journal of Analytical Toxicology 2015;39:617-623 doi,10.1093/jar/bkv073 Special Issue Analysis of 251-NBOMe, 25B-NBOMe, 25C~NBOMe and Other Dimethoxyphenyl-N-[(2-Methoxyphenyl) Methyl]Ethanamine Derivatives on Blotter Paper Justin L. Poklisl, Stephen A.Raso-, Kylie N. Alford", Alphonse Poklis1.2,3 and Michelle R. Peace?" 'Department of Pharmacology and Toxicology, Virginia Commonwealth University, Richmond, VA,USA,zDepartment of Forensic Science, Virginia Commonwealth University, PO Box 843079,1015 Floyd Avenue, Room 2015, Richmond 23284, VA,USA,and 3Department of Pathology, Virginia Commonwealth University, Richmond, VA,USA •Authorto whom correspondence should be addressed.Email:
[email protected] In recent years, N-methoxybenzyl-methoxyphenylethylamine (NBOMe) methoxybenzyl)ethanamine (25E-NBOMe), 2-(2,5-dimethoxy- derivatives, a class of designer hallucinogenic drugs, have become 3,4 dimethylphenyl)-1V-(2-methoxybenzyl)ethanamine (25G- popular drugs of abuse. These drugs have been the cause of severe l\'BOMe), N(2-methoxybenzyl)-2,5·dimethoxy-4-chlorophene- intoxications and even deaths. They act as S-HT2A receptors agonists thylamine (25C-NBOMe) and 2-(4-iodo-2,5-dirnethoxyphenyl)- and have been reported to produce serotonin-like syndrome with bi- N[(2,3-methylenedioxyphenyl) methyl]ethanamine (25I-l\TBMD) zarre behavior, severe agitation and seizures persisting for as long (9-i 1). as 3 days. The most commonly reported derivatives are 2SI-NBOMe, Several publisbed abstracts and clinical case reports have de- 2SB-NBOMe and 2SC-NBOMe, respectively 2-(4-iodo-2,S-dimethoxy- scribed signs and symptoms of 25I-NBOMe (1, s, 12-1(;), phenyl)-N-[(2-methoxyphenyl) methyljethanamine, N-(2-methoxyben- 25B-l\'BOMe (17-20) and 25C-NBOMe (W-Zl) intoxication.