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Multiple Factor Binding Sites Predict AID Targeting in Non-Ig Jamie L. Duke, Man Liu, Gur Yaari, Ashraf M. Khalil, Mary M. Tomayko, Mark J. Shlomchik, David G. Schatz and This information is current as Steven H. Kleinstein of September 26, 2021. J Immunol published online 20 March 2013 http://www.jimmunol.org/content/early/2013/03/20/jimmun ol.1202547 Downloaded from

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The Journal of Immunology is published twice each month by The American Association of Immunologists, Inc., 1451 Rockville Pike, Suite 650, Rockville, MD 20852 Copyright © 2013 by The American Association of Immunologists, Inc. All rights reserved. Print ISSN: 0022-1767 Online ISSN: 1550-6606. Published March 20, 2013, doi:10.4049/jimmunol.1202547 The Journal of Immunology

Multiple Binding Sites Predict AID Targeting in Non-Ig Genes

Jamie L. Duke,* Man Liu,†,1 Gur Yaari,‡ Ashraf M. Khalil,x Mary M. Tomayko,{ Mark J. Shlomchik,†,x David G. Schatz,†,‖ and Steven H. Kleinstein*,‡

Aberrant targeting of the activation-induced cytidine deaminase (AID) results in the accumulation of somatic in ∼25% of expressed genes in germinal center B cells. Observations in Ung2/2 Msh22/2 mice suggest that many other genes efficiently repair AID-induced lesions, so that up to 45% of genes may actually be targeted by AID. It is important to understand the mechanisms that recruit AID to certain genes, because this mistargeting represents an important risk for genome instability. We hypothesize that several mechanisms combine to target AID to each . To resolve which mechanisms affect AID targeting, we analyzed 7.3 Mb of sequence data, along with the regulatory context, from 83 genes in Ung2/2 Msh22/2 mice to identify

common properties of AID targets. This analysis identifies three transcription factor binding sites (E-box motifs, along with YY1 Downloaded from and C/EBP-b binding sites) that may work together to recruit AID. Based on previous knowledge and these newly discovered features, a classification tree model was built to predict genome-wide AID targeting. Using this predictive model, we were able to identify a set of 101 high-interest genes that are likely targets of AID. The Journal of Immunology, 2013, 190: 000–000.

omatic hypermutation (SHM) occurs in germinal center the enzyme that deaminates cytosines to initiate SHM, can act

(GC) B cells, resulting in the introduction of point muta- outside of the Ig locus. In a previous sequencing study, we showed http://www.jimmunol.org/ tions into Ig genes. Although SHM provides an important that .45% of expressed genes in GC B cells are targeted by AID in S 2/2 2/2 source of genetic diversity, capable of producing specific Abs for Ung Msh2 double-knockout (dKO) mice, where the absence quickly evolving pathogens, the process also poses a severe threat of DNA repair reveals the “footprint” of AID. Even among genes to genomic stability. Activation-induced cytidine deaminase (AID), that were targeted by AID, this study revealed a wide range of frequencies observed across 83 genes (1). In this study, we seek to address two basic questions that are raised by the former *Interdepartmental Program in Computational Biology and , Yale study: Why are some genes targeted by AID, whereas others are University, New Haven, CT 06511; †Department of Immunobiology, Yale University ‡ not? and How do the genes targeted by AID accumulate different

School of Medicine, New Haven, CT 06510; Department of Pathology, Yale Uni- by guest on September 26, 2021 versity School of Medicine, New Haven, CT 06510; xDepartment of Laboratory levels of mutation? The main hypothesis we pursue is that sequence Medicine, Yale University School of Medicine, New Haven, CT 06510; {Department features of each are responsible for this differential targeting. of Dermatology, Yale University School of Medicine, New Haven, CT 06510; and ‖ The current model of SHM proposes two phases (2). In the first Howard Hughes Medical Institute, New Haven, CT 06510 1 phase, AID converts a cytosine (C) residue to a uracil (U) in ssDNA Current address: Drinker Biddle & Reath LLP, Washington, D.C. created during the process of transcription, which, if left unrepaired, Received for publication September 26, 2012. Accepted for publication February 15, leads to a C to T (thymine) transition mutation when the DNA is 2013. replicated for cell division (3). The second phase of SHM begins J.L.D. was supported in part by the Pharmaceutical Research and Manufacturers of America Foundation and National Institutes of Health Grant T15 LM07056 from the when DNA repair mechanisms attempt to remove the uracil lesion National Library of Medicine. D.G.S. is an investigator of the Howard Hughes from the DNA. The repair of the uracil happens via two pathways: Medical Institute. Computational resources were provided by the Yale University base excision repair with UNG and mismatch repair facilitated by Biomedical High Performance Computing Center (National Institutes of Health Grant RR19895). the MSH2/MSH6 complex, both of which are capable of working J.L.D. and S.H.K. designed the analyses; M.L. and D.G.S. designed the RNA poly- in an error-prone fashion and contributing to the observed muta- merase II ChIP-Seq experiment; M.L. performed the ChIP portion of the experiment; tion frequency (4). In the dKO setting, the second phase of SHM M.M.T. and M.J.S. provided the microarray expression data; J.L.D. and G.Y. wrote is unavailable, thus revealing the underlying “footprint” of AID, software for the analyses; J.L.D. performed the analyses; and J.L.D., D.G.S., and S.H.K. wrote the manuscript. All authors commented on the manuscript. where the expectation is primarily C → T transition mutations. We The microarray data presented in this article have been submitted to the Gene Ex- previously sequenced 83 non-Ig genes from dKO mice on average pression Omnibus (http://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE44260) 70 times per gene over a 1-kb region downstream of the tran- under accession number GSE44260. scription start site (TSS) (1). Mutation frequencies varied widely, Address correspondence and reprint requests to Dr. Steven H. Kleinstein, Yale Uni- ranging from ,1 3 1025 to 116.1 3 1025 mutations/bp, but they versity School of Medicine, 300 George Street, Suite 505, New Haven, CT 06511. E-mail address: [email protected] were highly predictable for the same gene across samples from The online version of this article contains supplemental material. multiple mice. In the same system, sequencing of an IgH positive control, specifically the VhJ558-Jh4 intron 39 flanking region Abbreviations used in this article: AID, activation-induced cytidine deaminase; ChIP, chromatin immunoprecipitation; ChIP-Seq, chromatin immunoprecipitation followed (hereafter referred to as the Jh4 intron), found a mutation frequency by massively parallel sequencing; CSR, class switch recombination; dKO, double of 9.96 3 1023 mutations/bp. Each gene represents a unique ge- knockout; FDR, false-discovery rate; GC, germinal center; GSEA, gene set enrich- ment analysis; KO, knockout; KW, Kruskal–Wallis test; MWU, Mann–Whitney U nomic context in which to explore the various properties associated test; NB, negative binomial; RefSeq, National Center for Biotechnology Information with AID targeting. Reference Sequence; SHM, somatic hypermutation; TC-Seq, translocation-capture Differential AID activity in non-Ig genes may be influenced by sequencing; TSS, transcription start site; ZI-NB, zero-inflated negative binomial. multiple underlying mechanisms. A higher transcription rate may Copyright Ó 2013 by The American Association of Immunologists, Inc. 0022-1767/13/$16.00 be associated with an increased mutation frequency. Genes with

www.jimmunol.org/cgi/doi/10.4049/jimmunol.1202547 2 AID TARGETING IN NON-Ig GENES a higher mutation frequency may contain a large number of AID Dynabeads A (Invitrogen) were incubated with RNA polymerase hotspots, such as WRC (W = A/T; R = A/G), and/or few AID II Ab N20 (Santa Cruz Biotechnologies) or normal rabbit serum. Excess Ab coldspots, such as SYC (S = C/G; Y = C/T), where the C is the was washed away. Then Ab-bound beads were incubated with chromatin from 20 million sorted spleen GC B cells (previously cross-linked with 1% mutated position (5, 6). Clonal recruitment of AID to certain HCHO and then sonicated to shear the DNA fragments to 100–300 bp) at 4˚C genes may lead to an increased mutation frequency (7). Finally, overnight. Beads were washed, chromatin was eluted, and the cross-linking the genes for which high mutation frequencies are observed may was reversed. DNA was purified, precipitated, and redissolved in TE buffer. share functional elements, like transcription factor binding sites, Precipitated DNA was quantified using a PicoGreen dsDNA quantification kit (Molecular Probe). A total of 200 ng chromatin immunoprecipitation which recruit AID to the locus for mutation. In this study, we first (ChIP) DNA (from 40 million cells) ends was repaired using polynucleotide examine each of the possible mechanisms independently and then and Klenow enzyme, followed by treatment with Taq polymerase to develop an integrated model to predict targeting of AID in the generate a protruding 39 A base used for adaptor ligation. Following ligation non-Ig genes. of a pair of Solexa adaptors to the repaired ends, the ChIP DNA was am- plified using the adaptor primers for 17 cycles, and the fragments around 220 bp (mononucleosome + adaptors) were isolated from agarose gel. The Materials and Methods purified DNA was used directly for cluster generation and sequencing anal- Stratification of dKO genes ysis using the Solexa 1G Genome Analyzer, following the manufacturer’s Genes were selected for sequencing in our previous study based on multiple protocols. criteria (1): expression of the gene determined through microarray studies The resulting 25-bp reads were aligned against the mouse genome (mm8) in both mouse and B cells (8–11), because it is expected that using Efficient Local Alignment of Nucleotide Data (Illumina), allowing up expressed genes are undergoing transcription, a requirement for AID tar- to two mismatches against the reference. The reads kept for further analysis geting (3, 12); a well-defined TSS and chromosomal location; and a high had to map uniquely to the genome, and a maximum of three copies of the level of between the mouse and human genes for the first . same read was kept to reduce PCR artifact. The reads were then converted Downloaded from Genes known to be involved in the immune response, tumorigenesis, cell to browser extensible data format. The TSSs for all genes were identified proliferation, or or known to undergo chromosomal trans- using the RefSeq identifier (16) and were obtained through the UCSC locations or deletions, especially in B cell tumors, were given preference. Genome Table Browser (18) for the mouse mm8 genome build. For each Finally, the set of genes chosen was also selected to provide good coverage group, genes were aligned by the TSS, and the maximum peak of over- across the set of mouse . A total of 83 non-Ig genes was lapping reads was determined for each gene in the region 100 bases around sequenced from Peyer’s patches of Ung2/2 Msh22/2 dKO mice, in ad- the TSS. Differences among the three groups were determined using the Kruskal–Wallis test (KW), and the Mann–Whitney U test (MWU) was dition to the positive control of the Ig Jh4 intron. Each gene was se- http://www.jimmunol.org/ quenced, as previously described, in a 1-kb region directly downstream of used for determining differences among pairs of groups. the TSS (1). Mutations were determined through use of the neighborhood Mutability quality standard algorithm (13), using previously defined criteria (1). The resulting mutation frequency of each gene in the dKO setting was com- Mutations and all positions sequenced that occurred at C on either the top or pared with the background mutation rate determined by sequencing 31 bottom strands were considered for analysis if the residue and the two genes from Aicda2/2 knockout (KO) mice using the Fisher exact test. residues directly upstream passed the neighborhood quality standard criteria False-discovery rate (FDR) q-values were determined for each gene (l =0) of Liu et al. (1). Both mutations and positions that did not meet this cri- and used as the basis for ranking the genes and determining group terion were excluded from the analysis, resulting in an observed mutation assignments: group A = q-value , 1026; group B = 1026 # q-value , 1022; frequency for each gene that is slightly different from the previously and group C = q-value $ 1022. published figures. Mutability was calculated in a manner similar to that of Shapiro et al. (19), restricted to the case when the mutation is a C residue by guest on September 26, 2021 Gene-expression analysis in the third position (or G in the first position for the reverse complement). BALB/c background mice carrying IgH-transgenic alleles and targeted To do so, the frequency of mutations in each of the 16 possible dinu- cleotides upstream of the mutated C residue was tabulated for each se- deletions of the endogenous JH locus (VH186.2-Tg JH KO and V23-Tg JH quence and normalized by the total number of mutations in that sequence. KO) were immunized i.p. with 50 mgNP25- g globulin precipitated in alum, as described (9). Fourteen days later, splenocytes were isolated The same was done for all sequenced C residues to determine the back- and stained with fluorescently labeled peanut agglutinin (Vector Labora- ground. The mutability for each sequence was calculated by dividing by tories), anti-l (goat polyclonal; SouthernBiotech), and anti-CD45R/B220 the normalized frequency of the dinucleotide motifs for the mutated res- (RA3-6B2) to identify l+ PNA+ B220+ GC B cells. Cells were purified on idues by the background of the sequenced region. The overall mutability a FACSAria cell sorter (BD), as previously described (14). Live/dead for a set of sequences was calculated as the mean mutability in individual discrimination was accomplished based on forward/side scatter and pro- sequences weighted by the total number of mutations in each sequence. pidium iodide exclusion. Cells were kept at 4˚C in buffers containing Error bars were calculated by bootstrapping the original set of sequences 0.05% sodium azide to minimize alterations in . All animal 10,000 times. The p values were calculated for each motif by comparing immunizations and experiments were approved by the Yale Institutional the bootstrapped mutability values and the observed mutability values for Animal Care and Use Committee. each sample. An aggregated p value for all motifs was computed using the The mRNA expression levels among sorted cells were determined using Fisher method for combining p values of individual tests. Affymetrix Mouse 430 2.0 microarray and previously described methods Hot/cold-spot analysis (14, 15). Annotation files were obtained directly from Affymetrix (v. 31) and were used to associate the gene symbols and National Center for For each gene, the region sequenced was analyzed for occurrences of the Biotechnology Information Reference Sequence (RefSeq) (16) identifiers AID hotspot WRC and the AID coldspot SYC on both the top and bottom with each probe set. The samples were normalized using GC Robust Multi- strands. The total number of hotspots found in the sequenced region was array Average algorithm. The average expression value reported for each normalized by the number of C and G residues in the sequence to account gene was determined by taking the log2 of the average expression values for the unique composition of each gene. across all probes associated with each RefSeq identifier for all samples. These microarray data are available through the Gene Expression Omni- Negative binomial analysis bus: http://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE44260. The number of mutations from each sequence was determined for each of Polymerase II chromatin immunoprecipitation followed by the 15 genes in group A and for the Jh4 intron. The negative binomial (NB) distribution was fit to each gene using the fitdistr method available through massively parallel sequencing the MASS package for R (20), and a x2 goodness-of-fit test was applied. In Mice carrying an mVH186.2-Tg IgH Tg allele and targeted deletions of the cases in which the NB did not fit the data (p , 0.05), a zero-inflated the JH locus (17) were immunized with NP -chicken g globulin, and NB (ZI-NB) distribution was fit as defined through the emdbook package 25 2 spleens were removed 12 d postimmunization. B cells were enriched by an for R (21) and tested using a x goodness-of-fit test. EasySep customized B cell negative selection kit (without anti-CD43 Determining transcription factor binding sites Ab; Stem Cell Technologies). Cells were stained with anti-mouse B220– Cy-Chrome, anti-mouse CD19-PE, and anti-mouse GL7-FITC (all from The region 2 kb around the TSS for each sequenced gene was calculated Becton Dickinson Biosciences) Abs and sorted on a DakoCytomation based on RefSeq gene definitions (accessed July 2009). The corresponding MoFlo cell sorter at the Yale Immunobiology Cell Sorting Facility. aligned sequences for both mouse (mm9) and human (hg18) were obtained The Journal of Immunology 3 from the multiple sequence alignment, multiz30way (22), for the mouse exception of the following parameters: the minimum number of samples genome available from the UCSC Genome Bioinformatics Site (23). Re- in each node to allow a split was set to 9, the splitting index used was petitive sequences were masked from both the mouse and human se- “information,” and the loss matrix used was: quences using RepeatMasker (24). With regard to the identification of E- 2 3 box core sequences, two consensus sequences defined the site: CASSTG 0315 (where S = C or G) and CANNTG (where n = A, C, G or T). In addition, 4 10 0 10 5; the MATCH (25) program was used to scan the sequences for hits of 20 1 0 TRANSFAC-defined binding sites (26) (including all high-quality verte- where the columns correspond to the true group A, B, or C and the rows brate binding sites used for v. 2010.3) using the cutoff values defining a hit correspond to predicting group A, B, or C. Thus, a gene from group B to minimize the sum of false positives and false negatives. Only hits that predicted to be in group A results in a loss (or penalty) for misclassi- occurred in the same position in the mouse and human aligned sequences fication of 10. Ten-fold cross-validation was performed during the were retained for analysis. Note that this step of evolutionary conservation construction of the model and used to prune the full tree by choosing the does not impose upon the model an assumption that mutation spectrum tree that minimized the cross-validated error to create the final model from AID targeting in the species used for the conservation will correlate (31). perfectly, or at all, with mouse. Gene set enrichment analysis Results Gene set enrichment analysis (GSEA) was performed using the GSEA Mutation frequency is correlated weakly with transcription Preranked tool with classic weighting within the GSEA tool (27). Genes from the dKO setting were ranked according to the FDR q-value, comparing Transcription is required for SHM at the Ig locus, and we previously the dKO mutation frequency with the background mutation frequency from observed that nontranscribed genes did not accumulate mutations Liu et al. (1). A total of 10,000 permutations was used to determine the null distribution of enrichment scores for each gene set and to calculate the in the genome-wide setting (1). We asked whether, for expressed Downloaded from p value. The FDR q-value corrects for multiple hypothesis testing and is genes, there is a correlation with mutation frequency. We pre- influenced by the total number of gene sets tested. In the case of E-boxes and viously determined the mutation frequency for 83 non-Ig genes YY1 sites, the total number of gene sets tested was 6; in the general test isolated from Ung2/2 Msh22/2 dKO Peyer’s patch B cells and of all other transcription factor binding sites (including C/EBP-b), the total classified these into three groups: A, B, and C (1) (see Materials number of gene sets tested was 705. and Methods). In this setting, group A genes had the highest

Location analysis mutation frequency, percentage of C → T transition mutations, http://www.jimmunol.org/ Binding site locations were compared between sets of genes using a Bon- and hotspot focusing, followed by genes in groups B and C, with ferroni-corrected one-tailed MWU. For each gene, the binding site closest to decreases in each subsequent group, respectively. The relative the TSS (in the region 6 7.5 kb) was selected for analysis. Two sets of mRNA expression of these genes was compared in GC B cells; we control genes were included. The first set of control genes was defined as found a minimal correlation between a gene’s log mRNA ex- the top 10% of genes with the highest average expression (across all probe 2 sets and samples) in the GC B cell microarray data previously described. pression level, as measured by Affymetrix microarray, and its The second set of control genes included the set of 17 nonexpressed genes mutation frequency (r = +0.079) (Supplemental Fig. 1A). When that was sequenced in the wild-type setting (1). genes were grouped based on their p value for AID targeting (group A and B genes accumulate mutations that are significantly

Colocation and trilocation analysis by guest on September 26, 2021 different from the background and show strong signs of AID tar- For the pair-wise analysis of transcription factor binding site locations geting, whereas genes in group C are minimally mutated compared performed, a score was computed for each possible pair of binding sites with the background), we observed a positive trend between av- between two transcription factors (Eq. 1), erage log2 expression and mutation frequency (Fig. 1A). However, Colocation score5dðSÞ 1 dðTÞ; ð1Þ there is not a significant difference between these groups (p = where d(S) is the distance between the binding sites for each factor, and 0.064, KW). Thus, although AID-targeted genes seem to have d(T) is the distance of the binding site furthest from the TSS. Genes higher average log2 mRNA expression at the group level, this was without a predicted binding site in the analyzed region defined were not statistically significant, and the correlation between mutation assigned a distance equal to the maximal distance from the TSS. The genes and steady-state transcript levels is very weak. were again split into groups A, B, and C and compared against the two sets of control genes from above. In computing the trilocation score of three Because steady-state mRNA levels are not a direct measure of factors, d(S) was defined as the maximal distance between all three sites. A the rate of transcription and performing a nuclear run-on assay Bonferroni-corrected one-tailed MWU was used to determine the differ- would be difficult with GC B cells (32), RNA polymerase II ChIP ences between the groups of genes and the control sets. followed by massively parallel sequencing (ChIP-Seq) was per- formed on GC B cells to better address the relationship between Estimation of variable importance transcription rate and mutation frequency. For each gene, tran- To determine the significance of the variables that were used in this analysis, scription was quantified by the maximum peak of overlapping the measurements were obtained for all group A, B, and C genes for all polymerase II tags in the region 100 bp around the TSS. A statis- independent attributes measured across all genes. In addition, the total number of binding sites for each significant factor within the region 2 kb tically significant difference was found among the genes in groups around the TSS was included for analysis. The cforest algorithm (28) A, B, and C (p = 0.04, KW), indicating an unequal distribution of (available through the party package for R) was used to generate a random polymerase II (Fig. 1B). A further examination of the polymerase II forest of classification trees to determine the variable importance using levels among the groups revealed that group A had a significantly an unbiased approach. A forest of 1000 trees was built with the following higher amount of polymerase II compared with both group B parameters specified: minimum samples in a node for splitting = 15, 24 minimum number of samples in a leaf = 5, and number of variables ran- (p = 0.0045, MWU) and group C (p =4.63 10 ). As a control, domly selected at each node = 5. Variable importance was calculated from group A, B, and C genes all had significantly higher polymerase II the random forest, defined by the mean decrease in prediction accuracy levels compared with the set of 17 nonexpressed genes that were when values are permuted for each variable. Important variables were de- also analyzed in the previous study (1) (p values: group A = 8.2 3 fined as having a variable importance score greater than the absolute value 27 3 25 3 24 of the least important variable (29). 10 ; group B = 9.0 10 ;groupC=5.1 10 , MWU). Thus, AID targeting is correlated positively with higher levels of poly- Classification tree model to predict genome-wide SHM merase II near the TSS of a gene. However, as with mRNA ex- The classification tree model was generated using the rpart package for R pression, polymerase II levels are only weakly predictive of mutation (30). The model was constructed using the default parameters, with the frequency at the individual gene level (Fig. 1C). 4 AID TARGETING IN NON-Ig GENES

FIGURE 1. Transcription is correlated weakly with mutation frequency. (A) Normalized mRNA expression levels (averaged over all probe sets and B

microarray samples) for genes in groups A, B, and C. A set of 17 nonexpressed genes (NE) is included as a control. ( ) The maximum peak for RNA Downloaded from polymerase II binding based on ChIP-Seq of GC B cells for each group of genes, including the control of nonexpressed genes (NE). (C) Comparison of the maximum peak of RNA polymerase II and the observed mutation frequency for the 83 individual genes sequenced in the dKO setting.

Increased AID hotspot density does not lead to higher mutation random targeting (Fig. 2A). In addition, inspection of the boot- frequency strap interval for the mutability of each motif shows a high over-

AID preferentially targets WRC/GYW motifs, so it is possible that lap between the two datasets. Thus, we conclude that AID displays http://www.jimmunol.org/ genes with more of these motifs may accumulate a greater number a range of hot/cold-spot preferences in the genome-wide setting of mutations independent of AID recruitment to the locus. To test that is consistent with those at the Ig locus. this hypothesis, we first confirmed that the hot/cold-spot targeting To test whether differences in the mutability of each gene could of AID, which was previously defined at the Ig locus, was con- account for differential mutation accumulation, we compared the served in the genome-wide setting. It was shown previously that hot-/coldspot densities to the mutation frequency across the set the observed mutations, especially in the group A genes, were of 83 genes from the dKO setting. Supplemental Fig. 1B shows biased toward the SHM hotspot WRCY/RGYW motif (1). To a minimal negative relationship between hotspot frequency and 2 extend this analysis to cover the full spectrum of DNA motifs, mutation frequency (r = 0.16), and this was not significant when by guest on September 26, 2021 focusing on the AID hotspot, and to increase coverage across the genes were split into groups A/B/C (p = 0.33, KW) (Fig. 2B). all motifs given the relatively low number of mutations in the The AID coldspot SYC/GRS displayed a weak positive relation- genome-wide dataset, the relative mutability of each of the 16 ship with the mutation frequency (r = +0.2118, Supplemental Fig. possible dinucleotide combinations in the motif NNC/GNN was 1C), but once again this was not statistically significant (p = 0.31) calculated. Under the null hypothesis of no hot/cold-spot target- for groups A/B/C (Fig. 2C). We conclude that the density of AID ing, the mutability for each motif will be focused around a value hot-/coldspots does not account for the differential targeting of of 1. However, we observed significant deviations from this null AID to group A/B/C genes. hypothesis for both the group A genes and the positive control Jh4 intron. In each case, the same general trend is observed: trinu- Clonal recruitment of AID is not preserved in non-Ig genes cleotide motifs representing the classic hotspot WRChavea Clonal recruitment of SHM to the Ig locus was suggested based on higher mutability than random targeting, whereas those repre- transgene studies (7). According to this model, once a particular senting the classic coldspot SYC have a lower mutability than gene in a cell is targeted, the gene remains marked as accessible to

FIGURE 2. Genome-wide AID hot/cold-spots mirror the Ig locus but do not influence overall targeting. (A) The relative mutability of each DNA triplet motif ending in C based on group A genes and the Jh4 intron. The error bars represent the 95% confidence interval, as determined through bootstrapping of the original sequences. (B) Normalized WRC/GYW hotspot frequency for each group of genes. (C) Normalized SYC/GRS coldspot frequency for each group of genes. The Journal of Immunology 5

SHM in the cell’s progeny. If true, the differential ability of genes TSS (CASSTG, p = 0.0089; CANNTG, p = 0.0092, MWU). Pre- to initiate clonal recruitment could contribute to the wide range of vious studies showed that binding sites located closer to the TSS observed mutation frequencies in the genome-wide setting. We first have a higher probability of being true regulatory sites (37, 38). sought to confirm the idea of clonal recruitment at the Ig locus by These results strongly support a role for E-boxes in recruiting AID. analyzing the distribution of mutation counts in the Jh4 intronic We next tested whether YY1 binding sites were associated region. If mutation acts randomly among all of the cells in a pop- with AID targeting, because this transcription factor was recently ulation, the number of mutations per sequence should fit an NB shown to be a regulator of the GC gene-expression program (39). distribution (33, 34). In contrast, the process of clonal recruitment Four separate definitions exist for a YY1 binding site in the implies that only some of the cells will accumulate mutations TRANSFAC database, where each defined YY1 binding site has efficiently, whereas others that fail to recruit AID will not accu- a different length and slightly different consensus motif. Two of mulate mutations at all. In this case, we propose that the number of these four binding site definitions (YY1_Q6 and YY1_Q6_02) mutations per sequence should fit a ZI-NB distribution, which has were significantly enriched in the regions of group A the capability of modeling the distribution of the number of mu- genes (GSEA p , 0.05; FDR q-value , 0.1). Further supporting tations per sequence for cells that have recruited AID separately the involvement of YY1, these binding sites tended to be farther from those with no mutations present. Fig. 3A clearly shows that from the TSS in group C genes (Fig. 4). This shift in location was the NB distribution is a poor model for the observed mutations per significant for the YY1_Q6_02 binding site definition (p = 0.014), sequence in the Jh4 intron (p = 2.6 3 1028, x2 test), whereas the and we refer to this definition as a YY1 binding site throughout ZI-NB distribution is appropriate (p . 0.05) (35, 36). Thus, these the rest of this article. Thus, along with E-box motifs, YY1 motifs data support the idea of clonal recruitment of AID at the Ig locus. are associated with the recruitment of AID. Downloaded from In contrast, the NB distribution was an appropriate fit to all genes To identify additional transcription factors influencing AID in group A (p . 0.05) (Fig. 3, Supplemental Fig. 2). This was true targeting, we screened the remaining set of 705 high-quality ver- for both genes with a low mutation frequency, like Eif4a2 (Fig. tebrate TRANSFAC transcription factor binding sites. This analysis 3E), as well as the most mutated genes, like , Bcl6, and H2afx identified an additional factor associated with AID targeting: (Fig. 3B–D). Thus, unlike the Ig locus, we find no evidence for evolutionarily conserved binding sites for C/EBP-b (CCAAT-

clonal recruitment of AID in the genome-wide setting, and this enhancer binding protein, b), also known as NF-IL6 (p , 0.001; http://www.jimmunol.org/ process is unlikely to play a role in the differential accumulation FDR q-value = 0.094). As with both E-box and YY1 sites, the of mutations. location of C/EBP-b binding sites tends to drift away from the TSS with the decrease in mutation frequency (Fig. 4), and this is sig- E-boxes, YY1, and C/EBP-b binding sites are associated with nificant for group C genes (p = 0.0086). At no point in our analysis AID targeting did we find enrichment for binding sites inhibiting AID targeting. We previously demonstrated that evolutionarily conserved E-box Altogether, our transcription factor binding site screen and location motifs (CASSTG), which bind various E-, including E12 analysis identified three binding sites that could be involved in the and E47, were enriched in the region 2 kb around the TSS for highly recruitment of AID: E-boxes, YY1, and C/EBP-b. mutated genes (1). Extending these results, we also found moderate by guest on September 26, 2021 b enrichment for a more general form of the motif (CANNTG) Colocation of E-boxes, YY1, and C/EBP- sites in AID- (GSEA p value = 0.006; FDR q-value = 0.061). This association targeted genes between E-box motifs and highly mutated genes is further supported Because we showed that evolutionarily conserved binding sites for by a shift in the location of the motif in group A genes toward the E-boxes, YY1, and C/EBP-b have a nonrandom location distri-

FIGURE 3. AID is clonally recruited to the Ig locus but not to non-Ig genes. (A) The frequency distribution of the total number of mutations per Jh4 intron sequence was fit to both the NB (s) and the ZI-NB (n). A similar analysis was carried out for group A genes, including Myc (B), Bcl6 (C), H2afx (D), and Eif4a2 (E). 6 AID TARGETING IN NON-Ig GENES

FIGURE 4. E-box, YY1, and C/EBP-b binding sites exhibit a nonrandom location distribution with respect to the TSS of group A genes. Each gene is represented by the binding site that is closest to the TSS within the window 7.5 kb in either direction. For groups A, B and C, comparisons were made against two control groups: a set of highly expressed genes in GC B cells (HC) and a set of nonexpressed genes (NE). A statistically significant shift in bind- ing site locations is indicated by the group’s name at the top of the panel (p , 0.05, versus HC, Bon- ferroni-corrected MWU). No significant difference was detected for any group compared with the set of NE genes. bution, we set out to test whether these sites are colocated near zation of the three sites together, we developed a trilocation score one another. A colocation score was defined that combines the that incorporates the maximal distances between the three binding distance between pairs of binding sites with the distance of the sites and the location from the TSS of the gene in a manner similar

pair from the TSS of the gene, such that a low colocation score to the colocation score (see Materials and Methods). We find that Downloaded from reflects a pair of binding sites that are located close to one another both group A and group B have significantly lower trilocation scores and close to the TSS (see Materials and Methods). Using this compared with control genes (p , 0.05, Fig. 6). In addition, both scoring metric, we found that CASSTG E-box motifs were colo- groups A and B have significantly lower trilocation scores compared cated both with YY1 and C/EBP-b binding sites in group A genes with group C (p =1.73 1024 and p =9.33 1024, respectively) but at a statistically significant level compared with control genes are not distinguishable from one another (p = 0.07). These results ,

(p 0.01, Fig. 5). In addition, these two pairs of sites are sig- suggest that E-box motifs, YY1, and C/EBP-b binding sites form http://www.jimmunol.org/ nificantly colocated in group A compared with either group B a regulatory module that is capable of recruiting AID to target the genes or group C genes (p , 6.5 3 1024 and 6.0 3 1023,re- gene for mutation. spectively). Although a similar trend was observed in the colo- A combination of features can predict AID targeting genome cation scores of the CANNTG E-box with both YY1 and C/EBP-b, wide the colocation signal is much stronger for the CASSTG E-box motif. Although none of the features investigated above could individ- In addition to being colocated with E-box motifs, YY1 and ually separate genes in groups A, B, and C (note the high overlap C/EBP-b sites were found to be colocated with one another in both in box plots for each group), we hypothesized that a combination group A and B genes (Fig. 5, far right panel), and both groups have of these features could accurately predict AID targeting. As a first by guest on September 26, 2021 significantly lower colocation scores compared with group C genes step, importance analysis based on random forests was used to (p =5.73 1024 and 5.0 3 1024, respectively). Interestingly, the select a subset of variables to be included in the final model. A colocation scores from genes in groups A and B are indistin- list of variables included in this analysis is shown in Supplemental guishable from one another (p . 0.8). Because the strong colo- Fig. 3. Note that some colocation scores were excluded to reduce cation of YY1 and C/EBP-b binding sites in groups A and B can redundancy. Variable importance analysis (see Materials and distinguish genes that mutate from nonmutating genes (group C), it Methods) identified seven features as significant for separating seems that more information is required to explain the differential group A, B, and C genes: CASSTG E-box and YY1 colocation, level of mutation observed between the two groups. CASSTG E-box and C/EBP-b colocation, YY1 and C/EBP-b colocation, number of C/EBP-b sites (6 2 kb around TSS), lo- b CASSTG E-boxes, YY1, and C/EBP- sites are trilocated in cation of the C/EBP-b site closest to the TSS, and the maximum highly mutated genes polymerase II peak (6 100 bp around the TSS) (Supplemental The observation that both YY1 and C/EBP-b binding sites are Fig. 3). colocated with E-box motifs suggests that the three binding sites To predict whether each gene belongs to group A, B, or C, the may be located together, perhaps forming a cis-regulatory module seven variables identified as important were used to create a clas- located close to the TSS of the gene. To characterize the organi- sification tree. In generating this model, we strongly penalized the

FIGURE 5. E-box, YY1, and C/EBP-b binding sites are colocated in group A genes. For each pair of enriched transcription factors, the colocation score combining the distance between factors and the distance to the TSS was calculated for each gene. Groups A, B, and C were compared sepa- rately with each set of control genes (HC [highly expressed control] and NE lines at top of plot, see Fig. 4 legend). Statistically significant shifts in colocation scores are indicated above the relevant group. Single letter: p , 0.05, double letter: p , 0.01, triple letter: p , 0.001, Bonferroni-corrected MWU. The Journal of Immunology 7

that should be enriched for actual AID targets. In the first vali- dation, the set of actual AID targets was based on results from a translocation-capture sequencing (TC-Seq) study (43). This study identified 92 genes that could translocate with either IgH or Myc in an AID-dependent manner in ex vivo B cells. Of the 92 TC-Seq genes, 10 were excluded from the validation because they had been used to generate the model, 11 were not in our RefSeq database, and 1 was translocated to Myc in the AID2/2 control. Of the remaining 70 TC-Seq genes, the model predicted 19 (27%) as group A, 13 (19%) as group B, and 38 (54%) as group C (Sup- plemental Table I). When compared with the set of predictions from all mouse RefSeq-defined genes, the frequency of predicted group A and B genes was significantly higher among the TC-Seq genes than expected by chance (p = 0.00019, x2 test) (Fig. 7B). This overrepresentation of predicted group A and B genes remained FIGURE 6. E-boxes (CASSTG), C/EBP-b and YY1 binding sites tri- significant, even when the background was restricted to genes that locate in AID targets. For each gene, the trilocation score was calculated were highly expressed in GC B cells and, therefore, were more 2 by combining the distance between all three sites and the distance from the likely to accumulate AID-induced mutations (p = 0.0031, x test).

TSS. Groups A, B, and C were compared separately with each set of Overall, these results demonstrate that the classification model Downloaded from control genes (HC [highly expressed control] and NE lines at top of plot, predictions are enriched for actual AID targets. see Fig. 4 legend). Statistically significant shifts in trilocation scores are In the second validation, the set of actual AID targets was defined , indicated above the relevant group. Single letter: p 0.05, double letter: by AID binding, according to a ChIP-Seq study (44). Although the , , p 0.01, triple letter: p 0.001, Bonferroni-corrected MWU. B cells used in this study undergo class-switch recombination (CSR) and not SHM, we expect that because the two processes are

misclassification between groups A and C. The penalty for mis- linked in their use of AID we would still observe enrichment of http://www.jimmunol.org/ classification of group B genes was deemed less significant for two AID-binding genes for SHM. This assumption is supported by the reasons. First, the original classification of a gene in this group observation that group A, B, and C genes differed in the mean could change based on where the initial cut points between groups number of AID sequence tags that were bound (p = 0.013, was drawn by Liu et al. (1). Second, group B genes are still ANOVA), with the highest frequency of AID tags found in group considered to be targeted by AID, albeit at a lower level than A genes (Fig. 7C). Differential AID binding was also observed group A genes; therefore, misclassification would not be as severe among highly expressed genes that were predicted to be in groups for this middle group. The full model generated from the data was A, B, and C, with predicted group A genes exhibiting the highest pruned to an appropriate size based on the 10-fold cross-validation frequency of AID tags (p = 1.9 3 1029, ANOVA) (Fig. 7C). An error, producing a final model containing five terminal nodes with even higher frequency of AID binding was found among the 101 by guest on September 26, 2021 four decision points (Fig. 7A). For the 83 genes used to build the high-interest predicted group A genes. The significantly higher model, the overall misclassification rate was 25%, with the ma- AID binding among targets predicted by the classification model jority of these misclassified genes from group B (as expected by may be even more significant because CSR and SHM are de- the penalty setup). Importantly, the misclassification rate between pendent on different regions of the AID protein and may involve groups A and C was only 8%. It was determined through cross- process-specific cofactors that can change the targeting (3, 45), so validation that the sensitivity of the model for correctly predicting that complete overlap with the model predictions was not ex- a group A gene was 55%, with a specificity of 84% in predicting pected. Taken together, these results further support the validity of non–group A genes. Consequently, this model allows for the ac- the classification tree model to predict genome-wide targets of curate separation of genome-wide AID targets (groups A and B) AID and highlight the rationale for choosing the set of 101 high- compared with nontargeted genes (group C). interest genes put forth as candidates for experimental validation. The classification tree model was applied genome wide to predict additional AID targets. Of the 22,492 RefSeq-defined mouse genes Discussion that were not used to build the model, 3,648 (16%) were predicted The mechanisms that underlie AID targeting to the Ig locus and to be in group A, 1,949 (9%) were predicted to be in group B, and mistargeting to non-Ig loci are poorly understood. We analyzed the the remaining 16,895 (75%) were predicted to be group C (Sup- sequence context of 83 non-Ig genes that are targeted by AID to plemental Table I). To generate a list of high-quality AID targets varying degrees in dKO mice to define several mechanisms re- that would be of interest for experimental validation, predicted sponsible for genome-wide AID targeting. Our data confirm the group A genes were filtered to include only those that have an association of AID targeting with transcription and the presence of average gene expression in the top 25% of all genes in GC B cells, E-box motifs. E-boxes were found to increase the frequency of SHM as determined through mRNA expression; have human homologs in several systems (12, 46, 47). Our data also implicate several new [defined by the Mouse Genome Database (40)] annotated as either factors as relevant to the targeting of AID. In particular, YY1 and or tumor suppressors [identified by an query C/EBP-b binding sites are associated with increased mutation ac- through the CancerGenes tool (41)], or are found within the cumulation, and these sites, together with E-box motifs, are colo- COSMIC Gene Census (42) version 56. This filtering cated near the TSS of AID targets, perhaps forming a cis-regulatory produced a set of 101 high-interest genes shown in Table I. Some module. YY1 is of high interest because it is active in GC B cells notable members of this list are immune-related genes: Bcl7a, and was recently identified as a regulator for the GC program (39). Btg1, Cd82, Cdk4, Cxcr4, Foxo1, Foxp1, Irf1, Irf8, Raf1, Rela, Intriguingly, YY1 was recently shown to interact directly with Stat3, and Tcf4. AID, to influence levels of AID in the nucleus, and to enhance CSR We carried out two validations of the model by comparing the (48). C/EBP-b mRNA and protein levels were reported to increase predicted AID targets with sets of experimentally identified genes in abundance as B cells mature, and C/EBP-g, the negative regu- 8 AID TARGETING IN NON-Ig GENES Downloaded from http://www.jimmunol.org/

FIGURE 7. Classification tree model to predict genome-wide targets of AID. (A) Classification tree to predict AID targeting for individual genes. For each decision node in the tree (gray circle), the gene proceeds down the left branch if it satisfies the decision condition. The leaves of the tree indicate the predicted group (A, B, or C), along with the number of genes falling into this group from the 83 genes sequenced in the dKO setting (group A/group B/ group C). For example, genes in leaf #1 are predicted to be in group A, and this leaf has a total of nine genes from the training data: six group A genes, three group B genes, and zero group C genes. (B) AID-mediated translocated genes (43) are enriched among genes predicted by the model to be AID targets (group A) compared with the set of all genes (22,492 genes) and the set of highly expressed genes comprised of the top 25% of all genes by mRNA expression levels (4,403 genes). (C) Based on the ChIP-Seq study by Yamane et al. (44), group A and predicted group A genes show greater recruitment of

AID than do either group B or C. The mean and 95% confidence intervals of AID tags per gene are shown for each group of genes. The set of 17 by guest on September 26, 2021 nonexpressed genes is shown as a negative control. Also shown separately is the set of 101 high-interest predicted group A genes. ANOVA was used to compare the number of AID tags per gene for the group A/B/C genes used to build the model, as well as for the genes predicted by the model to be in groups A/B/C, with the p value shown above each comparison. lator of C/EBP-b, decreases with B cell maturity (49). In addition, The contribution of AID hot/cold-spots and gene transcription to a C/EBP-b site was recently identified in a mutational enhancer mutation accumulation was also evaluated. Although known AID element in the Ig L chain of DT40 cells that is conserved in the hotspots are specifically targeted in non-Ig genes (1), the frequency condor and zebra finch (50). These results support a role for shared of hotspots (or coldspots) in the sequenced region did not correlate functional elements in explaining differential AID activity in non- with the overall gene-mutation frequency. This suggests that AID Ig genes. recruitment to the locus is a rate-limiting step. Gene transcription

Table I. High-interest predicted group A genes from classification tree model

Entrez Identifier Model Leaf Genes 1 Golga5a, Lmo4, Rab18, Rab30, Rab5c, Snrpe, Ubtf 3 Actb, Fusa 4 Cblbb, Mybl1, Nae1, Pfdn5, Rapgef1, Sh3kbp1, Tpd52, Vav1 Tumor suppressor 1 Anp32b, Ccna2, Cd82, Cdk2ap2, Cdkn2cb, Cfl1, Eif2s1, Flna, Foxp1a, G3bp2, Gabarap, Gtf2e1, Ing3, Ltf, Mef2c, Nbr1, Nfkbia, Rbbp5, Tcf4, Uhrf1, Zbtb33 3 Btg2, Ddx3x, Ddx5a, Dhx9, G3bp1, Irf1, Irf8, Klf10, Tnfaip3b, Uvrag 4 Anxa7, Chfr, Foxo1, Msh2b, Ndufa13, Raf1a, Rnf129, Rnf40, Rtn4, Sdhbb, Sept9, Spint2, Stk4, Tes, Tusc2, Ywhah, Ywhaq, Zfp238 Tumor suppressor and oncogene 1 Ccdn3a, Ptenb, Rela, Rhoa 3 Ctnnb1a, Cxcr4, Hif1a, Lyn, Stat3 4 Mapk1, Prkar1aa,b, Smarcb1 Neither 1 Bcl7aa, Brd4a, Ep300a,b, Eps15a, Gnasb, Herpud1a, Ikzf1b, Lasp1a, Myh9a, Ncoa1a, Nina, Nsd1a, Thrap3a 3 Btg1a 4 Cdk4b, Chic2a, Crebbpa,b, Ncoa2a, Nfe2l2b, Numa1a, Sept6a, Sh3gl1a, Tpm3a Genes are listed according to the Entrez Query Identifier and by the leaf of the model which led to the gene being predicted as a strong AID target. aIdentified in the COSMIC database as translocation type. bIdentified in the COSMIC database as other mutation type. The Journal of Immunology 9 is also important, and some transcription is required for mutation of AID at the Ig locus, at least some features seem to be shared. accumulation in non-Ig genes, because nonexpressed genes do not Several of the transcription factors that we implicate in genome- accumulate mutations (1). Indeed, there was a small, but signifi- wide targeting have been associated with targeting at the Ig locus cant, increase in polymerase II binding among genes with the (46, 47, 53). In addition, we find that AID hot/cold-spots for highest mutation frequencies (group A). However, there was only mutation are generally shared between the Ig and non-Ig genes. a weak correlation at the level of individual genes, and highly Interestingly, there is a significant difference in the relative mu- mutated genes could be identified with widely varying levels of tability of the four individual trinucleotide motifs that form the polymerase II binding. Notably, the polymerase II–associated WRC hotspot (Fig. 2A). This may be the result of varying cofactors pause/elongation factor Spt5, a component of the DRB-sensitivity present in each unique genomic setting that slightly alters the inducing complex, interacts with AID and with Ig and non-Ig specificity of AID to its preferred nucleotide target. targets of AID (51). Although our data indicate that total poly- One significant difference found between AID targeting at Ig and merase II levels do not correlate strongly with AID targeting, non-Ig loci is the occurrence of clonal recruitment of AID. For a a better correlation might be seen upon examination of stalled random mutation process with hot-/coldspots, the distribution of the polymerase II and Spt5 in GC B cells. A recent study found that number of mutations per sequence should fit an NB distribution (33). levels of stalled polymerase II, but not Spt5, correlated with AID- Indeed, we find this model to be an appropriate fit for the non-Ig mediated mutation of an artificial mutation reporter (52). Overall, genes. In contrast, the NB is a poor fit for the Jh4 intron mutation although our analysis identifies several associations that are sta- data, because this model significantly underestimates the frequency tistically significant when comparing group A, B, and C genes, of unmutated sequences, given the mutation distribution among none of these features alone is sufficient to predict the differential sequences that do acquire mutations. Instead, these data can be fit Downloaded from accumulation of mutations by individual genes. by a ZI-NB distribution, which separately models the process of We hypothesized that several mechanisms work together to mutation accumulation from the induction of AID activity. This promote AID targeting to individual genes. By combining the suggests that these sequences from the Jh4 intron were derived features that were each associated with AID targeting, we were able from two subsets of cells: one subset in which AID had been ef- to construct a classification tree model that separated highly mu- fectively recruited to the gene being sequenced, resulting in a high

tating genes (group A) from genes that do not mutate (group C) with degree of mutation, and a second subset in which AID had not (yet) http://www.jimmunol.org/ an accuracy of 92%. It is instructive to consider the genes for which been recruited. One caveat of this analysis is that we may not ob- AID targeting is incorrectly predicted. In the training data, there are serve enough mutations in the non-Ig genes to be able to detect five genes that are considered major misclassifications: Pax5 exon whether clonal recruitment of AID is occurring, and further se- 1b, Il21r, Fas, B2m, and Mll1. For the group A genes misclassified quencing is necessary to increase the number of observed mutations as group C genes (Pax5 exon 1b, Il21r, and Fas) the lack of strong in each non-Ig gene. Overall, these results provide additional sup- evolutionary conservation between mouse and human near the TSS port for the idea that AID is clonally recruited to the Ig loci but that diminishes the ability of the model to accurately predict these clonal recruitment is not a property of genome-wide AID targeting. genes as true group A genes. Pax5 exon 1b presents unique chal- The evidence presented in this article supporting clonal re- lenges to this analysis because the sequencing was focused on an cruitment of AID to the Ig genes has potential implications with by guest on September 26, 2021 alternative promoter, which may not be adhering to the same respect to Ab diversity during the affinity-maturation process. conventions of the other genes within the group. The two group C Current thought predisposes B cells with receptors of initial high genes were predicted as group A genes for different reasons: B2m affinity to the Ag as having a competitive advantage for expansion had a high peak of polymerase II near the TSS ( peak = 20), within GCs (54). The addition of clonal recruitment may allow for and Mll1 had a conserved YY1 and E-box that had a very low the B cells with receptors of lower initial affinity, if able to recruit colocation score (score = 11), reflecting two sites that were over- AID early, to go through enough rounds of mutation, selection, and lapping and located at the TSS of the gene. Thus, many features of expansion to yield mutated receptors with equal or higher affinity each gene contribute in a small way to AID targeting. In predicting than the unmutated higher-affinity cells. These lower initial affinity, AID targets, there was not a single reason underlying false positive but early AID-recruiting, B cells could then be competitive in the and negative predictions, and improvements in accuracy are likely GC environment. Thus, depending on the time of clonal recruit- to come from the inclusion of additional features in the model. ment of AID in B cells, the expected competitive advantage of The model was applied genome wide to predict AID targets. We B cells with high-affinity receptors may be diminished enough to identified a set of 101 high-interest genes that fulfilled three cri- allow for a broader spectrum of Abs to be produced from B cells teria: they are predicted to be in group A, they are highly expressed with a wider range of initial affinities to the Ag. in GC B cells, and they have a known association with cancer. A limitation of this study is the focus on the promoter region These targets are significantly enriched for genes identified through when analyzing transcription factor binding site associations. At TC-Seq of B cells (43). They also tend to bind higher levels of AID the Ig locus, enhancer regions were shown to play a role in SHM in an ex vivo model of CSR (44). About 25% of the high-interest that is separate from influencing the rate of transcription (12, 50, genes are known to undergo translocations in oncogenic settings 55). Nevertheless, through this approach we identified three im- as identified through the Cancer Gene Census. Several of these portant DNA elements that can effectively differentiate group A genes undergo translocations with other genes known to sustain and C genes. It is likely that future work incorporating additional high levels of AID targeting: Ccnd3 translocates with IgH, Bcl7a elements in the enhancer regions will improve these predictions and Btg1 each translocate with Myc, and Foxp1 translocates with and may also distinguish group B genes, which were not a major Pax5. Additionally, two genes, Btg1 and Raf1, were previously focus of this work. However, there are still many problems to be identified as sustaining high levels of SHM in the wild-type setting worked out in the identification of enhancer boundaries and their (1) but were not sequenced in dKO mice. Thus, we have high association(s) with particular genes. confidence in the validity of our model to predict AID-induced In conclusion, we identified several mechanisms that are sig- mutations and suggest these high-interest genes as targets for fu- nificantly associated with AID targeting to non-Ig genes, including ture experiments. Although it is not clear whether a common polymerase II binding along with the presence of E-boxes, YY1, and mechanism underlies genome-wide targeting of AID and targeting C/EBP-b binding sites. A classification model integrating these 10 AID TARGETING IN NON-Ig GENES features captures ∼55% of highly targeted (group A) genes with 18. Karolchik, D., A. S. Hinrichs, T. S. Furey, K. M. Roskin, C. W. Sugnet, D. Haussler, and W. J. Kent. 2004. The UCSC Table Browser data retrieval tool. the benefit of being specific for AID targets. This model was used Nucleic Acids Res. 32: D493–D496. to predict AID targeting genome wide, and a set of 101 additional 19. Shapiro, G. S., K. Aviszus, J. Murphy, and L. J. Wysocki. 2002. Evolution of high-interest AID targets was identified for further experimental Ig DNA sequence to target specific base positions within codons for somatic hypermutation. J. Immunol. 168: 2302–2306. study. 20. Venables, W. N., and B. D. Ripley. 2002. 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Supplemental Figure 1. Mutation frequency at the individual gene level does not correlate with mRNA expression or hot / cold-spot frequency. A) The log2 of the average mRNA expression values across all germinal center B cell samples was obtained and compared to the mutation frequency. Genes are labeled according to the dKO group to which they belong. B) The frequency of the WRC SHM hotspot was calculated for each gene and normalized by the content of C/G in the sequence. Genes are labeled in the plot according to the dKO Group. C) The frequency of the SYC SHM coldspot was calculated for each gene and also normalized by the content of C/G in the sequence.

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Supplemental Figure 2. All Group A genes do not exhibit signs of clonal recruitment of AID. The fitted negative binomial distribution is shown fitted to each gene with open circles. A Chi-squared test was used to determine the goodness-of-fit for each model and Bonferroni-corrected cutoff for significance was p > 0.0033. A) Bcl6 (p = 0.777) B) Cd79a (p = 0.017) C) Cd79b (p = 0.845) D) Cd83 (p = 0.486) E) Ebf (p = 0.67) F) Eif4a2 (p = 0.71) G) Fas (p 0.996) H) H2afx (p = 0.835) I) Il21r (p = 0.819) J) Myc (p = 0.435) K) Ocab (p = 0.46) L) Pax5 (p = 0.823) M) Pim1 (p = 0.278) N) Rhoh (p = 0.492) O) Tde1 (p = 0.979).

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Supplemental Figure 3. Variable importance determines which variables are included for input into the classification tree model. All possible variables are shown and ordered from most to least important as determined through a random forest approach. Variables to the right of the red vertical dashed line improve the prediction accuracy significantly within the random forest and are thus important.

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Supplemental Table I. Prediction of genome-wide mutation frequency group from the classification tree model. Each gene is listed both by the RefSeq identifier and the associated gene symbol. Only genes predicted to be in groups A and B are listed. TC-Seq genes from Klein et al., 2011 predicted to be in groups A or B are also listed with their translocation partners from the study. TC-Seq genes were excluded from the analysis due to inclusion during model building (Bcl2l11, Ccnd2, Cd79b, Cd83, Ddx6, H2afx, Il21r, Myc, Pax5, Pim1), were not predicted by the model (Gas5, IgH, IgL-kappa, IgL- lambda, Irf2bp2, Mir142, Mir155, Nup62-il4i1, Phlpp1, Rnu12, Tmem49/Mir21), or were translocated in the AID-/- control (Pvt1). All other genes not listed were predicted to be in Group C and not listed.

Predicted Translocation NM_013852 Abcf3 A RefSeq Identifier Gene Symbol Group Partner NM_026185 Abhd15 A NM_001081365 0610010O12Rik A NM_022419 Abhd8 A NM_001159638 0610012H03Rik A NM_001077193 Abi1 A NM_029554 0610040J01Rik A NM_001103177 Ablim1 A NM_133697 1110003E01Rik A NM_133904 Acacb A NM_028637 1110034G24Rik A NM_025826 Acadsb A NM_025423 1110059E24Rik A NM_007424 Acan A NM_173758 1300010F03Rik A NM_001102437 Acbd5 A NM_001081005 1500012F01Rik A IgH NM_001034013 Accn1 A NM_029296 1700001C19Rik A NM_001085472 Acin1 A NM_029587 1700012A03Rik A NM_080633 Aco2 A NM_144953 1700019D03Rik A NM_012006 Acot1 A NM_027405 1700020O03Rik A NM_025590 Acot11 A NM_001162980 1700024P16Rik A NM_019800 Acp6 A NM_025969 1700034H14Rik A NM_007393 Actb A NM_183097 1700067K01Rik A NM_009608 Actc1 A NM_175148 2300002M23Rik A NM_009610 Actg2 A NM_026318 2310003F16Rik A NM_172126 Adam1a A NM_183281 2310005G13Rik A NM_172125 Adam1b A NM_027996 2310021P13Rik A NM_009620 Adam4 A NM_173735 2310044G17Rik A NM_007404 Adam9 A NM_027150 2310046A06Rik A NM_001081127 Adamts14 A NM_030208 2310079F23Rik A NM_175643 Adamts2 A NM_026629 2410066E13Rik A NM_001081401 Adamts3 A NM_028197 2510003E04Rik A NM_172723 Adap1 A NM_027420 2610034B18Rik A NM_023341 Adck3 A NM_026511 2810002N01Rik A NM_009624 Adcy9 A NM_028317 2810030E01Rik A NM_013758 Add3 A NM_026063 2900010M23Rik A NM_134079 Adk A NM_178399 3110035E14Rik A NM_182928 Adm2 A NM_133797 4833439L19Rik A NM_001008533 Adora1 A NM_029045 4930432K21Rik A NM_028121 Adpgk A NM_181815 4930534B04Rik A NM_009633 Adra2b A NM_001145537 4930544D05Rik A NM_007420 Adrb2 A NM_175228 4930578C19Rik A NM_178767 Agmo A NM_001077684 4930578N16Rik A NM_172715 Agpat9 A NM_172741 4931406P16Rik A NM_009642 Agtrap A NM_199019 4933407P14Rik A NM_172923 AI118078 A NM_028963 4933427D14Rik A NM_178906 AI593442 A NM_026362 5033414D02Rik A NM_145489 AI661453 A NM_029835 5730590G19Rik A NM_172393 Aim1 A NM_182995 6330503K22Rik A NM_001099299 Ajap1 A NM_145836 6430527G18Rik A NM_009647 Ak4 A NM_175398 6530418L21Rik A NM_198111 Akap6 A NM_145609 8430410K20Rik A NM_009656 Aldh2 A NM_172849 9430031J16Rik A NM_178713 Aldh8a1 A NM_172836 9930021J03Rik A NM_001142357 Alg12 A NM_001160360 A130010J15Rik A NM_001159948 Als2 A NM_001001982 A430105I19Rik A NM_009665 Amd1 A NM_173759 A730017C20Rik A NM_007444 Amd2 A NM_001160369 A830018L16Rik A NM_019496 Ammecr1 A NM_172399 A930038C07Rik A NM_153319 Amot A NM_177604 AA986860 A NM_028779 Ampd2 A NM_177762 Aak1 A NM_007447 Ang A NM_147219 Abca5 A NM_177544 Ang4 A NM_013850 Abca7 A NM_009640 Angpt1 A NM_170680 Abcc10 A NM_020332 Ank A NM_013853 Abcf2 A NM_178655 Ank2 A 4

NM_146033 Ankmy2 A NM_018745 Azin1 A NM_013468 Ankrd1 A NM_020283 B3galt1 A NM_133971 Ankrd10 A NM_145392 Bag2 A NM_001081379 Ankrd11 A NM_027404 Bag5 A NM_175455 Ankrd34b A NM_198423 Bahcc1 A NM_027799 Ankrd40 A NM_001037754 Baiap2 A NM_173779 Ankrd58 A NM_030060 Batf3 A NM_175207 Ankrd9 A NM_054078 Baz2a A NM_001128086 Anks1b A NM_133234 Bbc3 A NM_026187 Ankzf1 A NM_024473 BC005537 A NM_130889 Anp32b A NM_146222 BC024479 A NM_026887 Ap1s2 A NM_153584 BC031353 A NM_018829 Ap3m1 A NM_145943 BC031781 A NM_177034 Apba1 A NM_177673 BC046331 A NM_019456 Apbb1ip A NM_001001493 BC056474 A NM_011784 Aplnr A NM_001001334 BC061194 A NM_080434 Apoa5 A NM_029850 Bcl7a A NM_023114 Apoc3 A NM_029933 Bcl9 A NM_007472 Aqp1 A NM_030256 Bcl9l A NM_009700 Aqp4 A NM_175046 Bcor A NM_013476 Ar A NM_178782 Bcorl1 A NM_198096 Arap1 A NM_001048139 Bdnf A NM_009704 Areg A NM_026279 Bend5 A NM_007479 Arf4 A NM_178663 Bend7 A NM_176837 Arhgap18 A NM_001002896 Bfsp2 A NM_175164 Arhgap26 A NM_021560 Bhlhe22 A NM_183288 Arhgap27 A NM_024469 Bhlhe41 A NM_009706 Arhgap5 A NM_007557 Bmp7 A NM_178754 Arhgap6 A NM_172149 Bnip1 A NM_001081295 Arhgef26 A NM_134253 Bnipl A NM_177828 Arhgef37 A NM_177772 Bpifc A NM_029953 Arhgef38 A NM_020508 Brd4 A NM_152801 Arhgef6 A NM_144541 Bre A NM_017402 Arhgef7 A NM_027430 Brp44 A NM_001033329 Arhgef9 A NM_009766 Brs3 A NM_145996 Arid5a A IgH NM_145125 Brwd1 A NM_023598 Arid5b A NM_028709 Btbd11 A NM_019419 Arl6ip1 A NM_145534 Btbd3 A NM_026011 Arl8b A NM_027453 Btf3l4 A NM_001034858 Armc2 A NM_007569 Btg1 A NM_009709 Arnt A NM_007570 Btg2 A NM_033264 Arpp21 A NM_019493 Btg4 A NM_009713 Arsa A NM_177584 Btla A NM_009711 Artn A NM_079835 Btnl2 A NM_080847 Asb15 A NM_025840 Bzw2 A NM_007493 Asgr2 A NM_198417 C030039L03Rik A NM_019652 Asna1 A NM_007574 C1qc A NM_023113 Aspa A NM_145613 C1qtnf5 A NM_001029895 Ate1 A NM_023143 C1ra A NM_009715 Atf2 A NM_181344 C1rl A NM_009716 Atf4 A NM_029951 C330007P06Rik A NM_019426 Atf7ip A NM_194340 C330019G07Rik A NM_194348 Atg2a A NM_013485 C9 A NM_174875 Atg4a A NM_145851 Cables2 A NM_001003917 Atg9a A NM_001160252 Cabp2 A NM_001002897 Atg9b A NM_001159533 Cacna1c A NM_007500 Atoh1 A NM_001081023 Cacna1s A NM_153389 Atp10d A NM_146123 Cacnb4 A NM_172613 Atp13a4 A NM_007583 Cacng2 A NM_009721 Atp1b1 A NM_019430 Cacng3 A NM_133690 Atp1b4 A NM_207676 Cadm1 A NM_007504 Atp2a1 A NM_012061 Cadps A NM_016745 Atp2a3 A NM_001033954 Calca A NM_001036684 Atp2b2 A NM_009790 Calm1 A NM_177236 Atp2b3 A NM_007589 Calm2 A NM_016774 Atp5b A NM_007591 Calr A NM_009729 Atp6v0c A NM_177407 Camk2a A NM_013477 Atp6v0d1 A NM_001039138 Camk2g A NM_007509 Atp6v1b2 A NM_028420 Camk2n2 A NM_023721 Atp6v1d A NM_009793 Camk4 A NM_009124 Atxn1 A Myc NM_007603 Capn6 A NM_001098836 Atxn7l3 A NM_001037747 Card9 A NM_001033221 AU023871 A NM_026995 Carkd A NM_177746 Awat2 A NM_029617 Casc5 A

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NM_009806 Cask A NM_009601 Chrnb1 A NM_027195 Casz1 A NM_021439 Chst11 A NM_028763 Cbx6 A NM_016803 Chst3 A IgH and Myc NM_013926 Cbx8 A NM_011998 Chst4 A NM_145970 Cc2d1a A NM_001081163 Chsy1 A NM_178793 Ccbe1 A NM_007705 Cirbp A NM_146178 Ccdc106 A NM_009897 Ckmt1 A NM_001037913 Ccdc107 A NM_001081960 Clasp2 A NM_001039495 Ccdc108 A NM_019952 Clcf1 A NM_029779 Ccdc116 A NM_016674 Cldn1 A NM_207202 Ccdc120 A NM_001160099 Cldn10 A NM_001025576 Ccdc141 A NM_029383 Cldn22 A NM_001081266 Ccdc142 A NM_018778 Cldn8 A NM_030025 Ccdc150 A NM_013885 Clic4 A NM_026222 Ccdc39 A NM_001045520 Clint1 A NM_001101535 Ccdc8 A NM_001081114 Clip3 A NM_001159910 Ccdc85c A NM_030179 Clip4 A NM_176841 Ccdc88a A NM_001040682 Clmn A NM_026681 Ccdc88c A NM_153384 Clrn1 A NM_001159738 Ccl20 A NM_028940 Clvs1 A NM_009828 Ccna2 A NM_001033317 Cnga4 A NM_007632 Ccnd3 A NM_177129 Cntn2 A NM_007635 Ccng2 A NM_001109751 Cntn4 A NM_001045530 Ccnjl A NM_017383 Cntn6 A NM_009832 Ccnk A NM_009926 Col11a2 A NM_019937 Ccnl1 A NM_001109991 Col18a1 A NM_028181 Ccpg1 A NM_130449 Colec12 A NM_009915 Ccr2 A NM_147778 Commd3 A NM_009839 Cct6b A NM_030205 Coro7 A NM_016898 Cd164 A NM_009943 Cox6a2 A NM_001159558 Cd36 A NM_025350 Cpa1 A NM_011616 Cd40lg A NM_026252 Cpeb4 A NM_007653 Cd63 A NM_027904 Cpn2 A NM_007656 Cd82 A NM_153507 Cpne2 A NM_010740 Cd93 A NM_009947 Cpne6 A NM_009861 Cdc42 A NM_001080809 Cps1 A NM_183016 Cdc42bpb A NM_026682 Cpsf4l A NM_001038708 Cdc42se1 A NM_013495 Cpt1a A NM_009862 Cdc45 A NM_013496 Crabp1 A NM_009866 Cdh11 A NM_133239 Crb1 A NM_001081299 Cdh18 A NM_172728 Creb5 A NM_001039154 Cdh8 A NM_011804 Creg1 A NM_001114322 Cdhr5 A NM_029720 Creld2 A NM_007661 Cdk11b A NM_001110853 Crem A NM_001109628 Cdk12 A NM_205769 Crh A NM_011049 Cdk16 A NM_025646 Crls1 A NM_026373 Cdk2ap2 A NM_001136058 Crmp1 A NM_007671 Cdkn2c A NM_133679 Cryzl1 A NM_009878 Cdkn2d A NM_001037859 Csf1r A NM_177647 Cdnf A NM_009971 Csf3 A NM_029441 Cdyl2 A NM_173185 Csnk1g1 A NM_001146293 Celf4 A NM_030137 Cstad A NM_009886 Celsr1 A NM_013502 Ctbp1 A NM_001004177 Celsr2 A NM_026017 Ctdnep1 A NM_007682 Cenpb A NM_201354 Ctif A NM_026643 Cep57l1 A NM_007614 Ctnnb1 A NM_009887 Cer1 A NM_022325 Ctsz A NM_053200 Ces1d A NM_018866 Cxcl13 A NM_008198 Cfb A NM_019568 Cxcl14 A NM_007687 Cfl1 A NM_203320 Cxcl3 A NM_026929 Chac1 A NM_009911 Cxcr4 A NM_001081345 Chd2 A NM_001004367 Cxxc4 A NM_145979 Chd4 A NM_007810 Cyp19a1 A NM_001081376 Chd5 A NM_010009 Cyp27b1 A NM_201637 Chd8 A NM_020010 Cyp51 A NM_145126 Chi3l4 A NM_021476 Cysltr1 A NM_013490 Chka A NM_139200 Cytip A NM_021350 Chml A NM_028043 D1Bwg0212e A NM_025519 Chmp4c A NM_023665 D4Wsu53e A IgH NM_139134 Chodl A NM_172681 D930015E06Rik A NM_001001566 Chpf A NM_033605 Dach2 A NM_001146690 Chpt1 A NM_001081655 Dact3 A NM_001112697 Chrm1 A NM_198114 Dagla A NM_033269 Chrm3 A NM_031403 Dbr1 A

3

NM_173408 Dcun1d3 A NM_145941 Eif4g1 A NM_001110222 Dcx A NM_001040131 Eif4g2 A NM_016765 Ddah2 A NM_178041 Eif5 A NM_030143 Ddit4l A NM_010488 Elavl4 A NM_001013741 Ddn A NM_001163131 Elf3 A NM_172779 Ddx26b A NM_170777 Elof1 A NM_010028 Ddx3x A NM_001039176 Elovl1 A NM_007840 Ddx5 A NM_029001 Elovl7 A NM_001037247 Defb36 A NM_023876 Elp4 A NM_033562 Derl2 A NM_001081191 Eml5 A NM_001080711 Dfnb59 A NM_010133 En1 A NM_001109750 Dgcr2 A NM_001136062 Eno3 A NM_178681 Dgkb A NM_177304 Enpp6 A NM_019505 Dgke A NM_177821 Ep300 A NM_138650 Dgkg A NM_001128607 Epb4.1 A NM_011303 Dhrs3 A NM_007938 Epha6 A NM_007842 Dhx9 A NM_010142 Ephb2 A NM_172493 Diap2 A NM_001159964 Eps15 A NM_010050 Dio2 A NM_022313 Eral1 A NM_001159361 Dip2b A NM_029972 Ermn A NM_007862 Dlg1 A NM_026184 Ero1lb A NM_011807 Dlg2 A NM_026129 Erp29 A NM_010053 Dlx1 A NM_027102 Esam A NM_010054 Dlx2 A NM_023612 Esm1 A NM_130865 Dmbx1 A NM_019585 Espn A NM_007868 Dmd A NM_176838 Esrp2 A NM_016779 Dmp1 A NM_144866 Etf1 A NM_015826 Dmrt1 A NM_025794 Etfdh A NM_001081330 Dnahc2 A NM_007960 Etv1 A NM_008298 Dnaja1 A NM_008815 Etv4 A NM_013760 Dnajb9 A NM_007966 A NM_198412 Dnajc6 A NM_021388 Extl2 A NM_007870 Dnase1l3 A NM_010164 Eya1 A NM_152915 Dner A NM_211357 Eya3 A NM_033374 Dock2 A NM_007972 F10 A NM_177780 Dock5 A NM_010171 F3 A NM_013739 Dok3 A NM_017399 Fabp1 A NM_058212 Dpf3 A NM_024406 Fabp4 A NM_010072 Dpm1 A NM_011598 Fabp9 A NM_010075 Dpp6 A NM_001122851 Faim A NM_172920 Dpy19l1 A NM_001013792 Fam105b A NM_027878 Dram1 A NM_146096 Fam108b A NM_007877 Drd3 A NM_001114541 Fam113a A NM_013505 Dsc2 A NM_146119 Fam129b A NM_001081270 Dscaml1 A NM_170755 Fam134a A NM_019771 Dstn A NM_028933 Fam134c A NM_001162465 Dtnb A NM_177819 Fam135b A NM_030714 Dtx3 A NM_153574 Fam13a A NM_001099297 Duox1 A NM_001081096 Fam154a A NM_177610 Duox2 A NM_177838 Fam163a A NM_013642 Dusp1 A NM_001081225 Fam178a A NM_001048054 Dusp16 A NM_177869 Fam185a A NM_010090 Dusp2 A NM_001114174 Fam189a2 A NM_001159646 Dut A NM_182807 Fam19a2 A NM_007888 Dvl2 A NM_134096 Fam19a5 A NM_001037957 Dyrk1b A NM_145413 Fam20b A NM_025943 Dzip1 A NM_001081165 Fam26d A NM_183160 E030010A14Rik A NM_001160379 Fam46a A NM_010093 A NM_138746 Fam50b A NM_001013368 E2f8 A NM_207583 Fam5b A NM_153548 E430025E21Rik A NM_178658 Fam65b A NM_177942 Ece2 A NM_145553 Fam76a A NM_001039644 Edem3 A NM_173862 Fam83a A NM_018796 Eef1b2 A NM_001033170 Fam83e A NM_007907 Eef2 A NM_026753 Fam96b A NM_007908 Eef2k A NM_133747 Fam98a A NM_001082483 Efr3b A NM_178912 Fancm A NM_010113 Egf A NM_001029988 Fat2 A NM_019397 Egfl6 A NM_001080814 Fat3 A NM_053207 Egln1 A NM_011812 Fbln5 A NM_010119 Ehd1 A NM_007994 Fbp2 A NM_007914 Ehf A NM_010183 Fbrs A NM_010709 Eif2d A NM_133940 Fbxl14 A NM_026114 Eif2s1 A NM_015795 Fbxo16 A

4

NM_028049 Fbxo22 A NM_008110 Gdf9 A NM_175127 Fbxo28 A NM_010279 Gfra1 A NM_177598 Fbxw13 A NM_008128 Gjb6 A NM_015793 Fbxw14 A NM_138595 Gldc A NM_199036 Fbxw15 A NM_010296 Gli1 A NM_177070 Fbxw16 A NM_001081125 Gli2 A NM_001033794 Fbxw18 A NM_021332 Glp1r A NM_177703 Fbxw19 A NM_175681 Glp2r A NM_001008428 Fbxw20 A NM_010298 Glrb A NM_177069 Fbxw21 A NM_008131 Glul A NM_001014395 Fbxw22 A NM_174846 Glyctk A NM_001013776 Fbxw24 A NM_001126320 Gm11563 A NM_198674 Fbxw26 A NM_001037929 Gm14092 A NM_001136556 Fer1l4 A NM_001039223 Gm14137 A NM_033522 Ferd3l A NM_001033459 Gm1679 A NM_080433 Fezf2 A NM_001101630 Gm3238 A NM_139234 Fgd4 A NM_001101631 Gm3285 A NM_010199 Fgf12 A NM_173864 Gm5077 A NM_010200 Fgf13 A NM_001080940 Gm6484 A NM_020013 Fgf21 A NM_001037931 Gm6878 A NM_022657 Fgf23 A NM_001033448 Gm962 A NM_010203 Fgf5 A NM_010301 Gna11 A NM_008008 Fgf7 A NM_001113384 Gnao1 A NM_021716 Fign A NM_201618 Gnas A NM_001159573 Fip1l1 A NM_001081143 Gnat3 A NM_011813 Fiz1 A NM_010312 Gnb2 A NM_001013804 Flg2 A NM_013747 Golga5 A NM_010227 Flna A NM_010324 Got1 A NM_001081185 Flnc A NM_010274 Gpd2 A NM_001040403 Flot2 A NM_181751 Gpr119 A NM_201411 Flrt1 A NM_008151 Gpr12 A NM_019445 Fmn2 A NM_001081220 Gpr179 A NM_010233 Fn1 A NM_008157 Gpr19 A NM_001114665 Fnbp1l A NM_027677 Gpr39 A NM_027402 Fndc5 A NM_001146330 Gpr52 A NM_008036 Fosb A NM_175520 Gpr81 A NM_010446 Foxa2 A NM_032399 Gpr87 A NM_008023 Foxb2 A NM_173036 Gpr97 A NM_013519 Foxc2 A NM_008160 Gpx1 A NM_021899 Foxj2 A NM_001037741 Gpx4 A NM_008024 Foxl1 A NM_153528 Gramd1c A NM_018789 Foxo4 A NM_013535 Grcc10 A NM_194060 Foxo6 A NM_001161406 Grhl1 A NM_053202 Foxp1 A NM_001013756 Grhl3 A NM_175473 Fras1 A NM_013540 Gria2 A NM_177863 Frem1 A NM_016886 Gria3 A NM_028194 Fryl A NM_130891 Grip1 A NM_007984 Fscn1 A NM_207670 Gripap1 A NM_008046 Fst A NM_011153 Gsbs A NM_010239 Fth1 A NM_010362 Gsto1 A NM_011046 Furin A NM_031391 Gtf2a1 A IgH NM_139149 Fus A NM_145546 Gtf2b A NM_016893 Fut8 A NM_028812 Gtf2e1 A NM_019503 Fxyd1 A NM_133801 Gtf2f1 A NM_052823 Fxyd2 A NM_013755 Gyg A NM_013716 G3bp1 A NM_207105 H2-Ab1 A NM_001080797 G3bp2 A NM_010380 H2-D1 A NM_001033805 G630016D24Rik A NM_010386 H2-DMa A NM_181584 Gab3 A NM_001001892 H2-K1 A NM_019749 Gabarap A NM_001143689 H2-Q4 A NM_008067 Gabra3 A NM_008211 H3f3b A NM_177408 Gabrg2 A NM_008217 Has3 A NM_008074 Gabrg3 A NM_011826 Hax1 A NM_008655 Gadd45b A NM_175000 Hbq1a A NM_134189 Galnt10 A NM_001033981 Hbq1b A NM_001161767 Galnt6 A NM_198962 Hcrtr2 A NM_173739 Galntl4 A NM_144919 Hdac11 A NM_008084 Gapdh A NM_008232 Hdgfl1 A NM_008088 Gas7 A NM_172637 Hectd2 A NM_010292 Gck A NM_001001883 Hecw2 A NM_144909 Gckr A NM_173789 Helt A NM_173442 Gcnt1 A NM_053149 Hemgn A NM_008105 Gcnt2 A NM_022331 Herpud1 A NM_010266 Gda A NM_019479 Hes6 A

5

NM_010420 Hesx1 A NM_001160403 Il1rapl1 A NM_027658 Hexim2 A NM_080729 Il25 A NM_001098203 Hic1 A NM_016671 Il27ra A NM_010431 Hif1a A NM_021283 Il4 A NM_015786 Hist1h1c A NM_010559 Il6ra A NM_015787 Hist1h1e A IgH NM_008373 Il9 A NM_178182 Hist1h2ai A NM_028260 Immp1l A NM_178184 Hist1h2an A NM_016692 Incenp A NM_178199 Hist1h2bl A NM_023626 Ing3 A NM_178202 Hist1h2bp A NM_008382 Inhbe A NM_178205 Hist1h3e A NM_026574 Ino80 A NM_013548 Hist1h3f A NM_008385 Inpp5b A NM_178208 Hist1h4c A NM_172439 Inpp5j A NM_175657 Hist1h4n A NM_153526 Insig1 A NM_175662 Hist2h2ac A IgH NM_016889 Insm1 A NM_175666 Hist2h2bb A IgH NM_008715 Ints6 A NM_178214 Hist2h2be A NM_029634 Ip6k2 A NM_010437 Hivep2 A NM_177585 Iqcj A NM_010657 Hivep3 A NM_001134384 Iqsec1 A NM_008253 Hmgb3 A NM_001159396 Irf1 A NM_016957 Hmgn2 A NM_008391 Irf2 A NM_016710 Hmgn5 A NM_178757 Irf2bp1 A NM_013552 Hmmr A NM_008320 Irf8 A NM_010442 Hmox1 A NM_001081212 Irs2 A NM_008258 Hn1 A NM_018885 Irx4 A NM_001039129 Hnrnpa1 A NM_026921 Isca1 A NM_001081196 Hnrnpul2 A NM_001113527 Isg20 A NM_030014 Hook1 A NM_021459 Isl1 A NM_010453 Hoxa5 A NM_027397 Isl2 A NM_008266 Hoxb1 A NM_025478 Isoc1 A NM_008267 Hoxb13 A NM_001101598 Isoc2a A NM_008270 Hoxb9 A NM_010577 Itga5 A NM_175730 Hoxc5 A NM_027120 Itgb1bp3 A NM_010466 Hoxc8 A NM_010586 Itpr2 A NM_013554 Hoxd10 A NM_080553 Itpr3 A NM_008273 Hoxd11 A NM_001033380 Itpripl2 A NM_008275 Hoxd13 A NM_010587 Itsn1 A NM_174998 Hpcal4 A NM_008412 Ivl A NM_001081257 Hpse2 A NM_030887 Jdp2 A NM_021877 Hr A NM_020605 Jph3 A NM_053176 Hrg A NM_010590 Jub A NM_133698 Hrnr A NM_008416 Junb A IgH and Myc NM_011828 Hs2st1 A NM_010593 Jup A NM_010474 Hs3st1 A NM_172872 Kank4 A NM_019657 Hsd17b12 A NM_178929 Kazald1 A NM_008297 Hsf2 A NM_001081087 Kbtbd10 A NM_001045527 Hsf5 A NM_001102670 Kbtbd8 A NM_008302 Hsp90ab1 A NM_001025581 Kcnc2 A NM_011631 Hsp90b1 A NM_019697 Kcnd2 A NM_015765 Hspa14 A NM_001081134 Kcng1 A NM_011020 Hspa4l A NM_001110227 Kcnj13 A NM_022310 Hspa5 A NM_008425 Kcnj2 A NM_031165 Hspa8 A NM_008431 Kcnk4 A NM_010481 Hspa9 A NM_080465 Kcnn2 A NM_024172 Hspbp1 A NM_001081027 Kcnt2 A NM_008309 Htr1d A NM_177715 Kctd12 A NM_008313 Htr4 A NM_026135 Kctd16 A NM_001081187 Htra4 A NM_177791 Kctd19 A NM_015755 Hunk A NM_001111028 Kctd9 A NM_008316 Hus1 A NM_001003953 Kdm2b A NM_021395 Hyou1 A NM_001017426 Kdm6b A NM_010493 Icam1 A NM_010616 Kif12 A NM_010500 Ier5 A NM_010617 Kif13a A NM_008337 Ifng A NM_001081133 Kif16b A NM_001111274 Igf1 A NM_001109040 Kif21a A NM_001122737 Igf2 A NM_024245 Kif23 A NM_010518 Igfbp5 A NM_013692 Klf10 A NM_183336 Igsf1 A NM_008452 Klf2 A NM_010544 Ihh A NM_011803 Klf6 A NM_001025597 Ikzf1 A NM_033563 Klf7 A NM_011770 Ikzf2 A NM_173780 Klf8 A NM_175115 Ikzf5 A NM_010638 Klf9 A NM_010548 Il10 A NM_029742 Klhdc10 A NM_008361 Il1b A NM_173427 Klhdc7a A

6

NM_053105 Klhl1 A NM_178678 Lrrtm3 A NM_145479 Klhl22 A NM_175548 Lsamp A NM_029436 Klhl24 A NM_001136071 Lsp1 A NM_001081667 Klhl34 A NM_020490 Ltb4r2 A NM_183390 Klhl6 A NM_010736 Ltbr A NM_133712 Klk10 A NM_008521 Ltc4s A NM_028660 Klk9 A NM_008522 Ltf A NM_145416 Kri1 A NM_008524 Lum A NM_008473 Krt1 A NM_178705 Luzp2 A NM_010660 Krt10 A NM_001111096 Lyn A NM_008469 Krt15 A NM_133743 Lypd3 A NM_010668 Krt2 A NM_029610 Lyrm1 A NM_008476 Krt6a A NM_027309 Lysmd2 A NM_019956 Krt71 A NM_011839 Mab21l2 A NM_001003667 Krt77 A NM_175296 Mael A NM_146063 Krt79 A NM_194350 Mafa A NM_001024709 Krtap10-10 A NM_023788 Mageh1 A NM_001135991 Krtap10-4 A NM_001083320 Magi1 A NM_001113406 Krtap11-1 A NM_015823 Magi2 A NM_183189 Krtap13-1 A NM_178920 Mal2 A NM_013707 Krtap14 A NM_001004176 Maml3 A NM_025720 Krtap3-2 A NM_009157 Map2k4 A NM_025524 Krtap3-3 A NM_011840 Map2k5 A NM_008477 Ktn1 A NM_001081292 Map3k10 A NM_010681 Lama4 A NM_022012 Map3k11 A NM_008483 Lamb2 A NM_008580 Map3k5 A NM_028451 Larp1 A NM_007746 Map3k8 A NM_153168 Lars2 A NM_009158 Mapk10 A NM_010688 Lasp1 A NM_011951 Mapk14 A NM_172856 Lass6 A NM_015806 Mapk6 A NM_029999 Lbh A NM_016700 Mapk8 A NM_001081071 Lclat1 A NM_178907 Mapkapk3 A NM_025304 Lcmt1 A NM_153058 Mapre2 A NM_001018087 Ldoc1 A NM_008538 Marcks A NM_001033250 Lemd1 A NM_010807 Marcksl1 A NM_020517 Lenep A NM_145515 Mark1 A NM_013534 Leprel2 A NM_001080390 Mark2 A NM_008496 Lgals7 A NM_001038602 Marveld2 A NM_020278 Lgi1 A NM_008555 Masp1 A NM_145219 Lgi3 A NM_019945 Mast1 A NM_172671 Lgr4 A NM_133653 Mat1a A NM_178358 Lhfpl1 A NM_013593 Mb A NM_001081231 Lhfpl3 A NM_033072 Mbd6 A NM_010712 Lhx4 A NM_008562 Mcl1 A IgH and Myc NM_001083125 Lhx6 A NM_021442 Mecom A NM_001039537 Lif A NM_025885 Med19 A NM_023063 Lima1 A NM_011869 Med24 A NM_175186 Lin9 A NM_026896 Med27 A NM_177250 Lingo4 A NM_173719 Med8 A NM_027340 Lipn A NM_025282 Mef2c A NM_145438 Llgl2 A NM_001001979 Megf10 A NM_025828 Lman2 A NM_010789 Meis1 A NM_001161770 Lmo4 A NM_010825 Meis2 A NM_001081157 Lmod3 A NM_008584 Meox2 A NM_001081109 Lmtk2 A NM_030705 Mesdc1 A NM_010725 Lmx1b A NM_008591 Met A NM_010727 Lnx1 A NM_175224 Metap1 A NM_028782 Lonp1 A NM_001143956 Mettl11b A NM_028894 Lonrf3 A NM_029568 Mfap4 A NM_010729 Loxl1 A NM_147126 Mfrp A NM_008509 Lpl A NM_133829 Mfsd6 A NM_027452 Lrfn2 A NM_028140 Mfsd8 A NM_008512 Lrp1 A NM_013720 Mga A NM_053011 Lrp1b A NM_001110150 Mgat1 A NM_198119 Lrrc24 A NM_146035 Mgat2 A NM_001033371 Lrrc36 A NM_001162369 Mgat4c A NM_138682 Lrrc4 A NM_145128 Mgat5 A NM_001162974 Lrrc51 A NM_011844 Mgll A NM_001013382 Lrrc52 A NM_183151 Mid1 A NM_001033346 Lrrc55 A NM_026524 Mid1ip1 A NM_001081358 Lrrc7 A NM_011845 Mid2 A NM_178701 Lrrc8d A NM_001039081 Mier1 A NM_028880 Lrrtm1 A NM_001113198 Mitf A NM_178005 Lrrtm2 A NM_001039684 Mks1 A

7

NM_010804 Mllt10 A NM_010901 Nfatc3 A NM_019914 Mllt11 A NM_001130453 Nfe2l1 A NM_133917 Mlxip A NM_001122952 Nfia A NM_019724 Mmp16 A NM_017373 Nfil3 A IgH NM_021412 Mmp19 A NM_001081981 Nfix A NM_008611 Mmp8 A NM_010907 Nfkbia A IgH NM_013599 Mmp9 A NM_001159395 Nfkbiz A NM_001113374 Mocs2 A NM_133921 Nfxl1 A NM_028369 Mon1a A NM_001081052 Nhs A NM_029413 Morc4 A NM_001081453 Nin A NM_001143683 Mpped2 A NM_145469 Nipal2 A NM_025553 Mrpl11 A NM_172524 Nipal4 A NM_175001 Mrpl22 A NM_009385 Nkx2-1 A NM_001031808 Mrpl41 A NM_008699 Nkx2-3 A NM_023331 Mrpl46 A NM_029002 Nkx6-3 A NM_026498 Mrps11 A NM_008708 Nmt2 A NM_028722 Msl1 A NM_199024 Nol4 A NM_172308 Mthfd1l A NM_001159599 Nol9 A NM_016985 Mtmr1 A NM_024193 Nop56 A NM_029920 Mtus2 A NM_001109985 Nos1ap A NM_001161824 Mtx1 A NM_008713 Nos3 A NM_172979 Muc15 A NM_175263 Notum A NM_026751 Myadml2 A NM_198958 Nox3 A NM_019660 Mycbp A NM_013780 Npas3 A NM_008657 Myf6 A NM_001081152 Npat A NM_175260 Myh10 A NM_001013360 Npcd A NM_028021 Myh14 A NM_008730 Nptx1 A NM_010855 Myh4 A NM_011850 Nr0b2 A NM_177369 Myh8 A NM_145434 Nr1d1 A NM_022410 Myh9 A NM_013839 Nr1h3 A NM_181043 Mylip A NM_152229 Nr2e1 A NM_001081219 Myo1a A NM_010151 Nr2f1 A NM_177390 Myo1d A NM_010150 Nr2f6 A NM_001033621 Myot A NM_008733 Nrap A NM_182992 Mypn A NM_025980 Nrarp A NM_144557 Myrip A NM_176930 Nrcam A NM_177619 Myst2 A NM_178591 Nrg1 A NM_017479 Myst4 A NM_172544 Nrxn3 A NM_008665 Myt1 A NM_008739 Nsd1 A NM_001093776 Myt1l A NM_010942 Nsg1 A NM_133898 N4bp2l1 A NM_008741 Nsg2 A NM_019870 Naa10 A NM_026746 Nsmce2 A NM_008667 Nab1 A NM_028950 Nsun6 A NM_001037098 Nacc2 A NM_027588 Nt5c1b A NM_194064 Nanos2 A NM_182809 Ntrk3 A NM_194059 Nanos3 A NM_018766 Ntsr1 A NM_021432 Nap1l5 A NM_026023 Nudcd2 A NM_025898 Napa A NM_173748 Nudcd3 A NM_019632 Napb A NM_026623 Nudt21 A NM_178728 Napepld A NM_001024205 Nufip2 A NM_172607 Naprt1 A NM_019738 Nupr1 A NM_008673 Nat1 A NM_008752 Nxph2 A NM_173437 Nav1 A NM_181748 O3far1 A NM_001081035 Nav3 A NM_028696 Obfc2a A NM_173444 Nbeal1 A NM_172907 Olfml1 A NM_008676 Nbr1 A NM_146571 Olfr1015 A NM_001113208 Ncam2 A NM_146586 Olfr1018 A NM_010878 Nck1 A NM_146587 Olfr1023 A NM_016965 Nckap1 A NM_207142 Olfr1036 A NM_010880 Ncl A NM_147019 Olfr1054 A NM_010881 Ncoa1 A NM_146769 Olfr1110 A NM_172495 Ncoa7 A NM_001011734 Olfr1116-ps A NM_029561 Ndfip2 A NM_207632 Olfr1118 A NM_023239 Ndnl2 A NM_146348 Olfr1121 A NM_010883 Ndp A NM_146350 Olfr1123 A NM_008681 Ndrg1 A NM_146531 Olfr1168 A NM_022565 Ndst4 A NM_207566 Olfr1173 A NM_010886 Ndufa4 A NM_146893 Olfr1216 A NM_026614 Ndufa5 A NM_146818 Olfr1218 A NM_023247 Ndufaf3 A NM_146341 Olfr1259 A NM_001160039 Ndufs1 A NM_146474 Olfr1261 A NM_010887 Ndufs4 A NM_146343 Olfr1265 A NM_001039094 Negr1 A NM_146342 Olfr1269 A NM_198429 Nfatc1 A NM_146263 Olfr1274-ps A

8

NM_146541 Olfr1361 A NM_001011785 Olfr987 A NM_146744 Olfr1362 A NM_011010 Omp A NM_146685 Olfr1433 A NM_133752 Opa1 A NM_207626 Olfr1434 A NM_052976 Ophn1 A NM_001011839 Olfr1437 A NM_007538 Opn1sw A NM_146313 Olfr145 A NM_144854 ORF63 A NM_146505 Olfr148 A NM_177614 Os9 A NM_207138 Olfr149 A NM_001134791 Osbpl9 A NM_146265 Olfr1506 A NM_175632 Oscar A NM_146431 Olfr1510 A NM_019935 Ovol1 A NM_207572 Olfr1535 A NM_026924 Ovol2 A NM_207665 Olfr1537-ps1 A NM_153400 P2rx2 A NM_019476 Olfr159 A NM_145526 P2rx3 A NM_020598 Olfr17 A NM_011027 P2rx7 A NM_146484 Olfr197 A NM_011030 P4ha1 A NM_001011808 Olfr198 A NM_019402 Pabpn1 A NM_010983 Olfr2 A NM_153129 Pacs1 A NM_146759 Olfr214 A NM_001081170 Pacs2 A NM_001001809 Olfr218 A NM_177326 Pak2 A NM_001001808 Olfr221 A NM_172868 Palm2 A NM_146613 Olfr229 A NM_001085376 Pappa2 A NM_146686 Olfr235 A NM_019574 Patz1 A NM_010974 Olfr242 A NM_011039 Pax7 A NM_146770 Olfr259 A NM_001103165 Pcbp2 A NM_001011733 Olfr288 A NM_001098171 Pcdh10 A NM_146710 Olfr398 A NM_017378 Pcdh12 A NM_207622 Olfr403 A NM_023115 Pcdh15 A NM_146707 Olfr410 A NM_130448 Pcdh18 A NM_207137 Olfr417 A NM_001105245 Pcdh19 A NM_146711 Olfr43 A NM_001042726 Pcdh8 A NM_146716 Olfr432 A NM_009959 Pcdha5 A NM_001011799 Olfr453 A NM_007767 Pcdha6 A NM_146444 Olfr458 A NM_053126 Pcdhb1 A NM_146576 Olfr459 A NM_053143 Pcdhb18 A NM_146383 Olfr460 A NM_053127 Pcdhb2 A NM_146925 Olfr481 A NM_053146 Pcdhb21 A NM_146497 Olfr492 A NM_033584 Pcdhga1 A NM_146364 Olfr495 A NM_033591 Pcdhga8 A NM_146723 Olfr513 A NM_033582 Pcdhgc4 A NM_146356 Olfr521 A NM_029078 Pcf11 A NM_146755 Olfr551 A NM_011044 Pck1 A NM_146757 Olfr583 A NM_028994 Pck2 A NM_001011847 Olfr591 A NM_144868 Pcnxl3 A NM_146380 Olfr593 A NM_008788 Pcolce A NM_146822 Olfr640 A NM_025557 Pcp4l1 A NM_146379 Olfr654 A NM_211138 Pcyt1b A NM_147096 Olfr666 A NM_001159953 Pde1c A NM_147060 Olfr667 A NM_018779 Pde3a A NM_001011857 Olfr685 A NM_011055 Pde3b A NM_147069 Olfr686 A NM_019840 Pde4b A NM_146598 Olfr695 A NM_008801 Pde6d A NM_146602 Olfr698 A NM_011057 Pdgfb A NM_001011862 Olfr699 A NM_172665 Pdk1 A NM_146600 Olfr700 A NM_133667 Pdk2 A NM_146596 Olfr703 A NM_019808 Pdlim5 A NM_001011749 Olfr704 A NM_001098231 Pdp1 A NM_146353 Olfr706 A NM_001024606 Pdp2 A NM_147033 Olfr714 A NM_019501 Pdss1 A NM_146493 Olfr730 A NM_033602 Peli2 A NM_001011821 Olfr804 A NM_001002927 Penk A NM_146324 Olfr809 A NM_011065 Per1 A NM_207147 Olfr813 A NM_011067 Per3 A NM_001011523 Olfr913 A NM_008827 Pgf A NM_146442 Olfr934 A NM_007905 Phc1 A NM_146439 Olfr937 A NM_174852 Phf12 A NM_146506 Olfr945 A NM_172303 Phf17 A NM_001011756 Olfr948 A NM_138755 Phf21a A NM_146331 Olfr954 A NM_026737 Phf5a A NM_146330 Olfr958 A NM_016966 Phgdh A NM_146508 Olfr959 A NM_001081216 Phip A NM_146514 Olfr96 A NM_153537 Phldb1 A NM_146614 Olfr971 A NM_001122594 Phlpp2 A NM_147105 Olfr978 A NM_153104 Phospho1 A NM_146608 Olfr984 A NM_175356 Pi4kb A

9

NM_001045558 Pick1 A NM_026988 Ptms A NM_031376 Pik3ap1 A NM_011201 Ptpn1 A NM_029094 Pik3cb A NM_001077705 Ptpn6 A NM_008840 Pik3cd A NM_029928 Ptprb A NM_178149 Pik3ip1 A NM_001014288 Ptprd A NM_008846 Pip5k1b A NM_008984 Ptprm A NM_177298 Pisd A NM_008989 Pura A NM_029686 Pkd1l2 A NM_021424 Pvrl1 A NM_145378 Pla2g4b A NM_001159516 Qk A NM_016915 Pla2g6 A NM_029128 Qtrtd1 A NM_019538 Plac1 A NM_181070 Rab18 A NM_019677 Plcb1 A NM_011226 Rab19 A NM_021280 Plcg1 A NM_029494 Rab30 A NM_183191 Plch1 A NM_175122 Rab39b A NM_001134480 Plcxd2 A NM_031874 Rab3d A NM_001159942 Plekhg1 A NM_001003950 Rab3ip A NM_177606 Plekhh2 A NM_001039394 Rab43 A NM_146030 Plekhh3 A NM_024456 Rab5c A NM_153119 Plekho2 A NM_144875 Rab7l1 A NM_013807 Plk3 A NM_176971 Rab9b A NM_172775 Plxnb1 A NM_001042499 Rabl3 A NM_018797 Plxnc1 A NM_009008 Rac2 A NM_021451 Pmaip1 A NM_009011 Rad23b A NM_173180 Pmpca A NM_018740 Rai12 A NM_012040 Pnck A NM_001103367 Rai2 A NM_175498 Pnma2 A NM_177658 Ralgapb A NM_001034885 Pnpla1 A NM_023130 Raly A NM_172874 Podn A NM_178631 Ralyl A NM_181579 Pof1b A NM_011240 Ranbp2 A NM_178627 Poldip3 A NM_198024 Ranbp3l A NM_015810 Polg2 A NM_001081155 Rap1gap A NM_198933 Pou2f1 A NM_144850 Rapgef3 A NM_011139 Pou2f3 A NM_019688 Rapgef4 A NM_008899 Pou3f2 A NM_009027 Rasgrf2 A NM_008901 Pou3f4 A NM_001013386 Rasl10b A NM_138945 Pou4f3 A NM_175279 Rassf10 A NM_010127 Pou6f1 A NM_183024 Raver2 A NM_008904 Ppargc1a A NM_009029 Rb1 A NM_133249 Ppargc1b A NM_172517 Rbbp5 A NM_001033319 Ppfia1 A NM_183188 Rbfox1 A NM_008905 Ppfibp2 A NM_001081425 Rbm24 A NM_008889 Ppp1r14b A NM_133925 Rbm28 A NM_133485 Ppp1r14c A NM_009032 Rbm4 A NM_153089 Ppp1r16b A IgH NM_011255 Rbp4 A NM_172994 Ppp2r2c A NM_001100591 Rc3h2 A NM_008914 Ppp3cb A NM_207649 Rcan2 A NM_019441 Ppt2 A NM_026557 Rchy1 A NM_001080771 Prdm13 A NM_021525 Rcl1 A NM_029947 Prdm8 A NM_178606 Reep3 A NM_133364 Prima1 A NM_009045 Rela A NM_145401 Prkag2 A NM_011263 Rest A NM_008860 Prkcz A NM_016846 Rgl1 A NM_178891 Prmt6 A NM_023622 Rgl3 A NM_008937 Prox1 A NM_021340 Rgr A NM_029294 Prps1l1 A NM_009061 Rgs2 A NM_030024 Prr15 A NM_015812 Rgs6 A NM_001030296 Prr7 A NM_145383 Rho A NM_172661 Prrc2b A NM_016802 Rhoa A NM_001025570 Prrx1 A NM_145491 Rhoq A NM_173347 Prune A NM_145495 Rin1 A NM_175249 Psapl1 A NM_001037915 Ripply1 A NM_011187 Psmb7 A NM_001037907 Ripply2 A NM_013585 Psmb9 A NM_009069 Rit1 A NM_025550 Psmd6 A NM_020599 Rlbp1 A NM_011192 Psme3 A NM_201239 Rnase4 A NM_011193 Pstpip1 A NM_027187 Rnaseh2a A NM_001093750 Ptchd1 A NM_009708 Rnd2 A NM_008960 Pten A NM_001033135 Rnf149 A NM_001136079 Ptger4 A NM_021313 Rnf25 A NM_008966 Ptgfr A NM_001099632 Rnf39 A NM_008967 Ptgir A NM_133185 Rogdi A NM_011198 Ptgs2 A NM_013762 Rpl3 A IgH and Myc NM_011199 Pth1r A NM_025589 Rpl36al A NM_175168 Ptk7 A NM_148945 Rps6ka3 A

10

NM_026830 Rreb1 A NM_001077595 Shroom3 A NM_009104 Rrm2 A NM_009174 Siah2 A NM_199476 Rrm2b A NM_153056 Sirt7 A NM_172684 Rsbn1 A NM_011381 Six3 A NM_025546 Rsl1d1 A NM_011382 Six4 A NM_138683 Rspo1 A NM_011385 Ski A NM_025822 Rsrc1 A NM_013730 Slamf1 A NM_153457 Rtn1 A NM_009193 Slbp A NM_022982 Rtn4r A NM_133649 Slc12a6 A NM_177708 Rtn4rl1 A NM_021301 Slc15a2 A NM_199223 Rtn4rl2 A NM_001114332 Slc16a10 A NM_177652 Ryr3 A NM_172838 Slc16a12 A NM_011310 S100a3 A NM_009197 Slc16a2 A NM_013650 S100a8 A NM_153054 Slc18a1 A NM_009114 S100a9 A NM_015747 Slc20a1 A NM_029036 S100pbp A NM_019723 Slc22a21 A NM_001081159 S100z A NM_001033167 Slc22a23 A NM_009117 Saa1 A NM_019687 Slc22a4 A NM_172809 Sacs A NM_011396 Slc22a5 A NM_201395 Sall4 A NM_011397 Slc23a1 A NM_001081415 Samd1 A NM_194333 Slc23a3 A NM_177225 Samd12 A NM_025877 Slc25a23 A NM_011319 Sars A NM_133668 Slc25a3 A NM_175155 Sash1 A NM_007451 Slc25a5 A NM_009122 Satb1 A IgH NM_174870 Slc26a1 A NM_139146 Satb2 A NM_145947 Slc26a7 A NM_011886 Scamp3 A NM_022317 Slc28a3 A NM_029825 Scfd1 A NM_001102415 Slc2a9 A NM_009129 Scg2 A NM_009579 Slc30a1 A NM_026563 Sdccag3 A NM_001033286 Slc30a10 A NM_177879 Sdk1 A NM_011774 Slc30a4 A NM_138741 Sdpr A NM_023214 Slc30a7 A NM_001127725 Sec14l5 A NM_025286 Slc31a2 A NM_001159986 Sec16b A NM_011402 Slc34a2 A NM_026969 Sec31a A NM_080854 Slc34a3 A NM_011346 Sell A NM_029875 Slc35e3 A NM_001042779 Sema3b A NM_178675 Slc35f1 A NM_011348 Sema3e A NM_175434 Slc35f3 A NM_013658 Sema4a A NM_175121 Slc38a2 A NM_013661 Sema5b A NM_145394 Slc44a3 A NM_018744 Sema6a A NM_033552 Slc4a10 A NM_053102 Sep15 A NM_172830 Slc4a9 A NM_001042614 Sepp1 A NM_145423 Slc5a8 A NM_033144 Sept8 A NM_020049 Slc6a14 A NM_001025371 Serinc4 A NM_172271 Slc6a17 A NM_026535 Serpina12 A NM_009209 Slc6a2 A NM_027971 Serpinb12 A NM_010484 Slc6a4 A NM_009250 Serpini1 A NM_148931 Slc6a5 A NM_026460 Serpini2 A NM_008135 Slc6a9 A NM_018820 Sertad1 A NM_007513 Slc7a1 A NM_021372 Sertad2 A NM_011990 Slc7a11 A NM_144907 Sesn2 A NM_007514 Slc7a2 A NM_175465 Sestd1 A NM_007515 Slc7a3 A NM_028262 Setd3 A NM_177909 Slc9a9 A NM_030241 Setd8 A NM_172658 Slco4c1 A NM_021286 Sez6 A NM_199065 Slitrk1 A NM_001110791 Sf1 A NM_175499 Slitrk6 A NM_175102 Sf3b5 A NM_008542 Smad6 A NM_030207 Sfi1 A NM_011416 Smarca2 A NM_011355 Sfpi1 A NM_007958 Smarcad1 A NM_009144 Sfrp2 A NM_022316 Smoc1 A NM_145841 Sgcz A NM_001160127 Smyd1 A NM_144906 Sgip1 A NM_198214 Snph A NM_001004173 Sgpp2 A NM_009227 Snrpe A NM_018825 Sh2b2 A NM_016667 Sntb1 A NM_008507 Sh2b3 A NM_001110311 Snx12 A NM_015825 Sh3bgr A NM_029068 Snx16 A NM_001082414 Sh3d19 A NM_028874 Snx19 A NM_019535 Sh3gl2 A NM_172468 Snx30 A NM_001135728 Sh3kbp1 A NM_009896 Socs1 A IgH NM_001113373 Shank2 A NM_138657 Socs7 A NM_001113331 Shc1 A NM_172752 Sorbs2 A NM_001034874 Shisa6 A NM_011366 Sorbs3 A NM_028277 Shisa9 A NM_011436 Sorl1 A

11

NM_025312 Sostdc1 A NM_001004468 Tacc2 A NM_009233 Sox1 A NM_025444 Taf13 A NM_009234 Sox11 A NM_027427 Taf15 A NM_011438 Sox12 A NM_001081092 Taf4a A NM_009236 Sox18 A NM_001001176 Taf9b A NM_011443 A NM_181071 Tanc2 A NM_009238 Sox4 A NM_001161730 Tap1 A NM_011444 Sox5 A NM_033074 Tars A NM_001025559 Sox6 A NM_031867 Tas1r1 A NM_001098425 Sp3 A NM_031873 Tas1r2 A NM_001025430 Spag9 A NM_031872 Tas1r3 A NM_029343 Spata9 A NM_001033463 Tatdn2 A NM_001029936 Specc1 A NM_181516 Taz A NM_145531 Spg11 A NM_198664 Tbc1d2 A NM_019866 Spib A NM_194334 Tbc1d2b A NM_146043 Spin1 A NM_025935 Tbc1d7 A NM_001076554 Spna2 A NM_018775 Tbc1d8 A NM_153060 Spns2 A NM_173038 Tbcel A NM_025287 Spop A NM_009322 Tbr1 A NM_029269 Spp2 A NM_011532 Tbx1 A NM_011898 Spry4 A NM_032005 Tbx19 A NM_175318 Spty2d1 A NM_011538 Tbx6 A NM_018873 Srcin1 A NM_001083967 Tcf4 A NM_001081037 Srgap1 A NM_009331 Tcf7 A NM_080448 Srgap3 A NM_001122948 Tcfap2a A NM_175347 Srl A NM_009335 Tcfap2c A NM_025527 Srp19 A NM_031182 Tcfap4 A NM_026989 Srsf11 A NM_133986 Tcta A NM_011358 Srsf2 A NM_011562 Tdgf1 A NM_001079695 Srsf5 A NM_001002241 Tdrd1 A NM_146083 Srsf7 A NM_153484 Tef A NM_023672 Ssbp3 A NM_146151 Tesk2 A NM_177710 Ssh2 A NM_009368 Tgfb3 A NM_010656 Sspn A NM_009372 Tgif1 A NM_009217 Sstr2 A NM_001145929 Thap3 A NM_011176 St14 A NM_146153 Thrap3 A NM_173868 St18 A NM_019576 Thsd1 A NM_009183 St8sia4 A NM_172485 Thsd7b A NM_153124 St8sia5 A NM_009382 Thy1 A NM_009282 Stag1 A NM_145976 Tifab A NM_019667 Stam2 A NM_013898 Timm8a1 A NM_145934 Stap2 A NM_011594 Timp2 A NM_213659 Stat3 A NM_012033 Tinag A NM_011489 Stat5b A NM_023476 Tinagl1 A NM_009285 Stc1 A NM_009386 Tjp1 A NM_054098 Steap4 A NM_028927 Tktl2 A NM_009288 Stk10 A NM_009390 Tll1 A NM_133810 Stk17b A NM_011604 Tlr6 A NM_021302 Stk32c A NM_027194 Tm2d2 A NM_001038635 Stk35 A NM_178874 Tmcc2 A NM_175031 Stk36 A NM_026211 Tmed9 A NM_001145827 Stk40 A NM_029912 Tmem116 A NM_019675 Stmn4 A NM_001039723 Tmem120b A NM_023231 Stoml2 A NM_175408 Tmem139 A NM_001162479 Stra6 A NM_197986 Tmem140 A NM_001039878 Strn4 A NM_001081198 Tmem182 A NM_172675 Stx16 A NM_177056 Tmem198 A NM_009294 Stx4a A NM_001081283 Tmem28 A NM_133354 Sumo2 A NM_028975 Tmem33 A NM_001109753 Sv2b A NM_019631 Tmem45a A NM_001003952 Sval3 A NM_025382 Tmem57 A NM_153399 Syne1 A NM_177601 Tmem60 A NM_080451 Synpo2 A NM_026436 Tmem86a A NM_001163032 Synpr A NM_016963 Tmod3 A NM_013635 Sypl A NM_016712 Tmod4 A NM_001114116 Syt3 A NM_145403 Tmprss4 A NM_031393 Sytl1 A NM_001039392 Tmsb10 A NM_001040087 Sytl2 A NM_021278 Tmsb4x A NM_001009574 Taar5 A NM_177368 Tmtc2 A NM_001010830 Taar8a A NM_009397 Tnfaip3 A NM_001010837 Taar8b A NM_134131 Tnfaip8 A NM_001010840 Taar8c A NM_019418 Tnfsf14 A NM_009311 Tac1 A NM_177371 Tnfsf15 A NM_053093 Tac4 A NM_009394 Tnnc2 A

12

NM_001048267 Tnpo1 A NM_172538 Vezt A NM_022312 Tnr A NM_001039385 Vgf A NM_009427 Tob1 A NM_009509 Vil1 A NM_001024206 Trappc1 A NM_134225 Vmn1r193 A NM_144549 Trib1 A NM_134223 Vmn1r195 A NM_030706 Trim2 A NM_134224 Vmn1r202 A NM_030219 Trim42 A NM_001045544 Vmn1r204 A NM_194343 Trim45 A NM_134245 Vmn1r216 A NM_021447 Trim54 A NM_001083311 Vmn1r223 A NM_181853 Trim66 A NM_001013607 Vmo1 A NM_001042503 Trim71 A NM_173028 Vps13a A NM_001024716 Triobp A NM_030559 Vps16 A NM_019797 Trip4 A NM_001004436 Wapal A NM_028604 Trmt11 A NM_153423 Wasf2 A NM_026642 Trmt12 A NM_027149 Wdr20a A NM_013835 Trove2 A NM_026789 Wdr65 A NM_013735 Trp53bp1 A NM_001014981 Wdr7 A NM_001024920 Trp53i13 A NM_029896 Wdr82 A NM_178111 Trp53inp2 A NM_181819 Wfikkn2 A NM_001039104 Trpm1 A NM_175638 Wnk4 A NM_177341 Trpm3 A NM_009521 Wnt3 A NM_001003405 Try5 A NM_009526 Wnt6 A NM_001081229 Tsc22d2 A NM_170779 Wwc1 A NM_031998 Tsga14 A NM_133784 Wwtr1 A NM_011648 Tshr A NM_013842 Xbp1 A IgH NM_025359 Tspan13 A NM_001083919 Xirp2 A NM_145928 Tspan14 A NM_001011874 Xkr4 A NM_020286 Tspan32 A NM_020506 Xpo4 A NM_146173 Tspan33 A NM_023045 Xpo7 A NM_146010 Tspan8 A NM_134151 Yars A NM_029596 Tssk4 A NM_026940 Ydjc A NM_009437 Tst A NM_001005342 Ypel4 A NM_183106 Ttc17 A NM_027166 Ypel5 A NM_027238 Ttc39b A NM_001145919 Ythdf3 A NM_001080949 Ttc5 A NM_178744 Zbtb1 A NM_001033149 Ttc9 A NM_001033466 Zbtb2 A NM_027412 Ttc9c A NM_028356 Zbtb25 A NM_172799 Ttll6 A NM_133759 Zbtb3 A NM_023716 Tubb2b A NM_020256 Zbtb33 A NM_134024 Tubg1 A NM_001085507 Zbtb34 A NM_134028 Tubg2 A NM_029348 Zbtb4 A NM_011656 Tuft1 A NM_001081016 Zc3h7b A NM_134105 Txndc11 A NM_001101433 Zcchc24 A NM_145367 Txndc5 A NM_001037762 Zdhhc12 A NM_023719 Txnip A NM_028031 Zdhhc13 A NM_011664 Ubb A NM_172465 Zdhhc9 A NM_019639 Ubc A NM_011546 Zeb1 A NM_009458 Ube2b A NM_015753 Zeb2 A NM_144839 Ube2e2 A NM_022985 Zfand6 A NM_172300 Ube2z A NM_030708 Zfhx4 A NM_009461 Ubr1 A NM_030713 Zfp202 A NM_001160319 Ubr4 A NM_013889 Zfp292 A NM_011551 Ubtf A NM_011756 Zfp36 A NM_019562 Uchl5 A NM_007564 Zfp36l1 A IgH NM_030724 Uck2 A NM_001001806 Zfp36l2 A NM_031250 Ucn3 A NM_199029 Zfp395 A NM_011671 Ucp2 A NM_001146024 Zfp444 A NM_011672 Ufd1l A NM_001013777 Zfp488 A NM_001111078 Uhrf1 A NM_183033 Zfp516 A NM_009469 Ulk1 A NM_207255 Zfp532 A NM_013881 Ulk2 A NM_172385 Zfp536 A NM_009470 Umod A NM_175751 Zfp608 A NM_001009573 Unc13d A NM_009564 Zfp64 A NM_146144 Usp1 A NM_173769 Zfp641 A NM_144937 Usp3 A NM_001040686 Zfp692 A NM_001033173 Usp31 A NM_026521 Zfp706 A NM_130879 Usp48 A NM_153194 Zfp740 A NM_198421 Usp49 A NM_178763 Zfp750 A NM_133857 Usp53 A NM_001081382 Zfp777 A NM_181399 Usp6nl A NM_001081678 Zfp800 A NM_030132 Utp23 A NM_025884 Zfp830 A NM_178635 Uvrag A NM_022987 Zic5 A NM_146139 Vav3 A NM_001039115 Zkscan4 A NM_145820 Veph1 A NM_029498 Zmym2 A

13

NM_019831 Zmym3 A NM_183256 2310016M24Rik B NM_001033196 Znfx1 A NM_001159583 2310028H24Rik B NM_011775 Zp2 A NM_025865 2310030G06Rik B NM_207302 Zranb1 A NM_001037143 2310033E01Rik B NM_026676 0610007P22Rik B NM_024210 2310033P09Rik B NM_025319 0610009B22Rik B NM_026336 2310057J18Rik B NM_026686 0610011F06Rik B NM_001033630 2310061I04Rik B NM_026696 0610030E20Rik B NM_025605 2400001E08Rik B NM_020003 0610031J06Rik B NM_001093759 2410002O22Rik B NM_183275 1110002N22Rik B NM_028033 2410012M07Rik B NM_028865 1110005A03Rik B NM_153152 2410015M20Rik B NM_025373 1110008L16Rik B NM_023633 2410016O06Rik B NM_001114098 1110012J17Rik B NM_001081236 2410131K14Rik B NM_028624 1110017D15Rik B NM_023215 2500003M10Rik B NM_183116 1110021L09Rik B NM_001033164 2510002D24Rik B NM_177645 1110028C15Rik B NM_026312 2610029G23Rik B NM_023483 1110032A03Rik B NM_027001 2610034M16Rik B NM_027269 1110034A24Rik B IgH NM_183287 2610318N02Rik B NM_026503 1110058L19Rik B NM_178115 2700050L05Rik B NM_001033145 1190002N15Rik B NM_026528 2700060E02Rik B NM_024262 1200011M11Rik B NM_028310 2810006K23Rik B NM_025831 1300014I06Rik B NM_001048250 2810008M24Rik B NM_027905 1300018J18Rik B NM_173382 2810046L04Rik B NM_024283 1500015O10Rik B NM_027419 2810408A11Rik B NM_026914 1500032L24Rik B NM_026515 2810417H13Rik B NM_026547 1520402A15Rik B NM_026050 2810453I06Rik B NM_025904 1600012F09Rik B NM_028377 2900006K08Rik B NM_001083880 1600012H06Rik B NM_144518 2900011O08Rik B NM_001085385 1600014C10Rik B NM_028440 3110003A17Rik B NM_028479 1600027N09Rik B NM_026077 3110040N11Rik B NM_029639 1600029D21Rik B NM_001081343 3110043O21Rik B NM_198000 1700001O22Rik B NM_175195 3110056O03Rik B NM_028156 1700001P01Rik B NM_027532 3200002M19Rik B NM_027952 1700008I05Rik B NM_028732 4632428N05Rik B NM_025490 1700010M22Rik B NM_172500 4831426I19Rik B NM_029372 1700011F14Rik B NM_026127 4833420G17Rik B NM_001033162 1700012A16Rik B NM_177702 4833427G06Rik B NM_027056 1700012P22Rik B NM_001081154 4921513D23Rik B NM_029314 1700013F07Rik B NM_026338 4921517D21Rik B NM_027077 1700016C15Rik B NM_027585 4921517L17Rik B NM_001081246 1700017N19Rik B NM_001081029 4930420K17Rik B NM_029601 1700019E19Rik B NM_024273 4930455C21Rik B NM_025619 1700019L03Rik B NM_030047 4930458L03Rik B NM_001039494 1700019N12Rik B NM_001114312 4930506M07Rik B NM_025492 1700020L24Rik B NM_026290 4930511I11Rik B NM_183254 1700025K23Rik B NM_199023 4930526D03Rik B NM_029335 1700026D08Rik B NM_175280 4930529M08Rik B NM_001033148 1700029J07Rik B NM_026652 4930547C10Rik B NM_030097 1700034E13Rik B NM_026296 4930548H24Rik B NM_028494 1700034I23Rik B NM_029247 4930550C14Rik B NM_029671 1700034O15Rik B NM_029252 4930563D23Rik B NM_028505 1700040I03Rik B NM_001033807 4930567H17Rik B NM_026099 1700065I17Rik B NM_027089 4930579C15Rik B NM_030104 1700090G07Rik B NM_029464 4930588N13Rik B NM_026105 1700093K21Rik B NM_198668 4930590J08Rik B NM_028576 1700106N22Rik B NM_177676 4931409K22Rik B NM_021437 1700123O20Rik B NM_027633 4931417G12Rik B NM_025463 1810009A15Rik B NM_028888 4931428F04Rik B NM_023707 1810009J06Rik B NM_172534 4932411E22Rik B NM_001076681 1810012P15Rik B NM_175368 4933402P03Rik B NM_026982 1810027O10Rik B NM_153794 4933403F05Rik B NM_175141 1810030O07Rik B NM_025744 4933404M02Rik B NM_026977 1810031K17Rik B NM_027655 4933405L10Rik B NM_026958 1810035L17Rik B NM_028914 4933406J08Rik B NM_026431 1810043G02Rik B NM_177773 4933408B17Rik B NM_028077 1810055G02Rik B NM_025752 4933411K16Rik B NM_134133 2010002N04Rik B NM_178682 4933426M11Rik B NM_026333 2010106E10Rik B NM_177607 4933430I17Rik B NM_027363 2010110P09Rik B NM_028961 4933433C11Rik B NM_028079 2010111I01Rik B NM_001033304 5330417C22Rik B NM_027977 2310001A20Rik B NM_001160363 5430405G05Rik B NM_026415 2310002J15Rik B NM_001142698 5730494M16Rik B NM_001081226 2310009B15Rik B NM_027478 5730494N06Rik B NM_023516 2310016C08Rik B NM_028872 5730559C18Rik B

14

NM_178243 5830403L16Rik B NM_007387 Acp2 B NM_183264 5830405N20Rik B NM_001102404 Acp5 B NM_177854 6030405A18Rik B NM_153420 Acpl2 B NM_183126 6030498E09Rik B NM_053178 Acsbg1 B NM_175234 6230409E13Rik B NM_001033599 Acsl6 B NM_026597 6230427J02Rik B NM_054094 Acsm1 B NM_134022 6330403K07Rik B NM_080575 Acss1 B NM_026138 6330407J23Rik B NM_175497 Actbl2 B NM_177312 6330408A02Rik B NM_021895 Actn4 B NM_144905 6330416G13Rik B NM_019785 Actr10 B NM_029530 6330527O06Rik B NM_023735 Actr3 B NM_001145352 6430550D23Rik B NM_175419 Actr5 B NM_175486 6430571L13Rik B NM_027493 Actr8 B NM_175521 6430598A04Rik B NM_007396 Acvr2a B NM_001142965 6430704M03Rik B NM_009612 Acvrl1 B NM_133937 6720456B07Rik B NM_009350 Adad1 B NM_177793 9030224M15Rik B NM_007399 Adam10 B NM_198296 9130011E15Rik B NM_007400 Adam12 B NM_030226 9130019O22Rik B NM_009614 Adam15 B NM_177001 9130023H24Rik B NM_001048175 Adam28 B NM_172706 9330182L06Rik B NM_175939 Adam29 B NM_175417 9530008L14Rik B NM_007402 Adam7 B NM_177003 9630033F20Rik B NM_007403 Adam8 B NM_172641 9930023K05Rik B NM_172619 Adamts10 B NM_001081074 A1cf B NM_001024139 Adamts15 B NM_001033375 A230046K03Rik B NM_001033877 Adamts17 B NM_175687 A230050P20Rik B NM_172466 Adamts18 B NM_175628 A2m B NM_011782 Adamts5 B NM_001163019 A430005L14Rik B NM_001081020 Adamts6 B NM_170757 A630007B06Rik B NM_175314 Adamts9 B NM_001004174 AA467197 B NM_029967 Adamtsl1 B NM_023383 Aadac B NM_001038587 Adar B NM_001128091 Aadacl2 B NM_013925 Adat1 B NM_025857 Aagab B NM_025748 Adat2 B NM_146110 Aamp B NM_172875 Adc B NM_009591 Aanat B NM_178873 Adck2 B NM_175503 Aard B NM_009622 Adcy1 B NM_146217 Aars B NM_173029 Adcy10 B NM_026276 Aasdhppt B NM_153534 Adcy2 B NM_013930 Aass B NM_080435 Adcy4 B NM_019816 Aatf B NM_001012765 Adcy5 B NM_013454 Abca1 B NM_001109756 Adcy7 B NM_026458 Abca14 B NM_009625 Adcyap1 B NM_007379 Abca2 B NM_007409 Adh1 B NM_001039581 Abca3 B NM_007410 Adh5 B NM_147218 Abca6 B NM_175236 Adhfe1 B NM_153145 Abca8a B NM_145635 Adig B NM_011076 Abcb1a B NM_009605 Adipoq B NM_023732 Abcb6 B NM_009627 Adm B NM_013806 Abcc2 B NM_009628 Adnp B NM_029600 Abcc3 B NM_001005419 Ado B NM_007435 Abcd1 B NM_009631 Adora3 B NM_011994 Abcd2 B NM_133883 Adprhl2 B NM_008991 Abcd3 B NM_013461 Adra1a B NM_138955 Abcg4 B NM_007419 Adrb1 B NM_031884 Abcg5 B NM_019822 Adrm1 B NM_026180 Abcg8 B NM_027373 Afap1 B NM_172511 Abhd10 B NM_178928 Afap1l1 B NM_183181 Abhd16b B NM_133919 Aff1 B NM_025659 Abi3 B NM_008032 Aff2 B NM_178790 Abi3bp B NM_001037136 Agap1 B NM_001103178 Ablim1 B NM_178630 Agbl3 B NM_177678 Ablim2 B NM_174849 Agbl5 B NM_198895 Abr B NM_026644 Agpat4 B NM_030251 Abtb1 B NM_207531 Agr3 B NM_133360 Acaca B NM_001048008 Agtpbp1 B NM_017366 Acadvl B NM_007429 Agtr2 B NM_153151 Acat3 B NM_016702 Agxt B NM_009597 Accn2 B NM_001031851 Agxt2 B NM_175731 Acer1 B NM_021414 Ahcyl2 B NM_001085473 Acin1 B NM_001039959 Ahnak B NM_145368 Acnat2 B NM_013465 Ahsg B NM_019736 Acot9 B NM_172381 AI314180 B NM_053115 Acox2 B NM_001160356 AI462493 B

15

NM_001013028 AI597468 B NM_007456 Ap1m1 B NM_133818 AI597479 B NM_001077264 Ap2a1 B NM_001033199 AI747448 B NM_009679 Ap2m1 B NM_145144 Aif1l B NM_021492 Ap3b2 B NM_153779 Aifm2 B NM_026193 Ap4b1 B NM_146165 Aimp2 B NM_175550 Ap4e1 B NM_001045524 AK129341 B NM_021392 Ap4m1 B NM_009648 Akap1 B NM_001042558 Apaf1 B NM_031185 Akap12 B NM_133237 Apcdd1 B NM_029332 Akap13 B NM_146226 Apeh B NM_001101471 Akap5 B NM_009687 Apex1 B NM_017476 Akap8l B NM_029943 Apex2 B NM_194462 Akap9 B NM_013474 Apoa2 B NM_001007589 Akirin2 B NM_009693 Apob B NM_029901 Akr1c21 B NM_138310 Apobr B NM_145364 Akr1d1 B NM_013475 Apoh B NM_026270 Akt1s1 B NM_133996 Apon B NM_011785 Akt3 B NM_016689 Aqp3 B NM_020559 Alas1 B NM_022026 Aqp9 B NM_009654 Alb B NM_009702 Aqr B NM_053080 Aldh1a3 B NM_139206 Arap3 B NM_027406 Aldh1l1 B NM_007480 Arf5 B NM_026316 Aldh3b1 B NM_145760 Arfgap1 B NM_175438 Aldh4a1 B NM_023854 Arfgap2 B NM_019993 Aldh9a1 B NM_007482 Arg1 B NM_007438 Aldoa B NM_001145902 Arhgap1 B NM_009657 Aldoc B NM_175535 Arhgap20 B NM_025442 Alg5 B NM_146161 Arhgap24 B NM_001102565 Alkbh1 B NM_178252 Arhgap33 B NM_175016 Alkbh2 B NM_001162423 Arhgap4 B NM_172943 Alkbh5 B NM_133796 Arhgdia B NM_145223 Alms1 B NM_008488 Arhgef1 B NM_009659 Alox12b B NM_177566 Arhgef15 B NM_145684 Alox12e B NM_001081116 Arhgef17 B NM_009662 Alox5 B NM_172520 Arhgef19 B NM_009663 Alox5ap B NM_008487 Arhgef2 B NM_011786 Aloxe3 B NM_028027 Arhgef25 B NM_054085 Alpk3 B NM_001145452 Arhgef33 B NM_001033449 Als2cr4 B NM_183019 Arhgef4 B NM_007441 Alx3 B NM_133674 Arhgef5 B NM_019871 Amac1 B NM_001080819 Arid1a B NM_009664 Ambn B NM_007880 Arid3a B NM_172935 Amdhd2 B NM_001081195 Arid4a B NM_001081978 Amelx B NM_019968 Arl10 B NM_001005421 Amica1 B NM_019722 Arl2 B NM_153515 Ammecr1l B NM_182994 Arl5a B NM_019764 Amotl2 B NM_207231 Arl5c B NM_001033303 Ampd1 B NM_146205 Armc5 B NM_001038230 Anapc11 B NM_177778 Armc7 B NM_175300 Anapc2 B NM_028768 Armc8 B NM_001161731 Ang B NM_027870 Armcx3 B NM_007426 Angpt2 B NM_001007578 Armcx6 B NM_028333 Angptl1 B NM_007488 Arnt2 B NM_020581 Angptl4 B NM_007489 Arntl B NM_145154 Angptl6 B NM_026369 Arpc5 B NM_001039554 Angptl7 B NM_028809 Arpc5l B NM_031158 Ank1 B NM_001042591 Arrdc3 B NM_001080933 Ankfn1 B NM_001042592 Arrdc4 B NM_009671 Ankfy1 B NM_029799 Arrdc5 B NM_175375 Ankhd1 B NM_009712 Arsb B NM_023472 Ankra2 B NM_026639 Art4 B NM_026720 Ankrd13d B NM_026855 Arv1 B NM_027480 Ankrd24 B NM_007492 Arx B NM_144790 Ankrd33 B NM_001008232 Asap3 B NM_001024851 Ankrd34a B NM_025758 Asb17 B NM_207260 Ankrd34c B NM_139152 Asb18 B NM_001012450 Ankrd6 B NM_029569 Asb5 B NM_025732 Ankrd61 B NM_020051 Ascl3 B NM_153589 Ano2 B NM_009714 Asgr1 B NM_001081556 Ano3 B NM_026690 Aspdh B NM_175344 Ano6 B NM_026487 Atad1 B NM_009672 Anp32a B NM_027435 Atad2 B NM_010730 Anxa1 B NM_179203 Atad3a B NM_012054 Aoah B NM_028476 Atat1 B

16

NM_007498 Atf3 B NM_001142968 BC024139 B NM_146065 Atf7 B NM_001135577 BC024659 B NM_025770 Atg10 B NM_173411 BC030500 B NM_178628 Atl1 B NM_153544 BC030867 B NM_007881 Atn1 B NM_001113283 BC031353 B NM_153778 Atoh8 B NM_001100452 BC032203 B NM_176999 Atp10b B NM_183143 BC048679 B NM_175650 Atp13a5 B NM_001127685 BC048943 B NM_144921 Atp1a3 B NM_001110506 BC060267 B NM_013415 Atp1b2 B NM_001009951 BC088983 B NM_213616 Atp2b4 B NM_172521 BC125332 B NM_007507 Atp5k B NM_007529 Bcan B NM_025504 Atp5sl B NM_012060 Bcap31 B NM_001145879 Atp6ap1l B NM_029236 Bcdin3d B NM_027439 Atp6ap2 B NM_007533 Bckdha B NM_016920 Atp6v0a1 B NM_007534 Bcl2a1b B NM_025272 Atp6v0e B NM_007536 Bcl2a1d B NM_133764 Atp6v0e2 B NM_007537 Bcl2l2 B NM_007508 Atp6v1a B NM_007528 Bcl6b B NM_134157 Atp6v1b1 B NM_025784 Bcs1l B NM_024173 Atp6v1g1 B NM_007539 Bdkrb1 B NM_023179 Atp6v1g2 B NM_001048142 Bdnf B NM_001081182 Atp8b2 B NM_001130193 Best2 B NM_001080944 Atp8b4 B NM_001162937 Bet3l B NM_177195 Atp8b5 B NM_009052 Bex1 B NM_181040 Atpaf1 B NM_007542 Bgn B NM_001033436 Atxn7l1 B NM_177182 Bhlha9 B NM_001033474 Atxn7l3b B NM_198161 Bhlhb9 B NM_001012400 AU022252 B NM_009668 Bin1 B NM_007517 Aup1 B NM_016916 Blcap B NM_011496 Aurkb B NM_007549 Blk B NM_177047 Auts2 B NM_007552 Bmi1 B NM_028844 Aven B NM_009756 Bmp10 B NM_009635 Avil B NM_007553 Bmp2 B NM_027106 Avpi1 B NM_007554 Bmp4 B NM_001104646 AW209491 B NM_007555 Bmp5 B NM_001033532 AW554918 B NM_007560 Bmpr1b B NM_015732 Axin2 B NM_007561 Bmpr2 B NM_009465 Axl B NM_009759 Bmx B NM_026592 B230118H07Rik B NM_172506 Boc B NM_023057 B230120H23Rik B NM_175103 Bola2 B NM_001024616 B230208H17Rik B NM_026512 Bphl B NM_001080935 B230217C12Rik B NM_008953 Bpifa2e B NM_172691 B230312A22Rik B NM_025990 Bpifa5 B NM_001081204 B3galtl B NM_025631 Bpifb2 B NM_029792 B3gat1 B NM_139294 Braf B NM_024256 B3gat3 B NM_009764 Brca1 B NM_001081167 B3gnt6 B NM_030147 Brd8 B NM_178879 B3gnt9-ps B NM_001024508 Brd9 B NM_022305 B4galt1 B NM_025686 Brf2 B NM_020579 B4galt3 B NM_178309 Brip1 B NM_146045 B4galt7 B NM_001037756 Brms1l B NM_175312 B630005N14Rik B NM_030178 Brpf1 B NM_172148 B9d2 B NM_001003920 Brsk1 B NM_080640 Baalc B NM_001081477 Brwd3 B NM_011792 Bace1 B NM_001136064 Bscl2 B NM_019517 Bace2 B NM_007567 Bsn B NM_001109661 Bach2 B NM_178245 Bsx B NM_026121 Bag4 B NM_133700 Btbd10 B NM_027088 Bap1 B NM_172806 Btbd7 B NM_007525 Bard1 B NM_145455 Btf3 B NM_007527 Bax B NM_009770 Btg3 B NM_013815 Baz1a B NM_001008705 Bud31 B NM_011714 Baz1b B NM_016859 Bysl B NM_026116 Bbs2 B NM_172449 Bzrap1 B NM_027810 Bbs7 B NM_177075 C030019I05Rik B NM_030252 BC003266 B NM_172730 C130022K22Rik B NM_145511 BC003331 B NM_175219 C130026I21Rik B NM_144885 BC005624 B NM_175524 C130060K24Rik B NM_145389 BC016579 B NM_177661 C130079G13Rik B NM_145430 BC017647 B NM_020558 C1d B NM_144927 BC019943 B NM_021550 C1galt1c1 B NM_145536 BC020535 B NM_007573 C1qbp B NM_001033328 BC023829 B NM_028331 C1qtnf6 B

17

NM_001135172 C1qtnf7 B NM_025689 Ccdc51 B NM_183175 C1qtnf9 B NM_027046 Ccdc54 B NM_144938 C1s B NM_001159421 Ccdc58 B NM_172924 C230081A13Rik B NM_177759 Ccdc60 B NM_001039200 C230096C10Rik B NM_001033314 Ccdc61 B NM_009778 C3 B NM_001134767 Ccdc62 B NM_175319 C330005M16Rik B NM_183250 Ccdc72 B NM_011413 C4a B NM_207268 Ccdc87 B NM_009780 C4b B NM_029955 Ccdc93 B NM_007576 C4bp B NM_025725 Ccdc96 B NM_016704 C6 B NM_001002787 Ccin B NM_144532 Cabp4 B NM_031161 Cck B NM_138948 Cabp7 B NM_011329 Ccl1 B NM_007578 Cacna1a B NM_011331 Ccl12 B NM_009782 Cacna1e B NM_172301 Ccnb1 B NM_019582 Cacna1f B NM_009831 Ccng1 B NM_145121 Cacnb1 B NM_172839 Ccnj B NM_001037099 Cacnb4 B NM_207678 Ccnl2 B NM_007582 Cacng1 B NM_009912 Ccr1 B NM_019431 Cacng4 B NM_007721 Ccr10 B NM_080644 Cacng5 B NM_009916 Ccr4 B NM_023525 Cad B NM_017466 Ccrl2 B NM_018782 Calcrl B NM_016892 Ccs B NM_145575 Cald1 B NM_009837 Cct4 B NM_001081271 Calhm1 B NM_007638 Cct7 B NM_133746 Calhm2 B NM_001099332 Cd101 B NM_027416 Calml3 B NM_009841 Cd14 B NM_001102468 Calml4 B NM_008533 Cd180 B NM_009921 Camp B NM_021325 Cd200r1 B NM_001115076 Camsap1 B NM_018729 Cd244 B NM_027994 Cand1 B NM_001042564 Cd27 B NM_025958 Cand2 B NM_021893 Cd274 B NM_029502 Cant1 B NM_172050 Cd300e B NM_001013767 Capn11 B NM_001159556 Cd36 B NM_016739 Caprin1 B NM_007645 Cd37 B NM_009797 Capza1 B NM_013706 Cd52 B NM_007605 Capza3 B NM_007651 Cd53 B NM_001083957 Car1 B NM_010016 Cd55 B NM_030558 Car15 B NM_009853 Cd68 B NM_013742 Cars B NM_009855 Cd80 B NM_145398 Casd1 B NM_138309 Cd99l2 B NM_009814 Casq2 B NM_027986 Cdadc1 B NM_001080820 Cass4 B NM_026891 Cdan1 B NM_029772 Catsper3 B NM_009860 Cdc25c B NM_001033238 Cblb B NM_145436 Cdc27 B NM_019626 Cbln1 B NM_133974 Cdcp1 B NM_172633 Cbln2 B NM_009865 Cdh10 B NM_145595 Cbr4 B NM_001081386 Cdh19 B NM_146097 Cbwd1 B NM_011800 Cdh20 B NM_007624 Cbx3 B NM_199470 Cdh24 B NM_028634 Cby1 B NM_198656 Cdh26 B NM_172274 Cc2d2a B NM_007666 Cdh6 B NM_026201 Ccar1 B NM_146239 Cdk17 B NM_172404 Ccbl1 B NM_198164 Cdk19 B NM_001033533 Ccdc102a B NM_007668 Cdk5 B NM_001033259 Ccdc109a B NM_009871 Cdk5r1 B NM_028312 Ccdc12 B NM_030248 Cdk5rap3 B NM_183115 Ccdc125 B NM_153599 Cdk8 B NM_024260 Ccdc132 B NM_016912 Cdkl2 B NM_001042715 Ccdc135 B NM_009875 Cdkn1b B NM_001162956 Ccdc138 B NM_001008424 Cdsn B NM_001081369 Ccdc153 B NM_001134427 Cdv3 B NM_177616 Ccdc157 B NM_009880 Cdx1 B NM_177230 Ccdc158 B NM_007674 Cdx4 B NM_001037916 Ccdc17 B NM_009883 Cebpb B NM_138603 Ccdc22 B NM_007679 Cebpd B NM_025455 Ccdc28b B NM_207131 Cebpe B NM_028804 Ccdc3 B NM_009884 Cebpg B NM_029286 Ccdc30 B NM_001110232 Celf2 B NM_199310 Ccdc32 B NM_175235 Celf6 B NM_026613 Ccdc34 B NM_021316 Cend1 B NM_175430 Ccdc40 B NM_001081363 Cenpf B NM_145688 Ccdc46 B NM_021886 Cenph B NM_026009 Ccdc47 B NM_145924 Cenpi B

18

NM_134046 Cenpo B NM_029738 Cluap1 B NM_001081091 Cep152 B NM_029556 Clybl B NM_001099637 Cep170 B NM_026066 Cmtm5 B NM_001129999 Cep250 B NM_007724 Cnga2 B NM_198019 Cep78 B NM_009919 Cnih B NM_145475 Cerk B NM_009920 Cnih2 B NM_001048176 Cerkl B NM_177751 Cnksr2 B NM_144511 Ces3b B NM_001039551 Cnnm3 B NM_019405 Cetn2 B NM_153585 Cnot10 B NM_009888 Cfh B NM_146176 Cnot3 B NM_001025575 Cfhr2 B NM_016877 Cnot4 B NM_007688 Cfl2 B NM_178854 Cnot6l B NM_178647 Cggbp1 B NM_001146318 Cnp B NM_009890 Ch25h B NM_007726 Cnr1 B NM_009891 Chat B NM_029861 Cnrip1 B NM_025366 Chchd1 B NM_146105 Cnst B NM_025336 Chchd3 B NM_001136056 Cntfr B NM_133928 Chchd4 B NM_001159647 Cntn1 B NM_025351 Chchd6 B NM_008779 Cntn3 B NM_146019 Chd3 B NM_001033359 Cntn5 B NM_173368 Chd6 B NM_016782 Cntnap1 B NM_001081417 Chd7 B NM_001081129 Cntnap3 B NM_001136240 Chdh B NM_001077425 Cntnap5a B NM_007691 Chek1 B NM_172851 Cntnap5b B NM_007695 Chi3l1 B NM_007728 Coch B NM_009767 Chic1 B NM_133973 Cog4 B NM_024190 Chmp1b B NM_001163126 Cog5 B NM_026885 Chmp2a B NM_009925 Col10a1 B NM_029362 Chmp4b B NM_009928 Col15a1 B NM_001113246 Chn1 B NM_007732 Col17a1 B NM_023543 Chn2 B NM_009929 Col18a1 B NM_009893 Chrd B NM_007733 Col19a1 B NM_007699 Chrm4 B NM_007742 Col1a1 B NM_001081424 Chrna10 B NM_007743 Col1a2 B NM_007390 Chrna7 B NM_029838 Col25a1 B NM_148944 Chrnb4 B NM_031163 Col2a1 B NM_021600 Chrnd B NM_009930 Col3a1 B NM_009603 Chrne B NM_015734 Col5a1 B NM_175140 Chst8 B NM_007737 Col5a2 B NM_025296 Ciao1 B NM_007738 Col7a1 B NM_001110132 Cic B NM_007739 Col8a1 B NM_009894 Cideb B NM_007740 Col9a1 B NM_026818 Cilp2 B NM_009936 Col9a3 B NM_001085500 Cisd3 B NM_173422 Colec10 B NM_007709 Cited1 B NM_009937 Colq B NM_028412 Ciz1 B NM_178377 Commd10 B NM_001134733 CK137956 B NM_017477 Copg B NM_021273 Ckb B NM_017478 Copg2 B NM_016904 Cks1b B NM_012002 Cops6 B NM_001114347 Clasp2 B NM_172974 Cops7b B NM_016680 Clasrp B NM_019877 Copz2 B NM_030601 Clca2 B NM_001039710 Coq10b B NM_017474 Clca3 B NM_172687 Coq3 B NM_139148 Clca4 B NM_009940 Coq7 B NM_207208 Clca6 B NM_009898 Coro1a B NM_013491 Clcn1 B NM_011778 Coro1b B NM_009900 Clcn2 B NM_139128 Coro6 B NM_007711 Clcn3 B NM_007745 Cort B NM_008770 Cldn11 B NM_028071 Cotl1 B NM_022890 Cldn12 B NM_178379 Cox10 B NM_181490 Cldn17 B NM_009945 Cox7a2 B NM_027998 Cldn23 B NM_007752 Cp B NM_025809 Clec14a B NM_144537 Cpa5 B NM_177562 Clec16a B NM_019775 Cpb2 B NM_001163161 Clec4d B NM_175937 Cpeb2 B NM_019948 Clec4e B NM_146223 Cplx3 B NM_020008 Clec7a B NM_145493 Cplx4 B NM_019765 Clip1 B NM_170673 Cpne9 B NM_175378 Clip4 B NM_007757 Cpox B IgH NM_007713 Clk3 B NM_053193 Cpsf1 B NM_001146311 Cln3 B NM_018813 Cpsf3 B NM_133840 Clp1 B NM_009948 Cpt1b B NM_019649 Clptm1 B NM_027749 Cpvl B NM_001003908 Cltc B NM_019696 Cpxm1 B

19

NM_007759 Crabp2 B NM_001112701 Cyth2 B NM_020608 Cramp1l B NM_001109988 D0H4S114 B NM_177638 Crb3 B NM_145422 D10Wsu52e B NM_013497 Creb3 B NM_025967 D16Ertd472e B NM_198408 Crhbp B NM_172631 D18Ertd653e B NM_007762 Crhr1 B NM_177474 D19Bwg1357e B NM_015800 Crim1 B NM_177464 D19Ertd386e B NM_024223 Crip2 B NM_026412 D2Ertd750e B NM_019936 Cript B NM_001099785 D3Ertd751e B NM_030033 Crisp4 B NM_001025608 D4Ertd22e B NM_007768 Crp B NM_001033385 D630037F22Rik B NM_028881 Crtc2 B NM_001081186 D630042F21Rik B NM_009963 Cry2 B NM_001007571 D8Ertd738e B NM_009965 Cryba1 B NM_020616 D930014E17Rik B NM_021541 Cryba2 B NM_177335 D930020B18Rik B NM_174848 Crybg3 B NM_177259 Dab1 B NM_007774 Cryga B NM_001008702 Dab2 B NM_144761 Crygb B NM_001114124 Dab2ip B NM_007777 Cryge B NM_010045 Darc B NM_016669 Crym B NM_011873 Dazap2 B NM_007780 Csf2rb B NM_021294 Dbil5 B NM_007782 Csf3r B NM_001048227 Dbndd2 B NM_172753 Csgalnact1 B NM_013810 Dbnl B NM_027945 Csl B NM_001005232 Dbx1 B NM_009972 Csn2 B NM_178739 Dcaf12l1 B NM_007786 Csn3 B NM_030246 Dcaf4 B NM_009974 Csnk2a2 B NM_153555 Dcaf8 B NM_009975 Csnk2b B NM_028523 Dcbld2 B NM_181417 Csrp2bp B NM_177577 Dcdc2a B NM_030059 Cst11 B NM_001111053 Dclk1 B NM_146034 Ctage5 B NM_027539 Dclk2 B NM_009980 Ctbp2 B NM_018831 Dclre1a B NM_028836 Ctbs B NM_001025312 Dclre1b B NM_181322 Ctcf B NM_027030 Dcps B NM_153088 Ctdsp1 B NM_010024 Dct B NM_212450 Ctdspl2 B NM_007835 Dctn1 B NM_010217 Ctgf B NM_027151 Dctn2 B NM_009843 Ctla4 B NM_001159565 Dctn3 B NM_009818 Ctnna1 B NM_001024504 Dcun1d2 B NM_001141930 Ctnnbip1 B NM_027942 Ddi1 B NM_008729 Ctnnd2 B NM_007837 Ddit3 B NM_031251 Ctns B NM_029083 Ddit4 B IgH NM_025583 Ctrb1 B NM_022563 Ddr2 B NM_007802 Ctsk B NM_172284 Ddx19b B NM_029636 Ctsq B NM_001080981 Ddx23 B NM_080285 Cttnbp2 B NM_001033294 Ddx31 B NM_001134697 Ctxn3 B NM_019693 Ddx39b B NM_001081084 Cubn B NM_010029 Ddx4 B NM_029402 Cul2 B NM_134059 Ddx41 B NM_007804 Cux2 B NM_028074 Ddx42 B NM_009142 Cx3cl1 B NM_028041 Ddx54 B NM_008176 Cxcl1 B NM_026409 Ddx55 B NM_009141 Cxcl5 B NM_026538 Ddx56 B NM_009910 Cxcr3 B NM_026500 Ddx59 B NM_030712 Cxcr6 B NM_001040461 Dear1 B NM_007805 Cyb561 B NM_001128609 Dedd B NM_001081320 Cyb561d1 B NM_207677 Dedd2 B NM_019720 Cyb561d2 B NM_007853 Degs1 B NM_001024926 Cyb5d2 B NM_028110 Dennd2d B NM_177216 Cyb5r2 B NM_177192 Dennd5b B NM_175471 Cyb5rl B NM_001037937 Deptor B NM_201351 Cybasc3 B NM_010043 Des B NM_007807 Cybb B NM_007859 Dffb B NM_028593 Cybrd1 B NM_010046 Dgat1 B NM_011370 Cyfip1 B NM_026384 Dgat2 B NM_133769 Cyfip2 B NM_001114084 Dgat2l6 B NM_009995 Cyp21a1 B NM_001081633 Dgcr14 B NM_007811 Cyp26a1 B NM_177914 Dgkk B NM_009997 Cyp2a4 B NM_199011 Dgkq B NM_001081148 Cyp2b23 B NM_138306 Dgkz B NM_001001446 Cyp2c44 B NM_001162521 Dguok B NM_145474 Cyp2d34 B NM_007856 Dhcr7 B NM_001100185 Cyp4a30b-ps B NM_026144 Dhdds B NM_010516 Cyr61 B NM_007857 Dhh B

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NM_020046 Dhodh B NM_025777 Duoxa2 B NM_001039514 Dhps B NM_001013826 Dupd1 B NM_183286 Dhrs13 B NM_144858 Dus3l B NM_030686 Dhrs4 B NM_028002 Dus4l B NM_172594 Dhx29 B NM_022019 Dusp10 B NM_178367 Dhx33 B NM_001007268 Dusp13 B NM_027883 Dhx34 B NM_019819 Dusp14 B NM_178380 Dhx38 B NM_001085390 Dusp5 B NM_026191 Dhx40 B NM_008748 Dusp8 B NM_144831 Dhx8 B NM_010091 Dvl1 B NM_145415 Diexf B NM_029851 Dync2h1 B NM_174854 Disc1 B NM_026314 Dyx1c1 B NM_170593 Disp2 B NM_172905 E030002O03Rik B NM_015814 Dkk3 B NM_198299 E130303B06Rik B NM_015802 Dlc1 B NM_001013377 E130306D19Rik B NM_010055 Dlx3 B NM_153158 E130308A19Rik B NM_007867 Dlx4 B NM_172831 E230025N22Rik B NM_010056 Dlx5 B NM_178609 E2f7 B NM_028618 Dmkn B NM_175011 E330017A01Rik B NM_175647 Dmrta1 B NM_007893 B NM_019872 Dmrtb1 B NM_053113 Ear11 B NM_027591 Dmrtc1a B NM_019398 Ear5 B NM_001142691 Dmrtc1c1 B NM_053111 Ear6 B NM_001142690 Dmrtc1c2 B NM_017385 Ear7 B NM_027732 Dmrtc2 B NM_026598 Ebpl B NM_133365 Dnahc5 B NM_027475 Ecd B NM_175138 Dnaic1 B NM_199307 Ece1 B NM_023646 Dnaja3 B NM_021306 Ecel1 B NM_021422 Dnaja4 B NM_016772 Ech1 B NM_139139 Dnajc17 B NM_001161432 Eda2r B NM_176835 Dnajc22 B NM_010103 Edil3 B NM_001033165 Dnajc25 B NM_007903 Edn3 B NM_020566 Dnajc4 B NM_010332 Ednra B NM_010062 Dnase2a B NM_010106 Eef1a1 B NM_019957 Dnase2b B NM_026007 Eef1g B NM_001038619 Dnm3 B NM_026626 Efcab2 B NM_153743 Dnmt3a B NM_001025103 Efcab4a B NM_001043228 Dntt B NM_029946 Efcab6 B NM_007873 Doc2b B NM_145549 Efcab7 B NM_021791 Doc2g B NM_027031 Efcab9 B NM_001128308 Dock9 B NM_146015 Efemp1 B NM_053246 Dok4 B NM_028643 Efha1 B NM_029761 Dok5 B NM_172497 Efhb B NM_033613 Dom3z B NM_010108 Efna3 B NM_021720 Donson B NM_010110 Efnb1 B NM_144491 Dph1 B NM_010111 Efnb2 B NM_001047433 Dph3 B NM_007911 Efnb3 B NM_027193 Dph5 B NM_001159672 Eftud1 B NM_199021 Dpp10 B NM_053208 Egln2 B NM_001136060 Dpp6 B NM_018781 Egr3 B NM_031843 Dpp7 B NM_153068 Ehd2 B NM_028610 Dppa4 B NM_020578 Ehd3 B NM_019759 Dpt B NM_147151 Ehmt2 B NM_001146224 Dpy30 B NM_011508 Eif1 B NM_022722 Dpys B NM_010120 Eif1a B NM_001136086 Dpysl3 B NM_001005509 Eif2a B NM_011993 Dpysl4 B NM_010121 Eif2ak3 B NM_033606 Dqx1 B NM_026030 Eif2s2 B NM_026106 Dr1 B NM_028659 Eif3k B NM_010076 Drd1a B NM_144958 Eif4a1 B NM_010077 Drd2 B NM_010124 Eif4ebp2 B NM_013503 Drd5 B NM_181582 Eif5a B NM_010078 Drp2 B NM_010579 Eif6 B NM_013504 Dsc1 B NM_023502 Elf2 B NM_007882 Dsc3 B NM_019680 Elf4 B NM_031174 Dscam B NM_001145813 Elf5 B NM_030596 Dsg3 B NM_080288 Elmo1 B NM_023842 Dsp B NM_177769 Elmod1 B NM_010080 Dspp B NM_007925 Eln B NM_010087 Dtna B NM_130450 Elovl6 B NM_026981 Dtwd1 B NM_021448 Elp2 B NM_008052 Dtx1 B NM_133222 Eltd1 B NM_023742 Dtx2 B NM_016885 Emcn B NM_001013371 Dtx3l B NM_024474 Emid2 B

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NM_133918 Emilin1 B NM_028666 Fam110a B NM_146016 Eml6 B NM_198105 Fam120c B NM_010128 Emp1 B NM_030167 Fam122b B NM_001146346 Emp3 B NM_028671 Fam122c B NM_010132 Emx2 B NM_175184 Fam125b B NM_010134 En2 B NM_172513 Fam126b B NM_017468 Enam B NM_133778 Fam131a B NM_028013 Endod1 B NM_001113327 Fam131b B NM_027147 Enho B NM_025459 Fam134b B NM_023119 Eno1 B NM_026604 Fam135a B NM_013509 Eno2 B NM_025591 Fam136a B NM_001163035 Enoph1 B NM_001159743 Fam150b B NM_145951 Enox2 B NM_177894 Fam154b B NM_007934 Enpep B NM_173446 Fam155a B NM_008813 Enpp1 B NM_033146 Fam158a B NM_032003 Enpp5 B NM_172682 Fam160a1 B NM_001026212 Ensa B NM_199009 Fam160a2 B NM_009849 Entpd2 B NM_027342 Fam162a B NM_007647 Entpd5 B NM_175427 Fam163b B NM_172117 Entpd6 B NM_173181 Fam164a B NM_010136 Eomes B NM_029172 Fam164b B NM_183428 Epb4.1 B NM_177628 Fam167a B NM_013511 Epb4.1l2 B NM_182783 Fam167b B NM_013512 Epb4.1l4a B NM_001160235 Fam168b B NM_145506 Epb4.1l5 B NM_001146045 Fam169a B NM_007935 Epc1 B NM_172405 Fam175a B NM_172663 Epc2 B NM_027957 Fam178b B NM_010140 Epha3 B NM_177087 Fam179a B NM_007936 Epha4 B NM_173375 Fam180a B NM_010141 Epha7 B NM_021427 Fam181b B NM_007939 Epha8 B NM_001014995 Fam189b B NM_001159571 Ephb4 B NM_001013778 Fam18a B NM_007940 Ephx2 B NM_145382 Fam193b B NM_001001804 Ephx4 B NM_182808 Fam19a1 B NM_010147 Epn1 B NM_183224 Fam19a3 B NM_029735 Eprs B NM_177233 Fam19a4 B NM_021563 Erbb2ip B NM_153782 Fam20a B NM_010153 Erbb3 B NM_025377 Fam33a B NM_011729 Ercc5 B NM_001039485 Fam38b B NM_007950 Ereg B NM_153563 Fam40a B NM_007951 Erh B NM_175307 Fam46b B NM_027698 Eri2 B NM_001142952 Fam46c B NM_023913 Ern1 B NM_019995 Fam48a B NM_001014976 Espl1 B NM_175268 Fam53b B NM_207687 Espn B NM_175104 Fam53c B NM_007953 Esrra B NM_027930 Fam54a B NM_011934 Esrrb B NM_029759 Fam54b B NM_011843 Esyt1 B NM_172921 Fam55d B NM_177775 Esyt3 B NM_197989 Fam58b B NM_026695 Etfb B NM_001033445 Fam59a B NM_011809 Ets2 B NM_153539 Fam5c B NM_001163154 Etv1 B NM_019643 Fam60a B NM_007967 Evx2 B NM_133858 Fam63a B NM_007968 Ewsr1 B NM_144526 Fam64a B NM_027270 Exoc1 B NM_173770 Fam69c B NM_009148 Exoc4 B NM_001109759 Fam71a B NM_172456 Exog B NM_175382 Fam72a B NM_025644 Exosc1 B NM_001162375 Fam73a B NM_016699 Exosc10 B NM_001160261 Fam78b B NM_025513 Exosc3 B NM_201361 Fam82a1 B NM_175399 Exosc4 B NM_001045518 Fam83b B NM_138586 Exosc5 B NM_027788 Fam83c B NM_027148 Exosc8 B NM_145986 Fam83f B NM_007970 Ezh1 B NM_029007 Fam84a B NM_009510 Ezr B NM_001033244 Fancd2 B NM_021489 F12 B NM_025923 Fancl B NM_010170 F2rl2 B NM_007986 Fap B NM_007979 F9 B NM_025648 Farsa B NM_008375 Fabp6 B NM_007988 Fasn B NM_021272 Fabp7 B NM_027123 Fastkd3 B NM_021890 Fads3 B NM_001081286 Fat1 B NM_007983 Faf1 B NM_183221 Fat4 B NM_029629 Fahd2a B NM_001004147 Fbll1 B NM_176902 Fam100b B NM_007993 Fbn1 B

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NM_010181 Fbn2 B NM_146215 Ftsjd1 B NM_028149 Fbxl20 B NM_028058 Fundc1 B NM_175206 Fbxl22 B NM_001081454 Furin B NM_015821 Fbxl8 B NM_028428 Fut11 B NM_176848 Fbxo2 B NM_013524 Fut7 B NM_026346 Fbxo32 B NM_022004 Fxyd6 B NM_001161851 Fbxo44 B NM_022007 Fxyd7 B NM_173439 Fbxo45 B NM_148925 Fyco1 B NM_015791 Fbxo8 B NM_021458 Fzd3 B NM_134015 Fbxw11 B NM_001162494 Fzd6 B NM_013907 Fbxw4 B NM_008057 Fzd7 B NM_080428 Fbxw7 B NM_008058 Fzd8 B NM_026791 Fbxw9 B NM_008061 G6pc B NM_144960 Fcamr B NM_021331 G6pc2 B NM_010185 Fcer1g B NM_175935 G6pc3 B NM_013517 Fcer2a B NM_026693 Gabarapl2 B NM_172591 Fcho2 B NM_001081141 Gabbr2 B NM_001029984 Fcrlb B NM_207669 Gabpb1 B NM_001039824 Fdx1l B NM_029885 Gabpb2 B NM_198675 Fdxacb1 B NM_010250 Gabra1 B NM_001037997 Fert2 B NM_001099641 Gabra6 B NM_001083905 Fetub B NM_008070 Gabrb2 B NM_153111 Fev B NM_008071 Gabrb3 B NM_146187 Ffar2 B NM_020488 Gabrq B NM_010196 Fga B NM_008076 Gabrr2 B NM_181849 Fgb B NM_008078 Gad2 B NM_015759 Fgd3 B NM_008079 Galc B NM_172731 Fgd5 B NM_178389 Gale B NM_010198 Fgf11 B NM_016905 Galk1 B NM_207667 Fgf14 B NM_001081421 Galntl1 B NM_008003 Fgf15 B NM_175032 Galntl6 B NM_010204 Fgf6 B NM_008060 Ganab B NM_008009 Fgfbp1 B NM_008083 Gap43 B NM_010206 Fgfr1 B NM_178888 Garnl3 B NM_010207 Fgfr2 B NM_001113346 Gatad2a B NM_008011 Fgfr4 B NM_139304 Gatad2b B NM_133862 Fgg B NM_028022 Gatsl3 B NM_029347 Fggy B NM_008094 Gba B NM_001033301 Fhdc1 B NM_028803 Gbe1 B NM_010211 Fhl1 B NM_018734 Gbp3 B NM_010212 Fhl2 B NM_153564 Gbp5 B NM_010214 Fhl4 B NM_015739 Gbx1 B NM_021438 Fibp B NM_010262 Gbx2 B NM_012013 Figla B NM_008096 Gc B NM_173397 Fitm2 B NM_028407 Gcap14 B NM_001111066 Fkbp8 B NM_001161712 Gcat B NM_134080 Flnb B NM_028900 Gcc1 B NM_008027 Flot1 B NM_008104 Gcm2 B NM_201518 Flrt2 B NM_019580 Gde1 B NM_013520 Flt3l B NM_008109 Gdf5 B NM_018881 Fmo2 B NM_013526 Gdf6 B NM_172844 Fmo9 B NM_010275 Gdnf B NM_001038700 Fnbp1 B NM_025638 Gdpd1 B NM_173753 Fnip1 B NM_023608 Gdpd2 B NM_010234 Fos B NM_010276 Gem B NM_022378 Foxb1 B NM_177367 Gemin4 B NM_008242 Foxd1 B NM_172558 Gemin5 B NM_010425 Foxd3 B NM_177331 Gen1 B NM_010426 Foxf1a B NM_177266 Gfm2 B NM_010225 Foxf2 B NM_173048 Gga3 B NM_001160112 Foxg1 B NM_010281 Ggh B NM_007989 Foxh1 B NM_010283 Ggta1 B NM_023907 Foxi1 B NM_078478 Ghitm B NM_180974 Foxn2 B NM_031408 Gigyf1 B NM_183186 Foxn3 B NM_001110212 Gigyf2 B NM_212435 Foxp2 B NM_008376 Gimap1 B IgH NM_028767 Foxp4 B NM_175035 Gimap5 B IgH NM_172291 Foxred1 B NM_146167 Gimap7 B NM_172862 Frem2 B NM_024240 Gins4 B NM_177750 Frmpd3 B NM_019834 Git2 B NM_172904 Fsd2 B NM_010289 Gja10 B NM_008045 Fshb B NM_001001496 Gja6 B NM_027759 Fsip1 B NM_008124 Gjb1 B NM_178673 Fstl5 B NM_008125 Gjb2 B

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NM_008127 Gjb4 B NM_175380 Gpd1l B NM_025467 Gkn2 B NM_175644 Gphb5 B NM_026860 Gkn3 B NM_008155 Gpi1 B NM_013463 Gla B NM_008156 Gpld1 B NM_027450 Glipr2 B NM_153581 Gpm6a B NM_175459 Glis3 B NM_133884 Gpn2 B NM_020492 Glra1 B NM_030067 Gpr115 B NM_010297 Glra4 B NM_001081178 Gpr116 B NM_008132 Glrp1 B NM_177469 Gpr123 B NM_028419 Glrx5 B NM_133911 Gpr125 B NM_001081081 Gls B NM_177346 Gpr149 B NM_146211 Glt25d1 B NM_001162955 Gpr15 B IgH NM_177130 Glt28d2 B NM_175495 Gpr150 B NM_146020 Gltpd2 B NM_181543 Gpr151 B NM_001162944 Gm10318 B NM_206973 Gpr152 B NM_001080776 Gm1123 B NM_001004761 Gpr158 B NM_001045543 Gm11435 B NM_173398 Gpr171 B NM_001127354 Gm11938 B NM_201367 Gpr176 B NM_001033302 Gm129 B NM_182806 Gpr18 B NM_001085542 Gm13124 B NM_007412 Gpr182 B NM_001110517 Gm14446 B NM_008158 Gpr27 B NM_001081476 Gm14725 B NM_029771 Gpr30 B NM_001100608 Gm15450 B NM_001013832 Gpr31c B NM_001033442 Gm1604b B NM_009962 Gpr44 B NM_148934 Gm16517 B NM_010340 Gpr50 B NM_001033333 Gm239 B NM_001159652 Gpr62 B NM_011509 Gm3258 B NM_030733 Gpr63 B NM_001123372 Gm3435 B NM_175669 Gpr82 B NM_001038995 Gm4787 B NM_030720 Gpr84 B NM_001029977 Gm4788 B NM_145066 Gpr85 B NM_177808 Gm5082 B NM_026229 Gpr89 B NM_177813 Gm5087 B NM_054053 Gpr98 B NM_203660 Gm5136 B NM_001163016 Gprasp2 B NM_001111145 Gm514 B NM_012014 Gprin1 B NM_198657 Gm5148 B NM_183209 Gprin2 B NM_001003664 Gm5409 B NM_134116 Gpsm3 B NM_001025388 Gm5506 B NM_024198 Gpx7 B NM_001004182 Gm5567 B NM_172768 Gramd1b B NM_001033297 Gm561 B NM_001033498 Gramd2 B NM_001085505 Gm572 B NM_010815 Grap2 B NM_001038997 Gm5771 B NM_001083628 Greb1l B NM_001034902 Gm5878 B NM_145890 Grhl1 B NM_001013761 Gm606 B NM_080289 Grhpr B IgH and Myc NM_001033362 Gm614 B NM_008165 Gria1 B NM_001081564 Gm6592 B NM_008166 Grid1 B NM_001033411 Gm826 B NM_133355 Grid2ip B NM_001033280 Gm94 B NM_175481 Grik4 B NM_001013771 Gm973 B NM_008169 Grin1 B NM_001039192 Gmfg B NM_178602 Grinl1a B NM_133708 Gmppa B NM_001159507 Grip2 B NM_177910 Gmppb B NM_011938 Grk6 B NM_010303 Gna13 B NM_172739 Grlf1 B NM_008138 Gnai2 B NM_181850 Grm3 B NM_010306 Gnai3 B NM_177328 Grm7 B NM_010307 Gnal B NM_001098476 Grsf1 B NM_201616 Gnas B NM_001018019 Grxcr1 B NM_008140 Gnat1 B NM_010351 Gsc B NM_008141 Gnat2 B NM_026960 Gsdmd B NM_001160016 Gnb1 B NM_001080553 Gsg1 B NM_013530 Gnb3 B NM_010344 Gsr B NM_025277 Gng10 B NM_026231 Gstcd B NM_145552 Gnl2 B NM_026764 Gstm4 B NM_010321 Gnmt B NM_010360 Gstm5 B NM_172529 Gnptg B NM_029472 Gstt4 B NM_008145 Gnrh1 B NM_133256 Gsx2 B NM_027694 Golga7b B NM_172662 Gtdc1 B NM_019650 Gosr2 B NM_008186 Gtf2h1 B NM_010325 Got2 B NM_172977 Gtf3c4 B NM_008149 Gpam B NM_008187 Gtl3 B NM_001128597 Gpank1 B NM_013818 Gtpbp1 B NM_001081089 Gpat2 B NM_027000 Gtpbp4 B NM_008150 Gpc4 B NM_025332 Gtpbp8 B NM_001079844 Gpc6 B NM_010368 Gusb B NM_001042672 Gpcpd1 B NM_198612 Gxylt2 B

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NM_172670 Gyltl1b B NM_010441 Hmga2 B NM_030678 Gys1 B NM_010439 Hmgb1 B NM_010374 Gzmf B NM_008252 Hmgb2 B NM_008196 Gzmk B NM_173731 Hmgcll1 B NM_001159553 H13 B NM_026122 Hmgn3 B NM_008197 H1f0 B NM_178017 Hmgxb4 B NM_010378 H2-Aa B NM_027521 Hmha1 B NM_010387 H2-DMb1 B NM_001136066 Hmox2 B NM_010382 H2-Eb1 B NM_008261 Hnf4a B NM_010385 H2-Ke2 B NM_013920 Hnf4g B NM_010389 H2-Ob B NM_016806 Hnrnpa2b1 B NM_146101 Habp2 B NM_198090 Hnrnpa3 B NM_019986 Habp4 B NM_016884 Hnrnpc B NM_008212 Hadh B NM_019868 Hnrnph2 B NM_010401 Hal B NM_001079824 Hnrnph3 B NM_010403 Hao1 B NM_177301 Hnrnpl B NM_019545 Hao2 B NM_028871 Hnrnpr B NM_177900 Hapln4 B NM_144922 Hnrnpul1 B NM_025475 Haus2 B NM_016690 Hnrpdl B NM_153198 Hbp1 B NM_001159900 Hopx B NM_008222 Hccs B NM_010449 Hoxa1 B NM_008224 Hcfc1 B NM_001122950 Hoxa10 B NM_008225 Hcls1 B NM_008264 Hoxa13 B NM_008227 Hcn3 B NM_010452 Hoxa3 B NM_001081192 Hcn4 B NM_010454 Hoxa6 B NM_001163027 Hcrtr1 B NM_010456 Hoxa9 B NM_008229 Hdac2 B NM_134032 Hoxb2 B NM_001077696 Hdac5 B NM_010458 Hoxb3 B NM_019572 Hdac7 B NM_008268 Hoxb5 B NM_027382 Hdac8 B NM_008269 Hoxb6 B NM_008230 Hdc B NM_010460 Hoxb7 B NM_013886 Hdgfrp3 B NM_010462 Hoxc10 B NM_001080549 Hdx B NM_001024842 Hoxc11 B NM_172757 Heatr3 B NM_013553 Hoxc4 B NM_145432 Heatr6 B NM_008272 Hoxc9 B NM_175256 Heg1 B NM_008274 Hoxd12 B NM_001081107 Helq B NM_008276 Hoxd8 B NM_175189 Hepacam B NM_017370 Hp B NM_001159628 Heph B NM_010471 Hpca B NM_008236 Hes2 B NM_016677 Hpcal1 B NM_008237 Hes3 B NM_019424 Hps1 B NM_010421 Hexa B NM_001005247 Hps5 B NM_138753 Hexim1 B NM_017371 Hpx B NM_010423 Hey1 B NM_013751 Hrasls B NM_013904 Hey2 B NM_027511 Hrct1 B NM_010424 Hfe B NM_153087 Hrh4 B NM_013547 Hgd B NM_007545 Hrk B NM_029884 Hgsnat B NM_001081208 Hs3st5 B NM_008245 Hhex B NM_015819 Hs6st2 B NM_020259 Hhip B NM_015820 Hs6st3 B NM_146108 Hibch B NM_001044751 Hsd11b1 B NM_176958 Hif1an B NM_008289 Hsd11b2 B NM_016868 Hif3a B NM_053262 Hsd17b11 B NM_019814 Higd1a B NM_198030 Hsd17b13 B NM_025933 Higd2a B NM_010480 Hsp90aa1 B NM_018792 Hils1 B NM_008301 Hspa2 B NM_145070 Hip1r B NM_030704 Hspb8 B NM_010433 Hipk2 B NM_013559 Hsph1 B NM_001033315 Hipk4 B NM_001146052 Htatip2 B NM_020034 Hist1h1b B IgH NM_028242 Htatsf1 B NM_178189 Hist1h2ac B NM_008308 Htr1a B NM_023422 Hist1h2bc B NM_010482 Htr1b B NM_178197 Hist1h2bh B NM_013561 Htr3a B NM_178200 Hist1h2bm B NM_020274 Htr3b B NM_178207 Hist1h3i B NM_021358 Htr6 B NM_175655 Hist1h4f B NM_019564 Htra1 B NM_001146100 Hk1 B NM_019752 Htra2 B NM_013820 Hk2 B NM_153072 Hus1b B NM_001033245 Hk3 B NM_021523 Huwe1 B NM_145419 Hkdc1 B NM_029762 Hyls1 B NM_144959 Hltf B NM_001033780 I830077J02Rik B NM_001110251 Hmbs B NM_172015 Iars B NM_025812 Hmg20a B NM_008318 Ibsp B NM_001163166 Hmg20b B NM_001081282 Ibtk B

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NM_029573 Idh3a B NM_153134 Irgq B NM_130884 Idh3b B NM_010570 Irs1 B NM_008325 Idua B NM_010574 Irx2 B NM_133662 Ier3 B NM_008393 Irx3 B NM_178787 Iffo1 B NM_001126490 Ism1 B NM_008329 Ifi204 B NM_178629 Ispd B NM_023065 Ifi30 B NM_008395 Itch B NM_008331 Ifit1 B NM_133927 Itfg2 B NM_013562 Ifrd1 B NM_001033228 Itga1 B NM_025903 Ifrd2 B NM_008397 Itga6 B NM_026298 Ift172 B NM_008398 Itga7 B NM_008988 Igdcc3 B NM_001001309 Itga8 B NM_001122736 Igf2 B NM_001029872 Itgad B NM_009951 Igf2bp1 B NM_008403 Itgb1bp1 B NM_008342 Igfbp2 B NM_026348 Itgb3bp B NM_008343 Igfbp3 B NM_001145884 Itgb5 B NM_010517 Igfbp4 B NM_001159564 Itgb6 B NM_018741 Igfbpl1 B NM_013566 Itgb7 B NM_030691 Igsf6 B NM_008406 Itih1 B NM_001145800 Igsf9 B NM_008410 Itm2b B NM_011879 Ik B NM_022417 Itm2c B NM_001161421 Ikbkg B NM_181593 Itpkc B NM_011772 Ikzf4 B NM_010585 Itpr1 B NM_008348 Il10ra B NM_173441 Iws1 B NM_010549 Il11ra1 B NM_001018013 Izumo1 B NM_008351 Il12a B NM_010589 Jak3 B NM_008354 Il12rb2 B NM_023277 Jam3 B NM_145834 Il17c B NM_021878 Jarid2 B NM_010553 Il18rap B NM_173406 Jazf1 B NM_010555 Il1r2 B NM_001033430 Jhdm1d B NM_030688 Il1rapl2 B NM_028792 Josd1 B NM_001159562 Il1rn B NM_025368 Josd2 B NM_021380 Il20 B NM_021566 Jph2 B NM_001033543 Il20rb B NM_010591 Jun B NM_178258 Il22ra2 B NM_001142724 Kbtbd12 B NM_008367 Il2ra B NM_026962 Kbtbd3 B NM_133775 Il33 B NM_010595 Kcna1 B NM_010558 Il5 B NM_008417 Kcna2 B NM_031168 Il6 B NM_008418 Kcna3 B NM_010560 Il6st B NM_008424 Kcne1 B NM_008372 Il7r B NM_021487 Kcne1l B NM_026374 Ilf2 B NM_021342 Kcne4 B NM_001161724 Ilk B NM_025734 Kcng4 B NM_011830 Impdh2 B NM_010600 Kcnh1 B NM_146100 Ina B NM_001037712 Kcnh6 B NM_198411 Inf2 B IgH NM_133207 Kcnh7 B NM_011919 Ing1 B NM_030265 Kcnip4 B NM_133345 Ing4 B NM_019659 Kcnj1 B NM_010564 Inha B NM_010603 Kcnj12 B NM_008380 Inhba B NM_145963 Kcnj14 B NM_009349 Inmt B NM_008427 Kcnj4 B NM_023547 Ino80b B NM_008429 Kcnj9 B NM_008384 Inpp1 B NM_029911 Kcnk10 B NM_008916 Inpp5k B NM_010609 Kcnk7 B NM_010567 Inppl1 B NM_010610 Kcnma1 B NM_178082 Insig2 B NM_080466 Kcnn3 B NM_013564 Insl3 B NM_001006675 Kcnq2 B NM_020287 Insm2 B NM_152923 Kcnq3 B NM_011832 Insrr B NM_206974 Kcnrg B NM_027927 Ints12 B NM_173417 Kcns3 B NM_145540 Ints3 B NM_183179 Kcnv2 B NM_010569 Invs B NM_134112 Kctd1 B NM_029665 Ipo11 B NM_183285 Kctd2 B NM_146152 Ipo13 B NM_025888 Kctd20 B NM_023579 Ipo5 B NM_027008 Kctd5 B NM_181517 Ipo7 B NM_175519 Kctd8 B NM_153774 Ipo9 B NM_133950 Kdelr1 B NM_030068 Iqch B NM_001161823 Kdm4a B NM_001134383 Iqsec1 B NM_152895 Kdm5b B NM_001114664 Iqsec2 B NM_013668 Kdm5c B NM_001033354 Iqsec3 B NM_008438 Kera B NM_008363 Irak1 B NM_010158 Khdrbs3 B NM_016851 Irf6 B NM_001081177 Kif13b B NM_008392 Irg1 B NM_010623 Kif17 B

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NM_139303 Kif18a B NM_008489 Lbp B NM_009004 Kif20a B NM_010692 Lbx2 B NM_024241 Kif24 B NM_008490 Lcat B NM_001097621 Kif26a B NM_026811 Lce1e B NM_175214 Kif27 B NM_001039594 Lce3a B NM_001145779 Kif2a B NM_025501 Lce3b B NM_028547 Kif2b B NM_033175 Lce3c B NM_008449 Kif5c B NM_001018079 Lce3f B NM_010626 Kif7 B NM_001162433 Lck B NM_001145832 Kifc3 B NM_172153 Lcorl B NM_026324 Kirrel3 B NM_027570 Ldhd B NM_013598 Kitl B NM_153069 Leap2 B NM_013823 Kl B NM_010701 Lect1 B NM_009769 Klf5 B NM_010702 Lect2 B NM_027117 Klhdc2 B IgH NM_010703 Lef1 B NM_145605 Klhdc4 B NM_027203 Leng1 B NM_001039061 Klhl15 B NM_175529 Leng9 B NM_001039482 Klhl20 B NM_008493 Lep B NM_029652 Klhl25 B NM_019783 Lepre1 B NM_172781 Klhl4 B NM_176830 Leprel4 B NM_019974 Klk11 B NM_173012 Letm2 B NM_019928 Klk4 B NM_025622 Lgals2 B NM_011177 Klk6 B NM_001159301 Lgals9 B NM_008940 Klk8 B NM_144945 Lgi2 B NM_028658 Klraq1 B NM_144556 Lgi4 B NM_010652 Klrc1 B NM_010195 Lgr5 B NM_010654 Klrd1 B NM_001039653 Lhx3 B NM_001083322 Klrk1 B NM_008499 Lhx5 B NM_177261 Kndc1 B NM_010713 Lhx8 B NM_001102411 Kng1 B NM_001042577 Lhx9 B NM_001102409 Kng2 B NM_013584 Lifr B NM_008465 Kpna1 B NM_001083188 Lig1 B NM_008468 Kpna6 B NM_010716 Lig3 B NM_032396 Kremen1 B NM_001113545 Lima1 B NM_010661 Krt12 B NM_013860 Limd1 B NM_016958 Krt14 B NM_001034030 Limk2 B NM_008470 Krt16 B NM_011699 Lin7c B NM_010664 Krt18 B NM_175516 Lingo2 B NM_172946 Krt222 B NM_010720 Lipg B NM_033373 Krt23 B NM_172837 Lipk B NM_133730 Krt25 B NM_025681 Lix1 B NM_001033397 Krt26 B NM_001163170 Lix1l B NM_010659 Krt31 B NM_025431 Llph B NM_027563 Krt34 B NM_027400 Lman1 B NM_213730 Krt39 B NM_199222 Lman1l B NM_001039666 Krt40 B NM_001013374 Lman2l B NM_212483 Krt42 B NM_029098 Lmbr1l B NM_213728 Krt72-ps B NM_001111102 Lmna B NM_001033177 Krt76 B NM_053098 Lmod2 B NM_016879 Krt85 B NM_001005511 Lmtk3 B NM_201255 Krt9 B NM_027133 Lnp B NM_010671 Krtap13 B NM_001029878 Lonrf2 B NM_001085526 Krtap1-3 B NM_010728 Lox B NM_013713 Krtap15 B NM_033325 Loxl2 B NM_130873 Krtap16-4 B NM_010336 Lpar1 B NM_028621 Krtap16-7 B NM_175271 Lpar4 B NM_130876 Krtap16-9 B NM_027599 Lpcat2b B NM_010673 Krtap6-2 B NM_001081298 Lphn2 B NM_027771 Krtap7-1 B NM_198702 Lphn3 B NM_010676 Krtap8-2 B NM_022882 Lpin2 B NM_027221 Krtcap3 B NM_134152 Lpxn B NM_001033131 Krtdap B NM_001081173 Lrch2 B NM_001081338 L3mbtl1 B NM_030562 Lrfn1 B NM_172787 L3mbtl3 B NM_175478 Lrfn3 B NM_010679 Lalba B NM_029796 Lrg1 B NM_010683 Lamc1 B NM_008377 Lrig1 B NM_008485 Lamc2 B NM_146245 Lrit1 B NM_031248 Lamtor2 B NM_008511 Lrmp B NM_024434 Lap3 B NM_026278 Lrp2bp B NM_001080948 Larp4 B NM_001145857 Lrp4 B NM_134137 Lars B NM_001111140 Lrrc10b B NM_029789 Lass2 B NM_145471 Lrrc14 B NM_020044 Lat2 B NM_028838 Lrrc2 B NM_001033534 Layn B NM_013588 Lrrc23 B

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NM_175124 Lrrc28 B NM_001083341 Mboat2 B NM_146052 Lrrc3b B NM_001114179 Mcart6 B NM_001033461 Lrrc43 B NM_001085373 Mcc B NM_001159610 Lrrc57 B NM_139295 Mcfd2 B NM_153568 Lrrc66 B NM_008566 Mcm5 B NM_177725 Lrrc8a B NM_008568 Mcm7 B NM_001122768 Lrrc8d B NM_025676 Mcm8 B NM_027742 Lrrfip2 B NM_016766 Mcrs1 B NM_146191 Lrrk1 B NM_026902 Mcts1 B NM_010732 Lrrn2 B NM_025543 Mcts2 B NM_010733 Lrrn3 B NM_001010833 Mdc1 B NM_001013019 Lrrn4cl B NM_001081160 Mdga1 B NM_178731 Lrrtm4 B NM_008618 Mdh1 B NM_172492 Lrtm2 B NM_001012336 Mdk B NM_026032 Lsm1 B NM_020048 Med20 B NM_172947 Lsm12 B NM_026119 Med4 B NM_001110101 Lsm2 B NM_001104530 Med7 B NM_025520 Lsm5 B NM_001161790 Mefv B NM_025349 Lsm7 B NM_172522 Megf11 B NM_019919 Ltbp1 B NM_008583 Men1 B NM_013589 Ltbp2 B NM_008586 Mep1b B NM_001113549 Ltbp4 B NM_053172 Mepe B NM_181470 Ltv1 B NM_023403 Mesdc2 B NM_026313 Luc7l3 B NM_008588 Mesp1 B NM_024452 Luzp1 B NM_029790 Mettl15 B NM_148939 Ly6g5b B NM_001029990 Mettl17 B NM_008534 Ly9 B NM_001033236 Mettl21d B NM_008535 Lyl1 B NM_001029890 Mex3a B NM_182785 Lypd4 B NM_029409 Mff B NM_008866 Lypla1 B NM_026660 Mfsd10 B NM_175364 Lyrm2 B NM_178620 Mfsd11 B NM_029327 Lyrm7 B NM_027122 Mfsd3 B NM_153121 Lysmd1 B NM_172883 Mfsd7a B NM_027083 Lyzl6 B NM_172499 Mfsd9 B NM_033322 Lztfl1 B NM_001110148 Mgat1 B NM_025808 Lztr1 B NM_173870 Mgat4a B NM_145503 Lzts2 B NM_172948 Mgat5b B NM_010749 M6pr B NM_174995 Mgst2 B NM_001163136 Macc1 B NM_019394 Mia1 B NM_145527 Madd B NM_138315 Mical1 B NM_010755 Maff B NM_177461 Micall1 B NM_010756 Mafg B NM_174850 Micall2 B NM_173783 Mageb18 B NM_010797 Mid1 B NM_008545 Mageb3 B NM_172593 Mier3 B NM_019791 Maged1 B NM_027162 Mif4gd B NM_030700 Maged2 B NM_025910 Mina B NM_053206 Magee2 B NM_145374 Mios B NM_008547 Mak B NM_027436 Mipep B NM_174857 Mamdc2 B NM_172578 Mis18bp1 B NM_175334 Maml1 B NM_001122667 Mkl2 B NM_001081354 Mamld1 B NM_175403 Mlec B NM_008549 Man2a1 B NM_175337 Mlh3 B NM_172903 Man2a2 B NM_029931 Mllt3 B NM_026160 Map1lc3b B NM_010806 Mllt4 B NM_008927 Map2k1 B NM_139311 Mllt6 B NM_008928 Map2k3 B NM_029956 Mmab B NM_011943 Map2k6 B NM_146234 Mmgt1 B NM_001042557 Map2k7 B NM_008607 Mmp13 B NM_016693 Map3k6 B NM_008609 Mmp15 B NM_009006 Map4k2 B NM_032006 Mmp1a B NM_201519 Map4k5 B NM_032007 Mmp1b B NM_011950 Mapk13 B NM_008610 Mmp2 B NM_172632 Mapk4 B NM_172797 Mmp28 B NM_011941 Mapkbp1 B NM_001033450 Mnda B NM_007896 Mapre1 B NM_010813 Mnt B NM_010838 Mapt B NM_019944 Mnx1 B NM_177597 March11 B NM_001163024 Mon2 B NM_001003913 Mars B NM_198162 Morc2a B NM_001003893 Masp2 B NM_019768 Morf4l2 B NM_145569 Mat2a B NM_139296 Moxd2 B NM_010768 Matk B NM_011900 Mpdu1 B NM_010770 Matn3 B NM_010821 Mpeg1 B NM_013592 Matn4 B NM_010822 Mpg B NM_175341 Mbnl2 B NM_001081323 Mphosph9 B

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NM_016695 Mpp2 B NM_023556 Mvk B NM_019579 Mpp5 B NM_001008542 Mxi1 B NM_019939 Mpp6 B NM_024263 Mxra8 B NM_033564 Mpv17l B NM_001093766 Myadm B NM_183170 Mpv17l2 B NM_008653 Mybpc3 B NM_001083897 Mpzl1 B NM_026831 Mybphl B NM_029844 Mrap B NM_207215 Mycbp2 B NM_008624 Mras B NM_010852 Myef2 B NM_203490 Mrgprd B NM_030679 Myh1 B NM_145379 Mrgprf B NM_001161775 Myh11 B NM_026423 Mri1 B NM_001081250 Myh13 B NM_025606 Mrpl16 B NM_001039545 Myh2 B NM_026310 Mrpl18 B NM_001099635 Myh3 B NM_025302 Mrpl2 B NM_010856 Myh6 B NM_026591 Mrpl24 B NM_080728 Myh7 B NM_053159 Mrpl3 B NM_001085378 Myh7b B NM_025796 Mrpl33 B NM_021285 Myl1 B NM_017404 Mrpl39 B NM_010858 Myl4 B NM_053164 Mrpl43 B NM_172259 Myl6b B NM_001081210 Mrpl44 B NM_008659 Myo1c B NM_029017 Mrpl47 B NM_181072 Myo1e B NM_025595 Mrpl51 B NM_148413 Myo3a B NM_025474 Mrps14 B NM_177376 Myo3b B NM_025878 Mrps18b B NM_008663 Myo7a B NM_026826 Mrps18c B NM_010865 Myoc B NM_026080 Mrps24 B NM_010866 Myod1 B NM_207207 Mrps26 B NM_001099634 Myof B NM_145573 Mrps35 B NM_031189 Myog B NM_029963 Mrps5 B NM_001085509 Myom3 B NM_025305 Mrps7 B NM_145579 Mypop B NM_023536 Mrto4 B NM_026370 Myst1 B NM_194464 Mrvi1 B NM_001093778 Myt1l B NM_013516 Ms4a2 B NM_001024917 N4bp2 B NM_133246 Ms4a3 B NM_145974 N4bp3 B NM_019544 Msgn1 B NM_053089 Naa15 B NM_031870 Msh4 B NM_001081430 Naa30 B NM_054043 Msi2 B NM_030153 Naa35 B NM_001100451 Msl2 B NM_001009546 Naaladl1 B NM_010833 Msn B NM_008668 Nab2 B NM_009074 Mst1r B NM_138671 Nadk B NM_010834 Mstn B NM_013796 Nagpa B NM_010835 Msx1 B NM_145829 Nags B NM_013601 Msx2 B NM_021524 Nampt B NM_013603 Mt3 B NM_008671 Nap1l2 B NM_011842 Mta2 B NM_138742 Nap1l3 B NM_008634 Mtap1b B NM_001142950 Nars B NM_008632 Mtap2 B NM_153591 Nars2 B NM_008633 Mtap4 B NM_029090 Nat15 B NM_177293 Mtap7d3 B NM_010874 Nat2 B NM_026002 Mtdh B IgH and Myc NM_175272 Nav2 B NM_178051 Mterfd2 B NM_001113204 Ncam1 B NM_008636 Mtf1 B NM_146171 Ncapd2 B NM_008638 Mthfd2 B NM_144818 Ncaph B NM_133767 Mtif2 B NM_010877 Ncf2 B NM_029581 Mtif3 B NM_001001884 Nckap5l B NM_001039658 Mtl5 B NM_022996 Ndfip1 B NM_019926 Mtm1 B NM_010811 Ndst2 B NM_172742 Mtmr10 B NM_031186 Ndst3 B NM_133215 Mtmr4 B NM_010885 Ndufa2 B NM_145712 Mtnr1b B NM_001098789 Ndufa4l2 B NM_175374 Mtrf1l B NM_025597 Ndufb3 B NM_172480 Mtrr B NM_025316 Ndufb5 B NM_001146180 Mtss1 B NM_025843 Ndufb7 B NM_198625 Mtss1l B NM_023172 Ndufb9 B NM_001005865 Mtus1 B NM_021546 Necab3 B NM_001162945 Mtx3 B NM_025383 Necap2 B NM_013605 Muc1 B NM_008682 Nedd1 B NM_010739 Muc13 B NM_010890 Nedd4 B NM_008648 Mup4 B NM_010904 Nefh B NM_008649 Mup5 B NM_010910 Nefl B NM_026509 Murc B NM_146208 Neil3 B NM_181390 Mustn1 B NM_080849 Nek8 B NM_139063 Muted B NM_001037906 Nell1 B NM_001159581 Mutyh B NM_001047159 Net1 B

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NM_144946 Neto1 B NM_147201 Nrbp1 B NM_010893 Neu1 B NM_146150 Nrd1 B NM_001160163 Neu2 B NM_173440 Nrip1 B NM_173772 Neu4 B NM_175024 Nrn1l B NM_001081656 Neurl1b B NM_001013372 Nrp B NM_001013414 Neurl4 B NM_009513 Nrsn1 B NM_010895 Neurod2 B NM_020252 Nrxn1 B NM_007501 Neurod4 B NM_021552 Nsa2 B NM_009717 Neurod6 B NM_010941 Nsdhl B NM_010896 Neurog1 B NM_010945 Nsmaf B NM_009719 Neurog3 B NM_026330 Nsmce1 B IgH NM_001160317 Nfasc B NM_001162855 Nsmce4a B NM_016791 Nfatc1 B NM_178925 Nsun3 B NM_010899 Nfatc2 B NM_028142 Nsun4 B NM_008686 Nfe2l1 B NM_145414 Nsun5 B NM_001122953 Nfia B NM_026004 Nt5c3 B NM_001113210 Nfib B NM_008742 Ntf3 B NM_019408 Nfkb2 B NM_172290 Ntm B NM_010908 Nfkbib B NM_008744 Ntn1 B NM_010909 Nfkbil1 B NM_021320 Ntn4 B NM_008692 Nfyc B NM_030699 Ntng1 B NM_001111314 Ngef B NM_008747 Ntsr2 B NM_013609 Ngf B NM_016736 Nub1 B NM_033217 Ngfr B NM_001031664 Nudt10 B NM_178877 Nhedc2 B NM_026497 Nudt12 B NM_178777 Nhlh2 B NM_033080 Nudt19 B NM_025811 Nhlrc2 B NM_025539 Nudt2 B NM_172501 Nhlrc3 B NM_172288 Nup133 B NM_001039038 Nhlrc4 B NM_175749 Nup153 B NM_173390 Nhsl1 B NM_027091 Nup35 B NM_030701 Niacr1 B NM_153092 Nupl2 B NM_022988 Nif3l1 B NM_030250 Nus1 B NM_008697 Nin B NM_026171 Nvl B NM_023647 Nipa2 B NM_008751 Nxph1 B NM_027707 Nipbl B NM_001161430 Nxt2 B NM_022656 Nisch B NM_010952 Oaz2-ps B NM_023526 Nkiras1 B NM_016901 Oaz3 B NM_028024 Nkiras2 B NM_175360 Obfc1 B NM_010919 Nkx2-2 B NM_178884 Obsl1 B NM_010921 Nkx3-1 B NM_177215 Ocrl B NM_144955 Nkx6-1 B NM_027128 Odam B NM_183248 Nkx6-2 B NM_198673 Odf3l1 B NM_138666 Nlgn1 B NM_011855 Odz1 B NM_172932 Nlgn3 B NM_011856 Odz2 B NM_008702 Nlk B NM_001145937 Odz3 B NM_008703 Nmbr B NM_001081079 Ogfrl1 B NM_008704 Nme1 B NM_139144 Ogt B NM_080637 Nme5 B NM_010959 Oit3 B NM_008707 Nmt1 B NM_019498 Olfm1 B NM_019515 Nmu B NM_001030294 Olfm4 B NM_153079 Nmur2 B NM_133859 Olfml3 B NM_008711 Nog B NM_206822 Olfr10 B NM_001039351 Nolc1 B NM_146573 Olfr1002 B NM_025403 Nop10 B NM_146589 Olfr1022 B NM_178605 Nop16 B NM_001011872 Olfr1034 B NM_008712 Nos1 B NM_207561 Olfr1040 B NM_008716 Notch3 B NM_146366 Olfr1093 B NM_001029877 Nova2 B NM_146843 Olfr1097 B NM_008719 Npas2 B NM_146542 Olfr11 B NM_018787 Npff B NM_146594 Olfr1100 B NM_008723 Npm3 B NM_146591 Olfr1101 B NM_033525 Npnt B NM_207154 Olfr1102 B NM_010933 Nppc B NM_146349 Olfr1128 B NM_018879 Nprl2 B NM_146351 Olfr1133 B NM_181569 Nprl3 B NM_147030 Olfr1134 B NM_175678 Npsr1 B NM_146917 Olfr1179 B NM_007430 Nr0b1 B NM_146918 Olfr1180 B NM_011584 Nr1d2 B NM_146530 Olfr1186 B NM_201622 Nr1h5 B NM_146895 Olfr1201 B NM_183261 Nr2f2 B NM_001001810 Olfr1206 B NM_008173 Nr3c1 B NM_146778 Olfr1208 B NM_015743 Nr4a3 B NM_001011804 Olfr1211 B NM_139051 Nr5a1 B NM_207140 Olfr1212 B NM_030676 Nr5a2 B NM_146897 Olfr1214 B

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NM_146459 Olfr1215 B NM_146725 Olfr516 B NM_001011761 Olfr1229 B NM_001011846 Olfr517 B NM_146973 Olfr1234 B NM_146306 Olfr518 B NM_146808 Olfr1240 B NM_207160 Olfr519 B NM_146455 Olfr1241 B NM_147104 Olfr550 B NM_146791 Olfr1248 B NM_147088 Olfr569 B NM_001011796 Olfr1249 B NM_147110 Olfr570 B NM_146965 Olfr1250 B NM_147114 Olfr575 B NM_207568 Olfr1252 B NM_001001805 Olfr576 B NM_146476 Olfr1254 B NM_147087 Olfr585 B NM_146983 Olfr1256 B NM_207556 Olfr592 B NM_146982 Olfr1257 B NM_147055 Olfr649 B NM_146978 Olfr1258 B NM_147075 Olfr656 B NM_146981 Olfr1260 B NM_001011755 Olfr671 B NM_021368 Olfr1264 B NM_001011848 Olfr675 B NM_146652 Olfr13 B NM_147095 Olfr676 B NM_146401 Olfr1305 B NM_146758 Olfr678 B NM_146447 Olfr1309 B NM_207249 Olfr684 B NM_146292 Olfr1324 B NM_147061 Olfr691 B NM_001011820 Olfr1359 B NM_146453 Olfr693 B NM_146543 Olfr1360 B NM_028910 Olfr701 B NM_146540 Olfr1364 B NM_147032 Olfr705 B NM_146533 Olfr1367 B NM_001005570 Olfr707 B NM_207573 Olfr1380 B NM_147034 Olfr713 B NM_001011790 Olfr1382 B NM_054090 Olfr73 B NM_146472 Olfr1384 B NM_146363 Olfr731 B NM_001011805 Olfr1385 B NM_146663 Olfr733 B NM_001011741 Olfr1386 B NM_001011738 Olfr744 B NM_146473 Olfr1387 B NM_146298 Olfr746 B NM_146467 Olfr1388 B NM_207559 Olfr776 B NM_147065 Olfr1390 B NM_130866 Olfr78 B NM_146468 Olfr1391 B NM_146933 Olfr790 B NM_146471 Olfr1393 B NM_146930 Olfr791 B NM_146337 Olfr1396 B NM_146673 Olfr823 B NM_146680 Olfr1423 B NM_146674 Olfr824 B NM_146681 Olfr1424 B NM_146300 Olfr827 B NM_001011853 Olfr1425 B NM_146868 Olfr894 B NM_146806 Olfr143 B NM_146875 Olfr895 B NM_146414 Olfr1431 B NM_146871 Olfr898 B NM_146747 Olfr146 B NM_146874 Olfr900 B NM_008762 Olfr15 B NM_146872 Olfr908 B NM_207664 Olfr151 B NM_207560 Olfr924 B NM_001012269 Olfr1513 B NM_146815 Olfr926 B NM_019473 Olfr155 B NM_146441 Olfr933 B NM_146993 Olfr176 B NM_146326 Olfr943 B NM_146996 Olfr177 B NM_146828 Olfr975 B NM_146997 Olfr178 B NM_147108 Olfr979 B NM_001011662 Olfr180 B NM_147106 Olfr980 B NM_146999 Olfr181 B NM_146615 Olfr986 B NM_146322 Olfr187 B NM_001011534 Olfr988 B NM_146923 Olfr20 B NM_146865 Olfr992 B NM_001011789 Olfr222 B NM_138648 Olr1 B NM_146714 Olfr248 B NM_012050 Omd B NM_207553 Olfr251 B NM_008262 Onecut1 B NM_146920 Olfr267 B NM_194268 Onecut2 B NM_146824 Olfr273 B NM_207525 Opa3 B NM_146858 Olfr275 B NM_010098 Opn3 B NM_001011779 Olfr286 B NM_181753 Opn5 B NM_146625 Olfr355 B NM_198424 Orai3 B NM_146662 Olfr365 B NM_001033174 Osbp B NM_146986 Olfr38 B NM_024289 Osbpl5 B NM_001011851 Olfr412 B NM_172701 Oscp1 B NM_146761 Olfr414 B NM_133676 Osgep B NM_146305 Olfr420 B NM_028091 Osgepl1 B NM_146369 Olfr434 B NM_011019 Osmr B NM_146653 Olfr435 B NM_054049 Osr2 B NM_146987 Olfr457 B NM_025509 Ostc B NM_146382 Olfr461 B NM_008769 Otc B NM_146426 Olfr469 B NM_001018031 Otol1 B NM_146498 Olfr490 B NM_020595 Otor B NM_146737 Olfr494 B NM_011021 Otp B NM_146307 Olfr498 B NM_138604 Otud5 B NM_146311 Olfr510 B NM_001163191 Otud6a B NM_146726 Olfr514 B NM_144841 Otx2 B

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NM_027136 Ovca2 B NM_027654 Pcgf6 B NM_172908 Ovch2 B NM_018814 Pcnx B NM_007696 Ovgp1 B NM_175561 Pcnxl2 B NM_026936 Oxa1l B NM_008791 Pcp4 B NM_181859 Oxct2b B NM_013628 Pcsk1 B NM_145460 Oxnad1 B NM_013892 Pcsk1n B NM_001130166 Oxr1 B NM_008792 Pcsk2 B NM_011026 P2rx4 B NM_008794 Pcsk7 B NM_008772 P2ry1 B NM_008796 Pctp B NM_027571 P2ry12 B NM_001162946 Pcx B NM_183168 P2ry6 B NM_177546 Pcyt1b B NM_011031 P4ha2 B NM_001033313 Pdap1 B NM_011119 Pa2g4 B NM_011053 Pdcd11 B NM_008774 Pabpc1 B NM_011052 Pdcd6ip B NM_011861 Pacsin1 B NM_026176 Pdcl B NM_008775 Pafah1b2 B NM_001009979 Pde1a B NM_008778 Pak3 B NM_001008548 Pde2a B NM_001081390 Palld B NM_177145 Pde4dip B NM_001161747 Palm B NM_146086 Pde6a B NM_028877 Palm3 B NM_023898 Pde6h B NM_023245 Palmd B NM_008802 Pde7a B NM_133992 Pan2 B NM_013875 Pde7b B NM_001114339 Pank1 B NM_027924 Pdgfd B NM_153501 Pank2 B NM_011058 Pdgfra B NM_172990 Pank4 B NM_024221 Pdhb B NM_019482 Panx1 B NM_146156 Pdik1l B NM_198600 Papd7 B NM_016861 Pdlim1 B NM_019943 Papolb B NM_019417 Pdlim4 B NM_172555 Papolg B NM_022554 Pdlim5 B NM_023824 Paqr4 B NM_178939 Pdrg1 B NM_028748 Paqr5 B NM_172134 Pdxk B NM_001081050 Pard3b B NM_133226 Pdzd3 B NM_007415 Parp1 B NM_011063 Pea15a B NM_181402 Parp11 B NM_023523 Pecr B NM_177460 Parp16 B NM_023324 Peli1 B NM_030253 Parp9 B NM_172835 Peli3 B NM_026251 Patl2 B NM_029231 Pelp1 B NM_008780 Pax1 B NM_153796 Peo1 B NM_011037 Pax2 B NM_011066 Per2 B NM_013627 Pax6 B NM_008821 Pet2 B NM_011040 Pax8 B NM_145122 Pex16 B NM_026085 Pbld2 B NM_019961 Pex3 B NM_011865 Pcbp1 B NM_008822 Pex7 B NM_021568 Pcbp3 B NM_019932 Pf4 B NM_029357 Pcdh1 B NM_008824 Pfkfb1 B NM_001013753 Pcdh17 B NM_001162415 Pfkfb2 B NM_178685 Pcdh20 B NM_011072 Pfn1 B NM_001122758 Pcdh7 B NM_019540 Pfpl B NM_001081377 Pcdh9 B NM_145583 Pgap2 B NM_198117 Pcdha2 B NM_001033537 Pgap3 B NM_138662 Pcdha3 B NM_172627 Pggt1b B NM_201243 Pcdha8 B NM_009402 Pglyrp1 B NM_001003671 Pcdhac1 B NM_025700 Pgm1 B NM_001003672 Pcdhac2 B NM_028132 Pgm2 B NM_053135 Pcdhb10 B NM_027629 Pgm2l1 B NM_053138 Pcdhb13 B NM_008829 Pgr B NM_053139 Pcdhb14 B NM_198419 Phactr1 B NM_053140 Pcdhb15 B NM_001007154 Phactr3 B NM_053141 Pcdhb16 B NM_008831 Phb B NM_053142 Pcdhb17 B NM_018774 Phc2 B NM_053144 Pcdhb19 B NM_011077 Phex B NM_053147 Pcdhb22 B NM_024250 Phf10 B NM_053128 Pcdhb3 B NM_172705 Phf13 B NM_053130 Pcdhb5 B NM_199299 Phf15 B NM_053131 Pcdhb6 B NM_001081409 Phf20l1 B NM_033586 Pcdhga3 B NM_030064 Phf23 B NM_033587 Pcdhga4 B NM_027949 Phf7 B NM_033588 Pcdhga5 B NM_001145644 Phgr1 B NM_033592 Pcdhga9 B NM_008832 Phka1 B NM_033576 Pcdhgb4 B NM_172783 Phka2 B NM_033579 Pcdhgb7 B NM_009344 Phlda1 B NM_033580 Pcdhgb8 B NM_013750 Phlda3 B NM_033581 Pcdhgc3 B NM_008887 Phox2a B NM_009545 Pcgf2 B NM_008888 Phox2b B

32

NM_172992 Phtf2 B NM_026376 Plxnd1 B NM_172267 Phyhd1 B NM_021882 Pmel B NM_145981 Phyhip B NM_008885 Pmp22 B NM_001162846 Phyhipl B NM_008886 Pms2 B NM_053191 Pi15 B NM_001039509 Pnkd B NM_023734 Pi16 B NM_021549 Pnkp B NM_019663 Pias1 B NM_001034866 Pnldc1 B NM_029320 Pibf1 B NM_008890 Pnmt B NM_011081 Piga B NM_008891 Pnn B NM_018889 Pigb B NM_025443 Pno1 B NM_001039045 Pigc B NM_001122818 Pnpla6 B NM_001039536 Pigl B NM_026164 Pnpla8 B NM_026234 Pigm B NM_026383 Pnrc2 B NM_011822 Pigq B NM_027740 Poc1b B NM_201406 Pigs B NM_026173 Poc5 B NM_027388 Pigw B NM_172683 Pogz B NM_181414 Pik3c3 B NM_008893 Pola2 B NM_008839 Pik3ca B NM_026389 Poldip2 B NM_001024955 Pik3r1 B NM_021498 Pole3 B NM_008841 Pik3r2 B NM_012048 Polk B NM_181585 Pik3r3 B NM_009088 Polr1a B NM_153510 Pilra B NM_009085 Polr1c B NM_138606 Pim2 B NM_009089 Polr2a B NM_028228 Pinx1 B NM_009090 Polr2c B NM_008952 Pipox B NM_026329 Polr2g B NM_008850 Pitpna B NM_145632 Polr2h B NM_011256 Pitpnm2 B NM_028925 Polr3c B NM_011098 Pitx2 B NM_027241 Polr3gl B NM_008852 Pitx3 B NM_030229 Polr3h B NM_177905 Piwil4 B NM_026398 Pop5 B NM_008853 Pja1 B NM_022318 Popdc2 B NM_008861 Pkd2 B NM_145908 Porcn B NM_001163004 Pkd2l2 B NM_008849 Pou1f1 B NM_011105 Pkdrej B NM_011137 Pou2f1 B NM_138674 Pkhd1l1 B NM_011138 Pou2f2 B NM_008862 Pkia B NM_011141 Pou3f1 B NM_001039391 Pkig B NM_138944 Pou4f2 B NM_011099 Pkm2 B NM_175006 Pou6f2 B NM_178654 Pkn2 B NM_080555 Ppap2b B NM_016670 Pknox1 B NM_028000 Ppapdc1b B NM_148950 Pknox2 B NM_011145 Ppard B NM_019645 Pkp1 B NM_011146 Pparg B NM_023196 Pla2g12a B NM_176831 Ppcdc B NM_133792 Pla2g15 B NM_026494 Ppcs B NM_001024145 Pla2g4f B NM_011148 Ppef2 B NM_008867 Pla2r1 B NM_177373 Ppfia2 B NM_139198 Plac8 B NM_029741 Ppfia3 B NM_008872 Plat B NM_026352 Ppid B NM_008873 Plau B NM_019489 Ppie B NM_011113 Plaur B NM_134084 Ppif B NM_172147 Plb1 B NM_028430 Ppil6 B NM_008874 Plcb3 B NM_178795 Ppip5k1 B NM_013829 Plcb4 B NM_001159496 Ppm1b B NM_001081456 Plcd4 B NM_178726 Ppm1l B NM_019588 Plce1 B NM_026447 Ppm1m B NM_013880 Plcl2 B NM_031868 Ppp1ca B NM_177355 Plcxd3 B NM_172707 Ppp1cb B NM_178911 Pld4 B NM_175934 Ppp1r10 B NM_176916 Pld5 B NM_027892 Ppp1r12a B NM_201394 Plec B NM_008654 Ppp1r15a B NM_019549 Plek B NM_133819 Ppp1r15b B NM_031257 Plekha2 B NM_033371 Ppp1r16a B NM_148927 Plekha4 B NM_021391 Ppp1r1a B NM_001001335 Plekha8 B NM_172420 Ppp1r1c B NM_001083912 Plekhg2 B NM_080464 Ppp1r3a B NM_183034 Plekhm1 B NM_016854 Ppp1r3c B NM_175640 Plin1 B NM_138605 Ppp1r3f B NM_025836 Plin3 B NM_181595 Ppp1r9a B NM_001033298 Plk1s1 B NM_172261 Ppp1r9b B NM_001142916 Plod2 B NM_021529 Ppp2r3c B NM_011123 Plp1 B NM_198168 Ppp2r5b B NM_019755 Plp2 B NM_001081458 Ppp2r5c B NM_008883 Plxna3 B NM_009358 Ppp2r5d B NM_138749 Plxnb2 B NM_012024 Ppp2r5e B

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NM_008913 Ppp3ca B NM_011185 Psmb1 B NM_024459 Ppp3r1 B NM_013640 Psmb10 B NM_019674 Ppp4c B NM_175204 Psmb11 B NM_011155 Ppp5c B NM_008945 Psmb4 B NM_008918 Ppy B NM_025959 Psmc6 B NM_008919 Ppyr1 B NM_021526 Psmd14 B NM_025861 Pqlc1 B NM_026545 Psmd8 B NM_138602 Praf2 B NM_011189 Psme1 B NM_001123362 Prdm12 B NM_011190 Psme2 B NM_144789 Prdm15 B NM_134013 Psme4 B NM_181650 Prdm4 B NM_025682 Pspc1 B NM_011563 Prdx2 B NM_001081211 Ptafr B NM_016764 Prdx4 B NM_019550 Ptbp2 B NM_007453 Prdx6 B NM_027275 Ptcd3 B NM_025596 Prelid1 B NM_008957 Ptch1 B NM_054077 Prelp B NM_008958 Ptch2 B NM_011156 Prep B NM_001083342 Ptchd2 B NM_145984 Prepl B NM_018809 Ptf1a B NM_177782 Prex1 B NM_008964 Ptger2 B NM_016914 Prg3 B NM_011197 Ptgfrn B NM_001110146 Prg4 B NM_008969 Ptgs1 B NM_001033217 Prickle1 B NM_020623 Pth B NM_001134460 Prickle2 B NM_001083936 Pth1r B NM_175097 Prickle3 B NM_001162366 Ptk2b B NM_031869 Prkab1 B NM_008972 Ptma B NM_016781 Prkag1 B NM_008973 Ptn B NM_011103 Prkcd B NM_001012396 Ptpla B NM_001013833 Prkg1 B NM_011202 Ptpn11 B NM_008926 Prkg2 B NM_008976 Ptpn14 B NM_028410 Prkrir B NM_011877 Ptpn21 B NM_001101647 Prlh B NM_001081043 Ptpn23 B NM_011169 Prlr B NM_177081 Ptpn7 B NM_019830 Prmt1 B NM_011210 Ptprc B NM_001081240 Prmt10 B NM_016933 Ptprcap B NM_201371 Prmt8 B NM_011211 Ptprd B NM_011170 Prnp B NM_011212 Ptpre B NM_001045516 Proca1 B NM_011213 Ptprf B NM_011171 Procr B NM_008981 Ptprg B NM_144944 Prokr2 B NM_008982 Ptprj B NM_008644 Prol1 B NM_008985 Ptprn B NM_011173 Pros1 B NM_001081432 Ptprq B NM_197945 Prosapip1 B NM_011217 Ptprr B NM_026045 Prpf18 B NM_007955 Ptprv B NM_134129 Prpf19 B NM_001081306 Ptprz1 B NM_025845 Prpf38b B NM_178595 Ptrh1 B NM_018785 Prpf40a B NM_175004 Ptrh2 B NM_021463 Prps1 B NM_011220 Pts B NM_026662 Prps2 B NM_008987 Ptx3 B NM_144806 Prpsap2 B NM_023292 Pus3 B NM_175022 Prr12 B NM_021496 Pvrl3 B NM_025385 Prr13 B NM_029546 Pwp2 B NM_146026 Prr15l B NM_144795 Pycr1 B NM_001136270 Prr24 B NM_153781 Pygb B NM_175424 Prr9 B NM_026869 Pygo2 B NM_020027 Prrc2a B NM_029011 Pyroxd2 B NM_001081290 Prrc2c B NM_007376 Pzp B NM_178695 Prrg4 B NM_026111 Qpctl B NM_030890 Prrt1 B NM_198192 Qrfpr B NM_001102563 Prrt2 B NM_001081054 Qrsl1 B NM_001001796 Prrxl1 B NM_017382 Rab11a B NM_008939 Prss12 B NM_153140 Rab11fip3 B NM_019429 Prss16 B NM_024448 Rab12 B NM_026317 Prss37 B NM_026677 Rab13 B NM_153172 Prss45 B NM_009000 Rab24 B NM_028525 Prss52 B NM_023635 Rab27a B NM_001042710 Prss57 B NM_001082553 Rab27b B NM_175020 Prss58 B NM_026405 Rab32 B NM_181348 Prune2 B NM_001159482 Rab34 B NM_177420 Psat1 B NM_144538 Rab3il1 B NM_028627 Psd B NM_029391 Rab4b B NM_177698 Psd3 B NM_024287 Rab6 B NM_008943 Psen1 B NM_009005 Rab7 B NM_173432 Pskh1 B NM_173413 Rab8b B NM_011969 Psma7 B NM_145522 Rabepk B

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NM_011231 Rabggtb B NM_001040434 Rgag1 B NM_145510 Rabif B NM_183318 Rgag4 B NM_001044371 Rad17 B NM_177740 Rgma B NM_021385 Rad18 B NM_178615 Rgmb B NM_009010 Rad23a B NM_026418 Rgs10 B NM_011234 Rad51 B NM_001161822 Rgs17 B NM_011237 Rad9 B NM_022881 Rgs18 B NM_009019 Rag1 B NM_026446 Rgs19 B NM_009020 Rag2 B NM_009062 Rgs4 B NM_022327 Ralb B NM_011880 Rgs7 B NM_009067 Ralbp1 B NM_029879 Rgs7bp B NM_001159968 Ralgps2 B NM_029777 Rhbdd1 B NM_177721 Ranbp6 B NM_177370 Rhbdd3 B NM_019930 Ranbp9 B NM_010117 Rhbdf1 B NM_021329 Rangrf B NM_144816 Rhbdl1 B NM_145541 Rap1a B NM_139228 Rhbdl3 B NM_024457 Rap1b B NM_021375 Rhbg B NM_028712 Rap2b B NM_053075 Rheb B NM_172413 Rap2c B NM_007483 Rhob B NM_001099624 Rapgef2 B NM_007484 Rhoc B NM_175258 Rapgef6 B NM_175092 Rhof B NM_001080925 Rapgefl1 B NM_019566 Rhog B NM_001045513 Raph1 B NM_001013441 Ric8b B NM_009024 Rara B NM_053271 Rims2 B NM_011243 Rarb B NM_182929 Rims3 B NM_001042727 Rarg B NM_009066 Ring1 B NM_027852 Rarres2 B NM_009068 Ripk1 B NM_029182 Rasd2 B NM_023663 Ripk4 B NM_001017427 Rasef B NM_173184 Rln3 B NM_181318 Rasgef1b B NM_001011877 Rnase11 B NM_019713 Rassf1 B NM_001011687 Rnase13 B NM_138956 Rassf3 B NM_021472 Rnase4 B NM_018750 Rassf5 B NM_172612 Rnd1 B NM_146240 Rassf9 B NM_028810 Rnd3 B NM_027911 Raver1 B NM_026406 Rnf115 B NM_175023 Rbbp6 B NM_198251 Rnf133 B NM_145627 Rbm10 B NM_019706 Rnf138 B NM_028226 Rbm12b B NM_020012 Rnf14 B NM_028234 Rbm33 B NM_001081977 Rnf144a B NM_133242 Rbm39 B NM_146042 Rnf144b B NM_153586 Rbm41 B NM_028862 Rnf145 B NM_030243 Rbm43 B NM_001110196 Rnf146 B NM_153405 Rbm45 B NM_177378 Rnf150 B NM_025717 Rbm4b B NM_001160368 Rnf152 B NM_144948 Rbm7 B NM_027355 Rnf168 B NM_001141931 Rbms1 B NM_153504 Rnf183 B NM_178660 Rbms3 B NM_011277 Rnf2 B NM_011252 Rbmx B NM_178709 Rnf214 B NM_009034 Rbp2 B NM_025739 Rnf220 B NM_001042674 Rbpms B NM_194346 Rnf31 B NM_001024952 Rc3h1 B NM_021470 Rnf32 B NM_019466 Rcan1 B NM_001038993 Rnf38 B NM_030598 Rcan2 B NM_011279 Rnf7 B NM_054048 Rcor2 B NM_172998 Rnft2 B NM_001038846 Rcsd1 B NM_026440 Rnmt B NM_133832 Rdh10 B NM_181405 Rnpepl1 B NM_021557 Rdh11 B NM_001080127 Rnps1 B NM_023697 Rdh14 B NM_019413 Robo1 B NM_001104617 Rdx B NM_009071 Rock1 B NM_058214 Recql4 B NM_178164 Rod1 B NM_011259 Reg3a B NM_013845 Ror1 B NM_001161741 Reg3d B NM_013646 Rora B NM_009046 Relb B NM_001043354 Rorb B NM_080726 Rem2 B NM_011283 Rp1 B NM_025620 Rep15 B NM_026632 Rpa3 B NM_001079901 Repin1 B NM_025683 Rpe B NM_019570 Rev1 B NM_029548 Rph3al B NM_178916 Rfesd B NM_011287 Rpl10a B NM_026097 Rffl B NM_025974 Rpl14 B NM_011931 Rfwd2 B NM_025586 Rpl15 B NM_001024918 Rfx4 B NM_207523 Rpl23a B NM_177306 Rfx6 B NM_011975 Rpl27a B NM_133231 Rfxap B NM_053257 Rpl31 B NM_175389 Rg9mtd2 B NM_001005859 Rpl34 B

35

NM_025592 Rpl35 B NM_001077499 Scn8a B NM_026069 Rpl37 B NM_027013 Scnm1 B NM_009084 Rpl37a B NM_001039137 Scoc B NM_025425 Rpl3l B NM_020052 Scube2 B NM_011290 Rpl6 B NM_023912 Scyl1 B NM_011291 Rpl7 B NM_028776 Scyl3 B NM_012053 Rpl8 B NM_028725 Sdr42e1 B NM_018853 Rplp1 B NM_027301 Sdr9c7 B NM_133982 Rpp25 B NM_019934 Sec1 B NM_144861 Rprd1a B NM_028777 Sec14l1 B NM_026533 Rps13 B NM_001029937 Sec14l3 B NM_009091 Rps15 B NM_146013 Sec14l4 B NM_023133 Rps19 B NM_153125 Sec16a B NM_024175 Rps23 B NM_133704 Sec22a B NM_011297 Rps24 B NM_011342 Sec22b B NM_009095 Rps5 B NM_009147 Sec23a B NM_019924 Rps6ka4 B NM_027016 Sec62 B NM_025949 Rps6ka6 B NM_029279 Secisbp2 B NM_178775 Rps6kc1 B NM_001039089 Sel1l B NM_029767 Rps9 B NM_019414 Selenbp2 B NM_011029 Rpsa B NM_019979 Selk B NM_009100 Rptn B NM_053267 Selm B NM_173450 Rpusd2 B NM_011347 Selp B NM_178376 Rraga B NM_009152 Sema3a B NM_001004154 Rragb B NM_009153 Sema3b B NM_017475 Rragc B NM_011349 Sema3f B NM_009101 Rras B NM_001126047 Sema4c B NM_001039188 Rreb1 B NM_009154 Sema5a B NM_001039521 Rrn3 B NM_175400 Sephs1 B NM_028244 Rrp1b B NM_009266 Sephs2 B NM_025897 Rrp8 B NM_172490 Sepsecs B NM_145620 Rrp9 B NM_001009818 Sept11 B NM_011302 Rs1 B NM_019942 Sept6 B NM_023544 Rsc1a1 B NM_001113487 Sept9 B NM_001083945 Rsph3b B NM_013759 Sepx1 B NM_001159671 Rsph6a B NM_030685 Serp1 B NM_184109 Rtl1 B NM_008458 Serpina3c B NM_013648 Rtn2 B NM_001033335 Serpina3f B NM_130892 Rtn4ip1 B NM_009251 Serpina3g B NM_001004151 Rtp1 B NM_011458 Serpina3k B NM_016759 Rundc3a B NM_007618 Serpina6 B NM_001146038 Runx2 B NM_001160307 Serpinb10-ps B NM_011304 Ruvbl2 B NM_009126 Serpinb3a B NM_011305 Rxra B NM_198680 Serpinb3b B NM_011306 Rxrb B NM_080844 Serpinc1 B NM_001159731 Rxrg B NM_008871 Serpine1 B NM_011311 S100a4 B NM_009255 Serpine2 B NM_009789 S100g B NM_011340 Serpinf1 B NM_011316 Saa4 B NM_001111044 Serpinh1 B NM_021390 Sall1 B NM_053099 Setbp1 B NM_172676 Samd10 B NM_178029 Setd1a B NM_146025 Samd14 B NM_028385 Setd5 B NM_177271 Samd5 B NM_031179 Sf3b1 B NM_023380 Samsn1 B NM_030109 Sf3b2 B NM_021788 Sap30 B NM_133953 Sf3b3 B NM_001081168 Sap30l B NM_023603 Sfpq B NM_172795 Sarm1 B NM_016687 Sfrp4 B NM_016882 Sart1 B NM_026006 Sft2d3 B NM_028773 Sash3 B NM_009160 Sftpd B NM_028349 Sass6 B NM_009161 Sgca B NM_009121 Sat1 B NM_011890 Sgcb B NM_183426 Sbno2 B NM_011891 Sgcd B NM_001008422 Scaf1 B NM_001161849 Sgk1 B NM_178923 Scaf4 B NM_030750 Sgpp1 B NM_020255 Scand1 B NM_197943 Sgsm2 B NM_001103162 Scap B NM_021309 Sh2d2a B NM_001114660 Scfd2 B NM_172507 Sh3bgrl2 B NM_001113420 Schip1 B NM_011894 Sh3bp5 B NM_001081411 Sclt1 B NM_139302 Sh3glb2 B NM_013883 Scmh1 B NM_001135727 Sh3kbp1 B NM_018733 Scn1a B NM_008018 Sh3pxd2a B NM_001099298 Scn2a1 B NM_177364 Sh3pxd2b B NM_133199 Scn4a B NM_021506 Sh3rf1 B NM_001013390 Scn4b B NM_001146299 Sh3rf2 B

36

NM_172788 Sh3rf3 B NM_013901 Slc39a1 B NM_025340 Sharpin B NM_001135152 Slc39a14 B NM_001033306 Shb B NM_001039676 Slc39a2 B NM_011368 Shc1 B NM_028051 Slc39a5 B NM_199022 Shc4 B NM_139143 Slc39a6 B NM_009169 Shfm1 B NM_026228 Slc39a8 B NM_001033415 Shisa3 B NM_173865 Slc41a1 B NM_028230 Shmt2 B NM_027868 Slc41a3 B NM_013665 Shox2 B NM_173388 Slc43a2 B NM_001128093 Siah3 B NM_021398 Slc43a3 B NM_023059 Sigirr B NM_001159633 Slc44a1 B NM_010831 Sik1 B NM_021053 Slc46a2 B NM_027498 Sik3 B NM_001033542 Slc47a2 B NM_025679 Sike1 B NM_009207 Slc4a2 B NM_011377 Sim2 B NM_018760 Slc4a4 B NM_011378 Sin3a B NM_009057 Slc50a1 B NM_025656 Sip1 B NM_001003915 Slc5a12 B NM_007547 Sirpa B NM_133254 Slc5a2 B NM_001081137 Sis B NM_172890 Slc6a11 B NM_009189 Six1 B NM_175328 Slc6a15 B NM_018773 Skap2 B NM_010020 Slc6a3 B NM_028151 Skiv2l2 B NM_001146013 Slc6a5 B NM_172446 Skor1 B NM_011405 Slc7a7 B NM_001109743 Skor2 B NM_080440 Slc8a3 B NM_011543 Skp1a B NM_001081060 Slc9a3 B NM_009192 Sla B NM_023449 Slc9a3r2 B NM_001113423 Slain2 B NM_177084 Slc9a4 B NM_011387 Slc10a1 B NM_130861 Slco1a5 B NM_145406 Slc10a3 B NM_021471 Slco1c1 B NM_001079690 Slc12a1 B NM_033314 Slco2a1 B NM_172892 Slc13a4 B NM_175316 Slco2b1 B NM_001004148 Slc13a5 B NM_177570 Slfnl1 B NM_053079 Slc15a1 B NM_001161431 Slitrk2 B NM_177787 Slc15a5 B NM_198864 Slitrk3 B NM_172371 Slc16a13 B NM_178740 Slitrk4 B NM_027921 Slc16a14 B NM_025531 Slmo2 B NM_146136 Slc16a4 B NM_029420 Slx1b B NM_144836 Slc17a2 B NM_010754 Smad2 B NM_182959 Slc17a8 B NM_008541 Smad5 B NM_021712 Slc18a3 B NM_001042660 Smad7 B NM_030556 Slc19a3 B NM_174992 Smagp B NM_146255 Slc1a7 B NM_028534 Smap1 B NM_009203 Slc22a12 B NM_133716 Smap2 B NM_198650 Slc22a20 B NM_053123 Smarca1 B NM_144856 Slc22a7 B NM_026003 Smarca2 B NM_144813 Slc24a1 B NM_011418 Smarcb1 B NM_172152 Slc24a4 B NM_031842 Smarcd1 B NM_175034 Slc24a5 B NM_001130187 Smarcd2 B NM_013770 Slc25a10 B NM_025695 Smc6 B NM_024211 Slc25a11 B NM_178719 Smcr7l B NM_172436 Slc25a12 B NM_001005507 Smg7 B NM_015829 Slc25a13 B NM_011420 Smn1 B NM_011399 Slc25a17 B NM_172429 Smndc1 B NM_001013780 Slc25a34 B NM_176996 Smo B NM_026331 Slc25a37 B NM_009213 Smpd2 B NM_026542 Slc25a39 B NM_021491 Smpd3 B NM_007450 Slc25a4 B NM_021289 Smr2 B NM_001012310 Slc25a47 B NM_027885 Smug1 B NM_021353 Slc26a3 B NM_025481 Smurf2 B NM_011867 Slc26a4 B NM_011428 Snap25 B NM_134420 Slc26a6 B NM_178392 Snapc1 B NM_011978 Slc27a2 B NM_133854 Snapin B NM_011988 Slc27a3 B NM_175692 Snhg11 B NM_011989 Slc27a4 B NM_030093 Snrnp25 B NM_009512 Slc27a5 B NM_021336 Snrpa1 B NM_001004184 Slc28a1 B NM_009226 Snrpd1 B NM_178934 Slc2a12 B NM_009229 Sntb2 B NM_001033633 Slc2a13 B NM_027671 Sntg1 B NM_175090 Slc31a1 B NM_177624 Sntn B NM_009508 Slc32a1 B NM_028965 Snx11 B NM_021435 Slc35b4 B NM_001014973 Snx13 B NM_153170 Slc36a2 B NM_001025612 Snx22 B NM_028123 Slc37a3 B NM_025712 Snx31 B NM_023805 Slc38a3 B NM_175483 Snx33 B

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NM_080557 Snx4 B NM_021465 Stag2 B NM_146064 Soat2 B NM_024239 Stambp B NM_007706 Socs2 B NM_009283 Stat1 B NM_007707 Socs3 B NM_175096 Stbd1 B NM_011435 Sod3 B NM_001103156 Steap2 B NM_001034964 Sorbs1 B NM_019442 Stk19 B NM_025696 Sorcs3 B NM_019635 Stk3 B NM_019972 Sort1 B NM_022416 Stk32b B NM_001135559 Sos2 B NM_016866 Stk39 B NM_177753 Sox21 B NM_026942 Stoml1 B NM_173384 Sox30 B NM_153156 Stoml3 B NM_011447 Sox8 B NM_029858 Ston1 B NM_175397 Sp110 B NM_001114311 Stox2 B NM_001013817 Sp140 B NM_001162475 Stra6 B NM_001005343 Sp9 B NM_080459 Strc B NM_027055 Spaca4 B NM_011500 Strn B NM_001085393 Spaca5 B NM_024222 Stt3b B NM_153115 Spag11a B NM_144552 Stxbp6 B NM_172561 Spag7 B NM_011294 Sub1 B NM_001007463 Spag8 B NM_028072 Sulf2 B NM_010097 Sparcl1 B NM_019878 Sult1b1 B NM_027617 Spata1 B NM_009460 Sumo1 B NM_001045531 Spata22 B NM_194342 Sun2 B NM_178914 Spata7 B NM_009296 Supt4h1 B NM_027649 Spats1 B NM_001162913 Susd2 B NM_027641 Spef1 B NM_144796 Susd4 B NM_028855 Spem1 B NM_011514 Suv39h1 B NM_019763 Spen B NM_022724 Suv39h2 B NM_001144987 Spg20 B NM_022030 Sv2a B NM_020011 Sphk2 B NM_153153 Svil B NM_030061 Spink12 B NM_001160345 Svip B NM_009258 Spink3 B NM_178765 Sybu B NM_030058 Spint4 B NM_027954 Syce2 B NM_009260 Spnb2 B NM_023485 Sync B NM_023712 Spns1 B NM_001079686 Syne1 B NM_182927 Spred3 B NM_001113351 Synj2 B NM_011478 Sprr3 B NM_001109975 Synpo B NM_011896 Spry1 B NM_028052 Synpr B NM_011897 Spry2 B NM_009305 Syp B NM_013539 Spsb2 B NM_025575 Sys1 B NM_009270 Sqle B NM_009306 Syt1 B NM_021507 Sqrdl B NM_018804 Syt11 B NM_011018 Sqstm1 B NM_138649 Syt17 B NM_025291 Sra1 B NM_009307 Syt2 B NM_025691 Srp72 B NM_009308 Syt4 B NM_016795 Srpk1 B NM_016908 Syt5 B NM_009274 Srpk2 B NM_018801 Syt7 B NM_019684 Srpk3 B NM_001040086 Sytl2 B NM_026130 Srpr B NM_001008429 Taar3 B NM_016911 Srpx B NM_001010831 Taar9 B NM_001083895 Srpx2 B NM_138667 Tab2 B NM_016799 Srrm1 B NM_025729 Tab3 B NM_021403 Srrm3 B NM_199323 Tacc1 B NM_001109909 Srrt B NM_001040435 Tacc3 B NM_020587 Srsf4 B NM_027346 Taco1 B NM_025573 Srsf9 B NM_021382 Tacr3 B NM_001161369 Ss18 B NM_001081008 Taf1 B NM_178750 Ss18l1 B NM_026836 Taf11 B NM_080558 Ssfa2 B NM_001081288 Taf2 B NM_198113 Ssh3 B NM_027592 Taf9 B NM_023464 Ssna1 B NM_011529 Tank B NM_025448 Ssr2 B NM_144825 Taok1 B NM_009279 Ssr4 B NM_173764 Tapt1 B NM_182990 Ssrp1 B NM_177363 Tarm1 B NM_020491 Sssca1 B NM_027931 Tars2 B NM_009215 Sst B NM_020503 Tas2r119 B NM_011425 Sstr5 B NM_001025385 Tas2r137 B NM_009176 St3gal3 B NM_001001452 Tas2r143 B NM_001001326 St5 B NM_146214 Tat B NM_145933 St6gal1 B NM_175151 Tatdn1 B NM_012028 St6galnac5 B NM_029564 Tax1bp3 B NM_153091 St7l B NM_178650 Tbc1d10c B NM_138672 Stab1 B NM_172443 Tbc1d16 B NM_138673 Stab2 B NM_001042655 Tbc1d17 B

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NM_144517 Tbc1d19 B NM_181540 Tm6sf2 B NM_028854 Tbc1d21 B NM_181820 Tmc4 B NM_026254 Tbc1d23 B NM_181856 Tmc8 B NM_019786 Tbk1 B NM_001081312 Tmco2 B NM_013684 Tbp B NM_172282 Tmco3 B NM_011533 Tbx10 B NM_029857 Tmco4 B NM_020496 Tbx20 B NM_028036 Tmco6 B NM_011536 Tbx4 B NM_026775 Tmed10 B NM_011539 Tbxas1 B NM_028876 Tmed5 B NM_001082976 Tc2n B NM_025458 Tmed6 B NM_001159750 Tcea1 B NM_178638 Tmem108 B NM_146236 Tceal1 B NM_134142 Tmem109 B NM_025703 Tceal8 B NM_028839 Tmem110 B NM_013736 Tceb3 B NM_175101 Tmem111 B NM_053085 Tcf23 B NM_019704 Tmem115 B NM_011547 Tcfap2a B NM_133739 Tmem123 B NM_001025305 Tcfap2b B NM_175145 Tmem127 B NM_031198 Tcfec B NM_026698 Tmem129 B NM_013686 Tcp1 B NM_133804 Tmem132a B NM_013687 Tcp11 B NM_175432 Tmem132c B NM_022311 Tcte2 B NM_028411 Tmem138 B NM_175030 Tctex1d4 B NM_027215 Tmem147 B NM_001002238 Tdrd1 B NM_144916 Tmem150a B NM_011567 Tead4 B NM_182841 Tmem150c B NM_009348 Tectb B NM_001001885 Tmem151a B NM_013690 Tek B NM_177260 Tmem154 B NM_199455 Tepp B NM_175187 Tmem161b B NM_009352 Terf1 B NM_026198 Tmem167b B NM_009353 Terf2 B NM_175564 Tmem169 B NM_001040400 Tet2 B NM_001025606 Tmem171 B NM_172304 Tex10 B NM_172608 Tmem184b B NM_198292 Tex2 B NM_028427 Tmem192 B NM_009357 Tex261 B NM_199199 Tmem199 B NM_001126488 Tex28 B NM_001033759 Tmem2 B NM_146074 Tfb1m B NM_001025106 Tmem201 B NM_008249 Tfb2m B NM_178388 Tmem202 B NM_031199 Tgfa B NM_001001183 Tmem204 B NM_009367 Tgfb2 B NM_177175 Tmem215 B NM_001013025 Tgfbrap1 B NM_026798 Tmem216 B NM_173396 Tgif2 B NM_177392 Tmem220 B NM_001161714 Tgm1 B NM_025791 Tmem223 B NM_009374 Tgm3 B NM_001101546 Tmem233 B NM_177911 Tgm4 B NM_027865 Tmem25 B NM_028799 Tgm5 B NM_028766 Tmem43 B NM_177726 Tgm6 B NM_138751 Tmem47 B NM_054089 Tgs1 B NM_028264 Tmem55a B NM_011580 Thbs1 B NM_144794 Tmem63a B NM_025416 Them5 B NM_172583 Tmem63c B NM_178666 Themis B NM_181401 Tmem64 B NM_178413 Thnsl2 B NM_177670 Tmem69 B NM_011568 Thoc4 B NM_175502 Tmem74 B NM_172438 Thoc5 B NM_026519 Tmem85 B NM_009379 Thpo B NM_001033394 Tmem88b B NM_178060 Thra B NM_001160145 Tmem9 B NM_172444 Thsd4 B NM_025318 Tmem93 B NM_011585 Tia1 B NM_133706 Tmem97 B NM_011878 Tiam2 B NM_021883 Tmod1 B NM_173394 Ticam2 B NM_001080130 Tmpo B NM_001146325 Tigit B NM_177162 Tmprss11g B NM_011589 B NM_027902 Tmprss6 B NM_013899 Timm10 B NM_172455 Tmprss7 B NM_011591 Timm17b B NM_198967 Tmtc1 B NM_011595 Timp3 B NM_028651 Tmtc4 B NM_028751 Tjap1 B NM_009398 Tnfaip6 B NM_027249 Tlcd2 B NM_001033535 Tnfaip8l3 B NM_011602 Tln1 B NM_013869 Tnfrsf19 B NM_205823 Tlr12 B NM_178589 Tnfrsf21 B NM_126166 Tlr3 B NM_009401 Tnfrsf8 B NM_133211 Tlr7 B NM_033622 Tnfsf13b B NM_133212 Tlr8 B NM_001163007 Tnik B NM_178056 Tm2d3 B NM_001081260 Tnks1bp1 B NM_025453 Tm4sf20 B NM_022322 Tnmd B NM_145539 Tm4sf4 B NM_009393 Tnnc1 B NM_029360 Tm4sf5 B NM_009406 Tnni3 B

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NM_177066 Tnni3k B NM_025982 Tspan31 B NM_011618 Tnnt1 B NM_019571 Tspan5 B NM_013694 Tnp2 B NM_019656 Tspan6 B NM_001122730 Tnrc18 B NM_019634 Tspan7 B NM_144812 Tnrc6b B NM_030203 Tspyl4 B NM_198022 Tnrc6c B NM_177325 Tsr1 B NM_026654 Toe1 B NM_175146 Tsr2 B NM_025996 Tomm34 B NM_001024856 Ttbk2 B NM_001081679 Tomt B NM_172770 Ttc12 B NM_009408 Top1 B NM_145607 Ttc13 B NM_011623 Top2a B NM_177384 Ttc16 B NM_152800 Tor2a B NM_028360 Ttc19 B NM_145711 Tox B NM_025905 Ttc23 B NM_011627 Tpbg B NM_029321 Ttc32 B NM_009413 Tpd52l1 B NM_138951 Ttc36 B NM_025482 Tpd52l2 B NM_028417 Ttc9b B NM_009415 Tpi1 B NM_178869 Ttll1 B NM_013861 Tpk1 B NM_028921 Ttll11 B NM_024427 Tpm1 B NM_001014974 Ttll4 B NM_022314 Tpm3 B NM_172818 Ttll8 B NM_009418 Tpp2 B NM_013697 Ttr B NM_001128634 Tppp2 B NM_021885 Tub B NM_026481 Tppp3 B NM_011653 Tuba1a B NM_133780 Tpr B NM_009447 Tuba4a B NM_011906 Tpra1 B NM_001080971 Tubb1 B NM_175165 Tprg B NM_009450 Tubb2a B NM_012034 Tpsg1 B NM_023279 Tubb3 B NM_001033161 Tradd B NM_146116 Tubb4b B NM_009421 Traf1 B IgH NM_011655 Tubb5 B NM_011633 Traf5 B NM_028006 Tube1 B NM_011634 Traip B NM_172745 Tufm B NM_175114 Trak1 B NM_054040 Tulp4 B NM_146140 Tram1l1 B NM_177709 Tusc5 B NM_198297 Trat1 B NM_011658 Twist1 B NM_021406 Trem1 B NM_007855 Twist2 B NM_031254 Trem2 B NM_138628 Txlnb B NM_027763 Treml1 B NM_011660 Txn1 B NM_011637 Trex1 B NM_029582 Txndc11 B NM_133977 Trf B NM_025334 Txndc12 B NM_013696 Trhr B NM_026559 Txndc17 B NM_144551 Trib2 B NM_172054 Txndc9 B NM_175093 Trib3 B NM_001042408 Txnl4a B NM_030731 Trim23 B NM_175646 Txnl4b B NM_023655 Trim29 B NM_001042523 Txnrd1 B NM_145377 Trim41 B NM_153162 Txnrd3 B NM_020267 Trim44 B NM_011661 Tyr B NM_001081281 Trim55 B NM_133671 U2af2 B NM_201373 Trim56 B NM_009457 Uba1 B NM_198012 Trim68 B NM_001111106 Uba3 B NM_053100 Trim8 B NM_177823 Ubash3a B NM_001081302 Trio B NM_176860 Ubash3b B NM_027182 Trip13 B NM_009455 Ube2e1 B NM_011639 Trip6 B NM_009454 Ube2e3 B NM_198020 Trmt1 B NM_019803 Ube2g2 B NM_175113 Trmt6 B NM_016786 Ube2k B NM_027925 Trnau1ap B NM_145578 Ube2m B NM_001081156 Trnp1 B NM_180600 Ube2q2 B NM_019548 Tro B NM_145400 Ube4a B NM_011643 Trpc1 B NM_026842 Ubqln1 B NM_018752 Trpm1 B NM_033526 Ubqln4 B NM_175130 Trpm4 B NM_198624 Ubqlnl B NM_153417 Trpm6 B NM_177783 Ubr3 B NM_021450 Trpm7 B NM_001112721 Ubr5 B NM_153597 Trpt1 B NM_173784 Ubtd2 B NM_001001445 Trpv1 B NM_011670 Uchl1 B NM_145099 Trpv3 B NM_026765 Uckl1 B NM_001007572 Trpv5 B NM_138668 Ufsp2 B NM_011646 Try4 B NM_201644 Ugt1a9 B NM_022887 Tsc1 B NM_010633 Uhmk1 B NM_009366 Tsc22d1 B NM_009471 Umps B NM_001081300 Tshz1 B NM_001081153 Unc13c B NM_173007 Tspan12 B NM_133952 Unc45a B NM_027533 Tspan2 B NM_009472 Unc5c B NM_019793 Tspan3 B NM_153135 Unc5d B

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NM_001081017 Unc79 B NM_011712 Wbp5 B NM_013702 Uncx B NM_029274 Wbp7 B NM_009474 Uox B NM_029681 Wbscr28 B NM_133995 Upb1 B NM_172882 Wdfy3 B NM_001081132 Upf2 B NM_145425 Wdpcp B NM_175309 Upk3b B NM_172255 Wdr11 B NM_025650 Uqcr11 B NM_026137 Wdr13 B NM_025352 Uqcrq B NM_173741 Wdr24 B NM_144940 Uroc1 B NM_175173 Wdr27 B NM_009478 Urod B NM_144863 Wdr36 B NM_176847 Ush1g B NM_020603 Wdr46 B NM_021408 Ush2a B NM_080848 Wdr5 B NM_023211 Usmg5 B NM_026898 Wdr53 B NM_019490 Uso1 B NM_026464 Wdr55 B NM_011909 Usp18 B NM_031392 Wdr6 B NM_013919 Usp21 B NM_026399 Wdr83 B NM_013918 Usp25 B NM_029440 Wdr95 B NM_001029934 Usp32 B NM_001012723 Wfdc16 B NM_001033528 Usp36 B NM_145369 Wfdc5 B NM_176972 Usp37 B NM_028640 Whrn B NM_138592 Usp39 B NM_001081269 Whsc1l1 B NM_029749 Usp42 B NM_145940 Wipi1 B NM_133758 Usp47 B NM_026582 Wls B NM_001137547 Usp51 B NM_009518 Wnt10a B NM_001080548 Usp6nl B NM_053116 Wnt16 B NM_009482 Utf1 B NM_009522 Wnt3a B NM_028276 Utp14a B NM_009524 Wnt5a B NM_178918 Utp15 B NM_009528 Wnt7b B NM_175158 Utp20 B NM_009290 Wnt8a B NM_011910 Uts2 B NM_144783 Wt1 B NM_198166 Uts2d B NM_001113532 Wtap B NM_013933 Vapa B NM_133791 Wwc2 B NM_019806 Vapb B NM_011723 Xdh B NM_175137 Vars2 B NM_023500 Xk B NM_009499 Vasp B NM_001035226 Xpo1 B NM_011691 Vav1 B NM_028198 Xpo5 B NM_009500 Vav2 B NM_011273 Xpr1 B NM_009501 Vax1 B NM_020570 Xrcc2 B NM_011693 Vcam1 B NM_009533 Xrcc5 B NM_009503 Vcp B NM_011917 Xrn2 B NM_011696 Vdac3 B NM_009535 Yes1 B NM_009505 Vegfa B NM_026553 Yif1a B NM_009507 Vhl B NM_145353 Yipf3 B NM_011702 Vip B NM_023311 Yipf5 B NM_134044 Vipar B NM_023784 Yipf7 B NM_009511 Vipr2 B NM_019661 Ykt6 B NM_028813 Vit B NM_025347 Ypel3 B NM_001161420 Vldlr B NM_145393 Ythdf2 B NM_134213 Vmn1r199 B NM_009537 Yy1 B NM_001104592 Vmn2r2 B NM_146090 Zadh2 B NM_001104615 Vmn2r4 B NM_009539 Zap70 B NM_001104618 Vmn2r5 B NM_174877 Zar1 B NM_001104619 Vmn2r6 B NM_172515 Zbbx B NM_175674 Vmn2r7 B NM_020625 Zbtb22 B NM_029478 Vmp1 B NM_199025 Zbtb26 B NM_177184 Vps13c B NM_175537 Zbtb38 B NM_172269 Vps18 B NM_198035 Zbtb39 B NM_019780 Vps29 B NM_198248 Zbtb40 B NM_181403 Vps37c B NM_010731 Zbtb7a B NM_177574 Vps37d B NM_145356 Zbtb7c B NM_172120 Vps41 B NM_001005916 Zbtb9 B NM_030181 Vsig1 B NM_153159 Zc3h12a B NM_177789 Vsig4 B NM_001162921 Zc3h12c B NM_177723 Vsig8 B NM_026934 Zc3h15 B NM_145967 Vstm2a B NM_029158 Zcchc13 B NM_054068 Vsx1 B NM_001033795 Zcchc16 B NM_178594 Vtcn1 B NM_153160 Zcchc17 B NM_011707 Vtn B NM_025893 Zcchc18 B NM_177697 Vwa3a B NM_153538 Zcchc6 B NM_182636 Vwa5b2 B NM_175160 Zdhhc1 B NM_027913 Vwce B NM_146073 Zdhhc14 B NM_028459 Wasl B NM_175358 Zdhhc15 B NM_001083922 Wbp1 B NM_023740 Zdhhc16 B NM_029066 Wbp2nl B NM_178395 Zdhhc2 B

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NM_001080943 Zdhhc22 B NM_144516 Zmynd11 B NM_133967 Zdhhc7 B NM_001014900 Zmynd12 B NM_025512 Zfand1 B NM_026021 Zmynd19 B NM_001159906 Zfand2b B NM_027230 Zmynd8 B NM_009551 Zfand5 B NM_133206 Znrf1 B NM_001145888 Zfat B NM_199143 Znrf2 B NM_001039198 Zfhx2 B NM_015785 Zpbp B NM_007496 Zfhx3 B NM_178720 Zpld1 B NM_009544 Zfp105 B NM_016684 Zscan12 B NM_029888 Zfp142 B NM_026507 Zwilch B NM_011980 Zfp146 B NM_011777 Zyx B NM_009547 Zfp161 B NM_001045536 Zzef1 B NM_026450 Zfp169 B NM_001080755 Zzz3 B NM_001013786 Zfp187 B NM_139141 Zfp192 B NM_001033496 Zfp213 B NM_027248 Zfp219 B NM_011752 Zfp259 B NM_011981 Zfp260 B NM_031494 Zfp275 B NM_001160251 Zfp281 B NM_138949 Zfp286 B NM_133208 Zfp287 B NM_009329 Zfp354a B NM_013744 Zfp354b B NM_001081098 Zfp362 B NM_009554 Zfp37 B NM_027007 Zfp397 B NM_001033451 Zfp408 B NM_033327 Zfp423 B NM_146183 Zfp428 B NM_175558 Zfp446 B NM_030139 Zfp449 B NM_133817 Zfp451 B NM_009557 Zfp46 B NM_172867 Zfp462 B NM_001085417 Zfp467 B NM_145459 Zfp503 B NM_172993 Zfp512 B NM_028319 Zfp518a B NM_172617 Zfp523 B NM_175436 Zfp526 B NM_001033355 Zfp568 B NM_175477 Zfp574 B NM_001033159 Zfp597 B NM_172536 Zfp609 B NM_028326 Zfp618 B NM_170759 Zfp628 B NM_026856 Zfp644 B NM_201609 Zfp652 B NM_028059 Zfp654 B NM_001083958 Zfp655 B NM_028141 Zfp661 B NM_001081750 Zfp664 B NM_001145935 Zfp691 B NM_175433 Zfp710 B NM_177747 Zfp711 B NM_175466 Zfp770 B NM_175513 Zfp804a B NM_029468 Zfp821 B NM_009569 Zfpm1 B NM_011766 Zfpm2 B NM_011767 Zfr B NM_001044386 Zfx B NM_028054 Zfyve19 B NM_001008550 Zfyve26 B NM_026918 Zg16 B NM_009576 Zic4 B NM_001081329 Zkscan2 B NM_025594 Zmat2 B NM_009517 Zmat3 B NM_001005867 Zmiz2 B NM_001114399 Zmym4 B NM_053253 Zmynd10 B

42