Virginia Commonwealth University VCU Scholars Compass Theses and Dissertations Graduate School 1983 Distribution of Imipramine, Desipramine and Their Principal Metabolites Between Plasma, Red Blood Cells and Brain in Humans and Animal Models Stuart Chapman Bogema Jr. Follow this and additional works at: https://scholarscompass.vcu.edu/etd Part of the Medicine and Health Sciences Commons © The Author Downloaded from https://scholarscompass.vcu.edu/etd/4357 This Dissertation is brought to you for free and open access by the Graduate School at VCU Scholars Compass. It has been accepted for inclusion in Theses and Dissertations by an authorized administrator of VCU Scholars Compass. For more information, please contact
[email protected]. DISTRIBUTION OF IMIPRAMINE, DESIPRAMINE AND THEIR PRINCIPAL METABOLITES BETWEEN PLASMA, RED BLOOD CELLS AND BRAIN IN HUMANS AND ANIMAL MODELS A dissertation submitted in partial fulfillment of the requirements for the degree of Doctor of Philosophy at Virginia Commonwealth University by Stuart Chapman Bogema, Jr. B.S. University of Richmond Richmond, VA, 1974 Directors Robert V. Blanke, Ph.D. Professor, Departments of Pathology and Pharmacology and Toxicology Nedathur Narasimhachari, Ph.D. Professor, Departments of Psychiatry and Pharmacology and Toxicology Virginia Commonwealth University Richmond, Virginia August 1983 .This dissertation by STUART CHAPMAN BOGEMA, JR is accepted in its present form as satisfying the thesis requirement for the degree of Doctor of Philosophy. Date.:., . [!!I' 0 '-1<7. -/'<-..-- Ill,? C ---r------:,-- I />/f.; ;J lvfl.;- �- J.?.1� <J.),.,;/_ f4-f -:; -�-· - f1_('if.$ . (l,'!-5z: '!!:C/ :; -�--�-!.tF:!. APPROVED: . · -·-·-··· Sciences A C K N O W L E D G E M E N T S Most of all, I would like to thank my wife, Connie, for her patience and perserverance during the last four years.