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2019 Impact Report
2019 IMPACT REPORT Honouring Excellence. Preserving History. Inspiring Generations. We invite you to be inspired. FROM OUR BOARD CHAIR AND EXECUTIVE DIRECTOR It is an exciting time at the CMHF as we advance our mission thanks to vital and MISSION meaningful partnerships at many levels and the impacts of our programs in our 25th year of service are detailed well on the pages that follow. We are encouraged that our Recognize and celebrate capacity to do more going forward was strengthened this year with significant partner Canadian heroes whose investments: substantial operational support from the Canadian Medical Association work has advanced (CMA) for three years commencing in 2020 and program support from MD Financial health; inspire the Management across all our programs, including the Discovery Days in Health Sciences pursuit of careers in national presenting sponsorship. the health sciences. Change was also a theme for us in 2019 and it came in many forms: • After 16 years, we transitioned to temporary space at 100 Kellogg Lane in London, VISION ON in anticipation of developing our new Exhibit Hall space and offices in the North A Canada that honours Tower in 2020. This exciting, interactive destination will be home to the Children’s our medical heroes – Museum, an indoor adventure park, retail markets, a boutique hotel and an active those of the past, outdoor courtyard to name a few; an amazing co-location model that means more present and future. guests will experience the sense of pride we know comes with exploring our physical Laureate displays. • We undertook a review of our corporate identity and unveiled a new and contemporary brand, look and feel across all our programs. -
The Editors of the Journal Ofclinical Investigation Gratefully
The Editors ofThe Journal ofClinical Investigation gratefully acknowledge the assistance ofthefollowing reviewers who served during the periodfrom 1 August 1989 through 31 July 1990. Stuart Aaronson Gordon Amidon Lloyd Axelrod Daniel Beauchamp Nanette H. Paul Bormstein Francois M. Claude Amiel Ole Baadsgaard Arthur Beaudet Bishopric Gerry R. Boss Abboud Arthur J. Ammann Bernard M. Babior Daniel Bechard D. Montgomery G. F. Bottazzo Hanna E. Abboud Helmut V. Ammon Robert J. Bache Lewis C. Becker Bissell Elias H. Botvinick George Abela Athanasius Bruce R. Bacon Richard Behringer Mina J. Bissell Claude Bouchard Dana R. Anagnostou David Bader David A. Bell Peter Bitterman Richard C. Abendschein Clark L. Anderson Kamal F. Badr Graeme I. Bell Ingemar Bjorkhem Boucher J. A. Abildskov Donald C. Steinun Norman H. Bell Robert E. Black Andrew J. M. Janis Abkowitz Anderson Baekkeskov William R. Bell William G. Boulton Robert T. Abraham Jeffrey L. Anderson Jacques U. Joseph A. Bellanti Blackard Bonno N. Bouma Dale R. Robert J. Anderson Baenziger Sam Benchimol George L. Daniel Bowen- Abrahamson Sharon Anderson Grover C. Bagby Earl P. Benditt Blackburn Pope Donald I. Abrams Giuseppe Andres Marco Baggiolini William E. Benitz Perry Blackshear Laurence Boxer Christine Abrass Reubin Andres Corrado Baglioni Joel S. Bennett Paul Blake Linda Boxer Naji N. Abumrad Aubie Angel Andrew D. Baines John E. Bennett J. Edwin Blalock Aubrey E. Boyd Hugh Ackerman Harry N. Dorothy Bainton Michael Bennett Rebecca Blanton James L. Boyer Steven Ackerman Antoniades Andrew Baird Vann Bennett Roland C. Blantz Thomas Boyer Brian A. Ackrell Asok C. Antony Robert S. Balaban Neal L. Benowitz Terrence F. -
By the Numbers Excellence, Innovation, Leadership: Research at the University of Toronto a Powerful Partnership
BY THE NUMBERS EXCELLENCE, INNOVATION, LEADERSHIP: RESEARCH AT THE UNIVERSITY OF TORONTO A POWERFUL PARTNERSHIP The combination of U of T and the 10 partner hospitals affiliated with the university creates one of the world’s largest and most innovative health research forces. More than 1,900 researchers and over 4,000 graduate students and postdoctoral fellows pursue the next vital steps in every area of health research imaginable. UNIVERSITY OF TORONTO Sunnybrook Health St. Michaelʼs Sciences Centre Hospital Womenʼs College Bloorview Kids Hospital Rehab A POWERFUL PARTNERSHIP Baycrest Mount Sinai Hospital The Hospital University Health for Sick Children Network* Centre for Toronto Addiction and Rehabilitation Mental Health Institute *Composed of Toronto General, Toronto Western and Princess Margaret Hospitals 1 UNIVERSITY OF TORONTO FACULTY EXCELLENCE U of T researchers consistently win more prestigious awards than any other Canadian university. See the end of this booklet for a detailed list of awards and honours received by our faculty in the last three years. Faculty Honours (1980-2009) University of Toronto compared to awards held at other Canadian universities International American Academy of Arts & Sciences* Gairdner International Award Guggenheim Fellows National Academies** Royal Society Fellows Sloan Research Fellows American Association for the Advancement of Science* ISI Highly-Cited Researchers*** 0 20 40 60 801 00 Percentage National Steacie Prize Molson Prize Federal Granting Councilsʼ Highest Awards**** Killam Prize Steacie -
Printable List of Laureates
Laureates of the Canadian Medical Hall of Fame A E Maude Abbott MD* (1994) Connie J. Eaves PhD (2019) Albert Aguayo MD(2011) John Evans MD* (2000) Oswald Avery MD (2004) F B Ray Farquharson MD* (1998) Elizabeth Bagshaw MD* (2007) Hon. Sylvia Fedoruk MA* (2009) Sir Frederick Banting MD* (1994) William Feindel MD PhD* (2003) Henry Barnett MD* (1995) B. Brett Finlay PhD (2018) Murray Barr MD* (1998) C. Miller Fisher MD* (1998) Charles Beer PhD* (1997) James FitzGerald MD PhD* (2004) Bernard Belleau PhD* (2000) Claude Fortier MD* (1998) Philip B. Berger MD (2018) Terry Fox* (2012) Michel G. Bergeron MD (2017) Armand Frappier MD* (2012) Alan Bernstein PhD (2015) Clarke Fraser MD PhD* (2012) Charles H. Best MD PhD* (1994) Henry Friesen MD (2001) Norman Bethune MD* (1998) John Bienenstock MD (2011) G Wilfred G. Bigelow MD* (1997) William Gallie MD* (2001) Michael Bliss PhD* (2016) Jacques Genest MD* (1994) Roberta Bondar MD PhD (1998) Gustave Gingras MD* (1998) John Bradley MD* (2001) Phil Gold MD PhD (2010) Henri Breault MD* (1997) Richard G. Goldbloom MD (2017) G. Malcolm Brown PhD* (2000) Jean Gray MD (2020) John Symonds Lyon Browne MD PhD* (1994) Wilfred Grenfell MD* (1997) Alan Burton PhD* (2010) Gordon Guyatt MD (2016) C H G. Brock Chisholm MD (2019) Vladimir Hachinski MD (2018) Harvey Max Chochnov, MD PhD (2020) Antoine Hakim MD PhD (2013) Bruce Chown MD* (1995) Justice Emmett Hall* (2017) Michel Chrétien MD (2017) Judith G. Hall MD (2015) William A. Cochrane MD* (2010) Michael R. Hayden MD PhD (2017) May Cohen MD (2016) Donald O. -
CMHF Laureate Biography
Mladen Vranic, MD DSc In 1963, Dr. Mladen Vranic was invited to come to Canada by Dr. Charles H. Best, the co-discover of insulin, to be his final post-doctoral fellow. This sojourn marked the beginning of Dr. Vranic’s remarkable career as a leading advocate for the advancement of diabetes research, and teacher of innumerable renowned scientists and academic leaders. The first of Dr. Vranic’s major scientific contributions was the development of a precise tracer method that in combination with glucose clamps, measures precisely steady and non-steady state glucose turnover. Using this technique, he participated in the first clinical studies in insulin resistance and hypertriglyceridemia. From here, his brilliant career would lead to many more important contributions to medical science. Dr. Vranic pioneered physiological and molecular mechanisms whereby exercise improves, or prevents onset of type 2 diabetes. He demonstrated a new mechanism whereby the muscle is protected against hyperglycemia and therefore, against diabetic complications. This early work led to the first international symposium on exercise and diabetes that continues to have a major impact. Dr. Vranic’s discovery of extra-pancreatic glucagon revolutionized the field by changing prevailing views that a given hormone is synthesized only in a specific gland. This provided additional evidence regarding the importance of glucagon in pathogenesis of diabetes. It is a landmark for a pancreatic hormone produced at equal rates in the pancreas and elsewhere. Dr. Vranic outlined the mechanisms of decreased counterregulation of hypoglycemia on the level of the hypothalamic-pituitary-adrenal axis and pancreas, and has patented a putative new method for alleviating these defects. -
Annual Summary Corporate Plan 2010
THE GAIRDNER FOUNDATION Annual Summary Corporate Plan 2010 1 TABLE OF CONTENTS PAGE Section I About the Gairdner Foundation 4 Objectives and Achievements to Date 8 Economic Benefits 9 Section II Performance Results for 2009 Activities 10 Detailed 2009 Evaluations 11-14 Planned Activities and Anticipated Results 2010 15 Section III Financial Summary 16 Planned Receipts and Disbursements 2010 18 Section IV Risk Management 19 Section V Performance Monitoring 21 2 "Receiving the Gairdner Award is not only a tremendous honor. It is also an induction into the Gairdner family of exceptional biomedical scientists. The 50th anniversary celebration was a joyous family reunion." Gairdner (1981) and Nobel Laureate, Michael Brown, Southwestern University, Dallas 3 THE GAIRDNER FOUNDATION CORPORATE PLAN EXECUTIVE SUMMARY HISTORY The Gairdner Foundation was created in 1957 by James Arthur Gairdner to recognize and reward the achievements of medical researchers whose work contributes significantly to improving the quality of human life. Since the first awards were made in 1959, the Gairdner Awards have become Canada's foremost international award. The Canada Gairdner International Awards are one of the three most prestigious awards in medical science, along with the Swedish Nobel Prize in Medicine and the American Albert Lasker Medical Research Awards. They hold up the pinnacle of achievement as a mirror to Canadians, and in so doing, play a role in helping Canada achieve its goals of excellence. The Gairdner was incorporated in December 1957 as a charitable corporation under the laws of the Province of Ontario, Canada. Its funds originally derived from the personal gifts of the founder and members of his family. -
The Design and Validation of a Discrete-Event Simulator for Carbohydrate Metabolism in Humans
University of Wisconsin Milwaukee UWM Digital Commons Theses and Dissertations December 2020 The Design and Validation of a Discrete-Event Simulator for Carbohydrate Metabolism in Humans Husam Ghazaleh University of Wisconsin-Milwaukee Follow this and additional works at: https://dc.uwm.edu/etd Part of the Computer Sciences Commons Recommended Citation Ghazaleh, Husam, "The Design and Validation of a Discrete-Event Simulator for Carbohydrate Metabolism in Humans" (2020). Theses and Dissertations. 2505. https://dc.uwm.edu/etd/2505 This Dissertation is brought to you for free and open access by UWM Digital Commons. It has been accepted for inclusion in Theses and Dissertations by an authorized administrator of UWM Digital Commons. For more information, please contact [email protected]. THE DESIGN AND VALIDATION OF A DISCRETE-EVENT SIMULATOR FOR CARBOHYDRATE METABOLISM IN HUMANS by Husam Ghazaleh A Dissertation Submitted in Partial Fulfillment of the Requirements for the degree of Doctor of Philosophy in Engineering at The University of Wisconsin-Milwaukee Fall 2020 ABSTRACT THE DESIGN AND VALIDATION OF A DISCRETE-EVENT SIMULATOR FOR CARBOHYDRATE METABOLISM IN HUMANS by Husam Ghazaleh The University of Wisconsin-Milwaukee, 2020 Under the Supervision of Professor Mukul Goyal, Ph.D. CarbMetSim is a discrete event simulator that tracks the changes of blood glucose level of a human subject after a timed series of diet and exercises activities. CarbMetSim implements wider aspects of carbohydrate metabolism in individuals to capture the average effect of various diet/exercise routines on the blood glucose level of diabetic patients. The simulator is implemented in an object-oriented paradigm, where key organs are represented as classes in the CarbMetSim. -
EGTA, Ethyleneglycol-Bis(P-Aminoethyl Cm
Abbreviations h, hour n, number in study, group (material in parentheses Hepes, N-2-hydroxyethylpiperazine-N'-2- N, normal (concentration) for explanation only) ethane sulfonic acid NS, not significant HLA, human histocompatability No.(s), number(s) ADP, adenosine diphosphate leukocyte antigens OD, optical density AMP, adenosine monophosphate Ig, immunoglobulin osM, osmolar ATP, adenosine triphosphate IU, international unit(s) osmol, osmole(s) ACTH, adrenocorticotropin i.m., intramuscular Mosmol, microosmole(s) A, ampere(s) i.p., intrapeiitoneal mosmol, milliosmole(s) MA, microampere(s) i.v., intravenous % (with numeral), percent mA, milliampere(s) °K, degree kelvin P, probability A, angstrom (10-8 cm) kcal, kilocalorie(s) POPOP, 1,4-bis[2-(5- BCG, Calmetti-Guerin bacillus kcycle, kilocycle(s) phenyloxazolyl)]benzene BMR, basal metabolic rate kg-m, kilogram-meter(s) PPO, 2,5-diphenyloxazole 0C, degree Celsius liter(s), liter(s) RQ, respiratory quotient r, correlation coefficient Mul (not A), microliter(s) rpm, revolutions per minute cpm, counts per minute ml, milliliter(s) RNA, ribonucleic acid cps, counts per second nl, nanoliter(s) (millimicroliter) s, second(s) Ci, curie(s) pl, picoliter(s) (micromicroliter) Ms, microsecond(s) MCi, microcurie(s) m, meter(s) ms, milliseconds mCi, millicurie(s) cm, centimeter(s) s, sedimentation coefficient cycle/min, cycle(s) per minute km, kilometer(s) sp act, specific activity cycle/s, cycle(s) per second mm, millimeter(s) SD, standard deviation 2 D, dalton cm , square centimeter(s) SE, standard error -
100 Years of Biochemistry at the University of Toronto – Marian A
Bulletin The Canadian Society of Biochemistry, Molecular & Cellular Biology La Société canadienne de biochemie, de biologie moléculaire et cellulaire ISSN 1197-6578/2007 2007 www.csbmcb.ca Bulletin The Canadian Society of Biochemistry, Molecular & Cellular Biology La Société canadienne de biochemie, de biologie moléculaire et cellulaire 2007 www.csbmcb.ca 2 CSMCB/SCBBMC BULLETIN 2007 FRONT COVER IMAGES: Illustration by Martin Krzywinski, Scientist (Mapping), Canada’s Michael Smith Genome Sciences Centre CSMCB/SCBBMC BULLETIN 2007 3 Contents CSBMCB Board for 2007-2008................................................................................................4 CSBMCB President’s Report...................................................................................................5 Incoming Members of the CSBMCB Executive Board 2006-2007....................................8 Laura Frost, Vice-President; Jean-Pierre Perreault, Councillor; David Williams, Councillor Minutes of the 50th CSBMCB Annual General Meeting ..................................................12 CSBMCB/SCBBMC Financial Statement.............................................................................15 The 50th Annual Meeting of the CSBMCB.........................................................................17 Poster and travel award recipients for the 2007 CSBMCB Meeting .............................19 Scenes from the 2007 CSBMCB Meeting ............................................................................21 Program for the 51st Annual Meeting of the -
Glucoregulatory and Metabolic Response to Exercise in Obese Noninsulin-Dependent Diabetes
Glucoregulatory and metabolic response to exercise in obese noninsulin-dependent diabetes HOWARD L. MINUK, MLADEN VRANIC, ERROL B. MARLISS, AMIR K. HANNA, A. M. ALBISSER, AND BERNARD ZINMAN Departments of Medicine and Physiology, University of Toronto, Toronto, Ontario, Canada M5G 1 L7 MINUK,HOWARD L., MLADEN VRANIC,ERROL B. MARLISS, glycemia was more clearly defined. Studies in animals (4, AMIR K. HANNA, A. M. ALBISSER, AND BERNARD ZINMAN. 14) and man (15, 16, 33,39,40) have shown that exercise Glucoregulatory and metabolic response to exercise in obese following subcutaneous insulin administration may result noninsulin-dependent diabetes. Am. J. Physiol. 240 (Endocri- in hyperinsulinemia, impaired hepatic glucose production nol. Metab. 3): E4587E464, 1981.-The metabolic response to concurrent with increased utilization (14, 39), and hence exercise in obese postabsorptive noninsulin-dependent diabetics was compared to that of obese nondiabetics. Exercise consisted a decline in glycemia. The reason for hyperinsulinemia is of 45 min on a cycle ergometer at 60% maximum oxygen either increased absorption of insulin from its subcuta- consumption. Six diabetic subjects were studied during oral neous depot during exercise (4, 14, 16, 39) or increased hypoglycemic therapy and four on diet alone. The sulfonylurea levels of immunoreactive insulin (IRI) already present therapy had no effect on the response. Glycemia was elevated during the preexercise period (15). In contrast, when at rest in both diabetic subgroups (192 t 24 mg/dl for diet exercise is performed by hyperglycemic diabetics with- alone, 226 ~fr 36 mg/dl for sulfonylurea treatment) and a similar drawn from insulin, low levels of IRI are present and fall (35 and 37 mg/dl, respectively) occurred with exercise. -
Calendar 2008-2009
University of Toronto School of Graduate Studies 2008 / 2009 Calendar Graduate Programs: Web Site: Student Services at SGS: For admission and application www.sgs.utoronto.ca Telephone: (416) 978-6614 information, contact the graduate unit Fax: (416) 978-4367 directly. Contact information and Web E-mail: site addresses are listed in each unit's [email protected] entry. [email protected] 63/65 St. George Street, Toronto, Ontario, Canada, M5S 2Z9 Mission Statement Dean’s Welcome The mission of the School of Graduate Studies I am delighted to welcome you to the many graduate is to promote excellence in graduate education and communities of the University of Toronto. We are proud of research University-wide and ensure consistency and our accomplishments as a centre for graduate education high standards across the divisions. Sharing respon- that integrates advanced scholarship and research into sibility for graduate studies with graduate units and every degree program. Please use this site to learn more divisions, and operating through a system of collegial about the excellent programs we offer. governance, consultation and decanal leadership, Here at the largest graduate school in Canada, over SGS defines and administers university-wide regula- 13,000 graduate students are studying in an extraordi- tions for graduate education. nary range of scholarly fields. The diversity of our depart- SGS also provides expertise, advice and information; ments, centres, and institutes means that the focus and oversees the design and delivery of programs; organizes expertise that you seek is very likely to be found within reviews and develops performance standards; supports the graduate offerings at U of T. -
2006-2007 Annual Report
2007 annual report 1 April 06 - 31 March 07 the future is in our genes. Chairman’s Message 02 President’s Message 04 OGI’s Mission 06 Research Programs Genetic Basis of Human Health 08 Biomarkers 12 Infectious Diseases and Promoting Global Health 14 Biodiversity, the Environment and Looking Ahead 16 Research Programs 18 Business Development Investments 20 Science - Industry Workshops 22 Outreach Public Outreach and Next Generation Innovators 24 Reaching Out Through The Arts 26 Workshops and Talks 28 Operations Board of Directors and Staff 29 Financial Snapshot 30 Financial Statements (inserted into flap at back) Copyright 2007 Ontario Genomics Institute 2007 annual report • 01 Chairman’s Message As Chair of the Ontario Genomics Institute (OGI), I am teomics research and to the growing cadre of internation- proud to report that the past year was for OGI a very posi- ally-recognized scientific researchers in this province whose tive reflection of our goal of augmenting -- through our knowledge and technical prowess are driving leading-edge focus on the genomics sector -- Ontario’s role as a pre- genomics research that will, in the long run, benefit all eminent centre in the life sciences industry. Now entering Canadians and help sustain and improve us economically. its seventh year, OGI continues to realize the benefits of sound strategic thinking, a clear direction, broad and fruit- Other partnerships have also been crucial. As always, the ful strategic partnerships, excellent recruitment and the partnerships with the various universities, research hospitals strong support of its major stakeholders. and other life science research institutions in Ontario (and beyond) has been of paramount importance.