The Epithelium
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Functional Anatomy of the Hypothalamic–Pituitary–Gonadal Axis and 1 the Male Reproductive Tract
Cambridge University Press 978-1-107-01212-7 - Fertility Preservation in Male Cancer Patients Editor-in-Chief John P. Mulhall Excerpt More information Section 1 Anatomy and physiology Chapter Functional anatomy of the hypothalamic–pituitary–gonadal axis and 1 the male reproductive tract Nelson E. Bennett Jr. Anatomy of reproductive function The reproductive functional axis of the male can be divided into three major subdivisions: (1) the hypo- thalamus, (2) the pituitary gland, and (3) the testis. Each level elaborates a signal, or transmitter molecule, that stimulates or inhibits the subsequent level of the axis. The end result is the production and expulsion of semen that contains spermatozoa. This chapter exam- ines the hypothalamic–pituitary–gonadal (HPG) axis, and reviews the functional anatomy of the testis, epi- didymis, vas deferens, seminal vesicles, prostate, and penis. Hypothalamus and anterior pituitary gland The control of male sexual and reproductive func- tion begins with secretion of gonadotropin-releasing hormone (GnRH) by the hypothalamus (Fig. 1.1). This hormone in turn stimulates the anterior pituitary gland to secrete two downstream hormones (termed gonadotropins). These hormones are luteinizing hor- mone (LH) and follicle-stimulating hormone (FSH). LH is the primary stimulus for the testicular secre- tion of testosterone, while FSH mainly stimulates spermatogenesis. Gonadotropin-releasing hormone (GnRH) Figure 1.1. Feedback regulation of the hypothalamic– The neuronal cells of the arcuate nuclei of the hypo- pituitary–gonadal (HPG) axis in males. Positive (stimulatory) effects are shown by + and inhibitory (negative feedback) effects by –. thalamus secrete GnRH, a 10-amino-acid peptide. The GnRH, gonadotropin-releasing hormone; LH, luteinizing hormone; endingsoftheseneuronsterminateinthemedian FSH, follicle-stimulating hormone. -
Sonography of the Scrotum
1 Sonography of the Scrotum Chee-Wai Mak and Wen-Sheng Tzeng Department of Medical Imaging, Chi Mei Medical Center, Tainan, Taiwan Central Taiwan University of Science and Technology, Taichung, Taiwan Chung Hwa University of Medical Technology, Tainan, Taiwan Republic of China 1. Introduction Although the development of new imaging modality such as computerized tomography and magnetic resonance imaging have open a new era for medical imaging, high resolution sonography remains as the initial imaging modality of choice for evaluation of scrotal disease. Many of the disease processes, such as testicular torsion, epididymo-orchitis, and intratesticular tumor, produce the common symptom of pain at presentation, and differentiation of these conditions and disorders is important for determining the appropriate treatment. High resolution ultrasound helps in better characterize some of the intrascrotal lesions, and suggest a more specific diagnosis, resulting in more appropriate treatments and avoiding unnecessary operation for some of the diseases. 2. Imaging technique For any scrotal examination, thorough palpation of the scrotal contents and history taking should precede the sonographic examination. Patients are usually examined in the supine position with a towel draped over his thighs to support the scrotum. Warm gel should always be used because cold gel can elicit a cremasteric response resulting in thickening of the scrotal wall; hence a thorough examination is difficult to be performed. A high resolution, near-focused, linear array transducer with a frequency of 7.5 MHz or greater is often used because it provides increased resolutions of the scrotal contents. Images of both scrotum and bilateral inguinal regions are obtained in both transverse and longitudinal planes. -
Te2, Part Iii
TERMINOLOGIA EMBRYOLOGICA Second Edition International Embryological Terminology FIPAT The Federative International Programme for Anatomical Terminology A programme of the International Federation of Associations of Anatomists (IFAA) TE2, PART III Contents Caput V: Organogenesis Chapter 5: Organogenesis (continued) Systema respiratorium Respiratory system Systema urinarium Urinary system Systemata genitalia Genital systems Coeloma Coelom Glandulae endocrinae Endocrine glands Systema cardiovasculare Cardiovascular system Systema lymphoideum Lymphoid system Bibliographic Reference Citation: FIPAT. Terminologia Embryologica. 2nd ed. FIPAT.library.dal.ca. Federative International Programme for Anatomical Terminology, February 2017 Published pending approval by the General Assembly at the next Congress of IFAA (2019) Creative Commons License: The publication of Terminologia Embryologica is under a Creative Commons Attribution-NoDerivatives 4.0 International (CC BY-ND 4.0) license The individual terms in this terminology are within the public domain. Statements about terms being part of this international standard terminology should use the above bibliographic reference to cite this terminology. The unaltered PDF files of this terminology may be freely copied and distributed by users. IFAA member societies are authorized to publish translations of this terminology. Authors of other works that might be considered derivative should write to the Chair of FIPAT for permission to publish a derivative work. Caput V: ORGANOGENESIS Chapter 5: ORGANOGENESIS -
Impotence Due to External Iliac Steal Syndrome
Case Report http://dx.doi.org/10.3348/kjr.2013.14.1.81 pISSN 1229-6929 · eISSN 2005-8330 Korean J Radiol 2013;14(1):81-85 Impotence due to External Iliac Steal Syndrome: Treatment with Percutaneous Transluminal Angioplasty and Stent Placement Serkan Gür, MD1, Levent Oguzkurt, MD2, Bilal Kaya, MD2, Güven Tekbas, MD2, Ugur Ozkan, MD2 1Sifa University, Department of Radiology, 35240 Basmane, Izmir, Turkey; 2Baskent University, Faculty of Medicine, Department of Radiology, 01250, Yüregir, Adana, Turkey We report a case of erectile dysfunction caused by external iliac artery occlusion, associated with pelvic steal syndrome; bilateral internal iliac arteries were patent. The patient stated that he had experienced erectile dysfunction at similar times along with claudication, but he did not mention it before angiography. He expressed that the erectile dysfunction did not last long and that he felt completely okay after the interventional procedure, in addition to his claudication. Successful treatment of the occlusion, by percutaneous transluminal angioplasty and stent implantation, helped resolve erectile dysfunction completely and treat the steal syndrome. Index terms: Erectile dysfunction; Pelvic steal syndrome; Percutaneous angioplasty INTRODUCTION and obstructive disease of the penile arteries are two main vascular causes of impotence. Obstructive arterial diseases Erectile dysfunction (ED) affects 10% of men between cause impotence by obstructing blood supply to the penis, the ages of 40 and 70 (1). ED includes multiple negative and impotence also occurs when the rare entities do not consequences; it was once believed to be a primarily obstruct the blood flow to the penis rather divert blood flow psychological problem. However, it has been estimated away from it. -
Male Sexual Impotence: a Case Study in Evaluation and Treatment
FAMILY PRACTICE GRAND ROUNDS Male Sexual Impotence: A Case Study in Evaluation and Treatment John G. Halvorsen, MD, MS, Craig Mommsen, MD, James A. Moriarty, MD, David Hunter, MD, Michael Metz, PhD, and Paul Lange, MD Minneapolis, Minnesota R. JOHN HALVORSEN {Assistant Professor, De cavernosa. There is also a very important suspensory lig D partment o f Family Practice and Community ament—a triangular structure attached at the base of the Health)-. Male sexual impotence is the inability to obtain penis and to the pubic arch blending with Buck’s fascia and sustain an erection adequate to permit satisfactory around the penis—that is responsible for forming the angle penetration and completion of sexual intercourse. Im of the erect penis. potence is defined as primary if erections have never oc The arterial supply to the penis flows from the aorta curred, and secondary if they have previously occurred through the common iliac, hypogastric, and internal pu but subsequently have ceased. The cause of sexual im dendal systems. The artery of the penis is a branch of the potence may be psychogenic, organic, or mixed. In the internal pudendal artery and has four branches. The first past, the common belief was that 90 percent of impotence branch, the artery to the bulb, supplies the corpus spon was psychological.1,2 Recent research indicates, however, giosum, the glans, and the bulb. The second branch is the that over one half of men with impotence suffer from an urethral artery. The artery of the penis then terminates organic disorder, although often there is considerable into the dorsal artery of the penis (which supplies the deep overlap between both psychological and organic causes.3,4 fascia, the penile skin, and the frenulum) and the deep or A knowledge of the anatomy of the penis and the com profunda branch (which supplies the corpora cavernosa plex physiology of erection is necessary to understand the on each side). -
Scrotal Ultrasound
Scrotal Ultrasound Bruce R. Gilbert, MD, PhD Associate Clinical Professor of Urology & Reproductive Medicine Weill Cornell Medical College Director, Reproductive and Sexual Medicine Smith Institute For Urology North Shore LIJ Health System 1 Developmental Anatomy" Testis and Kidney Hindgut Allantois In the 3-week-old embryo the Primordial primordial germ cells in the wall of germ cells the yolk sac close to the attachment of the allantois migrate along the Heart wall of the hindgut and the dorsal Genital Ridge mesentery into the genital ridge. Yolk Sac Hindgut At 5-weeks the two excretory organs the pronephros and mesonephros systems regress Primordial Pronephric system leaving only the mesonephric duct. germ cells (regressing) Mesonephric The metanephros (adult kidney) system forms from the metanephric (regressing) diverticulum (ureteric bud) and metanephric mass of mesoderm. The ureteric bud develops as a dorsal bud of the mesonephric duct Cloaca near its insertion into the cloaca. Mesonephric Duct Mesonephric Duct Ureteric Bud Ureteric Bud Metanephric system Metanephric system 2 Developmental Anatomy" Wolffian and Mullerian DuctMesonephric Duct Under the influence of SRY, cells in the primitive sex cords differentiate into Sertoli cells forming the testis cords during week 7. Gonads Mesonephros It is at puberty that these testis cords (in Paramesonephric association with germ cells) undergo (Mullerian) Duct canalization into seminiferous tubules. Mesonephric (Wolffian) Duct At 7 weeks the indifferent embryo also has two parallel pairs of genital ducts: the Mesonephric (Wolffian) and the Paramesonephric (Mullerian) ducts. Bladder Bladder Mullerian By week 8 the developing fetal testis tubercle produces at least two hormones: Metanephros 1. A glycoprotein (MIS) produced by the Ureter Uterovaginal fetal Sertoli cells (in response to SRY) primordium Rectum which suppresses unilateral development of the Paramesonephric (Mullerian) duct 2. -
Male Reproductive System
MALE REPRODUCTIVE SYSTEM DR RAJARSHI ASH M.B.B.S.(CAL); D.O.(EYE) ; M.D.-PGT(2ND YEAR) DEPARTMENT OF PHYSIOLOGY CALCUTTA NATIONAL MEDICAL COLLEGE PARTS OF MALE REPRODUCTIVE SYSTEM A. Gonads – Two ovoid testes present in scrotal sac, out side the abdominal cavity B. Accessory sex organs - epididymis, vas deferens, seminal vesicles, ejaculatory ducts, prostate gland and bulbo-urethral glands C. External genitalia – penis and scrotum ANATOMY OF MALE INTERNAL GENITALIA AND ACCESSORY SEX ORGANS SEMINIFEROUS TUBULE Two principal cell types in seminiferous tubule Sertoli cell Germ cell INTERACTION BETWEEN SERTOLI CELLS AND SPERM BLOOD- TESTIS BARRIER • Blood – testis barrier protects germ cells in seminiferous tubules from harmful elements in blood. • The blood- testis barrier prevents entry of antigenic substances from the developing germ cells into circulation. • High local concentration of androgen, inositol, glutamic acid, aspartic acid can be maintained in the lumen of seminiferous tubule without difficulty. • Blood- testis barrier maintains higher osmolality of luminal content of seminiferous tubules. FUNCTIONS OF SERTOLI CELLS 1.Germ cell development 2.Phagocytosis 3.Nourishment and growth of spermatids 4.Formation of tubular fluid 5.Support spermiation 6.FSH and testosterone sensitivity 7.Endocrine functions of sertoli cells i)Inhibin ii)Activin iii)Follistatin iv)MIS v)Estrogen 8.Sertoli cell secretes ‘Androgen binding protein’(ABP) and H-Y antigen. 9.Sertoli cell contributes formation of blood testis barrier. LEYDIG CELL • Leydig cells are present near the capillaries in the interstitial space between seminiferous tubules. • They are rich in mitochondria & endoplasmic reticulum. • Leydig cells secrete testosterone,DHEA & Androstenedione. • The activity of leydig cell is different in different phases of life. -
The Incidence and Anatomy of Accessory Pudendal Arteries As
The Incidence and Anatomy of Accessory Pudendal Arteries as Depicted on Multidetector-Row CT Angiography: Clinical Implications of Preoperative Evaluation for Laparoscopic and Robot-Assisted Radical Prostatectomy Beom Jin Park, MD1 Objective: To help preserve accessory pudendal arteries (APAs) and to Deuk Jae Sung, MD1 ensure optimal postoperative sexual function after a laparoscopic or robot-assist- Min Ju Kim, MD1 ed radical prostatectomy, we have evaluated the incidence of APAs as detected Sung Bum Cho, MD1 on multidetector-row CT (MDCT) angiography and have provided a detailed 1 Yun Hwan Kim, MD anatomical description. Kyoo Byung Chung, MD1 Materials and Methods: The distribution of APAs was evaluated in 121 con- Seok Ho Kang, MD2 secutive male patients between February 2006 and July 2007 who underwent 64- Jun Cheon, MD2 channel MDCT angiography of the lower extremities. We defined an APA as any artery located within the periprostatic region running parallel to the dorsal vascu- lar complex. We also subclassified APAs into lateral and apical APAs. Two radiol- ogists retrospectively evaluated the origin, course and number of APAs; the final Index terms: Accessory pudendal arteries APA subclassification based on MDCT angiography source data was determined Computed tomography (CT) by consensus. Angiography Results: We identified 44 APAs in 36 of 121 patients (30%). Two distinct vari- Laparoscopy Prostatectomy eties of APAs were identified. Thirty-three APAs (75%) coursed near the antero- lateral region of the prostatic apex, termed apical APAs. The remaining 11 APAs DOI:10.3348/kjr.2009.10.6.587 (25%) coursed along the lateral aspect of the prostate, termed lateral APAs. -
Ultrasonography of the Scrotum in Adults
University of Massachusetts Medical School eScholarship@UMMS Radiology Publications and Presentations Radiology 2016-07-01 Ultrasonography of the scrotum in adults Anna L. Kuhn University of Massachusetts Medical School Et al. Let us know how access to this document benefits ou.y Follow this and additional works at: https://escholarship.umassmed.edu/radiology_pubs Part of the Male Urogenital Diseases Commons, Radiology Commons, Reproductive and Urinary Physiology Commons, Urogenital System Commons, and the Urology Commons Repository Citation Kuhn AL, Scortegagna E, Nowitzki KM, Kim YH. (2016). Ultrasonography of the scrotum in adults. Radiology Publications and Presentations. https://doi.org/10.14366/usg.15075. Retrieved from https://escholarship.umassmed.edu/radiology_pubs/173 Creative Commons License This work is licensed under a Creative Commons Attribution-Noncommercial 3.0 License This material is brought to you by eScholarship@UMMS. It has been accepted for inclusion in Radiology Publications and Presentations by an authorized administrator of eScholarship@UMMS. For more information, please contact [email protected]. Ultrasonography of the scrotum in adults Anna L. Kühn, Eduardo Scortegagna, Kristina M. Nowitzki, Young H. Kim Department of Radiology, UMass Memorial Medical Center, University of Massachusetts Medical Center, Worcester, MA, USA REVIEW ARTICLE Ultrasonography is the ideal noninvasive imaging modality for evaluation of scrotal http://dx.doi.org/10.14366/usg.15075 abnormalities. It is capable of differentiating the most important etiologies of acute scrotal pain pISSN: 2288-5919 • eISSN: 2288-5943 and swelling, including epididymitis and testicular torsion, and is the imaging modality of choice Ultrasonography 2016;35:180-197 in acute scrotal trauma. In patients presenting with palpable abnormality or scrotal swelling, ultrasonography can detect, locate, and characterize both intratesticular and extratesticular masses and other abnormalities. -
Scrotal Ultrasound CONTENT ANATOMY
12/04/2021 Scrotal Ultrasound Scrotal Ultrasound Paul S. Sidhu CONTENT Professor of Imaging Sciences King’s College Hospital London Scrotal Ultrasound Lecture Content • Background Anatomy • Normal Variants • Extra-testicular pathology • Intra-testicular pathology • Global Abnormalities Scrotal Ultrasound • New US techniques ANATOMY Scrotal Ultrasound Scrotal Ultrasound Anatomy Vascular Anatomy • Testicular artery Low vascular resistance Broad systolic peak High diastolic flow • Cremasteric artery and artery to ductus deferens Epididymis/Peri-testicular tissues Narrower systolic peak Low diastolic flow Aziz ZA, Satchithananda K, Khan M, Sidhu PS. High Frequency Colour Doppler Ultrasound of the Spermatic Cord Arteries: Resistive Index Variation in a Cohort of 51 Healthy Men. Journal of Ultrasound in Medicine 2005;24:905-909. 1 12/04/2021 Scrotal Ultrasound Vascular Anatomy • Pampiniform plexus • Cremasteric plexus • Testicular vein Scrotal Ultrasound NORMAL VARIANTS Scrotal Ultrasound Scrotal Ultrasound Normal Variants Normal Variants Torsion of an Appendix Testis • Testicular appendages are remnants of the paramesonephric ducts, found at the upper pole of the testes in a groove between the testis and the head of the • Age range 7-12 years epididymis. • ‘Blue dot’ sign on a fair skin. • Similar reflectivity to the epididymal head and ovoid shaped, may be cystic. • Torsion of a testicular appendix is a common cause for scrotal pain in children. • Appendix is usually sessile but may be pedunculated and sometimes calcifies. • The presenting features of appendicular torsion and testicular torsion are often similar, • Seen in 92% of post mortems, 90% of cases are appendix testis • Infarcted appendix may form a scrotal pearl though pain localised to the upper pole of the testicle and a tender nodule are suggestive of a torsed appendix. -
Vascularization of the Penis of a Man
Roczniki Akademii Medycznej w Białymstoku · Vol. 49, 2004 · Annales Academiae MedicaeVascularization Bialostocensis of the penis of a man 285 Vascularization of the penis of a man Okolokulak E, Volchkevich D The Human Anatomy Department, Grodno State Medical University, Grodno, Belarus Abstract Conclusions: The penis receives blood from external and internal pudendal arteries, which are very variable. The Purpose: The study of the features of the blood supply of venous blood of the penis flows off in three types of veins. a penis of the man. Material and methods: Macromicropreparation, angio- graphy, corrosion method, morphometry, statistical method. Key words: penis, veins of penis, arteries of penis, erectile Results: The penis has three venous collector-execut- dysfunction. ing outflow of blood. First of them is submitted surface dorsal vein, which is shaped from small-sized venous ves- sels of skin, subcutaneous fat and surface fascia of penis. Introduction The beginning deep dorsal vein, which will derivate second venous collector, gives veniplex of head of the penis. The The development of the medical technology has deepened spongy veins outstanding as third venous collector, reach the knowledge of organic violations of gears of erection. It was the bulb of penis, where they receive small-sized bulbar vein. straightened out, that more than 50% from them cause vascular The arterial blood supply of penis happens at the expense of disorders [1-4]. It has given a particular push to more detailed external and internal pudendal arteries. The external puden- learning extra- and intraorgans vessels of the penis. At the same dal artery starts from an internal wall of femoral artery on time, the problems of vascularization and relationships of blood 2.5-2.7 cm below inguinal ligament. -
Clinical Pelvic Anatomy
SECTION ONE • Fundamentals 1 Clinical pelvic anatomy Introduction 1 Anatomical points for obstetric analgesia 3 Obstetric anatomy 1 Gynaecological anatomy 5 The pelvic organs during pregnancy 1 Anatomy of the lower urinary tract 13 the necks of the femora tends to compress the pelvis Introduction from the sides, reducing the transverse diameters of this part of the pelvis (Fig. 1.1). At an intermediate level, opposite A thorough understanding of pelvic anatomy is essential for the third segment of the sacrum, the canal retains a circular clinical practice. Not only does it facilitate an understanding cross-section. With this picture in mind, the ‘average’ of the process of labour, it also allows an appreciation of diameters of the pelvis at brim, cavity, and outlet levels can the mechanisms of sexual function and reproduction, and be readily understood (Table 1.1). establishes a background to the understanding of gynae- The distortions from a circular cross-section, however, cological pathology. Congenital abnormalities are discussed are very modest. If, in circumstances of malnutrition or in Chapter 3. metabolic bone disease, the consolidation of bone is impaired, more gross distortion of the pelvic shape is liable to occur, and labour is likely to involve mechanical difficulty. Obstetric anatomy This is termed cephalopelvic disproportion. The changing cross-sectional shape of the true pelvis at different levels The bony pelvis – transverse oval at the brim and anteroposterior oval at the outlet – usually determines a fundamental feature of The girdle of bones formed by the sacrum and the two labour, i.e. that the ovoid fetal head enters the brim with its innominate bones has several important functions (Fig.