Wednesday Scienti Ic Session Listings 639–830 Information at a Glance
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Neurotoxicity in Preclinical Models of Occupational Exposure to Organophosphorus Compounds
CORE Metadata, citation and similar papers at core.ac.uk Provided by Frontiers - Publisher Connector REVIEW published: 18 January 2017 doi: 10.3389/fnins.2016.00590 Neurotoxicity in Preclinical Models of Occupational Exposure to Organophosphorus Compounds Jaymie R. Voorhees 1, 2*, Diane S. Rohlman 2, 3, Pamela J. Lein 4 and Andrew A. Pieper 1, 2, 5, 6, 7, 8, 9* 1 Department of Psychiatry, University of Iowa Carver College of Medicine, Iowa City, IA, USA, 2 Interdisciplinary Graduate Program in Human Toxicology, University of Iowa Carver College of Medicine, Iowa City, IA, USA, 3 Department of Occupational and Environmental Health, University of Iowa College of Public Health, Iowa City, IA, USA, 4 Department of Molecular Biosciences, School of Veterinary Medicine, University of California, Davis, Davis, CA, USA, 5 Department of Neurology, University of Iowa Carver College of Medicine, Iowa City, IA, USA, 6 Department of Free Radical and Radiation Biology Program, University of Iowa Carver College of Medicine, Iowa City, IA, USA, 7 Department of Radiation Oncology Holden Comprehensive Cancer Center, University of Iowa Carver College of Medicine, Iowa City, IA, USA, 8 Department of Veteran Affairs, University of Iowa Carver College of Medicine, Iowa City, IA, USA, 9 Weill Cornell Autism Research Program, Weill Cornell Medical College, New York, NY, USA Organophosphorus (OPs) compounds are widely used as insecticides, plasticizers, and fuel additives. These compounds potently inhibit acetylcholinesterase (AChE), the enzyme that inactivates acetylcholine at neuronal synapses, and acute exposure to high Edited by: OP levels can cause cholinergic crisis in humans and animals. Evidence further suggests Stefano L. -
Breast Cancer Res 7
Available online http://breast-cancer-research.com/content/7/5/R753 ResearchVol 7 No 5 article Open Access Phosphorylation of estrogen receptor α serine 167 is predictive of response to endocrine therapy and increases postrelapse survival in metastatic breast cancer Hiroko Yamashita1, Mariko Nishio2, Shunzo Kobayashi3, Yoshiaki Ando1, Hiroshi Sugiura1, Zhenhuan Zhang2, Maho Hamaguchi1, Keiko Mita1, Yoshitaka Fujii1 and Hirotaka Iwase2 1Oncology and Immunology, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan 2Oncology and Endocrinology, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan 3Josai Municipal Hospital of Nagoya, Nagoya, Japan Corresponding author: Hiroko Yamashita, [email protected] Received: 29 Jan 2005 Revisions requested: 15 Apr 2005 Revisions received: 12 Jun 2005 Accepted: 28 Jun 2005 Published: 27 Jul 2005 Breast Cancer Research 2005, 7:R753-R764 (DOI 10.1186/bcr1285) This article is online at: http://breast-cancer-research.com/content/7/5/R753 © 2005 Yamashita et al.; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/ 2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract Introduction Endocrine therapy is the most important treatment Results Phosphorylation of ER-α Ser118, but not Ser167, was option for women with hormone-receptor-positive breast positively associated with overexpression of HER2, and HER2- cancer. The potential mechanisms for endocrine resistance positive tumors showed resistance to endocrine therapy. The involve estrogen receptor (ER)-coregulatory proteins and present study has shown for the first time that phosphorylation crosstalk between ER and other growth factor signaling of ER-α Ser167, but not Ser118, and expression of PRA and networks. -
Progestins Inhibit the Growth of MDA-MB-231 Cells Transfected with Progesterone Receptor Complementary DNA1
Vol. 5, 395–403, February 1999 Clinical Cancer Research 395 Progestins Inhibit the Growth of MDA-MB-231 Cells Transfected with Progesterone Receptor Complementary DNA1 Valerie C-L. Lin,2 Eng Hen Ng, Swee Eng Aw, INTRODUCTION Michelle G-K. Tan, Esther H-L. Ng, The involvement of progesterone in the growth and devel- Vivian S-W. Chan, and Gay Hui Ho opment of breast cancer has been increasingly recognized in recent years. However, the roles of progesterone in the growth Departments of Clinical Research, Ministry of Health (V. C-L. L., regulation of breast cancer are still controversial. Progestins are S. E. A., M. G-K. T., V. S-W. C.), and General Surgery, Singapore General Hospital (E. H. N., E. H-L. N., G. H. H.), Republic of found to stimulate growth, have no effect, or inhibit growth in Singapore 169608 breast cancer cells (1–13). The conflicting findings affect clin- ical decision as to whether progestins or antiprogestins would be more appropriate endocrine therapies for PgR3-positive breast ABSTRACT cancer. Although progestins such as MPA and megestrol acetate Because progesterone exerts its effects mainly via estro- are often effectively used in the treatment of breast cancer gen-dependent progesterone receptor (PgR), the expression (14–16), a number of reports advocate that antiprogestins may of progesterone’s effects may be overshadowed by the prim- be new powerful tools for treating hormone-dependent breast ing effect of estrogen. PgR expression vectors were trans- cancer (17–19). fected into estrogen receptor (ER)-a and PgR-negative The reasons for the inconsistency in reported effects of breast cancer cells MDA-MB-231; thus the functions of progestins are not clear, but the involvement of estrogen and ER progesterone could be studied independent of estrogens and in the demonstrated effects of progestins is an important factor ERs. -
Progesterone Receptor Isoform B Regulates the Oxtr-Plcl2-Trpc3 Pathway to Suppress Uterine Contractility
Progesterone receptor isoform B regulates the Oxtr-Plcl2-Trpc3 pathway to suppress uterine contractility Mary C. Peaveya,1, San-Pin Wub,1, Rong Lib, Jian Liub, Olivia M. Emeryb, Tianyuan Wangc, Lecong Zhouc, Margeaux Wetendorfd, Chandra Yallampallie, William E. Gibbonse, John P. Lydond, and Francesco J. DeMayob,2 aDepartment of Obstetrics and Gynecology, University of North Carolina, Chapel Hill, NC 27599; bReproductive and Developmental Biology Laboratory, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709; cIntegrative Bioinformatic Support Group, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709; dDepartment of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030; and eDepartment of Obstetrics and Gynecology, Baylor College of Medicine, Houston, TX 77030 Edited by R. Michael Roberts, University of Missouri, Columbia, MO, and approved January 19, 2021 (received for review June 6, 2020) Uterine contractile dysfunction leads to pregnancy complications The “progesterone receptor isoform switch” concept was posited such as preterm birth and labor dystocia. In humans, it is hypoth- to explain the transition from a quiescent to a contractile myometrial esized that progesterone receptor isoform PGR-B promotes a re- phenotype in the presence of high levels of progesterone (10, 11, laxed state of the myometrium, and PGR-A facilitates uterine 26–30). Progesterone acts via the nuclear receptor isoforms, PGR-A contraction. This hypothesis was tested in vivo using transgenic and PGR-B, which are coexpressed at different levels throughout mouse models that overexpress PGR-A or PGR-B in smooth muscle pregnancy (31–35). Progesterone can transactivate different tran- cells. Elevated PGR-B abundance results in a marked increase in scriptional programs determined by the relative levels of PGR-A and gestational length compared to control mice (21.1 versus 19.1 d PGR-B isoforms in the myometrium (36–41). -
The Novel Progesterone Receptor
0013-7227/99/$03.00/0 Vol. 140, No. 3 Endocrinology Printed in U.S.A. Copyright © 1999 by The Endocrine Society The Novel Progesterone Receptor Antagonists RTI 3021– 012 and RTI 3021–022 Exhibit Complex Glucocorticoid Receptor Antagonist Activities: Implications for the Development of Dissociated Antiprogestins* B. L. WAGNER†, G. POLLIO, P. GIANGRANDE‡, J. C. WEBSTER, M. BRESLIN, D. E. MAIS, C. E. COOK, W. V. VEDECKIS, J. A. CIDLOWSKI, AND D. P. MCDONNELL Department of Pharmacology and Cancer Biology (B.L.W., G.P., P.G., D.P.M.), Duke University Medical Center, Durham, North Carolina 27710; Molecular Endocrinology Group (J.C.W., J.A.C.), NIEHS, National Institutes of Health, Research Triangle Park, North Carolina 27709; Department of Biochemistry and Molecular Biology (M.B., W.V.V.), Louisiana State University Medical School, New Orleans, Louisiana 70112; Ligand Pharmaceuticals, Inc. (D.E.M.), San Diego, California 92121; Research Triangle Institute (C.E.C.), Chemistry and Life Sciences, Research Triangle Park, North Carolina 27709 ABSTRACT by agonists for DNA response elements within target gene promoters. We have identified two novel compounds (RTI 3021–012 and RTI Accordingly, we observed that RU486, RTI 3021–012, and RTI 3021– 3021–022) that demonstrate similar affinities for human progeste- 022, when assayed for PR antagonist activity, accomplished both of rone receptor (PR) and display equivalent antiprogestenic activity. As these steps. Thus, all three compounds are “active antagonists” of PR with most antiprogestins, such as RU486, RTI 3021–012, and RTI function. When assayed on GR, however, RU486 alone functioned as 3021–022 also bind to the glucocorticoid receptor (GR) with high an active antagonist. -
Culture Characters, Genetic Background, Estrogen/Progesterone Receptor Expression, and Tumorigenic Activities of Frequently Used
Clinica Chimica Acta 489 (2019) 225–232 Contents lists available at ScienceDirect Clinica Chimica Acta journal homepage: www.elsevier.com/locate/cca Culture characters, genetic background, estrogen/progesterone receptor expression, and tumorigenic activities of frequently used sixteen T endometrial cancer cell lines Wanglei Qua,1, Yinling Zhaob,1, Xuan Wangc,1, Yaozhi Qid, Clare Zhoue, Ying Huaa, ⁎⁎ ⁎ Jianqing Houc, , Shi-Wen Jianga,f, a Department of Obstetrics and Gynecology, The Second Affiliated Hospital and Yuying Children's Hospitable of Wenzhou Medical University, Wenzhou 325027, China b Department of Gynecology, Taizhou People's Hospital, Taizhou 225300, Jiangsu, China c Department of Gynecology, Yantai Yuhuangding Hospital, Qingdao University School of Medicine, Yantai 264000, Shandong Province, China. d Department of Clinical Laboratory, Lianyungang Maternal and Child Health Hospital, Jiangsu 222005, China e Department of Obstetrics and Gynecology, Mayo Medical College, Rochester 55901, MN, USA f Department of Biomedical Science, Mercer University School of Medicine, Savannah, GA 31404, USA ARTICLE INFO ABSTRACT Keywords: Background: This study aimed to determine the in vitro and in vivo properties of sixteen frequently used en- Endometrial cancer dometrial cancer (EC) cell lines, including the cell proliferation rate, morphology, hormone receptor expression Hormone receptor patterns, PTEN, hMLH1 expression, p53 mutation, karyotype, and tumorigenicity in mouse xenograt model. PTEN Methods: Twelve type I (AN3, ECC-1, EN, EN-1, EN-11, HEC-1A, HECe1B, Ishikawa, KLE, MFE-280, MFE-296, hMLH1 MFE-319) and four type II (ARK1, ARK2, HEC-155/180, SPEC-2) endometrial cancer cell lines were studied. Cell p53 mutation proliferation and morphology were determined using cell growth curves and light microscopy, respectively. -
International Slr Service
ARTIFICIAL SATELLITES, Vol. 46, No. 4 – 2011 DOI: 10.2478/v10018-012-0004-z INTERNATIONAL SLR SERVICE Stanisław Schillak Space Research Centre, Polish Academy of Sciences Astrogeodynamic Observatory, Borowiec e-mail: [email protected] ABSTRACT The paper presents the current state of the International Laser Ranging Service (ILRS): distribution of the SLR stations, data centers, analysis centers. The paper includes also the information about the last International Workshop on Laser Ranging in Bad Koetzting, 16-20 May, 2011. The problems of quality of the SLR data are presented. The list of parameters which can be used for estimation of the accuracy of the SLR data for each station is given. Results of determination of the station position stabilities over long term period (from 1994 up to 2008) for the selected few main stations are presented in the five years blocks. The results show slight deterioration of accuracy observed for the last several years and the reasons for this effect are indicated. Keywords: satellite geodesy, satellite laser ranging, ILRS, orbital analysis 1. INTERNATIONAL LASER RANGING SERVICE http://ilrs.gsfc.nasa.gov/ The International Laser Ranging Service (ILRS) (Pearlman et al., 2002) organizes and coordinates Satellite Laser Ranging (SLR) and Lunar Laser Ranging (LLR) to support programs in geodetic, geophysical, and lunar research activities and provides the International Earth Rotation and Reference Frame Service (IERS) with products important to the maintenance of an accurate International Terrestrial Reference -
Malathion Human Health and Ecological Risk Assessment Final Report
SERA TR-052-02-02c Malathion Human Health and Ecological Risk Assessment Final Report Submitted to: Paul Mistretta, COR USDA/Forest Service, Southern Region 1720 Peachtree RD, NW Atlanta, Georgia 30309 USDA Forest Service Contract: AG-3187-C-06-0010 USDA Forest Order Number: AG-43ZP-D-06-0012 SERA Internal Task No. 52-02 Submitted by: Patrick R. Durkin Syracuse Environmental Research Associates, Inc. 5100 Highbridge St., 42C Fayetteville, New York 13066-0950 Fax: (315) 637-0445 E-Mail: [email protected] Home Page: www.sera-inc.com May 12, 2008 Table of Contents Table of Contents............................................................................................................................ ii List of Figures................................................................................................................................. v List of Tables ................................................................................................................................. vi List of Appendices ......................................................................................................................... vi List of Attachments........................................................................................................................ vi ACRONYMS, ABBREVIATIONS, AND SYMBOLS ............................................................... vii COMMON UNIT CONVERSIONS AND ABBREVIATIONS.................................................... x CONVERSION OF SCIENTIFIC NOTATION .......................................................................... -
Probabilistic Assessment of the Cumulative Acute Exposure to Organophosphorus and Carbamate Insecticides in the Brazilian Diet E.D
Toxicology 222 (2006) 132–142 Probabilistic assessment of the cumulative acute exposure to organophosphorus and carbamate insecticides in the Brazilian diet E.D. Caldas a,∗, P.E. Boon b, J. Tressou c a Department of Pharmaceutical Sciences, College of Health Sciences, University of Bras´ılia, 70919-970 Bras´ılia, DF, Brazil b RIKILT, Institute of Food Safety, Wageningen University and Research Centre, 6708 PD Wageningen, The Netherlands c INRA, Unit´eM´et@risk, Methodologies d’analyse de risque alimentaire INA-PG, 75231 Paris, France Received 10 October 2005; received in revised form 1 February 2006; accepted 13 February 2006 Available online 6 March 2006 Abstract In the present study, the cumulative exposure of 25 acetylcholinesterase (AChE) inhibiting pesticides through the consumption of nine fruits and vegetables by the Brazilian population was assessed. Food consumption data were obtained from a household budget survey conducted in all Brazilian states from July 2002 to June 2003. Residue data from 4001 samples were obtained from the Brazilian national monitoring program on pesticide residues. Relative potency factors (RPF) were calculated with methamidophos or acephate as index compounds (IC), using BMD10 or NOAEL for AChE inhibition, mostly in rat brain, obtained from national and international pesticide evaluations. Monocrotophos and triazophos, in addition to aldicarb, had the highest calculated RPF in any scenario. The exposure to AChE inhibiting pesticides for the general population at P99.9, represented 33.6% of the ARfD as methamidophos and 70.2% ARfD as acephate. The exposure calculated as acephate could exceed the ARfD at the upper bound of the 95% confidence interval for this percentile. -
The Dietary Supplement Specialists
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Molecular Identification and Characterization of a and B Forms of the Glucocorticoid Receptor
Molecular Identification and Characterization of A and B Forms of the Glucocorticoid Receptor Matthew R. Yudt and John A. Cidlowski Laboratory of Signal Transduction National Institute of Environmental Health Sciences Downloaded from https://academic.oup.com/mend/article/15/7/1093/2748001 by guest on 27 September 2021 National Institutes of Health Research Triangle Park, North Carolina 27709 The human glucocorticoid receptor (hGR␣)isa responsive promoters reveal the shorter hGR-B to ligand-activated transcription factor that mediates be nearly twice as effective as the longer hGR-A the physiological effects of corticosteroid hor- species in gene transactivation, but not in transre- mones and is essential for life. Originally cloned in pression. (Molecular Endocrinology 15: 1093–1103, 1986, the transcriptionally active hGR␣ was re- 2001) ported to be a single protein species of 777 amino kDa). Biochemical 94 ؍ acids (molecular mass data, obtained using various mammalian tissues INTRODUCTION and cell lines, however, have consistently revealed an additional, slightly smaller, second hGR protein The glucocorticoid receptor (GR) mediates the physi- kDa) that is not recognized ological effects of corticosteroid hormones in species 91 ؍ molecular mass) by antibodies specific for the transcriptionally in- from fish to mammals. GR is a member of the nuclear active and dominant negative, non-hormone-bind- hormone receptor superfamily of ligand-activated ing hGR isoform. We report here that when a transcription factors (1) and is essential for life (2). The single GR cDNA is transfected in COS-1 cells, or activity of the GR, as well as the progesterone (PR), transcribed and translated in vitro, two forms of androgen (AR), and mineralocorticoid receptors (MR) the receptor are observed, similar to those seen in is partially mediated through a palindromic response cells that contain endogenous GR. -
Investigation on the Behavior of Pesticides in Atmosphere
Aerosol and Air Quality Research, 11: 783–790, 2011 Copyright © Taiwan Association for Aerosol Research ISSN: 1680-8584 print / 2071-1409 online doi: 10.4209/aaqr.2010.10.0085 Investigation on the Behavior of Pesticides in Atmosphere Pasquale Avino1, Giuseppe Cinelli2, Ivan Notardonato2, Mario V. Russo2* 1 DIPIA, INAIL (ex-ISPESL), via Urbana 167, 00184 Rome, Italy 2 Faculty of Agriculture, University of Molise, via De Sanctis, Campobasso, Italy ABSTRACT Although pesticides are widely used in agriculture, they and in particular the relative residues in foodstuffs, water and atmosphere, may cause remarkable sanitary problems due to the harmful effects (carcinogenic and mutagenic effects) on the human health. In fact, their spread in waters and atmosphere can produce undesired effects on various organisms and/or water contamination. This paper shows an analytical approach based on XAD-2 adsorbent and GC analysis for evaluating the pesticide trend in atmosphere: in particular, the pesticides investigated are omethoate, dicrotofos, disulfoton, dimethoate, parathion methyl, formothion, paraoxon ethyl, malaoxon, parathion ethyl, iodofenfos and triazofos. For the analytical methodology a linearity response was obtained (r2 = 0.9988) in GC-NPD whereas the limits of detection range between 2 and 5 pg/μL in GC-NPD with a Relative Standard Deviation below 9.5. Finally, this approach has been successfully applied to real samples: the results show that dimethoate concentration decreases with increasing distance from the sampling site but it is still persistent in atmosphere after few days from the pesticide spraying. Keywords: Pesticides; XAD-2 adsorbent; GC analysis; Atmosphere; Air quality. INTRODUCTION 2009). One of the most important OP reactions is water hydrolysis.