PRODUCT DATA SHEET Bioworld Technology,Inc.

ZNF408 polyclonal antibody

Catalog: BS71268 Host: Rabbit Reactivity: Human,Mouse,Rat

BackGround: by affinity-chromatography using epitope-specific im- Zinc-finger contain DNA-binding domains and munogen and the purity is > 95% (by SDS-PAGE). have a wide variety of functions, most of which encom- Applications: pass some form of transcriptional activation or repression. WB 1:500 - 1:2000 The majority of zinc-finger proteins contain a Krüp- IHC 1:50 - 1:200 pel-type DNA binding domain and a KRAB domain, Storage&Stability: which is thought to interact with KAP1, thereby recruit- Store at 4°C short term. Aliquot and store at -20°C long ing histone modifying proteins. As a member of the term. Avoid freeze-thaw cycles. Krüppel C2H2-type zinc-finger family, ZNF396 Specificity: (zinc finger protein 396), also known as PRDM17 (PR ZNF408 polyclonal antibody detects endogenous levels domain zinc finger protein 17), is a 720 amino acid nu- of ZNF408 protein. clear protein that contains 10 C2H2-type zinc fingers. The DATA: encoding ZNF408 maps to human 11, which houses over 1,400 and comprises nearly 4% of the . Jervell and Lange-Nielsen syn- drome, Jacobsen syndrome, Niemann-Pick disease, he- reditary angioedema and Smith-Lemli-Opitz syndrome are associated with defects in genes that maps to chro- mosome 11. Product: Western blot analysis of extracts of various cells, using ZNF408 anti- Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, body. 50% glycerol, pH7.2 Note: Molecular Weight: For research use only, not for use in diagnostic procedure. ~ 78 kDa Swiss-Prot: Q9H9D4 Purification&Purity: The antibody was affinity-purified from rabbit antiserum

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