United States June 2017 Environmental Protection Agency Office of Chemical Safety and Pollution Prevention Strategy for Conducting Literature Searches for Cyclic Aliphatic Bromine Cluster (HBCD): Supplemental Document to the TSCA Scope Document CASRN: 25637-99-4 3194-55-6 3194-57-8 June 2017 TABLE OF CONTENTS TABLE OF CONTENTS ......................................................................................................................... 2 1 OVERALL APPROACH .................................................................................................................. 5 2 STEP 1: DEFINE SPECIFIC OBJECTIVES FOR THE SEARCHES ........................................................... 6 3 STEP 2: DEVELOP SEARCH STRATEGIES........................................................................................ 8 3.1 SEARCH STRATEGIES FOR PHYSICAL/CHEMICAL PROPERTIES ..................................................................................................... 9 3.2 SEARCH STRATEGIES FOR CONDITIONS OF USE .................................................................................................................... 10 3.3 SEARCH STRATEGIES FOR FATE, ENGINEERING/OCCUPATIONAL EXPOSURE, EXPOSURE, AND HUMAN HEALTH HAZARD..................... 10 3.3.1 Use of Existing Assessments ................................................................................................................................. 10 3.3.2 Peer-Reviewed Literature Database Search Strategies ........................................................................................ 11 3.3.3 Gray Literature Search Strategies ......................................................................................................................... 12 3.3.4 Initial Lifecycle/Conceptual Model Targeted Search ............................................................................................ 12 3.4 SEARCH STRATEGIES FOR ENVIRONMENTAL HAZARD ............................................................................................................ 13 4 STEP 3 AND 4: DEVELOP INCLUSION/EXCLUSION CRITERIA AND TAGS TO CATEGORIZE SEARCH RESULTS .......................................................................................................................................... 13 4.1 INCLUSION/EXCLUSION CRITERIA FOR PHYSICAL/CHEMICAL PROPERTIES .................................................................................. 13 4.2 INCLUSION/EXCLUSION CRITERIA FOR CONDITIONS OF USE ................................................................................................... 13 4.3 INCLUSION/EXCLUSION CRITERIA AND TAGS FOR FATE, ENGINEERING/OCCUPATIONAL EXPOSURE, EXPOSURE, AND HUMAN HEALTH HAZARD 14 4.4 INCLUSION/EXCLUSION CRITERIA FOR FATE, ENGINEERING/OCCUPATIONAL EXPOSURE, EXPOSURE, AND HUMAN HEALTH HAZARD GRAY LITERATURE ............................................................................................................................................................................... 15 4.5 INCLUSION/EXCLUSION CRITERIA AND TAGS FOR ENVIRONMENTAL HAZARD ............................................................................. 16 5 STEP 5: SCREEN SEARCH RESULTS ............................................................................................. 16 5.1 SCREENING AND TAGGING FOR PHYSICAL/CHEMICAL PROPERTIES ........................................................................................... 16 5.2 SCREENING AND TAGGING FOR CONDITIONS OF USE ............................................................................................................ 16 5.3 SCREENING AND TAGGING FOR FATE, ENGINEERING/OCCUPATIONAL EXPOSURE, EXPOSURE, AND HUMAN HEALTH HAZARD ............. 16 5.3.1 Peer-Reviewed Literature Database Search Results ............................................................................................. 16 5.3.2 Gray Literature Search Results ............................................................................................................................. 17 5.4 SCREENING AND TAGGING FOR ENVIRONMENTAL HAZARD .................................................................................................... 17 6 STEP 6. QUALITY ASSESSMENT PROCEDURE FOR SCREENING AND TAGGING ............................. 17 APPENDICES .................................................................................................................................... 18 A. LITERATURE SEARCH INFORMATION NEEDS FOR CYCLIC ALIPHATIC BROMINE CLUSTER (HBCD) 18 FATE INFORMATION NEEDS ........................................................................................................................................... 18 ENGINEERING/OCCUPATIONAL EXPOSURE INFORMATION NEEDS .......................................................................................... 18 EXPOSURE INFORMATION NEEDS .................................................................................................................................... 19 HUMAN HEALTH INFORMATION NEEDS ............................................................................................................................ 20 B. DATABASE (PEER-REVIEWED) LITERATURE SEARCHES FOR FATE, ENGINEERING/OCCUPATIONAL EXPOSURE, EXPOSURE, AND HUMAN HEALTH HAZARD ................................................................... 21 LITERATURE SEARCH STRATEGY FROM THE DRAFT CYCLIC ALIPHATIC BROMINE CLUSTER (HBCD) IRIS ASSESSMENT ...................... 21 CYCLIC ALIPHATIC BROMINE CLUSTER (HBCD) SYNONYMS .................................................................................................. 29 LITERATURE SEARCH STRATEGIES FOR DATABASE LITERATURE SEARCHES FOR FATE, ENGINEERING/OCCUPATIONAL EXPOSURE, AND EXPOSURE 31 Page 2 of 101 LITERATURE SEARCH STRATEGIES FOR DATABASE LITERATURE SEARCHES FOR HUMAN HEALTH ................................................... 34 C. GRAY LITERATURE SEARCHES FOR FATE, ENGINEERING/OCCUPATIONAL EXPOSURE, EXPOSURE, AND HUMAN HEALTH HAZARD........................................................................................................ 41 D. LITERATURE SEARCHES FOR ENVIRONMENTAL HAZARD ........................................................... 75 E. DEVELOPMENT OF TAGS WITH INCLUSION/EXCLUSION CRITERIA ............................................. 88 INCLUSION/EXCLUSION CRITERIA AND TAGS FOR THE FATE LITERATURE .................................................................................. 88 INCLUSION/EXCLUSION CRITERIA AND TAGS FOR THE ENGINEERING/OCCUPATIONAL EXPOSURE LITERATURE ................................ 91 INCLUSION/EXCLUSION CRITERIA AND TAGS FOR THE EXPOSURE LITERATURE .......................................................................... 93 INCLUSION/EXCLUSION CRITERIA AND TAGS FOR THE HUMAN HEALTH HAZARD LITERATURE ...................................................... 96 INCLUSION/EXCLUSION CRITERIA FOR THE ENVIRONMENTAL HAZARD LITERATURE ................................................................... 99 LIST OF TABLES Table 2-1. Overview of Literature Search for Cyclic Aliphatic Bromine Cluster (HBCD) across All Topic Areas ........................................................................................................................................................... 7 Table 3-1. Overview of Search Strategies for Cyclic Aliphatic Bromine Cluster (HBCD) by Topic Area and Source Type ................................................................................................................................................. 8 Table_Apx A-1. Fate Information Needs for Cyclic Aliphatic Bromine Cluster (HBCD) ............................ 18 Table_Apx A-2. Engineering/Occupational Exposure Information Needs for Cyclic Aliphatic Bromine Cluster (HBCD) .......................................................................................................................................... 18 Table_Apx A-3. Exposure Information Needs for Cyclic Aliphatic Bromine Cluster (HBCD) .................... 19 Table_Apx A-4. Human Health Information Needs for Cyclic Aliphatic Bromine Cluster (HBCD) ............ 20 Table_Apx B-1. Literature search query strings from the draft Cyclic Aliphatic Bromine Cluster (HBCD) IRIS Assessment ........................................................................................................................................ 21 Table_Apx B-2. Processes used in the Draft Cyclic Aliphatic Bromine Cluster (HBCD) IRIS Assessment to Augment the Search of Core Computerized Databases for HBCD ........................................................... 26 Table_Apx B-3. HBCD Fate, Engineering/Occupational Exposure, and Exposure Search Strategy for Web of Science .................................................................................................................................................. 31 Table_Apx B-4. Cyclic Aliphatic Bromine Cluster (HBCD) Human Health Hazard Peer-Reviewed Literature Search Strategy ........................................................................................................................ 34 Table_Apx C-1. Overview of Search Strategy for Gray Literature for Fate, Engineering/Occupational Exposure, Exposure, and Human Health Hazard Topic Areas .................................................................. 42 Table_Apx C-2. Sources Used For Gray Literature Search for Fate, Engineering/Occupational Exposure, Exposure, and Human Health Hazard Topic Areas with Source-Specific Inclusion/Exclusion Criteria ...