Contents GUT Volume 52 Number 1 January 2003

contents GUT Volume 52 Number 1 January 2003

Journal of the British Society of Gastroenterology, a registered charity ......

AIMS AND SCOPE Leading article Gut publishes high quality original papers on all aspects of 1 Is intestinal metaplasia of the stomach gastroenterology and hepatology as well as topical, authoritative editorials, comprehensive reviews, case reports, reversible? M M Walker Gut: first published as on 1 January 2003. Downloaded from therapy updates and other articles of interest to ...... gastroenterologists and hepatologists. Commentaries EDITOR Professor Robin C Spiller 5s,M,L,XL...T Wang, G Triadafilopoulos 7 HLA-DQ8 as an Ir gene in coeliac disease SPECIAL SECTIONS EDITOR Ian Forgacs K E A Lundin 8 A rat virus visits the clinic: translating basic ASSOCIATE EDITORS discoveries into clinical medicine in the 21st David H Adams Immunofluorescence John C Atherton century C R Boland, A Goel staining of jejunal Ray J Playford ...... Jürgen Scholmerich mucosa from a DQ8+ Jan Tack Clinical @lert AlastairJMWatson coeliac patient. (From the paper by Mazzarella 10 Dyspepsia management in the millennium: to EVIDENCE BASED GASTROENTEROLOGY et al, pp 57–62). test and treat or not? B C Delaney ADVISORY GROUP Richard F A Logan ...... StephenJWEvans Science @lert Andrew Hart Jane Metcalf 12 RUNX 3, apoptosis 0: a new gastric tumour EDITORIAL OFFICE MANAGER suppressor S F Moss Claire Castle ......

EDITORIAL ASSISTANTS Debate Alex Hodge 14 Protagonist: Ablative mucosectomy is the Sarah Taylor procedure of choice to prevent Barrett’s cancer

TECHNICAL EDITORS H Barr http://gut.bmj.com/ Linda Gough Josie Stephenson 16 Antagonist: Ablative mucosectomy is the procedure of choice to prevent Barrett’s cancer EDITORIAL BOARD Seep24 R C Fitzgerald I Bjarnason - UK M F Neurath - USA ...... G E Boeckxstaens - Netherlands MNovelli-UK L Bueno-France D Schuppan - Germany Oesophageal disease A M Di Bisceglie – USA F Shanahan - Ireland H J Cooke - USA N A Shepherd - UK 18 Biopsy surveillance is still necessary in patients E El-Omar - UK R C Spiller - UK on September 29, 2021 by guest. Protected copyright. S L Friedman - USA with Barrett’s oesophagus despite new J J Y Sung - Hong Kong L Greco - Italy endoscopic imaging techniques K Egger, G Tougas - Canada RJones-UK G Triadaﬁlopoulos - USA M Werner, A Meining, R Ott, H-D Allescher, MAKamm-UK H Höfler, M Classen, T Rösch E J Kuipers - Netherlands Z Tulassay - Hungary G W McCaughan - Australia SJHVanDeventer - K E L McColl - UK Netherlands C24 Magnification chromoendoscopy for the H R Mertz - USA S J W Evans (Statistical Adviser) detection of intestinal metaplasia and K Moore - UK Editor, British Medical Journal dysplasia in Barrett’s oesophagus P Sharma, A P Weston, M Topalovski, R Cherian, LOCAL EDITIONS A Bhattacharyya, R E Sampliner China Netherlands/Belgium 28 Time gated fluorescence spectroscopy in Excerpta Medica Asis Ltd Medicom Exvcel 19/F Eight Commercial Tower Box 151 Barrett’s oesophagus M-A E J Ortner, B Ebert, 8 Sun Yip Street 1400 AD Bussum E Hein, K Zumbusch, D Nolte, U Sukowski, Chai Wang Netherlands J Weber-Eibel, B Fleige, M Dietel, M Stolte, Hong Kong Telephone: +31 35 69 52480 Telephone: +852 2965 1300 G Oberhuber, R Porschen, B Klump, Fax: +31 35 69 48565 Fax: +852 2976 0778 H Hörtnagl, H Lochs, H Rinneberg 34 Endocinch therapy for gastro-oesophageal COPYRIGHT reflux disease: a one year prospective follow © 2003 BMJ Publishing Group & British Society of up Z Mahmood, B P McMahon, Q Arfin, Gastroenterology. All rights reserved; no part of this publication may be reproduced, stored in a retrieval system, or transmitted in P J Byrne, J V Reynolds, E M Murphy, D G Weir any form or by any means, electronic, mechanical, photocopying, ...... recording, or otherwise without the prior permission of Gut. Helicobacter pylori Authors are required to grant Gut an exclusive licence to publish 40 Treatment of Helicobacter pylori in functional Print ISSN 0017 5749 Online ISSN 1468 3288 dyspepsia resistant to conventional Publication: Monthly (subscribers also receive all supplements) management: a double blind randomised trial with a six month follow up H R Koelz, INSTRUCTIONS TO AUTHORS R Arnold, M Stolte, M Fischer, A L Blum, the Full instructions are available online at www.gutjnl.com/misc/ FROSCH Study Group ifora.shtml If you do not have web access please contact the editorial ofﬁce ...... Gut is published by BMJ Publishing Group and printed in the Small intestine UK on acid free paper by Cambrian Printers, Aberystwyth www.publicationethics.org.uk 47 Avenin fails to induce a Th1 response in coeliac Periodicals postage paid, Rahway, NJ. Postmaster: send address This journal is a member of and changes to: Gut, c/o Mercury Airfreight International Ltd, 365 subscribes to the principles of the tissue following in vitro culture C Kilmartin, Blair Road, Avenel, NJ 07001, USA Committee on Publication Ethics S Lynch, M Abuzakouk, H Wieser, C Feighery contents GUT Volume 52 Number 1 January 2003

...... 53 Tachykinins potently stimulate human small bowel blood flow: a laser Doppler Biliary disease flowmetry study in humans P T Schmidt, 109 Gall bladder dysmotility: a risk factor for M Lördal, B Gazelius, P M Hellström gall stone formation in Gut: first published as on 1 January 2003. Downloaded from C57 An immunodominant DQ8 restricted hypertriglyceridaemia and reversal on gliadin peptide activates small intestinal triglyceride lowering therapy by immune response in in vitro cultured bezafibrate and fish oil IJAMJonkers, mucosa from HLA-DQ8 positive but not A H M Smelt, M Ledeboer, M E Hollum, Seep57 HLA-DQ8 negative coeliac patients I Biemond, F Kuipers, F Stellaard, G Mazzarella, M Maglio, F Paparo, R Boverhof, A E Meinders, G Nardone, R Stefanile, L Greco, CHBWLamers,AAMMasclee Y van de Wal, Y Kooy, F Koning, S Auricchio, R Troncone 116 Risk factors for recurrent bile duct stones after endoscopic papillotomy T Ando, ...... T Tsuyuguchi, T Okugawa, M Saito, Therapy update T Ishihara, T Yamaguchi, H Saisho 63 Osteoporosis in inflammatory bowel ...... disease J Compston Liver disease ...... 122 Different hepatitis B virus core gene Inﬂammatory bowel disease mutations in children with chronic 65 Increased expression of interleukin 17 in infection and hepatocellular carcinoma inflammatory bowel disease S Fujino, Y-H Ni, M-H Chang, H-Y Hsu, D-J Tsuei A Andoh, S Bamba, A Ogawa, K Hata, 126 Impact of smoking on histological liver Y Araki, T Bamba, Y Fujiyama lesions in chronic hepatitis C C Hézode, 71 CARD4/NOD1 is not involved in I Lonjon, F Roudot-Thoraval, J-P Mavier, inflammatory bowel disease H Zouali, J-M Pawlotsky, E S Zafrani, D Dhumeaux Seep65 S Lesage, F Merlin, J-P Cézard and the 130 Acute propranolol administration EPWG-IBD group, J-F Colombel and the effectively decreases portal pressure in EPIMAD group, J Belaiche and the GETAID http://gut.bmj.com/ patients with TIPS dysfunction L Bellis, group, S Almer, C Tysk, C O’Morain, E Moitinho, J G Abraldes, M Graupera, M Gassull, S Christensen, Y Finkel, J C García-Pagán, J Rodés, J Bosch R Modigliani, C Gower-Rousseau, J Macry, M Chamaillard, G Thomas, J-P Hugot 134 MELD scoring system is useful for predicting prognosis in patients with 75 Association between K469E allele of liver cirrhosis and is correlated with intercellular adhesion molecule 1 gene and residual liver function: a European study inflammatory bowel disease in a Japanese on September 29, 2021 by guest. Protected copyright. population J Matsuzawa, K Sugimura, F Botta, E Giannini, P Romagnoli, Y Matsuda, M Takazoe, K Ishizuka, A Fasoli, F Malfatti, B Chiarbonello, T Mochizuki, S S Seki, O Yoneyama, E Testa, D Risso, G Colla, R Testa H Bannnai, K Suzuki, T Honma, H Asakura ...... 79 Induction of experimental ulcerative colitis Case report by Fusobacterium varium isolated from 140 Safe treatment of thiopurine colonic mucosa of patients with ulcerative S-methyltransferase deficient Crohn’s colitis T Ohkusa, I Okayasu, T Ogihara, disease patients with azathioprine K Morita, M Ogawa, N Sato B A Kaskas, E Louis, U Hindorf, 84 Changes in chemical coding of myenteric E Schaeffeler, J Deflandre, F Graepler, neurones in ulcerative colitis M Neunlist, K Schmiegelow, M Gregor, 100 A P Aubert, C Toquet, T Oreshkova, J Barouk, U M Zanger, M Eichelbaum, M Schwab 90 P A Lehur, M Schemann, J P Galmiche ...... 80 70 91 Interleukin 10 genotypes in irritable bowel Gut ﬁle 60 syndrome: evidence for an inflammatory 50 143 Elemental diet in the treatment of 40 component? W M Gonsalkorale, C Perrey, Apoptosis (%) 30 V Pravica,PJWhorwell, I V Hutchinson orofacial Crohn’s disease 20 E A B Cameron, S J Middleton, 10 ...... 0 ...... 0 6 12 16 20 24 48 72 Cancer Time (h) Review Control Butyrate 20 mM 94 Butyrate induced Caco-2 cell apoptosis is B mediated via the mitochondrial pathway 144 Mitogen activated protein (MAP) kinase F M Ruemmele, S Schwartz, E G Seidman, signal transduction pathways and novel S Dionne, E Levy, M J Lentze anti-inflammatory targets D W Hommes, M P Peppelenbosch,SJHvanDeventer C C101 A prospective study of circulating mutant ...... KRAS2 in the serum of patients with colorectal neoplasia: strong prognostic PostScript indicator in postoperative follow up 152 Letters B M Ryan, F Lefort, R McManus, J Daly, Seep94 P W N Keeling,DGWeir, D Kelleher 156 Book reviews Correction Notices