semialdehyde pyruvate thr aspartate-semialdehyde creatinine degradation I 4-aminobutanoate degradation I an N 10 -formyl- coenzyme A a medium-chain trans- a nucleoside 5'- [+ 2 isozymes] a (2E,9Z)- sn-glycerol [+ 3 isozymes] gln HMPREF9701_RS09895 -anthranilate allantoin degradation 4-aminobutanoate degradation III acyl-carrier protein acyl-carrier protein sn-glycerol acyl-carrier protein sn-glycerol- succinate L-homocysteine 4-acetamidobutanoate diphosphate) sn-glycerol precorrin-2 acetaldehyde dUDP phosphoribosyl- dehydrogenase: 4-hydroxy- N-acetylglutamyl- dehydrogenase: -glycerol 3-phosphate oxononanoate myo-inositol ethanol RS11815 hexadeca-2,9- 3-phosphate to glyoxylate I 3-phosphate 3-phosphate 7,8-dihydrofolate 2,3-dehydroacyl-CoA (E. coli) monophosphate AMP HMPREF9701_RS03245 tetrahydrodipicolinate phosphate acetolactate synthase: phosphoribosylanthranilate creatinine RS08235 a 3-oxohexadecanoyl-[acp] threonine ammonia-lyase: carbamoyl-phosphate HMPREF9701_RS03245 dienoyl-[acp] cyclohydrolase: synthase: HMPREF9701_RS30395 asp isomerase: creatinine 4-aminobutanoate 4-aminobutanoate L-aspartate- N-acetyl-gamma-glutamyl- HMPREF9701_RS30030 (S)-(+)-allantoin HMPREF9701_RS30400 synthase: carB L-aspartate- creatininase: 4-aminobutyrate--2- 4-aminobutyrate--2- hisI HMPREF9701_RS03115 phosphate reductase: N-acetyl-L-ornithine HMPREF9701_RS03260 (2S,3S)-2,3- (6R)-L-erythro 6-O-α-mycolyl- NAD(P)-dependent β semialdehyde (2S,4S)-4- [+ 3 isozymes] HMPREF9701_RS30725 semialdehyde allantoinase PuuE: oxoglutarate transaminase: an odd numbered straight chain a long-chain 2,3,4- an L-1- D-glyceraldehyde 1-(5-phospho- -D-ribosyl)- aspartate kinase: bifunctional glutamate 1-(o-carboxyphenylamino)-1'- HMPREF9701_RS13625 oxoglutarate transaminase: 1-palmitoyl-sn- aci-nitroethane dihydroxy-5- a PII protein UTP lipid A Ins(1)P decanoyl-CoA trehalose 6- an aryl sulfate a phosphatidylcholine RS11465 oxidoreductase: a CDP- HMPREF9701_RS21535 (S)-2-acetolactate N-methylhydantoin HMPREF9701_RS17880 a palmitoleoyl-[acp] a pimeloyl-[acp] ala 2,3,4-saturated fatty aldehyde -5,6,7,8- phe saturated fatty acyl CoA phosphatidylethanolamine 3-phosphate RS06410 5-[(5-phosphoribosylamino) homoserine hydroxy-2,3,4,5- (2Z)-2-aminobut- HMPREF9701_RS23405 N-acetyltransferase/ deoxyribulose 5'-phosphate homoserine HMPREF9701_RS31340 HMPREF9701_RS31340 glycerol 3-phosphate HMPREF9701_RS12545 diacylglycerol carbamoyl phosphate L-ornithine creatine 1-acyl-sn-glycerol-3- nitronate monooxygenase: 8-amino-7- aldehyde dehydrogenase oxohexanedioate tetrahydrobiopterin phenylalanine 4- acyl-CoA dehydrogenase: [protein-PII] aldehyde dehydrogenase acyl-CoA dehydrogenase: phosphate RS12875 methylideneamino]imidazole- dehydrogenase: tetrahydrodipicolinate N-acetyl-gamma-glutamyl- 2-enoate amino-acid allantoate succinate semialdehyde succinate semialdehyde alpha-dehydro-beta-deoxy- a palmitoleoyl-[acp] ketol-acid indole-3-glycerol dehydrogenase: N-methylhydantoinase B: phosphate acyltransferase: HMPREF9701_RS20625 oxononanoate synthase: (NAD(+)): monooxygenase: HMPREF9701_RS23335 uridylyltransferase: (NAD(+)): inositol monophosphatase: HMPREF9701_RS23335 trehalose-phosphatase: sulfatase: RS20975 [+ 6 isozymes] CDP-diacylglycerol-- 4-carboxamide HMPREF9701_RS03145 4-hydroxy- phosphate reductase: acetyltransferase ArgJ: D-glucarate aldolase: lipid A 1-(2- a 2-acyl-sn reductoisomerase: L-aspartyl- phosphate HMPREF9701_RS03145 NAD-dependent HMPREF9701_RS04080 [+ 2 isozymes] HMPREF9701_RS12310 HMPREF9701_RS30475 HMPREF9701_RS24255 HMPREF9701_RS27470 HMPREF9701_RS30475 HMPREF9701_RS15635 HMPREF9701_RS06815 HMPREF9701_RS08045 glycerol-3-phosphate 3- HMPREF9701_RS14295 HMPREF9701_RS10945 HMPREF9701_RS10260 succinate-semialdehyde 1-palmitoyl-2- [unspecified HMPREF9701_RS29950 [+ 18 isozymes] aminoethyl a 1,2-diacyl- [+ 18 isozymes] a fatty acid -glycero-3- 1-(5-phosphoribosyl)-5- tetrahydrodipicolinate HMPREF9701_RS30390 4-phosphate L-lysine biosynthesis III 8-amino-7- tartronate (6R)-6,7- a uridylylated a (3R)-3-hydroxyhexadecanoyl-[acp] phosphatidyltransferase: L-homoserine N-acetyl-L- synthase succinate-semialdehyde acyl-carrier protein palmitoleoyl-sn- degradation nitrite acetaldehyde acyl-carrier protein an odd numbered straight pyruvate tyr a long-chain trans- 3-phospho- (2E)-dec-2- α α [(5- phosphoribosylamino) reductase: (2R)-2,3- L-homoserine dehydrogenase: gabD putrescine degradation I semialdehyde diphosphate) sn-glycerol myo-inositol , '-trehalose a phenol phosphocholine HMPREF9701_RS01990 glutamate 5- aspartate-semialdehyde TrpC: trpC N-carbamoylsarcosine dehydrogenase: gabD oxononanoate chain 2,3,4-saturated fatty acid dihydrobiopterin 2,3-dehydroacyl-CoA PII protein D-glycerate enoyl-CoA RS26900 methylideneamino]imidazole- HMPREF9701_RS29245 2-iminobutanoate glycerol 3-phosphate products] (E. coli) 6-α-mycolate RS17220 3-hydroxyacyl-[acyl-carrier- 1-(3-sn- semialdehyde dihydroxy-3- RS24535 4- carboxamide isomerase: homoserine kinase: dehydrogenase: ornithine (1S,2R)-1-C-(indol-3- sarcosine (S)-ureidoglycolate [+ 3 isozymes] succinate protein] dehydratase FabZ: palmitoleate phosphatidyl) (S)-2,3,4,5- N-acetylornithine methylbutanoate asp homoserine kinase: putrescine HMPREF9701_RS10865 HMPREF9701_RS12010 HMPREF9701_RS03245 carbamoyltransferase: yl)glycerol 3-phosphate RS09415 HMPREF9701_RS30750 -sn-glycerol tetrahydrodipicolinate aminotransferase: dihydroxy-acid aspartate kinase: HMPREF9701_RS12010 succinate HMPREF9701_RS09900 ureidoglycolate lyase: 1-cis-vaccenoyl- salicyl-6-hydroxy-2- a single- a 2-methyl branched 2,3,4- a very-long-chain 2,3,4- 2-(4-hydroxyphenyl) Kdo CTP L-gulono- 1-palmitoyl-2-linoleoyl- imidazole glycerol 2,3,4,5-tetrahydropyridine- HMPREF9701_RS09895 dehydratase: L-aspartate- tryptophan synthase: 1-cis-vaccenoyl-sn- a cis- 3,4-dihydroxyphenylglycolaldehyde (2E)-hexadecenal myristoyl-CoA propionamide 3-phosphate O-phospho- HMPREF9701_RS23405 O-phospho- HMPREF9701_RS31480 a palmitoleoyl-[acp] sn-glycerol- cyclohexene-on-oyl stranded RNA saturated fatty aldehyde saturated fatty acyl CoA -2-oxoacetate ATP an mRNA 1,4-lactone phosphatidylcholine a (2E)-hexadec-2-enoyl-[acp] HMPREF9701_RS20160 semialdehyde HMPREF9701_RS03265 glycerol-3-phosphate vaccenoyl-[acp] phosphate synthase L-homoserine 2,6-dicarboxylate N- 2-oxobutanoate L-aspartyl- L-homoserine urea degradation I 4-aminobutanal 3-phosphate aldehyde dehydrogenase carboxylesterase: polyribonucleotide acyl-CoA dehydrogenase: aldehyde dehydrogenase 3-deoxy-manno- acyl-CoA dehydrogenase: SMP-30/gluconolactonase/ amidase: phosphatidylglycerophosphatase N-acetyl-L- HMPREF9701_RS03270 sarcosine 1-acyl-sn-glycerol-3- 1-acyl-sn-glycerol-3- aldehyde dehydrogenase benzoylformate cyclase subunit: succinyltransferase: hydrogencarbonate 3-methyl-2- homoserine 4-phosphate glyoxylate HMPREF9701_RS30100 nucleotidyltransferase: polynucleotide octulosonate LRE family protein: RS12725 RS24280 RS05845 A: HMPREF9701_RS23355 ornithine phosphate acyltransferase: phosphate acyltransferase: (NAD(+)): (NAD(+)): HMPREF9701_RS23335 decarboxylase: (NAD(+)): HMPREF9701_RS23335 HMPREF9701_RS20375 1-linoleoyl- HMPREF9701_RS10720 threonine synthase: HMPREF9701_RS16725 oxobutanoate acetolactate synthase: dehydrogenase: [+ 2 isozymes] threonine synthase: gly gamma-aminobutyraldehyde [+ 2 isozymes] HMPREF9701_RS02970 adenylyltransferase PcnB: cytidylyltransferase: HMPREF9701_RS21285 an L-1- 1-cis-vaccenoyl-HMPREF9701_RS04080 HMPREF9701_RS040801,2-dicis- HMPREF9701_RS30475 6-hydroxy-2- HMPREF9701_RS30475 [+ 18 isozymes] HMPREF9701_RS04255 HMPREF9701_RS30475 [+ 18 isozymes] [+ 3 isozymes] palmitate sn-glycero-3- (Kdo) -lipid A biosynthesis I HMPREF9701_RS03140 carbamoyl-phosphate acetylornithine HMPREF9701_RS03145 aspartate-semialdehyde urea dehydrogenase: a nucleoside a single- HMPREF9701_RS09850 HMPREF9701_RS16500 2 phosphatidyl- phosphoribulosylformimino- N-succinyl-2-amino- HMPREF9701_RS30395 ser HMPREF9701_RS03140 urea degradation II a 2-methyl branched a very-long-chain trans (2E)- 2E)-tetradec- [+ 2 isozymes] RS25640 synthase: carB deacetylase: L-citrulline dehydrogenase: indole HMPREF9701_RS02425 acyl-carrier protein 2-palmitoleoyl-sn- acyl-carrier protein vaccenoyl- 3,4-dihydroxymandelate salicyl alcohol cyclohexen- diphosphate stranded RNA 4-hydroxybenzaldehyde an mRNA propanoate phosphocholine 6-ketopimelate 2-isopropylmalate branched-chain amino HMPREF9701_RS30400 2,3,4-saturated fatty acid -2,3-dehydroacyl-CoA hexadecenoate CMP-Kdo 2-enoyl-CoA L-gulonate α-Kdo-(2->4)-α- sn-glycerol AICAR-phosphate HMPREF9701_RS08340 HMPREF9701_RS03245 glycerol-3-phosphate phosphatidate one-carboxylate thr HMPREF9701_RS30725 synthase: acid transaminase: L-homoserine thr a palmitoyl-[acp] Kdo-(2->6)-lipid IV succinyldiaminopimelate (S)-2-aceto-2- 4-aminobutanoate lipid A biosynthesisA HMPREF9701_RS03605 HMPREF9701_RS07820 argininosuccinate synthase: L-aspartate- gly urea urea-1-carboxylate transaminase: carbamoyl hydroxybutanoate tryptophan synthase RS05410 RS15460 RS05875 imidazole glycerol L-ornithine homoserine O- HMPREF9701_RS13475 semialdehyde urease: lauroyl acyltransferase: threonine ammonia-lyase: HMPREF9701_RS16730 phosphate [+ 2 isozymes] ketol-acid subunit beta: L-cysteine biosynthesis 1-palmitoyl- a dimer of adjacent a 2'- phosphate synthase acetyltransferase: HMPREF9701_RS24625 1-myristoyl-sn- a cis- an L-phenylalanyl- an N-terminal a reduced [2Fe- γ HMPREF9701_RS10450 HMPREF9701_RS30030 HMPREF9701_RS03265 VI (from L-methionine) allophanate hydrolase: a palmitoleoyl-[acp] sn-glycerol NAD + H + thymidine and 2'- hν dihydrolipoamide chlorobactene 2-hydroxyisobutyramide 2,2-dichloroacetate rhodopin a DNA segment wound RNA an aldehyde -carotene deoxyribonucleoside [DNA] α-Kdo-(2->4)-α-Kdo- N-succinyl-L,L-2,6- reductoisomerase: 4-hydroxy- Phe RS03465 subunit HisH: val HMPREF9701_RS29425 L-arginino-succinate HMPREF9701_RS24635 HMPREF9701_RS08700 glycerol 3-phosphate vaccenoyl-[acp] [tRNA ] arginyl-[protein] 2S] ferredoxin (2->6)-(lauroyl)-lipid IV [+ 3 isozymes] diaminopimelate ornithine (2S)-2- HMPREF9701_RS30390 tetrahydrodipicolinate tryptophan synthase 1-acyl-sn-glycerol-3- 3-phosphate1-acyl-sn-glycerol-3- leucyl/phenylalanyl-tRNA- ferredoxin--NAD(+) deoxycytidine in DNAdeoxyribodipyrimidine dihydrolipoyllysine- amidase: glutathione S-transferase: ATP-dependent aldehyde dehydrogenase 5'-triphosphate A HMPREF9701_RS10860 HMPREF9701_RS24640 recombinase RecA: long-chain fatty (2Z)-2-aminobut- isopropylmalate O-acetyl-L- -protein transferase: reductase: carotenoid 1,2-hydratase: HMPREF9701_RS03980 carotenoid 1,2-hydratase: RNA helicase DbpA: (NAD(+)): carotenoid 1,2-hydratase: palmitate lipid A biosynthesis succinyl-diaminopimelate carbamoyltransferase: (R)-2,3-dihydroxy- argininosuccinate lyase: synthase: subunit beta: met ammonium ammonium phosphate acyltransferase: phosphate acyltransferase: photo-lyase: residue acetyltransferase: HMPREF9701_RS20375 acid activation imidazole glycerol 2-enoate homoserine hydrogen sulfide methionine HMPREF9701_RS02840 HMPREF9701_RS02840 HMPREF9701_RS14315 HMPREF9701_RS22255 HMPREF9701_RS02840 acyltransferase: desuccinylase: HMPREF9701_RS09900 3-isopropylmalate 3-methylpentanoate HMPREF9701_RS12065 HMPREF9701_RS02500 HMPREF9701_RS17020 1-myristoyl-2-HMPREF9701_RS04080 1-palmitoyl-2-HMPREF9701_RS04080 HMPREF9701_RS30355 HMPREF9701_RS16000 HMPREF9701_RS04110 HMPREF9701_RS28535 [+ 3 isozymes] [+ 8 isozymes] HMPREF9701_RS30475 [DNA] RS06945 RS26365 long-chain acyl- phosphate synthase L-phenylalanyl-L- an oxidized [2Fe- adjacent thymidine-2'- RS09400 HMPREF9701_RS10445 a long-chain HMPREF9701_RS16715 dehydratase: adenosyltransferase: acyl-carrier protein palmitoleoyl-sn- acyl-carrier protein cis-vaccenoyl a tRNA Phe NADH 2-hydroxy-2- a DNA segment in 1'-hydroxy- cyclase subunit: dihydroxy-acid 4-hydroxy- deoxycytidine in DNA S-acetyldihydrolipoamide 1-hydroxychlorobactene glyoxylate all-trans-lycopene an unwound RNA a carboxylate CoA synthetase: α α fatty acid HMPREF9701_RS03225 HMPREF9701_RS10440 arginyl-[protein] 2S] ferredoxin methylpropanoate reverse orientation γ-carotene -D-Kdo-(2->4)- - fatty acid--CoA ligase: dehydratase: O-acetylhomoserine arg tetrahydrodipicolinate glycerol 3-phosphate phosphatidate HMPREF9701_RS04965 HMPREF9701_RS10720 L-citrulline HMPREF9701_RS03235 trp SAM RS32000 D-Kdo-(2->6)-lipid A HMPREF9701_RS21695 L,L-diaminopimelate HMPREF9701_RS20160 (thiol)-lyase: synthase: [+ 10 isozymes] 2-iminobutanoate [+ 10 isozymes] D-erythro- 2-isopropylmaleate (S)-3-methyl-2- HMPREF9701_RS30875 HMPREF9701_RS03115 1-palmitoyl- an [L-cysteine a long-chain diaminopimelate (2S,4S)-4- Carbohydrate Degradation an L-phenylalanyl- a cytosine 32 2-hydroxychromene- (7Z)- 7,8- (R)-propane- dCTP RS07535 palmitoyl-CoA AICAR imidazole-glycerol- argininosuccinate synthase: O-acetylhomoserine a 2,3,4-saturated a 2,3,4-saturated 2- an N-terminal desulfurase]-S- an oxidized c- 1-hydroxyneurosporene 3-methylmuconolactone perillyl aldehyde coniferaldehyde decanal oxopentanoate Nucleoside and Nucleotide Degradation sn-glycerol a myristoyl-[acp] Phe (R)-lactate 2-carboxylate tetradecenoyl-CoA diaminopelargonate 1,2-diol RS30765 fatty acyl-CoA phosphate epimerase: HMPREF9701_RS13475 hydroxy-2,3,4,5- fatty acyl-[acp] lysophosphatidate [tRNA ] L-lysyl-[protein] in tRNA type cytochrome RS07140 3-isopropylmalate branched-chain amino aminocarboxypropyltransferase/ 1-acyl-sn-glycerol-3- 3-phosphate 1-acyl-sn-glycerol-3- leucyl/phenylalanyl-tRNA- sulfanyl-L-cysteine tRNA 2-thiocytidine(32) 2-hydroxychromene-2- muconolactone acyl-CoA dehydrogenase: aldehyde dehydrogenase NAD(P)-dependent coniferyl-aldehyde aldehyde dehydrogenase dCTP deaminase: HMPREF9701_RS04705 tetrahydrodipicolinate chitin degradation II (Vibrio) FAD-binding protein: carotenoid 1,2-hydratase: dethiobiotin synthase: imidazoleglycerol- L-arginino- dehydratase: acid transaminase: cysteine synthase: D-mannose degradation phosphate acyltransferase: phosphate acyltransferase: -protein transferase: synthetase TtcA: carboxylate isomerase: delta-isomerase: HMPREF9701_RS20295 (NAD(+)): alcohol dehydrogenase: dehydrogenase: (NAD(+)): HMPREF9701_RS17715selenate RS26540 selenate phosphate HMPREF9701_RS03225 HMPREF9701_RS10345 4-hydroxy- SAH purine nucleotides degradation II (aerobic) HMPREF9701_RS29765 HMPREF9701_RS02840 HMPREF9701_RS12305 2-oxobutanoate meso-diaminopimelate succinate HMPREF9701_RS07820 S-methyl-5'-thioadenosine HMPREF9701_RS04080 HMPREF9701_RS04080 HMPREF9701_RS30355 HMPREF9701_RS24360 HMPREF9701_RS11850 HMPREF9701_RS12135 HMPREF9701_RS30475 HMPREF9701_RS07550 HMPREF9701_RS03075 HMPREF9701_RS30475 tetrahydrodipicolinate a 2,3,4-saturated 1-palmitoyl- 32 an [L-cysteine a reduced c- [+ 18 isozymes] dehydratase HisB: HMPREF9701_RS03235 chitin D-mannopyranose thymine degradation degradation IV L-phenylalanyl- a 2-thiocytosine pyruvate dUTP argininosuccinate lyase: reductase: 5'-methylthioadenosine/ acyl-carrier protein 1,2-diacyl-sn- acyl-carrier protein 2-myristoyl a tRNA Phe desulfurase]- type cytochrome trans-O- 1,1'-dihydroxy- 4-methyl-3-oxoadipate- (2E,7Z)- RS20560 HMPREF9701_RS10855 acetolactate synthase: diaminopimelate (2R,3S)-3- ile 6-phosphate L-lysyl-[protein] in tRNA dethiobiotin perillate (R)-lactaldehyde ferulate decanoate HMPREF9701_RS12065 HMPREF9701_RS29245 adenosylhomocysteine mannose-1-phosphate thymine S-methyl-5'- glycerol 3-phosphate phosphatidate L-cysteine hydroxybenzylidenepyruvate neurosporene enol-lactone tetradecenoyl-CoA nitrate RS25025 nitrate HMPREF9701_RS30395 isopropylmalate ATP L-homocysteine AMP imidazole acetol- decarboxylase: guanylyltransferase/ thioadenosine HMPREF9701_RS30400 (S)-2,3,4,5- nucleosidase: dihydrothymine 5'-methylthioadenosine/ phosphate HMPREF9701_RS12380 3-isopropylmalate APS arg methionine synthase: methionine synthase: tetrahydrodipicolinate HMPREF9701_RS18040 mannose-6- bifunctional dehydrogenase: (S)-2-aceto-2- dehydrogenase: a chitodextrin adenosylhomocysteine 3-aci- 1-palmitoyl- an N-terminal 4-hydroxy- (5Z)- (5Z)- a monocarboxylic 3-[(6'-methylthio) CTP histidinol-phosphate sulfate adenylyltransferase: HMPREF9701_RS21610 HMPREF9701_RS08365 phosphate isomerase: HMPREF9701_RS01635 isobutanoate ferulate an L-arginyl- glutathione 1-hydroxyneurosporene carbamoyl lauroyl-CoA an alcohol lys S-ribosyl-L- metallophosphatase/ nucleosidase: nitropropanoate a palmitoyl-[acp] sn-glycerol Arg 3-sulfino-L- 2-nonenal asp tetradecenoyl-CoA dodecenoyl-CoA acid amide hexyl]malate aminotransferase: hydroxybutanoate HMPREF9701_RS03240 adenylyl-sulfate kinase: HMPREF9701_RS06455 HMPREF9701_RS10410 [tRNA ] phosphate predicted Amine and Polyamine Biosynthesis [+ 2 isozymes] [+ 2 isozymes] homocysteine 5'-nucleotidase: 5,6-dihydrothymine HMPREF9701_RS18040 nitronate monooxygenase: 3-phosphate acetate--CoA ligase: feruloyl-CoA synthase: alanyl-[protein] glutathione S-transferase: dCTP deaminase: RS04815 ketol-acid (2S)-2-isopropyl- HMPREF9701_RS25295 1-acyl-sn-glycerol-3- arginyltransferase: aspartate acyl-CoA dehydrogenase: acyl-CoA dehydrogenase: amidase: 3-isopropylmalate acyl-CoA dehydrogenase: NAD(P)-dependent ABC HMPREF9701_RS01345 superpathway of L-serine HMPREF9701_RS06460 F6P HMPREF9701_RS08690 GMP MTR HMPREF9701_RS20625 HMPREF9701_RS01090 HMPREF9701_RS30045 HMPREF9701_RS03980 carotenoid 1,2-hydratase: HMPREF9701_RS17715 nitrate nitrate reductoisomerase: 3-oxosuccinate dihydropyrimidinase: phosphate acyltransferase: HMPREF9701_RS30360 carbamoyltransferase: HMPREF9701_RS20295 HMPREF9701_RS20295 HMPREF9701_RS20375 dehydrogenase: HMPREF9701_RS23335 alcohol dehydrogenase: transporter [+ 2 isozymes] and glycine biosynthesis I met L-α-amino-ε- [+ 2 isozymes] an N-terminal L- [+ 8 isozymes] HMPREF9701_RS02840 spermidine biosynthesis III HMPREF9701_RS30390 PAPS APS 5'-nucleotidase: HMPREF9701_RS01645 [unspecified HMPREF9701_RS04080 (glutathion-S- HMPREF9701_RS04090 [+ 18 isozymes] [+ 18 isozymes] [+ 3 isozymes] HMPREF9701_RS03240 [+ 18 isozymes] HMPREF9701_RS07550 of nitrate putrescine biosynthesis I superpathway of sulfate assimilation and cysteine biosynthesis uracil degradation I (reductive) keto-pimelate a chitodextrin bifunctional dipalmitoyl diphosphate arginiyl-3-sulfino- a tRNA Arg N-carbamoyl- UTP L-histidinol 3-phospho- HMPREF9701_RS08585 hydantoinase/oxoprolinase degradation 3-oxopropanoate isobutanoyl-CoA AMP diphosphate AMP feruloyl-CoA yl)-4-hydroxy- all-trans (2E,5Z)- (2E,5Z)- 9-(methylthio)- (2E)-dodec- (R)-2,3-dihydroxy- IMP nitrite acyl-carrier protein a monocarboxylate an aldehyde phosphate diaminopimelate fructose degradation metallophosphatase/ phosphatidate L-alanyl-[protein] L-aspartate 2+ Co 2+ 3-methylpentanoate 3-phospho- D-glycerateD-3-phosphoglycerate family protein: products] 2-nonenal neurosporene tetradecenoyl-CoA dodecenoyl-CoA 2-oxononanoate 2-enoyl-CoA Co RS22125 arg SAM uracil L-homocysteine 5'-nucleotidase: 2+ 2+ RS10365 arg 4-methyl-2- dehydrogenase: adenosine HMPREF9701_RS10255 Mg Mg dihydroxy-acid D-glycerate dehydrogenase: dihydropyrimidine β HMPREF9701_RS08690 oxopentanoate HMPREF9701_RS23055 -D-fructofuranose IMP dehydrogenase: arginine decarboxylase, dehydratase: D-3-phosphoglycerate HMPREF9701_RS21390 dehydrogenase: 3-(carbamoylamino)- 1-stearoyl- cyclic a thiocarboxylated an N-terminal a 2'- arginine decarboxylase, L-proline biosynthesis I L-arginine degradation 1-phosphate 10 3-[(5'-methylthio) 7,8-dihydro- branched-chain amino L-phenylalanine biosynthesis I 5'-nucleotidase: HMPREF9701_RS09270 an N - an L-methionyl- isovalerate an L-arginyl- phosphonoacetaldehyde 4-guanidinobutyramide cis-vaccenoyl-CoA a 7,8-dihydrofolate (R)-lactaldehyde dodecanal a colanic acid lipid A-core biosynthetic: HMPREF9701_RS20160 dehydrogenase: [+ 3 isozymes] HMPREF9701_RS01635 meso- beta-N- 1-phosphofructokinase: adenosine deaminase: 2-methylpropanoate an oleoyl-[acp] sn-glycerol pyranopterin [SAMP] C- 3-sulfo-L- deoxyribonucleoside [DNA] 2+ 2+ biosynthetic: I (arginase pathway) HMPREF9701_RS08585 formyltetrahydrofolate [initiator tRNA Met ] [tRNA Arg ] pentyl]malate 8-oxoguanine Co Co HMPREF9701_RS09460 histidinol HMPREF9701_RS21390 acid transaminase: 3-phosphooxypyruvate diaminopimelate 5'-triphosphate RS12695 HMPREF9701_RS09460 (S)-3-methyl-2- acetylhexosaminidase: β HMPREF9701_RS01060 HMPREF9701_RS17735 3-phosphate1-acyl-sn-glycerol-3- methionyl-tRNA acetate--CoA ligase: phosphate terminalmolybdopterin glycine synthase alanyl-[protein] DNA polymerase IV: phosphonoacetaldehyde amidase: acyl-CoA dehydrogenase: aldehyde dehydrogenase 3-isopropylmalate aldehyde dehydrogenase Mg 2+ Mg 2+ agmatine HMPREF9701_RS07820 5,6-dihydrouracil -D-fructose 1,6- arginyltransferase: dihydrofolate reductase: 8-oxoguanine deaminase: dAdoMet [+ 3 isozymes] glu chorismate diaminopimelate N,N'- HMPREF9701_RS03330 N,N',N''- XMP phosphate acyltransferase: formyltransferase: HMPREF9701_RS01090 HMPREF9701_RS03575 hydrolase: HMPREF9701_RS20375 HMPREF9701_RS20295 (NAD(+)): dehydrogenase: (NAD(+)): RS04895 histidinol dehydrogenase: oxopentanoate 3-phosphoserine arg L-cystathionine bisphosphate guanosine catalytic subunit MoaE: HMPREF9701_RS30360 agmatine chorismate mutase: dihydropyrimidinase: decarboxylase: an N-terminal L- HMPREF9701_RS30930 HMPREF9701_RS04040 E. coli M branched-chain amino glutamate 5-kinase: diacetylchitobiose triacetylchitotriose HMPREF9701_RS040801-stearoyl-2- an N-formyl- HMPREF9701_RS14100 HMPREF9701_RS03100 [+ 8 isozymes] HMPREF9701_RS19990 [+ 3 isozymes] [+ 18 isozymes] HMPREF9701_RS30475 HMPREF9701_RS03240 HMPREF9701_RS30475 LPS agmatinase: HMPREF9701_RS10835 3-phosphooxypyruvate leu aminotransferase: inosine Arg spermidine biosynthesis I HMPREF9701_RS11205 HMPREF9701_RS14845 arginase: HMPREF9701_RS01645 HMPREF9701_RS12380 bifunctional (R)-3-amino-2- UTP and CTP dephosphorylation I isovaleryl-CoA AMP diphosphate a [SAMP] C- arginiyl-3-sulfo- a tRNA (2E,11Z)- Co 2+ Co 2+ HMPREF9701_RS02665 acid transaminase: HMPREF9701_RS14840 γ beta-N- acyl-carrier protein oleoyl-sn-glycerol L-methionyl- a tetrahydrofolate molybdopterin [DNA] 8-(methylthio)- RS23780 -L-glutamyl HMPREF9701_RS23255 methylpropanoate terminal glycine L-alanyl-[protein] acetaldehyde 4-guanidinobutanoate a folate (R)-lactate urate laurate 2+ 2+ polyamine histidinal HMPREF9701_RS07820 3-phosphoserine prephenate hydantoinase/oxoprolinase acetylhexosaminidase: metallophosphatase/ 3-phosphate [initiator tRNA met ] octadecenoyl-CoA 2-oxooctanoate Mg Mg 5-phosphate lys UTP aminopropyltransferase: putrescine aminotransferase: 3-phospho- L-ornithine family protein: HMPREF9701_RS03330 5'-nucleotidase: SAM L-serine gamma-glutamyl- prephenate dehydratase: S-adenosyl-L-methionine cycle I HMPREF9701_RS27590 histidinol dehydrogenase: ile HMPREF9701_RS14840 HMPREF9701_RS10255 N-acetyl-D- HMPREF9701_RS08690 β RS02880 phosphate reductase: HMPREF9701_RS14845 cys CTP synthase: pyrG ditrans,octacis-undecaprenyldiphospho- 3-benzyl-3,6-dihydroxy- a [DNA]-3'- a 5'-phospho- N-acetyl- -D-glucosamine- a dimer of (11Z)- (3E)-2-chloro-5- 3-[(4'-methylthio) a 5' triphospho- phosphoenol HMPREF9701_RS10835 + an L-arginyl- phosphoserine glucosamine guanine 5'-nucleotidase: 6-(hydroxymethyl) glutathione NAD an N-terminal L- [EntF L-seryl- 1,6-anhydro-N- ν an adenine in DNA a fatty aldehyde taurine RS06600 taurine 3-phospho- HMPREF9701_RS29205 3-ureidopropanoate N-acetyl-(N-acetylglucosaminyl) hydroxyl [DNA] Arg coenzyme A non-adjacent h hexadecenoyl-CoA oxohex-3-enedioate butyl]malate [mRNA] pyruvate S-methyl-5'- N 1 -(3-aminopropyl) phosphatase SerB: keto- HMPREF9701_RS08585 [tRNA ] glutamyl-[protein] carrier protein] SAM hypoxanthine muramoyl-L-alanyl-γ-D-isoglutaminyl- -diketopiperazine glutathione S-transferase: DNA ligase D: acetyl-β-D-muramate thymidines in DNA putrescine dAdoMet L-serine HMPREF9701_RS01560 CTP UMP arginyltransferase: holo-ACP synthase: beta-N- deoxyribodipyrimidine acyl-CoA dehydrogenase: DNA adenine methylase: 2-oxo-hepta-3-ene-1,7- aldehyde dehydrogenase 3-isopropylmalate RNA thioadenosine agmatine his L-glutamate-5- phenylpyruvate N-(β-D-asparaginyl)-L-lysyl-D-alanine HMPREF9701_RS21770 pyruvate kinase: phosphoserine L-glutamate-5- penicillin-binding protein 2: HMPREF9701_RS03980 HMPREF9701_RS03335 acetylhexosaminidase: photo-lyase: HMPREF9701_RS23335 HMPREF9701_RS00950 dioic acid hydratase: (NAD(+)): dehydrogenase: pyrophosphohydrolase: semialdehyde aspartate/tyrosine/ S-adenosyl-L-methionine cycle II guanine deaminase: xanthosine bifunctional an N-terminal HMPREF9701_RS30360 a holo-[EntF HMPREF9701_RS18170 spermidine synthase: phosphatase SerB: ser semialdehyde HMPREF9701_RS04650 3-benzyl-3,6 -bis(glutathione)[+ 8 isozymes] HMPREF9701_RS03330 HMPREF9701_RS04110 [+ 18 isozymes] [+ 2 isozymes] HMPREF9701_RS05125 HMPREF9701_RS30475 HMPREF9701_RS03240 HMPREF9701_RS11210 sulfite RS24475 sulfite RS02900 L-alanine biosynthesis I aromatic aminotransferase: methionine HMPREF9701_RS15540 metallophosphatase/ di-trans,octa-cis- a peptidoglycan dimer Arg HMPREF9701_RS13430 xanthine dehydrogenase: NMN AMP [DNA] L-arginiyl-L- a tRNA 3',5'-ADP L-seryl-carrier 1,6-anhydro-N- 6 HMPREF9701_RS01560 delta-1-pyrroline- adenosyltransferase: adenosine nucleotides - 6-(hydroxymethyl) GlcNAc a thymidine in DNA (2E,11Z)-hexadec- an N -methyladenine (3E)-5-chloro-2- 7-(methylthio)-2- a 5'-phospho- HMPREF9701_RS28670 β-alanine HMPREF9701_RS07000 guanine deaminase: CMP 5'-nucleotidase: undecaprenyl diphosphate (E. faecium, tetrapeptide) glutamyl-[protein] protein] acetyl-β-muramate a fatty acid pyruvate serine met HMPREF9701_RS10440 -diketopiperazine 2,11-dienoyl-CoA in DNA oxopent-3-enoate oxoheptanoate [mRNA] spermidine spermidine 3-methyl-2- aspartate/tyrosine/ 5-carboxylate methionine HMPREF9701_RS17720 degradation III HMPREF9701_RS08690 ser hydroxymethyltransferase: glyA HMPREF9701_RS07005 acetate acetate oxobutanoate (S)-1-pyrroline- aromatic aminotransferase: dehydrogenase: adenosyltransferase: bifunctional branched-chain amino [+ 2 isozymes] met SAH 5'-nucleotidase: 5-carboxylate HMPREF9701_RS09945 HMPREF9701_RS19300 HMPREF9701_RS10440 metallophosphatase/ a methylated a dimer of adjacent RS19225 acid transaminase: serine O-acetyltransferase: methionine synthase: HMPREF9701_RS08585 6 37 (7Z)- 5-hydroxyindole 3-[(7'-methylthio) (3S)- xanthine AMP 5'-nucleotidase: N -dimethylallyladenosine a sulfurated glutathione monochlorobimane an L-arginyl- an N-terminal L- ν glutathione RX oleoyl-CoA a uridine in tRNA pyrazinamide RS02910 pyrroline-5- 5'-methylthioadenosine/ nucleobase 2-oxoglutarate Arg VibB coenzyme A 2'-deoxycytidine and h hexadecenoyl-CoA acetaldehyde heptyl]malate citramalyl-CoA a cation a cation HMPREF9701_RS07820 HMPREF9701_RS15625 gly HMPREF9701_RS08365 uridine [sulfur carrier] [tRNA ] aspartyl-[protein] carboxylate reductase: glu adenosylhomocysteine AMP nucleosidase: HMPREF9701_RS08690 in tRNA within DNA glutathione S-transferase: thymidine in DNA glutathione S-transferase: acetate acetate val phe [+ 2 isozymes] xanthine dehydrogenase: DNA oxidative arginyltransferase: holo-ACP synthase: deoxyribodipyrimidine acyl-CoA dehydrogenase: acyl-CoA dehydrogenase: tRNA dihydrouridine aldehyde dehydrogenase 3-isopropylmalate mesaconyl-C4 amidase: serine acetyltransferase: HMPREF9701_RS12925 nucleosidase: C1 Compound Utilization and Assimilation HMPREF9701_RS24525 5'-nucleotidase: HMPREF9701_RS03980 HMPREF9701_RS03980 RS31405 methionine synthase: HMPREF9701_RS07000 demethylase AlkB: HMPREF9701_RS30360 HMPREF9701_RS03335 photo-lyase: HMPREF9701_RS20295 HMPREF9701_RS20295 synthase DusB: (NAD(+)): dehydrogenase: CoA hydratase: HMPREF9701_RS20375 HMPREF9701_RS27555 HMPREF9701_RS18040 HMPREF9701_RS08585 2-methylsulfanyl-N 6 - [+ 8 isozymes] an N-terminal [+ 8 isozymes] HMPREF9701_RS08365 HMPREF9701_RS07005 adenine an unsulfurated HMPREF9701_RS17450 a holo-[VibB aryl- HMPREF9701_RS04110 [+ 18 isozymes] [+ 18 isozymes] HMPREF9701_RS04170 HMPREF9701_RS30475 HMPREF9701_RS03240 HMPREF9701_RS20300 [+ 3 isozymes] a cation a cation L-homocysteine SAM met 5'-deoxyadenosine dimethylallyladenosine 37 a nucleobase (glutathion- L-arginiyl-L- a tRNA Arg 3',5'-ADP adjacent 2'-deoxycytidine- a glutathione- O-acetyl-L-serine pro [+ 2 isozymes] formaldehyde oxidation cytidine [sulfur carrier] succinate formaldehyde carrier protein] HX (2E,7Z)- (2E,9Z)- a 5,6-dihydrouridine 5-hydroxyindole 10-(methylthio)- 3-methylfumaryl- pyrazine-2- hydrogen sulfide S-ribosyl-L- L-selenocysteine biosynthesis I (bacteria) formaldehyde oxidation in tRNA within DNA S-yl)-bimane aspartyl-[protein] thymidine in DNA S-conjugate RS27355 L-ornithine degradation L-homocysteine VII (THF pathway) formaldehyde oxidation urate hexadecenoyl-CoA octadecenoyl-CoA in tRNA acetate 2-oxodecanoate CoA carboxylate homocysteine II (glutathione-dependent) I (L-proline biosynthesis) IV (thiol-independent) ala ATP cysteine synthase A: ser a tRNA sec selenide formaldehyde APS formaldehyde formaldehyde a [glycine-cleavage a dimer of non-adjacent a peptide with a [protein]- an organic a dimer of non- RNase G degradation uridine 746 3-[(3'-methylthio) (2R,3S)-3- HMPREF9701_RS04760 N 3 -methylcytosine 2-oxoglutarate glutathione fenclorim palmitoleoyl-CoA palmitoyl-CoA oxaloacetate sulfate adenylyltransferase: L-ornithine adenosylhomocysteinase: selenide, water aldehyde dehydrogenase SAM complex H protein] a sulfurated [sulfur carrier] thymidine and 2'- hν an N-terminal L-cysteine hydroperoxide adjacent pyrimidine hν substrate mRNA in 23S rRNA propyl]malate isopropylmalate alanine racemase: [+ 3 isozymes] Fatty Acid and Lipid Degradation fatty acid β-oxidation I adenylyl-sulfate kinase: HMPREF9701_RS06455 ornithine cyclodeaminase: HMPREF9701_RS07060 serine--tRNA ligase: (NAD(+)): N 6 -octanoyl-L-lysine deoxycytidine in DNA DNA oxidative Xaa-L-proline peroxiredoxin: nucleosides in DNA glutathione S-transferase: RS02955 HMPREF9701_RS07850 dikinase SelD: a 5,10- lipoyl synthase: deoxyribodipyrimidine deoxyribodipyrimidine acyl-CoA dehydrogenase: 23S rRNA acyl-CoA dehydrogenase: 3-isopropylmalate 3-isopropylmalate phosphoenolpyruvate HMPREF9701_RS25295 HMPREF9701_RS10040 HMPREF9701_RS19495 S-(hydroxymethyl) demethylase AlkB: leucyl aminopeptidase: HMPREF9701_RS03160 ribonuclease G: HMPREF9701_RS06460 SAH HMPREF9701_RS26880 methylenetetrahydrofolate HMPREF9701_RS30475 photo-lyase: photo-lyase: HMPREF9701_RS03980 HMPREF9701_RS20295 pseudouridine synthase: HMPREF9701_RS23335 dehydrogenase: dehydrogenase: carboxykinase (GTP): a (3Z)-alk-3- HMPREF9701_RS07295 HMPREF9701_RS16425 HMPREF9701_RS27120 ornithine cyclodeaminase: glutathione formate a [glycine-cleavage HMPREF9701_RS17450 a peptide with [+ 3 isozymes] [+ 8 isozymes] HMPREF9701_RS21255 HMPREF9701_RS03240 HMPREF9701_RS03240 HMPREF9701_RS30025 D-ala cys PAPS APS an L-seryl- bifunctional enoyl-CoA an unsulfurated HMPREF9701_RS04110 a proteinogenic an intra- HMPREF9701_RS04110 4-(glutathion- [+ 18 isozymes] [+ 18 isozymes] HMPREF9701_RS23260 S-(hydroxymethyl) 5'-deoxyadenosine met complex H protein] a 2'-deoxycytidine an N-terminal a pyrimidine 746 sec selenophosphate succinate formaldehyde cytosine an alcohol (2E,9Z)- a pseudouridine trans-hexadec- 6-(methylthio)- 4-methyl-2- phosphoenol [tRNA ] methylenetetrahydrofolate [sulfur carrier] 6 a thymidine in DNA amino acid protein disulfide S-yl)-fenclorim pro glutathione ∆ 3 ∆ 2 N -lipoyl-L-lysine in DNA L-proline nucleoside in DNA an mRNA fragment dehydrogenase/ -cis- -trans-enoyl- hexadecenoyl-CoA in 23S rRNA 2-enoyl-CoA 2-oxohexanoate oxopentanoate pyruvate dehydrogenase/class III RS28520 methenyltetrahydrofolate CoA isomerase: L-seryl-tRNA(Sec) alcohol dehydrogenase: cyclohydrolase FolD: HMPREF9701_RS26425 selenium transferase: HMPREF9701_RS20000 a dimer of non-adjacent (R)-1- (5Z,8Z,11Z,14Z,17Z) an all-trans a dimer of adjacent HMPREF9701_RS28555 a sulfurated adenosylcobyrate coenzyme A a carboxylic ester a RNA-DNA hybrid N-acetyl- 4-hydroxybenzoate reduced riboflavin octanoyl-CoA a quinone malonyl-CoA HMPREF9701_RS26915 SAM dethiobiotin 2'-deoxycytidine and hν aminopropan-2-ol -icosapentaenoate pyrimidine hν [sulfur carrier] -retinyl ester L-citrulline a 5,10- S-formylglutathione thymidine in DNA adenosylcobinamide- fatty acid--CoA ligase: carboxylesterase: nucleosides in DNA carboxylesterase: ribonuclease H: biotin synthase: deoxyribodipyrimidine deoxyribodipyrimidine acetylornithine 4-hydroxybenzoate FMN reductase: acyl-CoA dehydrogenase: malonyl-CoA an L- methenyltetrahydrofolate a 2,3,4-saturated phosphate synthase: HMPREF9701_RS21695 HMPREF9701_RS30100 HMPREF9701_RS30100 HMPREF9701_RS14795 quinone oxidoreductase: coenzyme A fatty acid--CoA ligase: a (2E)-2- HMPREF9701_RS17390 photo-lyase: photo-lyase: deacetylase: 3-monooxygenase: HMPREF9701_RS19890 HMPREF9701_RS23335 decarboxylase: RS11430 selenocysteinyl- S-formylglutathione fatty acid HMPREF9701_RS11930 HMPREF9701_RS10285 bifunctional HMPREF9701_RS21695 enoyl-CoA enoyl-CoA hydratase:3-hydroxybutyryl- a 2,3,4- an unsulfurated HMPREF9701_RS04110 [+ 10 isozymes] [+ 2 isozymes] HMPREF9701_RS04110 [+ 2 isozymes] [+ 2 isozymes] HMPREF9701_RS08340 HMPREF9701_RS21865 [+ 5 isozymes] [+ 18 isozymes] HMPREF9701_RS01150 [tRNA sec ] hydrolase: met 5'-deoxyadenosine biotin a 2'-deoxycytidine (5Z,8Z,11Z,14Z,17Z) two adjacent pyrimidine a nucleoside 5'- methylenetetrahydrofolate HMPREF9701_RS26425CoA epimerase: saturated (3R)-3- [sulfur carrier] a thymidine in DNA adenosylcobinamide a fatty acid all-trans-retinol a carboxylate an alcohol DNA acetate L-citrulline (2E)-oct-2- HMPREF9701_RS19995 [+ 10 isozymes] acyl-CoA dehydrogenase: -icosapentaenoyl-CoA monophosphate protocatechuate riboflavin a semiquinone acetyl-CoA dehydrogenase/ hydroxyacyl-CoA in DNA nucleosides in DNA enoyl-CoA HMPREF9701_RS20295 HMPREF9701_RS26425 methenyltetrahydrofolate formate [+ 18 isozymes] a 2,3,4- cyclohydrolase FolD: a 2,3,4-saturated RS24860 saturated (3S)-3- lipid II (meso (S)-5-amino-3- 1-chloro-2,4- a dimer of adjacent 2'- 5-dehydro-2- imidazole a peptide with a uridine 65 D-glucurono- HMPREF9701_RS28555 1-deoxy-D-xylulose a thiocarboxy- glutathione ν an L-arginyl- FMNH NADP + fatty acyl CoA acetyl-CoA h 2 phenylglyoxylate 1-octanal formate oxidation to CO hydroxyacyl-CoA 2-iminoacetate diaminopimelate oxohexanoate dinitrobenzene deoxycytidines in DNA Arg a protein deoxy-D-gluconate acetaldehyde an N-terminal in tRNA 6,3-lactone an N 10 - 2 3-hydroxyacyl-CoA 5-phosphate [ThiS-Protein] [tRNA ] containing) 3-keto-5-aminohexanoate glutathione S-transferase: deoxyribodipyrimidine flavin reductase: 5-dehydro-2- aldehyde dehydrogenase L-alanine tRNA pseudouridine(65) benzoylformate aldehyde dehydrogenase aldehyde dehydrogenase formyltetrahydrofolate dehydrogenase: thiazole synthase: penicillin-binding protein 2: arginyltransferase: aminopeptidase N: cleavage protein: HMPREF9701_RS03980 photo-lyase: HMPREF9701_RS28115 deoxygluconokinase: (NAD(+)): synthase: decarboxylase: (NAD(+)): (NAD(+)): formate HMPREF9701_RS26425 HMPREF9701_RS26320 HMPREF9701_RS04650 HMPREF9701_RS30360 HMPREF9701_RS25310 formyltetrahydrofolate 2-[(2R,5Z)-2-carboxy- lipid II (meso di-trans,octa-cis HMPREF9701_RS21280 [+ 8 isozymes] HMPREF9701_RS04110 [+ 4 isozymes] HMPREF9701_RS12755 HMPREF9701_RS30475 HMPREF9701_RS23050 HMPREF9701_RS04255 HMPREF9701_RS30475 HMPREF9701_RS30475 oxidoreductase alpha a ThiS sulfur- an N-terminal Arg deformylase: (S)-3- 2,4-dinitrophenyl- two adjacent 2'- a tRNA + RS01195 a 2,3,4-saturated a 2,3,4-saturated 4-methylthiazol-5(2H)- diaminopimelate -undecaprenyl acetoacetate H NADPH FMN 5-dehydro-2-deoxy-D- a peptide ala 65 (molybdopterin) subunit: carrier protein aminobutanoyl-CoA S-glutathione deoxycytidines in DNA arginyl-[protein] a pseudouridine HMPREF9701_RS25070 fatty acyl CoA 3-oxoacyl-CoA ylidene]ethyl phosphate containing) diphosphate gluconate 6-phosphate 4-imidazoleacetate benzaldehyde D-glucarate octanoate HMPREF9701_RS13300 in tRNA CO formate 2 5-amino-4- an intra- methyl (indol- (3Z)-hex- an adenosine 34 acetyl-CoA C- indolylmethylisothiocyanate glutathione 2,3,6-trichlorohydroquinone glutathione glutathione methylmercury glutathione glutathione orotidine 5'- L-arabinitol PRPP uroporphyrinogen-I palmitaldehyde acetaldehyde Arg2 phytenal RS12095 acyltransferase: imidazolecarboxyamide protein disulfide 3-yl)acetate 3-en-1-ol phosphate in [tRNA ] glutathione S-transferase: glutathione S-transferase: adenine glutathione S-transferase: glutaredoxin 3: carboxylesterase: glutathione S-transferase: NAD(P)-dependent HMPREF9701_RS20325 orotate uroporphyrinogen aldehyde dehydrogenase aldehyde dehydrogenase tRNA adenosine(34) aldehyde dehydrogenase acetyl-CoA HMPREF9701_RS03980 HMPREF9701_RS03980 phosphoribosyltransferase: HMPREF9701_RS03980 HMPREF9701_RS12395 HMPREF9701_RS30100 HMPREF9701_RS03980 alcohol dehydrogenase: [+ 8 isozymes] two reduced phosphoribosyltransferase: decarboxylase: (NAD(+)): (NAD(+)): deaminase TadA: (NAD(+)): Inorganic Nutrient Metabolism [+ 8 isozymes] [+ 8 isozymes] HMPREF9701_RS29475 [+ 8 isozymes] [+ 2 isozymes] [+ 8 isozymes] HMPREF9701_RS07665 HMPREF9701_RS22560 HMPREF9701_RS07550 HMPREF9701_RS30475 HMPREF9701_RS30475 HMPREF9701_RS13320 HMPREF9701_RS30475 indol-3-ylmethylisothiocyanate- 2,6-dichloro-3-(glutathion- methylmercury- cysteine residues GSSG 3-(glutathion-S AICAR MeOH (indol-3-yl)acetate orotate PRPP L-arabinopyranose an inosine 34 glutathione S-yl)-hydroquinone S-glutatione in a protein -yl)-hexan-1-ol coproporphyrinogen I palmitate acetate phytenate selenate reduction Arg2 RS22595 nitrate reduction V (assimilatory) urea cycle in [tRNA ] sulfate reduction selenate III (assimilatory) nitrate an N 1 -methyladenine 2-bromo-3-(4- an N 3 -methyladenine an N-acetyl-β- β-D-fructofuranose an organic a farnesylated sulfate adenylyltransferase: arg 2-oxoglutarate glutathione a ribonucleic acid [DNA] FMNH NAD + methylsalicylate salicylaldehyde benzaldehyde in DNA nitrophenyl)propanoate in DNA D-hexosaminide 1-phosphate 2 a protein hydroperoxide protein that HMPREF9701_RS06455 arginase: sulfate beta-N- lys RS01515 lys nitrate reductase DNA oxidative glutathione S-transferase: ribonuclease T(1): DNA-3-methyladenine exodeoxyribonuclease I: fructose-bisphosphate flavin reductase: carboxylesterase: aldehyde dehydrogenase aldehyde dehydrogenase peroxiredoxin: ends with a HMPREF9701_RS06460 HMPREF9701_RS23255 sulfate adenylyltransferase: acetylhexosaminidase: endopeptidase La: adenosine 5'- subunit beta: demethylase AlkB: HMPREF9701_RS03980 HMPREF9701_RS29360 glycosylase I: HMPREF9701_RS27010 aldolase class II: HMPREF9701_RS28115 HMPREF9701_RS30100 (NAD(+)): (NAD(+)): HMPREF9701_RS03160 CaaX sequence argininosuccinate lyase: HMPREF9701_RS06455 a 2'- HMPREF9701_RS03330 HMPREF9701_RS00245 phosphoselenate HMPREF9701_RS25010 HMPREF9701_RS17450 [+ 8 isozymes] a ribonucleoside a 3' phosphooligo- HMPREF9701_RS04150 HMPREF9701_RS18145 [+ 4 isozymes] [+ 2 isozymes] HMPREF9701_RS30475 HMPREF9701_RS30475 HMPREF9701_RS12065 HMPREF9701_RS06460 2-(glutathion-S-yl)-3-(4- an apurinic site deoxyribonucleoside [DNA] an N-acetyl-β- [+ 3 isozymes] a [protein] C- 3'-phosphate ribonucleotide RNA + a peptide a peptide lys RS19690 lys ammonium succinate formaldehyde an adenine in DNA bromide 3-methyladenine an alcohol D-glyceraldehyde DHAP H NADH FMN MeOH salicylate a peptide terminal S- nitrite APS nitrophenyl)propanoate within DNA 5'-monophosphate D-hexosamine salicylate benzoate an alcohol farnesyl-L-cysteine nitrite reductase L-arginino- carbamoyl-phosphate phosphoadenylyl- L-ornithine selenite (NAD(P)H) small subunit: succinate synthase: carB sulfate reductase: RS01340 an N 1 -ethyladenine 2,3,5,6- RNase R degradation (indol-3- S-(2-hydroxyacyl) (-)-methyl all-trans- a supercoiled an organic HMPREF9701_RS19325 HMPREF9701_RS30725 HMPREF9701_RS06450 2-oxoglutarate glutathione methyl red coenzyme A precorrin-2 Co 2+ hexanoyl-CoA oxaloacetate in DNA tetrachlorohydroquinone substrate RNA asp fumarate yl)pyruvate glutathione jasmonate retinyl palmitate duplex DNA molecule carbamoyl DNA oxidative glutathione S-transferase: FMN-dependent indolepyruvate ferredoxin hydroxyacylglutathione carboxylesterase: carboxylesterase: sirohydrochlorin ammonium sulfite ribonuclease R: L-aspartate oxidase: acyl-CoA dehydrogenase: replicative DNA helicase: phosphate demethylase AlkB: HMPREF9701_RS03980 NADH-azoreductase: oxidoreductase: hydrolase: HMPREF9701_RS30100 HMPREF9701_RS30100 cobaltochelatase: 2-methylcitrate synthase: cytochrome P450: ornithine HMPREF9701_RS30820 HMPREF9701_RS10055 HMPREF9701_RS23335 HMPREF9701_RS03815 assimilatory sulfite HMPREF9701_RS17450 a nucleoside 5'- HMPREF9701_RS05910 HMPREF9701_RS14145 HMPREF9701_RS30550 HMPREF9701_RS16410 HMPREF9701_RS06785 HMPREF9701_RS23285 selenodiglutathione argininosuccinate synthase: carbamoyltransferase: [+ 8 isozymes] a diribonucleotide [+ 2 isozymes] [+ 2 isozymes] [+ 18 isozymes] [+ 4 isozymes] glutamine synthetase: NADP-specific glutamate reductase (NADPH): 2,3,5-trichloro-6-(glutathion- monophosphate N,N-dimethyl-1,4- succinate 2-iminosuccinate S-2-(indol-3 a 2-hydroxy RS08530 HMPREF9701_RS13475 HMPREF9701_RS09900 succinate acetaldehyde an adenine in DNA anthranilate glutathione MeOH (-)-jasmonate palmitate a retinol cobalt-precorrin-2 trans-hex-2- a single (2S,3S)-2- HMPREF9701_RS31105 dehydrogenase: HMPREF9701_RS06440 S-yl)-hydroquinone phenylenediamine yl)acetyl-CoA carboxylate an alcohol HMPREF9701_RS02755 L-citrulline enoyl-CoA stranded DNA methylcitrate hydrogen sulfide gln glutathioselenol an N 3 -methylcytosine an (R)-2- (2S)- a dimer of adjacent CDP-4-dehydro-3,6- an N-hydroxy- 2-keto-D- a peptidoglycan a lipid II + ν 2+ L-canavanine glu 2-oxoglutarate NADH menadione H methylsuccinyl- acetyl-CoA h protoporphyrin IX Mg formate dideoxy-D-glucose xylitol D-mannitol RS29195 in DNA halocarboxylate thymidines in DNA arylamine gluconate sulfoacetaldehyde degradation I DNA oxidative penicillin-binding protein 2: HAD family hydrolase: NADH-quinone CoA deoxyribodipyrimidine magnesium formate dehydrogenase- CDP-4-dehydro-6- arginase: NAD(P)-dependent NAD(P)-dependent 3-oxoadipyl-CoA thiolase: N-hydroxyarylamine 2,5-didehydrogluconate demethylase AlkB: HMPREF9701_RS04650 HMPREF9701_RS15330 oxidoreductase subunit B: photo-lyase: chelatase subunit I: N subunit alpha: deoxyglucose reductase: HMPREF9701_RS23255 O-acetyltransferase: alcohol dehydrogenase: reductase DkgB: alcohol dehydrogenase: phosphonoacetate degradation di-trans,octa-cis HMPREF9701_RS10645 sulfoacetaldehyde HMPREF9701_RS17450 an (S)-2- HMPREF9701_RS02940 4-methyl-3- HMPREF9701_RS04110 HMPREF9701_RS08790 HMPREF9701_RS26935 HMPREF9701_RS09835 HMPREF9701_RS21445 HMPREF9701_RS07550 HMPREF9701_RS18095 HMPREF9701_RS07550 -undecaprenyl a peptidoglycan a halide anion two adjacent Mg- an electron- CDP-4-dehydro- urea L-canaline hydrogen selenide sulfate activation succinate formaldehyde a cytosine in DNA hydroxycarboxylate menadiol NAD + oxoadipyl-CoA CO aldehydo- diphosphate thymidines in DNA protoporphyrin transfer quinol 2 an N- D-xylopyranose 2,5-didehydro- for sulfonation phosphonoacetate 6-deoxy-D-glucose D-mannose sulfoacetaldehyde taurine degradation IV acetoxyarylamine D-gluconate RS17750 phosphonoacetate acetyltransferase: sulfate hydrolase: sulfate adenylyltransferase: HMPREF9701_RS19390 taurine β GDP-α-D- HMPREF9701_RS08320 5,10-methylene- 3-methyl-2- RNase III mRNA an (S)-2- an L-1- O-ureido-L- (R)-N-formyl- - chitin D-galactopyranose a peptide with a HMPREF9701_RS06455 taurine dioxygenase: CO asp H O diphosphate a phenyl acetate mannose prop-2-ynal acetate tetrahydromethanopterin oxobutanoate processing substrate halocarboxylate phosphatidylethanolamine homoserine hydroxy-L-kynurenine 2 6-phosphate leader sequence D-serine D-serine HMPREF9701_RS06460 HMPREF9701_RS19310 3-methyl-2-oxobutanoate ribonuclease 3: HAD family hydrolase: (2Fe-2S)-binding protein: arylformamidase: beta-N- arylesterase: GDP-mannose acetyl phosphate sulfite argininosuccinate synthase: inorganic diphosphatase: ribose 5-phosphate aldehyde dehydrogenase gly RS17225 gly APS hydroxymethyltransferase: HMPREF9701_RS09560 acetylhexosaminidase: HMPREF9701_RS28810 [+ 3 isozymes] HMPREF9701_RS03355 HMPREF9701_RS15330 HMPREF9701_RS13475 HMPREF9701_RS09975 HMPREF9701_RS30460 isomerase B: 4,6-dehydratase: (NAD(+)): D-ala D-ala 2-aminoacetaldehyde HMPREF9701_RS12360 RNase III processing an (S)-2- a reduced a 2-acyl-1-lyso- β HMPREF9701_RS03330 + (R)- -hydroxy- HMPREF9701_RS05865 HMPREF9701_RS10415 HMPREF9701_RS30475 phosphate an mRNA fragment a halide anion H ferredoxin [iron- CO a fatty acid canavaninosuccinate formate phosphate H + N-acetyl-D- acetate a phenol adenylyl-sulfate kinase: product mRNA hydroxycarboxylate 2 phosphatidylethanolamine L-kynurenine chitin GDP-4-dehydro- a leader sequence a peptide acetyltransferase: THMPT 2-dehydropantoate D-tagatofuranose HMPREF9701_RS25295 sulfur] cluster glucosamine α-D-rhamnose propynoate HMPREF9701_RS19395 6-phosphate RS13895 PAPS [+ 2 isozymes] an L-1- lipid A 1-(2-aminoethyl 7,8- 7,8-dihydrofolate an (R)-2- acetyl-CoA NADPH H + a single a ribonucleoside a uracil in DNA canavaninosuccinate formyl-CoA succinate H O acetyl-CoA chitin glycerol 5-methylcytosine 5-fluorocytosine orotidine 5'- phosphatidylethanolamine diphosphate) (E. coli) dihydromonapterin monoglutamate stranded DNA triphosphate halocarboxylate 2 phosphate allantoinase PuuE: dihydroneopterin aldolase: dihydrofolate reductase: DNA primase: HAD family hydrolase: uracil-DNA glycosylase: argininosuccinate lyase: CoA transferase: acetyl-CoA hydrolase: NAD(P)-dependent orotidine 5'-phosphate Carboxylate Degradation HMPREF9701_RS17880 cytosine deaminase: cytosine deaminase: RS14875 HMPREF9701_RS24355 HMPREF9701_RS30930 HMPREF9701_RS31315 HMPREF9701_RS15330 HMPREF9701_RS15010 HMPREF9701_RS12065 HMPREF9701_RS09765 HMPREF9701_RS29865 alcohol dehydrogenase: decarboxylase: lipid A 1,4'-bis(2-aminoethyl 6-(hydroxymethyl) tetrahydropteroyl an (R)-2- an apyrimidinic HMPREF9701_RS31065 HMPREF9701_RS31065 a 1,2-diacyl-sn-glycerol glycolaldehyde NADP + ssDNA/pppN(pN) a halide anion uracil fumarate L-canavanine succinyl-CoA formate acetate acetate chitosan HMPREF9701_RS07550 HMPREF9701_RS14065 -7,8-dihydropterin mono-L-glutamate hydroxyacid site in DNA glycolate and diphosphate) (E. coli) hybrid thymine 5-fluorouracil pyruvate fermentation to acetate IV citrate degradation n -1 L-glyceraldehyde UMP glyoxylate degradation I oxalate degradation II superpathway of acetate utilization and formation an acetyl-holo RS20980 glycolate pyruvate oxalate acetate [citrate lyase acyl- citrate glycolate dehydrogenase: acetate--CoA ligase: carrier protein] citrate-ACP transferase: HMPREF9701_RS07875 acetate/propionate HMPREF9701_RS01090 a citryl-holoHMPREF9701_RS20070 glyoxylate oxalyl-CoA family kinase: [citrate lyase acyl- HMPREF9701_RS14915 carrier protein] RS07720 glyoxylate carboligase: acetyl-CoA formate citrate lyase subunit acetyl phosphate HMPREF9701_RS17845 acetyl-CoA beta/citryl-CoA lyase: phosphate HMPREF9701_RS20070 tartronate acetyltransferase: formyl-CoA citryl-CoA lyase: semialdehyde HMPREF9701_RS19395 2-hydroxy-3- HMPREF9701_RS15160 [+ 2 isozymes] CoA transferase: phosphate RS13675 oxopropionate reductase: HMPREF9701_RS09765 acetyltransferase: oxaloacetate HMPREF9701_RS17835 acetyl phosphate HMPREF9701_RS19395 D-glycerate formate [+ 2 isozymes] acetate/propionate family kinase: D-gluconate degradation RS29685 HMPREF9701_RS14915

2-phospho- acetate D-gluconate D-glycerate gluconokinase: HMPREF9701_RS17320 D-gluconate RS26740 a branched- 6-phosphate chain glycine betaine an aliphatic amino acid L-proline betaine (2-aminoethyl) sulfonate phosphate molybdate a branched- a branched- sulfate a sulfonate phosphonate a polar a polar a polar a polar a polar phosphonate phosphonate a carbohydrate a carbohydrate a lyso- 3,5- chain chain D-methionine D-methionine thiosulfate an inorganic an inorganic cis-vaccenoyl-CoA cis-vaccenoyl-CoA cis-vaccenoyl-CoA cis-vaccenoyl-CoA cis-vaccenoyl-CoA cis-vaccenoyl-CoA cis-vaccenoyl-CoA cis-vaccenoyl-CoA cis-vaccenoyl-CoA cis-vaccenoyl-CoA cis-vaccenoyl-CoA phosphonate a C4- D-fructose L-ascorbate spermidine a polyamine amino acid a lipopolysaccharide (S)-lactate (S)-lactate chromate chromate chromate molybdate ammonium ammonium sulfate a tricarboxylate a tricarboxylate an antibiotic a macrolide a nucleotide benzoate benzoate a monosaccharide phospholipid D-glucopyranose dimethoxytoluene an aromatic amino acid amino acid amino acid amino acid a lipopolysaccharide a lipopolysaccharide a carbohydrate a carbohydrate D-gluconate sulfate anion anion a 2,3,4-saturated fatty acyl CoA a 2,3,4-saturated fatty acyl CoA a 2,3,4-saturated fatty acyl CoA a 2,3,4-saturated fatty acyl CoA a 2,3,4-saturated fatty acyl CoA a 2,3,4-saturated fatty acyl CoA a 2,3,4-saturated fatty acyl CoA a 2,3,4-saturated fatty acyl CoA a 2,3,4-saturated fatty acyl CoA a 2,3,4-saturated fatty acyl CoA a 2,3,4-saturated fatty acyl CoA an alkylphosphonate dicarboxylate 1-phosphate 6-phosphate phosphate a lipopolysaccharide a lipopolysaccharide a lipopolysaccharide predicted amino acid amino acid sulfate sulfate predicted carboxylate predicted ABC ABC predicted ABC ABC predicted predicted predicted predicted predicted ABC predicted ABC predicted ABC predicted ABC predicted ABC transporter transporter transporter of transporter ABC ABC ABC ABC RS10810 RS13900 RS10785 RS17760 RS23275 RS18560 RS28580 RS14135 RS13650 RS23070 RS10810 RS26415 RS07855 RS26415 RS14305 RS28510 RS08375 RS05710 RS10765 RS08890 RS08900 transporter of transporter of RS24025 RS24540 efflux transporter of RS29460 RS25725 RS25720 RS03615 RS26545 RS03645 transporter of transporter of RS10490 RS28750 RS28755 RS05395 RS15405 of a RS16780 RS11830 RS10360 RS12580 RS05115 RS16095 RS07900 RS08215 RS06390 RS08630 RS19400 RS28840 RS14020 RS23315 RS11665 RS21695 RS20360 RS18090 RS24765 RS28085 RS29605 RS04965 RS24265 RS31290 RS25240 RS17285 RS11630 RS10815 RS08350 of L-proline RS01065 RS07320 RS25940 RS03200 RS32180 RS09745 RS12475 RS07200 RS16740 RS11890 RS17950 RS30770 RS17125 RS29180 (2-aminoethyl) of an transporter transporter transporter transporter phosphonate phosphonate a lipopolysaccharide a carbohydrate a carbohydrate branched- betaine/ phosphonate aliphatic of molybdate of sulfate of a sulfonate of phosphate chain glycine a lyso- 3,5- sulfonate a branched- a branched- thiosulfate an inorganic an inorganic cis-vaccenate cis-vaccenate cis-vaccenate cis-vaccenate cis-vaccenate cis-vaccenate cis-vaccenate cis-vaccenate cis-vaccenate cis-vaccenate cis-vaccenate phosphonate a C4- spermidine a polyamine a monosaccharide D-glucopyranose a polar a polar a polar a polar a polar a lipopolysaccharide a lipopolysaccharide (S)-lactate (S)-lactate a carbohydrate a carbohydrate chromate chromate chromate molybdate amino acid D-gluconate ammonium ammonium sulfate a tricarboxylate a tricarboxylate an antibiotic betaine D-fructose L-ascorbate a macrolide a nucleotide benzoate benzoate phospholipid dimethoxytoluene an aromatic a lipopolysaccharide a lipopolysaccharide a lipopolysaccharide chain chain D-methionine D-methionine sulfate sulfate sulfate anion anion a 2,3,4-saturated fatty acid a 2,3,4-saturated fatty acid a 2,3,4-saturated fatty acid a 2,3,4-saturated fatty acid a 2,3,4-saturated fatty acid a 2,3,4-saturated fatty acid a 2,3,4-saturated fatty acid a 2,3,4-saturated fatty acid a 2,3,4-saturated fatty acid a 2,3,4-saturated fatty acid a 2,3,4-saturated fatty acid an alkylphosphonate dicarboxylate (2-aminoethyl) amino acid amino acid amino acid amino acid amino acid phosphonate phosphonate a carbohydrate a carbohydrate phosphate carboxylate a lipopolysaccharide molybdate amino acid amino acid sulfate a sulfonate phosphate an aliphatic phosphonate a branched- sulfonate glycine betaine chain L-proline betaine amino acid This diagram was automatically generated by SRI International Pathway Tools version 25.0, authors S. Paley and P.D. Karp.