DOCSLIB.ORG

Monoclonal Antibodies to Migraine: Witnesses to Modern Biomedicine, an A-Z Tansey, EM; Jones, EM

Total Page：16

File Type：pdf, Size：1020Kb

Download full-text PDF Read full-text
Monoclonal Antibodies to Migraine: Witnesses to Modern Biomedicine, an A-Z Tansey, EM; Jones, EM Monoclonal Antibodies to Migraine: Witnesses to modern biomedicine, an A-Z Tansey, EM; Jones, EM For additional information about this publication click this link. http://www.histmodbiomed.org/sites/default/files/W50_LoRes.pdf Information about this research object was correct at the time of download; we occasionally make corrections to records, please therefore check the published record when citing. For more information contact [email protected] WITNESSES TO MODERN BIOMEDICINE, AN A–Z Edited by E M Jones and E M Tansey Volume 50 2014 ©The Trustee of the Wellcome Trust, London, 2014 First published by Queen Mary, University of London, 2014 The History of Modern Biomedicine Research Group is funded by the Wellcome Trust, which is a registered charity, no. 210183. ISBN 978 0 90223 895 4 All volumes are freely available online at www.history.qmul.ac.uk/research/modbiomed/ wellcome_witnesses/ Please cite as: Jones E M, Tansey E M. (eds) (2014) Monoclonal Antibodies to Migraine: Witnesses to Modern Biomedicine, an A–Z. Wellcome Witnesses to Contemporary Medicine, vol. 50. London: Queen Mary, University of London. CONTENTS Acknowledgements E M Tansey and E M Jones v Foreword Sir Mark Walport vii Introduction E M Tansey ix Titles of Witness Seminar volumes xvii Dramatis personae xxi Abbreviations xxxvii Monoclonal Antibodies to Migraine: Witnesses to Modern Biomedicine, an A–Z 1 Index 185 Illustration credits 215 Witness Seminars: Meetings and publications 218 iii This volume is dedicated to Dr Peter Williams CBE (1925–2014), first Director of the Wellcome Trust, 1965 to 1991. ACKNOWLEDGEMENTS Extracts from the Witness Seminar volumes have been suggested by many people in addition to the editors. In particular, we would like to thank Dr Julie Hartley, Ms Caroline Overy, Dr Tom Quick, Mrs Lois Reynolds, Mr Adam Wilkinson and Mr Alan Yabsley for their input. Additionally, Dr John Ford, Professor David Gordon, Professor Richard Himsworth and Mrs Lois Reynolds have advised and commented on the final selection. This volume would also not have been possible without the work of the former members of the History of Modern Biomedicine Group over some twenty- one years: Professor Sir Christopher Booth (co-founder, with Tilli Tansey); Dr Daphne Christie; Ms Stephania Crowther; Mrs Wendy Kutner and Ms Sonia Willhoft. For the photographic portraits, we are most grateful to the Wellcome Trust’s photographers over the years, and to the staff at Wellcome Images. We also thank the contributors who have provided additional illustrative material for our volumes. Thanks are also due to Mr Akio Morishima for the design of this volume; the indexer Ms Liza Furnival; and Mrs Sarah Beanland and Ms Fiona Plowman for proof reading. As ever, we are most grateful to the Wellcome Trust for financially supporting this programme. The first Director of the Wellcome Trust, Dr Peter Williams, was closely associated with the creation of the History of Modern Biomedicine Research Group, and attended and contributed to several early Witness Seminars. Sir Mark Walport, Director 2003 to 2013, was equally enthusiastic and often contributed directly, as his generous foreword makes clear. Finally, we thank all those who have participated in our meetings over the years, whether or not their words are included in this volume. Tilli Tansey Emma M Jones School of History, Queen Mary, University of London v FOREWORD Governments around the world obsess about how they can ensure that basic research is turned into human benefit. And governments do what governments can do, which is to provide catalysis through funding, tax breaks and a policy environment that facilitates rather than hinders innovation. But if you really want to discover how to innovate, read this volume, published in the 21st anniversary year of the first Witness Seminar on monoclonal antibodies. This is a master class on how to innovate in medicine. It is people who innovate and it is the people who scintillate in this extraordinary anthology. Their values and personalities come to the fore: humane, free-thinking, always wanting to try new things, to innovate. Their personality traits are also apparent, a cast of individualists and eccentrics, stubborn and cussedly single-minded, accompanied by a strong common denominator of caring and humane compassion. The vignette on cystic fibrosis reminded me of six months as John Batten’s SHO in the adult cystic fibrosis unit at the Brompton – an extraordinary clinician leading an equally extraordinary team. The Witness Seminar on cystic fibrosis reminds us that the substantially increased survival of people with cystic fibrosis is due to the dedication of John Batten and his counterparts around the world. The innate curiosity of clinical scientists shines through the vignettes; being both clinician scientist and naturalist is a common association, for example Cyril Clarke, Estlin Waters and Christopher Andrewes. This volume also acts as a reminder of what it means to be professional – to be scholarly and rigorous in rooting out and applying evidence, to apply judgement in clinical decision making, to be prepared to innovate, and to be responsible and accountable for decisions. I was transported in an instant to the Royal Postgraduate Medical School of my youth – and to many of the characters who passed through its doors. It also reminds us how values, ethics and innovation are intertwined. There are examples from intensive care and leukaemia and from the deliberations of the London Medical Group and from innovators in public health and population studies. I have always enjoyed the Witness Seminars – the witnesses are alive and their recollections vivid. They are always entertaining, not least because the participants sometimes disagree or have different recollections of the same events! Like all the best anthologies, this is full of gripping vignettes and stories. It should be read by all inquisitive doctors, which should give it a large circulation, since all doctors should be inquisitive. Sir Mark Walport, Government Chief Scientific Adviser, UK vii INTRODUCTION* Dr Georges Köhler, Sir Christopher Booth, Dr César Milstein (left to right) at the first Witness Seminar on Monoclonal Antibodies, 1993 In September 1993 the Wellcome Trust’s History of 20th Twentieth Century Medicine Group held its first Witness Seminar on the topic of monoclonal antibodies, for which the main witnesses, César Milstein and Georges Köhler, had shared the 1984 Nobel Prize in Physiology or Medicine. Our intention was to use the occasion to examine the events behind the headlines and accolades; to explore what did or didn’t happen; identify who were the influential players (not always synonymous with the best-known names); and to hear the voices and perspectives of a wide group of people who were ‘there at the time’ in different capacities. The success of that meeting, as assessed by the frankness of the participants on the day and their ready and enthusiastic engagement with the subsequent editorial and archival processes, compounded by several requests for copies of the edited transcript, encouraged us to develop a modest programme of four further meetings to record and reflect on recent biomedical history. Fast forward 21 years and we have now organized in excess of 60 Witness Seminars attended by more than 1400 people, and have advised several other groups and individuals on developing similar programmes. We have edited and published 58 transcripts of those meetings, most, but not all, in the freely * Page numbers refer to this volume; volume titles refer to the published Witness Seminars (see pages xvii–xx, 218–21 for full lists) ix available series now entitled ‘Wellcome Witnesses to Contemporary Medicine’. The 49th volume in that series, Migraine: Diagnosis, treatment and understanding c.1960–2010, appeared recently. Some volume titles may seem obscure, even off-putting, to the non-specialist reader. For example, The Discovery, Use and Impact of Platinum Salts as Chemotherapy Agents for Cancer and Population-based Research in South Wales: The MRC Pneumoconiosis Research Unit and the MRC Epidemiology Unit do not immediately suggest the range and depth of human interest stories they actually contain. Thus, as we approached our 50th volume we decided to collect together edited ‘highlights’ taken from all the volumes, to illustrate the diversity and richness of many individual experiences of, and contributions to, recent biomedicine. The main objective of the Witness Seminar programme has always been to hear and record the authentic voices of our contributors; for this anniversary volume we want to introduce some of those less well-known voices to fresh audiences. Selection and editing Several people listed in the acknowledgements were involved in selecting suitable extracts. Some selectors read only one or two volumes; others read rather more; and between us the two editors have read, or re-read, all the volumes. There were no restrictive criteria – all were invited to select extracts that intrigued or amused them; that seemed representative of a theme, specialty, or period; or conversely, something that was unique. Consequently, these stories and snippets vary widely – some quirky, some moving, some amusing, some thought-provoking. We have not imposed a word length – some are short and pithy, one or two are rather more expansive. Our first selection of extracts was over 500 pages long, and we have gradually refined, reduced, and edited our choices to produce a more manageable volume. For each extract, repetitions and discursive material have been removed, and sometimes sentences have been run together from adjacent paragraphs or pages to provide a continuous narrative. Dates or other explanatory material have been added where appropriate. Strictly speaking therefore, few of these extracts are verbatim quotes, and in the interests of readability we have intentionally avoided the large-scale use of ellipses, parentheses, and footnotes to identify our editorial work. For those who do want to read the unexpurgated text, each extract is carefully referenced to the original publication.
Load more

Recommended publications
  • NATIONAL LIFE STORIES CITY LIVES Sir Roger Gibbs Interviewed
    NATIONAL LIFE STORIES CITY LIVES Sir Roger Gibbs Interviewed by Cathy Courtney C409/086 This interview and transcript is accessible via http://sounds.bl.uk. © The British Library Board. Please refer to the Oral History curators at the British Library prior to any publication or broadcast from this document. Oral History The British Library 96 Euston Road London NW1 2DB United Kingdom +44 (0)20 7412 7404 [email protected] Every effort is made to ensure the accuracy of this transcript, however no transcript is an exact translation of the spoken word, and this document is intended to be a guide to the original recording, not replace it. Should you find any errors please inform the Oral History curators. THE NATIONAL LIFE STORY COLLECTION NTERVIEW SUMMARY SHEET Title Page ____________________________________________________________________ Ref. No.: C409/86 Playback No.: F3119-F3127; F5223-F5226; F9681-F9683; F12013-F12016 ____________________________________________________________________ Collection title: City Lives ____________________________________________________________________ Interviewee’s surname: Gibbs Title: Sir Interviewee’s forenames: Roger Date of birth: 13th October 1934 Sex: Male ____________________________________________________________________ Date(s) of recording: 21.01.1992; 04.11.1992; 03.02.1993; 20.04.1993; 15.11.1995; 19.04.2001; 11.10.2002 Location of interview: Interviewee’s home and British Library Name of interviewer: Cathy Courtney Type of recorder: Marantz Total no. of tapes: 20 (interview incomplete) Type of tape: Mono or stereo: Speed: Noise reduction: Original or copy: ____________________________________________________________________ Additional material: ____________________________________________________________________ Copyright/Clearance: © British Library ____________________________________________________________________ Interviewer’s comments: Re Tapes 17-20 (F12013-F12016). I had an arrangement to go for two hours and in fact recorded for four hours.
    [Show full text]
  • HUMAN GENE MAPPING WORKSHOPS C.1973–C.1991
    HUMAN GENE MAPPING WORKSHOPS c.1973–c.1991 The transcript of a Witness Seminar held by the History of Modern Biomedicine Research Group, Queen Mary University of London, on 25 March 2014 Edited by E M Jones and E M Tansey Volume 54 2015 ©The Trustee of the Wellcome Trust, London, 2015 First published by Queen Mary University of London, 2015 The History of Modern Biomedicine Research Group is funded by the Wellcome Trust, which is a registered charity, no. 210183. ISBN 978 1 91019 5031 All volumes are freely available online at www.histmodbiomed.org Please cite as: Jones E M, Tansey E M. (eds) (2015) Human Gene Mapping Workshops c.1973–c.1991. Wellcome Witnesses to Contemporary Medicine, vol. 54. London: Queen Mary University of London. CONTENTS What is a Witness Seminar? v Acknowledgements E M Tansey and E M Jones vii Illustrations and credits ix Abbreviations and ancillary guides xi Introduction Professor Peter Goodfellow xiii Transcript Edited by E M Jones and E M Tansey 1 Appendix 1 Photographs of participants at HGM1, Yale; ‘New Haven Conference 1973: First International Workshop on Human Gene Mapping’ 90 Appendix 2 Photograph of (EMBO) workshop on ‘Cell Hybridization and Somatic Cell Genetics’, 1973 96 Biographical notes 99 References 109 Index 129 Witness Seminars: Meetings and publications 141 WHAT IS A WITNESS SEMINAR? The Witness Seminar is a specialized form of oral history, where several individuals associated with a particular set of circumstances or events are invited to meet together to discuss, debate, and agree or disagree about their memories. The meeting is recorded, transcribed, and edited for publication.
    [Show full text]
  • Genetic Testing
    GENETIC TESTING The transcript of a Witness Seminar held by the Wellcome Trust Centre for the History of Medicine at UCL, London, on 13 July 2001 Edited by D A Christie and E M Tansey Volume 17 2003 CONTENTS Illustrations v Introduction Professor Peter Harper vii Acknowledgements ix Witness Seminars: Meetings and publications xi E M Tansey and D A Christie Transcript Edited by D A Christie and E M Tansey 1 References 73 Biographical notes 91 Glossary 105 Index 115 ILLUSTRATIONS Figure 1 Triploid cells in a human embryo, 1961. 20 Figure 2 The use of FISH with DNA probes from the X and Y chromosomes to sex human embryos. 62 v vi INTRODUCTION Genetic testing is now such a widespread and important part of medicine that it is hard to realize that it has almost all emerged during the past 30 years, with most of the key workers responsible for the discoveries and development of the field still living and active. This alone makes it a suitable subject for a Witness Seminar but there are others that increase its value, notably the fact that a high proportion of the critical advances took place in the UK; not just the basic scientific research, but also the initial applications in clinical practice, particularly those involving inherited disorders. To see these topics discussed by the people who were actually involved in their creation makes fascinating reading; for myself it is tinged with regret at having been unable to attend and contribute to the seminar, but with some compensation from being able to look at the contributions more objectively than can a participant.
    [Show full text]
  • BWF History Book 2
    HISTORY of the BURROUGHS WELLCOME FUND 1955-2005 Celebrating 50 Years of Advancing the Biomedical Sciences HISTORY of the BURROUGHS WELLCOME FUND 1955-2005 Project Coordinator and Editor: Mirinda J. Kossoff Contributing Writers: Tom Burroughs Anastasia Toufexis Book Design: Generate Design ®2005 Historic Preservation Foundation of North Carolina, Inc. All rights reserved. ISBN Number: 0-9673037-0-1 Table of Contents FOREWORD . .1 CHAPTER ONE Sir Henry Wellcome’s Legacy . .4 CHAPTER TWO In the Beginning . .20 CHAPTER THREE Bigger and Better . .32 CHAPTER FOUR Fulfilling the Promise . .46 CHAPTER FIVE Burroughs Wellcome Fund Today . .56 CHAPTER SIX Behind the Scenes . .80 AFTERWORD . .88 BOARD AND STAFF 1955 - 2005 . .90 1955 BWF established as a corporate foundation in Tuckahoe, New York FOREWORD 1955 William N. Creasy appointed first president and board chair 1959 First advisory committee appointed, The Burroughs Wellcome Fund, or BWF as it has become on clinical pharmacology known, is now 50 years old. During the past half century, 1959 First competitive award program launched—Clinical Pharmacology BWF has transformed itself from a small corporate foundation, Scholar Awards 1970 BWF moves to Research Triangle with assets of $160,000 and awards totaling $5,800 in 1955, Park, North Carolina (with Burroughs Wellcome Co.) to a major independent private foundation, with assets in 1971 Dr. George H. Hitchings excess of $650 million and annual awards of more than becomes president $25 million in 2005. In the past decade alone, BWF has made 1974 Iris B. Evans appointed first executive director approximately $250 million in grants. 1978 BWF grantmaking reaches $1 million annually 1979 Toxicology Scholar Awards Through strong, farsighted leadership over the years, program launched BWF has played a significant role in the biomedical sciences 1981 Martha Peck appointed executive director by supporting research and education.
    [Show full text]
  • Genetic Testing (V19) 3/11/03 8:46 Pm Page I
    Genetic Testing (v19) 3/11/03 8:46 pm Page i GENETIC TESTING The transcript of a Witness Seminar held by the Wellcome Trust Centre for the History of Medicine at UCL, London, on 13 July 2001 Edited by D A Christie and E M Tansey Volume 17 2003 ©The Trustee of the Wellcome Trust, London, 2003 First published by the Wellcome Trust Centre for the History of Medicine at UCL, 2003 The Wellcome Trust Centre for the History of Medicine at UCL is funded by the Wellcome Trust, which is a registered charity, no. 210183. ISBN 978 085484 094 6 All volumes are freely available online at: www.history.qmul.ac.uk/research/modbiomed/wellcome_witnesses/ Please cite as: Christie D A, Tansey E M. (eds) (2003) Genetic Testing. Wellcome Witnesses to Twentieth Century Medicine, vol. 17. London: Wellcome Trust Centre for the History of Medicine at UCL. Key Front cover photographs, top to bottom: Professor Marcus Pembrey Dr Patricia Tippett Professor Doris Zallen Professor Sir David Weatherall, Professor Charles Rodeck Inside front cover photographs, top to bottom: Professor John Woodrow Professor Rodney Harris Professor John Edwards (1928–2007) Professor Sue Povey Back cover photographs, top to bottom: Professor Ursula Mittwoch Professor Malcolm Ferguson-Smith Professor Matteo Adinolfi Professor Paul Polani (1914–2006) Inside back cover photographs, top to bottom: Professor Matteo Adinolfi, Professor Paul Polani (1914–2006) Professor Paul Polani (1914–2006), Professor Rodney Harris Professor Bernadette Modell Mrs Cathy Holding, Professor Alan Handyside Genetic Testing (v19) 3/11/03 8:46 pm Page iii CONTENTS Illustrations v Introduction Professor Peter Harper vii Acknowledgements ix Witness Seminars: Meetings and publications xi E M Tansey and D A Christie Transcript Edited by D A Christie and E M Tansey 1 References 73 Biographical notes 91 Glossary 105 Index 115 Genetic Testing (v19) 3/11/03 8:46 pm Page iv Genetic Testing (v19) 3/11/03 8:46 pm Page v ILLUSTRATIONS Figure 1 Triploid cells in a human embryo, 1961.
    [Show full text]
  • The British Paediatric Surveillance Unit 30Th Anniversary Report Facilitating Childhood Rare Disease Research for Over 30 Years
    The British Paediatric Surveillance Unit 30th anniversary report Facilitating childhood rare disease research for over 30 years Secondary structure of a section of the HIV-1 RNA genome as determined by Watts et al. (Nature 460, 711– 716 (2009)) using the SHAPE technique. Nucleotides are represented as coloured dots, with the colours depicting the amount of SHAPE reactivity, which reflects nucleotide flexibility and base pairing. Reference: Al-Hashimi HM. Structural biology: Aerial view of the HIV genome. Nature 2009 Aug 6;460(7256): 696-698. doi:10.1038/460696a Contents 1 Message from HRH Princess Anne 2 Foreword from the Chief Medical Officer of England 3 Message from the BPSU Chair 4 Past & present faces 5 National rare disease surveillance 6 About the BPSU 7 Key partners & leaders 8 Rare Disease Day tea party events 9 Public & patient engagement 11 Policy & advocacy 12 Education for clinicians & researchers 14 BPSU through the ages 16 In the news... 17 Selected themes & impacts 24 Messages from clinicians & stakeholders 25 International activities 27 Looking forward 29 Conditions under surveillance Lynn RM, Avis JL, Reading R (eds). British Paediatric Surveillance Unit 30th anniversary report: Facilitating childhood rare disease research for over 30 years. © British Paediatric Surveillance Unit: London 2016 This report is available for download at www.rcpch.ac.uk/bpsu/30yearreport Message from HRH Princess Anne The British Paediatric Surveillance Unit (BPSU) was launched in 1986 and has facilitated research into uncommon childhood infections and disorders and importantly monitors emerging infections. No one could have predicted how effective its simple methodology of monthly reporting of rare disease by paediatricians would become.
    [Show full text]
  • Founding the British Association of Perinatal Medicine in Bristol in 1976* Peter M
    WEMJ Volume 116 No.1 Article 2 March 2017 Founding the British Association of Perinatal Medicine in Bristol in 1976* Peter M. Dunn, MA, MD, FRCP, FRCOG, Report in 1968 the domiciliary midwife underfunded. Many paediatricians were FRCPCH service had been disbanded. As a result singlehanded. In addition they were Emeritus professor of perinatal medicine our maternity hospitals had become based in children’s hospitals which were and child health, University of Bristol, UK over-crowded. There was pressure on often geographically situated apart from e-mail: [email protected] a rapid throughput of mothers with a maternity units. Paediatricians already high rate of surgical inductions and had their hands full coping with older use of accelerated labour. This led to infants and children. It is true that special * Address to the BAPM’s a rising rate of forceps deliveries and care baby units had been set up in the larger 40th AGM and Scientific Meeting, caesarean sections, with their associated maternity hospitals in the 1960s, but these Bristol, September 15th-16th, 2016 complications. were often ill-equipped and inadequately The care of newborn infants was also staffed, especially at a senior level. The dire. Traditionally they were the result of these deficiencies and problems responsibility of the obstetric team and was that the perinatal mortality in the UK were looked after by midwives and junior was five times higher than it need have I am grateful to Alan Fenton, our President, obstetric housemen, often with little or no been and that as many newborn infants for the opportunity to speak about the paediatric training.
    [Show full text]
  • Clinical Research in Britain 1950–1980
    Wellcome Witnesses to Twentieth Century Medicine CLINICAL RESEARCH IN BRITAIN 1950–1980 A Witness Seminar held at the Wellcome Institute for the History of Medicine, London, on 9 June 1998 Witness Seminar Transcript edited by L A Reynolds and E M Tansey Introduction by David Gordon Volume 7 – September 2000 CONTENTS Introduction David Gordon i Witness Seminars: Meetings and publications iii Transcript 1 Index 67 INTRODUCTION The British, it is said, are not revolutionary by nature. However, in the last century, we created two organizations that have revolutionized the possibility and reality of clinical research, with worldwide influence. The first was the formation of the Medical Research Council (MRC). The Medical Research Council was the successor of the Medical Research Committee, appointed in 1913 to administer funds provided under the National Health Insurance Act of 1911 (see note 49). While there may be doubt whether or not these funds were intended primarily for research into tuberculosis or for medical research more generally, we cannot doubt the boldness of the step. A government set aside money for medical research, rather than devoting the funds available for a medical problem solely to prevention, diagnosis and treatment. The second revolutionary step was the creation of the National Health Service. The National Health Service Act of 1946 gave Ministers powers not only to conduct research, but also to support the research work of others. The notion of a population- wide, compre h e n s i ve healthcare system, free to the patient at the point of consultation, and able to support the clinical infrastructure of research, was truly revolutionary, and might have been impossible were it not for the appetite for social change created by the Second World War.
    [Show full text]
  • University of Huddersfield Repository
    University of Huddersfield Repository Vasey, Jackie Poster presentation. Tokenism or True partnership: parental involvement in a child©s acute pain care Original Citation Vasey, Jackie (2016) Poster presentation. Tokenism or True partnership: parental involvement in a child©s acute pain care. In: Royal College of paediatrics and child health annual conference, 26-28th April 2016, Liverpool. (Unpublished) This version is available at http://eprints.hud.ac.uk/32250/ The University Repository is a digital collection of the research output of the University, available on Open Access. Copyright and Moral Rights for the items on this site are retained by the individual author and/or other copyright owners. Users may access full items free of charge; copies of full text items generally can be reproduced, displayed or performed and given to third parties in any format or medium for personal research or study, educational or not-for-profit purposes without prior permission or charge, provided: • The authors, title and full bibliographic details is credited in any copy; • A hyperlink and/or URL is included for the original metadata page; and • The content is not changed in any way. For more information, including our policy and submission procedure, please contact the Repository Team at: [email protected]. http://eprints.hud.ac.uk/ RCPCH Annual Conference 26-28 April 2016, Liverpool PROGRAMME The UK’s Largest Paediatric and Child Health Conference Working together across boundaries #RCPCH16 Conference layout UPPER LEVEL RIVERSIDE BALCONY CITYSIDE
    [Show full text]
  • Childhood Asthma and Beyond
    Wellcome Witnesses to Twentieth Century Medicine CHILDHOOD ASTHMA AND BEYOND A Witness Seminar held at the Wellcome Institute for the History of Medicine, London, on 4 April 2000 Volume 11 – November 2001 CONTENTS Introduction Mark Jackson i Witness Seminars: Meetings and publications;Acknowledgements E M Tansey and L A Reynolds vi Transcript Edited by L A Reynolds and E M Tansey 1 Index 67 INTRODUCTION One Sunday morning earlier this year, I was offered a potent and disturbing reminder of current trends in childhood asthma. Our one-year-old son, Conall, had developed a loud expiratory wheeze and persistent nocturnal cough following a series of debilitating upper respiratory tract infections and, perhaps significantly, coinciding with the extremely high pollen counts recorded that month. We had attempted to relieve the symptoms with a salbutamol inhaler delivered through a spacer and mask but to no effect. That morning, he began exhibiting signs of severe respiratory distress and I took him to the accident and emergency department in the small local hospital. He was given nebulized salbutamol which immediately eased both his (and my) distress and the wheeze, he was prescribed a short course of oral steroids and a follow- up steroid inhaler, and we were advised to see our GP later that week. Of course, our experience was by no means unusual. We all know families where young children suffer recurrent episodes of wheezing and nocturnal coughing, and where the use of both β-agonist and steroid inhalers is commonplace. When we lived in Manchester, where our older son, Riordan, first developed symptoms of asthma three or four years ago, our GP was insistent that the number of wheezy children seen in her surgery had increased dramatically over the previous ten years, particularly in those areas of Manchester close to major roads.
    [Show full text]
  • Prenatal Corticosteroids for Reducing Morbidity and Mortality After Preterm Birth
    PRENATAL CORTICOSTEROIDS FOR REDUCING MORBIDITY AND MORTALITY AFTER PRETERM BIRTH The transcript of a Witness Seminar held by the Wellcome Trust Centre for the History of Medicine at UCL, London, on 15 June 2004 Edited by L A Reynolds and E M Tansey Volume 25 2005 ©The Trustee of the Wellcome Trust, London, 2005 First published by the Wellcome Trust Centre for the History of Medicine at UCL, 2005 The Wellcome Trust Centre for the History of Medicine at UCL is funded by the Wellcome Trust, which is a registered charity, no. 210183. ISBN 0 85484 102 4 Histmed logo images courtesy of the Wellcome Library, London. All volumes are freely available online following the links to Publications/Wellcome Witnesses at www.ucl.ac.uk/histmed Technology Transfer in Britain:The case of monoclonal antibodies; Self and Non-Self: A history of autoimmunity; Endogenous Opiates; The Committee on Safety of Drugs • Making the Human Body Transparent: The impact of NMR and MRI; Research in General Practice; Drugs in Psychiatric Practice; The MRC Common Cold Unit • Early Heart Transplant Surgery in the UK • Haemophilia: Recent history of clinical management • Looking at the Unborn: Historical aspects of obstetric ultrasound • Post Penicillin Antibiotics: From acceptance to resistance? • Clinical Research in Britain, 1950–1980 • Intestinal Absorption • Origins of Neonatal Intensive Care in the UK • British Contributions to Medical Research and Education in Africa after the Second World War • Childhood Asthma and Beyond • Maternal Care • Population-based Research
    [Show full text]
  • Maternal Care Christie, DA; Tansey, EM
    View metadata, citation and similar papers at core.ac.uk brought to you by CORE provided by Queen Mary Research Online Maternal care Christie, DA; Tansey, EM For additional information about this publication click this link. http://qmro.qmul.ac.uk/jspui/handle/123456789/2776 Information about this research object was correct at the time of download; we occasionally make corrections to records, please therefore check the published record when citing. For more information contact [email protected] Wellcome Witnesses to Twentieth Century Medicine MATERNAL CARE A Witness Seminar held at the Wellcome Institute for the History of Medicine, London, on 6 June 2000 Volume 12 – November 2001 ©The Trustee of the Wellcome Trust, London, 2001 First published by the Wellcome Trust Centre for the History of Medicine at UCL, 2001 The Wellcome Trust Centre for the History of Medicine at UCL is funded by the Wellcome Trust, which is a registered charity, no. 210183. ISBN 978 085484 079 3 All volumes are freely available online at: www.history.qmul.ac.uk/research/modbiomed/wellcome_witnesses/ Please cite as: Christie D A, Tansey E M. (eds) (2001) Maternal Care. Wellcome Witnesses to Twentieth Century Medicine, vol. 12. London: Wellcome Trust Center for the History of Medicine at UCL. Key Front cover photographs, L to R from the top: Dr David Jewell Professor Peter Dunn, Professor Geoffrey Chamberlain, Mr Elliot Philipp (1915–2010) Miss Friedericke Eben, Dr Irvine Loudon, Mr Elliot Philipp (1915–2010) Mr Richard Porter, Dame Margaret Wheeler
    [Show full text]