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Major Discussions and Tabular Citations Are Noted in Bold Type Index Major discussions and tabular citations are noted in bold type. A acetyl enzyme 75-76 exchange reactions 75 Aasa, R. 41,42,58 kinetics 75 Abbott, S.l. 97 mechanism 75-76 Abdullah, M. 111 Acetyl-CoA carboxylase 220 Abeles, R.H. 9,24,28,34,54,55, 79, Acetyl-CoA synthetase 208-209,220 80, 151, 177, 178, 181, 185, 189, acetyl adenylate 208-209 190, 201 acetyl enzyme 208-209 Abramovitz, A.S. 77 exchange reaction 208 - 209 Abramson, R. 112 inversion of configuration on Acetaldehyde 177 -179 phosphorus 209 hydration 172 mechanism 208 - 209 Acetate Co A-transferase 108 triple-displacement reaction 209 Acetate kinase 92-96, 108 Acetylesterase 147 exchange reactions 93 N-Acetylglucosamine 89-90 kinetics 94 Acetylglucosamine phosphomutase mechanism 95 108 mercuric ion, effects on 94, 96 f3-N- Acetylglucosaminidase 147 noncontiguous binding of Acetylium ion 18 substrates 94-96 N-Acetylneuraminate lyase 182 nuc1eosidediphosphate kinase Acetyl phosphate 92-96, 202, 217 activity 93-94 Acid phosphatase 120-121, 147 phosphoenzyme 92-96 phosphoenzyme 120 steric inversion on phosphorus 92 Acid protease from Rhizopus surface walk 96 chinensis 149 triple displacement 92, 95 Aconitase 182 Acetoacetate decarboxylase 17, Aconitate ~-isomerase 200 157 -158, 182 Acrosin 148 exchange reactions 157 -158 Actinidin 148 mechanism 157 Activation of water 114, 119, 130-131, Schiff base intermediates 157 145-146,173,177 Acetoacetate, decarboxylation, [Acyl-carrier protein] nonenzymic 17 acetyltransferase 106 Acetoacetyl-CoA 75, 104-106, [Acy I-carrier -protein] 166-167 malonyltransferase 76-77, 106 Acetolactate synthase 182 malonyl enzyme 76-77 Acetyl adenylate 203 Acyl-CoA dehydrogenase 49 Acetylcholinesterase 147 Acyl-CoA hydrolase 147 Acetyl-CoA 17,74,75,76, 166, 167, Adachi, K., 56 168-170, 208, 209, 214 Adair, Jr., W.L. 195 Acetyl-CoA acetoacetate Adams, C.A. 112 Co A-transferase 108 Adams, E. 184, 200 Acetyl-CoA acetyltransferase 75 -76, Adams, R.W. 152 106 Adenine 80-82 238 Index Adenine phosphoribosyltransferase 10, retention of steric configuration of 80-83, 89, 107 phosphorus 119 mechanism 82 transferase activity 117 phosphoribosyl enzyme 81-82 Alkane-l-monooxygenase 51 steric inversion on carbon 10, 80-83 2-(5-n-alkyl)furoic acid, p-nitrophenyl surface walk 10 esters 134 triple displacement 82-83 Allen, S.H.G. 33 Adenosine deaminase 149 Allison, AJ. 222 Adenosylhomocysteinase 148 Allothreonine 64 Adenylic acid 80-81 Alston, T.A. 54 Adenylysulfate reductase 18-29, SO Alworth, W.L. 174 sulfite-enzyme adduct 29 Ambrose-Griffin, M.C. 6, 110 Aerts, G.M. 151 w-Amidase 149 Ahmad, F. 65 Amidophosphoribosyltransferase 107 Airas, R.K. 153 Amine oxidase (FAD) SO Akashi, K. 221 Amine oxidase (PLP) SO Akeson, A. 34 0-Amino-acid dehydrogenase SO Akhtar, M. 110 o-Amino-acid oxidase 23-27, SO f3- Alanine 207 - 208 o-alanine, as substrate 23, 27 Alanine aminotransferase 107 D-f3-chloralanine, elimination of D-Alanine aminotransferase 108 HCI 24-25 D-Alanine carboxypeptidase 148 cyanide ion, as inhibitor 24-25 Alanine racemase 186-188, 199 nitroethane, as substrate 24-25 mechanism 186-188 reconstituted with 5-deaza Schiff base intermediate 186-188 FAD 26-27 suicide substrates 188 shielded proton 25 Albers, R.W. 144, 146 L-Amino-acid oxidase 49 Alberts, A.W. 110 Aminoacylase 149 Albery, W.J. 39, 196 p-Aminobenzoate synthase 182 Albizati, L 153 Aminobutyrate aminotransferase 108 Alcohol dehydrogenase 33-38,49 Aminolevulinate dehydratase 182 catalytic use of NAD 33-34 8-Aminolevulinate synthase 106 coordination of substrates with zinc 35 4-Aminovalerate 159-160 trans-4-N,N-dimethylaminocinnam- AMP deaminase 149 aldehyde, as substrate 35 a-Amylase 147 dimutase activity 34 Amylo-l,6-glucosidase 148 mechanism 36-38 Amylosucrase 106 p-nitroso-N,N-dimethylaniline, as Anan, F.K. 55 substrate 35-36 Andani, Z. 152 Aldehyde oxidase 32, 49 Anderson, B.M. 127 Alden, R.A. 152 Anderson, C.M. 20,90 Aldrich, F.L. 132 Anderson, J.R. 2 Aldridge, W.N. 118 Anderson, L. 99, 150 Aleman, V. 54 Anderson, P.M. 112,222 Alexander, D.R. 144 Anderson, W.F. 88 Alger, J.R. 119 Andreasson, L.E. 41,42 Alkaline phosphatase, 117-120,147 A4-Androstene-3, 17-dione 196 activated water 119 AS- Androstene-3, 17 -dione 196 mechanism 119 Anfinsen, C.B. 11,94 orthophosphate-oxygen exchange 118 Angelides, KJ. 6, 126, 137 phosphoenzyme 117 -120 Angelis, C.T. 35 Index 239 Anke, H. 208 Asparaginase 149 Ankel, E. 111 Asparagine synthetase 220 Ankel, H. 111,195 Aspartate aminotransferase 84-86, 107 Anraku, Y. 219 kinetics 84 Anthony, R.S., VII 92,93 mechanism 84-85 Anthranilate synthase 182 a-methylaspartate, as substrate 84-85 Anthropomorphism in enzymic phosphopyridoxamine-enzyme 84 - 85 catalysis 13 -15 Schiff base intermediates 85-86 Antonini, E. 41, 54, 153 Aspartate ~-decarboxylase 182 Antonov, V.K. 138 D-Aspartate oxidase 49 Anwar, R.A. 111 Aspartate-semialdehyde Aparicio, P.J. 56 dehydrogenase 49 Apitz-Castro, R. 128 Aspergillus alkaline proteinase 148 Applebaum, J. 176 Aster, S.D. 183 Applebury, M. L. 119 Atkinson, R.F. 151 Appleby, C.A. 52 ATPase 144-147, 149 Arabinose isomerase 199 activation of water 145-146 L-Arabinose isomerase, 199 calcium-magnesium -dependent Araiso, T. 57 146-147 L-Arginine 69 electrogenic 147 Arginine decarboxylase 182 exchange reactions 146 Arginine 2-monooxygenase 51 inversion of configuration of Arginine racemase 199 phosphorus 147 Argument from analogy 91-92, 144, mechanism 145 223-224 phosphoenzyme 144-147 Arigoni, D. 178, 201 sodium -potassium- Arion, W.J. 121 dependent 144-146 Armitage,I.M. 119, 173,214 ATP citrase lyase 92,168-170,182 Arnold, W.J. 81 acetyl enzyme 169-170 Amon, D.1. 58 citryl enzyme 169-170 Arnone, A. 85 exchange reaction 169 Aromatic L-amino-acid mixed anhydride intermediate 170 decarboxylase 182 phosphoenzyme 169 -170 Aronson, J.N. 153 Au, A. M.J. 35 Arthrobacter serine proteinase 148 Augustinsson, K.B. 150 Arvidsson, L. 97 Aull, J.L. 150 Aryl acyl amidase 149 Avaeva, S.M. 143 Arylamine acetyltransferase 18, 74-75, Averill, B.A. 28, 59 106 Avigad, G. 110, 164 acetylenzyme 18, 74-75 Avron, M. 112 exchange reactions 74 Awad, W.M. 150 kinetics 74-75 Axcell, B.C. 57 Arylsulfatase 123-124, 147 Axeirod, B. 120, 151 kinetics 124 Axeisson, K. 46 sulfonyl enzyme 123-124 Ayling, J.E. 86 transferase activity 124 Asada, K. 56 Asano, A. 53 B Ascorbate oxidase 42, 51 Ashman, L.K. 215 Babior, B.M. 185, 201 AskelOf, P. 46 Babu, U.M. 188 240 Index Baumann, F. 151 Bachovchin, W.W. 178 Bayliss, R.S. 138 Bacitracin synthetase 220 Beachum, III, L.M. 53 Biickstrom, D. 58 Beaty, N.B. 30 Bacon, J.S.D. 110 Beaucamp, K. 156 Bacterialluciferase 49 Becker, M.A. 185 Baggott, J .E. 135 Beeler, T. 112 Bagirov, E.M. 112 Begard, E. 58 Bai, Y. 151 Begue-Canton, M.L. 136 Bailey, G.B. 184 Beinert, H. 54, 55, 56 Bailey, J.L. 55 Belasco, J.G. 154, 196 Baird, J.B. 152 Bell, R.M. 2 Bak, T.G. 53 Bendall, D.S. 58 Baker, 1.1. 201 Bender, M.L. 2, 133, 135, 136, 152 Bakuleva, N.P. 143 Benisek, W.F. 197 Balboni, G. 73, 164 Benjamin, W.B. 170 Baldwin, R.L. 185 Benkovic, S.J. 2, 19, 123, 124, 150 Balinsky, J .B. 221 Bennett, J. 153 Ballou, C.E. 111 Bennett, R. 54 Ballou, D.P. 30,31,48,58 Bennett, Jr., W.S. 88 Balls, A.K. 132 Benson, R. W. 104, 210 Balny, C. 31 Benzene 1,2-dioxygenase 51 Baltimore, B.G. 201 Benzil 116 Baltzinger, M. 207 Benzil monooxime 116 Bamforth, C.W. 55 Berg, P. 203, 208 Bandurski, R.S. 56 Bergamini, M.V.W. 110 Baratova, L.A. 143 Berger, A. 137 Baratti, J. 152 Bergmann, F. 150 Barden, R.E. 215 Bergsten, P.C. 173 Bardsley, W. G. 54 Bergstrom, B. 151 Barker, H.A. 8, 78, 201 Berman, K. 113 Barlow, C.H. 42,46 Berman, K.M. 91 Barman, T.E. 118 Berman, M. 144 Barnard, E.A. 120 Bernard, C. 9 Barnett, J.E.G. 184, 201 Bernath, P. 54 Barnett, R.E. 145 Berndt, M.C. 116 Barns, R.J. 162 Bernhard, S.A. 35, 53, 152 Baron, A. 150 Bernhardt, F.-H. 58 Baron, D. 184 Bernhardt, R. 54 Baron, J. 46, 58 Bessman, S.P. 74 Barra, D. 40 Bethge, P.H. 129 Barrett, H. 91,117 Bhaduri, A.P. 30 Barshevskaya, T.N. 138 Biellmann, J.-F. 35,53 Bartfai, T. 150 Bigbee, W.L. 153 Bartmann, P. 206 Bilirubin-glucuronoside Basu, M. 111 glucuronosyltransferase 107 Basu, S. 111 Billing, B.H. 111 Bates, D.L. 6 Bingham, A. 154 Battersby, A.R. 180 Binkley, S.B. 184 Bauer, C.-A. 153 Birch, M. 99 Baugn, R.L. 183 Birktoft,1.1. 131, 152 Index 241 Bisaz, S. 118 Boursnell, J .H. 115 Bis(4-nitrophenyl)phosphate 122-123 Bovier-Lapierre, C. 150 2,3-Bisphospho-D-glycerate 197 Boyer, P.D. 53,74,104,143,146,150, Bisphosphoglycerate phosphatase 147 177,210 Bisphosphoglycerate synthase 97, 108 Bradley, S. 150 Bisphosphoglyceromutase lOS Brady, F.O. 57 Black, M.K. 98 Bramlett? R.N. 56 Black, S. 55 Branched-chain-amino-acid Blackmore, P.F. 72 aminotransferase 108 Blackwell, L.F. 53 Brand, K. 73, 74, 109 Blake, R.C. 46 Branden, C.I. 34 Blakeley, R.L. 58, 136, 181 Branden, R. 41 Blankenhorn, G. 27,30 Brandt, K.G. 55 Blaschkowski, H.P. 110 Branlant, G. 35 BUittler, W.A. 11,87,92,112, 198 Branzoli, U.
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