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SCIENTIFIC ANOMALY AND BIOLOGICAL EFFECTS OF LOW-DOSE CHEMICALS: ELUCIDATING NORMATIVE ETHICS AND SCIENTIFIC DISCOVERY A Dissertation Submitted to the Graduate School of the University of Notre Dame in Partial Fulfillment of the Requirements for the Degree of Doctor of Philosophy by Kevin Christopher Elliott, B.S., M.A. _________________________________ Kristin S. Shrader-Frechette, Director Graduate Program in History and Philosophy of Science Notre Dame, Indiana April 2004 © Copyright by Kevin C. Elliott 2004 All rights reserved SCIENTIFIC ANOMALY AND BIOLOGICAL EFFECTS OF LOW-DOSE CHEMICALS: ELUCIDATING NORMATIVE ETHICS AND SCIENTIFIC DISCOVERY Abstract by Kevin Christopher Elliott The notion of “anomaly” has persisted for over 2,000 years, but its precise meaning and significance remains unclear. This dissertation analyzes the importance of scientific anomaly both for the philosophy of science and for ethical decision-making that draws on scientific information. In the philosophy of science, it develops a novel account of anomaly. It first provides a conceptual framework for describing anomalies and critically evaluates previous descriptions by Karl Popper, Thomas Kuhn, Imre Lakatos, Larry Laudan, and Lindley Darden. Using the anomalous contemporary biological phenomenon known as “chemical hormesis” (i.e., beneficial effects from low doses of toxins) as a case study, the dissertation argues for a novel account that emphasizes three features of anomaly. Namely, researchers “characterize” anomalies in multiple ways, scientists use multiple strategies to “confirm” them, and anomalies interact with novel hypotheses in an ongoing, dialectical fashion. The dissertation argues that this account is significant because it facilitates increased understanding of scientific discovery and of the role that value judgments play in science. The ethical component of the dissertation analyzes the ethical ramifications both of the hormesis case in particular and of policy-relevant anomalies in general. Concerning the hormesis case, it argues that current evidence for the anomaly does not provide adequate reason to alter regulatory policy. In the process, the dissertation contributes to metaethics by developing a novel formulation of the naturalistic fallacy and by clarifying its relation to the is/ought distinction. Regarding scientific anomaly in general, the dissertation argues that researchers and policymakers have an ethical responsibility to take reasonable steps to identify, reveal, and provide representative information about all major, plausible characterizations of scientific anomalies to the public or its representatives. This study suggests three rules of thumb (namely, analysis of anomalies via analytic-deliberative processes, elimination and disclosure of conflicts of interest, and research-ethics education on scientists’ social responsibilities) to help researchers meet their ethical responsibilities with respect to anomalies. The dissertation as a whole illustrates how the philosophy of science can contribute not only to greater understanding of scientific reasoning but also to ethical insights for using scientific knowledge. For Janet, whose love never fails ii TABLE OF CONTENTS ACKNOWLEDGMENTS ...................................................................................................v CHAPTER 1: INTRODUCTION........................................................................................1 1.1 Introduction.................................................................................................................1 1.2 Motivation for the Dissertation...................................................................................3 1.3 Chapter Outline...........................................................................................................7 1.4 Conclusion ................................................................................................................11 CHAPTER 2: FIVE ACCOUNTS OF SCIENTIFIC ANOMALY...................................13 2.1 Introduction...............................................................................................................13 2.2 Terminology and Methodology ................................................................................14 2.3 Description of the Previous Accounts ......................................................................32 2.4 Evaluation of the Previous Accounts........................................................................50 2.5 Conclusion ................................................................................................................60 CHAPTER 3: CHEMICAL HORMESIS: A CASE STUDY OF SCIENTIFIC ANOMALY..............................................................................................................61 3.1 Introduction...............................................................................................................61 3.2 Overview of Hormesis Research ..............................................................................65 3.3 Analysis of the Hormesis Anomaly Relative to Previous Descriptive Conclusions 84 3.4 Analysis of the Hormesis Anomaly Relative to Previous Explanatory Conclusions.............................................................................................................116 3.5 Significance of the Chapter’s Analysis of the Hormesis Case ...............................128 3.6 Conclusion ..............................................................................................................134 CHAPTER 4: A DIACHRONIC ACCOUNT OF ANOMALY .....................................135 4.1 Introduction.............................................................................................................135 4.2 Motivation and Methodology for Developing Account D......................................136 4.3 Argument for Account D ........................................................................................145 4.4 Significance of Account D......................................................................................173 4.5 Conclusion ..............................................................................................................193 CHAPTER 5: CHEMICAL HORMESIS AND THE IS/OUGHT DISTINCTION........195 5.1 Introduction.............................................................................................................195 5.2 Reconstruction of Claim R .....................................................................................197 5.3 Background on the NF and the IOD .......................................................................226 5.4 Eight Objections to Moore’s Description of the NF...............................................234 5.5 An Alternative Formulation of the NF ...................................................................242 iii 5.6 The Connection Between NF* and IOD.................................................................260 5.7 Conclusion ..............................................................................................................271 CHAPTER 6: CHEMICAL HORMESIS, PUBLIC HEALTH, AND CONSENT.........274 6.1 Introduction.............................................................................................................274 6.2 Four Problems with Claim R ..................................................................................276 6.3 An Ethical Lesson From the Hormesis Case ..........................................................317 6.4 Conclusion ..............................................................................................................356 CHAPTER 7: CONCLUSIONS AND FUTURE DIRECTIONS ...................................358 7.1 Introduction.............................................................................................................358 7.2 Philosophy of Science.............................................................................................359 7.3 Ethics ......................................................................................................................362 7.4 Chemical Hormesis.................................................................................................367 7.5 Conclusion ..............................................................................................................369 APPENDIX 1: CHARACTERIZATIONS OF THE HORMESIS ANOMALY ............370 APPENDIX 2: CHARACTERIZATIONS OF THE ENDOCRINE-DISRUPTION ANOMALY............................................................................................................377 APPENDIX 3: CHARACTERIZATIONS OF THE MULTIPLE-CHEMICAL- SENSITIVTY ANOMALY....................................................................................380 BIBLIOGRAPHY............................................................................................................385 iv ACKNOWLEDGMENTS I would like to thank Don Howard, the director of the Program in History and Philosophy of Science at the University of Notre Dame, for his diligent leadership of the program throughout my time here. His enthusiasm encouraged me to come to Notre Dame. I am also grateful for two fellowships that I received for my graduate study: a Notre Dame Presidential Fellowship and a Pew Younger Scholars Fellowship from the Pew Charitable Trusts. I would also like to thank several faculty members who have been particularly helpful throughout my graduate career. Ernan McMullin has been a consistent source of encouragement, abundant