Survival Analysis of Patients with Breast Cancer
ANTICANCER RESEARCH 37 : 5813-5820 (2017) doi:10.21873/anticanres.12024 Survival Analysis of Patients with Breast Cancer Undergoing a Modified Radical Mastectomy With or Without a Thoracic Paravertebral Block: a 5-Year Follow-up of a Randomized Controlled Trial MANOJ KUMAR KARMAKAR 1, WINNIE SAMY 1, ANNA LEE 1, JIA WEI LI 1, WING CHEONG CHAN 2, PHOON PING CHEN 3 and BAN C.H. TSUI 4 1Department of Anesthesia and Intensive Care, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong, P.R. China; 2Department of Surgery, North District Hospital, Sheung Shui, New Territories, Hong Kong, P.R. China; 3Departments of Anesthesiology and Operating Services, North District Hospital, Sheung Shui, New Territories, Hong Kong, P.R. China; 4Department of Anesthesiology, Perioperative and Pain Medicine, Stanford University School of Medicine, Stanford, CA, U.S.A. Abstract. Aim: This 5-year prospective follow-up of women nor from that with GA plus c-TPVB (HR=0.79, 95% CI=0.21- randomized to general anesthesia (GA) with or without a 2.96) (p=0.88). Compared to the GA-only group, the risk of thoracic paravertebral block (TPVB) examined the risk of mortality was similarly not different from that of the two other local recurrence, metastasis and mortality after breast cancer groups (HR=2.57, 95% CI=0.66-9.92; and HR=0.66, 95% surgery. Patients and Methods: A total of 180 patients CI=0.11-3.97, respectively, p=0.15). Conclusion: Although undergoing modified radical mastectomy were randomized to the original study was underpowered to properly address one of three study groups: standardized GA only; GA with a long-term outcomes, the results of this analysis suggest that single-injection TPVB (s-TPVB) and placebo paravertebral TPVB, administered whether as a single-injection or infusion after surgery for 72-h; and GA plus with continuous continuous infusion during the perioperative period, had little TPVB (c-TPVB) for 72-h postoperatively.
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