5 0 0 2 r e t n i W cancer DISCOVERY & CARE

UPMC Cancer Centers and University of Cancer Institute UPMC Cancer Centers elcome to the inaugural issue of Cancer Discovery & Care. Through this new publication, we are pleased and University of Pittsburgh Cancer Institute to share stories of the incredible work performed each and every day at UPMC Cancer Centers and the University of Pittsburgh Cancer Institute. They are stories of our researchers’ quest to unravel the causes CONTENTS of cancer and map its progression, while in the process laying the foundation for the improved treatments Ronald B. Herberman, MD Andrew S. Baum, PhD W of tomorrow. They are stories of clinicians who, with care and compassion, use the most advanced methods Director UPCI Deputy Director, for detection, prevention, and treatment. They are stories of health care experts who work tirelessly to educate the public about Stanley M. Marks, MD Cancer Control and Population Services Deputy Director, Clinical Services Preet M. Chaudhary, MD cancer prevention and treatment. In short, they are stories of hope. Jeffrey E. Shogan, MD UPCI Deputy Director, Clinical Investigations This is truly an exciting time, one when we’re learning more than ever before about cancer and developing better strategies for Deputy Director, Business Affairs Kenneth A. Foon, MD treatment, early detection, and cancer prevention. Our clinical care network, which extends throughout western , Charles E. Bogosta UPCI Deputy Director, Vice President, Cancer Services with the Hillman Cancer Center as the hub, makes UPMC Cancer Centers one of the largest cancer care providers in Translational Research the country. And thanks to the generous support from the University of Pittsburgh Medical Center and many organizations, Richard D. Wood, PhD UPCI Deputy Director, Basic Research businesses, and individuals, we continue to recruit world-renowned investigators to ensure the preeminent quality and [2-5] achievements of our research activities well into the future. As a result of these activities, UPCI ADVISORY COUNCIL our program for cancer research and care has grown to be one of the top ranked programs Sy Holzer Elsie H. Hillman A Wolf in Sheep’s Clothing in the nation. Chair Vice Chair Deceptive virus teaches how cancer Thomas Balestrieri David Malone develops — and how it may be stopped. Adding to the excitement is the work of the Pennsylvania Cancer Control Consortium, G. Nicholas Beckwith III Kevin McClatchy or PAC3, an extensive coalition comprising some of the state’s top health care leaders that James Broadhurst Martin G. McGuinn was tasked by the state’s Department of Health with reducing the human and economic William M. Cooper Katie McSorley burden of cancer for all Pennsylvania residents. Recently, we were intimately involved in Harriet Crawford Bob Meyer [6-7] Barbara Crown Thomas H. Nimick Jr. Beyond the X-ray PAC3’s development of the state’s first-ever comprehensive cancer control plan. This five-year Joseph W. DeNardo Eugene J. O’Sullivan plan provides a clear, unifying vision of cancer-related priorities that will mobilize Spiral CT opens new detection possibilities Robert C. Denove Arnold Palmer state-wide support, build effective partnerships, and enhance the infrastructure to fight cancer Douglas P. Dick Brian Patten for deadliest of cancers. on all levels, in every community throughout the state. Lee B. Foster The Honorable John E. Peterson Chip Ganassi The Honorable John R. Pippy The burden of cancer on Pennsylvanians is painfully evident. It is the second leading cause of Kent G. George Jane Roesch “... we quite literally will be Edwin H. Gott Jr. Cynthia Roth [8-9] death in the state, accounting for approximately 30,000 deaths each year. This statistic, due in Thomas B. Grealish Susan C. Santa-Cruz Breaking Down Barriers leading efforts to build a future large part to our aging population, places Pennsylvania among the nation’s top half of states Roy W. Haley Frederic B. Sargent for overall cancer mortality rates. Furthermore, it is estimated that by year’s end, there will be Robert W. Hannan Steve Schwarzwaelder Personal experience driving force behind without cancer for patients in I. N. Rendall Harper Jr. Daniel H. Shapira disparities initiative Pennsylvania and beyond.” more than 72,000 new cancer diagnoses in the state, the fifth highest total for any state The Honorable Melissa A. Hart Robert Slagle in the nation. Mark Hart Lorene Steffes Sakiko Ishii Arthur H. Stroyd Unfortunately, despite the significant past efforts to address this burden, Pennsylvania has had a fragmented approach to cancer Bill Isler Janet B. Taber (Honorary member) [10-11] and inadequate organizational infrastructures. The PAC3 plan’s unifying vision means best practices will be identified and William Kassling Thomas VanKirk Philanthropy Soars at promoted, collaborations will increase, and duplication of effort will decrease, all within a framework of long-term planning, Mario Lemieux Lawrence M. Wagner Sally Levin Jack Wagner Annual Cancer Gala implementation, and evaluation. The plan marshals existing strengths and resources for innovative, research-based strategies in Edward J. Lewis William Watts Hope Takes Flight event raises $4.2 million for eight areas: prevention and healthy lifestyles; screening and diagnostic follow-up; treatment and care delivery; quality of Jeffrey Lipton The Honorable John Weinstein cancer research and patient care. life; access; well-being; research; and cancer-related information management and dissemination. George A. Fechter In what is a powerful affirmation of our leadership in cancer research, prevention, diagnosis, and treatment, UPMC Cancer Centers EXTERNAL SCIENTIFIC ADVISORY COUNCIL [12-15] and the University of Pittsburgh Cancer Institute were selected to house the PAC3 Coordinating Office, which will be responsible Edward Benz Jr., MD Enrico Mihich, MD for implementing the plan’s objectives. These activities are well under way and will be further guided under my leadership as the President, Dana-Farber Cancer Institute Executive Director for Sponsored Programs State-of-the-Art Cancer Care Director, Dana-Farber/Harvard Cancer Center Distinguished Member, first chairman of the PAC3 board of directors. With the PAC3 Coordinating Office located here, we quite literally will be leading Janice Dutcher, MD Dept. of Pharmacology & Therapeutics Close to Home efforts to build a future without cancer for patients in Pennsylvania and beyond. Associate Director for Clinical Affairs, Professor, Molecular Pharmacology Cancer network brings world-class care SUNY/Buffalo Roswell Park Cancer Professor of Medicine to patients in their communities. The Comprehensive Cancer Center Joseph Pagano, MD Our Lady of Mercy Medical Center Lineberger Professor of Cancer Research Paul Engstrom, MD and Director Emeritus Senior Vice President, Population Sciences University of North Carolina at Chapel Hill [16-19] Fox Chase Cancer Center School of Medicine Ralph Reisfeld, PhD The Power of Partnership William B. Ershler, MD Acknowledging those who financially Ronald B. Herberman, MD Director, Geriatric Oncology Consortium Head, Laboratory of Tumor Cell Biology Scripps Clinic support cancer research and care Tomas Lindahl, MD, FRS George Stark, PhD Hillman Professor of Oncology Cancer Research UK London Research Institute Chairman, Lerner Research Institute Director, UPMC Cancer Centers and the University of Pittsburgh Cancer Institute Clare Hall Laboratories The Cleveland Clinic Foundation Candace S. Johnson, PhD [20] Senior Vice President for News Briefs Translational Research Professor, Pharmaceutical Sciences Roswell Park Cancer Institute Once upon a time, a Wolf resolved to disguise his appearance in order to secure food more easily. Encased in the skin of a sheep, he pastured with the flock, deceiving the shepherd

by his costume. In the evening, he was shut up by the shepherd in the fold; the gate was closed, and the

entrance made thoroughly secure. But the shepherd, returning to the fold during the night to obtain

meat for the next day, mistakenly caught up the Wolf instead of a sheep, and killed him instantly.

— Aesop

A Wolf in Sheep’s Clothing

Deceptive virus teaches how cancer develops — and how it may be stopped.

In the classic fable by Aesop, a wolf ends up the victim of his own They discovered the Kaposi’s sarcoma-associated herpes virus, or deception. But while Aesop’s moral was meant to teach the evils of KSHV, 10 years ago. Dr. Moore, a professor of molecular genetics deception, this children’s tale also serves as a good analogy for how and biochemistry, and Dr. Chang, a professor of pathology, joined some viruses may fall victim to their own deception through a twist UPCI in 2002 to continue their study of KSHV and other cancer- of biological fate. causing viruses.

Researchers at the University of Pittsburgh Cancer Institute (UPCI) are studying how viruses, by assuming human genes that allow them Anatomy of a cancer to take advantage of the body’s inner workings, can sometimes bring mutual disaster to themselves and their hosts. In its rush to mimic About 3 percent of the U.S. population is infected with KSHV. Most human cells, a certain virus has been found to cause cancer, resulting will never suffer any serious side effects from the infection. In some in harm to both healthy tissue as well as the virus. Mediterranean populations, the infection rate rises to 10 to 15 percent. In sub-Saharan Africa, it’s as high as 40 to 60 percent. Husband-and-wife research team Patrick S. Moore, MD, MPH, and Yuan Chang, MD, study the interaction between the virus that causes Why does the virus infect so many people and cause cancer in so few? Kaposi’s sarcoma — an otherwise rare form of bone and muscle The answer to that question has taught Drs. Moore and Chang, and cancer that is common among AIDS patients — and the defenses it their colleagues around the world, a lot about how cancer develops, must overcome to flourish in our bodies. and how doctors might shortstop that development.

Continued

2 UPMC Cancer Centers University of Pittsburgh Cancer Institute 3 You have to have a whole battery of techniques or “technology at your disposal for hunting new viruses.” From the beginning, it seemed clear that KSHV caused cancer only when another factor — such as the AIDS virus, chronic malnutrition, immunosuppressive treatment, or advanced age — compromised the infected person’s immune system. In its evolution, Drs. Moore and Chang discovered that KSHV had stolen bits of the human genome — the DNA in our chromosomes — in order to subdue the body’s ability to fight it off, and encourage the cells it infects to make new Among viruses, KSHV virus particles. has the most extensive These stolen genes read like a “Who’s Who” in cancer formation, run- repertoire of pirated genes. Patrick S. Moore, MD, MPH ning the gamut from genes that control cell division (necessary for viral growth) and programmed cell death (a defense against viral infection that the virus must turn off) to genes that control the immune system’s But interestingly, the newcomer uses completely different genes to do it. Finding new viruses is a tough task even today, Dr. Chang observes: response against viruses (again, necessary for the virus to turn off). In one fell swoop, the new virus identifies a batch of human genes that “We’re still only able to culture a small fraction of microbes out there.” plays a major role in tumor development and tumor suppression. There have been “Among viruses, KSHV has the most extensive repertoire of pirated RDA is both a subtle and brute-force method: You take a tiny genes that we know of,” says Dr. Moore. And when another factor, The virus also shows the researchers why different cancer viruses act amount of DNA from a Kaposi’s tumor, and a tiny amount from such as immune suppression, enters the picture, this fearsome array differently. As Dr. Chang says, “We were all aware of the big splash healthy tissue in the affected person. You match up the two and plenty of big break- of counterfeit genes runs out of control: The same genes that helped made when the gene that causes cystic fibrosis was discovered.” In then expand the DNA sample using a process that only reproduces the virus reproduce suddenly free the infected cell of the body’s cancer, though, “… it’s not one specific gene; there are many genes the sequences that are different. The different DNA, if any, is by throughs … these controls over cell growth and movement — in other words, they that contribute. In addition, there are environmental factors.” definition alien to the host. So it must come from the virus. “ make it cancerous. The big question, Dr. Chang says, is whether all of these genes and Drs. Moore and Chang still can’t believe their luck. The RDA breakthroughs need The researchers found that the genes stolen by KSHV hit the cell in factors are “created equal,” or some are more important for cancer process was a difficult, six-week procedure. But on the first try, it pretty much the same places as previously discovered tumor viruses. formation. If the latter, those “master switches” would be particularly identified DNA fragments that belonged to KSHV, allowing them to be exploited. good targets for anticancer therapy. The relationship between KSHV to isolate and sequence the rest of the virus. and other tumor viruses suggests that the latter is true. Still, Dr. Moore is philosophical about the way KSHV has driven “That explains why every virus affects the cell differently,” Dr. Chang adds. their careers: “In science, you have to follow up the big questions The couple would also like to see their KSHV work pay off in new that need to be answered, rather than just answering the questions cancer therapies. you think you can.” Casting a broad net “There have been plenty of big breakthroughs in the ”field; I think Neither of the two scientists began their careers with a particular interest Continuing the search these breakthroughs need to be exploited,” Dr. Moore says. “We’re in tumor viruses or Kaposi’s sarcoma. Dr. Moore had been studying at such an important stage in cancer virology. We have the entire bacteria-caused meningitis epidemics in Africa; Dr. Chang had worked As perhaps befits a research effort led by a married couple, their human genome; in theory we know every gene. We can look on the pathology of brain tumors and other brain diseases. laboratory has a dual personality: half continuing to study KSHV at cells from various cancers in many, many different ways. But in depth, and the other half using RDA and newer methods to obviously, we haven’t found all the answers.” But in 1993, the pair — he working for New York City’s public health discover more viruses. department, she for Columbia University — read about a new virus- The support available at UPCI drew Drs. Moore and Chang to discovery technology called representational difference analysis, or RDA. “You have to have a whole battery of techniques or technology at Pittsburgh. And it’s that environment that continues to drive They began to wonder if the method might work to isolate the Kaposi’s your disposal for hunting new viruses,” Dr. Chang says. This work their work. “UPCI has unique intellectual resources that can take virus, which researchers couldn’t find but believed existed, despite two is very much still in progress, but may teach more lessons about how advantage of the current state of science in cancer biology. But the decades of searching. viruses infect cells — and, thus, how those cells work. Subsequently, comprehensive support — from administrators all the way down this teaches important lessons about how the infected cells misfunction to donors — has been absolutely critical.” I in cancer. Yuan Chang, MD

4 UPMC Cancer Centers University of Pittsburgh Cancer Institute 5 Beyond the X-ray Normal CT scan Spiral CT scan with identified tumor

A spiral CT scan, which Spiral CT opens new early detection possibilities for deadliest of cancers. takes about 15 seconds, can produce a much higher quality image, making detec- Sometimes a medical advance solves a problem but creates a challenge of its own. In the case However, after his initial spiral CT scan revealed a suspicious-looking nodule, he underwent tion of tumors easier. of lung cancer screening, new imaging technology called spiral CT (computed tomography) two additional scans. The nodule eventually was determined to be cancerous, and because the can detect very small pulmonary nodules, or tiny lung tumors, that are not detected by chest cancer was extremely localized, the tumor was removed using minimally invasive surgery. It’s x-ray. It’s a remarkable development that may allow physicians to detect and treat lung cancer highly unlikely MacLeod would have enjoyed such a positive outcome had he not participated at its earliest stages, before it can grow and spread. in the study. “I ended up benefiting from my own good spirit,” he says.

“Spiral CT is an emerging technology that opens a new realm of exciting possibilities for the A major advantage of spiral CT is speed. Whereas images from older screening technology early detection of lung cancer,” says Joel Weissfeld, MD, co-leader of the Cancer Epidemiology, are distorted because of patient breathing, images produced by spiral CT are of much higher Prevention, and Control Program of the University of Pittsburgh Cancer Institute. quality because the scan takes between 15 to 20 seconds and is performed while the patient holds his or her breath. However, doctors who use spiral CT face the challenge of determining whether the newly visible nodules are cancerous, precancerous, or nonthreatening. In fact, critics argue that the Nonetheless, predicting the behavior of the pulmonary nodules revealed by the new technology technology produces too many false-positive test results. The University of Pittsburgh Cancer and, ultimately, whether the nodules pose a threat to the patient, remains an important Institute is leading efforts to understand the physiology of the small tumors so that doctors can research issue. more easily distinguish the threatening tumors from the harmless ones. To that end, Dr. Weissfeld also is the local principal investigator in a related national study Joel Weissfeld, MD, co-leader Through the Pittsburgh Lung Screening Study (PLuSS) — a project led by Dr. Weissfeld as of the effectiveness of spiral CT scans compared to chest x-rays. The University of Pittsburgh of the Cancer Epidemiology, a component of the prestigious Lung Cancer Specialized Program of Research Excellence Cancer Institute is one of only 10 centers in the United States participating. Prevention, and Control Program, (SPORE) that is funded by the National Cancer Institute — current or former smokers between is leading efforts to understand 50 and 79 years of age are screened using spiral CT and are monitored for several years for “The extent to which these newly visible pulmonary nodules are a cancer risk is still unknown,” the physiology of the small changes in pulmonary nodules. says Dr. Weissfeld. “It’s our hope that these trials may ultimately yield the answer.” I tumors found through spiral CT, to distinguish the cancerous Nearly 3,100 people regionally have enrolled in PLuSS since the study opened in 2002. Based from the harmless tumors. on the screenings, several hundred people were suspected of having lung cancer and, of those, 34 were diagnosed with the disease.

Among them is Allan MacLeod. A resident of Beaver County, just west of Pittsburgh. Mr. MacLeod enrolled in the study because he wanted to help advance state-of-the-art medicine. Mr. MacLeod was completely healthy by all outward appearances.

6 UPMC Cancer Centers University of Pittsburgh Cancer Institute 7 When Dwight Heron, MD, and Keith Morgenlander, MPH, developed a proposal for a grant from the National Cancer Dwight Heron, MD, and Keith Morgenlander, MPH, Institute (NCI) to break down the barriers that impede access to radiation services and innovative clinical trials involving have joined forces to break down racial and radiation therapy for rural and minority cancer patients, it was more than an academic and intellectual pursuit. socioeconomic disparities in cancer care, specifically radiation therapy. Breaking Down Barriers Personal experience driving force behind disparities initiative

Driven by a personal commitment to the “Every day, I see patients who are unable cultural, and socioeconomic factors that “What makes this grant most unusual is Other examples of innovations within the while two additional cancer centers, Roswell fundamental right for equality in cancer to take time off work to make it to radiation limit access to these services.” that it includes academic and community- grant include creating a neighborhood- Park Cancer Institute in Buffalo, N.Y., and care, Dwight Heron, MD, and Keith therapy appointments or who have family based hospitals, local and national partners, based cancer survivor buddy system, the Mallinckrodt Institute of Radiology at the Morgenlander, MPH, are leading a five- obligations that keep them from receiving Statistics from the NCI confirm Dr. Heron’s and community and faith-based groups,” assisting with child or senior care during Washington University School of Medicine year, $5 million grant from the National the care they need to overcome cancer.” and Mr. Morgenlander’s assessment and says Mr. Morgenlander. “We focused on treatment, developing a telemedicine sys- in St. Louis, act as mentors in the project to Cancer Institute to address racial and His colleague, Mr. Morgenlander, assistant indicate that African American men develop the patients’ needs and put the control of tem to provide real-time care consultation advise in the design of ongoing clinical pro- socioeconomic disparities in radiation professor of hematology/oncology at the cancer 15 percent more frequently than the project as close to the community and with local, national, and international grams and community outreach efforts. therapy in partnership with UPMC University of Pittsburgh School of Medicine white men; many ethnic minorities have patient as possible.” experts at other centers, and creating a McKeesport. This community hospital, and coordinator of outcomes and dispari- much poorer survival rates than whites. comprehensive quality assurance and Other partnerships with key community located southwest of Pittsburgh, is the ties research at University of Pittsburgh According to the NCI, much of the disparity According to Dr. Heron and Mr. Morgenlander, improvement system to ensure the quality and faith-based organizations include the hub of the study and one of only four Cancer Institute and UPMC Cancer Centers, in cancer outcome is a reflection of type, one of the most unique projects within the of care and to monitor treatment disparities. Consumer Health Coalition of Greater hospitals across the country to receive is the grandson of Russian immigrants timeliness, and continuity of care rather grant is a rural transportation program to Pittsburgh, the Center for Healthy Hearts the grant this year. who came to the United States to escape than the disease itself. When patients from bring patients into appointments and to ROCOG, based at UPMC McKeesport, and Souls, and the University of Pittsburgh the pogroms there. Mr. Morgenlander says different racial, ethnic, and socioeconomic house elderly and disabled patients. includes Jameson Hospital in New Castle, Graduate School of Public Health’s Center groups receive the same quality of care, Pa.; Mercy Hospital in Pittsburgh; Somerset for Minority Health. Susan Rafkal, MD, that he learned a keen sense of social jus- I their outcomes are similar. “Women with breast cancer are four times Hospital in Somerset, Pa.; Allegheny Cancer a UPMC Cancer tice early on from his father, who ran a more likely to have a radical mastectomy Institute at Somerset; and UPMC Lee Centers radiation child psychology clinic in the Hill District Dr. Heron and Mr. Morgenlander are using than breast-conserving surgery when they Regional and UPMC Cancer Center, John P. oncologist, is the of Pittsburgh. the grant from NCI to head up a project, can’t physically make it to appointments Murtha Pavilion, both in Johnstown, Pa. clinical leader of “While disease and hardship can affect aptly named the Radiation Oncology for radiation treatment,” Dr. Heron says. The University of Pittsburgh Cancer Institute, the ROCOG grant at every one of us, we are affected differently,” Community Outreach Group (ROCOG), that “If we can provide something as basic as Allegheny Cancer Institute, and the National UPMC McKeesport. says Mr. Morgenlander. “Real barriers to consists of a consortium of five hospitals, transportation, we can significantly improve Adjuvant Surgical Breast & Bowel Project care exist, and studies demonstrate that three health systems, several community- recovery time and quality of life for these provide locally-based academic support the burden of cancer is too often greater based organizations, and local health care patients.” providers to improve access and clinical “As a minority myself, I am deeply com- for the poor, ethnic minorities, and the outcomes for racial and socioeconomically mitted to changing people’s perceptions uninsured.” disadvantaged populations with cancer. and improving trust between physician and Dr. Heron agrees. “A number of barriers, patient in order to improve access to the both real and perceived, hinder minorities The key goal of the grant is to use non- care they deserve,” says Dr. Heron, who is and economically disadvantaged populations traditional outreach to make innovative assistant professor of radiation oncology from receiving much-needed radiation clinical research studies, including radia- We focused on the patients’needs and at the University of Pittsburgh School of services for cancer and from accessing tion therapy, available to underserved Medicine and vice chairman of radiation clinical trials. This NCI grant allows us to populations, specifically the economically put the control of the project as close oncology at the University of Pittsburgh provide radiation services to patients and disadvantaged as well as African American Medical Center. communities with the greatest needs and minority populations. to the community and patient as possible. will help address and overcome geographic, 8 UPMC Cancer Centers “ University of Pittsburgh Cancer ”Institute 9 Professional golf great Greg Norman (center) served as honorary celebrity chair for the event. Pictured with Mr. Norman are Honorary Chair Henry Hillman (left) and Joe Hardy, president and founder of 84 Lumber Through the leadership (right), sponsor of the online auction. of event general chairs Markos and Pamela Tambakeras and Mikell and Bill Schenk, the Hope Takes Flight gala was the most successful fund-raising event ever for UPMC Cancer Centers and UPCI. Philanthropy Soars at Honorary Chair Elsie Hillman, with UPMC President Jeffrey Romoff (left) and Mark E. Pasquerilla (right), announced a $1 million commitment by Mr. Pasquerilla Annual Cancer Gala to fund cancer genomics and proteomics research. Hope Takes Flight event raises $4.2 million for cancer research and patient care.

On Nov. 4, 2004, 870 guests joined hon- Throughout the evening, celebrations of by Mark E. Pasquerilla to fund research on Through the generous support of orary chairs Elsie and Henry Hillman and cancer survivorship, heartfelt reminders of cancer genomics and proteomics, research that many individuals, corporations, and celebrity chair and golfer Greg Norman for special people who lost their battles with could have a revolutionary impact on early businesses, we are working toward a “Hope Takes Flight … A Future Without cancer, and interviews with compassionate diagnosis and treatment of cancer. future without cancer. Special thanks The late Jerry Orbach, legendary star Cancer,” a gala fund-raising event that physicians underscored the critical nature to our lead donors, including: of stage and screen, lent his support raised $4.2 million to support world-class of the Hillman Cancer Center’s mission. The event, presented by PNC and the Uni- to the evening’s events. Mr. Orbach, Extraordinary Leadership Gift research and patient care at Hillman Cancer “The evening was a time to celebrate and versity of Pittsburgh Medical Center (UPMC), who succumbed to prostate cancer featured for the first time an online auction Wheeler Brothers, Inc. on Dec. 28, 2004, sang the classic Center, the flagship facility of UPMC take great pride in our world-class institution hosted by eBay. The auction, sponsored by Leadership Gift “Time to Remember” from the Broadway Cancer Centers and the University of that provides the finest in cancer research 84 Lumber Company, provided a unique Amgen hit, The Fantastiks, in tribute to those Pittsburgh Cancer Institute. and patient care,” Mr. Hillman said. “It also opportunity for others throughout the United affected by cancer. He is pictured was an opportunity to rededicate ourselves Presenting Sponsors Building on the theme of flight, an airport States and the world to lend their support to with his wife Elaine (left) and donor to the very special cause of curing cancer, The PNC Financial Services Group hangar was transformed into a magical the event’s cause. Debi Wheeler (center). a disease that touches all our lives.” University of Pittsburgh Medical Center banquet hall, resplendent with vibrant fall colors and glowing hurricane lanterns to Wheeler Brothers, Inc., ambitiously launched Numerous individual donors joined Ronald On-Line Auction Sponsor give the room an intimate feel. While fund-raising efforts by creating a $1 million Herberman, MD, director of UPCI and 84 Lumber Company UPMC Cancer Centers, UPMC President enjoying a five-course dinner, guests were “challenge grant,” encouraging other indi- Leadership Jeffrey Romoff, and University of Pittsburgh treated to unique vignettes of entertainment vidual and corporate leaders to participate Blue Cross Blue Shield by Broadway performers Marcus Lovett, in a collective match of their generous phil- Chancellor Mark Nordenberg for this special Visionary Michele Pawk, and Billy Porter, as well as anthropic contribution, which helped to evening, including: University of Pittsburgh Aventis Oncology Jerry Orbach, star of stage, screen, and vault fund raising to the highest level ever Cancer Institute Advisory Council Chair Sy television, accompanied by a full orchestra. for the gala event. Holzer, president of PNC Financial Services Alice and Frank Bittner and Between courses, aerial acrobats dazzled Group; general chairs of the event, Pamela Gateway Travel Plaza the crowd with feats of amazing strength, In addition to funds raised in conjunction and Markos Tambakeras and Mikell and Bill The Hillman Company agility, and grace. with the gala, Elsie Hillman used the occa- Schenck; advisory chairs Tricia and Bill Varian Medical Systems sion to announce a $1 million commitment Kassling, and co-chairs, Bonnie and Tom VanKirk and Susan and Michael Boyle.

10 UPMC Cancer Centers University of Pittsburgh Cancer Institute 11 UPMC Cancer Centers has grown to become one of the largest clinical “ care networks for cancer in the country. Greenville •UPMC Horizon State-of-the-Art •LCCC ” •Shenango Valley Cancer Care Close toHermitage Home

New Castle became more difficult for Ms. Paxton as • her treatment progressed and side effects of fatigue and nausea worsened. “There were a lot of stops on the way home,” she says.

Ms. Paxton is just one example of the Armstrong Co. The Medical •Memorial compromises many cancer patients once had Center, Beaver Hospital • •Cranberry to make to receive high quality cancer care. Beav•er Alle-Kiski Valley• Now patients can receive care right in their Wexford Indiana • UPMC Passavant Nat•rona • • Heights When Debbie Paxton was diagnosed with own community. Recognizing the need of Sewickley cervical cancer in October 2001, she want- cancer patients in western Pennsylvania, the Moon• UPMC St. Margaret • Monroeville/Mosside ed the best care available. Unfortunately, University of Pittsburgh Medical Center Kennedy • • Mon••roeville/ Pittsburgh Haymaker that meant four hours of driving each day and the University of Pittsburgh Cancer Weirton Upper •Medical St. Clair ★ Center • St. Clair to Magee-Womens Hospital of UPMC Institute have partnered with local commu- Hospital Steu•benville • Jeannette Johnstown Sout•h Hills UPMC• McKees•port John P. Murtha in Pittsburgh to receive a state-of-the-art nity hospitals to bring its world-class cancer •Pavilion Greensburg treatment that wasn’t offered in her care to patients in their communities. Since • Latrobe Area Hospital Greensburg• Arnold Palmer Johnstown community. “The traveling its inception in 2001, UPMC Cancer •Pavilion Windber- added to the anxiety and stress of treat- Centers has grown to become one of the •Somerset • Washington Mt. Pleasant ment. It made it much worse for me,” largest clinical care networks for cancer in • says Ms. Paxton, whose family and friends the country, treating more than 30,000 drove her to and from Pittsburgh nearly patients each year at 43 locations. Highlands• Hospital 35 times in six weeks. The constant driving

Continued •• Uniontown

12 UPMC Cancer Centers University of Pittsburgh Cancer Institute 13 • •

•

•

• •• • • • •• • • • • • •• • • ★ • • As the “hub” of the network, Hillman Cancer Center houses both research facilities and outpatient clinical care. Using a hub-and-spokes• • concept,• we’re able to extend the expertise of UPCI • researchers and clinicians — housed• at the • “ Hillman Cancer Center — to more than 40 locations• throughout western Pennsylvania. • In short, patients throughout the region supply, IMRT typically is available only at that are offered exclusively through • now have convenient access to cancer large academic research centers. However, major academic research centers such treatments that• were previously not avail- through telemedicine capabilities, physi- as UPMC Cancer Centers and the able outside major university medical cists based at the Hillman Cancer Center University of Pittsburgh Cancer Institute, centers. “Our more than 80 affiliated are able to provide IMRT treatment plan- the only National Cancer Institute-desig- oncologists are able to collaborate with ” ning services for 11 community locations nated Comprehensive Cancer Center in the internationally-renowned experts at throughout western Pennsylvania, includ- western Pennsylvania. Clinical trials may UPMC Cancer Centers community physicians UPMC and UPCI• and draw upon the full ing UPMC Cancer Center, John P. give patients a new lease on life when can now offer their resources available there,” Dr. Shogan notes. Murtha Pavilion, in Johnstown, only five standard therapies have failed. patients the most innovative treatments minutes from Ms. Paxton’s home. through clinical trials For example, the treatment Ms. Paxton As UPMC Cancer Centers continues available through the received, called intensity modulated radia- “It thrills me to know that someone who to enhance its clinical care network, University of Pittsburgh Cancer Institute. Intensity modulated “Using a hub-and-spokes concept, we’re tion therapy, or IMRT, is a revolutionary is diagnosed with cancer is now able to even more patients will benefit from radiation therapy can literally “sculpt” the able to extend the expertise of UPCI new way to deliver high doses of radiation drive five minutes and have peace of the local presence of a national leader in contours of a tumor researchers and clinicians — housed at the to pinpoint cancerous locations, sparing mind knowing they’re getting the same cancer care. “When I was first diagnosed with radiation, dra- matically reducing Hillman Cancer Center in the Shadyside • nearby healthy tissues and organs and treatment as they would in Pittsburgh,” with cancer, I immediately thought it harmful side effects. section of Pittsburgh — to more than 40 • dramatically reducing harmful side effects. Ms. Paxton says. was a death sentence. It absolutely is locations throughout western Pennsylvania,” Because the highly specialized physicists not,” Ms. Paxton says. “Now others Through this affiliation, patients now also says Jeffrey Shogan, deputy director of clin- who perform the complex IMRT treat- have a much easier road to the most have convenient access to the most inno- ical business affairs, UPMC Cancer Centers. ment planning are in extremely short advanced care.” I vative treatments through clinical trials

14 UPMC Cancer Centers University of Pittsburgh Cancer Institute 15 Riggs Family Victoria and John M. Duff Jr. Margaret S. and Robert G. Runnette Carolyn and Bryan Hunt The Power of Annie and Richard F. Rivers Jr. Lowrie C. Ebbert Cynthia and Keith “Kim” Schappert Dale B. Keller Roesch Family Sally and Terry Evans, MD Steven H. Seitchik William J. Koessler Abby and Reid W. Ruttenberg Mary Ellen and Robert L. Shema Frances and Stewart L. Lancaster, MD Partnership Mikell and A. William Schenck III William A. Ferri Jr., MD Jackie and Jeffrey Shogan, MD Laverne E. Larusch Karen A. and David S. Shapira Rozanne and Edward J. Flammer Juliet Hillman and John Todd Simonds Maureen Simon Leckenby Edith Shapira, MD, and Mark Rebecca Garrett, MD Lea Hillman Simonds Charles U. Lowe, MD and Kenneth Foon, MD Schmidhofer, MD Alice Snyder Terrie L. and T. H. Emery Cheryl and Timothy Freer Pamela and Markos Tambakeras Patricia and William I. Snyder Annette and Gary Luchini UPMC Cancer Centers and the University of Pittsburgh Cancer Institute deeply thank our partners, the hundreds of individuals, Michelle and John A. Freyvogel III Gayle L. Tissue and Susan and Holly W. Sphar Jr. Paul L. Maguire families, businesses, corporations, foundations, and organizations that have supported our patient care, education, and cancer research Yiannis Kaloyeropoulos Sally and Thomas B. Golden Jr. Terri Ann and Matthew Sulecki Katherine C. and Albert E. Maroone efforts during the fiscal year ending June 30, 2004. Every gift helps our institutions to thrive and maximize every opportunity and Bonnie W. and Linda and Edward M. Goldston Judith Evans Thomas Dr. Arthur M. Mettelman advantage for patients and their families. Each gift demonstrates a profound faith in the work that we do. Thomas L. VanKirk, Esq. Marie and Robert Gray Marilyn and Norman B. Weizenbaum Saralyn S. Vogel, MD, and Alexander C. Meyer Jr. Mary Jane and Carl Grefenstette Victor G. Vogel, MD Joan and Harold W. Wheeler Jr. Ann R. and Richard B. Meyer Endowments Annual Giving Sher Leigh and Gary Grelick Janet A. Wagner Debi and Pete W. Wheeler III Sam Michaels An important number of endowed chairs and funds support our mission. The The Annual Fund provides a broad scope of vital support for the operation of Mary Anne and Howard W. Hanna III Susan E. Weintraub Jennifer and David Wheeler Constance and Bruce Morrison income generated from endowments provides solid support and will continue to clinical programs, basic and clinical research programs, recruitment of new physi- Doris and Jules Heisler, PhD Jane and S. Rand Werrin, DMD fuel many new initiatives into the future. These funds enable our scientists and cians and scientists, seed money support, medical and patient education, and out- Stacy and Paul Wheeler Kim and Michael Neal Sarah and C. Talbot Heppenstall Jr. Leon Wong clinicians and their teams to strengthen and expand many of the established areas reach programs. UPMC Cancer Centers and the University of Pittsburgh Cancer S. Donald Wiley Mary and Gerald O’Connor of expertise, as well as forge new frontiers in science that benefit our patients and Institute gratefully acknowledge gifts that have been given from July 1, 2003 to Ruth A. Zittrain, Esq. Sang C. Park, MD their families. June 30, 2004 through the following recognition societies. Membership “Too many people have suffered because of cancer. Someday Laure Croiselle-Peault, MD, PhD is a result of sustained annual investments at these designated levels. and Bruno M. Peault, PhD The Claude Worthington Benedum The Bernard Fisher Endowed Chair Leadership Circle we will come up with that cure, but it’s going to take time Endowed Chair in Radiation Oncology in Surgical Oncology ($5,000-$9,999) Marilyn and and it’s going to take people committed to supporting the Thomas J. Quatroche Sr., MD Richard M. Cyert Endowed Chair in The Foundation Endowed Circle of Hope Harriet L. and Penny and Charles Alpern Molecular Oncology Chair in Cancer Genetics The Circle of Hope was established Ronald B. Herberman, MD Frances and Charles Cost researchers and doctors hard at work combating this disease.” Susan M. Rakfal, MD Gregory T.H. Davies Brain Tumor Stuart Goodman Brain Cancer in 2002 to honor individuals, family Elsie H. and Henry L. Hillman Mary Jane E. and Richard Cohen, Circle of Hope donor David W. Reinhart Research and Physician Education Memorial Fund foundations and privately held compa- William T. Hillman Richard D. Edwards, PhD Spring Hill and Robert W. Riordan Endowed Fund nies that make contributions of The Hillman Endowed Chair Robert E. Johnson Ranny and Jay Ferguson III Joan and Bernard Roach The Lawrence Ellis Endowed Chair in Oncology $10,000 or more during the course Rachel Leia and Shalom Kalnicki, MD Virginia M. and Richard L. Fischer Champions ($500-$999) in Hematology and Oncology of a calendar year. We proudly recog- Mark R. Hoover Jeanette and Harvey W. Rosenberg, MD Loretta and Victor Adragna nize all donors for 2003 as well as Tricia and William Kassling Carmella King and Family Sally Imbriglia Barbara and John Rumschik Vincent Amon Visionary Society those for the first part of 2004. James Kelley Mary Knowles and Jean and Samuel A. Jacobs, MD Marilyn and Richard J. Saab, MD Oliver McClintock Jr. Anonymous UPMC Cancer Centers and the University of Pittsburgh Cancer Institute Jane K. France and Christian L. Allison Christopher H. Koch Lynda and Robert S. Jamison, Jr. Nancy and Robert E. Schoen, MD, MPH Peggy and Steve McKnight Dr. Catherine Ansuini gratefully acknowledge those dedicated partners with a passion for conquering Billy N. Appel, DDS Valerie R. Koch Constance and Carl Kalberkamp Mark G. Schoeppner cancer in our lifetime who have given or helped to raise a cumulative total of Kathleen Welsh McSorley Kimberly and Peter Augustine Dorothy B. and G. Nicholas Beckwith III Charles R. Lee Irene and Kevin M. Kane, MD Marina and Jon Scott $1 million or more. Amy and Sean Sebastian Denise and Raymond Barry Mernie Berger Nathalie and Mario Lemieux Susan and David M. Kelly Barbara A. and M. Alfred Seltman, DMD Barbara and Herbert Shear Thomas H. Brown Anonymous Mario Lemieux Foundation Minette D. Bickel Robert Levin James E. Kelly, Esq. Katharine H. Servick Susan Santa-Cruz and Tracy Seewald, MD, and The Giant Eagle Foundation Richard King Mellon Foundation Alice and Frank Bittner Sally Levin Jan and Gauri J. Kiefer, MD J. Michael Shane Arthur Stroyd Jr. Esq. Steven A. Burton, MD Elsie H. and Henry L. Hillman PNC Financial Services Group Susan C. and Robert J. Brooks Scott Limbach Nancy and Richard D. Krieger Samuel J. Simon and and PNC Foundation Mr. and Mrs. E. Ross Cervick The Henry L. Hillman Foundation Barbara and Gerald E. Chait Christine and James D. Luketich, MD Partners for Progress Cynthia Roth and James Kunkel, MD William N. Macartney III Wheeler Brothers, Inc. Dr. and Mrs. Thomas R. Crain Jr. Family and Friends of Albert P. Knowles Sandra S. and Richard A. Cohen Ellen and Stanley M. Marks, MD ($1,000-$4,999) Mary Beth and Christopher Leech Hynda and Thomas W. Storm Douha Safar, MD James S. Davis Family and Friends of David C. Koch Barbara Ann and Robert A. Crown Helen Fricke Mathieson Julia and Scott A. Lewis Lisa and Peter Walsh and Mounzer Agha, MD Joan and John Diederich Randi and L. Van Dauler Kenneth S. McCarty, MD, PhD Evelyn D. and Felixberto D. Lim, MD Shirley and George Weaver Family Legacy Society Anonymous Bernadette and Thomas Duffy Barbara and Randy Davies The Moravitz Family Judith K. and Elizabeth and Robert B. Weidlein Motivated by a personal experience with cancer or by the loss of a loved one to Edson “Ted” R. Arneault Wyndham Eaton Lauren S. Flannery Theresa Whiteside-Nimick, PhD, Ronald Linaburg, DMD, MS Susan Weintraub Rashid A. Awan, MD Lynn and Lance Farber the disease, these families have been instrumental in generating significant support and Thomas H. Nimick Jr. Alexis Megaludis, MD Marcia J. Weiss for patient care, education, and cancer research programs. Their extraordinary Stephanie and Thomas Flannery Arthur W. Banwell Peggie and Jack Offenbach Emily Mendelson George A. Fechter efforts are an inspiration to all of us. UPMC Cancer Centers and the University of Kim H. and Curtis D. Fleming David S. Williams Saundra K. and Eugene J. O’Sullivan Susan and David Bartlett, MD Kathryn and Mark Gaier Pittsburgh Cancer Institute gratefully acknowledge the support from these Cara and Chip Ganassi Natalie Moritz, Esq. and families who have begun the following named funds. Lisa and Mark E. Pasquerilla Barbara A. Dappert, MD, and J. Kenneth Moritz, Esq. William Harrison Genge Ambassadors ($250-$499) Ellen R. Goodman Michael J. Becich, MD, PhD Leah M. Pasquerilla Barbara and Eugene N. Myers, MD Sandra and Lee S. Goodman Anonymous Nathan S. Arenson Fund for David C. Koch Memorial Fund Susan G. and Barney C. Guttman Patricia G. and Sanford S. Berman Cheron and Bruce Barton Pancreatic Cancer Research Cindy and Brian W. Patten Cathy and Michael A. Nalesnik, MD Thomas G. Granville Mario Lemieux Patient Care Maggie Hardy Magerko Marilyn and Guy P. Berner Ann H. Berger Patti Burns Fund and Cancer Research Fund Hilary T. and Charles M. Porter Noel Marie Newell Carolyn and Adam Green Teresa Kerry Jill Brufsky, Pharm D, Mary and Gerard O’Connor Daniel L. and John R. Greenwood Carol Weiss and Arnold A. Berger Grant Channell Memorial Fund Scott Limbach Entrepreneurial Center and Adam Brufsky, MD Brian J. O’Mara Ruth and Christopher Groven Charles Brown, MD, PhD Dr. Joan G. Gaines Breast Cancer Drew Mathieson Entrepreneurship Fund Sally and J. Mabon Childs Research Fund “Cancer research is going to be the salvation for the next Faith and Barry Pennypacker Mary Ann Harding Nancy and Edward G. Byrnes Jr. PNC Innovation Fund Robert E. Cline Peter E. Hackney Fund for Pancreatic generation. This disease is so insidious that it’s going to take Lois and John Pfohl Georgia V. Harrison Maureen Laney and Dan Clarke Michael J. Parada Research Fund Julie and John Conway Cancer Research Edward G. Piwowarczyk Mary L. Dorfner and Stephen S. Hay Elisa D. Harris and Ivo H. Daalder Mark E. and Leah M. Pasquerilla researchers to defeat it, and it’s going to take people supporting Patty and James C. Dewar Dr. Herb E. Jacob Memorial Fund Women’s Cancer Research Fund Patricia and Evans Rose Jr., Esq. Susan and David Hicks Jane P. and Frederick C. Duffy Jr. the researchers.” William S. Dietrich II Barbara Klump Memorial Dr. Leonard S. Zombek Memorial Fund Nancy Rozendal Tracy and J. Craig Hill Patricia and John K. Duggan Jr. Scholarship Fund Valerie Koch, Family Legacy Society donor Susan and The Honorable Michael Doyle Albert P. Knowles Research Fund

16 UPMC Cancer Centers University of Pittsburgh Cancer Institute 17 Mary Ruth Sampson Eckman Estates and Trusts Codman & Shurtlett Immunologic Cellular Products Matthew Hillman Fisher Foundation The Russo Family Charitable Trust Laboratory Staff Foundation Inc. Elizabeth and Paul Euwer Jr. UPMC Cancer Centers and the Coit Services, Inc. “Having been blessed to survive melanoma, I determined, when Merrill Lynch and Company Independent Health Association, Inc. Foundation The V Foundation for Cancer Research Robert Louis Ferris, MD University of Pittsburgh Cancer Coldwell Banker Residential it was possible, to support the seemingly insurmountable fiscal Brokerage Corp. Intermodal Air, Incorporated Meyer and Merle Berger Family The Weintraub Family Michelle L. Filipiak Institute gratefully acknowledge task of helping to spare others the suffering and loss that so gifts from the following individual Construction General Laborers & International Brotherhood Of Foundation, Inc. The William Talbott Hillman Mary L. and Joseph F. Francis often comes with this type of cancer.” estates and trusts. Material Handlers Electrical Workers Microsoft Foundation Foundation, Inc. Ethel and Edward Fritsch Estate of John J. Shagovac Cost Company Jaeckle Fleischmann & Mugel, LLP Robert Johnson, Cancer Foundation for Melanoma Research Muse Foundation Tippins Foundation Leslie Alan Goldstein, PhD Estate of Florence K. Williams Co-Workers of Howard Ginsburg at Jobs Weekly, Inc. N.S.A.B.P. Foundation, Inc. United Jewish Federation of Greater Jennifer Grandis, MD, and United Guaranty John Hancock Financial Services, Inc. Nina Baldwin Fisher Foundation Pittsburgh Donald J. Grandis, MD Businesses, Corporations, Phillips Lytle, LLP Zambelli Fireworks Manufacturing Co. Creative Displays & Packaging, Inc. Johnson & Johnson , Incorporated Katherine and W. Penn Hackney Advocacy Associations, Pittsburgh Associates () Zenner & Ritter, Inc. In-Kind Donations Crown Hotel Investments, L.P. Jonette Jewelry Company PNC Foundation Lisa and Mark Hardy and Other Groups Pittsburgh Life Sciences Greenhouse Zweigle Advertising, Inc. UPMC Cancer Centers and the CTR Holdings, Inc. KDKA-TV/WNPA-TV Richard King Mellon Foundation Mary L. and Thomas M. Hill UPMC Cancer Centers and the Pittsburgh Steelers Sports, Inc. University of Pittsburgh Cancer Dane Electric Co. Ladies Hospital Aid Society of Western Foundations Robroy Industries Institute gratefully acknowledge Nancy Tseng Ho and Chien Ho, PhD University of Pittsburgh Cancer Pittsburgh Surgical Specialists, Inc. Delta Mills Marketing, Inc. Pennsylvania Institute gratefully acknowledge the UPMC Cancer Centers and the Shadyside Hospital Foundation each donor group that has provided Harold W. Hunsiker PNC Advisors an in-kind donation of $500 or following gifts of $250 or more from DHJ Canada, Incorporated Lake Shore Properties Inc. University of Pittsburgh Cancer Sisterson and Company LLP Hannah and Marvin Kamin PNC Bank N.A. Institute gratefully acknowledge the more to further our mission. businesses, corporations, advocacy Ditto Document Services Inc. Lawley Service Insurance Snee-Reinhardt Charitable Foundation Timothy L. Kane PNC Financial Services Group s associations, and other groups. Levin Furniture foundations that have provided Apple Box support of $250 or more to further Soap Sisters Julie A. Koch Polakoff Sports Sales Inc. Tony Bennett Anonymous Eagle Buckram Co., Inc. Lexus of North Hills our mission. Stork Foundation Lori and Robert Lauth PremCom Corporation Continental Dukes AFLAC Easley & Rivers, Incorporated Lia Agency, Inc. Susan G. Komen Breast Cancer Patricia and Thomas C. LeClere Pricewaterhouse Coopers LLP Adrienne and Milton Porter Alabama Power Company Electralloy Accounting Department M&T Bank Charitable Foundation Foundation Digital Visions Susanne J. Leggett Employees Reed Smith LLP ALGOR, Incorporated Management Engineering Corporation Foundation Talbott Lea Simonds Foundation, Inc. Fuhrer Eagle Sales and Service Elizabeth Forward School District Relizon Marsh USA, Inc. BP Foundation, Inc. The Audrey Hillman Fisher Carl W. Herrmann, Inc. Furs Employees of Hamilton Buick Pontiac Foundation, Inc. Matthews, Bartlett & Dedecker, Inc. Brooks Family Foundation The Inns of Negley GMC and Hamilton Mazda Riggs Industries The Giant Eagle Foundation “If researchers can learn to prevent cancer, to control its McGuire Woods, LLP Buffalo Bills Alumni Foundation Inc. Tricia and Bill Kassling Ernst & Young LLP Romoff, Newman, Cesark & Daraio, LLC The Henry John Simonds progress, or to extend the lives of those with cancer for five, 10, McKinsey & Company, Incorporated Cancer Foundation for Kolman Jewelers Evans National Bank RP Sales, Inc. Foundation, Inc. even 20 years, that would be true success.” Corporation Melanoma Research LAGOS FEDEX Trade Networks RSM McGladrey, Incorporated The Henry L. Hillman Foundation Markos Tambakeras, chairman, president, and CEO, Corporation Members of the Steel City League Charles T. Campbell Charitable Burton Morris Fellow Workers of Henry Watson, IV S. M. Cristall Company, Inc. Foundation The Hillman Company Mercer Human Resource Consulting Dr. Susan Obagi Fleetboston Financial Corporation SAI Consulting Engineers CTRC Research Foundation The Juliet Lea Hillman Simonds Meyer Eckenrode Insurance Group Foundation, Inc. P&W Foreign Car, Inc., Forstmann San Diego Padres LP Elsa U. Pardee Foundation MINI of Pittsburgh Valerie and Peter J. Livaditis Allegheny County Chapter of Thrivent Michael Baker Corporation FRANCO Sanofi-Synthelabo Oncology, Inc. Rieder Photography Mary and Ronald E. Long Financial Lutherans/Family of Debbie Modell’s, Inc. Carlson G & G International Saperston Asset Management, Inc. Annie and Dick Rivers David E. Malehorn, PhD National City Bank Employees “Over the past 20 years, the most rewarding thing for us has American Academy of Otolaryngology Gateway Financial Group, Inc. Schnader Harrison Segal Lewis LLP RNCD Helen B. and Curtis R. Marquard National Council of Jewish Women been to watch the Cancer Centers’ growth and knowing that American Cancer Society, Incorporated GE Medical Systems Schneider Design Architects, PC University of Pittsburgh Jazz Combo Anne B. and William O. McConnel NBA Properties, Inc. it’s an integral part of the city of Pittsburgh.” General Motors Cancer Research Sigma Alpha Epsilon Fraternity University of Pittsburgh Kathleen McKowen American Coaster Co., Inc. Foundation New Era Cap Company, Inc. Annie and Richard Rivers Jr. Medical Center Society of Ladies Philoptochos Margaret and David J. McLeish American College of Surgeons Gerald Auto Group New York Yankees Bonnie and Tom VanKirk American Heart Association Sony Electronics Incorporated Carole Neiberg Grant Oliver Corporation Ogletree, Deakins, Nash, Smoak & American Institute for Stewart, PC Steel City Boogie Club The Lauri Strauss Leukemia Dana and Daniel A. Nestel Greater Pittsburgh Orthopaedic Emma Clyde Hodge Memorial Fund Cancer Research, Inc. The Performance Group, LLC Foundation Every gift plays a vital role in helping Gary V. Palmer Associates, Inc. Oncology Hematology Association American Society of Highway Engineers Entertainment Industry Foundation The Lilah Hilliard Fisher us achieve our mission of advancing Gunold USA, Incorporated Ortho Biotech Products, LP The Relizon Company Fred J. Pinkus Thomas M. Evans Foundation Foundation, Inc. research and enhancing patient care. American Textile Company Transportation Marketing Services Jothi and Rameshkumar Ramanathan, MD Hamilton Buick Pontiac GMC Company Unfortunately, space is too limited to Amgen Incorporated International, Inc. Fannie Mae Foundation The M & T Charitable Foundation P. J. Dick Incorporated list the individual names of donors that John Charles Regan Hat World, Inc The Pfizer Foundation, Inc. Aventis Pharmaceuticals, Incorporated Try-It Distributing Co., Inc. Frontier Science and Technology gave gifts at levels of $1 to $249. Please Jennifer A. and Marc W. Scales Hefren-Tillotson, Inc. Parker/Hunter Research Foundation, Inc. BAA Pittsburgh, Inc. United Parcel Service The Pittsburgh Foundation, from the know your support is truly appreciated. David L. Shindler Grant Channell Memorial Fund funds of: Barudan America, Inc. United Way of Allegheny County Louise and Archie Silver Howard Heinz Endowment The Edna G. and Larry Abelson and Baseball Office of the Commissioner University of Pittsburgh Winifred W. Slatery “You shouldn’t have to tell your children ‘There’s nothing more The Henry L. Hillman Foundation Barbara A. and M. Alfred Seltman, If we have made an error in any name Bond Schoeneck & King, PLLC University of Pittsburgh Medical Center DMD Medical Research Fund Jan D. Smith, MD we can do.’ We need to keep fighting for cures.” J and J Vazzalluzzo Foundation or omitted any name from this list, Bristol-Myers Squibb Company Magee-Womens Hospital of UPMC The Calihan Fund please accept our apologies and notify Lois T. and Ross H. Smith Jr. MD Ellen Goodman, Endowment donor J. Faye and Myles D. Sampson Buchanan Ingersoll, PC Varian Medical Systems Family Foundation us at 412-623-4700. Marguerite O. and The Honorable The Nancy T. and William S. Vedior North America William L. Standish III Cancer Research Institute James S. McDonnell Foundation Conover II Fund Victory Cap Front Mfg. Company, Inc. Maureen Sullivan Carr Textile Corporation Henderson Brothers Incorporated Parsons Brinckerhoff William V. and Catherine A. The Bill Few Memorial Fund Virgil Nipper Group McKinney Charitable Foundation, Mary and John Clark Unkovic CDM Hilb, Rogal & Hamilton Co. of Partners In Change, Inc. The Robert & Elizabeth Mertz Fund ChevronTexaco Corporation Pittsburgh, LLC Corporation The Jas H. Matthews and Co The Theresa L. Whiteside Nimick Egerton K. Van Den Berg PBS&J Educational and Charitable Trust Chicago White Sox The Hillman Company West Herr Automotive Group, Inc. Fund Janis and James I. Warren PC Solutions Joseph E. Lavine Foundation Chiron Corporation Hockey Western New York LLC Wheeler Brothers, Incorporated The PNC Foundation Pepsi-Cola Company Kennametal Foundation Citigroup Global Markets, Inc. Huttig Building Products William H. Prentice, Incorporated The Roesch Family Foundation Pfizer U. S. Pharmaceuticals Larry Potter Memorial Fund Cleyn Tinker International, Inc. IKM Incorporated (Pfizer Oncology) Xanthus Life Sciences, Incorporated The Russell Charitable Foundation Leukemia Research Foundation Clorox Company IKON Office Solutions

18 UPMC Cancer Centers University of Pittsburgh Cancer Institute 19 News Briefs

HEAD AND NECK SPORE GRANT LANCE ARMSTRONG BRINGS TOUR TM The University of Pittsburgh Cancer Institute received OF HOPE TO PITTSBURGH a five-year, $10 million Specialized Program of On Oct. 8, 2004, more than 2,000 cancer survivors, Research Excellence (SPORE) grant from the National their families, and friends converged upon PNC Cancer Institute to examine innovative treatment and Park, home of the Pittsburgh Pirates, to celebrate innovative risk assessment strategies designed to survivorship and the promise of clinical trials in improve survival outcomes for patients with head overcoming the burden of cancer. and neck cancer. This prestigious grant — the second SPORE awarded to UPCI — is one of only UPMC Cancer Centers partnered with the Oncology four in head and neck cancer awarded nationally. Nursing Society to bring the Tour of HopeTM to PROTEOMICS/GYNECOLOGIC Pittsburgh. This weeklong bike relay, featuring Lance Jennifer Grandis, MD, director of UPCI’s Head and CANCER GRANT Armstrong and a team of cancer survivors and care- Neck Cancer Program, will serve as the principal givers, crossed the country to raise awareness of investigator for the grant, which will fund four The University of Pittsburgh Cancer Institute is the importance of clinical trials. translational research projects focusing on genetic involved in two major cancer research collaborations changes that are potential risk factors for head and that are being funded by the U.S. Department of In Pittsburgh, local sports celebrities, as well as neck cancer, intracellular signaling proteins activat- Defense. leaders in the field of cancer research and care, ed during head and neck cancer, and new treatment shared the field with these inspirational heroes, who and vaccine strategies designed to reduce the mor- UPCI, Windber Research Institute, and the University shared their personal experiences with the disease. of Pittsburgh Schools of the Health Sciences were bidity and mortality from head and neck cancer. I awarded $3.4 million to create a program dedicated As the Tour crossed the country, people were to proteomics, which is the study of the shape, func- encouraged to make the Cancer Promise, a commit- tion, and expression of proteins. This promising ment to become better educated about cancer, to research may one day allow physicians to diagnose participate in prevention and early detection, and if cancer at its earliest stages by identifying specific faced with the disease, to contemplate participation proteins responsible for the disease, leading to bet- in clinical trials. ter prevention, screenings, and treatment. Ronald Herberman, MD, director of UPMC Cancer UPCI, Windber Research Institute, Walter Reed Army Centers and the University of Pittsburgh Cancer Medical Center, and Georgetown University received Institute, and executive director of the Pennsylvania $4.2 million to create a program to reduce the Cancer Control Consortium (PAC3), delivered incidence, morbidity, and mortality of gynecologic 20,018 Cancer Promises, signed by UPMC Cancer cancers. The initiative focuses on characterizing the Centers patients, staff, and others, to the Tour of HopeTM relay team during the Pittsburgh event. cancer molecular alterations associated with benign and I malignant gynecologic diseases and facilitating the DISCOVERY & CARE development of novel early detection, prevention, and treatment strategies. Cancer Discovery & Care is a publi- cation of the University of Pittsburgh U.S. Rep. John P. Murtha played a central role in MONTHLY SCREENINGS FOR Cancer Institute (UPCI) and UPMC AFRICAN AMERICANS obtaining the funding for both initiatives. I Cancer Centers and is produced by UPMC Corporate Communications. The African American Cancer Program of UPMC TM All rights reserved. No portion of this Cancer Centers and the University of Pittsburgh ADVANTAGE 4D magazine may be reproduced Cancer Institute was established to educate the Preliminary results at the University of Pittsburgh without written permission. Send African American community about the importance Medical Center demonstrate that a new imaging suggestions, comments, or address of early detection of cancer. African Americans have technology developed by GE Medical Systems changes to: Betsy Martinelli, UPCI/ a higher rate of cancer and suffer a disproportionate further limits the exposure of radiation to healthy UPMC Cancer Centers, Office of amount of cancer deaths. Through outreach programs tissue surrounding a tumor. Communications, UPMC Cancer such as community screenings, survivor self-help Pavilion, 5150 Centre Ave., Room 1c, Advantage 4DTM (Adv4D) is one of the first technolo- groups, and educational programs, the program is Pittsburgh, PA 15232, or e-mail to gies of its kind to allow physicists to perform helping to eliminate the barriers that prevent many [email protected]. African Americans from obtaining early cancer diag- respiratory gating — precisely following the move- nosis and treatment. ment of a tumor according to a patient’s breathing cycle. This, in turn, enables radiation oncologists to Screenings for breast, cervical, colorectal, oral, better target the radiation doses only at the tumor. ovarian, prostate, and melanoma cancers are held monthly at the Hillman Cancer Center in Shadyside, UPMC is one of only five centers in the nation as well as at the Alma Illery Medical Center in the evaluating Adv4D. I Homewood-Brushton section of Pittsburgh. I

20 UPMC Cancer Centers

NONPROFIT ORG U.S. POSTAGE cancer PAID PITTSBURGH, PA DISCOVERY & CARE PERMIT NO. 3834

A publication of UPMC Cancer Centers and the University of Pittsburgh Cancer Institute

UPMC Cancer Pavilion 5150 Centre Ave. Pittsburgh, PA 15232 1-800-533-UPMC (8762) www.upmccancercenters.com

UPMC Cancer Centers offers cancer patients exceptional care and innovative treatments close to home. Working in tandem with the University of Pittsburgh Cancer Institute, western Pennsylvania's only National Cancer Institute-designated Comprehensive Cancer Center, UPMC Cancer Centers provides the latest advances in cancer prevention, detection, diagnosis, and treatment at community- based locations throughout the region. The University of Pittsburgh Cancer Institute comprises the academic and research activ- ities for cancer at the University of Pittsburgh and the University of Pittsburgh Medical Center.

For information about supporting cancer research efforts and patient care at the University of Pittsburgh Cancer Institute and UPMC Cancer Centers, contact us at 412-623-4700.

UPMC Cancer Centers and University of Pittsburgh Cancer Institute