PDF Output of CLIC (Clustering by Inferred Co-Expression)
Total Page:16
File Type:pdf, Size:1020Kb
PDF Output of CLIC (clustering by inferred co-expression) Dataset: Num of genes in input gene set: 8 Total number of genes: 16493 CLIC PDF output has three sections: 1) Overview of Co-Expression Modules (CEMs) Heatmap shows pairwise correlations between all genes in the input query gene set. Red lines shows the partition of input genes into CEMs, ordered by CEM strength. Each row shows one gene, and the brightness of squares indicates its correlations with other genes. Gene symbols are shown at left side and on the top of the heatmap. 2) Details of each CEM and its expansion CEM+ Top panel shows the posterior selection probability (dataset weights) for top GEO series datasets. Bottom panel shows the CEM genes (blue rows) as well as expanded CEM+ genes (green rows). Each column is one GEO series dataset, sorted by their posterior probability of being selected. The brightness of squares indicates the gene's correlations with CEM genes in the corresponding dataset. CEM+ includes genes that co-express with CEM genes in high-weight datasets, measured by LLR score. 3) Details of each GEO series dataset and its expression profile: Top panel shows the detailed information (e.g. title, summary) for the GEO series dataset. Bottom panel shows the background distribution and the expression profile for CEM genes in this dataset. Overview of Co-Expression Modules (CEMs) with Dataset Weighting Scale of average Pearson correlations Num of Genes in Query Geneset: 8. Num of CEMs: 1. 0.0 0.2 0.4 0.6 0.8 1.0 Nefl Nefh Ina Prph Dlgap2 Nrp1 Ldlrap1 Gan Nefl Nefh Ina CEM 1 (128 datasets) Prph Dlgap2 Nrp1 Ldlrap1 Singletons Gan 2900011O08Rik Symbol Num ofCEMGenes:5.Predicted466.SelectedDatasets:128.Strength:0.9 CEM 1,Geneset"[G]neurofilament",Page1 Tmem130 Zfp804a Arhgef7 Slc6a15 Slc7a14 Mapk10 Snap25 Spock3 Snap91 Resp18 Sult4a1 Pcsk1n Ctnna2 Dlgap2 Nap1l2 Tagln3 Crmp1 Gdap1 Stmn3 Stmn2 Cadps Unc80 Tubb3 Elavl3 Elavl4 Elavl2 Gpr22 Nrsn1 Disp2 Cplx1 Grm7 Myt1l Gng3 Add2 Napb Nefm Hpca Scg5 Scg3 Vat1l Jph3 Prph Rtn1 Nefh Bai3 Syt4 Nefl Syp Ina 0.0 1.0 GSE45487 [9] GSE9441 [36] GSE12499 [10] Only showingfirst200datasets-Seetxtoutputforfulldetails. GSE56236 [12] GSE33770 [8] GSE17797 [19] GSE40261 [8] GSE8715 [6] GSE43779 [6] GSE53951 [10] GSE35396 [24] GSE17739 [24] GSE11110 [11] GSE5128 [18] GSE24628 [16] GSE54678 [6] GSE4816 [12] GSE39621 [51] GSE30865 [68] GSE28559 [30] GSE32937 [8] GSE31004 [8] GSE48369 [36] GSE13432 [12] GSE38672 [6] GSE40286 [10] GSE17096 [20] GSE7831 [14] GSE7020 [8] GSE9338 [42] GSE38335 [9] GSE32529 [224] GSE15069 [15] GSE21193 [10] GSE20636 [35] GSE26076 [12] GSE21687 [192] GSE51213 [16] GSE6223 [13] GSE10587 [6] GSE15914 [9] GSE9566 [38] GSE51365 [28] GSE6134 [7] GSE15729 [15] GSE30138 [51] GSE11343 [19] GSE9954 [70] GSE6933 [15] GSE26822 [8] GSE1986 [17] GSE31106 [18] GSE6196 [9] GSE29458 [23] GSE11291 [60] GSE51483 [45] GSE8249 [46] GSE5296 [96] GSE24207 [73] GSE4774 [15] GSE10246 [182] GSE30863 [20] GSE49128 [17] GSE27546 [51] GSE51108 [6] GSE18597 [42] GSE10871 [32] GSE8024 [8] GSE46211 [18] GSE14012 [24] GSE51080 [18] GSE16496 [102] GSE37301 [20] GSE11165 [6] GSE38693 [8] GSE19925 [6] GSE17745 [6] GSE9977 [24] GSE19709 [168] GSE26024 [20] GSE7707 [18] GSE8434 [6] GSE54774 [12] GSE37975 [8] GSE11918 [9] GSE13149 [25] GSE43261 [38] GSE14354 [6] GSE13421 [8] GSE7809 [8] GSE16994 [12] GSE20426 [35] GSE11149 [8] GSE11400 [8] GSE18704 [9] GSE24489 [14] GSE44923 [16] GSE32020 [26] GSE14843 [6] GSE19753 [29] GSE58915 [21] GSE50123 [6] GSE21594 [12] GSE32681 [61] GSE15794 [6] GSE23081 [6] GSE41759 [14] GSE59437 [30] GSE30744 [6] GSE15760 [6] GSE45229 [20] GSE17097 [20] GSE10182 [7] GSE4928 [8] GSE8407 [17] GSE23600 [10] GSE55738 [6] GSE22291 [16] GSE53299 [6] GSE20645 [8] GSE35160 [6] GSE16585 [31] GSE31570 [6] GSE10192 [24] GSE29632 [42] GSE26616 [6] GSE27114 [6] GSE10478 [6] GSE27987 [31] GSE48397 [10] GSE8091 [16] GSE9743 [12] GSE36814 [20] GSE52118 [9] GSE30561 [6] GSE30498 [12] GSE10904 [6] GSE19793 [32] GSE11859 [27] GSE4658 [6] GSE11818 [6] GSE24614 [6] GSE11333 [6] GSE9913 [9] GSE42548 [29] GSE8488 [15] GSE25286 [10] GSE30852 [6] GSE27630 [8] GSE48811 [20] GSE15401 [18] GSE9975 [36] GSE20008 [6] GSE46443 [12] CEM+ CEM GSE28417 [12] GSE16675 [72] GSE19338 [24] GSE50122 [10] GSE8726 [7] GSE12333 [6] 0.0 GSE51422 [6] GSE41746 [18] GSE26355 [6] Scale ofaveragePearsoncorrelations GSE24276 [6] GSE41095 [6] GSE40939 [10] GSE35260 [21] GSE20260 [48] GSE17404 [9] 0.2 GSE6957 [12] GSE12772 [8] GSE47811 [12] GSE48203 [9] GSE35357 [12] GSE10806 [11] GSE26461 [6] GSE32103 [6] GSE56492 [12] 0.4 GSE3595 [6] GSE4260 [6] GSE35436 [6] GSE6275 [36] GSE14499 [26] GSE14395 [24] GSE33134 [31] GSE23923 [8] GSE52357 [8] 0.6 GSE54056 [12] GSE10965 [8] GSE45028 [22] GSE29382 [36] GSE22448 [6] GSE38797 [16] GSE9123 [8] GSE13103 [8] GSE32330 [12] 0.8 GSE11443 [6] GSE31208 [8] GSE43381 [26] GSE37431 [6] Score 54.04 54.38 54.44 54.44 54.54 54.59 54.89 55.58 56.16 56.50 56.62 56.86 58.11 58.68 58.93 60.12 60.80 63.14 63.20 63.76 64.18 64.25 65.11 66.65 67.53 68.87 68.90 70.36 71.50 78.92 79.67 84.02 86.29 86.29 87.37 91.92 96.32 97.32 102.23 105.65 106.22 110.31 111.07 123.66 165.98 1.0 Notes Symbol Num ofCEMGenes:5.Predicted466.SelectedDatasets:128.Strength:0.9 CEM 1,Geneset"[G]neurofilament",Page2 Mapk8ip2 Gm16532 Fam155a Rundc3a Zcchc12 Jakmip2 Ppp2r2c Dync1i1 Map7d2 Phactr3 Camta1 Spock1 Cyp4x1 N28178 Syngr3 Kcnip4 Pnma2 Sh3gl2 Rimkla Nap1l5 Lsamp Iqsec3 Gap43 Slitrk1 Rph3a Cend1 Stmn4 Soga3 Scn3b Ppfia2 Rims3 Lhfpl5 Scn8a Fxyd7 Ndrg4 Nrsn2 Uchl1 Vsnl1 Ttc9b Chgb Chd5 Chga Nsg2 Kif3c Syn1 Syn2 Sv2a Dner Ttc9 Vgf 0.0 1.0 GSE45487 [9] GSE9441 [36] GSE12499 [10] Only showingfirst200datasets-Seetxtoutputforfulldetails. GSE56236 [12] GSE33770 [8] GSE17797 [19] GSE40261 [8] GSE8715 [6] GSE43779 [6] GSE53951 [10] GSE35396 [24] GSE17739 [24] GSE11110 [11] GSE5128 [18] GSE24628 [16] GSE54678 [6] GSE4816 [12] GSE39621 [51] GSE30865 [68] GSE28559 [30] GSE32937 [8] GSE31004 [8] GSE48369 [36] GSE13432 [12] GSE38672 [6] GSE40286 [10] GSE17096 [20] GSE7831 [14] GSE7020 [8] GSE9338 [42] GSE38335 [9] GSE32529 [224] GSE15069 [15] GSE21193 [10] GSE20636 [35] GSE26076 [12] GSE21687 [192] GSE51213 [16] GSE6223 [13] GSE10587 [6] GSE15914 [9] GSE9566 [38] GSE51365 [28] GSE6134 [7] GSE15729 [15] GSE30138 [51] GSE11343 [19] GSE9954 [70] GSE6933 [15] GSE26822 [8] GSE1986 [17] GSE31106 [18] GSE6196 [9] GSE29458 [23] GSE11291 [60] GSE51483 [45] GSE8249 [46] GSE5296 [96] GSE24207 [73] GSE4774 [15] GSE10246 [182] GSE30863 [20] GSE49128 [17] GSE27546 [51] GSE51108 [6] GSE18597 [42] GSE10871 [32] GSE8024 [8] GSE46211 [18] GSE14012 [24] GSE51080 [18] GSE16496 [102] GSE37301 [20] GSE11165 [6] GSE38693 [8] GSE19925 [6] GSE17745 [6] GSE9977 [24] GSE19709 [168] GSE26024 [20] GSE7707 [18] GSE8434 [6] GSE54774 [12] GSE37975 [8] GSE11918 [9] GSE13149 [25] GSE43261 [38] GSE14354 [6] GSE13421 [8] GSE7809 [8] GSE16994 [12] GSE20426 [35] GSE11149 [8] GSE11400 [8] GSE18704 [9] GSE24489 [14] GSE44923 [16] GSE32020 [26] GSE14843 [6] GSE19753 [29] GSE58915 [21] GSE50123 [6] GSE21594 [12] GSE32681 [61] GSE15794 [6] GSE23081 [6] GSE41759 [14] GSE59437 [30] GSE30744 [6] GSE15760 [6] GSE45229 [20] GSE17097 [20] GSE10182 [7] GSE4928 [8] GSE8407 [17] GSE23600 [10] GSE55738 [6] GSE22291 [16] GSE53299 [6] GSE20645 [8] GSE35160 [6] GSE16585 [31] GSE31570 [6] GSE10192 [24] GSE29632 [42] GSE26616 [6] GSE27114 [6] GSE10478 [6] GSE27987 [31] GSE48397 [10] GSE8091 [16] GSE9743 [12] GSE36814 [20] GSE52118 [9] GSE30561 [6] GSE30498 [12] GSE10904 [6] GSE19793 [32] GSE11859 [27] GSE4658 [6] GSE11818 [6] GSE24614 [6] GSE11333 [6] GSE9913 [9] GSE42548 [29] GSE8488 [15] GSE25286 [10] GSE30852 [6] GSE27630 [8] GSE48811 [20] GSE15401 [18] GSE9975 [36] GSE20008 [6] GSE46443 [12] CEM+ CEM GSE28417 [12] GSE16675 [72] GSE19338 [24] GSE50122 [10] GSE8726 [7] GSE12333 [6] 0.0 GSE51422 [6] GSE41746 [18] GSE26355 [6] Scale ofaveragePearsoncorrelations GSE24276 [6] GSE41095 [6] GSE40939 [10] GSE35260 [21] GSE20260 [48] GSE17404 [9] 0.2 GSE6957 [12] GSE12772 [8] GSE47811 [12] GSE48203 [9] GSE35357 [12] GSE10806 [11] GSE26461 [6] GSE32103 [6] GSE56492 [12] 0.4 GSE3595 [6] GSE4260 [6] GSE35436 [6] GSE6275 [36] GSE14499 [26] GSE14395 [24] GSE33134 [31] GSE23923 [8] GSE52357 [8] 0.6 GSE54056 [12] GSE10965 [8] GSE45028 [22] GSE29382 [36] GSE22448 [6] GSE38797 [16] GSE9123 [8] GSE13103 [8] GSE32330 [12] 0.8 GSE11443 [6] GSE31208 [8] GSE43381 [26] GSE37431 [6] Score 40.22 40.46 40.58 40.89 40.96 41.19 41.19 41.20 41.27 41.40 41.72 41.93 42.11 42.48 43.32 43.32 43.52 43.57 43.64 43.77 44.01 44.33 44.99 45.05 45.06 45.31 46.32 46.57 47.43 47.94 47.98 48.61 48.80 48.92 49.33 49.43 49.73 49.83 50.01 50.80 51.00 51.32 51.34 51.63 52.67 53.05 53.12 53.19 53.89 53.97 1.0 Notes 3110047P20Rik Symbol Num ofCEMGenes:5.Predicted466.SelectedDatasets:128.Strength:0.9 CEM 1,Geneset"[G]neurofilament",Page3 Tmem179 Ankrd34b AI593442 Tmem59l Cacna1b Zcchc18 Pacsin1 Slc17a6 Dusp26 Unc13a Rab33a Tubb4a St8sia3 Chrna7 Cadm2 Hpcal4 Vstm2l Dpysl5 Sez6l2 Lonrf2 Celsr3 Dpp10 Pgbd5 Rab6b Rab9b Rims1 Panx2 Fbxo2 Prmt8 Amph Car10 Astn1 Stx1b Fgf12 Gria2 Lrfn5 Eno2 Ache Rgs7 Celf6 Sncg Scg2 Nrg3 Clgn Syt9 Klc1 Lgi1 Tub Vip 0.0 1.0 GSE45487 [9] GSE9441 [36] GSE12499 [10] Only showingfirst200datasets-Seetxtoutputforfulldetails. GSE56236 [12] GSE33770 [8] GSE17797 [19] GSE40261 [8] GSE8715 [6] GSE43779 [6] GSE53951 [10] GSE35396 [24] GSE17739 [24] GSE11110 [11] GSE5128 [18] GSE24628 [16] GSE54678 [6] GSE4816 [12] GSE39621 [51] GSE30865 [68] GSE28559 [30] GSE32937 [8] GSE31004 [8] GSE48369 [36] GSE13432 [12] GSE38672 [6] GSE40286 [10] GSE17096 [20] GSE7831