Chicago | October 17-21 Wednesday Scienti ic Session Listings 639–830 Information at a Glance Important Phone Numbers Annual Meeting Headquarters Office Mercy Hospital Key to Poster Floor by Themes Logistics and Programming 2525 S Michigan Avenue The poster floor begins with Theme A and ends Logistics Chicago, IL 60616 with Theme H. Refer to the poster floor map at McCormick Place: Hall A, (312) 791‑6700 (312) 567‑2000 the end of this booklet. Programming Physicians Immediate Care Theme McCormick Place: Hall A, (312) 791‑6705 811 S. State Street A Development Chicago, IL 60605 B Neural Excitability, Synapses, and Glia: Volunteer Leadership Lounge (312) 566‑9510 Cellular Mechanisms McCormick Place: S505A, (312) 791‑6735 Walgreens Pharmacy C Disorders of the Nervous System General Information Booths (closest to McCormick Place) D Sensory and Motor Systems McCormick Place: 3405 S. Martin Luther King Drive E Integrative Systems: Neuroendocrinology, Gate 3 Lobby, (312) 791‑6724 Chicago, IL 60616 Neuroimmunology and Homeostatic Challenge Hall A (312) 791‑6725 (312) 326‑4064 F Cognition and Behavior Press Offices Venues G Novel Methods and Technology Development Press Room McCormick Place H History, Teaching, Public Awareness, and McCormick Place: Room S501ABC 2301 S. Martin Luther King Drive Societal Impacts in Neuroscience (312) 791‑6730 Chicago, IL 60616 Exhibit Management Fairmont Chicago, Millennium Park Hotel Note: Theme H Posters will be located in Hall A McCormick Place: Hall A, (312) 791‑6740 200 N. Columbus Drive beginning at 1 p.m. on Saturday, Oct. 17, and will Chicago, IL 60601 remain posted until 5 p.m., Sunday, Oct. 18. First Aid and Hospital Numbers (312) 565‑8000 First Aid Station McCormick Place: Level 2.5S, (312) 791‑6060 Hyatt Regency Chicago Downtown Hotel (not connected to McCormick Place) 151 E. Wacker Drive Chicago, IL 60601 (312) 565‑1234 Cover Image: This image shows the outer layers of cingulate cortex of a mouse in which eYFP is expressed in basal forebrain cholinergic neurons (green). Fibers from these neurons are distributed in the outer cortical layers among neurons that were immunostained with an antibody against NeuN (red). Bernard Bloem, Luc Schoppink, Diana C. Rotaru, Amu Faiz, Patrick Hendriks, Huibert D. Mansvelder, Wilma D.J. van de Berg, and Floris G. Wouterlood, 2014, The Journal of Neuroscience, 34(49): 16234‑16246. Complete Session Listing Wednesday AM SPECIAL LECTURE McCormick Place SYMPOSIUM McCormick Place 639. The Genetic Logic of Synapse Formation and Axon 641. Adolescent Alcohol Exposure: Long-Term Regeneration — CME Neurobiological and Behavioral Consequences — CME Wed. 8:30 AM - 9:40 AM — Hall B1 Wed. 8:30 AM - 11:00 AM — S105 Speaker: Y. JIN, Howard Hughes Med. Institute, Univ. of Chair: S. REGUNATHAN California-San Diego. Co-Chair: A. NORONHA Genetic dissection in C. elegans has long been a powerful Human studies show that morphological changes in the approach to discover the function of genes and to elucidate brain during adolescence contribute to attention, impulse the molecular and cellular network underlying how synapses control, information processing, violence, and responses to form and function. Recent technological innovation using rewards. Alcohol consumption during adolescence is highly laser surgery of single axons and in vivo imaging has also prevalent, and yet very little is known about the long-lasting made C. elegans a new model for axon regeneration. consequences. The four speakers in this symposium will Importantly, genes regulating synaptogenesis and axon describe recent findings on behavioral, cellular, molecular, regeneration are highly conserved in function across animal and structural alterations in adult animals after alcohol phyla. This lecture will focus on the key findings and discuss exposure during adolescence. implications to human health. 8:30 641.01 Introduction. 8:35 641.02 Long-lasting behavioral consequences of SYMPOSIUM McCormick Place adolescent intermittent alcohol: Exposure timing and sex matter. L. SPEAR. Binghamton Univ. 640. New Approaches to Understanding How the 9:10 641.03 Enduring effects of Adolescent Ethanol Exposure Hypothalamus Controls Adaptive and Integrative on functional circuitry of hippocampus and prefrontal cortex. — CME Behavior S. SWARTZWELDER. Duke Univ. Med. Ctr. Wed. 8:30 AM - 11:00 AM — S100A 9:45 641.04 Persistent neuroimmune gene induction: Chair: W. WISDEN Neurodegeneration and altered neurocircuitry following This symposium will present new genetic and ethological adolescent alcohol exposure. F. CREWS. Univ. of North methods that are changing researchers’ ideas about Carolina at Chapel Hill. hypothalamic function. Presenters will explore how circuitry 10:20 641.05 Adolescent alcohol drinking has enduring controlling the sleep-wake cycle has inbuilt local circadian effects on prefrontal myelin. H. RICHARDSON. Univ. of clocks; how fast and slow signalling onto hypothalamic Massachusetts Amherst. neurons allows metabolic integration; how such circuitry is also adapted to regulate emotion; and finally, speakers will 10:55 641.06 Closing Remarks. examine some of the ion channels and receptors involved in governing the activity of these circuitries. AM Wed. MINISYMPOSIUM McCormick Place 8:30 640.01 Introduction. 8:35 640.02 Local clocks in histaminergic neurons unite 642. Optogenetic Dissection of the Basal Forebrain circadian and homeostatic sleep drives. W. WISDEN. Neuromodulatory Control of Cortical Activation, Imperial Col. London. Plasticity, and Cognition — CME 9:10 640.03 Hypothalamus: Fear and feeding. C. T. GROSS. Wed. 8:30 AM - 11:00 AM — S100B EMBL. Chair: S. LIN 9:45 640.04 How channels regulate excitability in the brain’s Co-Chair: A. KEPECS clock: The suprachiasmatic nucleus. A. MEREDITH. Univ. of The basal forebrain (BF) is a major ascending arousal center Maryland Sch. of Med. and has long been implicated in cognitive functions such as attention and learning. Recent studies using optogenetics 10:20 640.05 Independent computations: Optogenetic analysis to target specific BF cell-types have led to a renaissance of peptide-small molecule co-transmission and sleep. A. in this field and are beginning to yield new insights about ADAMANTIDIS. Univ. of Bern. circuit mechanisms during behavior. This minisymposium 10:55 640.06 Closing Remarks. will discuss recent advances in the roles of BF cholinergic and non-cholinergic neurons in cognition via their dynamic modulation of cortical activity. 1:30 642.01 Introduction. 1:35 642.02 Central cholinergic neurons are rapidly recruited by reinforcement feedback. A. KEPECS. Cold Spring Harbor Lab. • Indicated a real or perceived conflict of interest, see page 161 for details. Neuroscience 2015 | Wednesday AM | 1 Indicates a high school or undergraduate student presenter. * Indicates abstract’s submitting author 1:55 642.03 Cholinergic basal forebrain input educes reward MINISYMPOSIUM McCormick Place timing in the primary visual cortex. M. G. HUSSAIN SHULER. Johns Hopkins Univ. 644. Reward-Driven Learning in Primary Sensory Cortices — CME 2:15 642.04 Cholinergic signals in mouse barrel cortex during active whisker sensing. C. C. H. PETERSEN. Brain Mind Wed. 8:30 AM - 11:00 AM — S406B Institute, Ecole Polytechnique Federale de Lausanne Chair: A. KIRKWOOD (EPFL). Maximizing reward and avoiding punishment is an important 2:35 642.05 Non-cholinergic basal forebrain neurons as a gain behavioral drive, and animals routinely learn what stimuli modulation signal for the decision-making process. S. LIN. and actions predict favorable and aversive outcomes. NIH. This panel will discuss the emerging idea that learning to recognize reward-predicting stimuli involves remodeling at 2:55 642.06 Basal forebrain circuit for brain state control. M. XU. HHMI /UC Berkeley. early stages of perception in the primary sensory cortices. Covered topics will include perceptual learning in the 3:15 642.07 Moving beyond cholinergic neurons: Control of human primary visual cortex, how cortical cells “learn” to arousal and gamma oscillations by cortically-projecting basal predict attributes of the reward, and the underlying synaptic forebrain parvalbumin neurons. R. E. BROWN. VA BHS & mechanisms. Harvard Med. Sch. 8:30 644.01 Introduction. 3:35 642.08 Closing Remarks. 8:35 644.02 The role of reward in perceptual learning. T. WATANABE. Brown Univ. MINISYMPOSIUM McCormick Place 8:55 644.03 The effect of reward on sleep consolidation involving the primary visual cortex. Y. SASAKI. Brown Univ. 643. 3D Retinal Organoids From Human Pluripotent Stem 9:15 644.04 Coding of anticipatory information in the gustatory Cells: Promise to Alleviate Blindness or Better Disease system of alert rodents. A. FONTANINI. Stony Brook Univ. Model? — CME 9:35 644.05 Eligibility traces for LTP and LTD in cortex. A. Wed. 8:30 AM - 11:00 AM — S406A KIRKWOOD. Johns Hopkins Univ. Chair: M. SEILER 9:55 644.06 Theta oscillations in visual cortex emerge with This minisymposium will bring together translational and experience to convey expected reward time and experienced basic science researchers who use pluripotent stem cells reward rate. C. L. ZOLD. Inst. de Fisiología y Biofísica and adult tissue as tools to repair vision. The promise of Bernardo Houssay. 3D retinal organoids derived from stem cells is high. What is not clear is whether this presents only a better model for 10:15 644.07 Stable reinforcement learning via temporal human retinal diseases or carries a real promise for retinal competition between LTP and LTD synaptic eligibility traces. replacement as well. Speakers will discuss the potential of H. SHOUVAL. Univ. of Texas at Houston. 3D retinal organoid approach to generate immature human 10:35 644.08 Closing Remarks. retinal sheets for vision repair. 8:30 643.01 Introduction. SPECIAL LECTURE McCormick Place 8:35 643.02 Human pluripotent stem cell-derived retinal ganglion cells: Basic science applications and translational 645. Striatal Synaptic Dysfunction in Parkinson’s and implications. J. MEYER. Indiana Univ. Huntington’s Diseases — CME 8:55 643.03 Re-engineering the retina using 3D-scaffolds. D. A. Wed. 10:00 AM - 11:10 AM — Hall B1 LAMBA. Buck Inst. for Res.