DOCSLIB.ORG

Dense Hyperthermic Intraperitoneal Chemotherapy with Cisplatin In

Total Page：16

File Type：pdf, Size：1020Kb

Download full-text PDF Read full-text
Dense Hyperthermic Intraperitoneal Chemotherapy with Cisplatin In He et al. BMC Cancer (2021) 21:738 https://doi.org/10.1186/s12885-021-08507-y RESEARCH ARTICLE Open Access Dense hyperthermic intraperitoneal chemotherapy with cisplatin in patients with stage III serous epithelial ovarian cancer: a retrospective study Xiaoli He1†, Li Wei1†, Rui Li1, Shuang Jing1, Linlin Jia1, Danwei Ji2, Yali Li1, Yue Wang1* and Yongxia Zhu1* Abstract Background: To investigate the efficacy and safety of interval debulking surgery (IDS) combined with dense hyperthermic intraperitoneal chemotherapy (HIPEC) with cisplatin in Chinese patients with FIGO stage III serous epithelial ovarian cancer (EOC). Methods: This retrospective single-center study reviewed the demographic and clinical data of 197 patients with primary FIGO stage III serous EOC who were treated with IDS with (n = 121) or without (n = 76, control group) dense HIPEC between January 2012 and April 2017. The co-primary endpoints were progression-free survival (PFS) and overall survival (OS), and the secondary endpoint was the occurrence of adverse events. Results: The median PFS was 24 months in the IDS plus dense HIPEC group, whereas it was 19 months in the IDS alone group (hazard ratio [HR] 0.46, 95% confidence interval [CI]: 0.33–0.65, p = 0.000). The median OS in patients treated with IDS plus dense HIPEC (51 months) was significantly longer than that in patients treated with IDS alone (40 months, HR 0.52, 95% CI: 0.35–0.78, p = 0.001). The demographic and preoperative clinical characteristics of these two groups were comparable (p > 0.05). In the IDS alone group, no adverse events were recorded in 42 (55.3%) of the 76 patients, and 14 (18.4%) patients were reported to have grade III/IV adverse events. In the IDS plus dense HIPEC group, no adverse events were recorded in 55 (45.5%) of the 121 patients, and 23 (19.0%) patients were reported to have grade III/IV adverse events. No postoperative deaths occurred within 30 days in either group and neither did severe fatal complications in the IDS plus dense HIPEC group. Conclusions: IDS plus dense HIPEC with cisplatin in Chinese patients with FIGO stage III serous EOC is associated with improved survival and is reasonably well tolerated by patients. Keywords: Dense hyperthermic intraperitoneal chemotherapy, Serous epithelial ovarian cancer, Survival, Interval debulking surgery * Correspondence: [email protected]; [email protected] †Xiaoli He and Li Wei contributed equally to this work. 1Department of Gynecology, Henan Provincial People’s Hospital, People’s Hospital of Zhengzhou University, People’s Hospital of Henan University, No.7, Weiwu Road, Jinshui District, Zhengzhou 450003, China Full list of author information is available at the end of the article © The Author(s). 2021 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data. He et al. BMC Cancer (2021) 21:738 Page 2 of 9 Background in China, and written informed consent was obtained Epithelial ovarian cancer (EOC) has the highest mortal- from each patient prior to all treatment procedures. All ity rate among all gynecological tumors worldwide, caus- patients in this study were diagnosed with FIGO stage ing nearly 22,500 deaths in China in 2015 and 14,335 III high-grade serous ovarian cancer, which based on deaths in the United States in 2018 [1, 2]. The most ef- surgical findings and histopathological results, between fective treatment for advanced EOC remains primary January 1, 2012 and April 31, 2017 at the Department of cytoreductive surgery (CRS) followed by intravenous Gynecology, Henan Provincial People’s Hospital. Staging chemotherapy with carboplatin and paclitaxel [3, 4]. In was done based on the 1988 International FIGO staging patients where complete primary cytoreduction is im- system between January 1, 2012 and December 31, 2012, possible, interval debulking surgery (IDS) can be per- the 2013 International FIGO staging system between formed after 2–4 cycles of neoadjuvant chemotherapy January 1, 2013 and December 31, 2013, and the 2014 (NACT) [5–7]. Peritoneum is the primary site of metas- International FIGO staging system between January 1, tasis of tumor cells from the ovary in advanced EOC pa- 2014 and April 31, 2017 [24]. The medical records of all tients [8, 9]. Therefore, intraperitoneal chemotherapy is patients were reviewed, and all patients were followed used to improve outcomes and minimize tumor dissem- up until March 31, 2020. ination and implantation [10, 11]. All patients who demonstrated an Eastern Cooperative Hyperthermic intraperitoneal chemotherapy (HIPEC) Oncology Group (ECOG) score 0–1[25, 26] in our is delivered under hyperthermic conditions and used to study underwent 2–4 cycles of NACT with a combin- increase chemotherapy penetration into peritoneal tu- ation of carboplatin (area under the curve of 5–6 mg per mors, including advanced EOC [12]. Randomized trials, milliliter per minute, AUC 5–6) and paclitaxel (175 mg meta-analyses, and retrospective studies have all shown per square meter of body-surface area, 175 mg/m2). that HIPEC is feasible and associated with prolonged After NACT, IDS was performed using peritonectomy. ovarian cancer survival rates [13–15]. Some studies have Complete cytoreductive surgery was defined as surgery demonstrated that despite the promise of HIPEC, HIPE that resulted in no visible disease (residual disease classi- C did not improve patient survival data compared with fication, R0), optimal cytoreductive surgery as surgery therapy without HIPEC [3, 14, 16]. Interestingly, in a that resulted in the presence of one or more residual tu- meta-analysis of patients with primary EOC, Huo et al. mors measuring ≤1 cm in diameter (R1), and incomplete showed that HIPEC combined with CRS was associated cytoreductive surgery as surgery that resulted in the with a significantly improved 2-, 3-, 4-, 5-, and 8-year presence of one or more residual lesions measuring > 1 OS compared with CRS alone [17]. cm in diameter (R2) [27]. In this study, regardless of In those studies, different drug and dose ranges of whether satisfactory tumor cell reduction is achieved HIPEC were used, which resulted in dissimilar survival after IDS (single or more residual lesions ≤1 cm), HIPEC times. In some studies, HIPEC was administered only was performed with the consent of patients and family after optimal cytoreductive surgery using cisplatin or a members. According to the patient’s request and a combination of doxorubicin, paclitaxel, or mitomycin C multidisciplinary discussion among general surgeons, gy- [8, 18–20]. In other studies, patients received HIPEC necologists, and physicians, patients were divided into with different doses of cisplatin [14, 21–23]. Numerous two groups: an IDS plus dense HIPEC group and an IDS investigations conducted to assess dose dense chemo- alone control group. therapy have shown clinical benefits. For instance, Ba M, et al. showed that HIPEC procedures with three sessions Inclusion and exclusion criteria were performed on the first, third, and fifth days after The inclusion criteria were as follows. (1) Patients aged CRS was comparable to other HIPEC procedures [22]. ≥18 years. (2) Patients that underwent pretreatment and Therefore, we referenced the procedure that have three preoperative evaluation with computed tomography sessions and defined them as Dense HIPEC with (CT) or magnetic resonance imaging (MRI), pelvic ultra- cisplatin. sound, and had tumor markers (including cancer antigen In this single-center study, we sought to retrospect- 125 [CA125] and human epididymis protein 4 [HE4]) as ively analyze the role of IDS combined with dense HIPE well as routine blood tests. (3) A pathologic diagnosis C with cisplatin in patients with primary FIGO stage III confirmed by ascites cytology or biopsy pathology. (4) serous EOC after NACT compared with IDS alone. Patients diagnosed with FIGO stage III serous EOC (high-grade serous ovarian cancer). (5) Patients with Methods normal blood counts, and adequate renal function. (6) Patients Patients with an ECOG performance status of 0–1. This retrospective study was approved by the Human The exclusion criteria were as follows. (1) Recurrent Ethics Committee of Henan Provincial People’s Hospital peritoneal ovarian cancer patients. (2) Patients with He et al. BMC Cancer (2021) 21:738 Page 3 of 9 previous primary cytoreductive surgery. (3) Patients with Study variables the presence of extra-abdominal metastasis. (4) Patients The following information was reviewed and collected. that treated with bevacizumab or poly ADP-ribose poly- Patient demographics, medical history, tumor markers, merase inhibitors. (5) Patients that with poor general pathologic characteristics, chemotherapy regime includ- health, renal insufficiency, heart failure, or the existence ing the dose, surgical procedures, tumor debulking sta- of a lesion in the central nervous system. tus according to the visible residual disease classification [28], the pre- and post-HIPEC lab values (absolute neu- trophil count, platelets, hematocrit, and hemoglobin), IDS plus dense HIPEC group and HIPEC techniques and drugs, patient adverse events, After the IDS procedure, dense HIPEC was administered length of hospital stay, and the cost of hospital data.
Load more

Recommended publications
  • Quantitative Evaluation for the Threat Degree of a Thermal Reservoir to Deep Coal Mining
    Hindawi Geofluids Volume 2020, Article ID 8885633, 15 pages https://doi.org/10.1155/2020/8885633 Research Article Quantitative Evaluation for the Threat Degree of a Thermal Reservoir to Deep Coal Mining Yun Chen ,1 Xinyi Wang ,1,2,3 Yanqi Zhao ,1 Haolin Shi ,1 Xiaoman Liu ,1 and Zhigang Niu 4 1School of Resource and Environment, Henan Polytechnic University, Jiaozuo 454000, China 2Collaborative Innovation Center of Coalbed Methane and Shale Gas for Central Plains Economic Region of Henan Province, Jiaozuo 454000, China 3State Collaborative Innovation Center of Coal Work Safety and Clean-Efficiency Utilization, Jiaozuo 454000, China 4Henan Provincial Coal Geological Survey and Research Institute, Zhengzhou 450052, China Correspondence should be addressed to Xinyi Wang; [email protected] and Yanqi Zhao; [email protected] Received 25 May 2020; Revised 7 September 2020; Accepted 19 October 2020; Published 9 November 2020 Academic Editor: Hualei Zhang Copyright © 2020 Yun Chen et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Taking the Suiqi coalfield located in North China as the object, where the coal seam burial depth is more than 1100 m, the water abundance of the roof pore thermal storage aquifer is better than average, the ground temperature is abnormally high, and hydrogeological data are relatively lacking, this paper selects and determines eight index factors that influence the mining of the coalfield. Based on the analytic hierarchy process (AHP), the index factor weight is defined, and then, the threat degree of the roof thermal storage aquifer to the coal mining is quantitatively evaluated and divided by using the fuzzy variable set theory.
    [Show full text]
  • Directors, Supervisors and Senior Management
    THIS DOCUMENT IS IN DRAFT FORM, INCOMPLETE AND SUBJECT TO CHANGE AND THE INFORMATION MUST BE READ IN CONJUNCTION WITH THE SECTION HEADED “WARNING” ON THE COVER OF THIS DOCUMENT. DIRECTORS, SUPERVISORS AND SENIOR MANAGEMENT BOARD OF DIRECTORS App1A-41(1) The Board consists of eleven Directors, including five executive Directors, two non-executive 3rd Sch 6 Directors and four independent non-executive Directors. The Directors are elected for a term of three years and are subject to re-election, provided that the cumulative term of an independent non-executive Director shall not exceed six years pursuant to the relevant PRC laws and regulations. The following table sets forth certain information regarding the Directors. Time of Time of joining the joining the Thirteen Date of Position held Leading City Time of appointment as of the Latest Group Commercial joining the as a Practicable Name Age Office Banks Bank Director Date Responsibility Mr. DOU 54 December N/A December December Executive Responsible for the Rongxing 2013 2014 23, 2014 Director, overall management, (竇榮興) chairperson of strategic planning and the Board business development of the Bank Ms. HU 59 N/A January 2010 December December Executive In charge of the audit Xiangyun (Joined 2014 23, 2014 Director, vice department, regional (胡相雲) Xinyang chairperson of audit department I and Bank) the Board regional audit department II of the Bank Mr. WANG Jiong 49 N/A N/A December December Executive Responsible for the (王炯) 2014 23, 2014 Director, daily operation and president management and in charge of the strategic development department and the planning and financing department of the Bank Mr.
    [Show full text]
  • Table of Codes for Each Court of Each Level
    Table of Codes for Each Court of Each Level Corresponding Type Chinese Court Region Court Name Administrative Name Code Code Area Supreme People’s Court 最高人民法院 最高法 Higher People's Court of 北京市高级人民 Beijing 京 110000 1 Beijing Municipality 法院 Municipality No. 1 Intermediate People's 北京市第一中级 京 01 2 Court of Beijing Municipality 人民法院 Shijingshan Shijingshan District People’s 北京市石景山区 京 0107 110107 District of Beijing 1 Court of Beijing Municipality 人民法院 Municipality Haidian District of Haidian District People’s 北京市海淀区人 京 0108 110108 Beijing 1 Court of Beijing Municipality 民法院 Municipality Mentougou Mentougou District People’s 北京市门头沟区 京 0109 110109 District of Beijing 1 Court of Beijing Municipality 人民法院 Municipality Changping Changping District People’s 北京市昌平区人 京 0114 110114 District of Beijing 1 Court of Beijing Municipality 民法院 Municipality Yanqing County People’s 延庆县人民法院 京 0229 110229 Yanqing County 1 Court No. 2 Intermediate People's 北京市第二中级 京 02 2 Court of Beijing Municipality 人民法院 Dongcheng Dongcheng District People’s 北京市东城区人 京 0101 110101 District of Beijing 1 Court of Beijing Municipality 民法院 Municipality Xicheng District Xicheng District People’s 北京市西城区人 京 0102 110102 of Beijing 1 Court of Beijing Municipality 民法院 Municipality Fengtai District of Fengtai District People’s 北京市丰台区人 京 0106 110106 Beijing 1 Court of Beijing Municipality 民法院 Municipality 1 Fangshan District Fangshan District People’s 北京市房山区人 京 0111 110111 of Beijing 1 Court of Beijing Municipality 民法院 Municipality Daxing District of Daxing District People’s 北京市大兴区人 京 0115
    [Show full text]
  • Expressions of PCNA, P53, P21waf-1 and Cell
    P.O.Box 2345, Beijing 100023,China World J Gastroenterol 2003;9(7):1601-1603 Fax: +86-10-85381893 World Journal of Gastroenterology E-mail: [email protected] www.wjgnet.com Copyright © 2003 by The WJG Press ISSN 1007-9327 • BRIEF REPORTS • Expressions of PCNA, p53, p21WAF-1 and cell proliferation in fetal esophageal epithelia: Comparative study with adult esophageal lesions from subjects at high-incidence area for esophageal cancer in Henan, North China Ying Xing, Yu Ning, Li-Qiang Ru, Li-Dong Wang Ying Xing, Li-Qiang Ru, Department of Neurobiology, Tongji Xing Y, Ning Y, Ru LQ, Wang LD. Expressions of PCNA, p53, Medical College, Huazhong University of Science and Technology, p21WAF-1 and cell proliferation in fetal esophageal epithelia: Wuhan, 430030, Hubei Province, China Comparative study with adult esophageal lesions from subjects Yu Ning, Department of Physiology, College of Medicine, Zhengzhou at high-incidence area for esophageal cancer in Henan, North University, Zhengzhou, 450052, Henan Province, China China. World J Gastroenterol 2003; 9(7): 1601-1603 Li-Dong Wang, Laboratory for Cancer Research, College of Medicine, http://www.wjgnet.com/1007-9327/9/1601.asp Zhengzhou University, Zhengzhou, 450052, Henan Province, China Supported by National Distinguished Young Scientist Foundation of China, No.30025016 Correspondence to: Dr. Li-Dong Wang, Professor of Pathology and INTRODUCTION Oncology and Ying Xing, Professor of Physiology, Laboratory for Cancer Research, College of Medicine, Zhengzhou University, Fetal esophageal epithelium is characterized by cellular Zhengzhou 450052, Henan Province, China. [email protected] hyperproliferation. Tumor suppressor genes have been known Telephone: +86-371-6970165 Fax: +86-371-6970165 to suppress malignant cell proliferation through encoding Received: 2003-03-02 Accepted: 2003-03-25 corresponding proteins that inhibit cell cycle.
    [Show full text]
  • Flood Adaptive Landscapes in the Yellow River Basin of China
    Journal of Landscape Architecture ISSN: 1862-6033 (Print) 2164-604X (Online) Journal homepage: http://www.tandfonline.com/loi/rjla20 Living with Water: Flood Adaptive Landscapes in the Yellow River Basin of China Kongjian Yu , Zhang Lei & Li Dihua To cite this article: Kongjian Yu , Zhang Lei & Li Dihua (2008) Living with Water: Flood Adaptive Landscapes in the Yellow River Basin of China, Journal of Landscape Architecture, 3:2, 6-17, DOI: 10.1080/18626033.2008.9723400 To link to this article: https://doi.org/10.1080/18626033.2008.9723400 Published online: 01 Feb 2012. Submit your article to this journal Article views: 364 View related articles Citing articles: 3 View citing articles Full Terms & Conditions of access and use can be found at http://www.tandfonline.com/action/journalInformation?journalCode=rjla20 living with Water: Flood adaptive landscapes in the yellow river Basin of China Kongjian Yu, Zhang Lei, Li Dihua the graduate school of landscape architecture, Peking University Abstract Introduction This paper is a report on a research project. It shows how the past expe- Global warming and climate change may increase flood hazards in some rience of adaptive strategies that have evolved in the long history of sur- regions and drought in others. While reducing greenhouse gas emissions vival under hazardous conditions is inspiring for us in facing future un- is a priority, it is of no less significance to develop adaptive strategies to certainty. Based on a study of several ancient cities in the Yellow River lessen the potential hazards caused by climate change. The past experience floodplain, this paper discusses the disastrous experience of floods and of adaptive strategies evolved in the long history of survival under hazard- waterlogging and finds three major adaptive landscape strategies: siting ous conditions is inspiring for us in facing future uncertainty.
    [Show full text]
  • United States Bankruptcy Court Northern District of Illinois Eastern Division
    Case 12-27488 Doc 49 Filed 07/27/12 Entered 07/27/12 13:10:45 Desc Main Document Page 1 of 343 UNITED STATES BANKRUPTCY COURT NORTHERN DISTRICT OF ILLINOIS EASTERN DIVISION In re: ) Chapter 7 ) PEREGRINE FINANCIAL GROUP, INC., ) Case No. 12-27488 ) ) ) Honorable Judge Carol A. Doyle Debtor. ) ) Hearing Date: August 9, 2012 ) Hearing Time: 10:00 a.m. NOTICE OF MOTION TO: See Attached PLEASE TAKE NOTICE that on August 9, 2012 at 10:00 a.m., the undersigned shall appear before the Honorable Carol A. Doyle, United States Bankruptcy Judge for the United States Bankruptcy Court, Northern District of Illinois, Eastern Division, in Courtroom 742 of the Dirksen Federal Building, 219 South Dearborn Street, Chicago, Illinois 60604, and then and there present the TRUSTEE’S MOTION FOR ORDER APPROVING PROCEDURES FOR FIXING PRICING AND CLAIM AMOUNTS IN CONNECTION WITH THE TERMINATION AND LIQUIDATION OF FOREIGN EXCHANGE CUSTOMER AGREEMENTS (the “Motion”). PLEASE TAKE FURTHER NOTICE that if you are a foreign exchange customer of Peregrine Financial Group, Inc. or otherwise received this Notice, your rights may be affected by the Motion. PLEASE TAKE FURTHER NOTICE that a copy of the Motion is available on the Trustee’s website, www.PFGChapter7.com, or upon request sent to [email protected]. Respectfully submitted, Ira Bodenstein, not personally, but as chapter 7 trustee for the estate of Peregrine Financial Group, Inc. Dated: July 27, 2012 By: /s/ John Guzzardo One of his proposed attorneys Robert M. Fishman (#3124316) Salvatore Barbatano (#0109681) John Guzzardo (#6283016) Shaw Gussis Fishman Glantz {10403-001 NOM A0323583.DOC}4841-1459-7392.2 Case 12-27488 Doc 49 Filed 07/27/12 Entered 07/27/12 13:10:45 Desc Main Document Page 2 of 343 Wolfson & Towbin LLC 321 North Clark Street, Suite 800 Chicago, IL 60654 Phone: (877) 465-1849 [email protected] Proposed Counsel to the Trustee and Geoffrey S.
    [Show full text]
  • Annual Results Announcement for the Year Ended 31 December 2018 Financial Highlights
    Hong Kong Exchanges and Clearing Limited and The Stock Exchange of Hong Kong Limited take no responsibility for the contents of this announcement, make no representation as to its accuracy or completeness and expressly disclaim any liability whatsoever for any loss howsoever arising from or in reliance upon the whole or any part of the contents of this announcement. (Stock Code: 0832) ANNUAL RESULTS ANNOUNCEMENT FOR THE YEAR ENDED 31 DECEMBER 2018 FINANCIAL HIGHLIGHTS • Revenue for the year ended 31 December 2018 amounted to approximately RMB14,783 million, representing an increase of approximately 6.5% compared with the year 2017. • Gross profit margin for the year was 34.4%, representing an increase of 10.8 percentage points as compared with 2017. • Profit attributable to equity shareholders of the Company for the year amounted to approximately RMB1,154 million, representing an increase of approximately 42.3% compared with the year 2017. • Net profit margin for the year was 9.6%, representing an increase of 3.1 percentage points as compared with 2017. • Basic earnings per share for the year was RMB44.30 cents, an increase of approximately 33.5% compared with the year 2017. • The Board recommended to declare a final dividend of HK$14.12 cents (approximately RMB12.09 cents) per share. 1 ANNUAL RESULTS The Board announces the consolidated results (the “Annual Results”) of the Group for the year ended 31 December 2018 with comparative figures for the preceding financial year, as follows: CONSOLIDATED INCOME STATEMENT for the year ended 31
    [Show full text]
  • Resettlement Planning Report of Henan Towns Water (Supply and Draiage) Project
    Resettlement Planning Report of Henan Towns Water (Supply and Draiage) Project * Project by the Loan of the World Bank RP386 VOL. 1 Public Disclosure Authorized Resettlement Planning Report Public Disclosure Authorized of Henan Towns Water (Supply and Drainage) Project the Peoples'Republic of China Public Disclosure Authorized The Foreign-loan Project Management Office of Henan Public Disclosure Authorized Zhengzhou Oct. 2005 *~~~~~ I Resettlement Planning Report of Henan Towns Water (Supply and Draiage) Project Contents Preface ....................................................... 1 Definition of Special Terms ....................................................... 3 1. Brief introduction on Henan Towns Water (Supply and Drainage) Project ........................ 5 1.1 General state of the Project ....................................................... 5 1.1.1 Background ....................................................... 5 1.1.2 The guiding ideology ....................................................... 6 1.1.3 The overall objective ................... : .6 1.1.4 The basis of the Project .................... 6 2. General social and economic condition of affected areas .......................................... 21 2 E 1 Natural, climate and water resource conditions .......................................... 21 _ 2.1.1 Climate ........ 21 2.1.2 water resources & water system ............................................... 21 2.2. Social and economic situation of project areas .................................... 22 2.2.1. General
    [Show full text]
  • CCRE Secures 68Th to 75Th Management Entrustment Contracts with Light-Asset Model Projects in Shangqiu, Sanmenxia, Zhumadian, Zhoukou, Puyang and Xinxiang
    [For immediate release] CCRE Secures 68th to 75th Management Entrustment Contracts with Light-Asset Model Projects in Shangqiu, Sanmenxia, Zhumadian, Zhoukou, Puyang and Xinxiang (22 Jan 2018– Hong Kong) –– Central China Real Estate Limited ("CCRE" or the "Company", together with its subsidiaries, the "Group"; SEHK stock code: 832), one of the leading Henan- based property developers announces that on 6 December, 20 December, 26 December and 29 December 2017 seperately, Henan Zhongyuan Central China City Development Limited ("CCRE Zhongyuan"), an indirect wholly-owned subsidiary of the Company, entered into management entrustment contracts for developing real estate projects with Sui County Zhonghe Properties Limited ("Sui County Zhonghe"), Lushi Lingchuang Properties Limited ("Lushi Lingchuang"), Queshan County Jianda Properties Limited ("Queshan Jianda"), Xihua County Zhiteng Properties Limited ("Xihua Zhiteng"), Henan Xinbaoli Properties Limited ("Henan Xinbaoli"), Qingfeng Jianhong City Development Limited ("Qingfeng Jianhong"), Yanjin Jiancheng Properties Limited ("Yanjin Jiancheng") and Shangqiu City Jiantai Properties Limited ("Shangqiu Jiantai"). On 6 December, CCRE Zhongyuan (as trustee) entered into its 68th management entrustment contract for a real estate project with a planned gross floor area of approximately 122,000 square meters with Li Jingsheng*(李景生) and Zhang Guoyin*(張國印) (as guarantors) and Sui County Zhonghe (as principal) for a period of 36 months (the "Sui County Honghe Road Project Management Entrustment Contract").
    [Show full text]
  • China – CHN40285 –Christians in Henan and Zhengzhou 26 April 2012
    Country Advice China China – CHN40285 –Christians in Henan and Zhengzhou 26 April 2012 1. Please provide information on the current treatment by authorities of Christians in Henan Province, and if available, specifically about Zhengzhou City. Overview of Christians in Henan Province Henan, the second most populous province in China, is one of the great centres of Protestant Christianity in China. One estimate put the number of Christians in the province in 2001 at almost 10 million, or 10.4% of the province, with the majority belonging to unregistered house churches,1 and even government sources placed the number at up to 5 million in 1998.2 Henan is characterised by the presence of several strong house-church networks and a number of schismatic groups and sects, and has seen a high level of conflict between Christians and the authorities in some areas. Tony Lambert gives this profile of the province in his 2006 China’s Christian Millions: Henan is a centre of Christian revival and powerhouse of evangelism. The unregistered house church movement is very strong in this province, but so, sadly, are a number of sects and cults. Henan has seen astronomic church growth since the Cultural Revolution. In 1949 there were about 100,000 Protestants. On the eve of the Cultural Revolution in 1965 that number had decreased to 78,000. However, in 1990 a local government handbook estimated the number of Christians had risen to 800,000! In 1996 TSPM sources in Henan estimated the church had grown to a staggering 3.5 million of whom only 1.5 million had been formally baptised – the remaining 2 million were classified as ―seekers‖.
    [Show full text]
  • Directors, Supervisors and Senior Management
    THIS DOCUMENT IS IN DRAFT FORM, INCOMPLETE AND SUBJECT TO CHANGE AND THE INFORMATION MUST BE READ IN CONJUNCTION WITH THE SECTION HEADED “WARNING” ON THE COVER OF THIS DOCUMENT. DIRECTORS, SUPERVISORS AND SENIOR MANAGEMENT BOARD OF DIRECTORS App1A-41(1) Our Board consists of eleven Directors, including five executive Directors, two non-executive 3rd Sch 6 Directors and four independent non-executive Directors. Our Directors are elected for a term of three years and are subject to re-election, provided that the cumulative term of an independent non-executive Director shall not exceed six years pursuant to the relevant PRC laws and regulations. The following table sets forth certain information regarding our Directors. Time of Time of joining the joining the Thirteen Date of Position held Leading City Time of appointment as of the Latest Group Commercial joining the as a Practicable Name Age Office Banks Bank Director Date Responsibility Mr. DOU 54 December N/A December December Executive Responsible for the Rongxing 2013 2014 23, 2014 Director, overall (竇榮興) chairperson of management, the Board strategic planning and business development of the Bank Ms. HU 59 N/A January 2010 December December Executive In charge of the Xiangyun (Joined 2014 23, 2014 Director, vice audit department, (胡相雲) Xinyang chairperson of regional audit Bank) the Board department I and regional audit department II of the Bank Mr. WANG Jiong 48 N/A N/A December December Executive Responsible for the (王炯) 2014 23, 2014 Director, daily operation and president management and in charge of the strategic development department and the planning and financing department of the Bank Mr.
    [Show full text]
  • A12 List of China's City Gas Franchising Zones
    附录 A12: 中国城市管道燃气特许经营区收录名单 Appendix A03: List of China's City Gas Franchising Zones • 1 Appendix A12: List of China's City Gas Franchising Zones 附录 A12：中国城市管道燃气特许经营区收录名单 No. of Projects / 项目数：3,404 Statistics Update Date / 统计截止时间：2017.9 Source / 来源：http://www.chinagasmap.com Natural gas project investment in China was relatively simple and easy just 10 CNG）、控股投资者（上级管理机构）和一线运营单位的当前主官经理、公司企业 years ago because of the brand new downstream market. It differs a lot since 所有制类型和联系方式。 then: LNG plants enjoyed seller market before, while a LNG plant investor today will find himself soon fighting with over 300 LNG plants for buyers; West East 这套名录的作用 Gas Pipeline 1 enjoyed virgin markets alongside its paving route in 2002, while today's Xin-Zhe-Yue Pipeline Network investor has to plan its route within territory 1. 在基础数据收集验证层面为您的专业信息团队节省 2,500 小时之工作量； of a couple of competing pipelines; In the past, city gas investors could choose to 2. 使城市燃气项目投资者了解当前特许区域最新分布、其他燃气公司的控股势力范 sign golden areas with best sales potential and easy access to PNG supply, while 围；结合中国 LNG 项目名录和中国 CNG 项目名录时，投资者更易于选择新项 today's investors have to turn their sights to areas where sales potential is limited 目区域或谋划收购对象； ...Obviously, today's investors have to consider more to ensure right decision 3. 使 LNG 和 LNG 生产商掌握采购商的最新布局，提前为充分市场竞争做准备； making in a much complicated gas market. China Natural Gas Map's associated 4. 便于 L/CNG 加气站投资者了解市场进入壁垒，并在此基础上谨慎规划选址； project directories provide readers a fundamental analysis tool to make their 5. 结合中国天然气管道名录时，长输管线项目的投资者可根据竞争性供气管道当前 decisions. With a completed idea about venders, buyers and competitive projects, 格局和下游用户的分布，对管道路线和分输口建立初步规划框架。 analyst would be able to shape a better market model when planning a new investment or marketing program.
    [Show full text]