biomedicines Review Experimental and Clinical Applications of Red and Near-Infrared Photobiomodulation on Endothelial Dysfunction: A Review Esteban Colombo 1,† , Antonio Signore 1,2,†, Stefano Aicardi 3, Angelina Zekiy 4, Anatoliy Utyuzh 4, Stefano Benedicenti 1 and Andrea Amaroli 1,4,* 1 Laser Therapy Centre, Department of Surgical and Diagnostic Sciences, University of Genoa, 16132 Genoa, Italy;
[email protected] (E.C.);
[email protected] (A.S.);
[email protected] (S.B.) 2 Department of Therapeutic Dentistry, Faculty of Dentistry, First Moscow State Medical University (Sechenov University), 119991 Moscow, Russia 3 Department for the Earth, Environment and Life Sciences, University of Genoa, 16132 Genoa, Italy;
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[email protected] (A.Z.);
[email protected] (A.U.) * Correspondence:
[email protected]; Tel.: +39-010-3537309 † These authors contributed equally to this work. Abstract: Background: Under physiological conditions, endothelial cells are the main regulator of arterial tone homeostasis and vascular growth, sensing and transducing signals between tissue Citation: Colombo, E.; Signore, A.; and blood. Disease risk factors can lead to their unbalanced homeostasis, known as endothelial Aicardi, S.; Zekiy, A.; Utyuzh, A.; dysfunction. Red and near-infrared light can interact with animal cells and modulate their metabolism Benedicenti, S.; Amaroli, A. upon interaction with mitochondria’s cytochromes, which leads to increased oxygen consumption, Experimental and Clinical Applications ATP production and ROS, as well as to regulate NO release and intracellular Ca2+ concentration. of Red and Near-Infrared This medical subject is known as photobiomodulation (PBM).