ISSN 2070-2515
FAO PLANT PRODUCTION AND PROTECTION PAPER 227 Pesticide residues in food 2016
Special Session of the Joint FAO/WHO Meeting on Pesticide Residues
REPORT 2016
FAO Pesticide residues PLANT PRODUCTION AND PROTECTION in food 2016 PAPER Joint FAO/WHO Meeting 227 on Pesticide Residues
Report of the special session of the Joint Meeting of the FAO Panel of Experts on Pesticide Residues in Food and the Envi- ronment and the WHO Core Assessment Group on Pesticide Residues Geneva, Switzerland, 9–13 May 2016
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(e.g. cohort studies) No Diazinon/NHL – 2 papers excluded evaluation for given - the most complete and updated analysis with the greatest number of Diazinon/Lung – 2 papers excluded compound/cancer site participants for this compound/cancer site? (e.g. pooled case-control) Glyphosate/NHL – 2 papers excluded Tier 1 Yes screening 3. Is exposure assessment specific to compound No PaperPa is not relevant to risk criteria Diazinon/NHL – 1 paper excluded of interest? assessmentas for compound Yes 4. Quantitative exposure assessment (exposure No Paper is relevant but cannot expressed on a ratio scale) contribute information to a quantitative risk assessment Yes Paper is relevant and can contribute to quantitative risk assessment (i.e. hazard characterization) for compound/cancer site Overall summary ACTIONS - for each relevant paper: Extract information on quantitative exposure units. ACTIONS – for each compound/cancer site: Describe magnitude of effect/uncertainty Characterize hazard for each compound/cancer site from all studies Review quality of study based on IARC Monograph and evaluation contributing to quantitative risk assessment, e.g. forest plot (or meta- criteria. regression, time-permitting). 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3HVWLFLGHUHVLGXHVLQIRRG±5HSRUWRIWKH-RLQW0HHWLQJRIWKH)$23DQHORI([SHUWVRQ 3HVWLFLGH 5HVLGXHV LQ )RRG DQG WKH (QYLURQPHQW DQG WKH :+2 &RUH $VVHVVPHQW *URXSRQ 3HVWLFLGH5HVLGXHV)$23ODQW3URGXFWLRQDQG3URWHFWLRQ3DSHU 3HVWLFLGH UHVLGXHV LQ IRRG ± HYDOXDWLRQV 3DUW , 5HVLGXHV )$2 3ODQW 3URGXFWLRQ DQG 3URWHFWLRQ3DSHU 3HVWLFLGH UHVLGXHV LQ IRRG ± HYDOXDWLRQV 3DUW ,, 7R[LFRORJLFDO :RUOG +HDOWK 2UJDQL]DWLRQ A Joint Meeting of the FAO Panel of Experts on Pesticide Residues in Food and the Environment and the WHO Core Assessment Group on Pesticide Residues (JMPR) was held in Geneva, Switzerland, from 9 to 13 May 2016. The three pesticides evaluated at the meeting were placed on the agenda by the JMPR Secretariat following the recommendation of an electronic task force of the WHO Core Assessment Group that they be re-evaluated due to public health concerns identified by the International Agency for Research on Cancer (IARC) and the availability of a significant number of new studies. During the meeting, the WHO Core Assessment Group was responsible for reviewing epidemiological, toxicological and related data in order to establish acceptable daily intakes (ADIs) and acute reference doses (ARfDs) of the pesticides for humans, where necessary. As no residue data were requested, the FAO Expert was responsible for estimating the dietary exposures (both short-term and long-term) to the pesticides reveiewed and, on this basis, performed dietary risk assessments in relation to their ADIs or ARfDs. This report contains information on ADIs, ARfDs and general principles for the evaluation of pesticides. The recommendations of the Joint Meeting, including further research and information, are proposed for use by Member governments of the respective agencies and other interested parties. 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Relevance - For each compound/cancer site No Exclude compound combination - did IARC identify positive associations /cancer site combination from the body of epidemiological evidence? from evaluation Yeses 6 compound/cancerncer sitesit combinations Figure 1: Evaluation process for epidemiological ACTION - for each relevant compound/cancer site:te: evidence Identify all papers in IARC Monographs assessing relevant compound/cancer sites (positive and null The current effort is restricted cancer outcomes associations) Identify any papers published since IARC Monograph which address relevant compound/cancer site Search by hand (e.g. check reference lists of identified papers) for any papers potentially missed 26 papersers ididentifieden 2. For related papers that examined the same compound/cancer site is this: - the most recent publication with longest follow-up for this Malathion/NHL – 2 papers excluded Exclude paper from compound/cancer site? (e.g. cohort studies) No Diazinon/NHL – 2 papers excluded evaluation for given - the most complete and updated analysis with the greatest number of Diazinon/Lung – 2 papers excluded compound/cancer site participants for this compound/cancer site? (e.g. pooled case-control) Glyphosate/NHL – 2 papers excluded Tier 1 Yes screening 3. Is exposure assessment specific to compound No PaperPa is not relevant to risk criteria Diazinon/NHL – 1 paper excluded of interest? assessmentas for compound Yes 4. Quantitative exposure assessment (exposure No Paper is relevant but cannot expressed on a ratio scale) contribute information to a quantitative risk assessment Yes Paper is relevant and can contribute to quantitative risk assessment (i.e. hazard characterization) for compound/cancer site Overall summary ACTIONS - for each relevant paper: Extract information on quantitative exposure units. ACTIONS – for each compound/cancer site: Describe magnitude of effect/uncertainty Characterize hazard for each compound/cancer site from all studies Review quality of study based on IARC Monograph and evaluation contributing to quantitative risk assessment, e.g. forest plot (or meta- criteria. regression, time-permitting). 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3HVWLFLGHUHVLGXHVLQIRRG±5HSRUWRIWKH-RLQW0HHWLQJRIWKH)$23DQHORI([SHUWVRQ 3HVWLFLGH 5HVLGXHV LQ )RRG DQG WKH (QYLURQPHQW DQG WKH :+2 &RUH $VVHVVPHQW *URXSRQ 3HVWLFLGH5HVLGXHV)$23ODQW3URGXFWLRQDQG3URWHFWLRQ3DSHU 3HVWLFLGH UHVLGXHV LQ IRRG ± HYDOXDWLRQV 3DUW , 5HVLGXHV )$2 3ODQW 3URGXFWLRQ DQG 3URWHFWLRQ3DSHU 3HVWLFLGH UHVLGXHV LQ IRRG ± HYDOXDWLRQV 3DUW ,, 7R[LFRORJLFDO :RUOG +HDOWK 2UJDQL]DWLRQ A Joint Meeting of the FAO Panel of Experts on Pesticide Residues in Food and the Environment and the WHO Core Assessment Group on Pesticide Residues (JMPR) was held in Geneva, Switzerland, from 9 to 13 May 2016. The three pesticides evaluated at the meeting were placed on the agenda by the JMPR Secretariat following the recommendation of an electronic task force of the WHO Core Assessment Group that they be re-evaluated due to public health concerns identified by the International Agency for Research on Cancer (IARC) and the availability of a significant number of new studies. During the meeting, the WHO Core Assessment Group was responsible for reviewing epidemiological, toxicological and related data in order to establish acceptable daily intakes (ADIs) and acute reference doses (ARfDs) of the pesticides for humans, where necessary. As no residue data were requested, the FAO Expert was responsible for estimating the dietary exposures (both short-term and long-term) to the pesticides reveiewed and, on this basis, performed dietary risk assessments in relation to their ADIs or ARfDs. This report contains information on ADIs, ARfDs and general principles for the evaluation of pesticides. The recommendations of the Joint Meeting, including further research and information, are proposed for use by Member governments of the respective agencies and other interested parties. I5693E/1/05.16