Oligomonocytic Chronic Myelomonocytic Leukemia
Modern Pathology (2017) 30, 1213–1222 © 2017 USCAP, Inc All rights reserved 0893-3952/17 $32.00 1213 Oligomonocytic chronic myelomonocytic leukemia (chronic myelomonocytic leukemia without absolute monocytosis) displays a similar clinicopathologic and mutational profile to classical chronic myelomonocytic leukemia Julia T Geyer1, Wayne Tam1, Yen-Chun Liu1, Zhengming Chen2, Sa A Wang3, Carlos Bueso-Ramos3, Jean Oak4, Daniel A Arber5, Eric Hsi6, Heesun J Rogers6, Katherine Levinson7, Adam Bagg7, Duane C Hassane1, Robert P Hasserjian8 and Attilio Orazi1 1Department of Pathology and Laboratory Medicine, Weill Cornell Medical College, New York, NY, USA; 2Division of Biostatistics and Epidemiology, Department of Healthcare Policy & Research, Weill Cornell Medical College, New York, NY, USA; 3Department of Hematopathology, the University of Texas MD Anderson Cancer Center, Houston, TX, USA; 4Department of Pathology, Stanford University, Stanford, CA, USA; 5Department of Pathology, University of Chicago, Chicago, IL, USA; 6Department of Laboratory Medicine, Cleveland Clinic, Cleveland, OH, USA; 7Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA, USA and 8Department of Pathology, Massachusetts General Hospital, Boston, MA, USA Chronic myelomonocytic leukemia is characterized by persistent absolute monocytosis (≥1×109/l) in the peripheral blood and dysplasia in ≥ 1 lineages. In the absence of dysplasia, an acquired clonal genetic abnormality is required or causes for reactive monocytosis have to be excluded.
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