Supplemental Methods

Kidney Retrieval and Transplantation

Porcine retrieval and heterotopic autotransplantation was performed as previously

described elsewhere by our laboratory.1 In brief, animals were given intramuscular injections of

ketamine (20mg/kg; Bimeda-MTC Animal Health Inc., Cambridge, Canada), midazolam

(0.3mg/kg; Pharmaceutical Partners of Canada Inc, Richmond Hill, Canada), and atropine

(0.04mg/kg; Rafter 8 Products, Calgary, Canada) for anestheisa. Isoflurane (1.5%;

Pharmaceutical Partners of Canada Inc; Richmond Hill, Canada) was administered after

intubation. Sterile technique with a midline incision was used to dissect the right kidney. Heparin

(2,000 IU; Sandoz Canada Inc., Toronto, Canada) was administered intravenous (IV) 2 min prior

to inducing 30min WI through vascular clamping. Following resection, grafts were immediately

flushed with 300mL of --ketoglutarate (HTK) solution (Metapharm Inc.,

Brantford, Canada) at 4oC prior to placement on NEVKP circuit or cold storage. During storage,

pigs recovered from anesthesia after the abdomen was closed.

Pigs were re-anesthestized before transplantation with 5mL Propofol IV (PharmaScience

Inc., Montreal, Canada). A 150mg/h continuous infusion of Propofol IV was given with 1.5%

isofluorane after intubation. A contralateral nephrectomy was performed and this kidney was

discarded. The stored kidney was then flushed with 300mL of HTK solution prior to performing

the following renal anastomoses: renal vein end-to-side to vena cava, renal artery end-to-side to aorta, and donor ureter side-to-side to recipient ureter. Perioperative care, drug administration, serum sample collection, 24h urine collection, and follow-up were performed as previously described by our group.1

Normothermic Ex Vivo Kidney Perfusion. We reported our group’s Normothermic Ex-Vivo Kidney Perfusion previously2,3. In short, kidneys were perfused for 8 hours in a circuit consisting of a neonatal cardiopulmonary bypass, a S3 heart- machine and a centrifugal pump in continuous flow (Sorin Group Inc.,

Markham, Canada). A custom-made double walled organ chamber was used to house the kidney and to maintain sterility and normothermic temperatures.

The perfusate was created to represent near physiological conditions. This consisted of

Ringer’s lactate, Steen solution (XVIVO Perfusion AB, Goteborg, Sweden), washed erythrocytes, double reverse osomosis water, sodium bicarbonate (8.4%), calcium gluconate

(10%, 100mg/mL), and heparin. Verapamil at a continues flow rate of 0.25mg/h was provided to the arterial portion of the circuit and a continuous infusion of amino acids, glucose, and insulin

(Dextrose+Travasol+Humulin R, 1mL/h) was added to the venous reservoir and titrated to achieve a target glucose concentration of 5-15mmol/L. Oxygen and carbon dioxide gas

(95%/5%; 2L/min) was also administered continuously. Through the course of perfusion, additional Ringer’s lactate (10mL/h) was provided to replace urine and other insensible losses from the circuit.

Static Cold Storage

Following retrieval and cold flush described above, the donor kidney was placed in a sterile organ bag (CardioMed Supplies Inc., Lindsay, Canada) containing cold HTK solution, stored around ice to maintain temperatures at 4oC and stored for 8 hours.

No Storage Control Group

The no storage (NS) control animals were described before by our group4. Kidney

retrieval and induction of WI were performed as above. Grafts were flushed with 300mL of HTK

following retrieval and grafts were immediately re-transplanted as above without any additional storage time. Animals were only recovered from anaesthesia following completion of

transplantation.

Additional Statistical Analysis

Unless otherwise specified, significance was defined as p<0.05 between NEVKP and

SCS groups. For multiple comparisons, one-way analysis of variance (ANOVA) was used with

Tukey’s post-hoc test to identify significant differences between >2 groups.

1. Kaths, J.M., et al. Heterotopic Renal Autotransplantation in a Porcine Model: A Step-by-Step Protocol. J Vis Exp, 53765 (2016). 2. Kaths, J.M., et al. Normothermic Ex Vivo Kidney Perfusion for the Preservation of Kidney Grafts prior to Transplantation. J Vis Exp, e52909 (2015). 3. Kaths, J.M., et al. Continuous Normothermic Ex Vivo Kidney Perfusion Improves Graft Function in Donation After Circulatory Death Pig Kidney Transplantation. Transplantation 101, 754-763 (2017). 4. Hamar, M., et al. Normothermic Ex Vivo Kidney Perfusion Reduces Warm Ischemic Injury of Porcine Kidney Grafts Retrieved After Circulatory Death. Transplantation 102, 1262-1270 (2018).

50 14 * * 1200 45 12 * * 1000 40 10 35 800 8 30 * 600 6 * 25 400 20 4 * 15 Serum (mg/dL)Serum Creatinine * 200 (µmol/L) Serum Creatinine 2 10 0 0 5 1 2 3 4 5 6 7 8

Creatinine Clearance (ml/min) Clearance Creatinine 0 Post Operative Day Baseline POD4 DCD30min + 8h NEVKP (n=5) DCD30min + 8h SCS (n=5) DCD30min + 8h NEVKP (n=5)

Supplemental Figure 2. 8-day post-operative renal graft function measured through A. serum creatinine expressed as mean +/- standard deviation and B. creatinine clearance obtained following 24hr urine collection also expressed as mean +/- standard deviation. *p<0.05. DCD: Donation-after-cardiac death. POD: post-operative day. SCS: static cold storage. NEVKP: Normothermic Ex-Vivo Kidney Perfusion 50

14 * 1200 40 12 * 1000 10 30 800 8 20 600 6 * 400 4 10 Serum Creatinine (mg/dL) Serum Creatinine 200 (µmol/L) Serum Creatinine 2 0 Creatinine Clearance (ml/min) Clearance Creatinine 0 0 POD 3 Baseline 1 2 3 Post Operative Day DCD30min + 8h NEVKP (n=3) DCD30min + 8h NEVKP (n=3) DCD30min + 8h SCS (n=3) DCD30min + NS (n=3) DCD30min + NS (n=3) DCD30min + 8h SCS (n=3)

Supplemental Figure 3. 3-day post-operative renal graft function of specimens used for microarray analysis measured through A. serum creatinine expressed as mean +/- standard deviation and B. creatinine clearance obtained following 24hr urine collection also expressed as mean +/- standard deviation. *p<0.05 compared to either NEVKP or NS group. DCD: Donation-after-cardiac death. POD: post-operative day. SCS: static cold storage. NEVKP: Normothermic Ex-Vivo Kidney Perfusion. NS: No Storage Forward Primer 5'-3' Reverse Primer 5"-3" TBP1 AACAGTTCAGTAGTTATGAGCCAGA AGATGTTCTCAAACGCTTCG UMOD CAAGTCGGATAATGGCAAATGG CACTTGCTCAGGGACATCTT RBP4 CCTCCAGAAAGG AAACGATGA GGGCAAACACGAAGGAGTA MPC2 CCTCTCAGCTCTTCCGTATTTG CAAACTAGGTCCCAGTGGTTATG GALNT11 TTCAACGTGGAAGGCTCTATC ATCAGGGTCACCGTAGTCA PROM1 GCTAGAGCACGCCTACAATATC CCTTCCTCATCCACCTTCATTAC

Supplementary Table 1: List of primers utilized for internal validation of microarray results utilizing quantitative reverse-transcriptase polymerase chain reaction. Supplementary Table 2: Differentially Expressed between Static Cold Storage and No-Storage of Kidneys Probe ID HGNC Identifier Additional Annotation logFC in SCS wAveExpr P.Value adj.P.Val 15274170 UMOD uromodulin -2.2525602 11.0595161 0.00187892 0.04320137 15330275 PLET1 placenta expressed transcript 1 -2.1505172 7.75301223 0.00108196 0.04093857 15294918 SLC5A8 5 member 8 -1.9965187 4.76605691 0.00272561 0.04822607 15217592 KNG1 kininogen 1 -1.933088 9.45121031 0.00118137 0.04093857 15283532 SLC26A7 solute carrier family 26 member 7 -1.8612124 8.42039964 0.00058876 0.03931424 15281713 SLC16A4 solute carrier family 16 member 4 -1.854482 9.31489005 0.00067451 0.03982804 15334658 VSIG1 V-set and immunoglobulin domain co-1.8334947 5.50330168 0.00136065 0.04110148 15330824 SIAE sialic acid acetylesterase -1.7555774 7.84192217 9.01E-05 0.03850992 15286875 LRRC8B rich repeat containing 8 VRAC -1.7029981 6.81658788 0.00230506 0.04519769 15223630 AADAT aminoadipate aminotransferase -1.6997545 9.62865478 0.00011445 0.03850992 15291169 CYP2D6 vitamin D3 25-Hydroxylase -1.6711564 7.46539085 0.00015403 0.03850992 15218761 KCNJ15 potassium voltage-gated channel sub-1.636074 10.4645971 0.00024448 0.03850992 15193527 DDO D-aspartate oxidase -1.610899 8.67598064 0.00018102 0.03850992 15281348 CASQ2 calsequestrin 2 -1.6024776 7.65930123 9.61E-06 0.03850992 15265909 BHMT betaine--homocysteine S-methyltrans -1.5643616 9.53824641 0.00200785 0.04399721 15292973 AVPR1A arginine vasopressin 1A -1.5634325 5.79405825 0.00022971 0.03850992 15329730 RAB30 PREDICTED: Sus scrofa RAB30, memb-1.5490232 7.04271254 0.0001523 0.03850992 15252166 ATP6V0A4 ATPase H+ transporting V0 subunit a4 -1.54733 8.44029403 0.00062813 0.03967531 15316824 RHCG Rh family C glycoprotein -1.5414203 7.67684581 0.00128199 0.04093857 15239643 SLC38A11 PREDICTED: Sus scrofa putative sodiu-1.4942519 5.13682631 2.91E-05 0.03850992 15326771 GLB1L2 beta-galactosidase-1-like 2 -1.4761513 7.04977438 0.00026845 0.03850992 15232054 MTR 5-methyltetrahydrofolate-homocyste-1.468887 8.05121837 3.21E-05 0.03850992 15258518 BHMT betaine--homocysteine S-methyltrans -1.4659728 10.2126542 0.00174443 0.04255231 15332793 DDC dopa decarboxylase -1.4655742 9.47102618 0.00209151 0.04399721 15232327 SLC16A9 solute carrier family 16 member 9 -1.459386 9.34535284 0.00207319 0.04399721 15191953 SLC22A1 solute carrier family 22 member 1 -1.4537212 9.76384652 0.00051821 0.03931424 15285077 RHBG Rh family B glycoprotein -1.4464682 6.3105154 0.0004284 0.03850992 15250517 ATP6V0A4 ATPase H+ transporting V0 subunit a4 -1.4450954 7.60859836 0.00058147 0.03931424 15321532 ETNPPL ethanolamine-phosphate phospho-ly -1.4361644 5.04400296 0.00081567 0.04093857 15184490 RRAGD Ras related GTP binding D -1.4150207 6.86169949 0.00139445 0.04115561 15223603 HPGD 15-hydroxyprostaglandin dehydrogen -1.409796 9.63473155 0.00023517 0.03850992 15222311 SLC15A2 solute carrier family 15 member 2 -1.3942382 8.87761224 0.00141093 0.04118107 15289377 TMEM52B transmembrane protein 52B -1.3910002 10.9499073 0.00215183 0.0443154 15257357 ADGRE2 PREDICTED: Sus scrofa adhesion G pr -1.3828302 6.20133055 0.00041406 0.03850992 15214333 TMEM220 transmembrane protein 220 -1.3592659 6.41948148 0.00251306 0.04634385 15252159 TMEM213 transmembrane protein 213 -1.3583597 8.0360328 0.00109831 0.04093857 15293758 TMEM52B transmembrane protein 52B -1.341388 10.3533375 0.00290331 0.04923998 15295360 MIOX myo- -1.3275298 10.2344846 0.00021628 0.03850992 15324138 EGF epidermal growth factor -1.3116287 9.91982881 0.00228341 0.04519769 15184835 DDO D-aspartate oxidase -1.2990983 8.08752521 0.00021524 0.03850992 15188830 TTC39B tetratricopeptide repeat domain 39B -1.2779151 8.24560565 0.00220936 0.04441719 15326817 FMO1 flavin containing 1 -1.2592556 10.5328777 0.00128395 0.04093857 15216842 ACAD11 acyl-CoA dehydrogenase family mem-1.2587255 8.19225643 0.0023249 0.04519769 15195879 RNF152 ring finger protein 152 -1.2564696 8.83390361 7.61E-05 0.03850992 15286017 HAO2 hydroxyacid oxidase 2 -1.2488381 10.0681958 0.00070085 0.04004185 15284003 ADHFE1 alcohol dehydrogenase, containi-1.2470243 8.81580072 0.00208626 0.04399721 15186328 GATM glycine amidinotransferase -1.2437426 11.4095024 0.00060214 0.03931424 15298795 CLCNKA protein ClC-Ka -1.2383633 6.8995005 0.00255132 0.04661954 15196418 CDKL1 cyclin dependent kinase like 1 -1.2368748 8.72987519 0.00038233 0.03850992 15283751 PKIA cAMP-dependent inhib-1.2289426 7.80117085 0.00263462 0.04790934 15318469 ALDH6A1 aldehyde dehydrogenase 6 family me-1.2263468 10.5046305 0.00279924 0.04867182 15290997 PPARA peroxisome proliferator activated rec-1.2245271 8.93515801 0.00063165 0.03967531 15209183 MIR22 MI0014770 Sus scrofa miR-22 stem-l-1.2231785 5.1746772 0.00292152 0.04923998 15235671 ACSL1 acyl-CoA synthetase long chain family -1.2230393 9.57549208 0.00172729 0.04233973 15265903 DMGDH dimethylglycine dehydrogenase -1.2208342 5.05609227 0.00019283 0.03850992 15235707 ACSL1 acyl-CoA synthetase long chain family -1.2204653 9.77695719 0.00297105 0.04923998 15306709 SCP2 sterol carrier protein 2 -1.2142381 10.3182302 0.00276962 0.04832403 15327201 PON3 paraoxonase 3 -1.2138402 9.27076932 0.00245479 0.04585614 15183880 VNN1 vanin 1 -1.2127704 8.96124787 0.00159977 0.04122489 15334204 SLC16A2 solute carrier family 16 member 2 -1.2115929 9.06390724 0.00061025 0.03931424 15248865 SLC52A3 solute carrier family 52 member 3 -1.2033153 6.45518329 0.00011578 0.03850992 15225281 TCN2 transcobalamin 2 -1.1895672 8.75030208 0.00189857 0.04320137 15219252 ACAA1 acetyl-CoA acyltransferase 1 -1.1869481 9.24887875 8.99E-05 0.03850992 15246952 TLDC2 TBC/LysM-associated domain contain-1.1852484 6.55589706 0.00136657 0.04110148 15258523 BHMT betaine--homocysteine S-methyltrans -1.1818677 10.8626933 0.00013759 0.03850992 15232522 SNORA70 Small nucleolar RNA SNORA70 [gene_ -1.1776291 7.17985935 0.00091223 0.04093857 15196736 DHRS7 dehydrogenase/reductase 7 -1.1722401 8.71093085 0.00210281 0.04399721 15325405 NOX4 NADPH oxidase 4 -1.1696809 9.97524235 0.00132311 0.04093857 15218934 HACL1 2-hydroxyacyl-CoA 1 -1.1678024 7.4051617 0.0007375 0.04072472 15242703 GHR growth -1.1665368 7.90913789 0.00265138 0.04790934 15194797 SLC28A2 solute carrier family 28 member 2 -1.1647771 4.80990396 0.00036891 0.03850992 15323311 CDKL2 cyclin dependent kinase like 2 -1.162553 6.32030568 0.0004371 0.03853347 15287837 AQP2 2 -1.1526515 6.75533504 0.0016376 0.04198446 15263446 PLIN4 perilipin 4 -1.1464115 6.0172954 0.00042917 0.03850992 15289263 SMCO3 single-pass with co-1.1451551 9.18212817 0.00080817 0.04093857 15326909 MFSD4A major facilitator superfamily domain -1.1407722 6.21685037 0.00296128 0.04923998 15200003 COQ8A coenzyme Q8A -1.1374885 7.55291762 0.00026751 0.03850992 15266362 STARD4 StAR related lipid transfer domain con-1.1286364 6.96633386 0.00097997 0.04093857 15243765 SLC6A18 solute carrier family 6 member 18 -1.1234482 10.2465112 0.00205324 0.04399721 15251796 GALNT11 polypeptide N-acetylgalactosaminyltr-1.1199456 9.29788622 0.00037263 0.03850992 15298787 AGMAT agmatinase -1.118201 8.5722986 0.00030921 0.03850992 15185592 CA12 carbonic anhydrase 12 -1.1178353 9.42065027 0.00068163 0.03982804 15239744 CERS6 ceramide synthase 6 -1.1135651 6.22533331 0.00076904 0.04093857 15260795 PC pyruvate carboxylase -1.1108207 9.80164935 0.00026138 0.03850992 15229495 PEBP4 phosphatidylethanolamine binding pr-1.1097001 5.21571516 0.00155336 0.04122489 15203973 CPB2 carboxypeptidase B2 -1.1063164 9.89763413 0.00183254 0.04320137 15231972 RYR2 2 -1.1058737 5.12151572 0.00015608 0.03850992 15249725 SLC13A3 solute carrier family 13 member 3 -1.1054848 9.87079508 0.00127449 0.04093857 15265897 LHFPL2 LHFPL tetraspan subfamily member 2 -1.104258 9.10423639 0.00013176 0.03850992 15257439 CYP4F2 cytochrome P450, family 4, subfamily -1.1013848 5.38291606 0.00071023 0.04010009 15291888 GPD1 glycerol-3-phosphate dehydrogenase -1.0992413 8.04184804 0.00156342 0.04122489 15270837 EVA1A PREDICTED: Sus scrofa eva-1 homolo -1.0943065 6.8869713 0.0004489 0.03889205 15189714 ALDH1B1 aldehyde dehydrogenase 1 family me-1.0766303 8.17835111 0.00060991 0.03931424 15183265 SLC22A2 solute carrier family 22 member 2 -1.076417 10.5506306 0.0001197 0.03850992 15193104 GJB7 protein beta 7 -1.0645149 6.88055762 0.0014908 0.04118107 15329233 FOLR2 receptor 2 (fetal) -1.0520195 9.3739059 0.00184418 0.04320137 15308597 APOM apolipoprotein M -1.0516097 6.7990022 0.00101177 0.04093857 15258350 TMEM174 transmembrane protein 174 -1.0449534 7.58467809 0.00195588 0.04387628 15335836 ACE2 angiotensin I converting 2 -1.0315683 8.74949281 0.0019 0.04320137 15200721 AQP7 aquaporin 7 -1.0252517 7.60785624 0.00150547 0.04118107 15230752 TMEM116 transmembrane protein 116 -1.0239655 7.83959259 0.00087025 0.04093857 15264729 ADGRE2 PREDICTED: Sus scrofa adhesion G pr -1.0146042 5.51601921 0.00117794 0.04093857 15302352 PEPD peptidase D -1.0106106 9.73063014 0.00126643 0.04093857 15189710 ALDH1B1 aldehyde dehydrogenase 1 family me-1.0036526 9.00085836 0.00042081 0.03850992 15228691 HSPA12A heat shock A (Hsp70) m-0.9938959 6.84174144 0.00093655 0.04093857 15215169 PTH1R parathyroid hormone 1 receptor -0.9922387 9.19941851 0.00052218 0.03931424 15327919 SERPINC1 serpin family C member 1 -0.9909737 5.09807106 0.00098203 0.04093857 15235425 TMEM37 transmembrane protein 37 -0.9893685 8.82852445 0.00148276 0.04118107 15189350 PSAT1 phosphoserine aminotransferase 1 -0.9883674 10.0245196 0.00222155 0.04441719 15317509 PCK2 phosphoenolpyruvate carboxykinase -0.9861967 8.81625194 0.00051721 0.03931424 15323375 CXCL9 C-X-C motif chemokine ligand 9 -0.9861114 5.35034065 0.00285848 0.04901813 15221126 ACAD11 acyl-CoA dehydrogenase family mem-0.972543 8.89250281 0.00058334 0.03931424 15215380 SHISA5 shisa family member 5 -0.9718348 6.5810991 0.00050822 0.03931424 15297853 ASPDH aspartate dehydrogenase domain con -0.9644843 7.04826494 0.00072155 0.04028645 15267297 STK32A PREDICTED: Sus scrofa serine -0.960661 4.41044996 0.00137677 0.04110148 15330586 SLC37A4 solute carrier family 37 member 4 -0.9605613 9.6537476 0.00109795 0.04093857 15199571 GRHPR glyoxylate/hydroxypyruvate reductas -0.9603439 6.70615425 0.00066812 0.03982804 15224848 ACADS acyl-CoA dehydrogenase short chain -0.9588801 8.88442095 0.00189059 0.04320137 15221173 TF -0.9520596 8.24435427 0.00100329 0.04093857 15224621 TPCN1 two pore segment channel 1 -0.9479867 7.92889765 0.0014931 0.04118107 15222185 SLC51A solute carrier family 51 alpha subunit -0.9448993 7.53043282 0.00099695 0.04093857 15278361 NCALD neurocalcin delta -0.9439871 7.91636189 0.00084227 0.04093857 15201936 PSEN2 presenilin 2 -0.9402009 8.80143738 0.00240963 0.0455202 15335816 VEGFD vascular endothelial growth factor D -0.9393785 6.74785893 0.00047556 0.03931424 15211009 ACE angiotensin I converting enzyme (pep -0.9391196 7.87579099 0.0020094 0.04399721 15254088 SLC25A45 solute carrier family 25 member 45 -0.9386197 6.82272535 0.00028928 0.03850992 15261845 GLYAT glycine N-phenylacetyltransferase -0.927024 10.954239 0.00284433 0.04901813 15242661 EGFLAM EGF like, fibronectin type III and lamin-0.9268674 5.33620934 0.00203487 0.04399721 15233852 CPN1 carboxypeptidase N subunit 1 -0.9171568 4.55033303 0.00274195 0.04832403 15221931 EHHADH PREDICTED: Sus scrofa enoyl-CoA, hy -0.9141117 10.5628841 0.00133078 0.04093857 15222362 PLA1A phospholipase A1 member A -0.913096 8.64275741 0.00085612 0.04093857 15202830 MPP7 membrane palmitoylated protein 7 -0.9115428 7.17977321 0.00041274 0.03850992 15221751 MECOM MDS1 and EVI1 complex -0.9033914 6.33775115 0.00153612 0.04118107 15324590 CDS1 CDP-diacylglycerol synthase 1 -0.9025553 7.62155363 0.00289247 0.04923998 15223644 MFAP3L microfibril associated protein 3 like -0.9016013 8.16611649 0.0013 0.04093857 15203298 CRYL1 crystallin lambda 1 -0.8983483 10.6511018 0.00039435 0.03850992 15303711 ASPDH aspartate dehydrogenase domain con -0.8955621 6.81152342 0.00104064 0.04093857 15254119 NAALADL1 N-acetylated alpha-linked acidic dipep-0.8911467 8.14167187 0.00127456 0.04093857 15317570 DHRS4 dehydrogenase/reductase (SDR famil -0.8874433 8.08025339 0.00152827 0.04118107 15236478 BBS5 Bardet-Biedl syndrome 5 -0.8837591 7.28727162 0.00204619 0.04399721 15311163 STRA6 stimulated by retinoic acid 6 -0.880659 9.25317154 0.00098715 0.04093857 15287141 SCUBE1 signal peptide, CUB domain and EGF l-0.8805278 6.32106716 0.00213052 0.04405702 15318645 GSTZ1 glutathione S- zeta 1 -0.8773326 9.06233321 0.00244095 0.0457678 15233395 PANK1 pantothenate kinase 1 -0.8700781 7.75888111 0.00095061 0.04093857 15237168 PLCL1 phospholipase C like 1 -0.8606166 6.64984294 0.00170645 0.04233973 15263453 PLIN5 perilipin 5 -0.8515348 6.79823381 0.00198237 0.04399721 15288532 SLC16A7 solute carrier family 16 member 7 -0.8512119 8.22401205 0.0012215 0.04093857 15253835 PC pyruvate carboxylase -0.8484427 9.35531099 0.0011555 0.04093857 15188439 PCNX4 pecanex homolog 4 -0.8475867 7.02382503 0.00067308 0.03982804 15284304 SFT2D2 SFT2 domain containing 2 -0.8469722 8.34909216 0.00298105 0.04923998 15223580 MSRA methionine sulfoxide reductase A -0.8465643 8.09889618 0.00159062 0.04122489 15275708 RETSAT retinol saturase -0.8331618 8.6196155 0.00272366 0.04822607 15202871 MSRB2 methionine sulfoxide reductase B2 -0.8324277 6.42099901 0.00252701 0.04634385 15218375 NIT2 nitrilase family member 2 -0.8306325 10.2102784 0.00138232 0.04110148 15337351 RPS6KA6 ribosomal protein S6 kinase A6 -0.8305923 5.04747332 0.00104162 0.04093857 15306255 MIGA1 mitoguardin 1 -0.8253629 8.53533261 0.00210571 0.04399721 15216920 PCCB propionyl-CoA carboxylase beta subu -0.8149439 9.33109126 0.00181147 0.04320137 15203195 ASB13 ankyrin repeat and SOCS box containi-0.8119507 7.95986709 0.00125461 0.04093857 15251268 HIBADH NA -0.8116683 9.53040816 0.00298778 0.04923998 15319646 GCM1 glial cells missing homolog 1 -0.8113137 5.4718426 0.00211011 0.04399721 15310539 HOMER2 homer scaffolding protein 2 -0.8094877 6.99149439 0.00251285 0.04634385 15287845 AQP6 aquaporin 6 -0.8076092 6.65025363 0.00230913 0.04519769 15227930 HOGA1 4-hydroxy-2-oxoglutarate aldolase 1 -0.8065367 8.37016302 0.00168842 0.04233973 15259441 SOWAHA sosondowah ankyrin repeat domain f-0.803795 5.08369162 0.00129074 0.04093857 15213880 ACADVL acyl-CoA dehydrogenase very long ch -0.7994078 8.88690494 0.00105876 0.04093857 15191219 ASS1 argininosuccinate synthase 1 -0.7896293 10.4717335 0.00240812 0.0455202 15203730 SLC25A15 solute carrier family 25 member 15 -0.7817276 8.33373039 0.00219242 0.04441719 15201551 B3GALT2 beta-1,3-galactosyltransferase 2 -0.7735281 6.00884795 0.00286793 0.04901813 15330668 USP2 ubiquitin specific peptidase 2 -0.7720521 7.83116184 0.00233859 0.04519769 15216646 XPC XPC complex subunit, DNA damage re-0.7681109 8.48366951 0.00102996 0.04093857 15224315 ACAD10 acyl-CoA dehydrogenase family mem-0.7657572 7.2880365 0.0015407 0.04118107 15207185 ARL4D ADP ribosylation factor like GTPase 4D -0.761903 6.86640486 0.00201706 0.04399721 15312526 MPP5 membrane palmitoylated protein 5 -0.7608178 9.31591151 0.00251976 0.04634385 15235730 SLC25A4 solute carrier family 25 member 4 -0.7580423 8.64261045 0.00183282 0.04320137 15241420 GLB1L galactosidase beta 1 like -0.7508063 8.68327086 0.00251219 0.04634385 15287255 PMM1 phosphomannomutase 1 -0.7473246 8.61425485 0.00221844 0.04441719 15289703 SCNN1A epithelial 1 alpha sub -0.7422493 7.78582402 0.00238528 0.0455202 15216634 SLC6A6 PREDICTED: Sus scrofa solute carrier -0.7061557 8.90335896 0.00187117 0.04320137 15320832 AFP PREDICTED: Sus scrofa alpha-fetopro1.86718669 4.18268769 0.00108452 0.04093857 15306304 SNORD45A Small nucleolar RNA SNORD45 [gene_1.80257296 8.31652 0.0010968 0.04093857 15233495 RBP4 retinol binding protein 4 1.77660574 9.0467007 0.00042823 0.03850992 15332091 CHI3L1 chitinase 3 like 1 1.63482802 6.96640428 0.00038562 0.03850992 15333754 TIMP1 TIMP metallopeptidase inhibitor 1 1.61782873 9.59894874 3.71E-05 0.03850992 15285575 S100A12 S100 calcium binding protein A12 1.57970644 5.84605829 0.00060656 0.03931424 15212667 CCL2 chemokine (C-C motif) ligand 2 1.55167759 8.68897814 4.82E-05 0.03850992 15289012 ARNTL2 aryl hydrocarbon receptor nuclear tra1.53617415 6.32320367 0.00243356 0.0457678 15253165 CREB5 cAMP responsive element binding pro1.50414671 7.30999746 0.00017403 0.03850992 15327424 IL6 interleukin 6 1.43857846 5.63711459 0.00132934 0.04093857 15291504 LGALS1 galectin 1 1.40927729 8.75076932 8.16E-05 0.03850992 15327562 SEMA3C semaphorin 3C 1.39701851 6.52730582 0.00118247 0.04093857 15242410 CDH6 cdna:genscan :Sscrofa1 1.34810414 6.40754475 7.29E-05 0.03850992 15338844 MXRA5 matrix-remodeling-associated protein 1.34469557 7.22406912 0.00102822 0.04093857 15233671 PIK3AP1 phosphoinositide-3-kinase adaptor pr1.33906718 9.07523784 6.14E-05 0.03850992 15300119 ASXL3 additional sex combs like 3, transcript1.33136134 6.07528089 0.002031 0.04399721 15284447 RGS4 regulator of G protein signaling 4 1.31754759 5.62802904 0.00136534 0.04110148 15241173 FN1 fibronectin 1 1.29294679 10.0409804 0.00057173 0.03931424 15278087 HAS2 hyaluronan synthase 2 1.29146779 4.64828829 0.00096041 0.04093857 15210755 SOX9 SRY-box 9 1.2504116 7.5420958 0.00055374 0.03931424 15314344 HIST3H3 ensembl:novel chromosome:Sscrofa1 1.24660745 8.69069419 0.00022417 0.03850992 15226844 PLAU plasminogen activator, urokinase 1.22953545 7.7555669 0.00053523 0.03931424 15259521 TGFBI transforming growth factor beta indu 1.21427169 9.47223322 0.00151305 0.04118107 15211142 ITGB3 integrin subunit beta 3 1.21410594 6.40076687 0.000265 0.03850992 15326682 TMEM45B transmembrane protein 45B 1.21167415 5.60964063 0.00203534 0.04399721 15233460 MYOF myoferlin 1.19314504 8.36426205 0.00059412 0.03931424 15228566 PLEKHS1 pleckstrin homology domain containi 1.1717667 5.29622523 0.0001479 0.03850992 15234867 ADAM12 ADAM metallopeptidase domain 12 1.16543124 6.46379062 0.0008702 0.04093857 15282773 MYC proto-oncogene, bHLH transcrip1.14116313 7.94493192 0.00030456 0.03850992 15319241 HHIPL1 HHIP like 1 1.14056028 6.96088601 0.00171114 0.04233973 15218535 ADAMTS1 ADAM metallopeptidase with thromb1.13273452 9.01537231 0.0016662 0.04228605 15208134 ITGA3 integrin subunit alpha 3 1.12162513 8.93987681 0.00087646 0.04093857 15303123 PLAUR PREDICTED: Sus scrofa plasminogen a1.11341548 7.04214335 0.00113808 0.04093857 15212125 COL1A1 collagen type I alpha 1 chain 1.10774678 11.2314993 0.0010355 0.04093857 15263463 LRG1 leucine rich alpha-2-glycoprotein 1 1.10077357 7.06680997 0.00189442 0.04320137 15294167 TEAD4 TEA domain 4 1.09238991 6.75026776 0.00041906 0.03850992 15287965 KRT18 keratin 18 1.08686669 8.51044285 0.00070123 0.04004185 15290794 NAV3 PREDICTED: Sus scrofa neuron naviga1.06707245 6.27604413 0.0013361 0.04093857 15313137 FLRT2 fibronectin leucine rich transmembra1.06640595 8.52403117 0.00094533 0.04093857 15242875 GPX8 glutathione peroxidase 8 (putative) 1.05687288 6.18905093 0.00039926 0.03850992 15244489 GPX8 glutathione peroxidase 8 (putative) 1.05687288 6.18905093 0.00039926 0.03850992 15208156 COL1A1 collagen alpha-1(I) chain 1.03114981 9.40268646 0.00119158 0.04093857 15319844 HTRA3 HtrA serine peptidase 3 1.02879699 7.58254792 0.0004629 0.03931424 15314360 HIST1H2AH histone H2A type 1-H 1.02863451 8.19337574 0.00087491 0.04093857 15283880 SULF1 sulfatase 1 1.02567956 6.31520762 0.00144085 0.04118107 15218618 RUNX1 runt related transcription factor 1 1.02253563 6.71283639 0.0012303 0.04093857 15308014 HIST1H2AH histone H2A type 1-H 1.01296801 10.3285574 0.00158526 0.04122489 15227964 CRTAC1 cartilage acidic protein 1 1.01294041 6.94359801 0.00271577 0.04822607 15212139 ITGA3 integrin subunit alpha 3 1.00622252 7.94500881 0.00112499 0.04093857 15233751 LOXL4 lysyl oxidase like 4 0.99373199 5.9907751 0.00105605 0.04093857 15302117 ADGRG1 adhesion G protein-coupled receptor 0.98846342 8.03524803 0.0009091 0.04093857 15262093 SPI1 Spi-1 proto-oncogene 0.98027237 6.78415933 0.00119486 0.04093857 15301647 MLKL mixed lineage kinase domain like pse 0.98002041 6.54540204 0.00239847 0.0455202 15239264 NRG1 PREDICTED: Sus scrofa pro-neureguli0.97971718 7.39365591 0.00187887 0.04320137 15212042 ABCC3 ATP binding cassette subfamily C mem0.97834298 6.4376788 0.00126056 0.04093857 15314358 HIST1H3B histone H3 0.97825986 9.89049394 0.00097786 0.04093857 15314354 HIST1H2BK histone H2B type 1-K 0.97725251 10.344985 0.00144355 0.04118107 15207371 FKBP10 FK506 binding protein 10 0.97523091 7.39498357 0.00125718 0.04093857 15286267 RHOC ras homolog family member C 0.97307491 7.30301156 0.00051864 0.03931424 15189179 ANXA1 annexin A1 0.96240433 9.19094277 0.0019448 0.04382331 15307975 HIST1H3A histone H3 0.95552784 9.88032598 0.0010789 0.04093857 15314301 HIST1H3C histone H3 0.95552784 9.88032598 0.0010789 0.04093857 15247177 MYBL2 MYB proto-oncogene like 2 0.95286238 7.19082883 0.00233746 0.04519769 15286425 CSF1 colony stimulating factor 1 0.95267704 8.14434425 0.00042269 0.03850992 15314342 HIST1H2BN histone cluster 1, H2bh [gene_biotyp 0.94083307 6.26985422 0.00233427 0.04519769 15228428 DUSP5 dual specificity phosphatase 5 0.92580028 7.97862003 0.00057556 0.03931424 15314348 HIST1H2AA histone H2A type 1-like 0.91592549 7.72811553 0.00118148 0.04093857 15267774 FSCN1 fascin -bundling protein 1 0.90832328 6.67725679 0.00181445 0.04320137 15281028 HIST1H3A histone H3 0.89757086 9.40784772 0.00108376 0.04093857 15327125 COL1A2 collagen type I alpha 2 chain 0.89097037 10.3957329 0.00123794 0.04093857 15307917 SLC17A3 solute carrier family 17 member 3 0.88395942 6.11127819 0.00217737 0.04441719 15303171 PVR poliovirus receptor homolog 0.88227504 6.24075974 0.00281393 0.04875862 15305309 NKAIN1 sodium/potassium transporting ATPa0.87832374 5.08464841 0.00057384 0.03931424 15262582 RCN1 reticulocalbin 1 0.87492333 7.35089066 0.00166524 0.04228605 15329312 P2RY6 pyrimidinergic receptor P2Y6 0.87037847 5.58554049 0.00118419 0.04093857 15222862 RCAN1 regulator of calcineurin 1 0.86970787 7.34945712 0.0015982 0.04122489 15234730 GMFG glia maturation factor gamma 0.86865273 7.44683105 0.00275332 0.04832403 15314307 HIST1H2AA histone H2A type 1 0.86743529 8.37768377 0.00133324 0.04093857 15281736 CSF1 colony stimulating factor 1 0.85992536 7.13417706 0.0019159 0.04336661 15222129 TMEM44 transmembrane protein 44 0.8543411 5.20240778 0.00081599 0.04093857 15204149 KLF5 Kruppel like factor 5 0.84340597 7.51896611 0.00140052 0.04115561 15276672 PKDCC protein kinase domain containing, cyt 0.84225536 8.23758744 0.00064747 0.03967709 15258278 HK3 hexokinase 3 0.83298294 5.50535896 0.00267911 0.04790934 15207463 KRT19 keratin 19 0.83186239 10.1242345 0.00147394 0.04118107 15262224 CREB3L1 cAMP responsive element binding pro0.8294057 7.46111356 0.0017628 0.04258687 15218161 CCDC80 coiled-coil domain containing 80 0.8284091 7.35847709 0.00296953 0.04923998 15212122 COL1A1 collagen type I alpha 1 chain 0.82149674 12.527341 0.00189746 0.04320137 15308020 HIST1H2BN PREDICTED: Sus scrofa histone H2B ty0.81960334 6.7977529 0.00157469 0.04122489 15266425 SEMA6A semaphorin 6A 0.80902985 9.11968741 0.00064114 0.03967709 15249789 PTGIS prostaglandin I2 synthase 0.80558178 7.47574997 0.00169619 0.04233973 15285539 S100A2 S100 calcium binding protein A2 0.80517331 5.56643696 0.00146754 0.04118107 15212538 ACACA acetyl-CoA carboxylase alpha 0.80087488 6.89821875 0.0021287 0.04405702 15223624 HMGB2 high mobility group box 2 0.79949275 8.0819231 0.00267151 0.04790934 15239268 NRG1 PREDICTED: Sus scrofa pro-neureguli0.77931394 4.56640768 0.00102344 0.04093857 15307979 HIST1H2BM histone H2B type 1-M 0.77507067 8.32838822 0.00097095 0.04093857 15281589 MOV10 Mov10 RISC complex RNA helicase 0.77501967 7.45185515 0.00207949 0.04399721 15324845 CAVIN3 caveolae associated protein 3 0.77374949 8.45856266 0.00152072 0.04118107 15270772 TMSB10 thymosin beta 10 0.77022568 11.1161012 0.00207284 0.04399721 15243284 LCP2 lymphocyte cytosolic protein 2 0.77020366 6.69853167 0.00176209 0.04258687 15247014 TGM2 transglutaminase 2 0.76635323 7.96894082 0.00149005 0.04118107 15249394 TGM2 transglutaminase 2 0.76559578 7.96553181 0.00144838 0.04118107 15300578 JUN Jun proto-oncogene, AP-1 transcriptio0.76198151 9.21747635 0.00285811 0.04901813 15311754 PSME2 proteasome activator subunit 2 0.73716512 7.7665752 0.00171736 0.04233973 15272930 ZFAND2A AN1-type containing 2A 0.72985914 6.02501611 0.00222749 0.04441719 15223879 SCARB1 scavenger receptor class B member 1 0.70852262 8.16519665 0.00218543 0.04441719 15273271 PILRA paired immunoglobin like type 2 rece0.7056307 4.66086204 0.00267672 0.04790934 15332610 VASH2 vasohibin 2 0.70443461 6.35124858 0.00236755 0.0455202 15202099 ASPM PREDICTED: Sus scrofa abnormal spin0.69346741 5.4249418 0.00298169 0.04923998 15248786 SIRPA signal regulatory protein alpha 0.68574263 6.66880154 0.002763 0.04832403 15206385 NT5C 5', 3'-nucleotidase, cytosolic 0.6827097 6.25559721 0.00231313 0.04519769 15270341 CHST10 carbohydrate sulfotransferase 10 0.68233986 7.51397494 0.00218084 0.04441719 15292386 MMP19 matrix metallopeptidase 19 0.67795724 6.47003345 0.00295372 0.04923998 Supplementary Table 3: Pathways Up-Regulated in Static Cold Storage Kidneys vs Non-Stored Kidneys source term_name term_id adjusted_p_vnegative_log term_size query_size intersection_ effective_domain_size REAC Interleukin-4 and Interleukin-13 signaling REAC:R-HSA- 0.000164 3.78515604 111 64 8 10478 REAC Post-translational protein REAC:R-HSA- 0.00019209 3.71649803 107 18 5 10478 REAC Pre-NOTCH Transcription and Translation REAC:R-HSA- 0.00019937 3.70033905 93 90 8 10478 REAC Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding (IGFBPs) REAC:R-HSA- 0.00019984 3.69930895 124 18 5 10478 REAC Pre-NOTCH Expression and Processing REAC:R-HSA- 0.00039908 3.39894197 109 90 8 10478 REAC Estrogen-dependent gene expression REAC:R-HSA- 0.00040657 3.39086895 149 90 9 10478 REAC HDACs deacetylate histones REAC:R-HSA- 0.000475 3.32330608 94 84 7 10478 REAC ESR-mediated signaling REAC:R-HSA- 0.000475 3.32330608 155 90 9 10478 REAC Interleukin-10 signaling REAC:R-HSA- 0.000475 3.32330608 45 10 3 10478 REAC Formation of the beta-catenin:TCF transactivating complex REAC:R-HSA- 0.000475 3.32330608 91 84 7 10478 REAC RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function REAC:R-HSA- 0.00057493 3.24038274 97 85 7 10478 REAC RUNX1 regulates transcription of genes involved in differentiation of HSCs REAC:R-HSA- 0.00066621 3.17638619 130 91 8 10478 REAC Signaling by Interleukins REAC:R-HSA- 0.00070396 3.15245059 461 64 12 10478 REAC Syndecan interactions REAC:R-HSA- 0.00070396 3.15245059 27 64 4 10478 REAC Condensation of Prophase REAC:R-HSA- 0.0008074 3.09290959 73 84 6 10478 REAC Signaling by NOTCH REAC:R-HSA- 0.00090495 3.04337324 232 91 10 10478 REAC MET activates PTK2 signaling REAC:R-HSA- 0.00090495 3.04337324 30 64 4 10478 REAC Cellular Senescence REAC:R-HSA- 0.00103352 2.98567935 193 90 9 10478 REAC Extracellular matrix organization REAC:R-HSA- 0.00103352 2.98567935 299 34 7 10478 REAC Senescence-Associated Secretory Phenotype (SASP) REAC:R-HSA- 0.00104344 2.98153211 110 90 7 10478 REAC Signaling by Nuclear Receptors REAC:R-HSA- 0.00113332 2.94564785 198 90 9 10478 REAC Meiotic recombination REAC:R-HSA- 0.00149356 2.8257782 87 84 6 10478 REAC Platelet Aggregation (Plug Formation) REAC:R-HSA- 0.00171374 2.76605488 38 64 4 10478 REAC Oxidative Stress Induced Senescence REAC:R-HSA- 0.00177352 2.75116328 123 90 7 10478 REAC MET promotes cell motility REAC:R-HSA- 0.00193425 2.7134866 40 64 4 10478 REAC RHO GTPases activate PKNs REAC:R-HSA- 0.00194878 2.71023803 94 84 6 10478 REAC Integrin cell surface interactions REAC:R-HSA- 0.00243874 2.61283492 84 34 4 10478 REAC HATs acetylate histones REAC:R-HSA- 0.00243874 2.61283492 142 84 7 10478 REAC RNA Polymerase I Opening REAC:R-HSA- 0.00243874 2.61283492 63 84 5 10478 REAC Amyloid fiber formation REAC:R-HSA- 0.00243874 2.61283492 100 84 6 10478 REAC Crosslinking of collagen fibrils REAC:R-HSA- 0.00256232 2.59136628 18 64 3 10478 REAC DNA methylation REAC:R-HSA- 0.00256232 2.59136628 65 84 5 10478 REAC TCF dependent signaling in response to WNT REAC:R-HSA- 0.00264835 2.57702479 232 91 9 10478 REAC Activated PKN1 stimulates transcription of AR () regulated genes KLK2 and KLK3 REAC:R-HSA- 0.00278459 2.55523931 67 84 5 10478 REAC Transcriptional regulation by RUNX1 REAC:R-HSA- 0.00282088 2.5496147 236 91 9 10478 REAC SIRT1 negatively regulates rRNA expression REAC:R-HSA- 0.00282088 2.5496147 68 84 5 10478 REAC Retinoid metabolism disease events REAC:R-HSA- 0.00373206 2.4280519 1 3 1 10478 REAC PRC2 methylates histones and DNA REAC:R-HSA- 0.00373206 2.4280519 73 84 5 10478 REAC Meiosis REAC:R-HSA- 0.00427976 2.36858083 117 84 6 10478 REAC ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression REAC:R-HSA- 0.00427976 2.36858083 76 84 5 10478 REAC Non-integrin membrane-ECM interactions REAC:R-HSA- 0.0052816 2.27723445 59 64 4 10478 REAC GRB2:SOS provides linkage to MAPK signaling for Integrins REAC:R-HSA- 0.0052816 2.27723445 14 24 2 10478 REAC Signaling by WNT REAC:R-HSA- 0.00584371 2.23331161 327 91 10 10478 REAC p130Cas linkage to MAPK signaling for integrins REAC:R-HSA- 0.00584371 2.23331161 15 24 2 10478 REAC MAPK family signaling cascades REAC:R-HSA- 0.00648183 2.1883025 274 91 9 10478 REAC Activation of anterior HOX genes in hindbrain development during early embryogenesis REAC:R-HSA- 0.00648183 2.1883025 122 90 6 10478 REAC Activation of HOX genes during differentiation REAC:R-HSA- 0.00648183 2.1883025 122 90 6 10478 REAC RNA Polymerase I Chain Elongation REAC:R-HSA- 0.00695278 2.15784133 89 84 5 10478 REAC B-WICH complex positively regulates rRNA expression REAC:R-HSA- 0.00695278 2.15784133 89 84 5 10478 REAC Mitotic Prophase REAC:R-HSA- 0.00695278 2.15784133 134 84 6 10478 REAC Cytokine Signaling in Immune system REAC:R-HSA- 0.00695278 2.15784133 676 64 12 10478 REAC Dissolution of Fibrin Clot REAC:R-HSA- 0.00696084 2.1573386 13 33 2 10478 REAC Packaging Of Telomere Ends REAC:R-HSA- 0.00722229 2.14132521 52 84 4 10478 REAC Elastic fibre formation REAC:R-HSA- 0.00885294 2.05291265 45 46 3 10478 REAC Reproduction REAC:R-HSA- 0.00885294 2.05291265 143 84 6 10478 REAC Cellular responses to stress REAC:R-HSA- 0.00897073 2.04717214 422 91 11 10478 REAC Degradation of the extracellular matrix REAC:R-HSA- 0.00897073 2.04717214 140 34 4 10478 REAC ECM proteoglycans REAC:R-HSA- 0.00993094 2.00300973 76 64 4 10478 REAC RMTs methylate histone arginines REAC:R-HSA- 0.01001507 1.99934598 79 62 4 10478 REAC Signaling by MET REAC:R-HSA- 0.01007993 1.99654246 77 64 4 10478 REAC Transcriptional regulation by small RNAs REAC:R-HSA- 0.01123403 1.94946436 103 84 5 10478 REAC Positive epigenetic regulation of rRNA expression REAC:R-HSA- 0.01153889 1.93783601 104 84 5 10478 REAC NoRC negatively regulates rRNA expression REAC:R-HSA- 0.01184941 1.92630315 105 84 5 10478 REAC Integrin alphaIIb beta3 signaling REAC:R-HSA- 0.01198548 1.92134457 26 24 2 10478 REAC Integrin signaling REAC:R-HSA- 0.01198548 1.92134457 26 24 2 10478 REAC Negative epigenetic regulation of rRNA expression REAC:R-HSA- 0.01262399 1.89880337 108 84 5 10478 REAC RNA Polymerase I Promoter Clearance REAC:R-HSA- 0.01262399 1.89880337 108 84 5 10478 REAC RNA Polymerase I Transcription REAC:R-HSA- 0.01348799 1.87005286 110 84 5 10478 REAC GP1b-IX-V activation signalling REAC:R-HSA- 0.01392964 1.85606016 11 64 2 10478 REAC Nonhomologous End-Joining (NHEJ) REAC:R-HSA- 0.01575138 1.80268145 69 84 4 10478 REAC Platelet degranulation REAC:R-HSA- 0.01917213 1.71732955 125 24 3 10478 REAC Diseases of REAC:R-HSA- 0.01917213 1.71732955 360 29 5 10478 REAC Cell surface interactions at the vascular wall REAC:R-HSA- 0.02010875 1.69661484 190 34 4 10478 REAC Signaling by high-kinase activity BRAF mutants REAC:R-HSA- 0.02010875 1.69661484 36 24 2 10478 REAC Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks REAC:R-HSA- 0.02010875 1.69661484 76 84 4 10478 REAC Ub-specific processing proteases REAC:R-HSA- 0.02010875 1.69661484 222 91 7 10478 REAC GPVI-mediated activation cascade REAC:R-HSA- 0.02010875 1.69661484 35 88 3 10478 REAC Response to elevated platelet cytosolic Ca2+ REAC:R-HSA- 0.02010875 1.69661484 130 24 3 10478 REAC Molecules associated with elastic fibres REAC:R-HSA- 0.02045865 1.689123 38 24 2 10478 REAC Meiotic synapsis REAC:R-HSA- 0.02045865 1.689123 77 84 4 10478 REAC DNA Double Strand Break Response REAC:R-HSA- 0.02045865 1.689123 77 84 4 10478 REAC Platelet Adhesion to exposed collagen REAC:R-HSA- 0.02083562 1.68119359 15 64 2 10478 REAC Paradoxical activation of RAF signaling by kinase inactive BRAF REAC:R-HSA- 0.02083562 1.68119359 40 24 2 10478 REAC Anchoring fibril formation REAC:R-HSA- 0.02083562 1.68119359 15 64 2 10478 REAC Retinoid cycle disease events REAC:R-HSA- 0.02083562 1.68119359 13 3 1 10478 REAC MAP2K and MAPK activation REAC:R-HSA- 0.02083562 1.68119359 40 24 2 10478 REAC Diseases associated with visual transduction REAC:R-HSA- 0.02083562 1.68119359 13 3 1 10478 REAC Signaling by moderate kinase activity BRAF mutants REAC:R-HSA- 0.02083562 1.68119359 40 24 2 10478 REAC DNA Damage/Telomere Stress Induced Senescence REAC:R-HSA- 0.02097076 1.67838585 80 84 4 10478 REAC Cellular responses to external stimuli REAC:R-HSA- 0.02097076 1.67838585 498 91 11 10478 REAC Telomere Maintenance REAC:R-HSA- 0.02266126 1.64471587 82 84 4 10478 REAC Gene Silencing by RNA REAC:R-HSA- 0.02269 1.6441656 133 84 5 10478 REAC Signaling by Receptor Kinases REAC:R-HSA- 0.02403806 1.61910064 439 50 7 10478 REAC Hemostasis REAC:R-HSA- 0.02641185 1.57820123 671 34 7 10478 REAC Chromatin modifying REAC:R-HSA- 0.02853146 1.54467595 275 62 6 10478 REAC Chromatin organization REAC:R-HSA- 0.02853146 1.54467595 275 62 6 10478 REAC Assembly of collagen fibrils and other multimeric structures REAC:R-HSA- 0.02950401 1.5301189 60 64 3 10478 REAC Scavenging by Class A Receptors REAC:R-HSA- 0.02954843 1.52946556 19 64 2 10478 REAC Epigenetic regulation of gene expression REAC:R-HSA- 0.03099143 1.50875835 146 84 5 10478 REAC The canonical retinoid cycle in rods (twilight vision) REAC:R-HSA- 0.03099143 1.50875835 22 3 1 10478 REAC Signaling by RAS mutants REAC:R-HSA- 0.03149556 1.50175066 53 24 2 10478 REAC G2/M DNA damage checkpoint REAC:R-HSA- 0.03402489 1.4682033 95 84 4 10478 REAC RAF-independent MAPK1/3 activation REAC:R-HSA- 0.03420102 1.4659609 22 61 2 10478 REAC MAPK6/MAPK4 signaling REAC:R-HSA- 0.03452341 1.46188634 89 91 4 10478 REAC Advanced glycosylation endproduct receptor signaling REAC:R-HSA- 0.03452341 1.46188634 13 6 1 10478 REAC Transcriptional regulation by RUNX3 REAC:R-HSA- 0.03452341 1.46188634 95 44 3 10478 REAC MAPK1 (ERK2) activation REAC:R-HSA- 0.03507269 1.45503098 8 10 1 10478 REAC Processing of DNA double-strand break ends REAC:R-HSA- 0.0358099 1.44599686 98 84 4 10478 REAC Signaling by BRAF and RAF fusions REAC:R-HSA- 0.03678472 1.4343326 60 24 2 10478 REAC Regulation of RUNX1 Expression and Activity REAC:R-HSA- 0.03678472 1.4343326 17 85 2 10478 REAC MAPK3 (ERK1) activation REAC:R-HSA- 0.03801858 1.42000413 9 10 1 10478 REAC Hyaluronan biosynthesis and export REAC:R-HSA- 0.03977239 1.40041831 5 19 1 10478 REAC Platelet activation, signaling and aggregation REAC:R-HSA- 0.04012401 1.39659566 257 34 4 10478 REAC G0 and Early G1 REAC:R-HSA- 0.04182653 1.37854815 27 58 2 10478 REAC Fibronectin matrix formation REAC:R-HSA- 0.04400811 1.35646726 6 18 1 10478 REAC Interleukin-6 signaling REAC:R-HSA- 0.0444261 1.35236186 11 10 1 10478 REAC Invadopodia formation REAC:R-HSA- 0.04486642 1.34807859 4 28 1 10478 REAC E3 ubiquitin ubiquitinate target proteins REAC:R-HSA- 0.04667154 1.33094783 58 84 3 10478 REAC Chromosome Maintenance REAC:R-HSA- 0.04685159 1.32927566 109 84 4 10478 REAC MAPK1/MAPK3 signaling REAC:R-HSA- 0.04795208 1.31919259 235 61 5 10478 Supplementary Table 4: Down-Regulated Pathways in Static Cold Storage Kidneys vs Non-Stored Kidneys source term_name term_id adjusted_p_value negative_log10_term_size query_size intersection_effective_domain_size REAC Metabolism REAC:R-HSA- 7.0865E-05 4.149568221 2041 164 60 10478 REAC Fatty acid metabolism REAC:R-HSA-8 7.0865E-05 4.149568221 173 160 14 10478 REAC SLC-mediated transmembrane transport REAC:R-HSA-4 0.000695222 3.157876376 243 88 11 10478 REAC Peroxisomal protein import REAC:R-HSA-9 0.000772756 3.111957513 60 129 7 10478 REAC Rhesus glycoproteins mediate ammonium transport. REAC:R-HSA-4 0.001340841 2.872622736 3 26 2 10478 REAC alpha-linolenic acid (ALA) metabolism REAC:R-HSA-2 0.001845804 2.733814334 12 58 3 10478 REAC alpha-linolenic (omega3) and linoleic (omega6) acid metabolism REAC:R-HSA-2 0.001845804 2.733814334 12 58 3 10478 REAC Metabolism of water-soluble vitamins and cofactors REAC:R-HSA- 0.00205577 2.687025404 120 146 9 10478 REAC Metabolism of vitamins and cofactors REAC:R-HSA- 0.002118498 2.673971937 186 146 11 10478 REAC Transport of small molecules REAC:R-HSA-3 0.002118498 2.673971937 716 111 20 10478 REAC Transport of bile salts and organic acids, metal ions and amine compounds REAC:R-HSA-4 0.002233288 2.651055229 86 167 8 10478 REAC Metabolism of amino acids and derivatives REAC:R-HSA-7 0.003317767 2.479154114 365 156 16 10478 REAC Peroxisomal lipid metabolism REAC:R-HSA-3 0.004372237 2.359296268 24 121 4 10478 REAC Na+/Cl- dependent neurotransmitter transporters REAC:R-HSA-4 0.005403593 2.267317336 19 167 4 10478 REAC Defects in vitamin and metabolism REAC:R-HSA-3 0.005411007 2.266721916 22 146 4 10478 REAC Mitochondrial Fatty Acid Beta-Oxidation REAC:R-HSA-7 0.005411007 2.266721916 37 160 5 10478 REAC Choline catabolism REAC:R-HSA-6 0.007651317 2.116263812 6 51 2 10478 REAC Metabolism of lipids REAC:R-HSA-5 0.007974377 2.098303227 726 164 24 10478 REAC TYSND1 cleaves peroxisomal proteins REAC:R-HSA-9 0.012359433 1.908001455 7 58 2 10478 REAC Abacavir transmembrane transport REAC:R-HSA-2 0.012965903 1.887197226 5 88 2 10478 REAC Passive transport by REAC:R-HSA-4 0.013584715 1.866949481 13 151 3 10478 REAC Metabolism of Angiotensinogen to Angiotensins REAC:R-HSA-2 0.013793919 1.860312341 17 116 3 10478 REAC Biosynthesis of DHA-derived SPMs REAC:R-HSA-9 0.014240977 1.846460225 16 29 2 10478 REAC Transport of inorganic cations/anions and amino acids/oligopeptides REAC:R-HSA-4 0.01536124 1.813573737 105 5 2 10478 REAC Biosynthesis of specialized proresolving mediators (SPMs) REAC:R-HSA-9 0.016647431 1.778652784 18 29 2 10478 REAC Sulfur metabolism REAC:R-HSA- 0.020803642 1.681860632 27 22 2 10478 REAC Abacavir transport and metabolism REAC:R-HSA-2 0.035482608 1.449984466 10 88 2 10478 REAC Organic cation transport REAC:R-HSA-5 0.035482608 1.449984466 10 88 2 10478 REAC Organic anion transporters REAC:R-HSA-4 0.035482608 1.449984466 10 3 1 10478 REAC Neurotransmitter clearance REAC:R-HSA- 0.035482608 1.449984466 10 88 2 10478 REAC Protein repair REAC:R-HSA-5 0.035482608 1.449984466 6 142 2 10478 REAC Defects in cobalamin (B12) metabolism REAC:R-HSA-3 0.035482608 1.449984466 14 57 2 10478 REAC Beta-oxidation of very long chain fatty acids REAC:R-HSA-3 0.040534324 1.392177064 8 121 2 10478 REAC Defective MTR causes methylmalonic aciduria and homocystinuria type cblG REAC:R-HSA-3 0.042655892 1.370020975 2 22 1 10478 REAC Defective HLCS causes multiple carboxylase deficiency REAC:R-HSA-3 0.042655892 1.370020975 7 146 2 10478 REAC Multifunctional anion exchangers REAC:R-HSA-4 0.042655892 1.370020975 9 5 1 10478 REAC Miscellaneous substrates REAC:R-HSA-2 0.042655892 1.370020975 12 84 2 10478 REAC Defective MTRR causes methylmalonic aciduria and homocystinuria type cblE REAC:R-HSA-3 0.042655892 1.370020975 2 22 1 10478 REAC Defective AVP does not bind AVPR1A,B and causes neurohypophyseal insipidus (NDI) REAC:R-HSA-5 0.044337182 1.353231915 3 16 1 10478 REAC Nicotinamide salvaging REAC:R-HSA- 0.047821127 1.320380194 19 3 1 10478 REAC Defects in biotin (Btn) metabolism REAC:R-HSA-3 0.047821127 1.320380194 8 146 2 10478 REAC Defective TCN2 causes hereditary megaloblastic anemia REAC:R-HSA-3 0.047821127 1.320380194 1 57 1 10478 REAC Post-translational REAC:R-HSA-8 0.047821127 1.320380194 107 110 5 10478 REAC Cobalamin (Cbl, vitamin B12) transport and metabolism REAC:R-HSA- 0.049087479 1.309029269 21 57 2 10478 Supplementary Table 5: Hallmark Enriched Pathways in Normothermic Ex Vivo Kidney Perfusion NAME SIZE ES NES NOM p-val FDR q-val FWER p-val RANK AT MAXLEADING EDGE HALLMARK_INTERFERON_GAMMA_RESPONSE 140 0.56701314 2.5501242 0 0 0 2796 tags=54%, list=20%, signal=66% HALLMARK_INTERFERON_ALPHA_RESPONSE 64 0.62832564 2.4787292 0 0 0 3512 tags=72%, list=25%, signal=95% HALLMARK_OXIDATIVE_PHOSPHORYLATION 145 0.4717907 2.145253 0 0 0 3806 tags=49%, list=27%, signal=66% HALLMARK_FATTY_ACID_METABOLISM 123 0.42626756 1.8620534 0 0.00267302 0.012 2893 tags=38%, list=21%, signal=48% HALLMARK_PEROXISOME 72 0.37904146 1.5309956 0.01367521 0.0573159 0.274 2884 tags=39%, list=20%, signal=49% HALLMARK_INFLAMMATORY_RESPONSE 152 0.31639493 1.450827 0.01010101 0.0906833 0.466 2758 tags=32%, list=20%, signal=39% HALLMARK_UV_RESPONSE_UP 123 0.319865 1.4238651 0.01178451 0.09741965 0.539 2389 tags=27%, list=17%, signal=32% HALLMARK_ADIPOGENESIS 146 0.30855918 1.4019644 0.01502504 0.10356353 0.597 3823 tags=43%, list=27%, signal=59% HALLMARK_KRAS_SIGNALING_UP 156 0.29771447 1.3543507 0.03344481 0.12124711 0.736 2712 tags=33%, list=19%, signal=40% HALLMARK_PROTEIN_SECRETION 79 0.33144048 1.3625835 0.04166667 0.12722556 0.715 4542 tags=49%, list=32%, signal=72% HALLMARK_ALLOGRAFT_REJECTION 150 0.29291296 1.3323451 0.04166667 0.13218963 0.802 2379 tags=26%, list=17%, signal=31% HALLMARK_IL6_JAK_STAT3_SIGNALING 64 0.3247773 1.3062915 0.09269162 0.14834185 0.863 2635 tags=34%, list=19%, signal=42% HALLMARK_TNFA_SIGNALING_VIA_NFKB 153 0.26412794 1.2094494 0.11092715 0.28194115 0.985 2513 tags=28%, list=18%, signal=34% HALLMARK_COMPLEMENT 145 0.26377353 1.182029 0.13809524 0.31557512 0.994 3019 tags=29%, list=21%, signal=36% HALLMARK_IL2_STAT5_SIGNALING 155 0.24823992 1.1367378 0.19250426 0.39281693 1 2090 tags=25%, list=15%, signal=28% HALLMARK_BILE_ACID_METABOLISM 81 0.26469162 1.0806701 0.31164384 0.5114514 1 2970 tags=28%, list=21%, signal=36% HALLMARK_P53_PATHWAY 148 0.23237477 1.0643481 0.31343284 0.5247486 1 2635 tags=28%, list=19%, signal=34% HALLMARK_CHOLESTEROL_HOMEOSTASIS 54 0.26734266 1.0252539 0.3905429 0.57459974 1 2251 tags=24%, list=16%, signal=29% HALLMARK_HYPOXIA 148 0.22920921 1.0328622 0.3697749 0.58338857 1 2655 tags=24%, list=19%, signal=30% HALLMARK_WNT_BETA_CATENIN_SIGNALING 32 0.27923712 0.95060074 0.5173611 0.7230797 1 2682 tags=25%, list=19%, signal=31% HALLMARK_UV_RESPONSE_DN 122 0.21883148 0.9605714 0.5426229 0.728743 1 2301 tags=20%, list=16%, signal=24% HALLMARK_KRAS_SIGNALING_DN 128 0.20588137 0.9186359 0.6360601 0.7777519 1 2717 tags=20%, list=19%, signal=24% HALLMARK_COAGULATION 102 0.20781407 0.8981952 0.6581197 0.7970872 1 1710 tags=17%, list=12%, signal=19% HALLMARK_HEME_METABOLISM 146 0.17528845 0.7887194 0.9186603 0.9575146 1 3042 tags=23%, list=22%, signal=29% HALLMARK_TGF_BETA_SIGNALING 40 0.22480837 0.8081906 0.78089887 0.96486723 1 2965 tags=28%, list=21%, signal=35% HALLMARK_PANCREAS_BETA_CELLS 34 0.20962965 0.72748685 0.882662 0.9872601 1 1596 tags=15%, list=11%, signal=17% HALLMARK_NOTCH_SIGNALING 20 0.2123574 0.6349522 0.94152045 0.9893704 1 4104 tags=45%, list=29%, signal=63% Supplementary Table 6: Hallmark Enriched Pathways in Static Cold Storage GS SIZE ES NES NOM p-val FDR q-val FWER p-val RANK AT MAXLEADING EDGE HALLMARK_G2M_CHECKPOINT 146 -0.5 -2.39 0 0 0 2526 tags=38%, list=18%, signal=45% HALLMARK_E2F_TARGETS 140 -0.5 -2.37 0 0 0 2976 tags=43%, list=21%, signal=54% HALLMARK_MITOTIC_SPINDLE 162 -0.42 -2.04 0 0 0 3218 tags=38%, list=23%, signal=49% HALLMARK_MYC_TARGETS_V1 158 -0.34 -1.64 0 0.017 0.073 3907 tags=37%, list=28%, signal=50% HALLMARK_MYC_TARGETS_V2 51 -0.42 -1.65 0.002 0.019 0.067 3462 tags=43%, list=25%, signal=57% HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAY 34 -0.44 -1.58 0.023 0.024 0.12 1427 tags=29%, list=10%, signal=33% HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION 165 -0.31 -1.5 0 0.036 0.206 2917 tags=33%, list=21%, signal=42% HALLMARK_ESTROGEN_RESPONSE_EARLY 159 -0.26 -1.26 0.075 0.216 0.83 1925 tags=21%, list=14%, signal=24% HALLMARK_SPERMATOGENESIS 105 -0.27 -1.24 0.105 0.221 0.87 1374 tags=14%, list=10%, signal=16% HALLMARK_ANGIOGENESIS 33 -0.36 -1.27 0.136 0.237 0.817 1128 tags=21%, list=8%, signal=23% HALLMARK_XENOBIOTIC_METABOLISM 152 -0.24 -1.16 0.148 0.288 0.972 1796 tags=16%, list=13%, signal=19% HALLMARK_MTORC1_SIGNALING 160 -0.24 -1.16 0.134 0.302 0.968 1406 tags=14%, list=10%, signal=15% HALLMARK_ANDROGEN_RESPONSE 80 -0.28 -1.19 0.155 0.305 0.953 3355 tags=35%, list=24%, signal=46% HALLMARK_APICAL_JUNCTION 157 -0.24 -1.17 0.136 0.309 0.965 2425 tags=22%, list=17%, signal=26% HALLMARK_ESTROGEN_RESPONSE_LATE 152 -0.23 -1.12 0.185 0.341 0.99 2213 tags=21%, list=16%, signal=25% HALLMARK_UNFOLDED_PROTEIN_RESPONSE 90 -0.25 -1.09 0.282 0.367 0.998 2736 tags=23%, list=19%, signal=29% HALLMARK_MYOGENESIS 152 -0.22 -1.09 0.228 0.389 0.998 893 tags=13%, list=6%, signal=13% HALLMARK_GLYCOLYSIS 152 -0.21 -1.03 0.392 0.497 1 1250 tags=14%, list=9%, signal=15% HALLMARK_HEDGEHOG_SIGNALING 30 -0.29 -1.01 0.447 0.522 1 3877 tags=53%, list=28%, signal=73% HALLMARK_APOPTOSIS 137 -0.2 -0.96 0.509 0.602 1 2315 tags=23%, list=16%, signal=28% HALLMARK_APICAL_SURFACE 38 -0.26 -0.96 0.496 0.618 1 2133 tags=26%, list=15%, signal=31% HALLMARK_DNA_REPAIR 99 -0.2 -0.92 0.628 0.671 1 2557 tags=19%, list=18%, signal=23% HALLMARK_PI3K_AKT_MTOR_SIGNALING 80 -0.18 -0.78 0.907 0.919 1 2951 tags=24%, list=21%, signal=30% Supplementary Table 7: Top 1000 Gene Set Enrichment Analysis Ranked Genes Gene Enriched In UBD NEVKP CDKL2 NEVKP CAMK1D NEVKP SLC28A2 NEVKP SARDH NEVKP RPS6KA6 NEVKP EGFLAM NEVKP SLC38A11 NEVKP SLC52A3 NEVKP CERS6 NEVKP UMOD NEVKP NDRG4 NEVKP CASQ2 NEVKP SLC15A2 NEVKP MPEG1 NEVKP RAB30 NEVKP LRCH2 NEVKP PROM1 NEVKP ADRA1B NEVKP SHISA2 NEVKP GALNT11 NEVKP RYR2 NEVKP ETNPPL NEVKP CLEC18C NEVKP CYP2D6 NEVKP KNG1 NEVKP ANKRD45 NEVKP SLC16A7 NEVKP KCNJ15 NEVKP LYRM7 NEVKP MTR NEVKP CLDN10 NEVKP CYP4V2 NEVKP BBS10 NEVKP EFCAB10 NEVKP POLR3H NEVKP LEAP2 NEVKP LRRC9 NEVKP DLK1 NEVKP ABCA9 NEVKP CLCNKA NEVKP MIOX NEVKP ZNF14 NEVKP CD38 NEVKP FBXO40 NEVKP GBP1 NEVKP FAM228B NEVKP GCNT4 NEVKP TXNIP NEVKP PGBD1 NEVKP CYP4F2 NEVKP CYP2B6 NEVKP ABCA6 NEVKP TMEM86A NEVKP RNU6-403P NEVKP BANK1 NEVKP SLC5A8 NEVKP CCDC113 NEVKP C1QB NEVKP RIMKLB NEVKP ART4 NEVKP SLC9A7 NEVKP PDE2A NEVKP STPG1 NEVKP ELOVL4 NEVKP IQCB1 NEVKP GCM1 NEVKP RAP1GAP2 NEVKP NCALD NEVKP PRKCQ NEVKP TMEM72 NEVKP SELENBP1 NEVKP MPP7 NEVKP AGMAT NEVKP TMEM116 NEVKP IL21R NEVKP TMEM213 NEVKP SLC12A1 NEVKP BPIFC NEVKP SLC6A18 NEVKP N4BP2L1 NEVKP UNC93A NEVKP C1QA NEVKP PCNX4 NEVKP SOWAHA NEVKP GLRX NEVKP FAM241A NEVKP ALDH1B1 NEVKP CRISPLD1 NEVKP GHR NEVKP CDS1 NEVKP NRK NEVKP CYSLTR1 NEVKP UGT2B15 NEVKP CHST9 NEVKP CNNM2 NEVKP ADGRE2 NEVKP CYP2A7 NEVKP DGAT2 NEVKP EPHA6 NEVKP CDKL1 NEVKP CDH18 NEVKP TBC1D32 NEVKP SFTPB NEVKP AADAT NEVKP OAT NEVKP PLN NEVKP DBP NEVKP TMEM267 NEVKP ANKRD1 NEVKP SNCAIP NEVKP SLC25A4 NEVKP C1QC NEVKP SERTM1 NEVKP FGL2 NEVKP LPCAT2 NEVKP SLC5A1 NEVKP VILL NEVKP GATM NEVKP ACACB NEVKP SHH NEVKP XK NEVKP B4GALT4 NEVKP STS NEVKP CARF NEVKP CYP2A6 NEVKP AP3M2 NEVKP CMAHP NEVKP PLCL1 NEVKP C17ORF75 NEVKP ZKSCAN8 NEVKP TNFRSF9 NEVKP LRRC66 NEVKP HOXD1 NEVKP PCDHB12 NEVKP GEM NEVKP FRMD3 NEVKP P2RY12 NEVKP OGN NEVKP ATL2 NEVKP GRAMD1C NEVKP ACADVL NEVKP SUSD4 NEVKP GCNT2 NEVKP MIR22 NEVKP RRM2B NEVKP CAPN6 NEVKP ADCY5 NEVKP ELMOD1 NEVKP BHMT NEVKP CD80 NEVKP ZNF286A NEVKP TRIM5 NEVKP SLC26A7 NEVKP HEY2 NEVKP TAF7 NEVKP ABCC6 NEVKP GPR183 NEVKP SETDB2 NEVKP STARD4 NEVKP PDZD2 NEVKP ACAD10 NEVKP CYP2A13 NEVKP ACOD1 NEVKP MPC2 NEVKP PIP4P2 NEVKP MIR186 NEVKP PER2 NEVKP C15ORF48 NEVKP STX11 NEVKP LYPD6 NEVKP GIMAP8 NEVKP ERBB4 NEVKP CXORF21 NEVKP C12ORF29 NEVKP TMEM17 NEVKP EPHA7 NEVKP SIDT1 NEVKP SMYD2 NEVKP HOMER1 NEVKP FCRL3 NEVKP SLC22A10 NEVKP GBP2 NEVKP MOSPD2 NEVKP PLA2G12A NEVKP GNG11 NEVKP AQP6 NEVKP CCL8 NEVKP C2ORF88 NEVKP ASAH1 NEVKP PPP1R16B NEVKP SLC7A13 NEVKP ARMCX3 NEVKP SIAE NEVKP NOX4 NEVKP TCP11L2 NEVKP PSAT1 NEVKP DEUP1 NEVKP GUCA2B NEVKP ECM2 NEVKP ZNF569 NEVKP FAM83B NEVKP VEGFD NEVKP PANK1 NEVKP CHAC2 NEVKP SLC38A6 NEVKP CPB2 NEVKP EPB41L4B NEVKP EXTL2 NEVKP RRAGD NEVKP PDCD4 NEVKP APC NEVKP SLC25A45 NEVKP TRIM36 NEVKP TMEM47 NEVKP STXBP6 NEVKP VPS25 NEVKP MSRB2 NEVKP PDE4B NEVKP TBCC NEVKP ZFAND4 NEVKP OCA2 NEVKP OR6N2 NEVKP SIM1 NEVKP SGPP2 NEVKP TLR1 NEVKP SAMD15 NEVKP CXCL10 NEVKP CMTM6 NEVKP ENO3 NEVKP LRRC39 NEVKP CPEB3 NEVKP TRAPPC6B NEVKP GALNT14 NEVKP PLCB4 NEVKP BBS7 NEVKP CALB1 NEVKP CCDC3 NEVKP WDR35 NEVKP CCL28 NEVKP BBS4 NEVKP GJC1 NEVKP SGCE NEVKP TTC26 NEVKP TM7SF3 NEVKP ITM2A NEVKP DHRS7 NEVKP RNF144B NEVKP DMRTA1 NEVKP ADAM22 NEVKP BBS5 NEVKP DYNC2LI1 NEVKP OXCT1 NEVKP HMCN1 NEVKP PPP1R1A NEVKP ZNF705A NEVKP ARMCX2 NEVKP TMEM229B NEVKP SCAMP1 NEVKP DMGDH NEVKP DIXDC1 NEVKP CNTN4 NEVKP TMEM128 NEVKP AQP7 NEVKP ANGPT1 NEVKP ADGB NEVKP CRYZL1 NEVKP ARHGEF18 NEVKP P2RY14 NEVKP FGL1 NEVKP Mar-08 NEVKP IFT80 NEVKP MIR296 NEVKP KLRF1 NEVKP RERG NEVKP CDKL5 NEVKP EVA1A NEVKP GTPBP8 NEVKP SLC2A12 NEVKP TMEM100 NEVKP CISD1 NEVKP FAM169A NEVKP ST3GAL6 NEVKP ACTG1 NEVKP FANK1 NEVKP EPHA4 NEVKP ASB13 NEVKP MITF NEVKP MANBA NEVKP CXCL12 NEVKP AKT3 NEVKP PRCP NEVKP IFT81 NEVKP LAIR1 NEVKP RFTN2 NEVKP SERINC1 NEVKP ALX1 NEVKP GGACT NEVKP CD2 NEVKP PROX1 NEVKP WNT11 NEVKP CASR NEVKP TLCD1 NEVKP MSRB3 NEVKP APOD NEVKP HPSE NEVKP VSIG4 NEVKP ATG4A NEVKP BVES NEVKP FGFR2 NEVKP ZNF570 NEVKP JAZF1 NEVKP ZNF391 NEVKP LCA5 NEVKP RDH5 NEVKP SLC38A9 NEVKP RAB37 NEVKP PDILT NEVKP KIF3A NEVKP CXCL9 NEVKP FRK NEVKP SLC15A3 NEVKP PSMB9 NEVKP CDH13 NEVKP CCL11 NEVKP FBXO48 NEVKP SFT2D2 NEVKP MIGA1 NEVKP TRHDE NEVKP GALNTL5 NEVKP GDF9 NEVKP PPARA NEVKP RNU6-157P NEVKP VWA2 NEVKP C4ORF47 NEVKP MFRP NEVKP MNDA NEVKP MANSC4 NEVKP STYK1 NEVKP IYD NEVKP F9 NEVKP BORCS7 NEVKP RFX6 NEVKP ACSL3 NEVKP LAYN NEVKP HSD11B2 NEVKP C8ORF34 NEVKP GVINP1 NEVKP PTN NEVKP SLC13A2 NEVKP PKIA NEVKP PSTPIP2 NEVKP MTERF2 NEVKP ZNF404 NEVKP NNAT NEVKP RAB27B NEVKP CTHRC1 NEVKP SLC30A9 NEVKP OR2C3 NEVKP AKR1D1 NEVKP GPR88 NEVKP FXYD6 NEVKP CD180 NEVKP ZFP30 NEVKP TRMT9B NEVKP GPALPP1 NEVKP EID1 NEVKP FAM151B NEVKP APOC3 NEVKP FRZB NEVKP ZNF200 NEVKP RAB4A NEVKP TMBIM4 NEVKP GPR1 NEVKP AOC3 NEVKP CPED1 NEVKP CYLD NEVKP CHN2 NEVKP BAZ1B NEVKP CRBN NEVKP ERAP2 NEVKP OR51E2 NEVKP UPRT NEVKP HRG NEVKP TCTN1 NEVKP ZNF300 NEVKP POT1 NEVKP LRP12 NEVKP SEMA3D NEVKP ZNF25 NEVKP FGF12 NEVKP CARNMT1 NEVKP FAM13C NEVKP PTPRC NEVKP RNU6-7 NEVKP DHRS4 NEVKP MSRA NEVKP SPAG16 NEVKP GLB1L2 NEVKP CAMK2D NEVKP MNS1 NEVKP SLC9A6 NEVKP NAPEPLD NEVKP TRAF6 NEVKP PRRT1 NEVKP UST NEVKP TMEM206 NEVKP VSIG1 NEVKP CASD1 NEVKP ITK NEVKP GM2A NEVKP IGFBP3 NEVKP SLAMF7 NEVKP INPP5F NEVKP ZC2HC1A NEVKP RGS18 NEVKP TCF4 NEVKP REEP1 NEVKP OR4F4 NEVKP STC1 NEVKP MFSD9 NEVKP GP2 NEVKP SLC5A10 NEVKP ANGPT2 NEVKP ZNF667 NEVKP ATP1B1 NEVKP LYPD6B NEVKP A1CF NEVKP SLC16A4 NEVKP BMP4 NEVKP SYT11 NEVKP RASGRF2 NEVKP USP2 NEVKP TSPAN1 NEVKP TOMM20 NEVKP NRSN2 NEVKP TMEM136 NEVKP SCP2 NEVKP KBTBD6 NEVKP GNLY NEVKP C15ORF61 NEVKP IFIT1 NEVKP EGFL8 NEVKP CLRN1 NEVKP SYNPO2 NEVKP RTL4 NEVKP C1ORF141 NEVKP SYPL1 NEVKP CD86 NEVKP C22ORF23 NEVKP RECK NEVKP PARP2 NEVKP CCDC91 NEVKP CABCOCO1 NEVKP NIPAL4 NEVKP TMEM161B NEVKP HSF2 NEVKP ARHGAP24 NEVKP LRRC49 NEVKP RGL3 NEVKP CALHM5 NEVKP LRRIQ1 NEVKP ACE2 NEVKP PDZRN3 NEVKP APH1B NEVKP KCNJ1 NEVKP SLC16A6 NEVKP DAO NEVKP MECOM NEVKP POLI NEVKP GRAMD2B NEVKP ANGPTL1 NEVKP PEBP4 NEVKP CCDC150 NEVKP CYP2U1 NEVKP AFAP1L2 NEVKP NT5DC1 NEVKP TWSG1 NEVKP HSPA12A NEVKP CLEC2B NEVKP TMEM260 NEVKP UNC5D NEVKP GRIP1 NEVKP CDKL3 NEVKP ANKRD42 NEVKP MS4A6A NEVKP MIR105-1 NEVKP ACAA1 NEVKP IFIH1 NEVKP TMEM262 NEVKP RPGRIP1L NEVKP DNAJB4 NEVKP MFSD4A NEVKP GPR137B NEVKP CRIPT NEVKP GCNT3 NEVKP TLR8 NEVKP AGA NEVKP ANGEL1 NEVKP KCND3 NEVKP DERL3 SCS TRIM6 SCS AGO2 SCS GLIS3 SCS ELL3 SCS RNU6-1048P SCS NUF2 SCS TFPT SCS NEK2 SCS CKS1B SCS RCN1 SCS CLN6 SCS ANKRD52 SCS MICAL2 SCS HIST1H1C SCS ZNF48 SCS ZIC5 SCS NHS SCS LARGE1 SCS NPS SCS PSMD3 SCS ARHGEF10L SCS MAK SCS ANXA2 SCS FAM84B SCS NFAM1 SCS TCTE1 SCS SNORA52 SCS HMGB2 SCS CDCA5 SCS MCM4 SCS CADM4 SCS PIF1 SCS GLRA2 SCS WDR81 SCS PRKX SCS SLC5A5 SCS TTK SCS CLPS SCS LRRC74B SCS MAGEA10 SCS KLF9 SCS CATSPER2 SCS RAD51AP1 SCS RPL8 SCS PDIA6 SCS PRDX4 SCS MYC SCS ABCC9 SCS TTC16 SCS CCSAP SCS AP1B1 SCS TRERF1 SCS BUB1B SCS RPL36 SCS BNIPL SCS OR2G3 SCS OR56A1 SCS PAX3 SCS RPS19 SCS OR51I1 SCS RNU6-916P SCS OR2B11 SCS FAM83A SCS BPIFB1 SCS SLAMF6 SCS SCN8A SCS SLC29A4 SCS MYH9 SCS TUBB4A SCS POU3F1 SCS CNTRL SCS ADAMTS9 SCS PRR18 SCS NPY6R SCS RNU6-284P SCS DACH1 SCS UHRF1BP1 SCS OR1A1 SCS AHNAK SCS LTBP2 SCS SMPD3 SCS RPRML SCS RUNX1 SCS UGT1A6 SCS SNORA33 SCS MAML3 SCS FABP7 SCS CFAP47 SCS MSC SCS AKIRIN2 SCS CAPG SCS AP2S1 SCS ANO6 SCS YIF1B SCS CENPO SCS TG SCS CEACAM16 SCS CLPTM1L SCS C17ORF53 SCS SLC45A1 SCS NUP62 SCS HAS1 SCS SERPINF2 SCS AMOT SCS ORM1 SCS RGS20 SCS MIR185 SCS OR14J1 SCS MIR129-1 SCS SNORA80E SCS NOS1AP SCS ZIC3 SCS DCBLD2 SCS TLX2 SCS TOP2A SCS THBS2 SCS ANKRD23 SCS UBQLN4 SCS NOS1 SCS OR52E2 SCS CDCA3 SCS SYTL1 SCS TM4SF5 SCS RBPMS2 SCS TMEM258 SCS HCFC1 SCS RNU6-460P SCS AK4 SCS PIK3AP1 SCS RNU6-20P SCS SNORD50B SCS GGT1 SCS TMCO5B SCS PWP1 SCS LYPD1 SCS SCARB1 SCS HYOU1 SCS S100A9 SCS ABCA12 SCS KRT34 SCS DDX54 SCS PDSS1 SCS SCEL SCS HIST1H2BK SCS CDH2 SCS HTATIP2 SCS CHRNA3 SCS VAV2 SCS NEURL4 SCS SOAT2 SCS SNORD100 SCS TM4SF4 SCS CORO1B SCS CPO SCS MAPK8IP1 SCS KIAA0513 SCS FLAD1 SCS MIR135A1 SCS AGAP1 SCS EPB41 SCS SNORD19B SCS IQGAP3 SCS RPL36A SCS COL4A2 SCS MVK SCS RNU6-1044P SCS SGO1 SCS HIST2H2AA3 SCS URB2 SCS SNORD101 SCS TUBB1 SCS CCNB2 SCS TMPRSS2 SCS IMPDH1 SCS DZIP3 SCS EFHD2 SCS OR10AG1 SCS MYRF SCS CARMIL1 SCS MYL4 SCS OR4Q2 SCS OR4F3 SCS NR2E1 SCS WDR5 SCS PHLDA1 SCS TENT5D SCS COX8BP SCS MIDN SCS PAQR8 SCS SAA3P SCS MUC13 SCS NAV2 SCS NFRKB SCS COL6A3 SCS SDF2L1 SCS SKOR2 SCS KRTAP4-12 SCS ZIC2 SCS FAM83F SCS TEAD4 SCS CCNO SCS PPL SCS ETV1 SCS OR5AN1 SCS LYRM4 SCS RNU5A-1 SCS ANXA2R SCS TFAP2A SCS DRAP1 SCS FOXM1 SCS C1ORF158 SCS DSC2 SCS CKAP2L SCS CRLF1 SCS SIL1 SCS PRKRIP1 SCS TRAV13-1 SCS RNU1-44P SCS GSR SCS UPK3BL2 SCS WWC1 SCS PABPC4 SCS TOR2A SCS FLT1 SCS MYBL1 SCS PBX4 SCS FSCN1 SCS CIC SCS NEIL3 SCS HES3 SCS MIR30D SCS RPS29 SCS DLK2 SCS SNORD4A SCS PPP1R14B SCS C11ORF87 SCS XYLT1 SCS TUBA1C SCS CCNB3 SCS MFGE8 SCS MTHFD1L SCS CENPF SCS URAD SCS TAS2R10 SCS COL4A1 SCS PKDCC SCS BAG3 SCS DDX39A SCS SEMA5B SCS CCDC185 SCS TMEM173 SCS RNU6-1298P SCS MIRLET7I SCS GNAO1 SCS TEX37 SCS FGF23 SCS TMEM63C SCS NTRK2 SCS RNU6-792P SCS CEP55 SCS ARAP2 SCS KIF23 SCS NR1I3 SCS CENPV SCS OSR2 SCS HP SCS RNU6-804P SCS RORB SCS CCDC190 SCS IKBKG SCS RNU6-211P SCS OR5P3 SCS PLEK2 SCS ABCC3 SCS ZCCHC18 SCS HIST1H3B SCS FAM72A SCS COG7 SCS NCAPD2 SCS TRPV5 SCS IZUMO4 SCS TEX14 SCS MRTO4 SCS DLGAP5 SCS HIST1H3A SCS HIST1H3C SCS DNMT3B SCS C2ORF40 SCS GCHFR SCS RNU6-715P SCS CINP SCS C5 SCS TLE3 SCS DACT2 SCS MSX1 SCS BMX SCS MIR708 SCS OR4K1 SCS CERCAM SCS DOHH SCS PCDHB4 SCS SNORA17B SCS KIFC1 SCS FGB SCS NKX2-4 SCS CAVIN3 SCS TFE3 SCS RAB3B SCS PILRA SCS KCNE3 SCS KRT15 SCS FSTL4 SCS RBFOX1 SCS HCRTR2 SCS CPLX3 SCS MSGN1 SCS ALOX12 SCS TACC3 SCS POLD1 SCS FGF20 SCS MLKL SCS HTR3D SCS COL17A1 SCS MDGA1 SCS CDK2AP2 SCS KIF4A SCS HECW2 SCS STIL SCS FLNC SCS SLC1A5 SCS POMC SCS TNFSF4 SCS TEN1 SCS PTTG1 SCS ELAC2 SCS UCHL1 SCS AKR1C8P SCS GPR52 SCS FAM20A SCS RPL32 SCS GRAMD1B SCS RACGAP1 SCS PITPNC1 SCS TRAV10 SCS OR9I1 SCS BACH2 SCS M1AP SCS ASPM SCS SLC29A1 SCS EPHA2 SCS ADAM12 SCS FYB2 SCS NQO1 SCS TRIM8 SCS NT5C SCS WASF1 SCS C6ORF141 SCS CENPA SCS ADGRG1 SCS HOXB7 SCS SNORD1C SCS ITIH2 SCS FOXH1 SCS LGALS1 SCS PRPH SCS GSTO1 SCS RNU6-191P SCS TEX45 SCS STX3 SCS CPXM1 SCS RNU6-313P SCS ZPLD1 SCS CDKN3 SCS PCDH7 SCS OR13C2 SCS MIR146B SCS GLI4 SCS ASGR1 SCS TMCC2 SCS TXNRD1 SCS OR4K3 SCS EMX2 SCS KNTC1 SCS CDC20 SCS TMEM89 SCS MAP4K4 SCS LY96 SCS GRM3 SCS CYP27A1 SCS SNORD6 SCS MIR98 SCS HIST1H2BN SCS UBALD2 SCS PGPEP1L SCS KIF20A SCS ANLN SCS IL4R SCS SKA1 SCS ETV4 SCS TALDO1 SCS CDKN1A SCS GALNT10 SCS DUSP4 SCS HIST2H3A SCS CKS2 SCS SFN SCS HIST3H3 SCS PRSS1 SCS SLC26A6 SCS AATF SCS ELMSAN1 SCS PRDX1 SCS UQCR10 SCS AMIGO3 SCS CDH6 SCS RLN2 SCS KIF2C SCS TAS2R9 SCS UBE2C SCS EPS8L2 SCS FZD5 SCS ITPR3 SCS STOX1 SCS ADRA2A SCS SPRY3 SCS TPX2 SCS NFIL3 SCS AFP SCS ANOS1 SCS SNORD73B SCS IFNK SCS POLR1D SCS CCDC84 SCS PLEKHS1 SCS SNORD121A SCS ZFAND2A SCS OR4F15 SCS GCLC SCS ZYX SCS RHOC SCS RPSA SCS SLC17A3 SCS FAM83D SCS KRT36 SCS CD44 SCS DCDC2 SCS SLC39A14 SCS ZNF662 SCS KIF14 SCS NKAIN1 SCS FOSL1 SCS S100A12 SCS GSTA1 SCS FN1 SCS OR10G2 SCS PIR SCS LRP8 SCS ESPL1 SCS KLF5 SCS CRTAC1 SCS SEMA6A SCS CHI3L1 SCS ST3GAL1 SCS MXRA5 SCS CCDC167 SCS RNU6-1328P SCS EN2 SCS OR2D3 SCS HMGA1 SCS CEACAM1 SCS MYBL2 SCS OR51F1 SCS LRG1 SCS SCUBE3 SCS TNFRSF21 SCS HIST1H4I SCS ANXA13 SCS UNC5CL SCS COL14A1 SCS SCGN SCS S100A2 SCS ABHD4 SCS SRXN1 SCS LOXL4 SCS PGD SCS PLAU SCS ARG2 SCS AURKA SCS HHIPL1 SCS CYP24A1 SCS PTGR1 SCS KRT18 SCS NRG1 SCS SACS SCS HSPB8 SCS ITGA3 SCS REG3G SCS RNF39 SCS RBP4 SCS Supplementary Table 8: Normothermic Ex Vivo Kindey Perfusion Enriched Terms and Pathways NAME Details Reference Enrichment Score NES FDR q-val HALLMARK_INTERFERON_GAMMA_RESPONSE MSIGDB_C2 HALLMARK_INTERFERON_G 0.5653831 2.5532622 0 HALLMARK_INTERFERON_ALPHA_RESPONSE MSIGDB_C2 HALLMARK_INTERFERON_A 0.62459034 2.4575353 0 CILIARY TRANSITION ZONE GOCC GO:0035869 0.6313396 2.2672958 0.00130811 FATTY ACID BETA-OXIDATION GOBP GO:0006635 0.6090519 2.2585785 0.00147279 XENOBIOTICS REACTOME R-HSA-211981.1 0.78708357 2.2289796 0.00196473 PYRUVATE METABOLISM AND CITRIC ACID (TCA) CYCLE REACTOME DATAB 71406 0.6056955 2.2156014 0.00245173 MITOCHONDRIAL LC-FATTY ACID BETA-OXIDATION WIKIPATHWAYS_20WP368 0.7713416 2.196584 0.00320751 FATTY ACID OXIDATION GOBP GO:0019395 0.57119465 2.175284 0.00391096 LIPID OXIDATION GOBP GO:0034440 0.5782694 2.1677265 0.00400503 ARACHIDONIC ACID METABOLIC PROCESS GOBP GO:0019369 0.61497676 2.183004 0.00415289 TYPE II INTERFERON SIGNALING (IFNG) WIKIPATHWAYS_20WP619 0.6757673 2.1575992 0.00470536 FATTY ACID CATABOLIC PROCESS GOBP GO:0009062 0.53169745 2.1544812 0.00472153 FATTY ACID BETA OXIDATION WIKIPATHWAYS_20WP143 0.64751893 2.1486487 0.00473161 MONOCARBOXYLIC ACID CATABOLIC PROCESS GOBP GO:0072329 0.5182597 2.1406355 0.00488136 ACTIVITY, ACTING ON THE CH-CH GROUP OF DONORS GOMF GO:0016627 0.6279596 2.1334636 0.00494678 LIPID MODIFICATION GOBP GO:0030258 0.48721015 2.126766 0.0050656 HALLMARK_OXIDATIVE_PHOSPHORYLATION MSIGDB_C2 HALLMARK_OXIDATIVE_PH 0.46938047 2.1189053 0.00553641 BBSOME-MEDIATED CARGO-TARGETING TO REACTOME DATAB 5620922 0.7360434 2.119509 0.00574648 LYMPHOCYTE CHEMOTAXIS GOBP GO:0048247 0.61533284 2.0894856 0.00828092 ATPASE BINDING GOMF GO:0051117 0.55999905 2.0589566 0.01334255 AMINO ACID SYNTHESIS AND INTERCONVERSION (TRANSAMINATION) REACTOME R-HSA-70614.5 0.6513885 2.0447729 0.01559613 FATTY ACID METABOLIC PROCESS GOBP GO:0006631 0.43366125 2.0178773 0.02221745 RESPONSE TO CHEMOKINE GOBP GO:1990868 0.5519133 1.9854496 0.03133661 ORGANIC ACID TRANSMEMBRANE TRANSPORT GOBP GO:1903825 0.52342373 1.9872527 0.03166377 CARBOXYLIC ACID TRANSMEMBRANE TRANSPORT GOBP GO:1905039 0.52342373 1.9901979 0.03185194 MONOCARBOXYLIC ACID METABOLIC PROCESS GOBP GO:0032787 0.39628017 1.9538544 0.0455075 REGULATION OF CARDIAC MUSCLE CELL DIFFERENTIATION GOBP GO:2000725 0.6885465 1.9448081 0.04592516 CELLULAR LIPID CATABOLIC PROCESS GOBP GO:0044242 0.44226512 1.9371476 0.04632426 CELLULAR RESPONSE TO CHEMOKINE GOBP GO:1990869 0.5519133 1.9480841 0.04700713 EXOGENOUS DRUG CATABOLIC PROCESS GOBP GO:0042738 0.6802843 1.9459056 0.04703917 CHEMOKINE RECEPTOR BINDING GOMF GO:0042379 0.56197363 1.9374369 0.04756612 CHEMOKINE ACTIVITY GOMF GO:0008009 0.5776649 1.9385042 0.04820595 GRANULOCYTE MIGRATION GOBP GO:0097530 0.5200099 1.931326 0.04865457 CHEMOKINE-MEDIATED SIGNALING PATHWAY GOBP GO:0070098 0.5413518 1.9235573 0.049986 PYRUVATE METABOLISM REACTOME DATAB 70268 0.62925667 1.9247267 0.05046262 Supplementary Table 9: Static Cold Storage Enriched Gene Ontology Terms and Pathways NAME Details Reference Enrichment Score NES FDR q-val PRE-NOTCH TRANSCRIPTION AND TRANSLATION REACTOME R-HSA-19124 -0.670546 -2.6762295 0 RNA POLYMERASE I PROMOTER OPENING REACTOME DATA 73728 -0.7931243 -2.6037865 0 CHROMATIN ASSEMBLY GOBP GO:0031497 -0.60707 -2.578906 0 EUKARYOTIC TRANSLATION ELONGATION REACTOME R-HSA-15684 -0.6053681 -2.5537827 0 FORMATION OF THE BETA-CATENIN:TCF TRANSACTIVATING COMPLEX REACTOME DATA 201722 -0.6336696 -2.5510187 0 PRC2 METHYLATES HISTONES AND DNA REACTOME DATA 212300 -0.7111119 -2.5506067 0 DNA METHYLATION REACTOME R-HSA-53341 -0.75622964 -2.533127 0 CONDENSATION OF PROPHASE CHROMOSOMES REACTOME DATA2299718 -0.7149397 -2.5167806 0 PEPTIDE CHAIN ELONGATION REACTOME R-HSA-15690 -0.6062622 -2.5135775 0 VIRAL MRNA TRANSLATION REACTOME DATA 192823 -0.59972817 -2.5019479 0 NONSENSE MEDIATED DECAY (NMD) INDEPENDENT OF THE JUNCTION COMPLEX (EJC) REACTOME R-HSA-97595 -0.5852244 -2.4963946 0 DNA PACKAGING GOBP GO:0006323 -0.5427541 -2.4850655 0 DEPOSITION OF NEW CENPA-CONTAINING NUCLEOSOMES AT THE CENTROMERE REACTOME DATA 606279 -0.6890603 -2.4823754 0 MEIOTIC RECOMBINATION REACTOME DATA 912446 -0.6206817 -2.3533323 2.76E-05 MICROTUBULE CYTOSKELETON ORGANIZATION INVOLVED IN MITOSIS GOBP GO:1902850 -0.57462347 -2.353588 2.84E-05 NUCLEOSOME ORGANIZATION GOBP GO:0034728 -0.52882504 -2.3579724 2.92E-05 NUCLEAR-TRANSCRIBED MRNA CATABOLIC PROCESS, NONSENSE-MEDIATED DECAY GOBP GO:0000184 -0.54828554 -2.361171 3.00E-05 TRANSLATIONAL INITIATION GOBP GO:0006413 -0.5303356 -2.363793 3.09E-05 HALLMARK_E2F_TARGETS MSIGDB_C2 HALLMARK_E -0.5039726 -2.3701398 3.18E-05 SISTER CHROMATID SEGREGATION GOBP GO:0000819 -0.53065014 -2.3762145 3.28E-05 SIRT1 NEGATIVELY REGULATES RRNA EXPRESSION REACTOME R-HSA-42735 -0.7122902 -2.3825405 3.39E-05 NUCLEOSOME ASSEMBLY GOBP GO:0006334 -0.5968919 -2.386072 3.50E-05 MITOTIC SISTER CHROMATID SEGREGATION GOBP GO:0000070 -0.57752085 -2.3882446 3.62E-05 CAP-DEPENDENT TRANSLATION INITIATION REACTOME R-HSA-72737 -0.5481008 -2.3883266 3.75E-05 EUKARYOTIC TRANSLATION INITIATION REACTOME R-HSA-72613 -0.5481008 -2.391652 3.89E-05 INFLUENZA VIRAL RNA TRANSCRIPTION AND REPLICATION REACTOME DATA 168273 -0.5390698 -2.394229 4.04E-05 DNA PACKAGING COMPLEX GOCC GO:0044815 -0.69594145 -2.3983736 4.20E-05 HALLMARK_G2M_CHECKPOINT MSIGDB_C2 HALLMARK_G -0.49756268 -2.4075103 4.38E-05 L13A-MEDIATED TRANSLATIONAL SILENCING OF CERULOPLASMIN EXPRESSION REACTOME R-HSA-15682 -0.55553097 -2.4099984 4.57E-05 GTP HYDROLYSIS AND JOINING OF THE 60S RIBOSOMAL SUBUNIT REACTOME R-HSA-72706 -0.553199 -2.4167747 4.77E-05 INFLUENZA LIFE CYCLE REACTOME DATA 168255 -0.5450602 -2.4315195 5.00E-05 PRE-NOTCH EXPRESSION AND PROCESSING REACTOME R-HSA-19124 -0.5942476 -2.4364102 5.25E-05 CHROMOSOME MAINTENANCE REACTOME DATA 73886 -0.5629072 -2.3403583 5.32E-05 CHROMATIN ASSEMBLY OR DISASSEMBLY GOBP GO:0006333 -0.5478913 -2.4524155 5.53E-05 EUKARYOTIC TRANSLATION TERMINATION REACTOME R-HSA-72764 -0.584414 -2.4546492 5.83E-05 SELENOCYSTEINE SYNTHESIS REACTOME R-HSA-24085 -0.58754474 -2.4553232 6.18E-05 ACTIVATED PKN1 STIMULATES TRANSCRIPTION OF AR (ANDROGEN RECEPTOR) REGULATED GENREACTOME DATA 5625886 -0.7278004 -2.4589312 6.56E-05 FORMATION OF A POOL OF FREE 40S SUBUNITS REACTOME DATA 72689 -0.57323754 -2.4607327 7.00E-05 NUCLEOSOME ASSEMBLY REACTOME R-HSA-77481 -0.6890603 -2.4613764 7.50E-05 MITOTIC NUCLEAR DIVISION GOBP GO:0140014 -0.52720314 -2.3332088 7.74E-05 NONSENSE MEDIATED DECAY (NMD) ENHANCED BY THE EXON JUNCTION COMPLEX (EJC) REACTOME DATA 975957 -0.53181016 -2.3094418 8.63E-05 COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE GOBP GO:0006613 -0.54852355 -2.310537 8.82E-05 NONSENSE-MEDIATED DECAY (NMD) REACTOME DATA 927802 -0.53181016 -2.3142967 9.01E-05 VIRAL GENE EXPRESSION GOBP GO:0019080 -0.52002543 -2.3149645 9.21E-05 RHO GTPASES ACTIVATE PKNS REACTOME R-HSA-56257 -0.5933056 -2.3151343 9.42E-05 VIRAL TRANSCRIPTION GOBP GO:0019083 -0.5324336 -2.316914 9.64E-05 INFLUENZA INFECTION REACTOME DATA 168254 -0.5126283 -2.319906 9.87E-05 NUCLEOSOME GOCC GO:0000786 -0.71654063 -2.325819 1.01E-04 SRP-DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE REACTOME DATA1799339 -0.51889145 -2.3041627 1.04E-04 CYTOPLASMIC RIBOSOMAL PROTEINS WIKIPATHWAYS_WP477 -0.5578886 -2.3063416 1.06E-04 SRP-DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE GOBP GO:0006614 -0.5590731 -2.2924929 1.41E-04 STRUCTURAL CONSTITUENT OF RIBOSOME GOMF GO:0003735 -0.51076376 -2.2884629 1.58E-04 SENESCENCE-ASSOCIATED SECRETORY PHENOTYPE (SASP) REACTOME R-HSA-25595 -0.5575135 -2.2770455 1.75E-04 TRANSCRIPTIONAL REGULATION BY SMALL RNAS REACTOME R-HSA-55787 -0.5803884 -2.272907 2.10E-04 ACTIVATION OF RRNA EXPRESSION BY ERCC6 (CSB) AND EHMT2 (G9A) REACTOME DATA 427389 -0.6169919 -2.2382967 3.00E-04 SELENOAMINO ACID METABOLISM REACTOME R-HSA-24085 -0.5162386 -2.2363784 3.13E-04 PROTEIN TARGETING TO ER GOBP GO:0045047 -0.5184208 -2.2333753 3.62E-04 CYTOPLASMIC TRANSLATION GOBP GO:0002181 -0.60302126 -2.2299259 3.73E-04 B-WICH COMPLEX POSITIVELY REGULATES RRNA EXPRESSION REACTOME R-HSA-52509 -0.575028 -2.2258046 3.84E-04 GENE SILENCING BY RNA REACTOME DATA 211000 -0.51912034 -2.2107778 5.40E-04 CONDENSED CHROMOSOME, CENTROMERIC REGION GOCC GO:0000779 -0.6762523 -2.2030096 5.48E-04 NUCLEAR CHROMOSOME SEGREGATION GOBP GO:0098813 -0.4778539 -2.2110906 5.49E-04 CENTROMERE COMPLEX ASSEMBLY GOBP GO:0034508 -0.6624664 -2.1909828 6.86E-04 RUNX1 REGULATES GENES INVOLVED IN MEGAKARYOCYTE DIFFERENTIATION AND PLATELET FUNREACTOME R-HSA-89364 -0.555139 -2.1845078 7.37E-04 RRNA PROCESSING IN THE NUCLEUS AND CYTOSOL REACTOME R-HSA-88687 -0.4623863 -2.1873493 7.44E-04 MIRNA TARGETS IN ECM AND MEMBRANE RECEPTORS WIKIPATHWAYS_WP2911 -0.63689333 -2.1855142 7.49E-04 NUCLEAR DIVISION GOBP GO:0000280 -0.45432767 -2.1873536 7.56E-04 ACTIVATION OF ANTERIOR HOX GENES IN HINDBRAIN DEVELOPMENT DURING EARLY EMBRYOG REACTOME DATA5617472 -0.5286699 -2.1790268 7.87E-04 MITOTIC SPINDLE ORGANIZATION GOBP GO:0007052 -0.56178665 -2.1668727 8.29E-04 ACTIVATION OF HOX GENES DURING DIFFERENTIATION REACTOME DATA5619507 -0.5286699 -2.1765668 8.35E-04 CHROMOSOME SEGREGATION GOBP GO:0007059 -0.45319012 -2.1753561 8.38E-04 CYTOSOLIC RIBOSOME GOCC GO:0022626 -0.50444806 -2.1721873 8.41E-04 CHROMATIN REMODELING AT CENTROMERE GOBP GO:0031055 -0.65665895 -2.161826 8.89E-04 OXIDATIVE STRESS INDUCED SENESCENCE REACTOME R-HSA-25595 -0.5192428 -2.155485 0.001001933 MAJOR PATHWAY OF RRNA PROCESSING IN THE NUCLEOLUS AND CYTOSOL REACTOME R-HSA-67912 -0.4624777 -2.1452315 0.001167388 TELOMERE MAINTENANCE REACTOME R-HSA-15757 -0.5530116 -2.1383371 0.001283138 CYTOSOLIC LARGE RIBOSOMAL SUBUNIT GOCC GO:0022625 -0.5608371 -2.1385064 0.001300022 M PHASE REACTOME R-HSA-68886 -0.41587985 -2.1358948 0.001328491 FOXM1 TRANSCRIPTION FACTOR NETWORK PATHWAY INTERAFOXM1 TRAN -0.60052544 -2.135986 0.00133241 MITOTIC PROPHASE REACTOME R-HSA-68875 -0.4942152 -2.1263888 0.001505547 PID_FOXM1_PATHWAY MSIGDB_C2 PID_FOXM1_ -0.60052544 -2.122859 0.001550746 RMTS METHYLATE HISTONE ARGININES REACTOME DATA3214858 -0.5657502 -2.118984 0.001607762 RRNA PROCESSING REACTOME DATA 72312 -0.44803128 -2.1167307 0.001637727 FORMATION OF TUBULIN FOLDING INTERMEDIATES BY CCT TRIC REACTOME DATA 389960 -0.7050918 -2.1152744 0.001642793 CENP-A CONTAINING NUCLEOSOME ASSEMBLY GOBP GO:0034080 -0.6432537 -2.1133406 0.001683574 RNA POLYMERASE I CHAIN ELONGATION REACTOME DATA 73777 -0.5528381 -2.1107483 0.001711447 POLYSOMAL RIBOSOME GOCC GO:0042788 -0.6460145 -2.1042626 0.001858789 REGULATION OF EXPRESSION OF SLITS AND ROBOS REACTOME R-HSA-90105 -0.44507292 -2.104358 0.001880154 COOPERATION OF PREFOLDIN AND TRIC CCT IN ACTIN AND TUBULIN FOLDING REACTOME R-HSA-38995 -0.62845445 -2.088597 0.002277374 PACKAGING OF TELOMERE ENDS REACTOME R-HSA-17130 -0.65000606 -2.080138 0.002651238 DNA DAMAGE TELOMERE STRESS INDUCED SENESCENCE REACTOME DATA2559586 -0.5375497 -2.0782206 0.002671207 COLLAGEN FIBRIL ORGANIZATION GOBP GO:0030199 -0.60682774 -2.0793498 0.002678138 DNA CONFORMATION CHANGE GOBP GO:0071103 -0.43305117 -2.0766084 0.002697319 CONDENSED CHROMOSOME KINETOCHORE GOCC GO:0000777 -0.6636201 -2.0709631 0.002878674 GASTRIC CANCER NETWORK 1 WIKIPATHWAYS_WP2361 -0.65141666 -2.0716405 0.002887203 BETA1 INTEGRIN CELL SURFACE INTERACTIONS PATHWAY INTERABETA1 INTEG -0.5077757 -2.0693812 0.002913974 HDACS DEACETYLATE HISTONES REACTOME DATA3214815 -0.53765255 -2.0695431 0.002944327 MITOTIC METAPHASE PLATE CONGRESSION GOBP GO:0007080 -0.579084 -2.0682173 0.00295817 ESTABLISHMENT OF PROTEIN LOCALIZATION TO GOBP GO:0072599 -0.4633644 -2.0610769 0.003198969 CENP-A CONTAINING CHROMATIN ORGANIZATION GOBP GO:0061641 -0.6432537 -2.0588217 0.003289965 HALLMARK_MITOTIC_SPINDLE MSIGDB_C2 HALLMARK_M -0.42153054 -2.052091 0.003593408 ESTABLISHMENT OF CHROMOSOME LOCALIZATION GOBP GO:0051303 -0.5488757 -2.040149 0.004295733 CHROMOSOME LOCALIZATION GOBP GO:0050000 -0.54312956 -2.0391335 0.004313918 PREFOLDIN MEDIATED TRANSFER OF SUBSTRATE TO CCT TRIC REACTOME DATA 389957 -0.6317135 -2.0364854 0.004390878 RUNX1 REGULATES TRANSCRIPTION OF GENES INVOLVED IN DIFFERENTIATION OF HSCS REACTOME R-HSA-89392 -0.48289245 -2.0348325 0.004414659 PID_PLK1_PATHWAY MSIGDB_C2 PID_PLK1_PA -0.58326447 -2.0352144 0.004427443 PID_INTEGRIN1_PATHWAY MSIGDB_C2 PID_INTEGRIN -0.5077758 -2.033631 0.004507646 METAPHASE PLATE CONGRESSION GOBP GO:0051310 -0.5462963 -2.0323637 0.004590211 MEIOSIS REACTOME R-HSA-15006 -0.48034424 -2.0303485 0.004717072 REPRODUCTION REACTOME DATA1474165 -0.46509326 -2.0281825 0.00477713 RIBOSOMAL SUBUNIT GOCC GO:0044391 -0.43297997 -2.0272968 0.004789345 RHO GTPASE EFFECTORS REACTOME R-HSA-19525 -0.4019322 -2.0232632 0.004904879 REGULATION OF CHROMOSOME SEGREGATION GOBP GO:0051983 -0.46655422 -2.0244684 0.004911813 RNA CATABOLIC PROCESS GOBP GO:0006401 -0.41616046 -2.0179012 0.00509597 MITOTIC SPINDLE GOCC GO:0072686 -0.47416502 -2.0086133 0.005641225 PLK1 SIGNALING EVENTS PATHWAY INTERAPLK1 SIGNALI -0.5717403 -2.0076203 0.005645649 NUCLEAR-TRANSCRIBED MRNA CATABOLIC PROCESS GOBP GO:0000956 -0.42385826 -2.0066338 0.005702088 ORGANELLE FISSION GOBP GO:0048285 -0.40748608 -1.997713 0.006473778 REGULATION OF MITOTIC SISTER CHROMATID SEPARATION GOBP GO:0010965 -0.5271849 -1.9885684 0.007369204 KINESIN COMPLEX GOCC GO:0005871 -0.55606794 -1.9827416 0.007801017 PROTEIN HETEROTETRAMERIZATION GOBP GO:0051290 -0.6360677 -1.9831355 0.007822938 MITOTIC SPINDLE CHECKPOINT REACTOME DATA 69618 -0.4621804 -1.9799516 0.008065687 POSITIVE REGULATION OF SUBSTRATE ADHESION-DEPENDENT CELL SPREADING GOBP GO:1900026 -0.61117506 -1.9777724 0.008225549 MRNA CATABOLIC PROCESS GOBP GO:0006402 -0.41409418 -1.9748493 0.008339969 AMPLIFICATION OF SIGNAL FROM THE KINETOCHORES REACTOME DATA 141424 -0.47669113 -1.975509 0.008341705 WOUND HEALING, SPREADING OF CELLS GOBP GO:0044319 -0.64020705 -1.9736507 0.008379256 LARGE RIBOSOMAL SUBUNIT GOCC GO:0015934 -0.4576925 -1.9727315 0.008419038 RNA POLYMERASE I PROMOTER CLEARANCE REACTOME R-HSA-73854 -0.48030677 -1.9713861 0.008496184 POSITIVE EPIGENETIC REGULATION OF RRNA EXPRESSION REACTOME R-HSA-52509 -0.4822976 -1.9718724 0.008506065 ESR-MEDIATED SIGNALING REACTOME R-HSA-89392 -0.4369939 -1.9703736 0.008541946 EPIBOLY INVOLVED IN WOUND HEALING GOBP GO:0090505 -0.64020705 -1.9682803 0.008626366 KINESINS REACTOME R-HSA-98318 -0.55684555 -1.964451 0.008934625 SPINDLE LOCALIZATION GOBP GO:0051653 -0.6061494 -1.9632924 0.009006274 ESTROGEN-DEPENDENT GENE EXPRESSION REACTOME R-HSA-90185 -0.44561046 -1.9592062 0.009261377 EPIBOLY GOBP GO:0090504 -0.62103295 -1.9594656 0.00932283 CHECKPOINTS REACTOME R-HSA-69620 -0.39487946 -1.9568049 0.009373315 PROTEIN-DNA COMPLEX SUBUNIT ORGANIZATION GOBP GO:0071824 -0.4100801 -1.956977 0.009412484 HISTONE EXCHANGE GOBP GO:0043486 -0.5427822 -1.9542246 0.00957358 NORC NEGATIVELY REGULATES RRNA EXPRESSION REACTOME DATA 427413 -0.48086536 -1.950969 0.009884831 AMPLIFICATION OF SIGNAL FROM UNATTACHED KINETOCHORES VIA A MAD2 INHIBITORY SIGNAREACTOME DATA 141444 -0.47669113 -1.9514498 0.009896341 MEIOTIC SYNAPSIS REACTOME DATA1221632 -0.5090199 -1.9498637 0.009960075 POLYSOME GOCC GO:0005844 -0.48229274 -1.9367442 0.01167139 PROTEIN LOCALIZATION TO ENDOPLASMIC RETICULUM GOBP GO:0070972 -0.43015948 -1.9356674 0.011820626 CORNIFICATION GOBP GO:0070268 -0.46641046 -1.9351078 0.011831286 PID_AURORA_B_PATHWAY MSIGDB_C2 PID_AURORA -0.5601285 -1.9282619 0.01281394 CHROMOSOME CONDENSATION GOBP GO:0030261 -0.60043824 -1.9251662 0.013031688 CYTOSOLIC SMALL RIBOSOMAL SUBUNIT GOCC GO:0022627 -0.54136634 -1.925934 0.013036256 AURORA B SIGNALING PATHWAY INTERAAURORA B SIG -0.5601285 -1.9210099 0.013569248 RESOLUTION OF SISTER CHROMATID COHESION REACTOME R-HSA-25002 -0.45660025 -1.9201864 0.013602301 CYTOSOLIC PART GOCC GO:0044445 -0.39751163 -1.9185174 0.013721558 PID_E2F_PATHWAY MSIGDB_C2 PID_E2F_PAT -0.47307262 -1.9186006 0.013799327 ACTIVATION OF THE MRNA UPON BINDING OF THE CAP-BINDING COMPLEX AND EIFS, AND SUBSREACTOME DATA 72662 -0.48709184 -1.9134443 0.014309689 TRANSLATION REACTOME DATA 72766 -0.37830943 -1.9135809 0.014389728 NUCLEOSOMAL DNA BINDING GOMF GO:0031492 -0.5424314 -1.9140489 0.014410593 INTEGRIN CELL SURFACE INTERACTIONS REACTOME R-HSA-21608 -0.47726524 -1.9116203 0.014574874 REGULATION OF PROTEIN TARGETING TO GOBP GO:1903214 -0.5403826 -1.9084511 0.014969296 DETECTION OF CHEMICAL STIMULUS INVOLVED IN SENSORY PERCEPTION GOBP GO:0050907 -0.58996123 -1.9026568 0.01572863 FORMATION OF THE TERNARY COMPLEX, AND SUBSEQUENTLY, THE 43S COMPLEX REACTOME DATA 72695 -0.5078023 -1.9029336 0.015756639 RNA POLYMERASE I TRANSCRIPTION REACTOME R-HSA-73864 -0.47135153 -1.903155 0.015811443 CHROMOSOME SEPARATION GOBP GO:0051304 -0.6477366 -1.9000021 0.01606678 REGULATION OF CHROMOSOME SEPARATION GOBP GO:1905818 -0.49881393 -1.8994188 0.01608832 PROTEIN-DNA COMPLEX ASSEMBLY GOBP GO:0065004 -0.42018837 -1.8968958 0.016489822 LAMININ INTERACTIONS REACTOME DATA3000157 -0.60939425 -1.8950708 0.016634487 CELLULAR SENESCENCE REACTOME R-HSA-25595 -0.40621954 -1.8954569 0.016654558 RIBOSOME GOCC GO:0005840 -0.3917 -1.8908845 0.01720758 CHROMOSOME, CENTROMERIC REGION GOCC GO:0000775 -0.42087173 -1.8873914 0.01771015 SPINDLE ORGANIZATION GOBP GO:0007051 -0.43552482 -1.8844299 0.018172616 CONDENSED NUCLEAR CHROMOSOME GOCC GO:0000794 -0.48602834 -1.8810941 0.01865862 NUCLEOSOME BINDING GOMF GO:0031491 -0.47071445 -1.8760619 0.019527983 NEGATIVE EPIGENETIC REGULATION OF RRNA EXPRESSION REACTOME R-HSA-52509 -0.46660495 -1.8762312 0.01961924 EXTRACELLULAR MATRIX ORGANIZATION GOBP GO:0030198 -0.3757088 -1.8744159 0.01980996 REGULATION OF PEPTIDYL-THREONINE PHOSPHORYLATION GOBP GO:0010799 -0.5670405 -1.8727572 0.020119818 PID_INTEGRIN3_PATHWAY MSIGDB_C2 PID_INTEGRIN -0.49286896 -1.8688551 0.020918585 SPINDLE GOCC GO:0005819 -0.3794391 -1.8657702 0.021535788 ESTABLISHMENT OF SPINDLE LOCALIZATION GOBP GO:0051293 -0.5723164 -1.8646623 0.021670729 MITOTIC ANAPHASE REACTOME R-HSA-68882 -0.39082742 -1.8630637 0.021915337 CELL DIVISION GOBP GO:0051301 -0.41679037 -1.8621428 0.021982472 TRANSLATION INITIATION COMPLEX FORMATION REACTOME DATA 72649 -0.48709184 -1.8588868 0.02269789 KERATINIZATION REACTOME R-HSA-68055 -0.44297987 -1.856265 0.022930425 PID_UPA_UPAR_PATHWAY MSIGDB_C2 PID_UPA_UPA -0.53393793 -1.8563396 0.023057817 MITOTIC METAPHASE AND ANAPHASE REACTOME R-HSA-25553 -0.3951616 -1.8565329 0.023158047 INTERMEDIATE FILAMENT GOCC GO:0005882 -0.51532614 -1.8531458 0.023493264 BETA3 INTEGRIN CELL SURFACE INTERACTIONS PATHWAY INTERABETA3 INTEG -0.5002874 -1.8521078 0.02367355 POSITIVE REGULATION OF CYTOKINESIS GOBP GO:0032467 -0.5537879 -1.8510345 0.02387426 HATS ACETYLATE HISTONES REACTOME R-HSA-32148 -0.426199 -1.8503666 0.023889797 TRANSCRIPTION FACTOR NETWORK PATHWAY INTERAE2F TRANSCR -0.4730726 -1.8485208 0.024253007 PATHOGENIC ESCHERICHIA COLI INFECTION WIKIPATHWAYS_WP2272 -0.48343247 -1.8409582 0.025820658 RIBOSOMAL SCANNING AND START CODON RECOGNITION REACTOME R-HSA-72702 -0.48137775 -1.8402522 0.025846971 PID_LYMPH_ANGIOGENESIS_PATHWAY MSIGDB_C2 PID_LYMPH_A -0.59102637 -1.841053 0.025958002 SKIN DEVELOPMENT GOBP GO:0043588 -0.40517038 -1.8411878 0.02605326 REGULATION OF MITOTIC METAPHASE/ANAPHASE TRANSITION GOBP GO:0030071 -0.49897906 -1.8391465 0.026056174 VEGFR3 SIGNALING IN LYMPHATIC ENDOTHELIUM PATHWAY INTERAVEGFR3 SIGN -0.5910263 -1.8358274 0.026782965 BINDING AND UPTAKE OF LIGANDS BY SCAVENGER RECEPTORS REACTOME DATA2173782 -0.5016736 -1.8334384 0.027221331 REGULATION OF METAPHASE/ANAPHASE TRANSITION OF CELL CYCLE GOBP GO:1902099 -0.49265388 -1.8336567 0.027303277 UROKINASE-TYPE PLASMINOGEN ACTIVATOR (UPA) AND UPAR-MEDIATED SIGNALING PATHWAY INTERAUROKINASE-T -0.53393793 -1.8316903 0.027604105 KINETOCHORE GOCC GO:0000776 -0.4262909 -1.8306981 0.027778499 RHO GTPASES ACTIVATE FORMINS REACTOME R-HSA-56632 -0.4283401 -1.8274388 0.028379282 PID_EPHA2_FWD_PATHWAY MSIGDB_C2 PID_EPHA2_F -0.6260793 -1.8262967 0.028413702 HDMS DEMETHYLATE HISTONES REACTOME R-HSA-32148 -0.55707216 -1.8277371 0.02844516 RIBOSOMAL SMALL SUBUNIT BIOGENESIS GOBP GO:0042274 -0.48922345 -1.826515 0.02848939 POSITIVE REGULATION OF PROTEIN LOCALIZATION TO PLASMA MEMBRANE GOBP GO:1903078 -0.4969561 -1.8199462 0.029897014 RIBOSOMAL LARGE SUBUNIT ASSEMBLY GOBP GO:0000027 -0.55981743 -1.8206812 0.02993828 KERATINIZATION GOBP GO:0031424 -0.445117 -1.8200953 0.030019708 MITOTIC SPINDLE ASSEMBLY GOBP GO:0090307 -0.5544318 -1.8170083 0.030275054 SEPARATION OF SISTER CHROMATIDS REACTOME DATA2467813 -0.38834354 -1.8171419 0.030382719 PROTEIN TARGETING TO MEMBRANE GOBP GO:0006612 -0.4023933 -1.8153627 0.030502938 PROTEIN HETEROOLIGOMERIZATION GOBP GO:0051291 -0.48311505 -1.817217 0.030516734 TP53 REGULATES TRANSCRIPTION OF CELL CYCLE GENES REACTOME DATA6791312 -0.50331545 -1.8154259 0.030625407 SENSORY PERCEPTION OF BITTER TASTE GOBP GO:0050913 -0.5991606 -1.8085684 0.032637484 ESTABLISHMENT OF MITOTIC SPINDLE LOCALIZATION GOBP GO:0040001 -0.606297 -1.8063524 0.033079296 SIGNALING BY ROBO RECEPTORS REACTOME R-HSA-37617 -0.3716069 -1.8064599 0.033177618 CHROMOSOMAL REGION GOCC GO:0098687 -0.36633146 -1.8048761 0.0333601 PID_FAK_PATHWAY MSIGDB_C2 PID_FAK_PAT -0.46845123 -1.8038207 0.033512842 ASSEMBLY OF COLLAGEN FIBRILS AND OTHER MULTIMERIC STRUCTURES REACTOME R-HSA-20220 -0.46495962 -1.7985343 0.03521893 NEGATIVE REGULATION OF SISTER CHROMATID SEGREGATION GOBP GO:0033046 -0.5766517 -1.7916625 0.037436914 FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION REACTOME DATA 983231 -0.3910877 -1.7893218 0.03816338 RETINOBLASTOMA GENE IN CANCER WIKIPATHWAYS_WP2446 -0.42352432 -1.7869864 0.038504023 SIGNALING EVENTS MEDIATED BY FOCAL ADHESION KINASE PATHWAY INTERASIGNALING EV -0.46535492 -1.7879019 0.038508564 CELL REDOX HOMEOSTASIS GOBP GO:0045454 -0.5298902 -1.7872583 0.038595885 DETECTION OF CHEMICAL STIMULUS INVOLVED IN SENSORY PERCEPTION OF BITTER TASTE GOBP GO:0001580 -0.5991606 -1.7848059 0.039090753 NEGATIVE REGULATION OF CHROMOSOME SEGREGATION GOBP GO:0051985 -0.56648844 -1.7838637 0.03917407 SCAVENGING BY CLASS A RECEPTORS REACTOME DATA3000480 -0.6005086 -1.7797687 0.039782777 TRANSLATION GOBP GO:0006412 -0.3515851 -1.7799703 0.039863925 EPHA2 FORWARD SIGNALING PATHWAY INTERAEPHA2 FORW -0.6260793 -1.7816092 0.03987839 DETECTION OF CHEMICAL STIMULUS INVOLVED IN SENSORY PERCEPTION OF TASTE GOBP GO:0050912 -0.5641704 -1.7800258 0.040000413 REGULATION OF MITOTIC SISTER CHROMATID SEGREGATION GOBP GO:0033047 -0.4501492 -1.7803735 0.04008268 AUTONOMIC NERVOUS SYSTEM DEVELOPMENT GOBP GO:0048483 -0.5707225 -1.771407 0.04232773 MITOTIC PROMETAPHASE REACTOME DATA 68877 -0.37260556 -1.7714126 0.042513374 CHAPERONE COMPLEX GOCC GO:0101031 -0.5875451 -1.7715428 0.04265088 CADHERIN BINDING GOMF GO:0045296 -0.3443157 -1.7676735 0.04359989 MET PROMOTES CELL MOTILITY REACTOME R-HSA-88758 -0.52313125 -1.7651788 0.044332113 APC-CDC20 MEDIATED DEGRADATION OF NEK2A REACTOME DATA 179409 -0.60073763 -1.7638358 0.04474749 POST-CHAPERONIN TUBULIN FOLDING PATHWAY REACTOME DATA 389977 -0.58355826 -1.7603983 0.04593171 REGULATION OF SISTER CHROMATID SEGREGATION GOBP GO:0033045 -0.4340138 -1.759502 0.046073966 POSITIVE REGULATION OF PROTEIN IMPORT GOBP GO:1904591 -0.55436534 -1.7553157 0.047718786 RIBOSOME BIOGENESIS GOBP GO:0042254 -0.35972825 -1.7496021 0.049697403 POSITIVE REGULATION OF PROTEIN LOCALIZATION TO CELL PERIPHERY GOBP GO:1904377 -0.4654208 -1.7498965 0.04981187