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Scientific Report 2019-2020

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CBM Scientific Report 2019-2020 CENTRO DE BIOLOGÍA MOLECULAR SEVERO OCHOA 2 3 CENTRO DE BIOLOGÍA MOLECULAR SEVERO OCHOA C/ Nicolás Cabrera, 1 Campus de la Universidad Autónoma de Madrid 28049 Madrid Tel.: (+34) 91 196 4401 www.cbm.uam.es INDEX DIRECTOR´S REMARK 8 THE CBM IN A NUTSHELL 10-21 ERC PROJECTS 21 COVID-19 PROJECTS 22-29 GENOME DYNAMICS AND FUNCTION 30 GENOME DECODING 32 UGO BASTOLLA 34 COMPUTATIONAL BIOLOGY AND BIOINFORMATICS JOSÉ FERNÁNDEZ PIQUERAS / JAVIER SANTOS 36 GENETICS AND CELL BIOLOGY OF CANCER: T-CELL LYMPHOBLASTIC NEOPLASMS CRISANTO GUTIERREZ 38 CELL DIVISION, GENOME REPLICATION AND CHROMATIN ENCARNACIÓN MARTÍNEZ-SALAS 40 INTERNAL INITIATION OF TRANSLATION IN EUKARYOTIC mRNAs SANTIAGO RAMÓN 42 STRUCTURE AND FUNCTION OF MACROMOLECULAR COMPLEXES JOSÉ MARÍA REQUENA 44 REGULATION OF GENE EXPRESSION IN LEISHMANIA IVÁN VENTOSO / CÉSAR DE HARO/ JUAN JOSÉ BERLANGA / MIGUEL ÁNGEL RODRÍGUEZ 46 REGULATION OF mRNA TRANSLATION IN EUKARYOTES AND ITS IMPLICATIONS FOR ORGANISMAL LIFE GENOME MAINTENANCE AND INSTABILITY 48 LUIS BLANCO 50 GENOME MAINTENANCE AND VARIABILITY: ENZYMOLOGY OF DNA REPLICATION AND REPAIR MIGUEL DE VEGA 52 MAINTENANCE OF BACTERIAL GENOME STABILITY MARÍA GÓMEZ 54 FUNCTIONAL ORGANIZATION OF THE MAMMALIAN GENOME EMILIO LECONA 56 CHROMATIN, CANCER AND THE UBIQUITIN SYSTEM MARGARITA SALAS GROUP 58 REPLICATION OF BACTERIOPHAGE Ø29 DNA JOSÉ ANTONIO TERCERO 60 CHROMOSOME REPLICATION AND GENOME STABILITY 2 3 TISSUE AND ORGAN HOMEOSTASIS 62 CELL ARCHITECTURE & ORGANOGENESIS 64 MIGUEL ÁNGEL ALONSO 66 CELL POLARITY PAOLA BOVOLENTA 68 MORPHOGENESIS AND DIFFERENTIATION OF THE VERTEBRATE CNS ISABEL CORREAS 70 CYTOSKELETON-PLASMA MEMBRANE INTERACTIONS JOSÉ F. DE CELIS 72 CELL SIGNALING DURING IMAGINAL DEVELOPMENT IN DROSOPHILA CARLOS ESTELLA 74 GENE EXPRESSION CONTROL, PATTERNING AND GROWTH DURING APPENDAGE DEVELOPMENT FERNANDO MARTÍN BELMONTE 76 INTESTINAL MORPHOGENESIS AND HOMEOSTASIS NURIA MARTÍNEZ MARTÍN 78 INTEGRATED METABOLISM IN IMMUNITY DAVIZ MÍGUEZ 80 BIOPHYSICS AND SYSTEMS BIOLOGY JAIME MILLÁN 82 CELL BIOLOGY OF INFLAMMATION MAR RUIZ GÓMEZ / JOAQUIM CULÍ 84 GENETIC AND FUNCTIONAL ANALYSIS OF THE RENAL FILTRATION DIAPHRAGM IN HEALTH AND DISEASE ESTHER SERRANO SAIZ 86 TRANSCRIPTIONAL CONTROL OF SEXUAL DIFFERENTIATION OF THE NERVOUS SYSTEM CELL-CELL COMMUNICATION & INFLAMMATION 88 CARLOS CABAÑAS 90 FUNCTIONAL INTERACTIONS BETWEEN TETRASPANINS AND CELL ADHESION MOLECULES ISABEL GUERRERO 92 MECHANISMS OF CELL-CELL SIGNALING DURING DEVELOPMENT JOSÉ MARÍA IZQUIERDO 94 MOLECULAR AND CELLULAR BASIS OF THE PHYSIOPATHOLOGY ASSOCIATED WITH THE EXPRESSION OF INTRACELLULAR ANTIGENS MANUEL LÓPEZ CABRERA 96 MOLECULAR PATHOPHYSIOLOGY OF PERITONEAL INFLAMMATION AND FIBROSIS (PERINFIB) MARÍA MITTELBRUNN 98 IMMUNOMETABOLISM AND INFLAMMATION LAB FERNANDO RODRÍGUEZ PASCUAL 100 EXTRACELLULAR MATRIX REMODELING IN THE CARDIOVASCULAR SYSTEM MARÍA YÁÑEZ-MO 102 TETRASPANIN-ENRICHED MEMBRANE MICRODOMAINS IN EXTRACELLULAR VESICLES AND CELL ADHESION AND MIGRATION 2 3 SPECIFICATION, REPROGRAMMING & REGENERATION 104 ANTONIO BAONZA / FERNANDO J. DÍAZ-BENJUMEA 106 MECHANISMS OF STRESS RESPONSE IN THE DROSOPHILA NERVOUS SYSTEM ALBERTO MARTÍNEZ SERRANO 108 BIOLOGY OF HUMAN NEURAL STEM CELLS. POTENTIAL FOR CELL AND GENE THERAPY IN NEURODEGENERATION GINÉS MORATA / NATALIA AZPIAZU 110 TUMOROGENESIS AND REGENERATION IN DROSOPHILA ERNESTO SÁNCHEZ-HERRERO 112 SEGMENTAL SPECIFICATION AND PATTERN FORMATION IN DROSOPHILA PHYSIOLOGICAL AND PATHOLOGICAL PROCESSES 114 MOLECULAR NEUROPATHOLOGY 116 JESÚS ÁVILA / FÉLIX HERNÁNDEZ 118 TAU FUNCTION AND DYSFUNCTIONS IN ALZHEIMER DISEASE MARÍA JESÚS BULLIDO 120 PATHOGENIC MECHANISMS OF ALZHEIMER’S DISEASE JAVIER DÍAZ-NIDO 122 PHYSIOPATHOLOGY AND THERAPY OF NEURODEGENERATIVE DISEASES: FRIEDREICH’S ATAXIA FCO. JAVIER DÍEZ GUERRA 124 MOLECULAR BASES OF NEURONAL PLASTICITY CARLOS DOTTI 126 LABORATORY OF SURVIVAL AND PLASTICITY IN THE AGING BRAIN JOSÉ ANTONIO ESTEBAN 128 MECHANISMS OF SYNAPTIC PLASTICITY, AND CONTRIBUTION TO COGNITIVE FUNCTION ALFREDO GIMÉNEZ-CASSINA 130 INTEGRATION OF CELL SIGNALING AND ENERGY METABOLISM IN THE BRAIN MARÍA DOLORES LEDESMA 132 LIPIDS IN NEURONAL PHYSIOLOGY AND PATHOLOGY MARÍA LLORENS-MARTÍN 134 ADULT NEUROGENESIS AND NEURODEGENERATIVE DISEASES BEATRIZ LÓPEZ-CORCUERA 136 FISIOPATHOLOGY OF GLYCINE TRANSPORTERS IN GLYCINERGIC NEUROTRANSMISSION: HYPEREKPLEXIA AND PAIN JOSÉ J. LUCAS 138 MOLECULAR BASIS OF HUNTINGTON’S DISEASE AND OTHER CENTRAL NERVOUS SYSTEM DISORDERS CLAUDIO TOMA 140 THE GENETICS OF PSYCHIATRIC DISEASES 4 5 FRANCISCO WANDOSELL / BEATRIZ CUBELOS 142 MOLECULAR MECHANISMS OF NEURODEGENERATION FRANCISCOP ZAFRA / EVA PORLAN 144 MOLECULAR BASIS OF NEUROPROTECTION AND NEUROREPAIR METABOLIC AND SIGNALING NETWORKS IN DISEASE 146 EDUARDO BALSA 148 MOLECULAR AND METABOLIC MECHANISM UNDERLYING MITOCHONDRIAL DYSFUNCTION PEDRO BONAY 150 FUNCTIONAL GLYCOGENOMICS SUSANA CADENAS 152 MITOCHONDRIAL PATHOPHYSIOLOGY SARA COGLIATI 154 MOLECULAR MECHANISMS OF SEX-DIFFERENCES IN METABOLISM PHYSIOLOGY AND DISEASE JOSÉ MANUEL CUEZVA 156 THE ROLE OF MITOCHONDRIA IN HUMAN PATHOLOGY LAURA FORMENTINI 158 ROLE OF MITOCHONDRIAL METABOLISM ON THE PATHOPHYSIOLOGY OF SKELETAL MUSCLE SANTIAGO LAMAS 160 MOLECULAR PATHOPHYSIOLOGY OF FIBROSIS FEDERICO MAYOR JR 162 PATHO-PHYSIOLOGICAL IMPLICATIONS OF G PROTEIN-COUPLED RECEPTORS SIGNALING NETWORKS CRISTINA MURGA 164 SIGNALING PATHWAYS IN MOUSE MODELS OF METABOLIC AND CARDIOVASCULAR PATHOLOGIES PETRONILA PENELA 166 CELLULAR SIGNALING NETWORKS IN CANCER (ONCO-RESECEL) BELÉN PÉREZ / PILAR RODRÍGUEZ-POMBO 168 TRANSLATIONAL MEDICINE IN INBORN ERRORS OF METABOLISM AND OTHER RARE GENETIC DISEASES CATALINA RIBAS 170 REGULATORY FUNCTIONS AND MECHANISMS OF CELL SIGNALING PATHWAYS THROUGH G PROTEINS: A NEW INTERACTOME LOURDES RUIZ DESVIAT / EVA Mª RICHARD 172 PHYSIOPATHOLOGY STUDIES AND THERAPEUTICAL APPROACHES IN ANIMAL AND CELLULAR MODELS OF NEUROMETABOLIC DISEASES BEATRIZ PARDO / ARACELI DEL ARCO / JORGINA SATRÚSTEGUI / CAYETANO VON KOBBE 174 CALCIUM SIGNALING IN MITOCHONDRIA AND INSULIN/LEPTIN SIGNALING DURING AGEING JAVIER TRABA 176 MITOCHONDRIAL BIOLOGY IN IMMUNE MODULATION 4 5 INTERACTIONS WITH THE ENVIRONMENT 178 IMMUNE SYSTEM DEVELOPMENT AND FUNCTION 180 BALBINO ALARCÓN 182 SIGNAL TRANSDUCTION BY THE T-CELL ANTIGEN RECEPTOR ANTONIO ALCAMÍ 184 IMMUNITY AND VIROMICS CÉSAR COBALEDA 186 CELLULAR PLASTICITY IN DEVELOPMENT AND CANCER MARGARITA DEL VAL 188 VIRAL IMMUNOLOGY MANUEL FRESNO 190 IMMUNE DEVELOPMENT AND INFLAMMATORY-MEDIATED DISEASES NÚRIA GIRONÉS 192 IMMUNOREGULATORY MECHANISMS IN THE DEVELOPMENT OF CHAGAS DISEASE: TRANSLATIONAL APPLICATIONS JUAN MANUEL SERRADOR / MIGUEL ÁNGEL ÍÑIGUEZ 194 NITRIC OXIDE AND BIOACTIVE LIPIDS IN THE IMMUNE RESPONSE MARÍA N. NAVARRO 196 INTRACELLULAR SIGNALLING IN INFLAMMATORY PROCESSES MARÍA LUISA TORIBIO 198 DEVELOPMENT OF THE HUMAN LYMPHOHEMATOPOIETIC SYSTEM HISSE MARTIEN VAN SANTEN 200 TCR DOMAINS IN T CELL DIFFERENTIATION AND (PATHO)PHYSIOLOGICAL AND THERAPEUTIC RESPONSES MICROBES IN HEALTH AND WELFARE 202 JOSÉ M. ALMENDRAL 204 ssDNA VIRUS EVOLUTION, PATHOGENESIS, AND ANTI-CANCER POTENTIAL RICARDO AMILS 206 MOLECULAR ECOLOGY OF EXTREME ENVIRONMENTS JOSÉ BERENGUER 208 BIOTECHNOLOGY ANF GENETICS OF EXTREME THERMOPHILES ESTEBAN DOMINGO / CELIA PERALES 210 GENETIC VARIABILITY OF RNA VIRUSES MARÍA FERNÁNDEZ LOBATO 212 YEAST ENZYME BIOENGINEERING TO GENERATE BIOACTIVE COMPOUNDS MAURICIO G. MATEU 214 VIRUS ENGINEERING AND NANOBIOTECHNOLOGY PAULINO GÓMEZ-PUERTAS 216 MOLECULAR MODELLING AURELIO HIDALGO 218 ULTRAHIGH-THROUGHPUT DISCOVERY AND ENGINEERING OF ENZYMES FOR BIOTECHNOLOGICAL APPLICATIONS (HT DISCOVERY LAB) 6 7 WILFRIED J.J. MEIJER 220 PLASMID CONJUGATION IN GRAM-POSITIVE BACTERIA LUIS MENÉNDEZ ARIAS 222 HUMAN IMMUNODEFICIENCY VIRUS REPLICATION AND ANTIRETROVIRAL THERAPY MARÍA GRACIELA PUCCIARELLI 224 RNA-BASED CONTROL OF LISTERIA ADAPTATION TO STRESS AND VIRULENCE YOLANDA REVILLA 226 VIRUS-CELL INTERACTION AND VACCINES DEVELOPMENT: THE ASFV MODEL MARGARITA SÁIZ 228 MODULATION OF INNATE IMMUNE RESPONSES BY VIRAL PROTEASES AND RNAS DERIVED FROM VIRAL GENOMES. BIOTHERAPEUTIC APPLICATION FRANCISCO SOBRINO 230 NEW STRATEGIES FOR PREVENTION AND CONTROL OF VIRAL DISEASES: FOOT-AND-MOUTH DISEASE VIRUS AS A MODEL SCIENCE AND SOCIETY DEPARTMENT 232 José Antonio López Guerrero 234 SCIENTIFIC FACILITIES 236 ANIMAL FACILITY (Elena Hevia) 238 BIOINFORMATICS FACILITY (David Abia) 239 FLOW CITOMETRY FACILITY (Berta Raposo) 240 FERMENTATION FACILITY (Dionisio Ureña) 241 GENOMICS AND NEXT GENERATION SEQUENCING FACILITY (Fernando Carrasco) 242 ELECTRON MICROSCOPY FACILITY (EMF) (María Teresa Rejas) 243 OPTICAL AND CONFOCAL MICROSCOPY CORE FACILITY (SMOC) (María Ángeles Muñoz) 244 PROTEOMICS AND PROTEIN CHEMISTRY CORE FACILITY (Anabel Marina) 245 DROSOPHILA TRANSGENESIS FACILITY (Eva Caminero / Mar Casado) 246 CBM-CNB TRANSGENESIS FACILITY (María Belén Pintado) 247 GENERAL SERVICES 248 SEMINARS AND LECTURES 252-263 6 7 Lourdes Ruiz Desviat CBM DIRECTOR Dear colleagues and friends, I am pleased to present the scientific report 2019-20 of the Centro de Biología Molecular Severo Ochoa (CBM), giving an overview of the events and scientific and strategic activities during this period. Looking back at 2019-2020, the overwhelming situation of COVID-19 pandemic, in which we are still immersed, immediately comes to everybody’s mind. However, I would like to highlight 2019-2020 as the years in which our center completed a substantial remodelling process, following the advice of the SAB that visited us in December 2018 and the internal analysis
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    Doctora honoris causa Margarita Salas Falgueras Doctora honoris causa MARGARITA SALAS FALGUERAS Discurs llegit a la cerimònia d’investidura celebrada a la sala d’actes de l’edifici Rectorat el dia 18 d’abril de l’any 2018 Índex Presentació de Margarita Salas Falgueras per Montserrat Llagostera 5 Discurs de Margarita Salas Falgueras 23 Currículum vitae de Margarita Salas Falgueras 39 Acord de Consell de Govern 45 PRESENTACIÓ DE MARGARITA SALAS FALGUERAS PER MONTSERRAT LLAGOSTERA Rectora Magnífica, Señores Vicerrectores, Señores Decanos, Apreciados colegas, Estimados estudiantes, Señoras y Señores, El pasado 3 de septiembre se cumplieron cien años de la publicación del artículo de Félix D’Hérelle titulado «Sur un microbe invisible an- tagoniste des bacilles dysenteriques» en el número 165 de la revista Comptes Rendus de la Académie des Sciences En él se utilizó por primera vez en la historia de la ciencia el término bacteriófago, que significa «comedor de bacterias» Desde entonces se ha utilizado la palabra bacteriófago para denominar a los virus que infectan bacte- rias Y también el pasado septiembre se cumplieron cincuenta años de dedicación intensa de la Dra Margarita Salas Falgueras al estudio y comprensión de la biología molecular del bacteriófago f29, un virus bacteriano que consta tan solo de veinte genes pero que esconde una maquinaria molecular muy compleja Teniendo presentes ambos hitos como telón de fondo, es para mí un honor pronunciar esta laudatio en nombre del profesorado de las facultades de Ciencias y Biociencias para exponerles
  • Diversity and Evolution of Novel Invertebrate DNA Viruses Revealed by Meta-Transcriptomics

    Diversity and Evolution of Novel Invertebrate DNA Viruses Revealed by Meta-Transcriptomics

    viruses Article Diversity and Evolution of Novel Invertebrate DNA Viruses Revealed by Meta-Transcriptomics Ashleigh F. Porter 1, Mang Shi 1, John-Sebastian Eden 1,2 , Yong-Zhen Zhang 3,4 and Edward C. Holmes 1,3,* 1 Marie Bashir Institute for Infectious Diseases and Biosecurity, Charles Perkins Centre, School of Life & Environmental Sciences and Sydney Medical School, The University of Sydney, Sydney, NSW 2006, Australia; [email protected] (A.F.P.); [email protected] (M.S.); [email protected] (J.-S.E.) 2 Centre for Virus Research, Westmead Institute for Medical Research, Westmead, NSW 2145, Australia 3 Shanghai Public Health Clinical Center and School of Public Health, Fudan University, Shanghai 201500, China; [email protected] 4 Department of Zoonosis, National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Changping, Beijing 102206, China * Correspondence: [email protected]; Tel.: +61-2-9351-5591 Received: 17 October 2019; Accepted: 23 November 2019; Published: 25 November 2019 Abstract: DNA viruses comprise a wide array of genome structures and infect diverse host species. To date, most studies of DNA viruses have focused on those with the strongest disease associations. Accordingly, there has been a marked lack of sampling of DNA viruses from invertebrates. Bulk RNA sequencing has resulted in the discovery of a myriad of novel RNA viruses, and herein we used this methodology to identify actively transcribing DNA viruses in meta-transcriptomic libraries of diverse invertebrate species. Our analysis revealed high levels of phylogenetic diversity in DNA viruses, including 13 species from the Parvoviridae, Circoviridae, and Genomoviridae families of single-stranded DNA virus families, and six double-stranded DNA virus species from the Nudiviridae, Polyomaviridae, and Herpesviridae, for which few invertebrate viruses have been identified to date.
  • Epigenetics, Obesity and Metabolism

    Epigenetics, Obesity and Metabolism

    Epigenetics, Obesity and Metabolism Wellcome Genome Campus Conference Centre Hinxton, Cambridge, UK October 11-14, 2015 Conference Program Sunday, October 11 14:00 – 15:00 Registration 15:00 Welcome and introductions Nessa Carey & Wolf Reik Session 1: Introduction into the three fields Chair: Wolf Reik 15:00 – 15:45 Adrian Bird (University of Edinburgh, UK) DNA methylation and the brain 15:45 – 16:30 Stephen O'Rahilly (University of Cambridge, UK) Metabolic Disease: lessons from human genetics 16:30 – 17:15 Jens Bruning (Max Planck Institute, Germany) Neonatal insulin action impairs hypothalamic neurocircuit formation in response to maternal high-fat feeding 17:15 – 17:30 Abcam 17:30 – 19:30 Poster Session and welcome reception Dinner Monday, October 12 07:30 – 09:00 Breakfast Session 2: How circadian rhythms link with, and are linked by, the three topics Chair: Stephen O’Rahily and Jens Bruning 09:30 – 10:05 Wolfgang Wagner (Helmholtz Institute for Biomedical Engineering, Germany) DNA Methylation changes in replicative senescence and aging 10:05 – 10:40 Sung Hee Baek (Seoul National University, South Korea) Phosphorylation of LSD1 by PKCalpha is crucial for circadian rhythmicity and phase resetting 10:40 – 10:55 Guillaume Rey (University of Cambridge, UK) Central carbon metabolism regulates circadian oscillations Break 11:30 – 12:05 Andrew Loudon (University of Manchester, UK) The generation of the seasonal rhythm: role of circadian clock genes and epigenetics in the circannual clockwork 12:05 – 12:40 Ueli Schibler (University of Geneva,
  • Ruta Marzo 2010 Segovia Ordenada Por Dias (Oficial)

    Ruta Marzo 2010 Segovia Ordenada Por Dias (Oficial)

    RUTA MARZO 2010 SEGOVIA ORDENADA POR DIAS (OFICIAL) centro localidad Provincia Equipos Tiempo Fecha de Visita CEO VIRGEN DE LA PEÑA SEPULVEDA SEGOVIA 61 150 12/04/2010 CP CARDENAL CISNEROS BOCEGUILLAS SEGOVIA 23 150 12/04/2010 CRA DE AYLLON AYLLON SEGOVIA 22 150 12/04/2010 CRA DE AYLLON CAMPO DE SAN PEDRO SEGOVIA 3 30 12/04/2010 CRA DE RIAZA CEREZO DE ABAJO SEGOVIA 1 30 12/04/2010 CRA DE RIAZA RIAZA SEGOVIA 36 150 12/04/2010 CRA DE RIAZA VILLAREJO SEGOVIA 1 30 12/04/2010 CRA LA SIERRA MATABUENA SEGOVIA 4 30 12/04/2010 CRA LA SIERRA NAVAFRIA SEGOVIA 6 60 12/04/2010 CRA LA SIERRA PEDRAZA SEGOVIA 2 30 12/04/2010 CRA LA SIERRA PRADENA SEGOVIA 30 150 12/04/2010 CRA CAMPOS CASTELLANOSCANTIMPALOS SEGOVIA 20 90 13/04/2010 CRA CAMPOS CASTELLANOSESCARABAJOSA DE CABEZASSEGOVIA 1 30 13/04/2010 CRA CAMPOS CASTELLANOSMOZONCILLO SEGOVIA 8 60 13/04/2010 CRA CAMPOS DE CASTILLA ALDEANUEVA DEL CODONALSEGOVIA 1 30 13/04/2010 CRA CAMPOS DE CASTILLA CODORNIZ SEGOVIA 1 30 13/04/2010 CRA CAMPOS DE CASTILLA JUARROS DE VOLTOYA SEGOVIA 1 30 13/04/2010 CRA CAMPOS DE CASTILLA MARTIN MUÑOZ DE LAS POSADASSEGOVIA 17 90 13/04/2010 CP LA CHOPERA SACRAMENIA SEGOVIA 16 90 13/04/2010 CP LOS ARENALES CANTALEJO SEGOVIA 69 150 13/04/2010 CP MIGUEL DE CERVANTES NAVALMANZANO SEGOVIA 13 90 13/04/2010 CP SAN JUAN BAUTISTA CARBONERO EL MAYOR SEGOVIA 25 150 13/04/2010 CRA EL CARRACILLO CAMPO DE CUELLAR SEGOVIA 2 30 14/04/2010 CRA EL CARRACILLO CHATUN SEGOVIA 3 30 14/04/2010 CRA EL CARRACILLO GOMEZSERRACIN SEGOVIA 1 30 14/04/2010 CRA EL CARRACILLO MUDRIAN SEGOVIA 1 30 14/04/2010 CRA