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Pharmacology Notebook 1 PDF (Searchable) The Shulgin Lab Books December 2012 May 2018 Pharmacology Lab Notes #1 (1960 - 1976) A Bit About This Document: While undertaking the work of investigating the chemistry and pharmacology of many varied psychoactive substances, Alexander “Sasha” Shulgin kept detailed notebooks. His documentation covered not only on his own personal research, but the research of friends and acquaintances. This book, the first of the “Pharmacology” series, represents mostly sub-acute work-ups of various substances and subjective responses by Shulgin and his research group. It covers the time frame of 1960 to 1976. The Creation of This Document: The project to undertake the transcribing of Shulgin’s Lab Books was started in 2008 by a team of volunteers and staff at Erowid, along with members of Team Shulgin. Various books were transcribed without a clear idea of how to present the information as a final product; eventually this format was chosen and a volunteer began work assembling the document. Each page was painstakingly transcribed from scanned images. All the hand-drawn “dirty pictures” (molecule drawings) and graphs were edited from the original scans and combined with drawn-in marks, outlines, and arrows to form this searchable PDF. Most of the names in this document have been redacted and pseudonyms put in their place. Names are presented as much as possible as they were in the original book, for example “Robert Thompson” is also “Robert”, “R.Thompson”, and “RT”. Initials are frequently used, and no two people share names or initials so the reader can keep track of who’s who. Words highlighted in yellow are words that the transcription team could not decipher. If you think you can help us decipher some of these words, please contact [email protected]; we would love your help. This document is intended to resemble the look and feel of the original lab book as much as possible; minor corrections and clarifications have been made to make things easier to read, and to better fit this format. Words created specifically by Shulgin remain as found, for example: “Tooth-rubby” to describe bruxism. Shulgin uses some shorthand throughout this book; the only shorthand we have made an effort to clarify is the use of the letter “c” with a dash above it (from the Latin word cum, meaning “with”), which had been replaced by “[with]”. Other common shorthand to note: ∴ is “therefore”, ≅ is “approx. equal to”, ≡ is “identical to”, and ≎ is “equivalent to”. Bold text represents typewritten documents that were pasted into the lab book by Shulgin, and bold italic text represents handwritten documents pasted into the book that are not in Shulgin’s handwriting. All other text is Alexander Shulgin’s. Credits: Erowid Project Lead: Shawn Corrado Transcription Team: Jick Magger, Kaw71, Kernel, Lizardphunk, Bananaskin, Shawn Corrado, Henryaj Image Editing/Redacting/PDF Assembly: Shawn Corrado Team Shulgin: Sasha & Ann, Paul Daley, Tania & Greg Manning Erowid: Earth, Fire, Spoon To cite this document: Shulgin A. "Pharmacology Notes 1: 1960-1976". Erowid's Shulgin Archiving Project. Published 2012. URL: https://erowid.org/library/books_online/shulgin_labbooks/shulgin_labbook1_searchable.pdf The original version of this document and supporting files can be found here: http://www.erowid.org/library/books_online/shulgin_labbooks/ For any questions or comments please contact [email protected] Projects like this one are made possible by your continued support, please visit Erowid.org/donations Notebook closed, July, 1979 Property of A.T. Shulgin Notebook copied August 1979 1483 Shulgin Rd Lafayette. Calif. 94549 (415) 934.4930 reward for return ADDRESSES TO KEEP Andrew French DEPT. OF ANTHROPOLOGICAL MEDICINE INSTITUTE OF PERSONALITY ASSESSMENT ESCUELA DE MEDICINA AND RESEARCHES UNIV. OF CHILE 2240 PIEDMONT AVE SANTIAGO BERKELEY. Robert Thompson 1044 SILER PLACE BERKELEY S CALIF. Martin Brady INSTITUTE OF SOCIAL & PERSONAL RELATIONS· 215 VALLEY VIEW DRIVE 2903 TELEGRAPH AVE. PETALUMA BERKELEY Henry Brock Dept. of MENTAL HYGIENE INSTITUTE OF MEDICAL SCIENCES. 3330 Geary Blvd. SF EYE RESEARCH INSTITUTE 2200 Webster. SF Common Names within Groups and Potency IN mescaline units ( ) Homologues: MESCALINE (1.0) TMA (2.2) AEM Cyclics: MMDA (2.7) MEDA MTDA Isomers: MMDA TMA (2.7) (2.2) MMDA-2 TMA-2 MMDA-3a TMA-3 MMDA-3b MMDA-4 TMA-4 MMDA-5 TMA-5 TMA-6 MESCALINE SUBJECTIVE RESPONSE 7 1-7 BASIS FOR M.U. CALCULATION 7 TMA SUB-ACUTE EVALUATION 8 OBJECTIVE RESPONSES 9 SUBJECTIVE RESPONSE 227,13 AEM SUB-ACUTE EVALUATION 20 MMDA SUB-ACUTE EVALUATION 21,104 SUBJECTIVE RESPONSES 22 OBJECTIVE RESPONSES 23,24,28 90,91,105, 113.114,116 118 119-20 117,122,123 123 MEDA SUBACUTE EVALUATION 35 MTDA SUBACUTE EVALUATION 36 MDA (METHYLENEDIOXYAMPHETAMINE) SUBACUTE EVALUATION 37, 123, +SUBJECTIVE +OBJECTIVE 202, 203 234 246 NACM (N-ACETYL MESCALINE) SUBACUTE EVALUATION 38 halo – 2,4,5 halo – 3,4,5 4-BR – 152,226 4-Br 197 4-Cl – 162 DMMMDA-2 – 140 < 4-Br isomers – 117 4-Br (2-carbon)-172,204,211 4-I – 173 ALKOXY – 3,4,5 4-I (4·carbon)-174 4-I (2 carbon)-179 4-OPr 209 (2 carbon) 4-OET 217 (2 carbon) 4-OCH2Φ 48 (3 carbon) 4-OCH2ΦF 145 (3 carbon). 4-OET 222 (3 carbon) 4-OBu (2 carbon) MAM - 87 MBM - 86 MPM - 82 - 257 3-way study 151,185,224 ≡ MMM (TMA-2) (page 54,55,64,) EMM (see 5-1502)-(page 60) MME - 77 ALEPH FAMILY. EME 3-way study #2 5-Et – 194-205-220 #4 5-isopropyl 219 MEM -78,80,112,151,229 #6 5-Φ 221 260 #7 5-propyl 223 EEM META-DOT MEE -79 ORTHO-DOT EEE <-PARA-DOT hor-oxy 4-TMA 2 > 84,88,92,101,102-103 106 (optical isomers, 165) 212 (2-carbon, 175)(273) 4-DOM 216 4-DOE -> 95;110,111,213 (2-carbon, 236) 206 N-Ethyl-MDA MDE 4-DOP - 115;124,132 N-Methoxy MDA 248 237 MDIP 4-DOBU 167 N-Methoxy- IRIS 166 ehtyl MDA 250 249 MDDM 4-DOBT->100 4-DOAM 170 245 methoxyethyl MDA DMMA SUBACUTE EVALUATION 39 SUBJECTIVE RESPONSES 4,41 DMMA-2 (2,3-Dimethoxy-4,5-methelenedioxy Amphetamine 140 S-1495 SUBACUTE EVALUATION 44 SUBJECTIVE RESPONSES 47 STEREO-ASSIGNMENTS 46 S-1496 SUBACUTE EVALUATION 45 4-THIO-MMDA-2 240 4-THIOMESCALINE 239 LSD 269 214,247 TMA-2 SUBACUTE EVALUATION 54 ETHANOL p.157 SUBJECTIVE RESPONSES <- 55,66 108,151 N-METHYL-4-BROMO-2,5-DMA. p.208 183,224 HYDROXY- DOP 198 TMA-3 SUBACUTE EVALUATION 85 5-SCH3-2,4-DIMETHOXYAMPHETAMINE 182 2-SCH3-4,5-DIMETHOXYAMPHETAMINE 181 4-SCH3-2,5-DIMETHOXYAMPHETAMINE 178,200 TMA-4 SUBACUTE EVALUATION 61 Z-7 166-190 GANESHA 224 183 other N-Me'S of R 230 235 241 242 N-METHYL-MDA (MDMA) G.anderson 186 S 231 232,210,186,207 5-ETHOXY-2-METHOXY-4-METHYLAMPHETAMINE 180 SATURATION EXPERIMENTS MEM-MDMA 233 Meth-MDMA 234 WINDOW EXPLOITATION 247,249,256 (F-310) 5-DOM > MMDA 2-1 (2-methoxy 4,5- Methylenedioxy Phenethylamine 75 MMDA 2+1 1-(2-methoxy-4,5-Methylenedioxyphenyl)-2 aminobutane 76 MMDA 3-1 (2-methoxy 3,4- Methylenedioxy Phenethylamine 73 MMDA 3+1 1-(2-methoxy-3,4-Methylenephenyl)-2 aminobutane 74 4 BR > TMA-5 SUBACUTE EVACUATION 97 5-Methyl-2,4-dimethoxyamphetamine 169 6-HYDROXY-3,4-DIMETHOXYPHENETHANOLAMINE 168 2,6-DIMETHOXY-4-METHYLAMPHETAMINE (Z-7) 166,190 TMA-6 <- SUBACUTE EVALUATION 93 253,188 N-MeDOM p-164 SUBJECTIVE RESPONSES 150,98, F-2,2 163 4-Cl(PCL) 162 MMDA-2 <- SUBACUTE EVALUATION 49,215 l(-)-TMA-2 p-161 SUBJECTIVE RESPONSES 50,51,83 d(+)-TMA-2 p-160 109, 215 192 ARIADNE 159 – 193 MMDA-3a SUBACUTE EVALUATION 281,62 SUBJECTIVE RESPONSES 66,88 TMT 158 4-Cl PEA. 157 2-M 156 MMDA-3b SUBACUTE EVALUATION 150 DME 155 Asarone 154 ARMALINE 7(Methoxyharmalan)- 153,225 MMDA-4 SUBACUTE EVALUATION 4BR 226 152 β-OH-MDA MDE 149 Berberine 148 Hystradine + a multitude of misc *** 147 Methoxy Eugenol. 138 Carbolines 146 < 147 < tetrahydro harmine -> 128 Harmaline -> 153,225 "Tetrahydo norharman" -> 128 DMA EMM α-methyl tryptamines Other tryptamines (N,N-R)(α-hydrogen) α-methyl 35135 5-OCH3 DIPT 176,191,218 α-methyl-5-methoxy 184 DIPT 177 196 252 DMT 137 PSILOCYBIN 187 N-tbutyl 191 N,N-Me, Et 191 N,N-Me, IsoPropyl 191 5-OCH3 DMT 195,194 4-Hydroxy-N,N-dialkyl T. 191 more from others- 191 < MMDA- 5 SUBACUTE EVALUATION 166 6-METHOXYHARMALAN 146 6-METHOXYTETRAHYDROHARMAN 147 4-FLUOROBENZYLOXYDIMETHOXY AMPHETAMINE 145 BENZYLOXYDIMETHOXY AMPHETAMINE; SUBACUTE EVALUATION 48 2,4-DMA (2,4-DIMETHOYAMPHETAMINE) 144 DMA (3,4-DMA) (3,4-DIMETHOXYAMPHETAMINE) 143 2,5-DMA (2,5-DIMTHOXYAMPHETAMINE) SUBACUTE EVALUATION 57 SUBACUTE RESPONSE 58 N-Me Mescaline 142 N-Me TMA- SUBACUTE EVALUATION 59 MA 4-methylene Methoxyamphetamine 141 Pseunut Coctail 139 (2- Ethoxy-4,5- S-1502 DIMETHOXYAMPHETAMINE) SUBACUTE EVALUATION 60 -<DMT. Dimethyltryptamine 137 Ibogaine. 136 S.DIVINORUM SUBACUTE EVALUATION 63,96 2,5-DIMETHOXY-4-METHYLPHENYETHYL AMINE (DOM-2 carbon) 94 α-Methyl Tryptamine. 135 search, SAR - as of the moment. 6/17/63 > 72 3,4-DIMETHOXYPHENETHYLAMINE 107 2,3,4,5-TETRAMETHOXYAMPHETAMINE 125 Lophophine (3-methoxy-4,5-methylenediocyphenethylamine) 127,228 Tetrahydroharmine 128 Dextro-amphetamine 133 DL. N-Methylamphetamine. also D-N-methylamphetamine 134 1 Subjective response to Mescaline. 4/18/60 Date 4/16/60 Subject ATS. Observer MW. DOSE 0.400 g mescaline sulfate in water - preceded by 0.050 g marezine one hour earlier. Slight bitter taste - not unpleasant. CHRONOLOGY After 0.5 hrs. noticeable intoxication - 0.7 hrs first nausea successfully combated - at 1.3 hrs end of nausea - comfortable - slight speech difficulty - 1.5 hrs.
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