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Rmn 2019 20 2.Pdf Revista Mexicana de Neurociencia Publicación oficial de la Academia Mexicana de Neurología A.C. © Permanyer 2019 VOLUME 20 - NUMBER 2 / Marzo-Abril 2019 – ISSN: 1665-5044 . eISSN: 2604-6180 www.revmexneurociencia.com of the publisher Editorial Clinical guidelines from the Priority Epilepsy Program of the public health sector in Mexico 56 J.C. Reséndiz-Aparicio Artículos de revisión Clinical guideline: definition and classification of epilepsy 63 J.C. Reséndiz-Aparicio, J.C. Pérez-García, E. Olivas-Peña, E. García-Cuevas, Y.L. Roque-Villavicencio, M. Hernández-Hernández, J.I. Castro-Macías and J.D. Rayo-Mares Clinical guideline: management of seizures in the emergency room 69 J. Visoso-Franco, L. Romero-Ocampo, J.A. Santos-Zambrano, A. Serrano-González and E. Castro-Martínez Clinical guideline: management of the first unprovoked epileptic seizure in adults and children 76 J.A. Gien-López, R.A. Cuevas-Escalante, E. García-Cuevas, M.R. Márquez-Estudillo, B.E. Villaseñor-Anguiano, R. Leal-Cantú and R.E. Jiménez-Arredondo Clinical guideline: antiepileptic drugs of choice for focal and generalized seizures in adult patients with epilepsy 82 L. Rivera-Castaño, H. Sentíes-Madrid, J. Berumen-Jaik and I.E. Martínez-Juárez Clinical guideline: antiepileptic drugs of choice for epileptic syndromes and epilepsies in pediatric patients 89 J.C. Reséndiz-Aparicio, J.M. Padilla-Huicab, I.E. Martínez-Juárez, G. Hernández-Martínez, E. López-Correa, B. Vázquez-Juárez, R. Huerta-Albarrán and C. Rivera-Acuña Clinical guideline: febrile seizures, diagnosis and treatment 97 C. Aguirre-Velázquez, A.M. Huerta Hurtado, H. Ceja-Moreno, K. Salgado-Hernández, R. San Román-Tovar, M.A. Ortiz-Villalpando, Avril Molina-García, G. Vargas-Ramírez, J. López-Rivera and R. Huerta-Albarrán Clinical guideline: epilepsy in pregnancy and women of childbearing age 104 P.O. González-Vargas, Y. Matuk-Pérez, J.L. Sosa Hernández, G. Quiñones-Canales, S.E. Silva-Sánchez, G. Aguayo-Leytte, S. Medina-Benitez, J.M. Ibarra-Puig, L.G. María del Consuelo and Elvira Castro-Martínez Clinical guideline: status epilepticus in children and adults 110 A. Olmos-López, J. Ibarra-Aguilar, J.O. Cornelio-Nieto, L.A. Ocaña-Hernández, M.A. Márquez-Amaya, N. Luna-López, J.C. Reséndiz-Aparicio and I. Rodríguez-Leyva Clinical guideline: pre-operative evaluation of epilepsy surgery 116 M. Ruiz-García, M.A. Alonso-Vanegas, S.P. Pérez-Reyes, G. Quiñones-Canales, I. Rodríguez-Leyva, H.R. Martínez-Rodríguez and E. Barragán-Pérez Clinical guide: discontinuing chronic antiepileptic drug treatment 123 M.C. Loy-Gerala, O.M. Ibarra-Bravo, M.R. Márquez-Estudillo, F. Mena-Barranco, F.J. Rogel-Ortiz, S.E. Silva-Sánchez, H. Villegas-Peña and A. Molina-García No part of this publication may be reproduced or photocopying without the prior written permission PERMANYER www.permanyer.com Revista Mexicana de Neurociencia EDITORIAL Clinical guidelines from the Priority Epilepsy Program of the public health sector in Mexico © Permanyer 2019 J.C. Reséndiz-Aparicio Hospital Psiquiátrico Infantil Dr. Juan N. Navarro y P.P.E, Instituto Nacional de Neurología y Neurocirugía Dr. Manuel Velasco Suárez. Mexico City, . Mexico of the publisher The Programa Prioritario de Epilepsia (PPE - Priority planned for this task. The national coordination is led Epilepsy Program) was created based on the accord by its creator and founder Francisco Rubio Donnadieu, published in the Mexican Official Gazette of the Fede- MD and by the author. ration on October 24th, 1984. This program has labored The development of the first Clinical Guidelines in an uninterrupted manner to regulate, coordinate, (CGs) has been a laborious effort, one that has been methodize, and optimize the strategies in favor of pa- finished due to the work of all the coordinators of the tients with epilepsy, as well as their families and socie- PPE, who are neurologists and pediatric neurologists ty. There are currently 78 centers of integral treatment certified by the Mexican Board of Neurology and who for epilepsy in Mexico, located in various hospitals be- work in one of the many institutions of the health sec- longing to Mexico’s health sector. tor in Mexico. To elaborate the CG, all the coordinators The headquarters for the national coordination is in of the PPE met in person in two meetings, the first in the Instituto Nacional de Neurología y Neurocirugía the city of Leon and the second in the city of Puebla, (National Institute of Neurology and Neurosurgery) where we formed workgroups for each CG. These “Dr. Manuel Velasco Suarez” (INNN due to its acronym meetings were possible due to the support of the fe- in Spanish) in Mexico City, from where all actions are deral government and the contributions of the Correspondence: Date of reception: 01-02-2019 Available online: 12-04-2019 No part of this publication may be reproduced or photocopying without the prior written permission Juan Carlos Reséndiz-Aparicio Date of acceptance: 28-02-2019 Rev Mex Neuroci. 2019;20(2):56-62 E-mail: [email protected] DOI: 10.24875/RMN.M19000041 www.revmexneurociencia.com 1665-5044/© 2019. Academia Mexicana de Neurología A.C. Published by Permanyer México. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). 56 J. C. Reséndiz-Aparicio: Clinical Guidelines of the Priority Epilepsy Program pharmaceutical laboratories that aid in training primary throughout the various institutions of the health sector; health-care physicians. These CGs are designed to however, it is understood that the application of said aid the primary health-care physicians and the spe- recommendations depends on many factors. It is im- cialists in making adequate decisions when approa- portant to state that there are no conflicts of interest in ching epileptic patients of different age groups and these CGs due to the fact that they are editorially inde- genders. These are the culmination of the experience pendent of any external funding. of their authors, who have followed the necessary Finally, I would like to thank the INNN for their hos- steps for proper and updated scientific research, using pitality and support in the coordination of the Program, the criterion of the American Epilepsy Society 2016 to the Mexican Academy of Neurology for the publication © Permanyer 2019 analyze the levels of evidence and recommendations in their magazine, the Mexican Society of Pediatric . including the benefit for the patients. To evaluate the Neurology who supported the process of translating the quality of the CG, two experts coordinated each table CG to English, and the authorities of the Hospital Psi- and applied the Spanish version of the AGREE instru- quiátrico Infantil (Children’s Psychiatric Hospital) of ment of 2001. Mexico City who have allowed me to work as the ad- Due to the advances in the knowledge of epilepsy, junct executive member of the Priority Epilepsy Pro- the PPE group aims to update the CG every 5 years. gram and above all, thank you to the coordinators of of the publisher These CGs constitute a series of recommendations the Priority Epilepsy Program who worked on this pro- developed by a group of medical physicians that have ject; this work is dedicated to them and their families a particular interest in the field of epilepsy and work and to which I express my most ample recognition. Juan Carlos Reséndiz Aparicio, MD, Adjunct Executive Member American Epilepsy Society 2016 Article Classification: Evidence Class I: A randomized, prospective and controlled clinical trial with masked outcome assessment, in a repre- sentative population. The following are required: a. No more than two specified primary results. b. Blind allocation of subjects. c. Exclusion/inclusion criteria are clearly defined. d. Relevant baseline characteristics are presented and substantially equivalent among treatment groups or there is appropriate statistical adjustment for differences. e. Adequate accounting for dropouts with numbers sufficiently low to have a minimal potential for bias. (study was completed with at least 80% of the enrolled subjects). f. Demonstration of superior design of the studies or demonstration of non-inferiority with a 10% non- inferior design margin. Class II: A randomized, prospective and controlled clinical trial with masked outcome assessment that lacks one or two criteria of Class I a-e above, or a prospective matched cohort study with masked objec- tive outcome assessment in a representative population that meets a-e. Class III: All other control trials in a representative population, where outcome was independently assessed by objective outcome measurement. Class IV: Evidence from non-controlled trials, including series reports, case reports, consensus, or expert opinion. No part of this publication may be reproduced or photocopying without the prior written permission 57 Rev Mex Neuroci. 2019;20 Evidence for the Conclusion and Recommendation Recommendation Conclusion, Level A Level A Established as effective, ineffective, or harmful for the given condition in One or more Class I trials or the specified population. two or more Class II trials. Recommendation: Level B Must be done or must not be done. One or more Class II trials or Conclusion, Level B three or more class III trials. Probably effective, ineffective, or harmful for the given condition in the © Permanyer 2019 Level C specified population. Two or more Class III trials. Recommendation: . Level U It must be considered or must not be considered. Absence of trails that com- Conclusion, Level C plement levels A, B, or C. Possibly effective, ineffective, or harmful for the given condition in the Level R-PPE specified population. Recommendation: of the publisher It could be considered or should not be considered. Conclusion, Level U Data is insufficient or inadequate given current knowledge, treatment is unproven Recommendation: Should not be performed Conclusion, Level R-PPE No evidence from levels A, B, or C, but it is a recommendation by con- sensus of the group that elaborated the Clinical Guidelines of the PPE.
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