C.V. Prof. Wolf Reik

Total Page：16

File Type：pdf, Size：1020Kb

C.V. Prof. Wolf Reik Head, Laboratory of Developmental Genetics and Imprinting, The Babraham Institute, Cambridge Professor of Epigenetics, Department of Physiology, Development and Neuroscience University of Cambridge. Professor Reik is internationally distinguished for his fundamental discoveries of epigenetic mechanisms in mammalian development, physiology, genome reprogramming, and human diseases. His outstanding work led to the discovery of the molecular mechanism of genomic imprinting, and uncovered non-coding RNA and chromatin looping regulating imprinted genes, which he showed to be involved in fetal nutrition, growth, and disease. He discovered epigenetic reprogramming, including active demethylation, and showed that it affects pluripotency and lineage commitment of embryonic stem cells. He found that the environment influences epigenetic programming in embryos, with changes in gene expression persisting in adults and their offspring. Wolf's team investigates the way additional information can be added to DNA sequence in the genome through a process called epigenetics. This information, encoded by a range of processes, including chemical modification of DNA bases or alteration of proteins that bind to DNA, can be altered during the life of an organism. Wolf is interested in the processes of epigenetic reprogramming during early embryo development that allow germline cells to be directed to become adult cells in mammalian animals. As a member of Associate Faculty he is collaborating with Sanger Institute scientists to discover the biology and pathology of epigenetic reprogramming. As part of this research, he is working to develop new sequencing approaches that will capture the range of DNA modifications that are present. Wolf is based at the neighbouring Babraham Institute where he is Head of the Epigenetics Programme; he is also honorary Professor of Epigenetics at the University of Cambridge. He obtained his MD from the University of Hamburg, and carried out postdoctoral work in Cambridge, before becoming a Fellow of the Lister Institute of Preventive Medicine and subsequently Head of Programme at the Babraham Institute. He and his collaborators discovered epigenetic reprogramming in mammalian development, and are elucidating the mechanisms of demethylation of DNA and the biological significance of reprogramming in normal development, stem cell function, and in disease. He was awarded the Wellcome Prize in Physiology and is a Fellow of the Royal Society, the Academy of Medical Sciences, and a Member of EMBO and the Academia Europaea. .

Copy Link

Recommended publications

The for Report 07-08
THE CENTER FOR INTEGRATIVE GENOMICS REPORT 07-08 www.unil.ch/cig Table of Contents INTRODUCTION 2 The CIG at a glance 2 The CIG Scientific Advisory Committee 3 Message from the Director 4 RESEARCH 6 Richard Benton Chemosensory perception in Drosophila: from genes to behaviour 8 Béatrice Desvergne Networking activity of PPARs during development and in adult metabolic homeostasis 10 Christian Fankhauser The effects of light on plant growth and development 12 Paul Franken Genetics and energetics of sleep homeostasis and circadian rhythms 14 Nouria Hernandez Mechanisms of basal and regulated RNA polymerase II and III transcription of ncRNA in mammalian cells 16 Winship Herr Regulation of cell proliferation 18 Henrik Kaessmann Mammalian evolutionary genomics 20 Sophie Martin Molecular mechanisms of cell polarization 22 Liliane Michalik Transcriptional control of tissue repair and angiogenesis 24 Alexandre Reymond Genome structure and expression 26 Andrzej Stasiak Functional transitions of DNA structure 28 Mehdi Tafti Genetics of sleep and the sleep EEG 30 Bernard Thorens Molecular and physiological analysis of energy homeostasis in health and disease 32 Walter Wahli The multifaceted roles of PPARs 34 Other groups at the Génopode 37 CORE FACILITIES 40 Lausanne DNA Array Facility (DAFL) 42 Protein Analysis Facility (PAF) 44 Core facilities associated with the CIG 46 EDUCATION 48 Courses and lectures given by CIG members 50 Doing a PhD at the CIG 52 Seminars and symposia 54 The CIG annual retreat 62 The CIG and the public 63 Artist in residence at the CIG 63 PEOPLE 64 1 Introduction The Center for IntegratiVE Genomics (CIG) at A glance The Center for Integrative Genomics (CIG) is the newest depart- ment of the Faculty of Biology and Medicine of the University of Lausanne (UNIL).
[Show full text]
Epigenetics, Obesity and Metabolism
Epigenetics, Obesity and Metabolism Wellcome Genome Campus Conference Centre Hinxton, Cambridge, UK October 11-14, 2015 Conference Program Sunday, October 11 14:00 – 15:00 Registration 15:00 Welcome and introductions Nessa Carey & Wolf Reik Session 1: Introduction into the three fields Chair: Wolf Reik 15:00 – 15:45 Adrian Bird (University of Edinburgh, UK) DNA methylation and the brain 15:45 – 16:30 Stephen O'Rahilly (University of Cambridge, UK) Metabolic Disease: lessons from human genetics 16:30 – 17:15 Jens Bruning (Max Planck Institute, Germany) Neonatal insulin action impairs hypothalamic neurocircuit formation in response to maternal high-fat feeding 17:15 – 17:30 Abcam 17:30 – 19:30 Poster Session and welcome reception Dinner Monday, October 12 07:30 – 09:00 Breakfast Session 2: How circadian rhythms link with, and are linked by, the three topics Chair: Stephen O’Rahily and Jens Bruning 09:30 – 10:05 Wolfgang Wagner (Helmholtz Institute for Biomedical Engineering, Germany) DNA Methylation changes in replicative senescence and aging 10:05 – 10:40 Sung Hee Baek (Seoul National University, South Korea) Phosphorylation of LSD1 by PKCalpha is crucial for circadian rhythmicity and phase resetting 10:40 – 10:55 Guillaume Rey (University of Cambridge, UK) Central carbon metabolism regulates circadian oscillations Break 11:30 – 12:05 Andrew Loudon (University of Manchester, UK) The generation of the seasonal rhythm: role of circadian clock genes and epigenetics in the circannual clockwork 12:05 – 12:40 Ueli Schibler (University of Geneva,
[Show full text]
A N N U a L R E P O R T 2 0
0 1 0 2 Acknowledgements T R HFSPO is grateful for the support of the following organizations: O P Australia E R National Health and Medical Research Council (NHMRC) L Canada A Canadian Institute of Health Research (CIHR) U Natural Sciences and Engineering Research Council (NSERC) N European Union N European Commission - A Directorate General Information Society (DG INFSO) European Commission - Directorate General Research (DG RESEARCH) France Communauté Urbaine de Strasbourg (CUS) Ministère des Affaires Etrangères et Européennes (MAEE) Ministère de l’Enseignement Supérieur et de la Recherche (MESR) Région Alsace Germany Federal Ministry of Education and Research (BMBF) India Department of Biotechnology (DBT), Ministry of Science and Technology Italy Ministry of Education, University and Research (CNR) Japan Ministry for Economy, Trade and Industry (METI) Ministry of Education, Culture, Sports, Science and Technology (MEXT) Republic of Korea Ministry of Education, Science and Technology (MEST) New Zealand Health Research Council (HRC) Norway Research Council of Norway (RCN) Switzerland State Secretariat for Education and Research (SER) United Kingdom The International Human Frontier Science Biotechnology and Biological Sciences Research Program Organization (HFSPO) Council (BBSRC) 12 quai Saint Jean - BP 10034 Medical Research Council (MRC) 67080 Strasbourg CEDEX - France Fax. +33 (0)3 88 32 88 97 United States of America e-mail: [email protected] National Institutes of Health (NIH) Web site: www.hfsp.org National Science Foundation (NSF) Japanese web site: http://jhfsp.jsf.or.jp HUMAN FRONTIER SCIENCE PROGRAM The Human Frontier Science Program is unique, supporting international collaboration to undertake innovative, risky, basic research at the frontiers of the life sciences.
[Show full text]
Highly Multiplexed Spatially Resolved Gene Expression Profiling of Mouse Organogenesis
bioRxiv preprint doi: https://doi.org/10.1101/2020.11.20.391896; this version posted November 21, 2020. The copyright holder for this preprint (which was not certified by peer review) is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under aCC-BY-NC 4.0 International license. Highly multiplexed spatially resolved gene expression profiling of mouse organogenesis T. Lohoff1,2,3*, S. Ghazanfar4*, A. Missarova4,5‡, N. Koulena6‡, N. Pierson6‡, J.A. Griffiths4^, E.S. Bardot7, C.-H.L. Eng6, R.C.V. Tyser8, R. Argelaguet5, C. Guibentif1,9,10, S. Srinivas8, J. Briscoe11, B.D. Simons1,12,13, A.-K. Hadjantonakis7, B. Göttgens1,9, W. Reik1,3,14,15†, J. Nichols1,2†, L. Cai6†, J.C. Marioni4,5,15†* 1 Wellcome-Medical Research Council Cambridge Stem Cell Institute, University of Cambridge, Cambridge, UK 2 Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, UK 3 Epigenetics Programme, Babraham Institute, Cambridge, UK 4 Cancer Research UK Cambridge Institute, University of Cambridge, Cambridge, UK 5 European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Genome Campus, Cambridge, UK 6 Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA, USA 7 Developmental Biology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY, USA 8 Department of Physiology Anatomy and Genetics, University of Oxford, Oxford, UK 9 Department of Haematology, University of
[Show full text]
The Sixth Weissenburg Symposium September 01 - 04, 2021 Venue: Kulturzentrum Karmeliterkirche, Weissenburg in Bayern, Germany
In times of crisis, optimism and caution will be of the essence The Sixth Weissenburg Symposium September 01 - 04, 2021 Venue: Kulturzentrum Karmeliterkirche, Weissenburg in Bayern, Germany “Genome-wide Epigenetic Profiles” Dear friends of the Weissenburg Symposia, As of today, Thursday, July 22, 2021, the statistics of Covid-19 cases in Germany and Weissenburg are the following: The incidence of cases per 100.000 inhabitants during the past 7 days has been 12.2 and 5.3, respectively. Vaccination update: 60.4 % of the population in Germany have been vaccinated once, 48 % twice. With the obvious proviso that predictions about the state of the pandemic in September 2021 are impossible to make, we decided to schedule the Weissenburg Symposium September 01 to 04, 2021. Please, be assured that, should Covid-19 conditions deteriorate between now and around the end of August, we would have to postpone or cancel the date of the meeting again. Lectures will begin on Wednesday September 01, 2021 at 9:00 o’clock AM.. List of Speakers and (Preliminary) Lecture Titles Thomas R. Broker, University of Alabama, Birmingham – [email protected] Clonal selection for a single locus of transcriptionally active HPV oncogenes in cancers involving DNA methylation-mediated silencing. Louise T. Chow, University of Alabama, Birmingham – Histone deacetylase inhibitors abrogate HPV DNA replicative amplification and cause apoptosis in cervical cancer xenografts and organoids. [email protected] *Michelle Débatisse, Institut Gustave Roussy, Paris – [email protected] Title pending. *Walter Doerfler, FAU Erlangen-Nürnberg, Institute of Genetics, Cologne – [email protected] Epigenetic consequences of foreign DNA insertions into mammalian genomes.
[Show full text]
Transcription and Histone Methylation Changes Correlate with Imprint Acquisition in Male Germ Cells
The EMBO Journal (2012) 31, 606–615 | & 2012 European Molecular Biology Organization | All Rights Reserved 0261-4189/12 www.embojournal.org TTHEH E EEMBOMBO JJOURNALOURN AL Transcription and histone methylation changes correlate with imprint acquisition in male germ cells Amandine Henckel1, Karim Chebli, known why some ICRs acquire DNA methylation imprints in Satya K Kota, Philippe Arnaud2,3,* and the female germ line, while others become methylated Robert Feil3,* speciﬁcally in the male germ line. However, in both the germ lines de-novo DNA methyltransferase DNMT3A is Institute of Molecular Genetics (IGMM), CNRS, Universities of et al et al Montpellier I and II, Montpellier, France involved in imprint acquisition (Kaneda , 2004; Kato , 2007). The related DNMT3L protein can form complexes with Genomic imprinting in mammals is controlled by DNA DNMT3A and plays an essential role in imprint acquisition as methylation imprints that are acquired in the gametes, at well (Bourc’his et al, 2001; Hata et al, 2002; Kato et al, 2007). essential sequence elements called ‘imprinting control Interestingly, DNMT3L can bind to histone H3 in vitro, but H3 regions’ (ICRs). What signals paternal imprint acquisition lysine-4 dimethylation, and in particular H3-K4 trimethyla- in male germ cells remains unknown. To address this tion (H3K4me3), was found to prevent its association with question, we explored histone methylation at ICRs in chromatin (Ooi et al, 2007). Recent studies show that mouse primordial germ cells (PGCs). By 13.5 days post DNMT3A itself is also sensitive to the H3 lysine-4 methyla- coitum (d.p.c.), H3 lysine-9 and H4 lysine-20 trimethyla- tion status.
[Show full text]
Scientific Report 2019-2020
CBM Scientific Report 2019-2020 CENTRO DE BIOLOGÍA MOLECULAR SEVERO OCHOA 2 3 CENTRO DE BIOLOGÍA MOLECULAR SEVERO OCHOA C/ Nicolás Cabrera, 1 Campus de la Universidad Autónoma de Madrid 28049 Madrid Tel.: (+34) 91 196 4401 www.cbm.uam.es INDEX DIRECTOR´S REMARK 8 THE CBM IN A NUTSHELL 10-21 ERC PROJECTS 21 COVID-19 PROJECTS 22-29 GENOME DYNAMICS AND FUNCTION 30 GENOME DECODING 32 UGO BASTOLLA 34 COMPUTATIONAL BIOLOGY AND BIOINFORMATICS JOSÉ FERNÁNDEZ PIQUERAS / JAVIER SANTOS 36 GENETICS AND CELL BIOLOGY OF CANCER: T-CELL LYMPHOBLASTIC NEOPLASMS CRISANTO GUTIERREZ 38 CELL DIVISION, GENOME REPLICATION AND CHROMATIN ENCARNACIÓN MARTÍNEZ-SALAS 40 INTERNAL INITIATION OF TRANSLATION IN EUKARYOTIC mRNAs SANTIAGO RAMÓN 42 STRUCTURE AND FUNCTION OF MACROMOLECULAR COMPLEXES JOSÉ MARÍA REQUENA 44 REGULATION OF GENE EXPRESSION IN LEISHMANIA IVÁN VENTOSO / CÉSAR DE HARO/ JUAN JOSÉ BERLANGA / MIGUEL ÁNGEL RODRÍGUEZ 46 REGULATION OF mRNA TRANSLATION IN EUKARYOTES AND ITS IMPLICATIONS FOR ORGANISMAL LIFE GENOME MAINTENANCE AND INSTABILITY 48 LUIS BLANCO 50 GENOME MAINTENANCE AND VARIABILITY: ENZYMOLOGY OF DNA REPLICATION AND REPAIR MIGUEL DE VEGA 52 MAINTENANCE OF BACTERIAL GENOME STABILITY MARÍA GÓMEZ 54 FUNCTIONAL ORGANIZATION OF THE MAMMALIAN GENOME EMILIO LECONA 56 CHROMATIN, CANCER AND THE UBIQUITIN SYSTEM MARGARITA SALAS GROUP 58 REPLICATION OF BACTERIOPHAGE Ø29 DNA JOSÉ ANTONIO TERCERO 60 CHROMOSOME REPLICATION AND GENOME STABILITY 2 3 TISSUE AND ORGAN HOMEOSTASIS 62 CELL ARCHITECTURE & ORGANOGENESIS 64 MIGUEL ÁNGEL ALONSO 66 CELL POLARITY PAOLA
[Show full text]
Epigénétique, Reprogrammation Et Développement
Epigénétique, reprogrammation et développement Epigenetics, Reprogramming and Development COLLOQUE DE L’ACADÉMIE DES SCIENCES 14-15 SEPTEMBRE 2010 à l’Institut de France Grande salle des séances 23 quai de Conti - 75006 Paris Crédit photo : Piero d’Houin Comité scientifique / Scientific Committee Présidents Jean-François Bach Secrétaire perpétuel de l’Académie des sciences, Membre de l’Académie nationale de médecine et Marcel Méchali Membre de l’Académie des sciences avec Pascale Cossart et Mosche Yaniv, Membres de l’Académie des sciences Avec le soutien de / with the sponsoring of [23/07/2010] Programme 8h30 – 8h45 Accueil 8h45 – 9h10 Ouverture du Colloque / Welcome Address Jean-François Bach, Secrétaire perpétuel de l’Académie des sciences Introduction : Marcel Méchali, Membre de l’Académie des sciences, Institut de Génétique Humaine, Montpellier, CNRS Tuesday 14 September / Mardi 14 septembre Chromatin - Nucleus 09h10 – 09h45 Variation on the theme of chromatin assembly Geneviève Almouzni, Institut Curie, UMR 218 CNRS, Paris, France 09h45 – 10h20 The principal chromatin types in Drosophila Bas van Steensel, Division of Gene Regulation, Netherlands Cancer Institute, Amsterdam, The Netherlands 10h20 – 10h50 Coffee break 10h50 – 11h25 Transcription and spatial organization of the genome Peter Fraser, Laboratory of Chromatin and Gene Expression, The Babraham Institute, Cambridge, UK 11h25 – 12h00 Epigenetic regulation of development by polycomb proteins Giacomo Cavalli, Institut de Génétique Humaine, Montpellier, CNRS, France 12h00: Lunch
[Show full text]
Acknowledgment of Reviewers, 2009
Proceedings of the National Academy ofPNAS Sciences of the United States of America www.pnas.org Acknowledgment of Reviewers, 2009 The PNAS editors would like to thank all the individuals who dedicated their considerable time and expertise to the journal by serving as reviewers in 2009. Their generous contribution is deeply appreciated. A R. Alison Adcock Schahram Akbarian Paul Allen Lauren Ancel Meyers Duur Aanen Lia Addadi Brian Akerley Phillip Allen Robin Anders Lucien Aarden John Adelman Joshua Akey Fred Allendorf Jens Andersen Ruben Abagayan Zach Adelman Anna Akhmanova Robert Aller Olaf Andersen Alejandro Aballay Sarah Ades Eduard Akhunov Thorsten Allers Richard Andersen Cory Abate-Shen Stuart B. Adler Huda Akil Stefano Allesina Robert Andersen Abul Abbas Ralph Adolphs Shizuo Akira Richard Alley Adam Anderson Jonathan Abbatt Markus Aebi Gustav Akk Mark Alliegro Daniel Anderson Patrick Abbot Ueli Aebi Mikael Akke David Allison David Anderson Geoffrey Abbott Peter Aerts Armen Akopian Jeremy Allison Deborah Anderson L. Abbott Markus Affolter David Alais John Allman Gary Anderson Larry Abbott Pavel Afonine Eric Alani Laura Almasy James Anderson Akio Abe Jeffrey Agar Balbino Alarcon Osborne Almeida John Anderson Stephen Abedon Bharat Aggarwal McEwan Alastair Grac¸a Almeida-Porada Kathryn Anderson Steffen Abel John Aggleton Mikko Alava Genevieve Almouzni Mark Anderson Eugene Agichtein Christopher Albanese Emad Alnemri Richard Anderson Ted Abel Xabier Agirrezabala Birgit Alber Costica Aloman Robert P. Anderson Asa Abeliovich Ariel Agmon Tom Alber Jose´ Alonso Timothy Anderson Birgit Abler Noe¨l Agne`s Mark Albers Carlos Alonso-Alvarez Inger Andersson Robert Abraham Vladimir Agranovich Matthew Albert Suzanne Alonzo Tommy Andersson Wickliffe Abraham Anurag Agrawal Kurt Albertine Carlos Alos-Ferrer Masami Ando Charles Abrams Arun Agrawal Susan Alberts Seth Alper Tadashi Andoh Peter Abrams Rajendra Agrawal Adriana Albini Margaret Altemus Jose Andrade, Jr.
[Show full text]
Biologist-Archive
TheTHE SOCIETY OF BIOLOGY MAGAZINE ■ ISSN 0006-3347Biologist ■ SOCIETYOFBIOLOGY.ORG VOL 61 NO 1 ■ FEB/MAR 2014 THE FUTURE OF FUEL Could biofuel from algae reduce our need for oil? URBAN ENVIRONMENT MICROBIOTA INTERVIEW DEEP ROOTS GUT INSTINCT AGE OF SUCCESS Saving trees during The body's bacteria and Linda Partridge on the urban development its impact on our health biology of ageing New from Garland Science EPIGENETICS Lyle Armstrong The concept of epigenetics has been about since the 1940s, but it is only in the last 10 years that research has shown just how wide-ranging its effects are. It is now a widely-used term, but there is still confusion surrounding what it actually is and does. Epigenetics is a new textbook that brings together the structure and machinery of epigenetic modification, how epigenetic modification controls cellular functions, and the evidence for the relationship between epigenetics and disease. It is a valuable source of information about all aspects of the subject for undergraduate students, graduate students, and professionals. Topics Include: • The two forms of epigenetic modification, DNA methylation Paperback • £45.00 and histone acetylation, and how they take place. 2013 * 978-0-8153-6511-2 • How epigenetics controls cell function, including cellular 300pp • 150 illus differentiation and the role of epigenetics in stem cells. • The role of epigenetics in disease, including cancer and mental health, where there is clear evidence of epigenetic Contents: involvement. Chapter 1. Introduction to the Study of EpigeneticsChapter 2. The Basis of the Transcription Process Chapter 3. DNA Packaging and Chromatin Architecture Chapter 4.
[Show full text]
Academia Europaea Directory 2014
Academia Europaea Directory 2014 Academia Europaea Directory 2014 The Academy of Europe Contents Section A President’s Introduction .....................................................................................2 History and Mission .............................................................................................3 Structure and contacts .......................................................................................4 Russia prizes ...........................................................................................................5 Burgen Scholars ....................................................................................................5 Honorary Membership .......................................................................................5 Gold Medal .............................................................................................................5 Erasmus Medal ......................................................................................................6 AE-INFO.org ............................................................................................................7 Composition of Board and Council ................................................................7 List of Sections and chairs .................................................................................8 European Review online access ......................................................................9 Published by Academia Europaea Section B 4th floor, 21 Albemarle Street, London W1S 4HS Telephone:
[Show full text]
Transcription and Histone Methylation Changes Correlate with Imprint Acquisition in Male Germ Cells
The EMBO Journal (2011), 1–10 | & 2011 European Molecular Biology Organization | All Rights Reserved 0261-4189/11 www.embojournal.org TTHEH E EEMBOMBO JJOURNALOURN AL Transcription and histone methylation changes correlate with imprint acquisition in male germ cells Amandine Henckel1, Karim Chebli, known why some ICRs acquire DNA methylation imprints in Satya K Kota, Philippe Arnaud2,3,* and the female germ line, while others become methylated Robert Feil3,* speciﬁcally in the male germ line. However, in both the germ lines de-novo DNA methyltransferase DNMT3A is Institute of Molecular Genetics (IGMM), CNRS, Universities of et al et al Montpellier I and II, Montpellier, France involved in imprint acquisition (Kaneda , 2004; Kato , 2007). The related DNMT3L protein can form complexes with Genomic imprinting in mammals is controlled by DNA DNMT3A and plays an essential role in imprint acquisition as methylation imprints that are acquired in the gametes, at well (Bourc’his et al, 2001; Hata et al, 2002; Kato et al, 2007). essential sequence elements called ‘imprinting control Interestingly, DNMT3L can bind to histone H3 in vitro,butH3 regions’ (ICRs). What signals paternal imprint acquisition lysine-4 dimethylation, and in particular H3-K4 trimethyla- in male germ cells remains unknown. To address this tion (H3K4me3), was found to prevent its association with question, we explored histone methylation at ICRs in chromatin (Ooi et al, 2007). Recent studies show that mouse primordial germ cells (PGCs). By 13.5 days post DNMT3A itself is also sensitive to the H3 lysine-4 methyla- coitum (d.p.c.), H3 lysine-9 and H4 lysine-20 trimethyla- tion status.
[Show full text]