Anti-SEMA3C Polyclonal Antibody (DPABH-15816) This Product Is for Research Use Only and Is Not Intended for Diagnostic Use

Anti-SEMA3C polyclonal antibody (DPABH-15816) This product is for research use only and is not intended for diagnostic use.

PRODUCT INFORMATION

Antigen Description The Semaphorins constitute a large family of secreted and membrane-tethered cell signaling molecules. They have functions in neural development, immunology, cardiac growth, vascular development, lung morphogenesis and axial bone patterning. Semaphorins are defined by the presence of a conserved Sema domain at the N-terminus. These proteins can be classified into eight classes depending on their structure and species origin. Classes 3 through 7 are found in vertebrates; class 3 are secreted, class 7 are GPI-anchored and class 4 through 6 are transmembrane proteins. Two distinct transmembrane receptor families have been identified as Semaphorin receptors. Neuropilins provide binding specificity for the class 3 Semaphorins, whereas Plexins, which also contain a Sema domain serve as signaling partners for class 3 Semaphorins and as functional receptors for transmembrane Semaphorins. Semaphorin 3c inhibits axonal extension by providing local signals to specify territories inaccessible for growing axons. It is expressed maximally between days E10-12 with moderate levels from day E13 until birth.

Immunogen Synthetic peptide conjugated to KLH derived from within residues 700 to the C-terminus of Human Semaphorin 3c.

Isotype IgG

Source/Host Rabbit

Species Reactivity Human

Purification Immunogen affinity purified

Conjugate Unconjugated

Format Liquid

Size 100 μg

Buffer Constituents: 1% BSA, PBS, pH 7.4

Preservative 0.02% Sodium Azide

Storage Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

45-1 Ramsey Road, Shirley, NY 11967, USA Email: [email protected]

Gene Name SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 4C [ Homo sapiens ]

Official Symbol SEMA3C

Synonyms SEMA3C; sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C; SemE; SEMAE; semaphorin-3C; sema E; semaphorin E; semaphorin-E;

Entrez Gene ID 10512

Protein Refseq NP_006370.1

UniProt ID B4E2I9

Pathway Axon guidance;

Function receptor activity; semaphorin receptor binding;

45-1 Ramsey Road, Shirley, NY 11967, USA Email: [email protected]