DOCSLIB.ORG

Melbourne, Australia Seth Masters, the Walter and Eliza Hall Institute, Victoria, Australia Kate Schroder, the University of Queensland, Brisbane, Australia

Total Page：16

File Type：pdf, Size：1020Kb

Download full-text PDF Read full-text
Melbourne, Australia Seth Masters, the Walter and Eliza Hall Institute, Victoria, Australia Kate Schroder, the University of Queensland, Brisbane, Australia Welcome The International Cytokine and Interferon Society 2014 Annual Meeting Cytokines Down Under: From Bench to Beyond 26th October – 29th October, 2014 Melbourne Convention & Exhibition Centre Dear colleagues, On behalf of the Scientific Organizing Committee, it is with great pleasure to welcome you to Melbourne to attend the second annual meeting of the International Cytokine and Interferon Society (ICIS). Specific topics will include the latest aspects on the biology, signal transduction and gene regulation of cytokines, interferons and their receptors in innate and adaptive immunity, as well as pattern recognition receptors and their role in host-pathogen interactions, infectious diseases, inflammation, cancer, autoimmunity and metabolism. Sessions will include cutting edge basic science and clinical presentations in plenary and concurrent symposia, as well as eminent keynote presentations, and are strongly supported by poster sessions and trade displays. The meeting promises to provide an outstanding forum for basic science and clinical researchers to present their latest data and exchange ideas relating to the broad role of cytokines and interferons in human disease, and applications to therapies. In addition, the meeting will provide strong networking opportunities for scientists in the biotechnology and pharmaceutical industries. We are pleased with the attendance from all over the globe by both established and new investigators and students –Thanks for your support. We thank the Society and all sponsors who have helped to make this happen. This broad attendance, will help assure a vibrant and exciting conference for all. We also note that Australia, and Melbourne in particular, is a perfect location to visit at this time of year, being in the peak of Spring. Melbourne is a vibrant and multicultural city known as the “sporting capital of Australia”, being home to the Australian Tennis Open, Australian Formula 1 Grand Prix, and the Spring Racing Carnival featuring the Melbourne Cup (first Tuesday in November), one of the largest and most prestigious horse races in the world. Together with its renowned riverside atmosphere, café culture, nearby beaches and wineries, it is no surprise Melbourne has been voted the most liveable city in the world for the 4th year in a row, with other Australian capital cities Adelaide, Sydney and Perth also featuring in the top 10. We trust you will have a most productive conference and memorable experience whilst in Australia. Brendan Jenkins and Paul Hertzog Co-convenors The International Cytokine and Interferon Society 2014 Annual Meeting - Page 1 Index Page SECTION 1 – INTRODUCTION AND DELEGATE INFORMATION Welcome 1 Contents 2 Organising Committee 3 Sponsors 4 Keynote Speakers 5 Symposia Speakers 6 2014 Award Winners 17 Delegate Information 18 Venue Map 21 Melbourne Information 22 Sponsor / Exhibitor Listing & Map 23 SECTION 2 – SCIENTIFIC PROGRAM Full Program : Sunday 28 Monday 30 Tuesday 35 Wednesday 39 SECTION 3 – PRESENTING AUTHOR INDEX 43 SECTION 4 – ABSTRACTS Speaker Abstracts 67 Meeting Abstracts 70 SECTION 5 – DELEGATE LIST 138 The International Cytokine and Interferon Society 2014 Annual Meeting - Page 2 Organising Committee Convenors Secretariat Paul Hertzog, MIMR-PHI Institute of Medical Research, Maree Overall, ASN Events Pty Ltd Victoria, Australia Kara Taglieri, ASN Events Pty Ltd Brendan Jenkins, MIMR-PHI Institute of Medical Research, Victoria, Australia Local Organising Committee Iain Campbell, University of Sydney, NSW, Australia Angel Lopez, Centre for Cancer Biology, SA, Australia Ashley Mansell, MIMR-PHI Institute of Medical Research, Victoria, Australia Sandra Nicholson, Walter and Eliza Hall Institute of Medical Research, Victoria, Australia Matt Sweet, Institute for Molecular Bioscience, Queensland, Australia International Scientific Advisory Committee Vishva Dixit, Research Genentech, Inc., United States Eleanor Fish, University Health Network, Canada Sarah Gaffen, University of Pittsburgh, United States Simon Jones, Cardiff University, United Kingdom Doug Hilton, Walter and Eliza Hall Institute of Medical Research, Australia Hong Tang, Chinese Academy of Sciences, China Luke O’Neill, Trinity College Dublin, Ireland Masanobu Oshima, Kanzawa University, Japan. Leon Platanias, Robert H. Lurie Comprehensive Cancer Center, United States Stefan Rose-John, University of Kiel, Germany Bryan Williams, MIMR-PHI Institute of Medical Research, Australia Howard Young, National Cancer Institute at Frederick, United States The International Cytokine and Interferon Society 2014 Annual Meeting - Page 3 Sponsors The Organising Committee for the International Cytokine & Interferon Society 2014 Meeting acknowledges with gratitude, the generous support received from the following sponsors: GOLD SPONSORS SILVER SPONSORS BRONZE SPONSORS SPONSORS The International Cytokine and Interferon Society 2014 Annual Meeting - Page 4 Keynote Speakers Peter Doherty, University of Melbourne Professor Peter Doherty shared the Nobel Prize in Physiology or Medicine in 1996 with Swiss colleague Rolf Zinkernagel, for their discovery of how the immune system recognises virus-infected cells. He was Australian of the Year in 1997, and has since been commuting between St Jude Children’s Research Hospital in Memphis and the Department of Microbiology and Immunology at the University of Melbourne. His research is mainly in the area of defence against viruses. He regularly devotes time to delivering public lectures, writing articles for newspapers and magazines and participating in radio discussions. Peter Doherty graduated from the University of Queensland in Veterinary Science and became a veterinary officer. Moving to Scotland, he received his PhD from the University of Edinburgh Medical School. He is the first person with a veterinary qualification to win a Nobel Prize. Peter is also the author of several books, including “A Light History of Hot Air”, “The Beginners Guide to Winning the Nobel Prize” and "Sentinel Chickens: What birds tell us about our health and the world". Nicos Nicola, Walter and Eliza Hall Institute of Medical Research Dr. Nicola’s laboratory has focused on the molecular regulation of haemopoietic cell production and function for over 30 years. A major emphasis has been on the cytokines that regulate the production and functional activation of granulocytes and macrophages, two types of white blood cells that co-ordinate innate immune responses to bacterial and viral infections. His work has led to the identification, purification and/or molecular cloning of several important cytokines (G-CSF, GM-CSF and leukaemia inhibitory factor (LIF)), the identification and molecular cloning of several cytokine receptors (including the GM-CSF, interleukin-11 and interleukin-13 receptors) and the identification of a new family of inducible, intracellular inhibitors of these cytokine/receptor signaling pathways. These suppressors of cytokine signaling (SOCS) proteins have been shown to have crucial roles in vivo in limiting the extent and duration of responses to various cytokines thus preventing excessive inflammatory and autoimmune responses. He is also investigating the role of cytokines and cytokine signaling pathways in the development and maintenance of leukaemic cell populations and the usefulness of cytokines or cytokine antagonists as therapies or adjunct therapies in cancer treatments. Luke O’Neill, Trinity College Dublin The major focus of the group is to provide a molecular understanding of innate immunity and inflammation. We are interested in receptors involved in innate immunity, such as Toll-like receptors (TLRs) and Nod-like receptors (NLRs – including Nlrp3), and also signals activated, including NF-kappaB, IRF family transcription factors and MAP kinases. The role played by this system in inflammatory diseases is also under investigation. We have several projects underway including – Role of the adapter Mal in the epithelial barrier in the gut, Control of TLRs and NLRs by microRNAs, Role of Nlrp3 in Type 2 diabetes, Novel proteins in the TLR and NLR systems, The role of Btk in TLR signalling, The control of trafficking of TLR4, Genetic variation in innate immune genes and inflammatory diseases, Role of IL-36 in inflammation. The International Cytokine and Interferon Society 2014 Annual Meeting - Page 5 Symposia Speakers Shizuo Akira, Osaka University Shizuo Akira is a director and professor of WPI Immunology Frontier Research Center, and also a professor in Institute for Microbial Diseases at Osaka University, Japan. He received his M.D. and Ph.D. from Osaka University. After two years of postdoctoral working in Department of Immunology, University of California at Berkeley, he started to study on IL-6 gene regulation and signaling in the Institute for Molecular and Cellular Biology, Osaka University, and cloned transcription factors, NF-IL6(C/EBP beta) and STAT3. He was a professor in Department of Biochemistry, Hyogo College of Medicine from 1996 to 1999, where he became involved in Toll-like receptors research. By generating TLR family knockout mice, he identified ligands of many TLR members. He also demonstrated that the difference in signaling pathway among TLRs is due to selective usage of adaptor molecules such as MyD88 and TRIF. He demonstrated that pathogen-derived RNA is recognized by cytoplasmic receptor family, besides TLRs, and clarified the molecular mechanism of antiviral response against RNA viruses. His current research interests are molecular mechanisms
Load more

Recommended publications
  • Patterns, Paradoxes and Personalities Medical History Museum, University of Melbourne the Story of Cancer Is Complex and Extremely Personal
    THE cancer puzzle patterns, paradoxes and personalities Medical History Museum, University of Melbourne The story of cancer is complex and extremely personal. One in two Australian men and one in three Australian women will be diagnosed with cancer by the age of 85. For generations, doctors and researchers have been searching for remedies for this disease, which has long been shrouded in fear and dread. While surgery, radiotherapy and chemotherapy are still the main treatments, radically new approaches and technologies are emerging, together with a much more sophisticated understanding of the causes and very nature of cancer. Central to the story of cancer in Victoria has been the contribution of the University of Melbourne, in undertaking fundamental and applied research, developing treatments, training clinicians and scientists, educating the public, and advocating for change. Significant figures in the Melbourne Medical School, such as Professor Peter MacCallum, have helped build the infrastructure that underpins cancer services for the Victorian community. The cancer puzzle: Patterns, paradoxes and personalities explores the roles of individuals, public education campaigns and research efforts, as well as revealing patients’ insights through the work and writings of three contemporary artists who have cancer. the cancer puzzle PATTERNS, PARADOXES AND PERSONALITIES Edited by Jacqueline Healy Medical History Museum University of Melbourne Contents Foreword vii Published 2017 by the Medical History Museum, The exhibition The cancer puzzle: Patterns, paradoxes and personalities, Professor Mark Cook Faculty of Medicine, Dentistry and Health Sciences, curated by Dr Jacqueline Healy, was held at the Medical History University of Melbourne, Victoria, 3010, Australia Museum, University of Melbourne, from 1 August 2017 to Sponsor’s message ix 24 February 2018.
    [Show full text]
  • Law Student Mental Health Literacy and Distress: Finances, Accommodation and Travel Time Nerissa Soh the University of Sydney
    Legal Education Review Volume 25 | Issue 1 Article 3 1-1-2015 Law Student Mental Health Literacy and Distress: Finances, Accommodation and Travel Time Nerissa Soh The University of Sydney Fiona Burns The University of Sydney Rita Shackel The University of Sydney Bruce Robinson The University of Sydney Michael Robertson The University of Sydney See next page for additional authors Follow this and additional works at: https://epublications.bond.edu.au/ler Part of the Legal Education Commons Recommended Citation Soh, Nerissa; Burns, Fiona; Shackel, Rita; Robinson, Bruce; Robertson, Michael; and Walter, Garry (2015) "Law Student Mental Health Literacy and Distress: Finances, Accommodation and Travel Time," Legal Education Review: Vol. 25 : Iss. 1 , Article 3. Available at: https://epublications.bond.edu.au/ler/vol25/iss1/3 This Article is brought to you by the Faculty of Law at ePublications@bond. It has been accepted for inclusion in Legal Education Review by an authorized administrator of ePublications@bond. For more information, please contact Bond University's Repository Coordinator. Law Student Mental Health Literacy and Distress: Finances, Accommodation and Travel Time Authors Nerissa Soh, Fiona Burns, Rita Shackel, Bruce Robinson, Michael Robertson, and Garry Walter This article is available in Legal Education Review: https://epublications.bond.edu.au/ler/vol25/iss1/3 Soh et al.: Law Student Mental Health Literacy and Distress LAW STUDENT MENTAL HEALTH LITERACY AND DISTRESS: FINANCES, ACCOMMODATION AND TRAVEL TIME __________________________________________________________________________ NERISSA SOH, FIONA BURNS, RITA SHACKEL, BRUCE ROBINSON, MICHAEL ROBERTSON AND GARRY WALTER I INTRODUCTION University students often have higher levels of psychological distress than the general population.
    [Show full text]
  • Golden Yearbook
    Golden Yearbook Golden Yearbook Stories from graduates of the 1930s to the 1960s Foreword from the Vice-Chancellor and Principal ���������������������������������������������������������5 Message from the Chancellor ��������������������������������7 — Timeline of significant events at the University of Sydney �������������������������������������8 — The 1930s The Great Depression ������������������������������������������ 13 Graduates of the 1930s ���������������������������������������� 14 — The 1940s Australia at war ��������������������������������������������������� 21 Graduates of the 1940s ����������������������������������������22 — The 1950s Populate or perish ���������������������������������������������� 47 Graduates of the 1950s ����������������������������������������48 — The 1960s Activism and protest ������������������������������������������155 Graduates of the 1960s ���������������������������������������156 — What will tomorrow bring? ��������������������������������� 247 The University of Sydney today ���������������������������248 — Index ����������������������������������������������������������������250 Glossary ����������������������������������������������������������� 252 Produced by Marketing and Communications, the University of Sydney, December 2016. Disclaimer: The content of this publication includes edited versions of original contributions by University of Sydney alumni and relevant associated content produced by the University. The views and opinions expressed are those of the alumni contributors and do
    [Show full text]
  • Longitudinal Single Cell Fate of Hematopoiesis in Vivo Using Cellular Barcoding
    bioRxiv preprint doi: https://doi.org/10.1101/279406; this version posted March 9, 2018. The copyright holder for this preprint (which was not certified by peer review) is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under aCC-BY-NC-ND 4.0 International license. Longitudinal single cell fate of hematopoiesis in vivo using cellular barcoding and DiSNE movie visualization Short title: Longitudinal single cell fate in hematopoiesis Jerry Gao1,2, Dawn S. Lin1,2,3, Edmund Crampin,4,5,6, Shalin H. Naik1,2,3,* 1Molecular Medicine, The Walter & Eliza Hall Institute of Medical Research, Parkville, Victoria 3052, Australia 2Immunology, The Walter & Eliza Hall Institute of Medical Research, Parkville, Victoria 3052, Australia 3Faculty of Medicine, Dentistry & Health Sciences, University of Melbourne, Parkville, Victoria 3010, Australia. 4Systems Biology Laboratory, University of Melbourne, Parkville, Victoria 3010, Australia 5Centre for Systems Genomics, University of Melbourne, Parkville, Victoria 3010, Australia 6ARC Centre of EXcellence in Convergent Bio-Nano Science and Technology, Melbourne School of Engineering, University of Melbourne, Parkville, Victoria 3010, Australia. *Corresponding author. bioRxiv preprint doi: https://doi.org/10.1101/279406; this version posted March 9, 2018. The copyright holder for this preprint (which was not certified by peer review) is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available
    [Show full text]
  • 2010-2011 Annual Report
    Annual Report 2010-2011 Mastery of disease through discovery | www.wehi.edu.au Contents 1 About the institute 3 Director’s and Chairman’s report 5 Discovery 8 Cancer and Haematology 10 Stem Cells and Cancer 12 Molecular Genetics of Cancer 14 Chemical Biology 16 Molecular Medicine 18 Structural Biology 20 Bioinformatics 22 Infection and Immunity 24 Immunology The Walter and Eliza Hall Institute 26 Autoimmunity and Transplantation of Medical Research 28 Cell Signalling and Cell Death 1G Royal Parade 30 Inflammation Parkville Victoria 3052 Australia Telephone: (+61 3) 9345 2555 32 Molecular Immunology Facsimile: (+61 3) 9347 0852 34 Publications WEHI Biotechnology Centre 36 Awards 4 Research Avenue 37 Translation La Trobe R&D Park Bundoora Victoria 3086 Australia Translating our research 38 Telephone: (+61 3) 9345 2200 40 Developing our research Facsimile: (+61 3) 9345 2211 42 Patents www.wehi.edu.au www.facebook.com/WEHIresearch 43 Education www.twitter.com/WEHI_research 46 2010-11 graduates ABN 12 004 251 423 47 Seminars Acknowledgements 48 Institute awards Produced by the institute’s Community Relations department 49 Engagement Managing editor: Penny Fannin Editor: Liz Williams 51 Strategic partners Writers: Liz Williams, Vanessa Solomon and Julie Tester 52 Scientific and medical community Design and production: Simon Taplin Photography: Czesia Markiewicz and Cameron Wells 54 Public engagement 57 Engagement with schools Cover image 58 Donor and bequestor engagement Art in Science finalist 2010 Vessel webs 59 Sustainability Dr Leigh Coultas, Cancer and Haematology division 60 The Board This image shows the delicate intricacy in the developing eye of a transient population of web-like blood vessels.
    [Show full text]
  • June 2015.Indd
    Australasian Society for Immunology Inc. NEWSLETTER PP 100000910 ISSN 1442-8725 June 2015 ContentsContents Feature article: Immunology & Cell Biology 3 Editorial 6 Christina Cheers: Hon. Life Member 8 2014 Jomar Poster Prize Winner 12 3D reconstruction of a murine lymph node. Honorary Secretary’s News 14 red: blood vessels, green: dextran-labelled phagocytes, grey: lymphatic sinuses. Lupus Research at Monash University 15 Inken Kelch and colleagues (see page 2) Visiting Speaker Program 20 Upcoming Conferences 10 Day of Immunology 22 Councillors’ News 27 Travel Award Conference Reports 30 Publications List 32 ASI Inc. Newsletter June 2015 ASI Inc. COUNCIL Non-Voting Councillors: Newsletter Editor President Past President Ms Joanna Roberts Professor Christopher Goodnow Professor Dale Godfrey Ph: 64 6 357 0654 Department Immunology Dept of Microbiology & Immunology Email: [email protected] JCSMR, ANU Peter Doherty Institute PO Box 334, Canberra ACT 2601 University of Melbourne Parkville Vic 3010 Journal Editor Ph: 61 2 6125 2394 Ph: 61 3 8344 6831 Dr Gabrielle Belz Email: [email protected] Email: [email protected] Ph: 61 3 9345 2544 Email: [email protected] Honorary Secretary Honorary Treasurer A/Prof. Stuart Berzins Dr John Stambas Visiting Speakers Co-ordinator CRN Section, School of Health Sciences AAHL, CSIRO Deakin Collaborative Lab. Dr Joanna Kirman Federation University Australia Private Bag 24 Ph: 64 3 479 7712 Mt Helen Vic 3352 East Geelong Vic 3220 Email: [email protected] Ph: 61 3 5320 2039 Ph: 61 3 5227
    [Show full text]
  • ANNEX List of Overseas Medical Schools with Registrable Basic
    ANNEX List of overseas medical schools with registrable basic medical qualifications (from 1 Jan 2020) Country / Body Granting Qualifications Region Australia The University of Adelaide Faculty of Health Sciences The University of Melbourne Melbourne Medical School Monash University Faculty of Medicine, Nursing and Health Sciences University of New South Wales Faculty of Medicine The University of Queensland School of Medicine The University of Sydney Sydney Medical School The University of Western Australia Faculty of Medicine, Dentistry and Health Sciences Australian National University ANU Medical School Austria Medizinische Universität Wien Belgium Katholieke Universiteit Leuven, Faculteit Geneeskunde Canada University of British Columbia Faculty of Medicine McGill University Faculty of Medicine McMaster University Michael G. DeGroote School of Medicine University of Toronto Faculty of Medicine University of Alberta Faculty of Medicine and Dentistry Université de Montréal Faculté de Médecine University of Calgary Cumming School of Medicine Denmark Aarhus Universitet Det Sundhedsvidenskabelige Fakultet Finland University of Helsinki Faculty of Medicine France Sorbonne University Faculty of Medicine Country / Body Granting Qualifications Region Germany Ruprecht-Karls-Universität Heidelberg Medizinische Fakultät Heidelberg Ludwig-Maximilians-Universität München Medizinische Fakultät Charité-Universitätsmedizin Berlin Hong Kong The Chinese University of Hong Kong Special Faculty of Medicine Administrative The University of Hong Kong Region,
    [Show full text]
  • THE JOHN CURTIN SCHOOL of MEDICAL RESEARCH Annual Review 2013
    THE JOHN CURTIN SCHOOL OF MEDICAL RESEARCH Annual Review 2013 ANU College of Medicine, Biology & Environment CONTENTS Annual Review 2013 The John Curtin School of Medical Research From the Director 3 Staff and student lists 87 Department of Genome Biology 88 Organisation Chart 4 Department of Immunology 90 Committees 5 Eccles Institute of Neuroscience 92 Department of Molecular Bioscience 94 Community 7 Department of Translational Medicine 96 Department of Pathogens and Immunity 96 Centenary of Canberra 2013 Australian Phenomics Facility 97 14th Frank and Bobbie Fenner Conference 8 School Administration 98 The John Curtin Medical Research Foundation Dinner 9 School Services 98 David Curtis Reading Room 10 The ACRF Biomolecular Resource Facility Open Day 2013 11 and Genome Discovery Unit 99 Community Activities 12 Students 100 Research in Review 2013 15 Publications, presentations and Eccles Institute of Neuroscience 16 community outreach 103 Department of Genome Biology 30 Publications 104 Department of Immunology 38 Staff Presentations 110 Department of Pathogens and Immunity 48 Student Presentations 117 Department of Molecular Bioscience 52 Community Outreach 121 Department of Translational Medicine 58 Australian Phenomics Facility 60 Support to JCSMR 131 The Imaging and Cytometry Facility 62 Grants 132 The ACRF Biomolecular Resource Facility Financial Overview 136 and Genome Discovery Unit 63 Donors 137 Staff and student achievements 65 Sponsors 138 Graduates 66 Prizes and Awards 67 Visitors and collaborations 71 Visitors 72 Collaborations 74 Annual Review 2013 1 2 The John Curtin School of Medical Research FROM THE DIRECTOR Following the opening of Stage 3 of our new building in 2012, JCSMR staff and students have enjoyed the opportunities provided by the new spaces, including the laboratories, and meeting rooms such as the Science Forum.
    [Show full text]
  • International Medical Schools
    International Medical Schools All American Institute of Medical Sciences; requirements (see "MD Program"); Facebook; Twitter All Saints University School of Medicine, Dominica; requirements; Facebook All Saints University School of Medicine, St. Vincent and the Grenadines; requirements; Facebook American International Medical University School of Medicine; requirements; Facebook American University of Antigua College of Medicine; requirements; Facebook; Twitter American University of Integrative Sciences School of Medicine; requirements; Facebook American University of the Caribbean School of Medicine; requirements; Facebook; Twitter Atlanta Central University Seoul Central College of Medicine; requirements Atlantic Bridge Program Irish Medical Schools; entry requirements Aureus University School of Medicine; requirements Avalon University School of Medicine; requirements; Facebook; Twitter Ben Gurion University of the Negev Medical School for International Health; requirements (scroll down to "Eligibility Requirements"); Facebook; Twitter Caribbean Medical University School of Medicine; requirements; Facebook Central American Health Sciences University Belize Medical College; requirements Duke-NUS Medical School; requirements; Facebook; Twitter Flinders University School of Medicine; requirements (scroll down to "Academic requirements"); Facebook FlindersU; Twitter FlindersU Hope Medical Institute; requirements; Facebook Humanitas University; requirements; Facebook International American University College of Medicine; requirements;
    [Show full text]
  • Modifying Clonal Selection Theory with a Probabilistic Cell
    DOI: 10.1111/imr.12695 INVITED REVIEW Modifying clonal selection theory with a probabilistic cell Philip D. Hodgkin1,2 1Immunology Division, The Walter & Eliza Hall Institute of Medical Research, Parkville, Summary Vic., Australia Problem- solving strategies in immunology currently utilize a series of ad hoc, qualita- 2 Department of Medical Biology, The tive variations on a foundation of Burnet’s formulation of clonal selection theory. University of Melbourne, Parkville, Vic., Australia These modifications, including versions of two- signal theory, describe how signals regulate lymphocytes to make important decisions governing self- tolerance and Correspondence: Philip D. Hodgkin, Immunology Division, The Walter & Eliza changes to their effector and memory states. These theories are useful but are prov- Hall Institute of Medical Research, 1G Royal ing inadequate to explain the observable genesis and control of heterogeneity in cell Parade, Parkville, VIC 3050, Australia ([email protected]). types, the nonlinear passage of cell fate trajectories and how the input from multiple environmental signals can be integrated at different times and strengths. Here, I Funding information National Health and Medical Research argue for a paradigm change to place immune theory on a firmer philosophical and Council (NH&MRC), Grant/Award quantitative foundation to resolve these difficulties. This change rejects the notion Number: 1054925; NH&MRC Research Fellowship, 1079136; Victorian State of identical cell subsets and substitutes the concept of a cell as comprised of autono- Government Operational Infrastructure mous functional mechanical components subject to stochastic variations in construc- Support; Australian Government NH&MRC Independent Research Institutes tion and operation. The theory aims to explain immunity in terms of cell population Infrastructure Support Scheme, Grant/ dynamics, dictated by the operation of cell machinery, such as randomizing elements, Award Number: 361646 division counters, and fate timers.
    [Show full text]
  • Standard Setting in Australian Medical Schools
    The University of Notre Dame Australia ResearchOnline@ND Medical Papers and Journal Articles School of Medicine 2018 Standard setting in Australian medical schools Helena Ward Neville Chiavaroli James Fraser Kylie Mansfield Darren Starmer The University of Notre Dame Australia, [email protected] See next page for additional authors Follow this and additional works at: https://researchonline.nd.edu.au/med_article Part of the Medicine and Health Sciences Commons This article was originally published as: Ward, H., Chiavaroli, N., Fraser, J., Mansfield, K., Starmer, D., Surmon, L., Veysey, M., & O'Mara, D. (2018). Standard setting in Australian medical schools. BMC Medical Education, 18. Original article available here: https://doi.org/10.1186/s12909-018-1190-6 This article is posted on ResearchOnline@ND at https://researchonline.nd.edu.au/med_article/924. For more information, please contact [email protected]. Authors Helena Ward, Neville Chiavaroli, James Fraser, Kylie Mansfield, Darren Starmer, Laura Surmon, Martin Veysey, and Deborah O'Mara This article is available at ResearchOnline@ND: https://researchonline.nd.edu.au/med_article/924 This is an Open Access article distributed in accordance with the Creative Commons Attribution 4.0 International (CC BY 4.0) License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. See: https://creativecommons.org/licenses/by/4.0/ This article originally published in BMC Medical Education available at: https://doi.org/10.1186/s12909-018-1190-6 Ward, H., Chiavaroli, N., Fraser, J., Mansfield, K., Starmer, D., Surmon, L., Veysey, M., and O’Mara, D. (2018).
    [Show full text]
  • The Charles Perkins Centre: a New Model for Tackling Chronic Disease
    The Charles Perkins Centre: a new model for tackling chronic disease Stephen J. Simpson The University of Sydney Page 1 Like all animals, humans have evolved to minimize energy expenditure and maximize accessibility to safe and palatable food The University of Sydney Page 2 We have built a world that meets our ancestral ‘heart’s desire’ … and is killing us • Food production and supply systems maximize the qualities missing in our ancestral environments. • Cities, homes and workplaces designed to allow minimal energy expenditure. • Economic systems are designed to value wealth over health. • Companies that sell us what we want prosper; even if that means selling us foods that degrade health. • Prevention is better than cure, yet makes little profit or garners votes in the short term. The University of Sydney Page 3 Why is a University well placed to offer solutions? • Endless source of clever young people at their peak of creativity • Huge multidisciplinary potential – a one-stop-shop • But need to break down disciplinary silos to gain depth and breadth The University of Sydney Page 4 What was CPC asked to deliver for the University? • Bring University together across its disciplines and locations and collocate critical research mass to address this major societal problem • Build new collaborative, multi-disciplinary research and education with impact • Design, build and populate the CPC Research and Education Hub The University of Sydney Page 5 And for society - our mission: To ease the burden of obesity, diabetes, cardiovascular disease and related conditions by generating collaborative research and education that translates into real-world solutions “…health of the nation and its children is inextricably linked to a complex web of influences...” (National Academy of Science, Accelerating Progress in Obesity Prevention: Solving the Weight of the Nation).
    [Show full text]