DOCSLIB.ORG

Neue Drogen – Neue Therapie? Crystal Speed, ATS &

Total Page：16

File Type：pdf, Size：1020Kb

Download full-text PDF Read full-text
Neue Drogen – Neue Therapie? Crystal Speed, ATS & Neue Drogen – neue Therapie? Crystal Speed, ATS & NPS Arbeitsgruppe / Workshop auf der Buss-Jahrestagung am 12.03.2014 Dipl.-Psych. Marcus Breuer psycholog. Psychotherapeut Begriffsklärung • Crystal = Crystal Speed; kristallines Metamphetamin • ATS = Amphetamin Type Stimulants • NPS = New Psychoactive Substances • Badesalze = Szenebezeichnung, denkbar ungeeignet, weil sie nichts erklärt und außerdem verharmlost • Research Chemicals = diese Stoffe sind „Abfallprodukte“ aus der Medikamentenentwicklung oder aber gezielte Veränderungen bekannter psychoaktiver Substanzen • Legal Highs = viele dieser neuen Stoffe sind bzw. waren zunächst legal (nicht dem BtmG unterstellt) • Kräutermischungen = Spice & Co., rauchbare synthetische Cannabinoide (viel toxischer als Cannabis) Definition ATS • engl.: Amphetamine-Type-Stimulants • Amphetaminartige Substanzen, die eine ähnliche Ringstruktur haben wie das „klassische“ Amphetamin • Aber: unterschiedliche Wirkung….. Wirkbogen der Partydrogen Entaktogene Ecstasy-MDMA MDEE Häufigkeit • ATS= Amphetamine Type Stimulants • Amphetamin (Speed) • XTC (MDMA; MDE; MDA) • Methamphetamin (Crystal) • Weltweit zusammen 26 million “regular users” vs: • Kokain 14 million reg. users • Heroin 16 million reg. users Nach WHO and UNODOC-Schätzungen (2010) ist Methamphetamin weltweit alleine die nach CANNABIS am häufigsten konsumierte illegale Substanz(18 Mio) (Nikotin und Alkohol sind Hauptproblem…..) Gesamtzahlen erstauffällige Konsumenten nach BKA: Trend 2000-2009 Drogentrends ATS – Geschichte I - 1800 Ephedrin erstmalig aus Pflanze isoliert - 1801 Kokain isoliert - Ephedra als Asthmamittel - 1893 d-Amphetamin erstmals in Japan synthetisiert - WW I Ephedra reduziert verfügbar - 1927 Einsatz eines Derivates als Asthmatherapeutikum - 1937 erstmals Missbrauch beschrieben - 1938 erste Amphetaminpsychose beschrieben - Meth: Angeblich Hitler im Führerbunker, Rommel in Wüste; angeblich deutsche Flieger „Hitler-Speed“- „Panzerschokolade“ -> Methamphetamin / Pervitin - Angriff auf Pearl Harbour unter Methamphetamin - gesichert: 1946 erste „Crystalwelle“ in Japan Quelle: Dr. Härtel-Petri, BKH Bayreuth, 2011/2012 ATS – Geschichte II (Medikamente) • 70er Jahre AN1, (auch Captagon) d-Amphetamin. Als Antidepressiva und gegen Schlafsucht und als Schlankheitsmittel… • „Braindoping der 68er“ • Ritalin kam in den 1950er Jahren auf den Markt und wurde schon in den 1960ern von vielen Menschen ohne medizinische Indikation eingenommen (z.B. Andy Warhol). • Kraftfahrer zur erhöhten Vigilanz (speed) D-amph: Jonny Cash, Elvis Presley, Fernfahrer…. Quelle: Dr. Härtel-Petri, BKH Bayreuth, 2011/2012 ATS – Geschichte III Insgesamt ist es eher verwunderlich, dass die 1. Welle nicht schon die Gesamt-BRD erreicht hatte! Woran lag das? Westdeutschlands Partydrogenszene wurde mit XTC und Speed (d-amphetamin) aus HOLLAND versorgt. Langsam zunehmend der Osten aus der Tschechischen Republik mit kleiner Verzögerung nach dem Zusammenbruch des Ostblocks…… mit Methamphetamin (Crystal-speed) Quelle: Dr. Härtel-Petri, BKH Bayreuth, 2011/2012 ATS – Geschichte IV Erste Zusammenfassung: Stimulantienthema eigentlich KEIN neuer Trend, …. aber die erneute Welle irgendwie schon …. ….. u.a. wegen Braindopingthematik Quelle: Dr. Härtel-Petri, BKH Bayreuth, 2011/2012 Crystal - Wirkung • WECKAMIN: wach machend, „Stimulierend“ • Schmerzempfindung reduzierend • Appetit zügelnd • Leistungsfähigkeit steigernd • Monotone Tätigkeiten • Selbstbewusstsein steigernd • SEX Antrieb und Genuss steigernd • Veränderung des Zeitempfindens • Stereotypien • Evtl. mit Kick (Euphorie), besonders bei i.v. und ice (geraucht) • HWZ= 8-24h (Urin-ph) Bis 48h wirksam! • Billiger als Kokain • Raschere Toleranzentwicklung • schneller abhängig (2), mehr Comorbidität (1), als bei Kokain! (2) Gonzalez Castro F, Barrington EH, Walton MA, Rawson RA.: Cocaine and methamphetamine: differential addictionrates Psychol Addict Behav 2000 Dec;14(4):390-396 (1) Kalechstein AD, Newton TF, Longshore D, Anglin MD, van Gorp WG, Gawin FH. Psychiatric comorbidity of methamphetamine dependence in a forensic sample. in J Neuropsychiatry Clin Neurosci 2000;12(4):480-484 ATS - Einnahme • Tabletten (bei Crystal selten, bei Speed/XTC häufig) • Nasal „lines“ • Intravenös: „ballern“, „spritzen“ und • „Ice rauchen“ - Schnellerer Wirkungseintritt • zunehmend schnellerer Wirkungseintritt -> mehr Comorbidität • Selten größere Menge schlucken „Bombe“ (z.B. bei Nasenbluten) Abhängigkeitsentwicklung: • Gelegenheitskonsum • Wochenendkonsum Freitag-Sa... mit /ohne Nachlegen? • Montag blau machen, Depressionen, Antriebsarmut. • Mittwoch „nachlegen“ zur Überbrückung bis Freitag..... • Täglicher oder Konsum jeden 2. Tag (Halbwertszeit bis 24h!) mit • rascher Toleranzentwicklung (Dosissteigerung) BINGES, SPEEDRUN: • Totaler Kontrollverlust bis keine Substanz mehr beschaffbar oder körperlicher Zusammenbruch Pharmakologie / Toxikologie (Uni Leipzig) Konsumformen und Wirkungseintritt: – oral (20-30 Min.) – nasal, überwiegend (5-10 Min.) – Rauchen (~ 1-3 Min.) – parenteral (i.v.) (< 1 Min.) Dosierung: therapeutische Dosis oral 3 mg pro/Tag: 10-30 mg, (3-10 Pervitin-Tabl.) Blutspiegel (therapeutisch): 10–50 ng/ml Wirkung 6-12 Stunden, Eliminations-Halbwertzeit: 9 -15 Std. Heutzutage: UNI LEIPZIG: Befunde aus 200 – 400 positiven Fällen pro Jahr (Verkehrskontrollen: Blutabnahmen): Blutspiegel bis > 2000 ng/ml Mittelwert ansteigend, derzeit ca. 300 ng/ml 10-50X höhere Konzentrationen im Blut…. „recreational user“ ? 1 line crystal-meth: 100-200mg 20-40x höhere Dosis abhängige Konsumenten mit Toleranz: 500-1000mg/Tag, oft bis 1500-2000mg (70-90% Wirkstoff) 10-100 X „therapeutische“ Dosis Toleranz tritt bereits auf nach 3 Dosierungen von 10 mg oral an 2-3 aufeinander folgenden Tagen! (10mg pro Tag!) (Hart et al. 2001) Also auch bei „Pervitin“ Abhängigkeit…. Konsumententypen • „Probierer / Gelegenheitskonsumenten“: Konsum wurde mangels Interesse oder wegen Nebenwirkungen / Risiko wieder eingestellt. • „Substituierer“: Illegale Drogen werden durch NPS ersetzt, etwa wegen eines bevorstehenden Drogenscreenings. • „Kiffer 2.0“: wechselnder Konsum von Cannabis und NPS, häufig werden Versorgungsengpässe mit Räuchermischungen überbrückt. • „Spezialisten“: experimentierfreudige „Psychonauten“, die das breitgefächerte Wirkspektrum von Research Chemicals nutzen. • „Allesnehmer“: regelmäßige Konsumenten unterschiedlicher Drogen, je nach Verfügbarkeit, Stimmung und Setting. Warum „explodiert“ das Thema derzeit so? • Tw. Sehr hohes Abhängigkeitspotential (je nach Substanz und Konsumart –> i.v./geraucht) • Leichte Verfügbarkeit • Leichte Herstellbarkeit • Internet als Informations- und Verbreitungsmedium • IIlegalisierungsproblem (viele verschiedene, neue Stoffe, Gruppenunterstellungsproblem im dt. BtmG) • Drogen werden zunehmend ortsnah produziert (d.h. in unserem Fall innerhalb Europas) -> minimiert die (Zoll)-Aufdeckungsgefahr • ATS „passen“ in unsere Zeit – schneller-höher-weiter ATS – Akute Schäden • Herzrhythmusstörungen • Bluthochdruckkrisen - cardiale Komplikationen • Schlaganfälle durch Bluthochdruckkrisen • Epileptische Anfälle • Akute Intoxikationspsychosen • Hyperthermie (akutes Medikamentenfieber mit Nierenversagen und Tod) Meth-Schäden: kurz- und langfristig • Schlaganfälle, Krampfanfälle, Kopfschmerzen • Gereiztheit, Unruhe • Depressionen, Ängstlichkeit, Reizbarkeit, Wut • Gedächtnisstörungen, Verwirrtheit (“Verpeiltheit”), Aufmerksamkeitsstörungen • Schlafstörungen/ Alpträume • Paranoia (Verfolgungsgedanken), akustische Halluzinationen (Stimmen hören), Panikreaktionen • Suizidgedanken (Selbstmordgedanken) • Nasennebenhöhleninfektionen • Verlust des Geruchssinnes, Nasenbluten, chronisches Naselaufen, • Heiserkeit • Trockener Mund, aufgesprungene Lippen • Abgenutzte Zähne und Karies (ständiges Knirschen- zu wenig Speichel-Mundreinigung vergessen) • Schluckbeschwerden • Brustschmerz, Husten und Atemstörungen (beim Entzug) • Herzrhythmusstörungen bis Herzinfarkt (Herzanfall) • Magendarmprobleme (Magenschmerzen und Übelkeit) • Libidoverlust (keine Lust auf Sex) • Mangelernährung, Unterernährung, Gewichtsverlust. • Schwäche, Müdigkeit • Tremor (Zittern) • Schwitzen • Fettige Haut, Pickel, aufgekratzte Stellen (Exkoriationen) • Muskelschmerzen und Rückenschmerzen Crystal - Entzug Problem: - Entzug nicht vegetativ, nicht körperlich sichtbar….. - wird (z.B. von Opiatpat. und vielen Kollegen) nicht ernst genommen…. - Suchtdruck (Craving), - Emot. Instabilität-Gereiztheit, - vermehrtes Schlafbedürfnis, dann unerholsamer Schlaf (DROGENTRÄUME) - Depressionen mit Suizidalität, - Antriebsmangel / Hyperkinet. Syndrom - Heißhungerattacken (Essstörungen) - Dauer: > 2-3 Wochen Crystal - Langzeitschäden Zusätzlich zu „suchttypischen“ Netzwerkveränderungen wie bei anderen Stoffen: NEUROTOXIZITÄT. • Nervenzellen sterben ab. Kognitive Störungen: • Gedächtnisstörungen, • Aufmerksamkeitsstörungen, • Konzentrationsstörungen. • (Unfähigkeit, sich an Termine zu erinnern) UND PSYCHOSEN! Speed - Psychose • Paranoid halluzinatorisch • „Filme schieben , Paranoia haben“ • (Verfolgungswahn) -> Gefahr des Konsums sedierender Substanzen als Selbstmedikationsversuch Exkurs: Research Chemicals I Neue Clubdrugs/Trenddrogen - fast alles RC-Drugs: • Substanzen, die zu Forschungszwecken genutzt werden und als solche „gekauft“ werden…. • RC-Substanzen (research chemicals) / Designerdrugs….. • Zeitweise nicht dem BTMG der jeweiligen Länder unterliegend….. • z.B. Mephedrone, Butylone etc….. 280 Substanzen! • Teilweise keine ATS, synthet. Kokainderivate… Exkurs: Research
Load more

Recommended publications
  • Nietzsche and Psychedelics – Peter Sjöstedt-H –
    Antichrist Psychonaut: Nietzsche and Psychedelics – Peter Sjöstedt-H – ‘… And close your eyes with holy dread, For he on honey-dew hath fed, And drunk the milk of Paradise.’ So ends the famous fragment of Kubla Khan by the Romantic poet, Samuel Taylor Coleridge. He tells us that the poem was an immediate transcription of an opium-induced dream he experienced in 1797. As is known, the Romantic poets and their kin were inspired by the use of psychoactive substances such as opium, the old world’s common pain reliever. Pain elimination is its negative advantage, but its positive attribute lies in the psychedelic (‘mind- revealing’)1 state it can engender – a state described no better than by the original English opium eater himself, Thomas De Quincey: O just and righteous opium! … thou bildest upon the bosom of darkness, out of the fantastic imagery of the brain, cities and temples, beyond the art of Phidias and Praxiteles – beyond the splendours of Babylon and Hekatómpylos; and, “from the anarchy of dreaming sleep,” callest into sunny light the faces of long-buried beauties … thou hast the keys of Paradise, O just, subtle, and mighty opium!2 Two decades following the publication of these words the First Opium War commences (1839) in which China is martially punished for trying to hinder the British trade of opium to the Chinese people. Though opium, derived from the innocent garden poppy Papavar somniferum, may cradle the keys to Paradise it also clutches the keys to Perdition: its addictive thus potentially ruinous nature is commonly known. Today, partly for these reasons, opiates are mostly illegal without license – stringently so in their most potent forms of morphine and heroin.
    [Show full text]
  • Enzymatic Encoding Methods for Efficient Synthesis Of
    (19) TZZ__T (11) EP 1 957 644 B1 (12) EUROPEAN PATENT SPECIFICATION (45) Date of publication and mention (51) Int Cl.: of the grant of the patent: C12N 15/10 (2006.01) C12Q 1/68 (2006.01) 01.12.2010 Bulletin 2010/48 C40B 40/06 (2006.01) C40B 50/06 (2006.01) (21) Application number: 06818144.5 (86) International application number: PCT/DK2006/000685 (22) Date of filing: 01.12.2006 (87) International publication number: WO 2007/062664 (07.06.2007 Gazette 2007/23) (54) ENZYMATIC ENCODING METHODS FOR EFFICIENT SYNTHESIS OF LARGE LIBRARIES ENZYMVERMITTELNDE KODIERUNGSMETHODEN FÜR EINE EFFIZIENTE SYNTHESE VON GROSSEN BIBLIOTHEKEN PROCEDES DE CODAGE ENZYMATIQUE DESTINES A LA SYNTHESE EFFICACE DE BIBLIOTHEQUES IMPORTANTES (84) Designated Contracting States: • GOLDBECH, Anne AT BE BG CH CY CZ DE DK EE ES FI FR GB GR DK-2200 Copenhagen N (DK) HU IE IS IT LI LT LU LV MC NL PL PT RO SE SI • DE LEON, Daen SK TR DK-2300 Copenhagen S (DK) Designated Extension States: • KALDOR, Ditte Kievsmose AL BA HR MK RS DK-2880 Bagsvaerd (DK) • SLØK, Frank Abilgaard (30) Priority: 01.12.2005 DK 200501704 DK-3450 Allerød (DK) 02.12.2005 US 741490 P • HUSEMOEN, Birgitte Nystrup DK-2500 Valby (DK) (43) Date of publication of application: • DOLBERG, Johannes 20.08.2008 Bulletin 2008/34 DK-1674 Copenhagen V (DK) • JENSEN, Kim Birkebæk (73) Proprietor: Nuevolution A/S DK-2610 Rødovre (DK) 2100 Copenhagen 0 (DK) • PETERSEN, Lene DK-2100 Copenhagen Ø (DK) (72) Inventors: • NØRREGAARD-MADSEN, Mads • FRANCH, Thomas DK-3460 Birkerød (DK) DK-3070 Snekkersten (DK) • GODSKESEN,
    [Show full text]
  • Neotrance and the Psychedelic Festival DC
    Neotrance and the Psychedelic Festival GRAHAM ST JOHN UNIVERSITY OF REGINA, UNIVERSITY OF QUEENSLAND Abstract !is article explores the religio-spiritual characteristics of psytrance (psychedelic trance), attending speci"cally to the characteristics of what I call neotrance apparent within the contemporary trance event, the countercultural inheritance of the “tribal” psytrance festival, and the dramatizing of participants’ “ultimate concerns” within the festival framework. An exploration of the psychedelic festival offers insights on ecstatic (self- transcendent), performative (self-expressive) and re!exive (conscious alternative) trajectories within psytrance music culture. I address this dynamic with reference to Portugal’s Boom Festival. Keywords psytrance, neotrance, psychedelic festival, trance states, religion, new spirituality, liminality, neotribe Figure 1: Main Floor, Boom Festival 2008, Portugal – Photo by jakob kolar www.jacomedia.net As electronic dance music cultures (EDMCs) flourish in the global present, their relig- ious and/or spiritual character have become common subjects of exploration for scholars of religion, music and culture.1 This article addresses the religio-spiritual Dancecult: Journal of Electronic Dance Music Culture 1(1) 2009, 35-64 + Dancecult ISSN 1947-5403 ©2009 Dancecult http://www.dancecult.net/ DC Journal of Electronic Dance Music Culture – DOI 10.12801/1947-5403.2009.01.01.03 + D DC –C 36 Dancecult: Journal of Electronic Dance Music Culture • vol 1 no 1 characteristics of psytrance (psychedelic trance), attending specifically to the charac- teristics of the contemporary trance event which I call neotrance, the countercultural inheritance of the “tribal” psytrance festival, and the dramatizing of participants’ “ul- timate concerns” within the framework of the “visionary” music festival.
    [Show full text]
  • (Title of the Thesis)*
    Dionysian Semiotics: Myco-Dendrolatry and Other Shamanic Motifs in the Myths and Rituals of the Phrygian Mother by Daniel Attrell A thesis presented to the University of Waterloo in fulfillment of the thesis requirement for the degree of Master of Arts in Ancient Mediterranean Cultures Waterloo, Ontario, Canada, 2013 © Daniel Attrell 2013 Author’s Declaration I hereby declare that I am the sole author of this thesis. This is a true copy of the thesis, including any required final revisions, as accepted by my examiners. I understand that my thesis may be made electronically available to the public. ii Abstract The administration of initiation rites by an ecstatic specialist, now known to western scholarship by the general designation of ‗shaman‘, has proven to be one of humanity‘s oldest, most widespread, and continuous magico-religious traditions. At the heart of their initiatory rituals lay an ordeal – a metaphysical journey - almost ubiquitously brought on by the effects of a life-changing hallucinogenic drug experience. To guide their initiates, these shaman worked with a repertoire of locally acquired instruments, costumes, dances, and ecstasy-inducing substances. Among past Mediterranean cultures, Semitic and Indo-European, these sorts of initiation rites were vital to society‘s spiritual well-being. It was, however, the mystery schools of antiquity – organizations founded upon conserving the secrets of plant-lore, astrology, theurgy and mystical philosophy – which satisfied the role of the shaman in Greco-Roman society. The rites they delivered to the common individual were a form of ritualized ecstasy and they provided an orderly context for religiously-oriented intoxication.
    [Show full text]
  • Daniel Bovet
    D ANIEL B OVET The relationships between isosterism and competitive phenomena in the field of drug therapy of the autonomic nervous system and that of the neuromuscular transmission Nobel Lecture, December 11, 1957 Putting to good use the vast possibilities which organic synthesis offers, a number of workers have directed their efforts towards applying it to thera- peutics, and have sought to establish the bases of a science of pharmaceutical chemistry, or, more exactly perhaps, the bases of a science of chemical pharmacology worthy of this name. If such an ambitious programme has not yet been fully realized, we are at least justified in recognizing, in the work which has now been in progress for fifty years, the appearance of a few guiding principles whose value has not ceased to assert itself. This is particularly true, for example, in the case of ideas in isosterism and com- petition. The origin of many drugs must be looked for in substances of a biological nature, and in particular in the alkaloids. The elucidation of their structure has been a starting-off point for chemists to synthesize similar compounds. Cocaine, atropine, and morphia are particularly good examples in this respect, since substances which are made like them have shown, clinically, local anaesthetic, antispasmodic, and marked analgesic properties, respective- ly. In each of these cases the physiological properties of the new compound seem to be similar to the compound to which it is structurally related. This has been verified in many other fields, but it is nevertheless evident that in certain cases, molecules which are chemically closely related have very dif- ferent and even antagonistic properties.
    [Show full text]
  • Application of High Resolution Mass Spectrometry for the Screening and Confirmation of Novel Psychoactive Substances Joshua Zolton Seither [email protected]
    Florida International University FIU Digital Commons FIU Electronic Theses and Dissertations University Graduate School 4-25-2018 Application of High Resolution Mass Spectrometry for the Screening and Confirmation of Novel Psychoactive Substances Joshua Zolton Seither [email protected] DOI: 10.25148/etd.FIDC006565 Follow this and additional works at: https://digitalcommons.fiu.edu/etd Part of the Chemistry Commons Recommended Citation Seither, Joshua Zolton, "Application of High Resolution Mass Spectrometry for the Screening and Confirmation of Novel Psychoactive Substances" (2018). FIU Electronic Theses and Dissertations. 3823. https://digitalcommons.fiu.edu/etd/3823 This work is brought to you for free and open access by the University Graduate School at FIU Digital Commons. It has been accepted for inclusion in FIU Electronic Theses and Dissertations by an authorized administrator of FIU Digital Commons. For more information, please contact [email protected]. FLORIDA INTERNATIONAL UNIVERSITY Miami, Florida APPLICATION OF HIGH RESOLUTION MASS SPECTROMETRY FOR THE SCREENING AND CONFIRMATION OF NOVEL PSYCHOACTIVE SUBSTANCES A dissertation submitted in partial fulfillment of the requirements for the degree of DOCTOR OF PHILOSOPHY in CHEMISTRY by Joshua Zolton Seither 2018 To: Dean Michael R. Heithaus College of Arts, Sciences and Education This dissertation, written by Joshua Zolton Seither, and entitled Application of High- Resolution Mass Spectrometry for the Screening and Confirmation of Novel Psychoactive Substances, having been approved in respect to style and intellectual content, is referred to you for judgment. We have read this dissertation and recommend that it be approved. _______________________________________ Piero Gardinali _______________________________________ Bruce McCord _______________________________________ DeEtta Mills _______________________________________ Stanislaw Wnuk _______________________________________ Anthony DeCaprio, Major Professor Date of Defense: April 25, 2018 The dissertation of Joshua Zolton Seither is approved.
    [Show full text]
  • Inner Visions: Sacred Plants, Art and Spirituality
    AM 9:31 2 12/10/14 2 224926_Covers_DEC10.indd INNER VISIONS: SACRED PLANTS, ART AND SPIRITUALITY Brauer Museum of Art • Valparaiso University Vision 12: Three Types of Sorcerers Gouache on paper, 12 x 16 inches. 1989 Pablo Amaringo 224926_Covers_DEC10.indd 3 12/10/14 9:31 AM 3 224926_Text_Dec12.indd 3 12/12/14 11:42 AM Inner Visions: Sacred Plants, Art and Spirituality • An Exhibition of Art Presented by the Brauer Museum • Curated by Luis Eduardo Luna 4 224926_Text.indd 4 12/9/14 10:00 PM Contents 6 From the Director Gregg Hertzlieb 9 Introduction Robert Sirko 13 Inner Visions: Sacred Plants, Art and Spirituality Luis Eduardo Luna 29 Encountering Other Worlds, Amazonian and Biblical Richard E. DeMaris 35 The Artist and the Shaman: Seen and Unseen Worlds Robert Sirko 73 Exhibition Listing 5 224926_Text.indd 5 12/9/14 10:00 PM From the Director In this Brauer Museum of Art exhibition and accompanying other than earthly existence. Additionally, while some objects publication, expertly curated by the noted scholar Luis Eduardo may be culture specific in their references and nature, they are Luna, we explore the complex and enigmatic topic of the also broadly influential on many levels to, say, contemporary ritual use of sacred plants to achieve visionary states of mind. American and European subcultures, as well as to contemporary Working as a team, Luna, Valparaiso University Associate artistic practices in general. Professor of Art Robert Sirko, Valparaiso University Professor We at the Brauer Museum of Art wish to thank the Richard E. DeMaris and the Brauer Museum staff present following individuals and agencies for making this exhibition our efforts of examining visual products arising from the possible: the Brauer Museum of Art’s Brauer Endowment, ingestion of these sacred plants and brews such as ayahuasca.
    [Show full text]
  • Psychedelics Again
    Interview with Sasha T. Shulgin in San Francisco (Lafayette) at his home on July, 11th 2001 Claus: The first time I hit upon your name, was when I became interested in 2,5- dimethoxy-4-methyl-amphetamine (STP, DOM), and found an article authored by yourself. Once I had found your name, I looked for other publications by "A. Shulgin". When I had found a few, I thought it rather strange, that some publications gave a DOW chemical company address, and other articles gave a private address in Shulgin Road, in Lafayette/CA. Alexander: Yes that is interesting, that was around 1968-1970. That was a funny period; I was at Medical School at San Francisco, University of California. I would be wandering through the Haight-Ashbury and everyone around me was stoned on either LSD or who knows what it was called, STP or whatever, that day. And the crowd was turned on: music, love, and happiness. And I was 3 blocks away, memorising the Circle of Willis, and I was wandering about not realizing that the stoned-ness around me that I had invented about 10 years earlier. I did not realize what STP was; I did not know it was DOM. It took 6 months to unravel that. Claus: Do you know that there was a rumour around the day of the festival; the day 2,5-dimethoxy-4-methyl-amphetamine hit the street for the first time, that this was a chemical that came from DOW Chemical Company? Alexander: I never heard that. That makes sense though: I gave a seminar at Johns Hopkins and I talked about the chemical and there were some scraggy people, long hair, beards, stoned.
    [Show full text]
  • Abstract Book 2012.Indd
    SUPPLEMENT TO JOURNAL OF PSYCHOPHARMACOLOGY VOL 26, SUPPLEMENT TO ISSUE 8, AUGUST 2012 These papers were presented at the Summer Meeting of the BRITISH ASSOCIATION FOR PSYCHOPHARMACOLOGY 22 – 25 July, Harrogate, UK Indemnity The scientific material presented at this meeting reflects the opinions of the contributing authors and speakers. The British Association for Psychopharmacology accepts no responsibility for the contents of the verbal or any published proceedings of this meeting. BAP OFFICE 36 Cambridge Place Hills Road Cambridge CB2 1NS bap.org.uk Aii CONTENTS Abstract Book 2012 Abstracts begin on page: SYMPOSIUM 1 A1 Drugs as tools in neuropsychiatry: Ketamine (S01-S04) SYMPOSIUM 2 A2 New tricks for old drugs: Opiates, addiction and beyond (S05-S08) SYMPOSIUM 3 A3 Advances in understanding brain corticosteroid responses to stress: relevance to depression (S09-S12) SYMPOSIUM 4 A5 Cognitive impairment in depression: A target for treatment? (S13-S16) SYMPOSIUM 5 A6 New treatment strategies for targeting drug addictions – A translational perspective (S17-S20) SYMPOSIUM 6 A7 Functional imaging markers for monitoring treatment: Mechanisms and efficacy (S21-S24) SYMPOSIUM 7 A9 Schizophrenia Treatment: What’s wrong with it and what might work better (S25-S28) SYMPOSIUM 8 A10 Epigenetics and psychiatry - current understanding and therapeutic potential (S29-S32) SYMPOSIUM 9 A11 Rethinking the compulsive aspects of addiction: From bench to bedside (S33-S36) POSTERS Anxiety 1 (MA01-MA07) A13 Affective Disorders 1 (MB01-MB20) A16 Brain Imaging
    [Show full text]
  • Research Chemicals Und Andere Neue Drogen
    Research Chemicals & andere „neue“ Drogen Impulsreferat auf der DO-Leitertagung am 08.04.2014 Dipl.-Psych. Marcus Breuer psycholog. Psychotherapeut Begriffsklärung • Crystal = Crystal Speed; kristallines Metamphetamin • ATS = Amphetamin Type Stimulants • NPS = New Psychoactive Substances • Badesalze = Szenebezeichnung, denkbar ungeeignet, weil sie nichts erklärt und außerdem verharmlost • Research Chemicals = diese Stoffe sind „Abfallprodukte“ aus der Medikamentenentwicklung oder aber gezielte Veränderungen bekannter psychoaktiver Substanzen • Legal Highs = viele dieser neuen Stoffe sind bzw. waren zunächst legal (nicht dem BtmG unterstellt) • Kräutermischungen = Spice & Co., rauchbare synthetische Cannabinoide (viel toxischer als Cannabis) Wirkbogen der Partydrogen Entaktogene Ecstasy-MDMA MDEE Häufigkeit • ATS= Amphetamine Type Stimulants • Amphetamin (Speed) • XTC (MDMA; MDE; MDA) • Methamphetamin (Crystal) • Weltweit zusammen 26 million “regular users” vs: • Kokain 14 million reg. users • Heroin 16 million reg. users Nach WHO and UNODOC-Schätzungen (2010) ist Methamphetamin weltweit alleine die nach CANNABIS am häufigsten konsumierte illegale Substanz(18 Mio) (Nikotin und Alkohol sind Hauptproblem…..) Gesamtzahlen erstauffällige Konsumenten nach BKA: Trend 2000-2009 Drogentrends Exkurs: Research Chemicals I Neue Clubdrugs/Trenddrogen - fast alles RC-Drugs: • Substanzen, die zu Forschungszwecken genutzt werden und als solche „gekauft“ werden…. • RC-Substanzen (research chemicals) / Designerdrugs….. • Zeitweise nicht dem BTMG der jeweiligen
    [Show full text]
  • From Religious Ecstasy to Ecstasy Pills: a Symbolic and Performative Analysis of Electronic Music Festivals
    Relig. Soc. vol.2 no.se Rio de Janeiro 2006 From religious ecstasy to ecstasy pills: a symbolic and performative analysis of electronic music festivals Tiago Coutinho ABSTRACT This article looks to analyze the process through which eastern cosmological elements and religious practices acquire new meanings as they take on fresh uses in western festive contexts, as well as examine the symbolic and performative dimensions of the phenomenon in question. Electronic music festivals suggest a reading of eastern religious factors that serve as a reference to their ‘origin myth.’ The ethnographic data reveals a new form of obtaining ecstasy via music, performances, ‘natural’ ambients and altered states of consciousness. The appeal to transcendence is the direct result of western re-workings of Indian religious practices – especially those proposed by the spiritual leader Osho, who formed a cosmology based on fragments taken out of their ‘original’ context and given meaning in the life of those who adopt the Sannyasa lifestyle. Keywords: party, performance, psychoactive drugs, New Age spirituality Introduction Based on the ethnographic material contained in my master’s dissertation, this article explores a movement of resignification that transplants fragments of eastern religious systems to the festival contexts of young westerners. It looks to highlight the symbolic and performative dimensions of this phenomenon and its particular appeal to transcendence. The specific type of electronic music festival under study exemplifies the transposition from eastern practices to western capitalist contexts via facts and events occurring over the last thirty years that rework the meanings of one of the most important youth countercultures of the 20th century, the hippie movement.
    [Show full text]
  • Biosynthetic Production and Structural Studies of Glycolipids and Large Fragments of G-Protein Coupled Receptors
    Zurich Open Repository and Archive University of Zurich Main Library Strickhofstrasse 39 CH-8057 Zurich www.zora.uzh.ch Year: 2010 Biosynthetic production and structural studies of glycolipids and large fragments of G-protein coupled receptors Kumaran, Sowmini Posted at the Zurich Open Repository and Archive, University of Zurich ZORA URL: https://doi.org/10.5167/uzh-42491 Dissertation Published Version Originally published at: Kumaran, Sowmini. Biosynthetic production and structural studies of glycolipids and large fragments of G-protein coupled receptors. 2010, University of Zurich, Faculty of Science. !" !"&'()'"'()* +,'$" #+0&.+1'*,'$/-02(.$/.")$( 0(12%' /"2".$+0&.( 30-7)+8-079)&'!( 0(172* $)"&(8 ,2/).(9)*)5' *!! :"$$)-$0'" # ;,- ?-20&4,&7(.)-(&0',-="$$)&$'(03$2"*()&(: >$ *=B-.) A:-D($'D(&0'DE D *7)2)4$(.)- E0'()90$"$'(7&0',-="$$)&$'(03$2"*()&(80A,2'F$ .)- I&"F)-$"$F$(HB-"'( D # " !%&'&!()%'('$ 0/$ ,'-&.$! ((((((,- 6 $" #$A 9"$)) ,( -.!2(.!04&5.(!3.(7.!89 (7#89!)'-!:.#8&$;!-.(!2&77.(8'8# $< !,( -.!2(.!= >$!B 4#$7 $ HB-"'(I(LMNM Table of Contents Abbreviation 1 Summary 5 Zusamenfassung 8 Chapter 1 11 1.0 Introduction 11 1.1 Chemistry of protein–carbohydrate interactions 12 1.1.1 Hydrogen bonds 13 1.1.2 Hydrophobic interactions 13 1.1.3 Electrostatic interactions 13 1.1.4 Role of water 14 1.2 Tools for analyzing carbohydrate protein interactions 14 1.2.1 NMR approaches to study carbohydrate–protein Interactions 14 1.2.2 NMR parameters that yield information on protein ligand interactions physiological functions of Y receptors 16 1.2.2.1 Chemical shift 16 1.2.2.2 Relaxation parameters 16 1.2.2.3.
    [Show full text]