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Cyclic Aliphatic Bromine Cluster (HBCD): Supplemental Document to the TSCA Scope Document

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Cyclic Aliphatic Bromine Cluster (HBCD): Supplemental Document to the TSCA Scope Document United States June 2017 Environmental Protection Agency Office of Chemical Safety and Pollution Prevention Strategy for Conducting Literature Searches for Cyclic Aliphatic Bromine Cluster (HBCD): Supplemental Document to the TSCA Scope Document CASRN: 25637-99-4 3194-55-6 3194-57-8 June 2017 TABLE OF CONTENTS TABLE OF CONTENTS ......................................................................................................................... 2 1 OVERALL APPROACH .................................................................................................................. 5 2 STEP 1: DEFINE SPECIFIC OBJECTIVES FOR THE SEARCHES ........................................................... 6 3 STEP 2: DEVELOP SEARCH STRATEGIES........................................................................................ 8 3.1 SEARCH STRATEGIES FOR PHYSICAL/CHEMICAL PROPERTIES ..................................................................................................... 9 3.2 SEARCH STRATEGIES FOR CONDITIONS OF USE .................................................................................................................... 10 3.3 SEARCH STRATEGIES FOR FATE, ENGINEERING/OCCUPATIONAL EXPOSURE, EXPOSURE, AND HUMAN HEALTH HAZARD..................... 10 3.3.1 Use of Existing Assessments ................................................................................................................................. 10 3.3.2 Peer-Reviewed Literature Database Search Strategies ........................................................................................ 11 3.3.3 Gray Literature Search Strategies ......................................................................................................................... 12 3.3.4 Initial Lifecycle/Conceptual Model Targeted Search ............................................................................................ 12 3.4 SEARCH STRATEGIES FOR ENVIRONMENTAL HAZARD ............................................................................................................ 13 4 STEP 3 AND 4: DEVELOP INCLUSION/EXCLUSION CRITERIA AND TAGS TO CATEGORIZE SEARCH RESULTS .......................................................................................................................................... 13 4.1 INCLUSION/EXCLUSION CRITERIA FOR PHYSICAL/CHEMICAL PROPERTIES .................................................................................. 13 4.2 INCLUSION/EXCLUSION CRITERIA FOR CONDITIONS OF USE ................................................................................................... 13 4.3 INCLUSION/EXCLUSION CRITERIA AND TAGS FOR FATE, ENGINEERING/OCCUPATIONAL EXPOSURE, EXPOSURE, AND HUMAN HEALTH HAZARD 14 4.4 INCLUSION/EXCLUSION CRITERIA FOR FATE, ENGINEERING/OCCUPATIONAL EXPOSURE, EXPOSURE, AND HUMAN HEALTH HAZARD GRAY LITERATURE ............................................................................................................................................................................... 15 4.5 INCLUSION/EXCLUSION CRITERIA AND TAGS FOR ENVIRONMENTAL HAZARD ............................................................................. 16 5 STEP 5: SCREEN SEARCH RESULTS ............................................................................................. 16 5.1 SCREENING AND TAGGING FOR PHYSICAL/CHEMICAL PROPERTIES ........................................................................................... 16 5.2 SCREENING AND TAGGING FOR CONDITIONS OF USE ............................................................................................................ 16 5.3 SCREENING AND TAGGING FOR FATE, ENGINEERING/OCCUPATIONAL EXPOSURE, EXPOSURE, AND HUMAN HEALTH HAZARD ............. 16 5.3.1 Peer-Reviewed Literature Database Search Results ............................................................................................. 16 5.3.2 Gray Literature Search Results ............................................................................................................................. 17 5.4 SCREENING AND TAGGING FOR ENVIRONMENTAL HAZARD .................................................................................................... 17 6 STEP 6. QUALITY ASSESSMENT PROCEDURE FOR SCREENING AND TAGGING ............................. 17 APPENDICES .................................................................................................................................... 18 A. LITERATURE SEARCH INFORMATION NEEDS FOR CYCLIC ALIPHATIC BROMINE CLUSTER (HBCD) 18 FATE INFORMATION NEEDS ........................................................................................................................................... 18 ENGINEERING/OCCUPATIONAL EXPOSURE INFORMATION NEEDS .......................................................................................... 18 EXPOSURE INFORMATION NEEDS .................................................................................................................................... 19 HUMAN HEALTH INFORMATION NEEDS ............................................................................................................................ 20 B. DATABASE (PEER-REVIEWED) LITERATURE SEARCHES FOR FATE, ENGINEERING/OCCUPATIONAL EXPOSURE, EXPOSURE, AND HUMAN HEALTH HAZARD ................................................................... 21 LITERATURE SEARCH STRATEGY FROM THE DRAFT CYCLIC ALIPHATIC BROMINE CLUSTER (HBCD) IRIS ASSESSMENT ...................... 21 CYCLIC ALIPHATIC BROMINE CLUSTER (HBCD) SYNONYMS .................................................................................................. 29 LITERATURE SEARCH STRATEGIES FOR DATABASE LITERATURE SEARCHES FOR FATE, ENGINEERING/OCCUPATIONAL EXPOSURE, AND EXPOSURE 31 Page 2 of 101 LITERATURE SEARCH STRATEGIES FOR DATABASE LITERATURE SEARCHES FOR HUMAN HEALTH ................................................... 34 C. GRAY LITERATURE SEARCHES FOR FATE, ENGINEERING/OCCUPATIONAL EXPOSURE, EXPOSURE, AND HUMAN HEALTH HAZARD........................................................................................................ 41 D. LITERATURE SEARCHES FOR ENVIRONMENTAL HAZARD ........................................................... 75 E. DEVELOPMENT OF TAGS WITH INCLUSION/EXCLUSION CRITERIA ............................................. 88 INCLUSION/EXCLUSION CRITERIA AND TAGS FOR THE FATE LITERATURE .................................................................................. 88 INCLUSION/EXCLUSION CRITERIA AND TAGS FOR THE ENGINEERING/OCCUPATIONAL EXPOSURE LITERATURE ................................ 91 INCLUSION/EXCLUSION CRITERIA AND TAGS FOR THE EXPOSURE LITERATURE .......................................................................... 93 INCLUSION/EXCLUSION CRITERIA AND TAGS FOR THE HUMAN HEALTH HAZARD LITERATURE ...................................................... 96 INCLUSION/EXCLUSION CRITERIA FOR THE ENVIRONMENTAL HAZARD LITERATURE ................................................................... 99 LIST OF TABLES Table 2-1. Overview of Literature Search for Cyclic Aliphatic Bromine Cluster (HBCD) across All Topic Areas ........................................................................................................................................................... 7 Table 3-1. Overview of Search Strategies for Cyclic Aliphatic Bromine Cluster (HBCD) by Topic Area and Source Type ................................................................................................................................................. 8 Table_Apx A-1. Fate Information Needs for Cyclic Aliphatic Bromine Cluster (HBCD) ............................ 18 Table_Apx A-2. Engineering/Occupational Exposure Information Needs for Cyclic Aliphatic Bromine Cluster (HBCD) .......................................................................................................................................... 18 Table_Apx A-3. Exposure Information Needs for Cyclic Aliphatic Bromine Cluster (HBCD) .................... 19 Table_Apx A-4. Human Health Information Needs for Cyclic Aliphatic Bromine Cluster (HBCD) ............ 20 Table_Apx B-1. Literature search query strings from the draft Cyclic Aliphatic Bromine Cluster (HBCD) IRIS Assessment ........................................................................................................................................ 21 Table_Apx B-2. Processes used in the Draft Cyclic Aliphatic Bromine Cluster (HBCD) IRIS Assessment to Augment the Search of Core Computerized Databases for HBCD ........................................................... 26 Table_Apx B-3. HBCD Fate, Engineering/Occupational Exposure, and Exposure Search Strategy for Web of Science .................................................................................................................................................. 31 Table_Apx B-4. Cyclic Aliphatic Bromine Cluster (HBCD) Human Health Hazard Peer-Reviewed Literature Search Strategy ........................................................................................................................ 34 Table_Apx C-1. Overview of Search Strategy for Gray Literature for Fate, Engineering/Occupational Exposure, Exposure, and Human Health Hazard Topic Areas .................................................................. 42 Table_Apx C-2. Sources Used For Gray Literature Search for Fate, Engineering/Occupational Exposure, Exposure, and Human Health Hazard Topic Areas with Source-Specific Inclusion/Exclusion Criteria ...
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