UPMC CancerCenter, partner with University of Pittsburgh Cancer Institute VOL 10, NO. 1, 2016 NO. 10, VOL

INSIDE 12 Making Medicine Personal | 16 The Determination to Make a Difference | 20 Young Mom Determined to Fight Cancer The University of Pittsburgh Cancer Institute, working in conjunction with UPMC CancerCenter, UPMC’s clinical care delivery network, is western Pennsylvania’s only National Cancer Institute (NCI)-designated Comprehensive Cancer Center, reflecting the highest level of recognition by the NCI. 4 12 16 20

UPMC CancerCenter and UPCI Executive Leadership ...... 2

Heroic Leadership ...... 3 A message from our Director and Chairman

30 YEARS OF INNOVATION ...... 4

How Hillman Cancer Center is Changing the Way Health Care is Delivered ...... 10

MAKING MEDICINE PERSONAL ...... 12

THE DETERMINATION TO MAKE A DIFFERENCE ...... 16

Celebrating Elsie Hillman and Her Legacy of Hope ...... 18

YOUNG MOM DETERMINED TO FIGHT CANCER AND HELP OTHERS ALONG THE WAY ...... 20.

A FUTURE WITHOUT CANCER ...... 23 2015 Hillman Cancer Center Gala

2015 DONORS ...... 24

Community Events ...... 31

News Briefs ...... 32

Cancer Discovery & Care is a publication of UPMC CancerCenter and the University of Pittsburgh Cancer Institute (UPCI) and is produced by UPMC Clinical Marketing. © Copyright 2016 UPMC. All rights reserved. No portion of this magazine may be reproduced without written permission. Send suggestions, comments, or address changes to Jessica Weidensall at UPCI/UPMC CancerCenter, Office of Communications, UPMC Cancer Pavilion, 5150 Centre Ave., Suite 1B, Pittsburgh, PA 15232, or via email at [email protected].

University of Pittsburgh Cancer Institute | 1 UPMC CancerCenter and University of Pittsburgh Cancer Institute (UPCI) Executive Leadership HEROIC LEADERSHIP

Nancy E. Davidson, MD Stephanie K. Dutton, MPA, CMPE Eric D. McIntosh Director, UPCI Chief Operating Officer Director, Human Resources, UPMC CancerCenter Vice President, UPMC CancerCenter Stanley M. Marks, MD Joel Nelson, MD Chairman, UPMC CancerCenter Peter G. Ellis, MD Chairman, Department of Urology Deputy Director, Clinical Services Charles E. Bogosta, MBA Susan Schoonover Associate Chief Medical Officer, UPMC CancerCenter Our thoughts naturally go to the many who set the vision and worked tirelessly President, UPMC CancerCenter Research Manager, Surgical Oncology Robert L. Ferris, MD, PhD, FACS people responsible for getting us here. alongside us in those early critical days. K. Scott Baker Chad J. Scott, MPH Associate Director, Translational Research, UPCI Vice President, UPMC Administrator, UPP Hematology-Oncology Not a single member of our extended His exceptional daring set the tone for Co-Leader, Cancer Immunology Program, UPCI Chief Government Relations Officer Shivendra V. Singh, PhD University of Pittsburgh Cancer Institute the innovations that followed. Michelle Fisher Reyes David Bartlett, MD Associate Director, Basic Research, UPCI Director, Advocacy and External Relations and UPMC CancerCenter family — Vice Chairman, Surgical Oncology and UPMC Cheryl Steele, RN, MSN, MPM, AOCN In this magazine, we highlight some of GI Surgical Services scientists, physicians, nurses, technicians, Director, Regulatory, Quality and Safety, Susan Gibson, RN, BSN, MBA the wonderful accomplishments we’ve Michael J. Becich, MD, PhD Medical Oncology support staff, donors — has ever been Senior Director, Hillman Cancer Center Associate Director, Cancer Informatics made over the past 30 years. We truly Scot Stevens content to go through the motions, to Jennifer Rubin Grandis, MD, FACS Richard P. Bondi Chief Information Officer do have much to celebrate. Leader, Head and Neck Cancer Program, UPCI settle for the status quo. Each possesses Chief Financial Officer Director, Personalized Medicine Technology, UPMC Lisa Haskins, RT (R)(T)(ARRT) a healthy restlessness, a desire to pursue Dana Bovbjerg, PhD Bennett Van Houten, PhD We also pay tribute to Elsie Hillman, a Senior Director, Radiation Oncology Leader, Biobehavioral Oncology Program, UPCI Co-Leader, Molecular and Cellular Cancer something more, something different, woman who gave so much and inspired Maureen Hatch, MBA Biology Program, UPCI Adam M. Brufsky, MD, PhD, FACP something great. Senior Director, Medical Oncology Operations so many. We all remain part of her Associate Chief, Division of Hematology-Oncology Jessica Weidensall growing legacy. And finally, we share Associate Director of Clinical Investigation, UPCI Dwight E. Heron, MD, FACRO, FACR Director, Marketing In our minds, you all are heroes. All Director, Radiation Services, UPMC CancerCenter Edward Chu, MD Elizabeth Wild, MBA exceptionally candid stories from donors Chairman, Department of Radiation Oncology, leaders. We observe your courage, Deputy Director, UPCI Senior Vice President, Global Oncology Services UPMC Shadyside Barbara Ventura and Barbara and Herb Chief, Division of Hematology-Oncology tenacity, and heart in the pursuit of our Jennifer C. Yates This year marks three decades Co-Leader, Experimental Therapeutics, UPCI Pawel Kalinski, MD, PhD Shear, as well as a courageous cancer Manager, Media Relations collective mission, every day. In our line Director of Research, Division of Surgical Deidre Cleary of our arduous yet increasingly survivor Kate Crawford. Oncology, UPCI Jian-Min Yuan, MD, PhD of work, failure is a given. But what we Senior Director, Clinical Research Administration Associate Director, Cancer Control and Population Michael Keyes promising pursuit to end cancer learn from failure and how we respond Frank Czura, CPA Sciences, UPCI We hope these stories help reinforce Executive Director Director, Compliance and Privacy, UPMC CancerCenter Co-Leader, Cancer Epidemiology and Prevention Program — or, at minimum, reduce its can and will save lives. Knowing this The Regional Cancer Center your resolve in our noble cause. Maryann Donovan, PhD, MPH Karen Yuhas, RN, BSN, MBA keeps us moving toward our goal. James D. Luketich, MD heavy burden. Associate Director, Research Administration, UPCI Director, Central Billing Office We remain guided by our resolve to Co-Director, Surgical Oncology Services Chairman, Department of Cardiothoracic Surgery Leading the charge and setting an create a better future. inspired example, was our first and most heroic leader Ronald Herberman, MD,

University of Pittsburgh Cancer Institute (UPCI) Council

Chair Nick DeIuliis William Isler The Honorable John R. Pippy Sy Holzer Joseph W. DeNardo William Kassling Jane Roesch Nancy E. Davidson, MD Stanley M. Marks, MD Robert Denove Mario Lemieux Cynthia Roth Vice-Chair Douglas P. Dick Sally Levin* Susan C. Santa-Cruz Elsie H. Hillman* George A. Fechter Jeffrey Lipton Frederic B. Sargent Curtis Aiken Sr. Lee B. Foster II David Malone Dan Shapira Thomas Balestrieri John P. Friel Kevin McClatchy Robert Slagle* G. Nicholas Beckwith III Chip Ganassi Susan P. McGalla Sandy Snyder Director Chairman James Broadhurst Thomas B. Grealish Katie McSorley Thomas VanKirk University of Pittsburgh Cancer Institute UPMC CancerCenter Carlos Cardoso Joseph Haleski Leslie Merrill The Honorable Jack Wagner Frank Coonelly Roy W. Haley David Morehouse John Weinstein Harriet Crawford I.N. Rendall Harper Eugene J. O’Sullivan Michael Zamagias Randall L. Crawford Mark Hart Arnold Palmer Barbara Crown Dawne Hickton Bradley Penrod

*Deceased

2 | UPMC CancerCenter University of Pittsburgh Cancer Institute | 3 On September 3, the University of Pittsburgh Cancer Institute (UPCI) proudly celebrated the first 30 years of an ambitious collaboration between UPMC, the University of Pittsburgh, and Carnegie Mellon University to contest the ubiquity of cancer and lessen its toll.

It all started in a linen closet … or perhaps in a trailer ... or a converted patient room …. Everyone tells a slightly different tale. But this is certain: since its undeniably humble beginnings in the Oakland section of Pittsburgh, UPCI now includes more than 2,000 physicians, researchers, and staff focused on the complex, seemingly relentless disease. These individuals are leading approximately 440 active clinical trials to improve cancer care. And each year, they are part of a team that cares for some 70,000 patients and publishes as many as 1,000 scholarly articles about their transformative work.

The staff takes tremendous pride in this. Dorothy Mann, manager, Division of Hematology/Oncology and UPCI’s fifth employee, recalls the early days, with people being “peppered all over” with “no cell phones, no fax, no email” and just doing “a lot of running” from makeshift lab to makeshift lab. A cancer survivor herself, Mann is reassured by the progress she sees firsthand. “I am in awe of the researchers,” she says. “They are so committed and they will not give up until they find a cure.”

HILLMAN CANCER CENTER

4 | UPMC CancerCenter University of Pittsburgh Cancer Institute | 5 UPMC experienced rapid growth and transition during the early 1990s. Then in 1997, Shadyside Hospital merged with UPMC, and UPCI was moved to Shadyside. In 1990, the National Cancer Institute designated UPCI as a Comprehensive Cancer Center, a distinction currently held by only 45 centers throughout the country. The elite designation was renewed in August of 2015.

In 2000, Stanley M. Marks, MD, and his oncology and hematology group joined UPCI, which led to significant expansion of medical and radiation oncology clinical activities. And in 2002, Hillman Cancer Center opened on the UPMC Shadyside campus, bringing the research and clinical aspects of UPCI and UPMC CancerCenter together under one roof. It provided the nucleus for an integrated community network of cancer physicians and specialists throughout the region, as well as in strategic locations around the globe. (See separate story on Hillman Cancer Center on page 10.)

“We’ve made some great discoveries here,” says Nancy Davidson, MD, “Considerable work is being done in the area of radio protection “There are so many different directions we can take in trying to undo director of UPCI. “And that translates to improved patient outcomes.” and radio sensitization,” adds Dr. Davidson. “We’re exploring how this awful stuff that tumors do,” says Dr. Whiteside. “When I started we can maximize the therapeutic index so we get lots of good working with dendritic cell-based vaccines many years ago, people The American Cancer Society reports 1.5 million deaths from cancer effects, and fewer bad effects.” didn’t want to buy this idea that tumors are immunoinhibitory. Now have been prevented in the U.S. since 1991 “when UPCI was coming this has become a very hot topic of investigation. For many years, UPCI’s radiation oncology team has been working in this area for into its stride,” according to Dr. Davidson. Deaths are continuing to there was chemotherapy, surgery, and radiation therapy, and that more than a decade, she says. decrease about one percent per year, she noted. “I think it’s our job was it. Now, finally, people recognize the power of the immune to use all the amazing scientific understanding that we’re gaining to A current project is being overseen by the University of Pittsburgh’s system. Now, people are thinking of combinations of immunotherapy make that statistic even stronger.” Center for Medical Countermeasures Against Radiation, which is with conventional surgery, with conventional radiation therapy, and dedicated to identifying and developing small molecule radiation with conventional chemotherapy. Discoveries Bring Hope protectors and mitigators that easily can be accessed and administered “We are without question one of the finest cancer centers in the world,” “There is a rainbow, I think, on the horizon,” says Dr. Whiteside. “It’s in the event of a large-scale radiological or nuclear emergency. The team says Dr. Marks, current chairman of UPMC CancerCenter. “We have so multidisciplinary, translational research and condensed application found that resveratrol, a natural antioxidant commonly found in red many thought leaders in the areas of immunology, immunotherapy, of all different approaches that leads to success. If you are with other wine and many plants, may offer protection against radiation exposure. DNA, viruses, drug development, and drug discovery. Our Phase I people who bring different expertise to the game, then the game program (first in human trials) is one of the best in the country. But the primary focus at UPCI has been on medical oncology, becomes more interesting and moves more rapidly.” according to Dr. Marks. “Cancer treatment is a three-pronged approach: surgery, medical The work of Dr. Kirkwood and his team also has been game- “WHEN WE BEGAN THIS oncology, and radiation therapy,” he says. “We’re making huge UPCI has long been a leader in tumor immunology research, he changing. He has been enormously successful in securing support WORK, THE AVERAGE advances across the board.” says. “Most now agree that immunotherapy is where the future of for the development of numerous innovative immunotherapies, cancer treatment lies, but UPCI has held this belief for decades.” particularly for melanoma. From a surgical standpoint, UPMC CancerCenter is at the forefront SURVIVAL OF A PATIENT Not surprising when you consider the NK or natural killer cell was of new technologies and innovative therapies, with expertise in “The body’s own immune system has the ability to recognize WITH METASTATIC identified in the laboratory of UPCI’s founding director Ronald B. liver resections, HIPEC (heated intraperitoneal chemoperfusion and lash out against disease,” he says. “In 1986, we had no Herberman, MD, when he was with the National Institutes of Health. MELANOMA WAS used to treat abdominal cancers), and many new minimally treatments that altered survival of melanoma. Now there are MEASURED IN A FEW invasive surgeries. Dr. Marks adds that two of UPCI’s earliest staff members — Theresa 10 FDA-approved treatments for metastatic melanoma and three Whiteside, PhD, professor of Pathology and Immunology at the for adjuvant therapy. Even five years ago, we didn’t have any MONTHS; NOW THE “As for radiation, we have the largest CyberKnife® program in the University of Pittsburgh School of Medicine, and John Kirkwood, MD, therapies for advanced melanoma; now we have six. country,” Dr. Marks says. “We also have a training center designed AVERAGE SURVIVAL IS director, Melanoma and Skin Cancer Program, UPMC CancerCenter Progress has been explosive.” to teach physicians from around the globe about new technologies TWO YEARS.” — are recognized around the globe for their work in immunology. JOHN KIRKWOOD, MD in radiation therapy.”

6 | UPMC CancerCenter University of Pittsburgh Cancer Institute | 7 Early in his tenure at UPCI, Dr. Kirkwood led a multidisciplinary team Another lauded achievement at UPCI was the identification of “In the past, it was one size fits comprised of 22 academic institutions and more than 300 community Kaposi’s sarcoma and Merkel cell cancer viruses, two of the seven all and not everyone responded “CANCER’S JUST TOO hospitals that established interferon alpha as the first effective viruses that cause cancer. These discoveries are due to the work to therapies because every adjuvant therapy for high-risk melanoma patients. Without this drug and leadership of Patrick Moore, MD, and Dr. Yuan Chang, MD, tumor is different,” she says. SMART. WE NEED therapy, which is given after surgery, patients would have a one and who were just renamed as American Cancer Society professors, “In the future, I think we’ll have INNOVATIVE DISCOVERIES one-half times greater chance of relapse and death. “a very elite group in our country,” according to Dr. Davidson. a better understanding of genetics and be able to better tailor Dr. Chang also was named to the National Cancer Advisory Board treatment plans.” TO ATTACK IN MULTIPLE Dr. Kirkwood also is involved in trials using new agents in by President Barack Obama. WAYS, FROM neoadjuvant therapy. In neoadjuvant therapy, treatment is given to Investigators seem to agree there is a strong movement toward DIFFERENT ANGLES.” shrink a tumor as a first step, prior to the primary treatment, which “Twenty percent of cancers around the world are caused by viruses and personalized medicine. Big data and bioinformatics also will be very typically is surgery, but also may be radiation or hormone therapy. other infectious agents so the fact that we have these brilliant important, according to Dr. Davidson. “We’re going to be able to DAVID BARTLETT, MD investigators here, leading one of the strongest cancer virology do all this sophisticated cancer sequencing and molecular testing,” “If there’s a lymph node, you’re dealing with Stage III melanoma,” initiatives in the country, is significant,” says Dr. Davidson. “Big cancers she says, “so we’re going to need to have equally sophisticated he explains, “so rather than operate and wait to treat, we do a biopsy, that have viral causes are Hepatitis B, liver cancer, and the HPV virus, bioinformatics solutions to apply this information.” which takes five minutes, and then start treating before surgery. which causes cervical cancer and head and neck cancer,” she explains. “Clearly, we have a long way to go to better treatments and cures,” “When we began this work, the average survival of a patient with Dr. Chang and Dr. Moore are especially interested in the problem of says Dr. Marks. “The road to getting there is going to require new metastatic melanoma was measured in a few months; now the patients who are in an immunosuppressed state after a bone marrow ideas — whether it’s new technology, immunotherapy, or better, average survival is over two years,” says Dr. Kirkwood. “We expect or organ transplant; these people are more vulnerable to cancer. safer treatments for cancer. One thing is for certain, though, we’re it soon will be possible to cure a fraction of patients with inoperable “Cancer’s just too smart,” suggests David Bartlett, MD, vice chairman, going to be curing a lot more people than we are today.” distant metastatic melanoma.” Surgical Oncology and Gastrointestinal Services, UPMC CancerCenter, These immunotherapies developed for melanoma have shown and professor of clinical and translational science, UPCI. “We need The Wind Beneath Our Wings to also work in lung, head and neck, and bladder cancers. innovative discoveries to attack in multiple ways, from different angles. “We’ve come a long, long way in 30 years,” says Dr. Davidson. “And we owe a debt of gratitude to a lot of people.” She points “Our whole approach to vaccine development for melanoma “I personally think the most exciting advances in therapy have been specifically to the leadership of Thomas P. Detre, MD, PhD, late recently led to approval of the first vaccine for prostate cancer,” along the immune front,” says Dr. Bartlett. “We are looking to vice chancellor of UPMC, and Dr. Herberman. Also critical to early says Dr. Kirkwood. “Immune therapies will clearly have an develop many new viruses that will enhance immune potential of success, Dr. Davidson says, were the investments made by the application in many cancers, maybe even leukemia,” he says. treatment. It’s an exciting time for this research.” (Dr. Bartlett’s Commonwealth of Pennsylvania, the Richard King Mellon vaccine work is discussed on page 10 in the story about Hillman Foundation, the Benedum Foundation, the Shadyside Hospital “The biggest challenge we have is dealing with cancer in its Cancer Center.) Foundation, the Hillman foundations, and others. earliest stages so that’s been our focus the last two years,” notes Dr. Kirkwood. Among other initiatives, he and his team created an “I always thought of cancer as a very interesting and difficult puzzle,” Regrettably, cancer still is the second leading cause of death. outreach program designed for primary care physicians to help them Dr. Bartlett says. “It can wear on you when patients lose their battle; make early diagnoses of cancer; pilot data suggests doing so may it’s like losing a friend. But the element of discovery is exciting. And “You’d be hard pressed to find someone who hasn’t been touched reduce the burden of cancer by half. it’s rewarding for me to provide new options and new hope for these by it,” contends Dr. Bernstein. “I just think, with the government patients that have exhausted all the standard therapies. cutbacks, there’s never been a more important time to make a Dr. Kirkwood was awarded a SPORE (National Cancer Institute’s commitment to research,” she says. “Even a small amount of funding competitive Specialized Program of Research Excellence) grant “A lot of people I treat have already metastasized and their backs really helps. I can’t think of a better way to honor someone who was seven years ago to do this important work. The award was renewed are up against the wall. It’s a very unique time to be involved in important to you.” in November 2013. The SPORE grant requires cancer institutes to someone’s life. They appreciate any approach you can offer them foster strong collaboration between eminent scientists and clinicians that extends their life or enhances the quality of their life. I think “Our hands would be tied without our donors,” agrees Dr. as well as outstanding programs in translational research. that’s what keeps us going.” Davidson. “The work we do is possible only because of our donors’ commitment to help us win the battle. They are every bit our There are only about 50 SPORE grants awarded in this country at The Next 30 Years? comrades in arms.” any one time, and UPCI has the distinction of having four of them for “My personal hope is that cancer won’t be a death sentence for several years, notes Dr. Davidson. The other three support people,” says Kara Bernstein, PhD, one of UPCI’s newest researchers. investigators working with head and neck, lung, and ovarian cancers. “I hope we reach a cure or that we at least can manage cancer like we do diabetes. I hope to be out of business.

8 | UPMC CancerCenter University of Pittsburgh Cancer Institute | 9 HOW HILLMAN CANCER CENTER IS CHANGING THE WAY HEALTH CARE IS DELIVERED

The October 2002 opening of Hillman Cancer Center was the realization of a shared vision of Henry and Elsie Hillman and the University of Pittsburgh Cancer Institute’s (UPCI) founding director Ronald B. Herberman, MD.

“There is constant back and forth translation absolutely pioneering work, and we’re and forward momentum here that we’ve seeing immediate patient outcomes. not experienced before,” Dr. Davidson says. Patients come for the procedure from “It’s exceeding our expectations.” all over the country.”

UPCI’s clinical trials in dendritic cell Another feature of Hillman Cancer Center therapy (a new and quickly evolving form is that it serves as the flagship facility for of immune therapy) are a case in point, UPMC CancerCenter’s network of more explains David Bartlett, MD, vice chairman, than 40 sites in western Pennsylvania and Surgical Oncology and Gastrointestinal internationally, including Italy and Ireland. Services, UPMC CancerCenter, and “They are the three foundational pillars professor of clinical and translational “We created a hub and spoke model so Supporting the model is Via Oncology myeloma, and other blood malignancies. for this truly distinct and comprehensive science, UPCI: patients wouldn’t have to leave their Pathways, a disease-specific, evidence- Patients who normally have to travel to hematology and oncology center — community hospital setting to obtain based cancer treatment protocol developed different offices to visit various clinicians distinct in that it links laboratory science “In this instance, we are performing world-class care,” says Stanley Marks, by UPMC. Pathways is a suite of Web-based and undergo testing instead are able to and clinical care under one roof,” says surgeries on patients with metastatic MD, chairman, UPMC CancerCenter. decision-support tools physicians use to see their entire care team in one place. Nancy E. Davidson, MD, director of UPCI. colon cancer at UPMC Shadyside and “We believe patients should have access guide them in developing a treatment plan “We see more than 200 new patients “Ron Herberman and the Hillmans then carrying the cancer next door to the to the best available care, close to home. customized for each patient’s particular type with acute leukemia each year, and provided the leadership, inspiration, and laboratory at the Hillman Cancer Center and stage of cancer. Each Pathway combines “It doesn’t matter which facility a patient are conducting several clinical trials firepower to get us to this place and we where each tumor is digested into a innovative and promising clinical trial options chooses; they will be treated well and for these patients,” says Dr. Marks. “But always will be indebted to them.” single cell suspension and prepared for with the best standard-of-care therapies. a custom vaccine. After surgery, the consistently,” Dr. Marks notes. “Doctors we also perform about 200 stem cell But Dr. Davidson credits the growing patients are seen in the clinic portion of are all on the same team and regularly “Pathways covers 95 percent of cancers. transplants per year and have a team of number of achievements of Hillman the Hillman Cancer Center. There, the communicate. It’s a cohesive, transparent, The algorithms have been so successful eight full-time leukemia physicians and Cancer Center to the UPCI and UPMC and efficient model.” that they’re now being used by 1,200 staff to manage the transplants. patient’s blood is filtered and dendritic Further, the Hillman Cancer Center faculty CancerCenter staffs. providers in 20 states,” Dr. Marks notes. cells removed. The dendritic cells are “So, yes, we are conducting illuminating and physicians are actively involved in carried back to the lab and combined “Still, patients always are welcome to “We all are very passionate about bringing research and performing world-class community outreach and education to with the previously removed cancer cells visit Hillman for a consultation or second scientific discovery to state-of-the-art clinical trials that will affect cancer care ensure the latest advances in cancer to create a potent dendritic cell vaccine. opinion. And often, the most rare and cancer care. The concept of taking our in the future, but we’re also employing research and treatment are shared and After the supercharged dendritic cells are complex cases are handled here due to discoveries from the bench to the bedside, state-of-the-art treatments that are understood throughout western given back to the patients, we carefully the disease specialists based here.” and then out to the broader community, improving and prolonging lives, right now.” Pennsylvania and beyond. track each patient’s progress — wherever is very exciting.” The Mario Lemieux Center for Blood they are. Cancers in Hillman Cancer Center provides The physical space — with the laboratories “Having the hospital operating rooms, an example of the disease-specific care on one side and the clinical operations on the the clinical patient experience, and the available to patients. It offers other — was designed to spur meaningful, laboratory physically adjacent to each comprehensive diagnostic services, real-time dialogue and interaction among “WE ALL ARE VERY PASSIONATE other allows us to offer this approach,” individually designed treatment plans, scientists, medical oncologists, surgeons, Dr. Bartlett says. “The technology behind and long-term follow-up services to ABOUT BRINGING SCIENTIFIC and other medical staff. this dendritic cell therapy was developed patients with leukemia, Hodgkin’s and DISCOVERY TO STATE-OF-THE-ART here by Pawel Kalinski, MD, PhD; it’s non-Hodgkin’s lymphoma, multiple NANCY E. DAVIDSON, MD CANCER CARE.”

10 | UPMC CancerCenter University of Pittsburgh Cancer Institute | 11 HERB AND BARBARA SHEAR MAKING MEDICINE PERSONAL A Family’s Gift Advances Genomics Research

Herb and Barbara Shear created the “We both are interested in and encouraged by the advances we’ve seen in medicine and particularly the progress being made Shear Family Foundation with their in cancer research,” says Barbara Shear. “We want to help continue children in August of 2014 as a means to this impressive momentum.” fund — and propel — a set of nonprofit To that end, the Shears recently made a significant gift and pledged multi-year support to the University of Pittsburgh Cancer Institute organizations and causes whose missions (UPCI), partner with UPMC CancerCenter.

align with their own. They also see their “There are brilliant, dedicated researchers at UPCI doing foundation as an opportunity to teach transformative, life-saving work,” says Herb. “This is the type of project the Shear Foundation wants to get behind.” their grandchildren about the joys and “The Shears are helping us to advance our program in precision responsibilities of philanthropy. medicine, especially in the area of breast and ovarian cancers,” says Nancy Davidson, MD, director of UPCI. “The funds they’re “We’re still early in the game,” says Herb Shear, “but we’re making providing will allow for the sophisticated infrastructure needs some heart-felt and strategic decisions that we think will have such as tissue banking, data bases, and analytics needed to support long-term impact. That’s what gets us excited. We want to help the initiative. make a measurable difference in areas we really care about.” More specifically, the investment will support investigation in Herb is chairman and CEO of the Shear Family Office, which genomics of breast cancer, as well as research projects ranging from manages the Shear Family Foundation and Shear Family Investments. work on a specific subtype of breast cancer called lobular cancer Formerly, he was the executive chairman and CEO of GENCO, where to a comprehensive genomic characterization of breast cancer he earned an international reputation for pioneering work in reverse metastases, to understand the molecular pathways that contribute logistics. He grew the family business into the second largest to this advanced and generally lethal stage of the disease.” third-party logistics provider in North America, and then sold the company to FedEx in 2014, which enabled the Shears to focus on “The work supported by the Shears is focused on translational other passions. research — research that extends from the laboratory bench into the communities we serve,” explains Dr. Davidson. “UPMC The Shear Foundation’s focus areas include medical research, CancerCenter is optimized for and excels in this type of research.” hunger insecurity, Jewish causes, and family issues.

12 | UPMC CancerCenter University of Pittsburgh Cancer Institute | 13 MAKING MEDICINE PERSONAL

Barbara recalls when a young scholarship recipient landed his first job and told the Shears that they had inspired him so much by their support of the program that he donated $500 of his own to the school.

“We’re really, really proud of our kids because they have participated in some amazing philanthropic initiatives, but this was outside the family and special to us,” she recounts. “Herbie and I grew up knowing that it was important to give back; it’s just what we did,” Barbara says. “We feel very lucky to have this opportunity and to be sharing it with our family.”

Barbara and Herb Shear have set a high bar. Both are active in American Israel Public Affairs Committee and are past board members of Leket, Israel’s National Food Bank. Herb also is past president of Greater Pittsburgh Community Food Bank and former board member of University of Pittsburgh. Barbara is involved in a volunteer leadership capacity at Israeli Food Bank, the University of Pittsburgh, the Hebrew Union College-Jewish Institute of Religion, and the Jewish National Foundation in Southern Florida.

While the Shears prefer to maintain a low profile, they agreed to be featured here with a little prodding.

“If it will help spread the word about this new and exciting research in personalized medicine and gene sequencing and if it inspires other people to contribute in ways that they can,” says Barbara, “then it’s the right thing to do.”

UPCI, of course, is enormously grateful to the Shears for their investment.

The work will be led by Adrian V. Lee, PhD, director of the “The scientific opportunities have never been better and we Women’s Cancer Research Center, a collaboration between UPCI appreciate the Shears’ commitment to support our UPCI “THERE ARE BRILLIANT, and Magee-Womens Research Institute. investigators in their quest to develop high impact ideas that can DEDICATED RESEARCHERS lead to advances in our ability to practice molecular cancer “The more we heard the more we wanted to be active and make AT UPCI DOING medicine,” says Dr. Davidson. “Their partnership and confidence in a commitment there,” Barbara says. “We just think they’re on the our work are extraordinary gifts to our research team and ultimately TRANSFORMATIVE, cutting edge in a lot of areas.” to our patients.” LIFE-SAVING WORK.” The family time and the educational components of their endeavors HERB SHEAR are important to the Shears, too.

“We find it gratifying to embark on this endeavor with our two sons and daughters-in-law, and instill in them and their children a spirit of generosity and empathy,” she adds. “One thing we have planned is to have the grandkids think about where they want to make a donation and why.”

14 | UPMC CancerCenter University of Pittsburgh Cancer Institute | 15 BARBARA VENTURA

THE DETERMINATION TO MAKE A DIFFERENCE There’s a lot to appreciate about Barbara Ventura. One of those things is her abounding delight in being the youngest of eight children.

“No matter how old I was, I was always referred to as the baby sister. “When Barb contacted our office, she knew she wanted to direct her Yep all the time.” And nothing could please her more. “It was nice giving toward cancer research to essentially become part of the growing up in a big family. I feel very fortunate.” cure,” Ilene recalls. “We arranged a tour of Hillman Cancer Center and a meeting with Dr. Davidson, answered her questions and just Barb is the kind of sister — and the kind of nurse — we all would like helped her with some of the technical details of making her gift.” to have. Compassionate, devoted, optimistic, generous, and always up for some fun. Barb was determined to make a difference in the fight against cancer.

She beams when she speaks of her siblings and the natural caregiving “People said, ‘Barb, are you sure you want to do this?’ I never role she often assumes with them. Five of the eight suffered from some batted an eye. It was an easy thing to do. It’s the only way they’re going type of cancer. Mary, her oldest sister had melanoma. Ann died from to make any progress with this terrible disease. If there was something cholangiocarcinoma that spread to her spleen, liver, and gallbladder. I could do to encourage more people to give, I would do it.”

“We thought Ann had the flu at first,” remembers Barb. “She was This spirit of generosity seems to run in the family. admitted on New Year’s Eve and died on February 9. But she got very good care.” “I do think we’re a giving family even though we’re not wealthy,” Barb says. “My parents (her father a shoemaker and her mother a Barb’s brother Bob had cancer of the kidney and prostate, and had homemaker) always emphasized going to school and doing what basal cell carcinoma on his ear, Barb says. “He’s still living; he’ll be we were supposed to do. And you better be home for dinner. 91 in December.” It was nothing like this one at four and this one at six; none of that business. We always made it home on time. And you ate Gene had lung cancer and died at 60. And another sister, Eleanor, what Mamma fixed. We had good family values instilled in us. 87, has colon cancer. “My one brother with the kidney and prostate cancer put four kids “Eleanor is doing well with chemotherapy. This hasn’t slowed her through Duquesne University and after they graduated, he continued down a bit.” to make donations to Duquesne for scholarships. And another brother of mine gave money every month to St. Jude Children’s These experiences have created considerable heartache for the Hospital. His wife had lymphoma. My sister who has cancer now family, but they also strengthened Barb’s resolve to fight for a cure. gives to UPMC CancerCenter.” “Cancer has just always been in my mind because it’s been a Barb has directed her money to lung and gastrointestinal cancer big factor in my family,” Barb says. “When I pass on, University of research, and also makes donations to UPMC CancerCenter Medical Pittsburgh Cancer Institute will get a little bit of money through my Oncology, Uniontown, in honor of Sajid Peracha, MD. annuity. I just think giving what little I’m able to give will further cancer research, and that’s what I want to do.”

Ilene Tobias, assistant director of planned giving, Medical and Health Sciences Foundation, helped Barb understand precisely what her gift to UPCI could do.

16 | UPMC CancerCenter University of Pittsburgh Cancer Institute | 17 THE DETERMINATION TO MAKE A DIFFERENCE CELEBRATING ELSIE HILLMAN ELSIE HILLMAN AND “My sister and I both give in honor of Dr. Peracha,” Barb says. HER LEGACY OF HOPE “I just love him. And lung and gastrointestinal are dear to my heart right now because of my family history.” She notes, “big strides” have been made since her brother died of lung cancer in 1992. Esteemed philanthropist Elsie Hillman was a “Elsie wasn’t one to hand over a check and say ‘build it‘,” says “I have a friend with lung cancer and he can get out and do things. Stanley M. Marks, MD, chairman, UPMC CancerCenter and chief woman of vision and action, devoting her life My brother didn’t have that opportunity,” she says. “And of course, medical officer, UPCI. “She was directly involved in the planning my sister is doing very well. I hope that continues.” to community service from a very young age. and design of the Hillman, even to the point of choosing furniture, We can only hope her optimism and good old fashioned neighborly Her voluminous legacy includes important wall colors and artwork,” he recalls. “She got down to details, and kindness are contagious. she never missed a meeting of the patient care committee unless advances in cancer discovery and care with she was traveling.” “Barb is such a warm and wonderful person,” says Ilene. “She’s been long-term implications. She died on August 4 a real inspiration to me, personally. I mean, her family endured so A founding member and vice chair of the UPCI Council, Mrs. much tragedy. But she credits Dr. Peracha and UPMC with saving at the age of 89. Hillman reportedly shared every comment she received about her sister’s life. And she is turning her gratitude into a gift that will the cancer center, good or bad, and expected every issue to be While the Pittsburgh native was a widely known and effective benefit cancer research and other people.” immediately researched and resolved. catalyst within the highest levels of U.S. politics, we knew her Barb graduated from St. John Hospital School of Nursing in 1958 best for her tireless work to lessen the burden of cancer. “No one was more committed to cancer patients,” says Dr. Marks. and then worked as a nurse for 47 years. She began as a general duty “Cancer is never fun, but it was important to her that we make the Through the Hillman Foundation, Elsie and her husband Henry staff nurse at Uniontown Hospital and then spent the majority of her experience as pleasant as possible for patients and families. She career working for a general surgeon, who also ultimately died from donated many millions of dollars to support research and cancer was enormously passionate and effective in doing that, but also cancer. She then completed two stints as an industrial nurse. At care at UPCI and the UPMC CancerCenter, specifically playing as down to earth as could be.” Rockwell International, she was the sole medical professional on site a crucial leadership role in the conception, design and building for 950 employees. The last 12+ years of her career were spent as a of Hillman Cancer Center. David L. Bartlett, MD, vice chairman, Surgical Oncology and school nurse in the California Area School District in Pennsylvania. Gastrointestinal Services, says the loss of Mrs. Hillman is “In addition to being pivotal donors for the cancer center, “I’ve been very blessed,” Barb insists. “I had really good jobs all the tremendous for the UPCI/UPMC family, that “it was her personal the Hillmans supported almost 100 researchers over the past time. I’ve learned so much and enjoyed them all.” touch that really developed the culture at Hillman Cancer Center.” 10 years through their foundations and scholar programs,” A member of St. Theresa’s church in Uniontown, Barb sings in the says Nancy E. Davidson, MD, director of UPCI. A wife and mother of four, with nine grandchildren and 14 funeral choir, is a member of the wake service, and belongs to the great-grandchildren, Mrs. Hillman valued family above all else, The couple was instrumental in the development of the altar society. Dr. Davidson acknowledged. Shadyside Hospital Foundation, Magee-Womens Research “I’m busy. I’m on the go all the time,” she says. Upon retirement, Institute, and Children’s Hospital of Pittsburgh of UPMC. “But she also was a treasured member of our UPMC family,” Barb joined the local YMCA. The Hillman Foundation also underwrote the construction of Dr. Davidson suggests. “She will be missed. But she leaves us in a the Herberman Conference Center on the Shadyside campus, far better place and her influence is around us every single day.” “Believe me, that’s been wonderful,” she shares. “I made some nice and endowed the Hillman Professorship of Oncology. friends at water aerobics, and we do a lot of things together. In addition to her philanthropic work with UPCI and UPMC “My friends went to Germany,” she recalls. “‘Oh come on, Barb,’ they “Elsie cared deeply about our providing exceptional patient CancerCenter, Mrs. Hillman generously supported the Pittsburgh said. But I had no desire. I’ve been to Florida. I’ve been to Las Vegas. experience and outcomes,” says Dr. Davidson. “She advocated Symphony Orchestra, WQED, the Hill House Association, and I’ve been to Boston. I’ve been to San Francisco. I haven’t gone zealously for the best possible science, the best possible other local causes. Her interests and philanthropy also took her anywhere lately,” she says, “because I don’t want to leave Eleanor.” treatments and staff, even the best possible surroundings. to a national stage where she worked to influence civil rights, Until the day she died, she remained extremely engaged in champion women’s causes, and increase jobs. She served 20 That’s a baby sister for you. Well, that’s Barb for you, anyway. the patient experience.” years on the Republican National Committee and is credited with helping to elect President George H. W. Bush, Senator John Heinz, To learn more about how you can include UPCI or UPMC and Pennsylvania governors Dick Thornburgh and Tom Ridge. CancerCenter in your will or trust, contact Lisa Sciullo, According to The New York Times, Mr. Bush, upon learning of her director of Planned Giving, at 412-647-0515 or [email protected]. death, referred to her as “one of the brightest points of light and A charitable bequest allows you to support specific programs or initiatives of meaning to you, while maintaining your desired cash finest political activists in the country.” flow during your lifetime. It also can help you reduce estate taxes.

18 | UPMC CancerCenter University of Pittsburgh Cancer Institute | 19 KATE CRAWFORD YOUNG MOM DETERMINED TO FIGHT CANCER AND HELP OTHERS ALONG THE WAY Kate Crawford likes to keep it real. Skip the hyperbole. Cancer sucks.

It’s important to the 31-year-old wife, mom, and fire-fighter-turned- She wrote in her blog about accepting the reality of paper plates entrepreneur that people hear this. Loud and clear. Because if we and a messy house. China plates and cloth napkins seem far less don’t acknowledge how complex, widespread, and life-changing important now. cancer is, Kate maintains, we aren’t likely to win the fight against it. “Another thing I like to tell everyone, especially women under 40, is to “I want to show the rawness and reality of breast cancer, not perform breast exams on yourself and trust your instincts,” she adds. sugarcoat it and say everything is OK,” Kate says. “I want people to “You have to be your own advocate. I found the lump on my breast, know what’s going on and what I’m feeling.” and I’m the one who called the doctor to find out what was happening.”

Kate was diagnosed with stage IV breast cancer at age 29. Her son It was in August of 2012 that Kate noticed her right breast had Stephen, who was born premature and continues to require intensive become hard. therapy, was just 3 years old. The twins, Grace and Lily, were 5. Kate’s daughter Shannon had died six years earlier at three days old. “There wasn’t a lump; the breast tissue just became more dense,” On the heels of losing her first child, Kate again endured a tough she explains. “The only reason I even felt my breast was because pregnancy and lost a second child. All this, and Kate’s husband, I had a friend in Australia who was diagnosed with breast cancer Steve, had just become a police officer, which came with its own at age 40. She told us one in eight women is diagnosed with breast demands and worries. Also, the successful nonprofit Kate founded in cancer so she knew one of her friends would get diagnosed with it Shannon’s memory required enormous time and energy. The weight during her lifetime. I never even thought about it before that.” of it all could have easily crushed Kate and her young family. Kate noticed other symptoms, too. “I started experiencing pretty But through her faith, Kate found courage and continues each day to horrific back pain, and I developed a cough and fever.” This prompted persevere, appreciating that her family loves and depends on her, her to make a doctor’s appointment. and recognizing there is a lot she still wants to accomplish in her life. After a series of mammograms and ultrasounds, Kate was told As a sort of therapy for herself and also a way to help others coping she had breast cancer. Soon after that, a scan showed the breast with cancer, Kate talks openly about her diagnosis, treatment, cancer had metastasized to both breasts, her lymph nodes, right experiences, letdowns, small wins, and myriad emotions. shoulder, ribs, spine, pelvis, and liver. She was told she had less than a five percent chance of being cured. Immediately after hearing “I think the main thing I try to convey is enjoy what you have, her diagnosis at Magee-Womens Hospital of UPMC, she pulled focus on what’s important,” Kate says. “Before my diagnosis, I was herself together and drove to Children’s Hospital of Pittsburgh of so busy and I felt like I couldn’t juggle the nonprofit, the kids, the UPMC to stoically accept a $20,000 donation from JP Morgan family and just everything that was going on. It took my diagnosis Chase for the nonprofit she established and leads. The organization, to really appreciate what I have.” Project Sweet Peas, prepares and delivers care packages to women and families dealing with premature births or the death of a newborn.

20 | UPMC CancerCenter University of Pittsburgh Cancer Institute | 21 YOUNG MOM DETERMINED TO FIGHT CANCER AND HELP OTHERS ALONG THE WAY

“Kate has a very serious diagnosis, but she’s been able to live her Also on Kate’s long bucket list are “teach kids to fly a kite,” “have a life,” says Adam Brufsky, MD, PhD, associate director of Clinical backyard camp night,” “go to a Christian concert,” “buy kids a swing Investigation at the University of Pittsburgh Cancer Institute and set,” and “take kids to the circus.” Those have all been crossed off. co-director, Comprehensive Breast Center, UPMC CancerCenter. Further down the list, Kate hopes for a trip to Ireland and seeing her “She’s turned it around and become a real inspiration to everyone children graduate from college and get married. Finding a cure for at the CancerCenter and elsewhere.” cancer also is on her list.

For Kate, the primary course of treatment was chemotherapy, Shortly after she was diagnosed, Kate blogged, “My faith won’t be but she developed an extreme allergic reaction to the first regimen. shattered. My hope won’t be forsaken … my soul will always be A second regimen, which she endured every week for 11 months, smiling … I will live life for now, around my cancer … I will love on my was more tolerable. Due to considerable pain and problems in her babies, my husband, and my family … I will feverishly work to fund pelvis, Kate opted for radiation to that area. She also received a breast cancer research.” targeted treatment with Herceptin®. She will continue with the Herceptin infusions every three weeks for the rest of her life. She is the embodiment of making lemonade from lemons. Literally. And every three months, she will get a full body scan. Kate, with the help of her family, friends, and the community, raised $30,000 for cancer research through LemonAID the Cure — a “I’ll friggin’ take it,” Kate said in her blog. Anything for more time lemonade stand (which was another bucket list item) — along with with her family. other fundraising.

“Kate’s done extraordinarily well, and I hope she’ll continue to do “I appreciate and love everyone at the CancerCenter. They’re my well,” says Dr. Brufsky. “And there’s no reason to think she won’t.” healing team. I really can’t give the UPMC doctors and nurses He noted the therapies administered to Kate were pioneered at enough praise and gratitude,” Kate says. “My infusion nurses were UPCI, one of them nearly 20 years ago, and remain the standard like my mom. They all called me kiddo. I talked to one of the chemo of care in many cases. nurses about absolutely everything.”

Lots of people seem to be taking note of just how special Kate is. So she wants to give back. And she wants to increase awareness Baby products company Kids II Inc. recently honored Kate as one of and understanding about this horrible disease, but also about the eight PinkPower Moms; Kate chose the Magee-Womens Research research advances and the potential for a cure. Institute & Foundation to receive the $9,000 prize money. Kate’s even become a bit of a media darling, having recently been featured “Dr. Brufsky is one of the leading oncologists in the country,” on MTV during the cable station’s #PinkPride programming, as well she adds. “He and others at UPCI were involved in the clinical trials as on Pittsburgh’s WTAE-TV and the FM-100.7 “Bubba Show.” for Herceptin and in the development of other cancer treatments. The research they’re doing right here in Pittsburgh is the stuff that “MTV was really neat. Yeah, that was the top of the coolness chart,” saves lives.” she gushes. “But meeting Bubba was on my bucket list; in my eyes, he’s a real celebrity. And he lived up to everything I hoped he would be.”

KATE CRAWFORD A FUTURE WITHOUT CANCER “I APPRECIATE AND WITH HER CHILDREN LOVE EVERYONE AT THE On Sept. 17, 2015, more than 800 of the region’s most future without cancer. UPCI and UPMC CancerCenter are CANCERCENTER. THEY’RE influential community leaders and supporters gathered focused on treatments for all types and stages of cancer, at CONSOL Energy Center for the 2015 Hillman Cancer with an emphasis on personalizing cancer care to ensure MY HEALING TEAM. Center Gala, A Future Without Cancer, to celebrate the that each patient receives the most appropriate prevention, I REALLY CAN’T GIVE THE 30th anniversary of UPCI and to recognize the life and detection, and treatment available for his or her condition. contributions of Elsie Hillman, who passed away in UPMC DOCTORS AND Event leadership included honorary co-chairs Elsie* and August 2015. NURSES ENOUGH PRAISE Henry Hillman, and Cathy and Sy Holzer and gala co-chairs AND GRATITUDE.” A Future Without Cancer helps provide crucial funding Debbie and Frank Coonelly, and Leslie and Jim Rutherford. for the research that takes us one step closer to a PNC was the presenting sponsor.

22 | UPMC CancerCenter University of Pittsburgh Cancer Institute | 23 2015 DONORS

2015 The Kramer-Neiderhiser Endowed Fund George Meanor Emma Clyde Hodge Memorial Fund in Blood Cancers Research Ms. Anna Piocquidio Karen Esposito for The Paul Esposito The Kramer-Neiderhiser Endowed Fund Foundation for Bile Duct Hilda M.* and Henry D. Sundermann, Jr. in Ovarian Cancer Research and Liver Cancer Gayle Tissue and Yiannis Kaloyeropoulos Mario Lemieux Patient Care and Cancer Gloria L. and Michael Fader Research Fund Bonnie W. and Thomas L. VanKirk, Esq. Diane M. Faust Nikol and Stanley M. Marks, MD Each year, UPCI and UPMC CancerCenter staffs are humbled by the Sally M. Levin Endowed Fund Barbara Ventura and Barry C. Lembersky, MD for Innovative Cancer Research Myrna and Mark Mason Debi Wheeler Gerald E. Feldman Scott Limbach Entrepreneurial Center The McKamish Family generous support of our donors. Clearly, we share a passion to put an Pete Wheeler Olja Finn, PhD and Seth Finn, PhD Robert J. Mann Memorial Fund Katie and David McSorley Kimberly and Curtis Fleming Stanley M. Marks, MD CIRCLE OF HOPE Donald A. Mosites end to the horrific suffering of patients and families afflicted by cancer. Robert and Ellen Flug Endowed Research Fund The Circle of Hope honors individuals, Theresa L. Nimick-Whiteside, PhD Jane France and Chris Allison The Liliana Muhlmann Masoner family foundations, and privately held Kevin Nord Cancer Fund companies that make contributions of Gary Frazier We appreciate your allowing us to recognize you here. And we cannot $10,000 or more in a year. This list Stuart Nord Drew Mathieson Entrepreneurship Fund Mary Louise and Henry J. Gailliot recognizes those who were members in Sandy and Gene O’Sullivan James A. Mollica Jr. 2014 and 2015, as of August 30, 2015. Patrick A. Gallagher thank you enough for your confidence in us and the work we do. Frank J. & Sylvia T. Pasquerilla Foundation Research Endowment Fund Ellen Goodman and Randy Crawford Anonymous (1) Kathleen and Demetrios Patrinos Parada Family Liposarcoma Frank and Mary Gorell Memorial Fund Cheryl and Bruce Americus Research Fund at the recommendation of Mr. and Mrs. Kenneth L. Payne Michael J. Parada Research Fund Patrice and Robert Americus Franklyn and Dale Gorell Cathy and John Pelusi Pasquerilla Cancer Genomics Wendy and David Barensfeld Tom Grealish Rosemarie and Kiran Rajasenan, MD ENDOWED CHAIRS UPMC Endowed Chair in Cancer Susan G. Komen Nathan S. Arenson Fund for and Proteomics Research Fund Rosalie Barsotti and Tony Poli Rhonda and Glen Gross David Rath Prevention Research Pancreatic Cancer Research A number of endowed chairs support the The Mario Lemieux Foundation Mark E. and Leah M. Pasquerilla Beckwith Family Foundation Susan and Barney Guttman Diana and Frank Rath mission of University of Pittsburgh Cancer UPMC Endowed Chair in Cancer Adriane R. Aul Memorial Fund Women’s Cancer Research Fund The Leukemia and Lymphoma Society Ken Bernstein Haleski Foundation Institute, partner with UPMC CancerCenter. Virology Research Lillian S. Rath The Keith F. Barket Mesothelioma PNC Innovation Fund The income generated from endowed chairs McCune Foundation Joan and Thomas Bigley Vicki B. and F. Robert Hall UPMC Endowed Chair in Head and Neck Research Fund Daniel Riggs enables our scientists, clinicians, and their Linda Saulle Endowed Memorial Fund Cancer Surgical Research James S. McDonnell Foundation Mrs. Donald Blechman Joan Harvey, MD Beckwith Family Foundation Endowed Rita McGinley Fund teams to strengthen established areas of Frieda G. and Saul F. Shapira and Michael T. Lotze, MD Richard King Mellon Foundation Eva Tansky Blum expertise, expand new initiatives, and forge UPMC Endowed Chair Research Scholars Program BRCA Cancer Research Program Roesch Family Foundation Hawksglen Foundation new frontiers in science that benefit our in Lung Cancer Research Metanexus Institute Richard M. Boccabella Donald Blechman Lecture in The Spang Translational Research Sharon and Jim Rohr patients and their families now and into Margaret and John Hill, MD N.S.A.B.P. Foundation, Inc. Surgical Oncology Core Facility Mary Ann and Chuck Bogosta the future. Stefania and Jeffrey Romoff VISIONARY SOCIETY The Heidi Browning Endowed Ovarian Elsie* and Henry Hillman Arnold D. Palmer 2003 Charitable Trust Joseph and Giovanna Tarquinio Barbara and Gary Bowser Diane and Cliff Rowe, Jr. The Claude Worthington Benedum These dedicated partners have given Cancer Research Scholars Fund The Pittsburgh Foundation Memorial Fund The William Talbott Hillman Foundation or helped to raise a cumulative total of Nancy B. Brent, MD Leslie and Jim Rutherford Endowed Chair in Radiation Oncology Ruth C. Brufsky Fund for Clinical Research $1 million or more in support of cancer PNC Financial Services Group Edward Thaw Blood Research Fund and David A. Brent, MD Cathy and Sy Holzer The Jane and Carl Citron Endowed Chair on Pancreatic Cancer Athena Sarris research and care. and PNC Foundation Edward Underhill Memorial Fund Jill and Adam Brufsky, MD, PhD Joel M. Hullett, MD in Colon Cancer Mikell and Bill Schenck III Patti Burns Fund for Colon Cancer Research Myles D. Sampson* and Family Jodi and Seth Brufsky The Mary Hillman Jennings Foundation The Richard M. Cyert Endowed Chair American Cancer Society, Inc. Tracy and Evan J. Segal Al Copeland Memorial Fund for Dr. Leonard S. Zombek Memorial Fund in Molecular Oncology Sanofi-Aventis Carl Dale Cameron Janis and Jonas Johnson, MD Family and Friends of Nathan S. Arenson* Merkel Cell Carcinoma Research Barbara and Herbert Shear The David S. and Karen S. Shapira The Gregory T.H. Davies Endowed Chair Claude Worthington Benedum Merrill J. Egorin MD Scholars Program Carl and Beth Campbell Tricia and Bill Kassling Foundation PLANNED GIVING Shirley Hobbs Martin Memorial Fund in Brain Tumor Research and Foundation Wayne Fusaro Pancreatic Cancer Christina and Carlos Cardoso Karen and Joseph L. Kelley III, MD Physician Education Barbara and Herbert Shear The University of Pittsburgh Cancer Institute, The Honorable Jacqueline O. Shogan The Breast Cancer Research Foundation Research Fund partner with UPMC CancerCenter, gratefully Josephine Chaus Kathy and Cary Klein The Lawrence Ellis Endowed Chair Gayle Tissue and Yiannis Kaloyeropoulos Shirlie and Owen Siegel Foundation Susan and Alan Citron acknowledges planned gifts from the in Hematology and Oncology Sadie Gerson Distinguished Visiting Susan and Alan Citron Koch Family Sandra and Thomas Usher Scholar Program following individuals: Edgar Snyder Carl Citron* The Bernard Fisher Endowed Chair Mary and Jay Cleveland, Jr. Valerie R. Koch The V Foundation for Cancer Research Stuart Goodman Brain Cancer Patricia G. Snyder in Surgical Oncology DSF Charitable Foundation Anonymous (1) Carrie and Adam Cohen Curtis I. Kossman Foundation Memorial Fund Debi Wheeler Rebecca Snyder The Giant Eagle Foundation Flight Attendant Medical Cheryl and Bruce A. Americus Frances and Corky Cost Kim and Don Kramer Peter E. Hackney Fund for Endowed Chair in Cancer Genetics Research Institute Wheeler Family Charitable Foundation Sandy Snyder Pancreatic Cancer Research C. Dale Cameron Crawford Consulting Services Anne Gendler and David Leib The Hillman Endowed Chair in Oncology Giant Eagle Foundation Pete Wheeler Patricia and William Snyder Harvey G. Herberman, MD Helen and Donald E.* Chrise Joseph Curtin* Nathalie and Mario Lemieux The Arnold Palmer Endowed Chair Teresa Heinz and The Heinz Endowments Elaine and James Steinfurth Memorial Cancer Research Fund Alfred A. Dybeck Carol and Robert Cypher The Judith A. Lese in Cancer Prevention FAMILY LEGACY SOCIETY Stork Foundation Harriett L. and Ronald B. Herberman, MD* Breast Cancer Foundation Dr. George W. Hiett Foundation Fund Daniel Edelstone, MD Randi and *L. Van V. Dauler, Jr. The Pittsburgh Foundation Endowed Chair Often, a personal experience with cancer or Elizabeth L. and John P. Surma Highmark Foundation Dr. Herbert E. Jacob Memorial Fund Robert Levin in Innovative Cancer Research loss of a loved one to the disease spurs a Deborah S. Feckett Rhode Nancy E. Davidson, MD Gayle Tissue and Yiannis Kaloyeropoulos Elsie H.* and Henry L. Hillman family or others to establish funds that honor and Thomas Kensler, PhD Sally Levin* The Sampson Family Endowed Chair Hyman I. Katz Cancer Research Fund Susan G. and Barney C. Guttman a patient or caregiver through support of Bonnie and Tom VanKirk in Thoracic Surgical Oncology Hillman Foundation Barbara Klump Memorial Harriett L. and Ronald B. Herberman*, MD Jamini Vincent Davies Anne Lewis continuing efforts to better detect, prevent, Henry L. Hillman Foundation Scholarship Fund William F. and Lynn D. Gauss Foundation The Sandra and Thomas Usher and treat cancer. Margaret M. and Jack B. Hill, MD Mary Lou and Richard Durr Limbach Family Fund Endowed Chair in Melanoma Frank W. Knisley Memorial Fund Jeanne and Larry Williams Family and Friends of Albert P. Knowles* Sally E. and Peter S. Kay Susan* and Daniel Edelstone, MD Christine and Jim Luketich, MD Suzanne Hill Alfano Endowment for UPMC Endowed Chair in Advanced New Era Cap Charitable Foundation and Albert P. Knowles Research Fund Sally and Craig Wolfanger Lung Cancer Research Eugene and Ruth Anne Klein Antoinette and Robert P. Edwards, MD Nancy and Philip Lundman Oncologic Head and Neck Surgery Family and Friends of David C. Koch* David C. Koch Memorial Fund Sarah and Ray Lamont Peter G. Ellis, MD Cheri and Joe Manzinger

24 | UPMC CancerCenter University of Pittsburgh Cancer Institute | 25 2015 2015 DONORS DONORS

Richard A. Chesnik, Esq. John H. Kurtz III Anthony R. Ricottone, MD Denise and Daniel J. Birsic, Esq. Gary R. Luchini Timothy V. Wieseckel Linda W. and G. Reynolds Clark Thomas A. Labert Deborah M. and Harry Rosen W. Richard Blackwood Daniel E. Luko Jr. William D.G. Wyckoff David A. Clump II, MD Steffi Oesterreich, PhD Louisa S. Rosenthal* Bernice H. Bollman Victoria Madero-Arnold Jian-Min Yuan and Adrian V. Lee, PhD Malindi Davies and Raj Dhaka Nancy A. Rozendal and Gordon Lisker Miss Lois Lee Bortner Dorothy J. and Scott F. Mann David M. Zubrow Susan and Louis E. Leff, MD Sarah Davies, MD, DDS Dale Schwegler Barbara Ann Brooks Helen B. and Curtis R. Marquard ($250 - $499) ANNUAL GIVING and Benjamin J. Davies, MD Alice Laffey and Peter P. Leone Jr. Calvin L. Johnston Tracy Robin Seewald, MD David E. Brougher, MD Lawrence Mazzotta Daniel Acker The annual fund provides vital support for Nicholas J. DeIuliis Sandra Levin and Steven A. Burton, MD Thomas I. Keeler Sr. Rebecca A. Brown John R. McConaghy, MD the operation of clinical programs, basic and Olive M. Tiller and Edward J. Alo Rita DiChiera Elsie Y. Lewis Katherine A. Servich James T. Knox clinical research programs, recruitment of Sylvia S. Bucci Gary L. McDaniel T.J. Angelo Gary Dille Gregory L. Lignelli Patricia A. Shaffer Thomas A. Labert new physicians and scientists, seed money, John W. Chapman Linda McLain Mary C. Ballerini medical and patient education, and outreach Susan S. and Roy G. Dorrance III Judith K. and Ronald G. Linaburg, DMD Donna M. Sherman Donna L. Lample Joseph R. Chapman William J. Medica programs. Those listed have made gifts at Joanne B. and Jeffrey P. Bissell Laura E. and Alfred P. Doyle, MD Edward T. Liverani Rhoda F. Sikov John A. Lech, DO the following levels during the fiscal year Andrew J. Clark Janet M. Miller Ellen T. Bongartz 2015 (July 1, 2014 – June 30, 2015). Karen K. Egorin Michael Livingston Debra and Mark A. Sindler Brian Lloyd Courtney N. Clarke Natalie D. Miltenberger Kathleen M. Bradey Tracy and Lee E. Elder Amy and Gavin Mann Marilyn and Norman A. Sindler Thomas E. Long III ($5,000 - $9,999) Jeffrey J. Claycomb Christine Moore Demrey G. Brandon Jonathan Engh, MD Judith and James Matheny Marquis M. Smith Jr. David A. Love Frances A. and Charles S. Armitage Sr. Shelley Wyckoff Clement Donald E. Moore Daniel L. Bridge Sally A. and Terry L. Evans, MD Jerry C. McConnell Sally M. Snyder and Lee F. Snyder Diane E. Lucas Gregory J. Clawson Thomas G. Cooney Sr. Thomas M. Mulroy, Esq. Regis J. Bridge Christine M. Fulton and George A. Fechter Cicely C. McCreight Mark A. Socinski, MD Ernest F. Magario William S. Conover II Michelle Deng Melonie A. Nance, MD Shirley B. and George E. Campbell Jr. William N. Ferguson Martin G. McGuinn Jane Spangler and Uma Duvvari, MD Anthony Maher Parteni Danek W. Craig Esterly Darlene K. and Geary L. Carter Laura K. Ferris, MD Thomas J. McKinney Jeffrey W. Spear, Esq. Jeanne Naylon Stanley T. Malec Michael and Gloria L. Fader Fred P. Fanto and Robert L. Ferris, MD Julius R. Casali Melissa L. McLane Lynn Staudt Robert Paul Oeler Diane A. and Chronis Hazi Manolis Lilian H. Fisher John H. Feist, MD James R. Fitterling Janet Cholewinski George E. Meanor Susan R. and George L. Stewart II Ellen M. Ormond, PhD Michael Egan and Dawna Martich Lee B. Foster II Mark L. Flock Lanie K. Francis, MD and Elie Francis, MD James W. Christy Jr. Allan H. Meltzer Janet S. Stewart Dorothy N. Osmundsen Althea L. McCalmont Stuart Hayim Richard D. Frank Douglas A. Freeman Jo-Ann Churchill Michael D. Minton, MD Michael Swindell Hairong Peng, MD Jean H. McCullough Amy M. and Dennis J. Kelleher J. Peter Freed Jill Fusaro Greeta Cohen Lesley Moffett-Krause Julia H. Tamkevicz* Shirley Perales James McDonald Richard Kelly Randy Freno Alan L. Gabriel Paul A. Cooney Donald A. Mosites Kathleen M. and Louis L. Testoni Robert F. Perdziola Loretta M. McElhattan Nancy S. Krieger Philip W. Gasiewicz Paula and Martin G. Giglio Richard A. Crillo Steven T. Mosites William H. Trippler Cindy J. Piendl Daniel R. McLachlan* Janet M. Levin and Frank J. Gruber Susan Gibson Maryedna Gillespie-Gennaula Patricia Croll Marc Nemer Victoria M. Woshner, DVM, PhD Deborah L. and Anthony M. Prentiss Nancy R. Mead Amy Malaney Sandra Green Goodman William F. Cygnarowicz Stephen A. Glickman and Bennet Van Houten, PhD F. Joseph Miller William H. Mallinson Barbara Netter and Lee S. Goodman Jonathan Raso Salvatore Davide Megan and Robert I. Glimcher Jay Vetere Robert W. Noble Eric A. Peter Ann K. and William R. Newlin Patrick H. Gurrentz Ann A. Rogers Norman Dennis Lee and J. Roger Glunt Dolores and J. Franklin Viverette, MD John A. O’Cilka Juliet L. Simonds Margaret H. and Jack Offenbach Rodger Gurrentz Joan and Ronald M. Rothaus Norma Dixler Nancy B. Gold-Cohen Denise K. Voloshin, MD Robert Paul Oeler Kenneth J. Spangler Thomas J. Osborn Charles Hanecek Jr. Glen E. Schumann and Steven H. Cohen and Michael D. Voloshin, MD Sarita G. and Milton Eisner Kathryn Ann Paladino, PhD Betty Jean and Henry B. Higman, MD Carol Scicutella, DO and Greg Krivacek Dawn Orange John M. Vautier Carl G. Grefenstette William Wagner and Peter T. Paladino Jr., Esq. D. Diane Eldred Lauren Denny Hirsch Ralph L. Scott Ellen M. Ormond, PhD Stephen R. Guy, MD Xiaoyan Cai and Zhou Wang, PhD ($1,000 - $4,999) Kathleen and Demetrios T. Patrinos Richard M. Esposto William A. Hite Bonnie Seaton Anthony J. Pagliai Jo Ann Haller, Esq. Barbara R. Watters Rachel and Nduka M. Amankulor, MD Teresa I. and Jeffery David Peters, Esq. Daniel E. Evans III and Daniel C. McGrogan, Esq. David R. Hoch Amy R. Sheehy Betty S. Parsons Paul S. Weiss Maureen M. and Eric N. Anderson, Esq. Suzanne K. Morrissey, MD Lillian V. Ferguson Scott J. Hamill Jack F. Holsing J. Matthew Simon, PhD* Richard Perella Amada and Rashid A. Awan, MD and Daniel P. Petro, MD Karen and S. Rand Werrin, DDS Nola Ferrari Nancy Hamilton Daniel C. Hostetler Janet Di Pasquale Simon, PhD Eva P. Pinkerton Susan J. and David L. Bartlett, MD Jill Petros Patience D. Wessel Patricia D. Funk Thomas M. and Loretta L. Hanwell Joe R. Irwin Joanne Ross Simon John Podoletz Christine and Richard Pfingstler Lin Zhang, MD and Jian Yu, PhD Julie E. Bauman, MD and Benjamin W. Simon Edward C. Furlong Charles W. Harbaugh John E. Jerge Terri L. and James C. Polacheck Michael Pignatiello Linda R. Zajdel Barbara A. Dappert, MD David E. Snyder Anthony C. Giunta Barbara A. Heigl Carole and Daniel G. Kamin Jonathan Raso and Michael J. Becich, MD, PhD Debra and Ornella and Hassane M. Zarour, MD Charles E. Stine James Gosman Sarah J. and C. Talbot Heppenstall Jr. James F. Pingpank Jr., MD, FACS Gauri J. Kiefer, MD and Jan F. Kiefer Susan H. and John Alden Redfield, PhD Dominic N. Bertucci Anton and Janet Zidansek Henry B. Suhr Jr. Donna P. and Ralph E. Grabowsky Edward M. Klaman Colette D. and Jean-Francois Richard, PhD Elaine C. and Thomas M. Hill Jodi A. Pitchok James P. Talarico Mary Grenen, Esq. The Honorable Alan N. Bloch ($500 - $999) John R. Kneedler Herbert Richardson Aura R. Hulme Gabriela Powell and James F. Grenen, Esq. Sara B. Thompson D. H. Bovbjerg, PhD William Adams Rita M. Kocjancic Maureen Romano Edward W. Icardi Charles D. Prestopine Judy and Harold E. Haffner Geoffrey Tither Susan and Michael Boyle Anuradha Ashwat Wayne K. Kong Thomas Saulle Roy T. Johnson Donna Puleio, MD and Gary Thompson Sue E. Hall Barbara E. Trachtenberg Betsy Levine-Brown and Marc L. Brown Joseph D. Balsone Bert J. Lamport III Noellette Conway-Schempf, PhD Margaret M. Kanaan Edwin M. Purviance, Esq. Betty L. and Barry C. Harris, MD Steven Van Wyk and Hagen Schempf, PhD John P. Burke Kathryn A. Barbustiak John A. Lech, DO Irene Getzie Kane, PhD and Kevin M. Dale Pysher Chad Henschel Helen G. and Col. James Nolan Vernon Doris M. Scott Lisa H. Butterfield, PhD Kane, MD Marian C. Baur Marina Persic Lehn, Esq. Ann T. and Robert W. Queale, DDS Pablo Hong-Barco, MD and Kenneth M. Lehn, PhD Domenica T. Vogel Margaretha L. Casselbrant, MD David N. Kaplan James R. Baxter Manikantan K. Ramakrishna Ada M. Hutchison Daniel L. Kelly Jim Baxter Chih-Tsung Kang, PhD Marcia J. Weiss Yuan Chang, MD Sally and Ned Randall and Li-Yin Lin, PhD Marilyn and Daniel David Infante and Patrick S. Moore, MD Dusty Elias Kirk Susan S. and David Becraft Debi Wheeler Alan H. Resnick, MD James Service

26 | UPMC CancerCenter University of Pittsburgh Cancer Institute | 27 2015 2015 DONORS DONORS

BUSINESSES, CORPORATIONS, Comptec, Inc. Mascaro Construction Company, LP Kathy Vetere Cancer Research PL Restaurant Associates LLC Fidelity Charitable Gift Fund ADVOCACY ASSOCIATIONS, Cost Company Mason Contractors Association Key Environmental, Inc. Preferred Licensing Services Incorporated The Wendy and David Barensfeld AND OTHER GROUPS Family Charitable Fund Cyclic Vomiting Syndrome Association Menlo Worldwide Logistics Laborers District Council of Western S. M. Cristall Co., Inc. The University of Pittsburgh Cancer Institute, Pennsylvania The Esterly Fund partner with UPMC CancerCenter, gratefully Franco Associates Moderna Therapeutics, Inc. Splash Water Sports, Inc. LXR Travel, LLC The Gaylick Fund acknowledges gifts of $250 or more from GlasRock Products, Inc. Mosites Construction Company The Benevity Community Impact Fund Kathryn W. Shahin businesses, corporations, advocacy Matt Mertz Plumbing Inc. Mr. and Mrs. Patrick H. Gurrentz ($10,000 - $24,999) Grey Oracle Corporation Western Pennsylvania associations, and other groups. Marcia H. Smith and Dr. Peter A. Simon McKnight Realty Partners LLC School for Blind Children The Manzinger Charitable Fund A Glimmer of Hope Foundation H. Mak, Inc. P. J. Dick Incorporated William J. Simpson ($100,000 - $499,999) Milliken & Company Willet Dairy, LLC The Osborn Charitable Trust The Audrey Hillman Fisher Foundation Jewish Federation of Greater Pittsburgh PricewaterhouseCoopers LLP James H. Smith American Cancer Society, Incorporated Mistick Construction Co. Zubin Custom Homes, Inc. The Rozendal Charitable Gift Fund Gailliot Family Foundation Jones Day Project Purple Kelly Smith American Lung Association Navarre Minerals Company The Sagonowsky Family Fund William Talbott Hillman Foundation Miles Against Melanoma 5k PA RTI International Metals, Inc. ($250 - $499) Joseph M. Spirer GENCO New Alexandria Lions Club, Inc. The David E. and Sandra J. Snyder Howard Hughes Medical Institute Millennium Pharmaceuticals, Speed Motor Express of W.N.Y., Inc. 43rd Street Concrete Charitable Gift Fund Christine Stanko Life Raft Group Incorporated New Era Park Caps The Judith A. Lese Sysco Pittsburgh, LLC ADPRO Sports Lungevity Foundation Breast Cancer Foundation, Inc Paul K. Stefko Melanoma Research Alliance Morgan Stanley Smith Barney LLC Norwin Elks Lodge No. 2313 Takeda Pharmaceuticals U.S.A., Inc. AK Sales, Inc. NSABP Foundation, Inc. Frank J. & Sylvia T. Pasquerilla Foundation Susan L. Stepchuk Ovarian Cancer Research Fund New York Yankees Nuance Communications, Inc. TriState Capital Bank Carnegie Mellon University Football Team Riggs Family Foundation Bobb M. Stevens Sarcoma Alliance for Research Normandy Industries Inc. Onyx Pharmaceuticals Inc ($50,000 - $99,999) Vautier Communications, Inc. The Department of Anesthesiology Through Collaboration Roesch Family Charitable Trust Susan K. Stonebraker Pennsylvania Breast Cancer Coalition Paragon Wholesale Foods Walk of Hope - Friends of Kathy Tylka at Shadyside Hospital Beckwith Family Foundation Shanghai Longyao Bio-tech, Inc. Stork Foundation Leilani T. Stritter Phillips Lytle LLP T. D. Patrinos Painting Friends of Zola Munter Doris Duke Charitable Foundation United Way of Allegheny County ($1,000 - $4,999) & Contracting Company We Wish Inc. Elizabeth B. Strycharz Pink Pamper before Pittsburgh Associates Harrison Consulting Group The Frank E. Rath Spang & Company ADPRO Sports The Philadelphia Phillies Charitable Trust James D. Sullivan ($50,000 - $99,999) Pittsburgh Associates Lloyd Crane & Equipment, LLC ($5,000 - $9,999) AK Sales, Inc. Pinnacle Peak Foods, Inc. The Pittsburgh Foundation Leslie W. and Jan C. Swensen American Association for Cancer Pittsburgh Steelers LLC Lloyd’s Rental & Sales, Inc. Children’s Hospital Research American Bridge Company Pittsburgh Post-Gazette The Deno F. Barsotti Family Fund of Pittsburgh Foundation Reverend John W. Swoger Project Purple The Martin Group LLC Denise’s People American National Skyline, Inc. PNC Financial Services Group, The Elanie C. Bloch and The Honorable The Foster Charitable Trust Mark E. Thompson, MD S.T.O.M.P. Out Cancer before Tailgate Police and Firemen’s Insurance Hackers for Hope Andrew Sariochek Memorial Fund Incorporated Alan N. Bloch Fund Elaine E. Tokosh for the Cure Association The Foundation For Jewish Philanthropies Pittsburgh Cure Sarcoma AVI Foodsystems, Inc. Quagga Accessories, LLC The Jane Dolan Conover and Edith K. Trewin Tailgate for the Cure Quality Auto Parts Inc. The Shore Fund Radelet McCarthy Polletta, Inc. Architects William S. Conover Fund Walgreens Specialty Pharmacy Bison Baseball Inc. R.D. Harrer Construction Corporation The Juliet Lea Hillman Simonds Verena P. Turner ($25,000 - $49,999) and Interior Designers The Nancy T. and Foundation, Inc. Westmoreland Country Club Bob Fryer Memorial Fund Salary Personnel Barbara R. Ventura Brain Cancer Awareness 5K RBC Capital Markets, LLC William S. Conover II Fund at Fuzion Technologies, Inc. Bond, Schoeneck & King, PLLC ($1,000 - $4,999) Gary D. Veshecco Celgene Corporation ($5,000 - $9,999) Reed Smith LLP The Jane M. Epstine Charitable Fund Tempur Sealy International, Inc. Bricklayers & Allied Craftworkers Community Foundation John P. Waldron CONSOL Energy Inc. American Textile Company The Frank and Local 9 Pennsylvania Ridilla Family Partnership Upper Saint Clair High School Mary Gorell Memorial Fund for the Alleghenies Marcia J. Weiss Highmark Arthurs Philanthropic Fund Bristol-Myers Squibb Company Roswell Park Cancer Institute Ventana Medical Systems The Grambrindi Davies Fund The Flower Barn at Grandview Carol Westlake Ladies Hospital Aid Society of Bakery Square Holdings, LP Carnegie Mellon University RYWTF Golf Outing Greenhouses Fund Western Pennsylvania The Gertude E. Hellerman Janet G. Whetsel Bayer Corporation Cerner Corporation Schenley Park Advisors FOUNDATIONS Charitable Trust Fund George R. and Janet E. Desko The Leukemia & Lymphoma Society Nedra G. White Blue Marlin Systems Inc. Charitable Foundation Champs Sports SeattleGenetics University of Pittsburgh Cancer Institute, The James T. and Hetty E. Knox Fund Plum Running Mustangs James E. Wilson Bowser Pontiac, Inc. partner with UPMC CancerCenter, gratefully The Fine Foundation Chapman Properties Sisterson & Co. LLP The Limbach Family Fund Alumni Assn., Inc. acknowledges the foundations that have Shara L. Zeunges Cohen & Grigsby, PC St. Clair Hospital Nina Baldwin Fisher Foundation UPMC Health Plan Dendreon provided support of $250 or more to further The Rubinoff-Durham Family Fund Dorothy K. Zikos Deloitte Services LP our mission. The Lilah Hilliard Fisher Foundation, Inc. Dickie, McCamey & Chilcote, P.C. UPMC CancerCenter Employees The Dr. Mark E. Thompson Fund ($10,000 - $24,999) Dollar Bank The Matthew Hillman Fisher Dow Chemical Company PAC Match Wabtec Corporation ($1 Million+) The Theresa L. Whiteside-Nimick Fund ESTATES A. C. Dellovade, Inc. Foundation, Inc. Dudley Enterprises Inc. Drinker Biddle & Reath LLP Wells Fargo Bank, N.A. The Breast Cancer Research Foundation Sarcoma Foundation of America, Inc. The University of Pittsburgh Cancer Institute, AEC Group, Inc. Wayne Fusaro Pancreatic Cancer Easley & Rivers, Inc. partner with UPMC CancerCenter, gratefully Elder Ag & Turf Equipment Co. Yates-Fund for Cancer Hope Hillman Foundation Research Fund American Academy of Otolaryngology- ($25,000 - $49,999) acknowledges gifts from the following Eat’n Park Hospitality Group, Inc. Head and Neck Surgery Ethicon Endo-Surgery ($500 - $999) Henry L. Hillman Foundation Robert I. Glimcher Family Foundation individual estates and trusts: Community Foundation of Western PA Eli Lilly and Company Federated Investors Incorporated & Eastern OH Gertrude E. Hellerman American College of Radiology CJL Engineering ($500,000 - $999,999) Estate of Lucian Caste Elliott Ebara Group Charitable Trust Fund Friends of Jeannette F. Kraus The Maple Lane Farm Fund Amgen Curves of Mt. Lebanon Susan G. Komen George J. Kastlin Trust Epic The May Kay Houck Foundation Arthurs Malof Group Giant Eagle, Inc. D’Arcangelo & Co., LLP The Team Danielle Fund Estate of Sally M. Levin Ernst & Young LLP ($250,000 - $499,999) The Roy F. Johns, Jr. Family Foundation AstraZeneca Pharmaceuticals LP The Hillman Company Google, Inc. Haleski Foundation Estate of Julia H. Tamkevicz Foot Locker, Inc. Alliance for Cancer Gene Therapy Out of the Woods Foundation Bio-Theranostics Hopewell Girls Soccer Booster Assn. Goya Foods Great Lakes Pittsburgh Penguins Foundation Frank Calandra, Inc. The Mary Hillman Jennings Foundation Shadyside Hospital Foundation Boehringer Ingelheim IBEW Local Union No. 5 Knoechel Heating Co. Charles F. Spang Foundation Pharmaceuticals Inc. Genomic Health, Incorporated The Mario Lemieux Foundation World Wide Technology Foundation IBM Employee Services Center NWPA APA Poolplayers The William I. Buchanan Ingersoll & Rooney PC Hefren-Tillotson, Inc. and Patricia S. Snyder Foundation Image Associates, Inc. On LLC ($100,000 - $249,999) The Buncher Company Hewlett-Packard Company The Woiner Foundation Inferno Baseball Inc. Parke Interiors, Inc. The Ellison Medical Foundation Canon Business Process Services, Inc. IBM Corporation James Service Pediatric Ophthalmology The Fashion Footwear Charitable Johnson & Johnson & Strabismus Specialists Inc. Foundation of New York, Inc.

28 | UPMC CancerCenter University of Pittsburgh Cancer Institute | 29 2015 DONORS EVENTS

Stephanie K. Dutton Peter G. Ellis, MD Michael T. Scheponik John L. Galley EQT Corporation Michelle Schreiber IT TAKES A VILLAGE: HOW OUR NEIGHBORS CONTRIBUTE TO THE SEARCH FOR A CURE Michael Grace Diane M. Faust Tracy Robin Seewald, MD and Barry C. Lembersky, MD and Steven A. Burton, MD Mr. and Mrs. Craig B. Fiedler Brandon J. Fischbach Michael F. Shaw Brian J. Fritz Last year, STOMP raised more than $22,000, Hospital of Pittsburgh of UPMC also benefits; ($250 - $999) Karen H. and Robert Fisher Joanne M. Silowash BRAIN CANCER AWARENESS 5K Dorothy E. Fukas Brain cancer is often overlooked: not many and, over the past eight years, the event has the event supports the hematology/oncology The Ayco Charitable Foundation Reid J. Fleming Michele Sparkenbaugh Barbara and David Horne organizations work to raise awareness of this established an endowment of more than pediatric fellows program. For more information, The E.V. Randall, Jr. Family Fund Brian J. Fritz Patrick M. Stabile Mr. and Mrs. Edward T. Karlovich deadly disease, and it rarely garners much $127,000. In 2009, the Western Pennsylvania visit www.hackersforhope.org/pittsburgh. Dollar Bank Foundation Joseph L. Furmanski James St. John Kristen S. and William D. May attention from the press. But one group is Chapter of the Association of Fundraising Silicon Valley Community Foundation Susan Gibson Steven R. Strain Joyce A. Metnick planning to change that. Professionals recognized Evans City with its OTHER EVENTS Jack S. Goldsmith Georgina A. Trunzo Many members of our community work to Marie A. and David B. Navikas Outstanding Youth in Philanthropy Award. All UNITED WAY Aug. 22, 2015 was the date of the Second Michael J. Hardobey Cynthia D. Warsing support cancer research at UPMC CancerCenter Barbara and Albert J. Neupaver proceeds from STOMP benefit UPCI. To learn The University of Pittsburgh Cancer Institute, Annual Brain Cancer Awareness 5k, which Stephany Hartstirn Andrew A. Yohe more, visit www.svsd.net and click the Evans and UPCI, and we sincerely appreciate their partner with UPMC CancerCenter, gratefully Suzan and Brian O’Brien took place in the heart of White Oak Park in City Elementary link. contributions. Here are a few organizations that acknowledges donors who designated Paula L. and Bradley Hencel Wendy Lee Zellner White Oak, Pennsylvania. This year, 425 Donna Puleio, MD have dedicated their time and talents to the United Way donations and/or pledges of Christa S. Hlavsa Diane H. Zilko runners participated, up from 250 in 2014. $250 or more in support of UPMC Jodi A. Pitchok STAMPEDE IN THE PARK ongoing search for a cure: Diane Holder and Gerald D. Holder, PhD The race organizers, who are in the process of CancerCenter and the University of Jeffrey Marc Porter On July 23, 2015, approximately 350 runners Pittsburgh Cancer Institute agency Leslie S. Hyde and Louis Santora UPMC CANCERCENTER AND forming a nonprofit group, share a common •• Pink Pamper Sandra L. Rader and 250 spectators came together in Boyce codes during the 2014 United Way THE UNIVERSITY OF (women’s cancers) Brian J. Karlovits, DO bond: either they or their loved ones have been and United Way Campaign Richard Skubak PITTSBURGH CANCER INSTITUTE Park, in Plum, Pennsylvania, for the tenth annual treated for brain cancer at UPMC CancerCenter. Information: 412-855-6822 (June 2014 through May 2015). Nancy and Stanley Lehman DEVELOPMENT DEPARTMENT Stampede in the Park, a 5k run sponsored by the Howard I. Sniderman •• Denise’s People Amy L. Lenker Kellie Anderson, Interim President, Their positive experiences with our physicians, Francis X. Solano, M.D. Plum Running Mustang Alumni. The event raises ($10,000 - $24,999) Medical and Health Sciences Foundation nurses, and other caregivers led them to form (brain tumor research) Phillip G. Levasseur Stacy and Donald E. Splitstone funds for leukemia and lymphoma research at Joan and Thomas G. Bigley Paula Hencel, Major Gifts Officer an organization to raise funds exclusively to Information: 724-482-2984 Richard A. Liebscher UPCI and Hillman Cancer Center. Janet Tripodi Mary Ann and Chuck Bogosta Tara Covelens, Major Gifts Officer support research at UPCI. •• Maple Lane Farm Karen J. Light Wabtec Corporation Joe Ionta, who has coached the cross country (nurse education fund) Christina and Carlos M. Cardoso Eleanor Flannery, Program Manager Paula J. Lounder In 2014, the Brain Cancer Awareness 5k raised Charles B. Watson team at Plum High School for more than 30 Information: 724-679-8259 Kimberly T. and Curtis D. Fleming Meghan Boehm, Administrative $25,000 for research. On August 13, 2016, they Shelley and Douglas J. Lucas years, found out 10 years ago that he had Woiner Foundation: 3-2-1 Ride Tom Grealish Sharon and Robert W. Welch Coordinator hope to increase that number and educate even •• Jeffrey C. McKibben chronic lymphocytic leukemia. This diagnosis (melanoma program) Janis C. and Jonas T. Johnson, MD Darlene and John Wisniewski more people about their cause. To learn more James J. McQuade spurred his group to create the event to raise Information: 844-321-7433 Nikol and Stanley Marks, MD Raymond B. Wynn, MD about the group’s mission, visit www.active.com/ Teresa A. Moore funds for research. Ladies Hospital Aid Society Bonnie W. and Thomas L. VanKirk Theodore W. Zierden white-oak-pa/running/distance-running-races/ •• Carmella R. Nachreiner brain-cancer-awareness-5k-2015. This year’s race was run in memory of Rachel (various programs) ($5,000 - $9,999) ($250 - $999) Patricia A. Newingham Twigg, a former Running Mustang who passed Information: 412-648-6106 Consult USA Cynthia K. Adams Rachel and Eric S. Newman STOMP OUT CANCER away from osteosarcoma. In nine years, •• Pittsburgh Cure Sarcoma Ellen R. Goodman and Randall Crawford Stefan M. Ahlers Theresa L. Nimick-Whiteside, PhD Many of us have fond memories of our first Stampede in the Park has contributed more (sarcoma research) Ann and Martin G. McGuinn Colleen P. Bayko teachers. In Evans City, Pennsylvania, the children than $210,000 for cancer research. Information: 724-622-5712 Sharon M. Phillips Ann K. and William R. Newlin Brooke A. Bejster of the Seneca Valley School District honor the •• Carnegie Mellon Athletics Nathaniel C. Pugliese HACKERS FOR HOPE Donald D. Reifner Lauren Belot memory of a beloved teacher every year by (breast cancer research in memory of Lowell A. Sams On May 20, 2016, approximately 200 golf Virginia Brown marching in an event called STOMP Out Cancer. Cynthia Lackner) ($1,000 - $4,999) Louis Gerrard Santora *Deceased enthusiasts will come together at the Longue Information: 412-268-3894 Kristin F. Burns STOMP, which stands for Saulle’s Teddybear Mary H. Berkebile, MD and Jack Berkebile Vue Club in Verona, Pennsylvania to raise funds Kimberly Ward Burns, Esq. Official Memorial Parade, refers to Mrs. Linda •• A Glimmer of Hope Richard Bondi to support cancer research and treatment. and Robert L. Burns Jr., Esq. Saulle, who taught kindergarten for 17 years at (various programs) Mr. and Mrs. Norman Bourdeau Hackers for Hope is a golf marathon event: up to Deborah L. Calderazzo Evans City Elementary. Her annual Teddybear Information: 800-454-6746 16 golfers solicit pledges and sponsorships and Noel and Christian G. Carmody Picnic was always a favorite event. She died of •• Chris4Life Scott A. Cerilli then play as many holes of golf as they can in Molly and Thomas G. Crooks cancer in 2007 and is still greatly missed—but (colon cancer) Alexander J. Ciocca III one day. The event, which is open to the general Nancy E. Davidson, MD her influence lives on. Evans City Elementary and Information: 1-855-610-1733 Tracy L. Cunningham Every gift to UPMC CancerCenter and the University of public, ends with a dinner party featuring a silent and Thomas W. Kensler, PhD Middle School children devote one day every year •• Grant Channell Memorial Anthony E. Demarco Pittsburgh Cancer Institute plays a vital role in advancing auction and live entertainment. Roseann DeGrazia to raising money and awareness in the hope of (melanoma research; 21 years of support) Douglas Durham Amy and Robert A. DeMichiei research and enhancing patient care. Unfortunately, space finding a cure. Iceburgh, the mascot of the Hackers for Hope is an event that grew from Information: 412-623-7707 Sean R. Edwards is too limited to list the individual names of the many donors Pittsburgh Penguins, joined the kids in 2014. a gathering of longtime friends who had each •• Tailgate for the Cure experienced cancer among their loved ones who gave gifts at levels of $1 to $249. Please know your During the parade, the children carry banners (cancer research) bearing the names of loved ones who have and wanted for find a way to help others. They Information: 412-440-7558 support is truly appreciated. If we have made any errors in experienced cancer. identified a specific program—the BRCA registry any name or omitted anyone from this list, please accept program at UPCI—and, in six years, have raised Annual giving donors listed are from Fiscal Year 2015. more than $300,000 to support it. Children’s Circle of Hope donors listed are from calendar year 2015, as of August 31, 2015. our apologies and notify us by calling 412-623-4700.

30 | UPMC CancerCenter University of Pittsburgh Cancer Institute | 31 BRIEFS

UPCI DISTINGUISHED AS NCI COMPREHENSIVE CANCER CENTER, AWARDED GRANT RENEWAL

In July, UPCI learned its National Cancer Institute Comprehensive Cancer Center designation was renewed. The highly coveted award recognizes world-class multidisciplinary research. UPCI is one of just 45 NCI-designated Comprehensive Cancer Centers in the U.S. This year’s five-year grant renewal goes a long way in acknowledging UPCI’s strength in basic, clinical, and population research, as well as education and community outreach.

UPCI investigator receives NIH supports investigative work UPCI awarded grant renewal for Outstanding Investigator Award to mitigate effects of radiation, head and neck cancer research by NCI, awarded grant to study renews Pitt grant The University of Pittsburgh researchers how food can lower cancer risk Joel S. Greenberger, MD, chair of the have received renewal of their head and neck Thomas Kensler, PhD, professor of Department of Radiation Oncology at cancer research through the National Cancer pharmacology and chemical biology and UPMC, and his team of researchers with Institute’s competitive SPORE program. co-leader for the Cancer Epidemiology the university’s Center for Medical (See page 8 for more information about and Prevention Program at UPCI, was Countermeasures Against Radiation SPORE grants.) This particular five-year presented this new award for research (CMCR) won a third grant from the National grant includes a new project to study focused on chemoprevention, or how food Institute of Allergy and Infectious Diseases differentiated thyroid cancer. Incidence of can be used to lower the risk of developing (NIAID) to continue work developing drugs this malignancy is rising at the fastest rate cancer caused by unavoidable that could provide protection from radiation of all cancers, worldwide. environmental toxins. The seven-year in emergencies such as terrorism or reactor grant is one of just 60 awarded this year. meltdowns. It is one of only four such grants awarded by the NIAID in the U.S. In the next phase of the study, researchers will be looking at ways to safely and practically administer two patented drugs to patients who may be too sick to take an oral therapy.

32 | UPMC CancerCenter UPMC CancerCenter, partner with University of Pittsburgh Cancer Institute

NONPROFIT ORG U.S. POSTAGE PAID PITTSBURGH, PA PERMIT NO. 3834 A publication of UPMC CancerCenter, partner with University of Pittsburgh Cancer Institute

UPMC Cancer Pavilion 5150 Centre Ave. Pittsburgh, PA 15232 UPMCCancerCenter.com

UPMC CancerCenter connects patients to the integrated expertise of leading clinicians, academic researchers, specialty programs, and treatment centers. By partnering with the University of Pittsburgh Cancer Institute (UPCI), designated as a Comprehensive Cancer Center by the National Cancer Institute (NCI), we are accelerating the breakthroughs in our labs into clinical practice around the world. Backed by the collective strength of UPMC and UPCI, UPMC CancerCenter is transforming cancer research, care, and prevention — one patient at a time.

For information about supporting cancer research efforts and patient care at UPMC CancerCenter and the University of Pittsburgh Cancer Institute, contact us at 412-623-4700.

CANC416277 CK/SL 5/16 © 2016 UPMC