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On-Line Table 1: Demographic Details No. Sex Age Schooling (Y) Education (WHOQOL)A Handedness Employment Status P1 Female 57

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On-Line Table 1: Demographic Details No. Sex Age Schooling (Y) Education (WHOQOL)A Handedness Employment Status P1 Female 57 On-line Table 1: Demographic details Schooling Education Employment No. Sex Age (y) (WHOQOL)a Handedness Status P1 Female 57 8 2 Right Retired P2 Male 35 13 7 Left Working P3 Female 37 12 3 Right Working P4 Male 50 10 2 Ambidext. Working P5 Female 43 9 2 Right Unemployed P6 Male 24 10 3 Right Working P7 Female 25 10 3 Right Working P8 Male 35 10 3 Right Working P9 Female 43 10 3 Right Working P10 Female 55 8 2 Right Working P11 Male 32 9 2 Right Working P12 Male 31 10 3 Right Working P13 Male 43 10 3 Right Working P14 Male 59 10 3 Right Working P15 Male 50 10 3 Right Working P16 Male 64 9 2 Right Retired P17 Female 33 9 2 Left Working P18 Male 66 8 1 Right Retired P19 Male 61 10 3 Right Retired P20 Female 49 10 3 Right Retired P21 Female 55 12 5 Right Working P22 Female 20 13 5 Right Working P23 Male 32 10 3 Right Working P24 Male 61 10 3 Right Working P25 Female 28 13 5 Right Working P26 Male 27 10 3 Ambidext. Working P27 Female 40 10 3 Right Working P28 Female 27 9 2 Right Working P29 Male 49 10 3 Right Working P30 Female 31 10 3 Right Working P31 Female 29 10 3 Right Working P32 Female 63 8 2 Right Working P33 Male 30 13 5 Right Working P34 Female 30 13 7 Right Working P35 Male 40 10 4 Left Working P36 Male 19 10 3 Right Sick leave P37 Male 47 13 7 Right Working P38 Female 26 10 4 Right Working P39 Male 24 10 3 Right Working P40 Male 57 8 2 Right Working P41 Male 68 13 7 Right Retired C1 Male 37 13 6 Left Working C2 Male 40 13 6 Right Working C3 Male 48 10 2 Right Working C4 Male 46 10 6 Ambidext. Working C5 Male 48 13 6 Right Working C6 Female 58 8 2 Right Working C7 Female 43 8 1 Right Working C8 Male 66 8 1 Left Retired C9 Female 59 8 1 Right Working C10 Female 43 10 3 Right Working C11 Male 33 13 4 Right Working C12 Female 62 10 3 Right Retired Note:—Demographic details of all enrolled participants (41 patients, 12 control participants) are shown. Age and sex were included into the VBM analysis as confounders of no interest WHOQOL indicates World Health Organization Quality of Life; P ϭ patients. a Educational level was classified according to WHOQOL-100 and WHOQOL-BREF (Angermeyer MC, Kilian R, Matschinger H. Go¨ttingen: Hogrefe-Verlag fu¨r Psychologie; 2000) ranging from 0 (no graduation) to 7 (postgraduate/PhD). C ϭ control participants; Ambidext., ambidextrous. AJNR Am J Neuroradiol : www.ajnr.org T1 On-line Table 2: Volumetric differences in patients with BM compared with control participants P (FWE) K T MNI Atlas Patients Ͻ Control Participants Ͻ.001 774 11.87 3 Ϫ12 25 Right cingulate gyrus (1%) 10.39 3 8 24 Right cingulate gyrus (17%) 7.28 Ϫ4 Ϫ10 19 Left thalamus (15%) Ͻ.001 208 10.47 10 11 19 Right caudate (28%) Ͻ.001 826 8.72 3 2 Ϫ21 No atlas label found (visually: right chiasma opticum/mamillary body) 8.01 30 Ϫ15 Ϫ8 Right putamen (15%) 6.80 15 Ϫ6 Ϫ11 Right amygdala (37%) Ͻ.001 800 8.03 Ϫ44 Ϫ31 10 Left planum temporale (67%) 6.31 Ϫ48 Ϫ37 18 Left planum temporale (45%) Ͻ.001 1145 7.84 Ϫ18 Ϫ30 Ϫ5 Left thalamus (17%) 6.95 Ϫ32 Ϫ27 Ϫ15 Left hippocampus (37%) 6.76 Ϫ26 Ϫ18 Ϫ8 Left amygdala (3%) Ͻ.001 7 7.00 12 Ϫ34 Ϫ45 Right brain stem (27%) .005 125 6.01 70 Ϫ12 Ϫ12 Right middle temporal gyrus, posterior division (29%) .010 15 5.75 Ϫ51 Ϫ31 Ϫ29 Left inferior temporal gyrus, posterior division (18%) .012 10 5.69 Ϫ54 Ϫ15 43 Left postcentral gyrus (70%) .020 1 5.52 Ϫ12 Ϫ36 Ϫ45 Left brain stem (10%) .020 36 5.52 22 27 61 Right superior frontal gyrus (60%) .029 25 5.39 57 Ϫ28 48 Right supramarginal gyrus, anterior division (67%) .035 14 5.33 69 Ϫ45 1 Right middle temporal gyrus (28%) .039 2 5.29 58 Ϫ36 40 Right supramarginal gyrus, posterior division (36%) .045 3 5.24 32 Ϫ81 Ϫ27 Right lateral occipital cortex (3%) .049 1 5.22 Ϫ10 Ϫ10 19 Left thalamus (44%) Patients Ͼ Control Participants Ͻ.001 210 8.55 Ϫ12 Ϫ27 Ϫ14 Left brain stem (59%) 5.66 Ϫ15 Ϫ25 Ϫ30 Left brain stem (99%) Ͻ.001 115 7.43 9 Ϫ30 Ϫ15 Right brain stem (92%) 5.77 14 Ϫ24 Ϫ12 Right brain stem (10%) Ͻ.001 96 7.29 4 Ϫ42 Ϫ32 Right brain stem (18%) Ͻ.001 300 6.94 30 26 Ϫ20 Right frontal orbital cortex (83%) Ͻ.001 78 6.76 Ϫ2 Ϫ16 Ϫ11 No atlas label found .002 237 6.26 10 Ϫ102 Ϫ12 Right occipital pole (14%) .003 25 6.20 30 Ϫ37 7 Right hippocampus (4%) .003 159 6.14 Ϫ10 65 Ϫ20 Left frontal pole (51%) .006 64 5.92 3 Ϫ87 Ϫ5 Right lingual gyrus (45%) .019 13 5.53 8 Ϫ43 Ϫ63 Right brain stem (45%) 5.50 0 Ϫ49 Ϫ63 Midline brain stem (32%) .026 11 5.44 Ϫ18 Ϫ49 13 Left precuneous cortex (3%) .047 1 5.23 27 10 Ϫ20 Right frontal orbital cortex (42%) Note:—Significant clusters and local maxima (Ͼ 8 mm apart) of volumetric differences (P Ͻ .05 FWE-corrected, peak level) between patients and healthy control participants are shown. Anatomic position was estimated with use of the FSL atlas tools; only the highest probability (value in parentheses) gray matter structure (or brain stem where applicable) is reported. FWE indicates family-wise error; P ϭ peak level FEW-corrected P value per cluster; k ϭ count of suprathreshold voxels per cluster; T ϭ maximal uncorrected t score per cluster; MNI ϭ coordinates (x, y and z) of cluster maximum in the Montreal Neurological Institute convention. T2 AJNR www.ajnr.org On-line Table 3: Results of the atlas-based analysis Corrected Region Controls Patients F P Value Left hippocampus 1.652 1.496 7.32 .029 Right hippocampus 1.424 1.300 8.00 .015 Left amygdala 0.914 0.851 3.73 n.s. Right amygdala 0.965 0.978 0.55 n.s. Left anterior temporal lobe, medial part 3.311 3.259 1.66 n.s. Right anterior temporal lobe, medial part 3.124 3.320 2.12 n.s. Left anterior temporal lobe, lateral part 2.228 2.090 2.88 n.s. Right anterior temporal lobe, lateral part 1.925 2.007 0.68 n.s. Left gyri parahippocampalis et ambiens 2.081 1.955 6.34 n.s. Right gyri parahippocampalis et ambiens 2.140 2.055 2.73 n.s. Left superior temporal gyrus, posterior part 5.084 4.890 1.97 n.s. Right superior temporal gyrus, posterior part 4.980 4.981 1.87 n.s. Left medial and inferior temporal gyri 7.891 6.934 10.48 .002 Right medial and inferior temporal gyri 7.137 7.086 1.19 n.s. Left lateral occipitotemporal gyrus (gyrus fusiformis) 2.102 2.134 0.41 n.s. Right lateral occipitotemporal gyrus (gyrus fusiformis) 2.134 2.184 0.85 n.s. Left cerebellum 31.072 31.155 2.29 n.s. Right cerebellum 30.732 31.020 1.77 n.s. Brain stem 2.288 2.389 14.53 Ͻ.001 Right insula 5.560 5.360 2.24 n.s. Left insula 5.617 5.671 1.29 n.s. Right occipital lobe 13.690 14.082 1.20 n.s. Left occipital lobe 13.368 14.615 6.82 .048 Right cingulate gyrus, anterior part 3.677 3.884 6.74 n.s. Left cingulate gyrus, anterior part 3.853 3.698 6.09 n.s. Right cingulate gyrus, posterior part 3.597 3.566 8.14 .013 Left cingulate gyrus, posterior part 3.417 3.467 6.25 n.s. Right middle frontal gyrus 14.539 15.047 12.68 Ͻ.001 Left middle frontal gyrus 15.109 15.257 11.10 .001 Right posterior temporal lobe 17.509 17.722 2.32 n.s. Left posterior temporal lobe 18.398 17.919 3.61 n.s. Right parietal lobe 14.261 13.880 12.42 Ͻ.001 Left parietal lobe 13.505 13.609 8.75 .007 Right caudate nucleus 1.977 2.060 1.09 n.s. Left caudate nucleus 2.061 1.896 4.07 n.s. Right nucleus accumbens 0.237 0.229 0.57 n.s. Left nucleus accumbens 0.184 0.184 0.60 n.s. Right putamen 1.444 1.350 3.02 n.s. Left putamen 1.441 1.356 1.36 n.s. Right thalamus 2.173 1.954 6.67 n.s. Left thalamus 2.015 1.975 1.10 n.s. Right pallidum 0.006 0.006 1.93 n.s. Left pallidum 0.007 0.009 2.09 n.s. Corpus callosum 1.434 1.142 17.55 Ͻ.001 Right precentral gyrus 7.656 7.741 4.45 n.s. Left precentral gyrus 7.332 7.660 3.78 n.s. Right straight gyrus 1.487 1.483 0.25 n.s. Left straight gyrus 1.758 1.669 1.54 n.s.
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