JOURNAL OF MEDICAL INTERNET RESEARCH Gold et al Original Paper Effectiveness of Digital Interventions for Reducing Behavioral Risks of Cardiovascular Disease in Nonclinical Adult Populations: Systematic Review of Reviews Natalie Gold1,2, DPhil; Amy Yau1,3, PhD; Benjamin Rigby1,4, MA; Chris Dyke1,5, MSc; Elizabeth Alice Remfry1,6, BSc; Tim Chadborn1, PhD 1Public Health England, London, United Kingdom 2Centre for Philosophy of Natural and Social Science, London School of Economics and Political Science, London, United Kingdom 3Centre for Diet and Activity Research, MRC Epidemiology Unit, University of Cambridge, Cambridge, United Kingdom 4Department of Sociology, University of Durham, Durham, United Kingdom 5Department of Social Science, Institute of Education, University College London, London, United Kingdom 6Global Health Section, Department of Public Health, University of Copenhagen, Copenhagen, Denmark Corresponding Author: Natalie Gold, DPhil Public Health England Wellington House 133-155 Waterloo Road London, SE1 8UG United Kingdom Phone: 44 9767839044 Email:
[email protected] Abstract Background: Digital health interventions are increasingly being used as a supplement or replacement for face-to-face services as a part of predictive prevention. They may be offered to those who are at high risk of cardiovascular disease and need to improve their diet, increase physical activity, stop smoking, or reduce alcohol consumption. Despite the popularity of these interventions, there is no overall summary and comparison of the effectiveness of different modes of delivery of a digital intervention to inform policy. Objective: This review aims to summarize the effectiveness of digital interventions in improving behavioral and health outcomes related to physical activity, smoking, alcohol consumption, or diet in nonclinical adult populations and to identify the effectiveness of different modes of delivery of digital interventions.