Annual Report and Accounts
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Mothers in Science
The aim of this book is to illustrate, graphically, that it is perfectly possible to combine a successful and fulfilling career in research science with motherhood, and that there are no rules about how to do this. On each page you will find a timeline showing on one side, the career path of a research group leader in academic science, and on the other side, important events in her family life. Each contributor has also provided a brief text about their research and about how they have combined their career and family commitments. This project was funded by a Rosalind Franklin Award from the Royal Society 1 Foreword It is well known that women are under-represented in careers in These rules are part of a much wider mythology among scientists of science. In academia, considerable attention has been focused on the both genders at the PhD and post-doctoral stages in their careers. paucity of women at lecturer level, and the even more lamentable The myths bubble up from the combination of two aspects of the state of affairs at more senior levels. The academic career path has academic science environment. First, a quick look at the numbers a long apprenticeship. Typically there is an undergraduate degree, immediately shows that there are far fewer lectureship positions followed by a PhD, then some post-doctoral research contracts and than qualified candidates to fill them. Second, the mentors of early research fellowships, and then finally a more stable lectureship or career researchers are academic scientists who have successfully permanent research leader position, with promotion on up the made the transition to lectureships and beyond. -
Female Fellows of the Royal Society
Female Fellows of the Royal Society Professor Jan Anderson FRS [1996] Professor Ruth Lynden-Bell FRS [2006] Professor Judith Armitage FRS [2013] Dr Mary Lyon FRS [1973] Professor Frances Ashcroft FMedSci FRS [1999] Professor Georgina Mace CBE FRS [2002] Professor Gillian Bates FMedSci FRS [2007] Professor Trudy Mackay FRS [2006] Professor Jean Beggs CBE FRS [1998] Professor Enid MacRobbie FRS [1991] Dame Jocelyn Bell Burnell DBE FRS [2003] Dr Philippa Marrack FMedSci FRS [1997] Dame Valerie Beral DBE FMedSci FRS [2006] Professor Dusa McDuff FRS [1994] Dr Mariann Bienz FMedSci FRS [2003] Professor Angela McLean FRS [2009] Professor Elizabeth Blackburn AC FRS [1992] Professor Anne Mills FMedSci FRS [2013] Professor Andrea Brand FMedSci FRS [2010] Professor Brenda Milner CC FRS [1979] Professor Eleanor Burbidge FRS [1964] Dr Anne O'Garra FMedSci FRS [2008] Professor Eleanor Campbell FRS [2010] Dame Bridget Ogilvie AC DBE FMedSci FRS [2003] Professor Doreen Cantrell FMedSci FRS [2011] Baroness Onora O'Neill * CBE FBA FMedSci FRS [2007] Professor Lorna Casselton CBE FRS [1999] Dame Linda Partridge DBE FMedSci FRS [1996] Professor Deborah Charlesworth FRS [2005] Dr Barbara Pearse FRS [1988] Professor Jennifer Clack FRS [2009] Professor Fiona Powrie FRS [2011] Professor Nicola Clayton FRS [2010] Professor Susan Rees FRS [2002] Professor Suzanne Cory AC FRS [1992] Professor Daniela Rhodes FRS [2007] Dame Kay Davies DBE FMedSci FRS [2003] Professor Elizabeth Robertson FRS [2003] Professor Caroline Dean OBE FRS [2004] Dame Carol Robinson DBE FMedSci -
The for Report 07-08
THE CENTER FOR INTEGRATIVE GENOMICS REPORT 07-08 www.unil.ch/cig Table of Contents INTRODUCTION 2 The CIG at a glance 2 The CIG Scientific Advisory Committee 3 Message from the Director 4 RESEARCH 6 Richard Benton Chemosensory perception in Drosophila: from genes to behaviour 8 Béatrice Desvergne Networking activity of PPARs during development and in adult metabolic homeostasis 10 Christian Fankhauser The effects of light on plant growth and development 12 Paul Franken Genetics and energetics of sleep homeostasis and circadian rhythms 14 Nouria Hernandez Mechanisms of basal and regulated RNA polymerase II and III transcription of ncRNA in mammalian cells 16 Winship Herr Regulation of cell proliferation 18 Henrik Kaessmann Mammalian evolutionary genomics 20 Sophie Martin Molecular mechanisms of cell polarization 22 Liliane Michalik Transcriptional control of tissue repair and angiogenesis 24 Alexandre Reymond Genome structure and expression 26 Andrzej Stasiak Functional transitions of DNA structure 28 Mehdi Tafti Genetics of sleep and the sleep EEG 30 Bernard Thorens Molecular and physiological analysis of energy homeostasis in health and disease 32 Walter Wahli The multifaceted roles of PPARs 34 Other groups at the Génopode 37 CORE FACILITIES 40 Lausanne DNA Array Facility (DAFL) 42 Protein Analysis Facility (PAF) 44 Core facilities associated with the CIG 46 EDUCATION 48 Courses and lectures given by CIG members 50 Doing a PhD at the CIG 52 Seminars and symposia 54 The CIG annual retreat 62 The CIG and the public 63 Artist in residence at the CIG 63 PEOPLE 64 1 Introduction The Center for IntegratiVE Genomics (CIG) at A glance The Center for Integrative Genomics (CIG) is the newest depart- ment of the Faculty of Biology and Medicine of the University of Lausanne (UNIL). -
Expression of the Short Stature Homeobox Gene Shox Is Restricted by Proximal and Distal Signals in Chick Limb Buds and Affects the Length of Skeletal Elements
Developmental Biology 298 (2006) 585–596 www.elsevier.com/locate/ydbio Expression of the short stature homeobox gene Shox is restricted by proximal and distal signals in chick limb buds and affects the length of skeletal elements Eva Tiecke a, Fiona Bangs a, Rudiger Blaschke b, Elizabeth R. Farrell a, ⁎ Gudrun Rappold b, Cheryll Tickle a, a Division of Cell and Developmental Biology, School of Life Sciences, University of Dundee, Dow Street, Dundee, DD1 5EH, UK b Department of Human Molecular Genetics, University of Heidelberg, Im Neuenheimer Feld 366, D-69120 Heidelberg, Germany Received for publication 6 June 2006; accepted 10 July 2006 Available online 12 July 2006 Abstract SHOX is a homeobox-containing gene, highly conserved among species as diverse as fish, chicken and humans. SHOX gene mutations have been shown to cause idiopathic short stature and skeletal malformations frequently observed in human patients with Turner, Leri–Weill and Langer syndromes. We cloned the chicken orthologue of SHOX, studied its expression pattern and compared this with expression of the highly related Shox2. Shox is expressed in central regions of early chick limb buds and proximal two thirds of later limbs, whereas Shox2 is expressed more posteriorly in the proximal third of the limb bud. Shox expression is inhibited distally by signals from the apical ectodermal ridge, both Fgfs and Bmps, and proximally by retinoic acid signaling. We tested Shox functions by overexpression in embryos and micromass cultures. Shox- infected chick limbs had normal proximo-distal patterning but the length of skeletal elements was consistently increased. Primary chick limb bud cell cultures infected with Shox showed an initial increase in cartilage nodules but these did not enlarge. -
Annual Review 2019 & Vision for 2020
Daphne Jackson Trust Annual Review 2019 1 Changing Landscapes Annual Review 2019 & vision for 2020 Daphne Jackson Trust Annual Review 2019 3 Welcome from Teresa Anderson Chair of the Daphne Jackson Trust When we chose the working title punch well above its weight, as a small ever faced. Recent world events have of ‘Changing Landscapes’ for this charity, which is really making a big taught us that science and innovation annual review, we didn’t realise difference. The Fellowships offered by offer hope and optimism. Now is the quite how well this title would the Trust are still quite unlike any other time to recognise this and magnify our describe the situation we are currently available in either academia or impact by collaborating across disciplines, all in as this is finalised. The main in industry, and offer the best chance of institutions and countries. The work of purpose of this review, though, is success for a returning researcher. the Daphne Jackson Trust must be part to highlight the tremendous success of this. With everyone’s commitment I of the Trust in 2019, even in the It is undoubtedly a challenging time for am confident we will succeed and prosper. midst of the uncertainties caused researchers and institutions; uncertainty by Brexit, which have now, in 2020, exists across the higher education and been eclipsed by the unprecedented the UK science and research sectors. changes and challenges from the It’s important for all of us to continue COVID-19 pandemic. We will then to collaborate with our networks and Contents colleagues around the world. -
Principles of Development Lewis Wolpert
Principles of development lewis wolpert Continue The process of biological development is an amazing feat of tightly regulated cellular behavior - differentiation, movement and growth - powerful enough to lead to the appearance of a very complex living organism from a single cell, a fertilized egg. The principles of development clearly illustrate the universal principles governing this development process in a concise and accessible style. Written by two respected and influential development biologists, Lewis Volpert and Sheryl Tickle, it focuses on the systems that best illuminate the general principles covered by the text and avoids suppressing the reader with encyclopedic details. With co-authors whose experience spans discipline, The Principles of Development combines the careful study of the subject with ideas from some of the world's pioneers of research in development biology, guiding the student from the basics to the latest discoveries in the field. The Internet Resource Center Internet Resource Center to accompany the Principles of Development features For registered adopters of text: Electronic works of art: Figures from the book are available for download, for use in lectures. Journal Club: Proposed scientific papers and discussion related to the topics presented in the book direct the process of learning from the scientific literature. PowerPoint numbers: Figures inserted into PowerPoint for use in handouts and presentations. For students: Web links and web activities: Recommended websites related to each chapter guide students to further sources of information each accompanied by a brief overview of how the source can help with their research and thought issue to help think about the underlying issues. -
20 October 2015
20 October 2015 Agenda The subject of the meeting of the All-Party Parliamentary University Group is Universities and Europe: why EU membership and reform matter. 6.00pm Dr Roberta Blackman-Woods MP, Chair of the All-Party Parliamentary University Group, welcome and introductions. 6.05pm Professor Julia Goodfellow, Vice-Chancellor, University of Kent and President, Universities UK 6.15pm Neil Carmichael MP, Chair, Conservative Europe Group 6.25pm Pawel Swidlicki, Policy Analyst, Open Europe 6.40pm Questions, comments, and discussion with university leaders, MPs and Peers. 7.30pm Speaker meeting concludes. Guests move to Dining Room B for dinner. 1 Speaker biographies Professor Julia Goodfellow Professor Dame Julia Goodfellow has been Vice- Chancellor of the University of Kent since 2007. She was appointed to both the Science and Technology Facilities Council and Prime Minister’s Council for Science and Technology in 2011. She took up the post of President of Universities UK in August 2015. Julia’s scientific studies pioneered the use of computational methods to study the structures of large biologically important molecules. She became Professor of Biomolecular Sciences in 1995 at Birkbeck, University of London, where she was appointed Vice-Master in 1998. Before joining Kent, Julia was Chief Executive of the Biotechnology and Biological Sciences Research Council (BBSRC). Neil Carmichael MP Neil was first elected to Parliament in 2010 and serves as MP for Stroud, re-elected this May with an increased majority. He was elected to Chair of the Education Select Committee in June 2015, having served as a member of the Education Select Committee between 2010 and 2015. -
Epigenetics, Obesity and Metabolism
Epigenetics, Obesity and Metabolism Wellcome Genome Campus Conference Centre Hinxton, Cambridge, UK October 11-14, 2015 Conference Program Sunday, October 11 14:00 – 15:00 Registration 15:00 Welcome and introductions Nessa Carey & Wolf Reik Session 1: Introduction into the three fields Chair: Wolf Reik 15:00 – 15:45 Adrian Bird (University of Edinburgh, UK) DNA methylation and the brain 15:45 – 16:30 Stephen O'Rahilly (University of Cambridge, UK) Metabolic Disease: lessons from human genetics 16:30 – 17:15 Jens Bruning (Max Planck Institute, Germany) Neonatal insulin action impairs hypothalamic neurocircuit formation in response to maternal high-fat feeding 17:15 – 17:30 Abcam 17:30 – 19:30 Poster Session and welcome reception Dinner Monday, October 12 07:30 – 09:00 Breakfast Session 2: How circadian rhythms link with, and are linked by, the three topics Chair: Stephen O’Rahily and Jens Bruning 09:30 – 10:05 Wolfgang Wagner (Helmholtz Institute for Biomedical Engineering, Germany) DNA Methylation changes in replicative senescence and aging 10:05 – 10:40 Sung Hee Baek (Seoul National University, South Korea) Phosphorylation of LSD1 by PKCalpha is crucial for circadian rhythmicity and phase resetting 10:40 – 10:55 Guillaume Rey (University of Cambridge, UK) Central carbon metabolism regulates circadian oscillations Break 11:30 – 12:05 Andrew Loudon (University of Manchester, UK) The generation of the seasonal rhythm: role of circadian clock genes and epigenetics in the circannual clockwork 12:05 – 12:40 Ueli Schibler (University of Geneva, -
Smutty Alchemy
University of Calgary PRISM: University of Calgary's Digital Repository Graduate Studies The Vault: Electronic Theses and Dissertations 2021-01-18 Smutty Alchemy Smith, Mallory E. Land Smith, M. E. L. (2021). Smutty Alchemy (Unpublished doctoral thesis). University of Calgary, Calgary, AB. http://hdl.handle.net/1880/113019 doctoral thesis University of Calgary graduate students retain copyright ownership and moral rights for their thesis. You may use this material in any way that is permitted by the Copyright Act or through licensing that has been assigned to the document. For uses that are not allowable under copyright legislation or licensing, you are required to seek permission. Downloaded from PRISM: https://prism.ucalgary.ca UNIVERSITY OF CALGARY Smutty Alchemy by Mallory E. Land Smith A THESIS SUBMITTED TO THE FACULTY OF GRADUATE STUDIES IN PARTIAL FULFILMENT OF THE REQUIREMENTS FOR THE DEGREE OF DOCTOR OF PHILOSOPHY GRADUATE PROGRAM IN ENGLISH CALGARY, ALBERTA JANUARY, 2021 © Mallory E. Land Smith 2021 MELS ii Abstract Sina Queyras, in the essay “Lyric Conceptualism: A Manifesto in Progress,” describes the Lyric Conceptualist as a poet capable of recognizing the effects of disparate movements and employing a variety of lyric, conceptual, and language poetry techniques to continue to innovate in poetry without dismissing the work of other schools of poetic thought. Queyras sees the lyric conceptualist as an artistic curator who collects, modifies, selects, synthesizes, and adapts, to create verse that is both conceptual and accessible, using relevant materials and techniques from the past and present. This dissertation responds to Queyras’s idea with a collection of original poems in the lyric conceptualist mode, supported by a critical exegesis of that work. -
A N N U a L R E P O R T 2 0
0 1 0 2 Acknowledgements T R HFSPO is grateful for the support of the following organizations: O P Australia E R National Health and Medical Research Council (NHMRC) L Canada A Canadian Institute of Health Research (CIHR) U Natural Sciences and Engineering Research Council (NSERC) N European Union N European Commission - A Directorate General Information Society (DG INFSO) European Commission - Directorate General Research (DG RESEARCH) France Communauté Urbaine de Strasbourg (CUS) Ministère des Affaires Etrangères et Européennes (MAEE) Ministère de l’Enseignement Supérieur et de la Recherche (MESR) Région Alsace Germany Federal Ministry of Education and Research (BMBF) India Department of Biotechnology (DBT), Ministry of Science and Technology Italy Ministry of Education, University and Research (CNR) Japan Ministry for Economy, Trade and Industry (METI) Ministry of Education, Culture, Sports, Science and Technology (MEXT) Republic of Korea Ministry of Education, Science and Technology (MEST) New Zealand Health Research Council (HRC) Norway Research Council of Norway (RCN) Switzerland State Secretariat for Education and Research (SER) United Kingdom The International Human Frontier Science Biotechnology and Biological Sciences Research Program Organization (HFSPO) Council (BBSRC) 12 quai Saint Jean - BP 10034 Medical Research Council (MRC) 67080 Strasbourg CEDEX - France Fax. +33 (0)3 88 32 88 97 United States of America e-mail: [email protected] National Institutes of Health (NIH) Web site: www.hfsp.org National Science Foundation (NSF) Japanese web site: http://jhfsp.jsf.or.jp HUMAN FRONTIER SCIENCE PROGRAM The Human Frontier Science Program is unique, supporting international collaboration to undertake innovative, risky, basic research at the frontiers of the life sciences. -
Staff Changes Emma Bennett Joined the Academy As Exhibits Regularly in the UK and Europe
Council Election Nobel Prize Congratulations to the following Fellows who Dr Sydney Brenner were elected to serve as new members of FRS HonFMedSci was awarded The Council with effect from 21 November 2002. Nobel Prize in Physiology or Medicine for 2002 for his research into genetic regulation of organ development and Professor Carol Black programmed cell death. Though now based in California, President, The Royal College of Physicians and Professor of Sydney Brenner’s discoveries whilst working in Cambridge, Rheumatology, Royal Free and University College Medical School UK, laid the foundation for this year’s prize which was awarded jointly to H Robert Horvitz and John E Sulston. Professor Nancy Rothwell MRC Research Professor, University of Manchester Professor Julia Goodfellow Chief Executive, the Biotechnology and Biological Sciences Research Council Professor Colin Bird Sir Douglas Black Formerly Dean of Medicine and Provost of Faculty Group of Medical and Veterinary Medicine, University of Edinburgh Sir Douglas Black: died September 13, 2002. It is with Medical School much sadness that we record the passing of a distinguished Honorary Fellow. The Black report was widely Professor Jonathan Cohen regarded as the most authoritative publication on the link Dean, Brighton & Sussex Medical School between poor health and social deprivation. That it became Professor Thomas Kirkwood so influential was at least in part due to the then Professor of Medicine, University of Newcastle Upon Tyne Government’s efforts to suppress its publication. Council is pleased to announce the appointment of Sir John Skehel, Sir Douglas was a widely respected and much loved FRS FMedSci, as Shadow Vice-President with responsibility for Professor of Medicine at Manchester and later President of non-clinical affairs. -
Highly Multiplexed Spatially Resolved Gene Expression Profiling of Mouse Organogenesis
bioRxiv preprint doi: https://doi.org/10.1101/2020.11.20.391896; this version posted November 21, 2020. The copyright holder for this preprint (which was not certified by peer review) is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under aCC-BY-NC 4.0 International license. Highly multiplexed spatially resolved gene expression profiling of mouse organogenesis T. Lohoff1,2,3*, S. Ghazanfar4*, A. Missarova4,5‡, N. Koulena6‡, N. Pierson6‡, J.A. Griffiths4^, E.S. Bardot7, C.-H.L. Eng6, R.C.V. Tyser8, R. Argelaguet5, C. Guibentif1,9,10, S. Srinivas8, J. Briscoe11, B.D. Simons1,12,13, A.-K. Hadjantonakis7, B. Göttgens1,9, W. Reik1,3,14,15†, J. Nichols1,2†, L. Cai6†, J.C. Marioni4,5,15†* 1 Wellcome-Medical Research Council Cambridge Stem Cell Institute, University of Cambridge, Cambridge, UK 2 Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, UK 3 Epigenetics Programme, Babraham Institute, Cambridge, UK 4 Cancer Research UK Cambridge Institute, University of Cambridge, Cambridge, UK 5 European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Genome Campus, Cambridge, UK 6 Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA, USA 7 Developmental Biology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY, USA 8 Department of Physiology Anatomy and Genetics, University of Oxford, Oxford, UK 9 Department of Haematology, University of