Prenatal Corticosteroids for Reducing Morbidity and Mortality After Preterm Birth
Total Page:16
File Type:pdf, Size:1020Kb
Load more
Recommended publications
-
Genetic Testing
GENETIC TESTING The transcript of a Witness Seminar held by the Wellcome Trust Centre for the History of Medicine at UCL, London, on 13 July 2001 Edited by D A Christie and E M Tansey Volume 17 2003 CONTENTS Illustrations v Introduction Professor Peter Harper vii Acknowledgements ix Witness Seminars: Meetings and publications xi E M Tansey and D A Christie Transcript Edited by D A Christie and E M Tansey 1 References 73 Biographical notes 91 Glossary 105 Index 115 ILLUSTRATIONS Figure 1 Triploid cells in a human embryo, 1961. 20 Figure 2 The use of FISH with DNA probes from the X and Y chromosomes to sex human embryos. 62 v vi INTRODUCTION Genetic testing is now such a widespread and important part of medicine that it is hard to realize that it has almost all emerged during the past 30 years, with most of the key workers responsible for the discoveries and development of the field still living and active. This alone makes it a suitable subject for a Witness Seminar but there are others that increase its value, notably the fact that a high proportion of the critical advances took place in the UK; not just the basic scientific research, but also the initial applications in clinical practice, particularly those involving inherited disorders. To see these topics discussed by the people who were actually involved in their creation makes fascinating reading; for myself it is tinged with regret at having been unable to attend and contribute to the seminar, but with some compensation from being able to look at the contributions more objectively than can a participant. -
Prenatal Corticosteroids for Reducing Morbidity and Mortality After Preterm Birth
PRENATAL CORTICOSTEROIDS FOR REDUCING MORBIDITY AND MORTALITY AFTER PRETERM BIRTH The transcript of a Witness Seminar held by the Wellcome Trust Centre for the History of Medicine at UCL, London, on 15 June 2004 Edited by L A Reynolds and E M Tansey Volume 25 2005 ©The Trustee of the Wellcome Trust, London, 2005 First published by the Wellcome Trust Centre for the History of Medicine at UCL, 2005 The Wellcome Trust Centre for the History of Medicine at UCL is funded by the Wellcome Trust, which is a registered charity, no. 210183. ISBN 978 0 85484 102 8 Histmed logo images courtesy of the Wellcome Library, London. All volumes are freely available online at: www.history.qmul.ac.uk/research/modbiomed/wellcome_witnesses/ Please cite as: Reynolds L A, Tansey E M. (eds) (2005) Prenatal Corticosteroids for Reducing Morbidity and Mortality after Preterm Birth. Wellcome Witnesses to Twentieth Century Medicine, vol. 25. London: Wellcome Trust Centre for the History of Medicine at UCL. CONTENTS Illustrations and credits v Witness Seminars: Meetings and publications; Acknowledgements vii E M Tansey and L A Reynolds Introduction xxi Barbara Stocking Transcript 1 Edited by L A Reynolds and E M Tansey Appendix 1 85 Letter from Professor Sir Graham (Mont) Liggins to Sir Iain Chalmers (6 April 2004) Appendix 2 89 Prenatal glucocorticoids in preterm birth: a paediatric view of the history of the original studies by Ross Howie (2 June 2004) Appendix 3 97 Premature sheep and dark horses: Wellcome Trust support for Mont Liggins’ work, 1968–76 by Tilli Tansey (25 October 2005) Appendix 4 101 Prenatal corticosteroid therapy: early Auckland publications, 1972–94 by Ross Howie (January 2005) Appendix 5 103 Protocol for the use of corticosteroids in the prevention of respiratory distress syndrome in premature infants. -
James Spence Medallist, 1984
Arch Dis Child: first published as 10.1136/adc.59.9.805 on 1 September 1984. Downloaded from Archives of Disease in Childhood, 1984, 59, 805-806 James Spence Medallist, 1984 James William Bruce Douglas The James Spence Medal was presented to Dr James Douglas on 12 April 1984 by Sir Peter Tizard, President of the British Paediatric Association, who gave the following citation: The James Spence Medal was first struck in 1960, six years after the death of the man who was a founder member ofthe British Paediatric Association and its President in 1950-1, and whose name we wished to commemorate. Since then there have been 22 recipients of the Medal, either paediatricians or scientists, or both, and I like to think that Sir James would have approved of the choice of each and every one of them. But I am convinced that he would not have approved of any one of the highly distinguished past recipients of the Medal more than of Dr James William Bruce Douglas whose life work has been closely related to one of Sir James Spence's copyright. greatest interests in his professional life. Dr Douglas received his medical education at Magdalen College, Oxford and St Bartholomew's Hospital, qualifying BM in 1939. During his under- graduate career he had studied and written a thesis on 'Primate Behaviour' under the supervision of Dr Zuckerman. After qualification he continued to work in the Departments of Anatomy-and Physi- of babies were born in hospital and a mother to be http://adc.bmj.com/ ology in Oxford. -
The Impact of NMR and MRI
WELLCOME WITNESSES TO TWENTIETH CENTURY MEDICINE _____________________________________________________________________________ MAKING THE HUMAN BODY TRANSPARENT: THE IMPACT OF NUCLEAR MAGNETIC RESONANCE AND MAGNETIC RESONANCE IMAGING _________________________________________________ RESEARCH IN GENERAL PRACTICE __________________________________ DRUGS IN PSYCHIATRIC PRACTICE ______________________ THE MRC COMMON COLD UNIT ____________________________________ WITNESS SEMINAR TRANSCRIPTS EDITED BY: E M TANSEY D A CHRISTIE L A REYNOLDS Volume Two – September 1998 ©The Trustee of the Wellcome Trust, London, 1998 First published by the Wellcome Trust, 1998 Occasional Publication no. 6, 1998 The Wellcome Trust is a registered charity, no. 210183. ISBN 978 186983 539 1 All volumes are freely available online at www.history.qmul.ac.uk/research/modbiomed/wellcome_witnesses/ Please cite as : Tansey E M, Christie D A, Reynolds L A. (eds) (1998) Wellcome Witnesses to Twentieth Century Medicine, vol. 2. London: Wellcome Trust. Key Front cover photographs, L to R from the top: Professor Sir Godfrey Hounsfield, speaking (NMR) Professor Robert Steiner, Professor Sir Martin Wood, Professor Sir Rex Richards (NMR) Dr Alan Broadhurst, Dr David Healy (Psy) Dr James Lovelock, Mrs Betty Porterfield (CCU) Professor Alec Jenner (Psy) Professor David Hannay (GPs) Dr Donna Chaproniere (CCU) Professor Merton Sandler (Psy) Professor George Radda (NMR) Mr Keith (Tom) Thompson (CCU) Back cover photographs, L to R, from the top: Professor Hannah Steinberg, Professor -
Wellcome Witnesses to Twentieth Century Medicine: Volume 2 Tansey, EM; Christie, DA; Reynolds, LA
View metadata, citation and similar papers at core.ac.uk brought to you by CORE provided by Queen Mary Research Online Wellcome Witnesses to Twentieth Century Medicine: Volume 2 Tansey, EM; Christie, DA; Reynolds, LA For additional information about this publication click this link. http://qmro.qmul.ac.uk/jspui/handle/123456789/2746 Information about this research object was correct at the time of download; we occasionally make corrections to records, please therefore check the published record when citing. For more information contact [email protected] WELLCOME WITNESSES TO TWENTIETH CENTURY MEDICINE _____________________________________________________________________________ MAKING THE HUMAN BODY TRANSPARENT: THE IMPACT OF NUCLEAR MAGNETIC RESONANCE AND MAGNETIC RESONANCE IMAGING _________________________________________________ RESEARCH IN GENERAL PRACTICE __________________________________ DRUGS IN PSYCHIATRIC PRACTICE ______________________ THE MRC COMMON COLD UNIT ____________________________________ WITNESS SEMINAR TRANSCRIPTS EDITED BY: E M TANSEY D A CHRISTIE L A REYNOLDS Volume Two – September 1998 ©The Trustee of the Wellcome Trust, London, 1998 First published by the Wellcome Trust, 1998 Occasional Publication no. 6, 1998 The Wellcome Trust is a registered charity, no. 210183. ISBN 978 186983 539 1 All volumes are freely available online following the links to Publications/Wellcome Witnesses at www.ucl.ac.uk/histmed Please cite as : Tansey E M, Christie D A, Reynolds L A. (eds) (1998) Wellcome Witnesses to -
Genetic Testing (V19) 3/11/03 8:46 Pm Page I
Genetic Testing (v19) 3/11/03 8:46 pm Page i GENETIC TESTING The transcript of a Witness Seminar held by the Wellcome Trust Centre for the History of Medicine at UCL, London, on 13 July 2001 Edited by D A Christie and E M Tansey Volume 17 2003 ©The Trustee of the Wellcome Trust, London, 2003 First published by the Wellcome Trust Centre for the History of Medicine at UCL, 2003 The Wellcome Trust Centre for the History of Medicine at UCL is funded by the Wellcome Trust, which is a registered charity, no. 210183. ISBN 978 085484 094 6 All volumes are freely available online at: www.history.qmul.ac.uk/research/modbiomed/wellcome_witnesses/ Please cite as: Christie D A, Tansey E M. (eds) (2003) Genetic Testing. Wellcome Witnesses to Twentieth Century Medicine, vol. 17. London: Wellcome Trust Centre for the History of Medicine at UCL. Key Front cover photographs, top to bottom: Professor Marcus Pembrey Dr Patricia Tippett Professor Doris Zallen Professor Sir David Weatherall, Professor Charles Rodeck Inside front cover photographs, top to bottom: Professor John Woodrow Professor Rodney Harris Professor John Edwards (1928–2007) Professor Sue Povey Back cover photographs, top to bottom: Professor Ursula Mittwoch Professor Malcolm Ferguson-Smith Professor Matteo Adinolfi Professor Paul Polani (1914–2006) Inside back cover photographs, top to bottom: Professor Matteo Adinolfi, Professor Paul Polani (1914–2006) Professor Paul Polani (1914–2006), Professor Rodney Harris Professor Bernadette Modell Mrs Cathy Holding, Professor Alan Handyside Genetic Testing (v19) 3/11/03 8:46 pm Page iii CONTENTS Illustrations v Introduction Professor Peter Harper vii Acknowledgements ix Witness Seminars: Meetings and publications xi E M Tansey and D A Christie Transcript Edited by D A Christie and E M Tansey 1 References 73 Biographical notes 91 Glossary 105 Index 115 Genetic Testing (v19) 3/11/03 8:46 pm Page iv Genetic Testing (v19) 3/11/03 8:46 pm Page v ILLUSTRATIONS Figure 1 Triploid cells in a human embryo, 1961. -
James Spence Medallist 1983
Arch Dis Child: first published as 10.1136/adc.58.7.481 on 1 July 1983. Downloaded from Archives of Disease in Childhood, 1983, 58, 481-482 James Spence Medallist 1983 JOHN OLDROYD FORFAR building up a highly effective team, and with characteristic energy and determination creating a hospital environment in which the team could operate successfully. In paediatrics as a whole he built up a department in which all system specialties were represented, so that Edinburgh now provides a model paediatric service. John Forfar has been one of the most prolific contributors to the literature of paediatrics and his papers cover a wide range from basic science to social paediatrics. Two particular themes reveal his most consistent long term interests. The first is that of infantile calcium metabolism, hyper- and hypo- vitaminosis D, about which he first wrote in the 1950s and which he has continued to study-most recently in Saudi Arabia. The second subject is that of infection in the newborn. Like all his work his papers have combined scholarship with practical copyright. usefulness and good sense. John Forfar is a born teacher and lucky are the large number of young paediatricians who have received some or all of their postgraduate education in Edinburgh. One of his most important contri- butions to both teaching and the practice of paedi- http://adc.bmj.com/ atrics has been the text book edited jointly by him and Professor Gavin Arneil, but the format of which John Forfar qualified from the University of was conceived and designed by John Forfar in 1964. -
Founding the British Association of Perinatal Medicine in Bristol in 1976* Peter M
WEMJ Volume 116 No.1 Article 2 March 2017 Founding the British Association of Perinatal Medicine in Bristol in 1976* Peter M. Dunn, MA, MD, FRCP, FRCOG, Report in 1968 the domiciliary midwife underfunded. Many paediatricians were FRCPCH service had been disbanded. As a result singlehanded. In addition they were Emeritus professor of perinatal medicine our maternity hospitals had become based in children’s hospitals which were and child health, University of Bristol, UK over-crowded. There was pressure on often geographically situated apart from e-mail: [email protected] a rapid throughput of mothers with a maternity units. Paediatricians already high rate of surgical inductions and had their hands full coping with older use of accelerated labour. This led to infants and children. It is true that special * Address to the BAPM’s a rising rate of forceps deliveries and care baby units had been set up in the larger 40th AGM and Scientific Meeting, caesarean sections, with their associated maternity hospitals in the 1960s, but these Bristol, September 15th-16th, 2016 complications. were often ill-equipped and inadequately The care of newborn infants was also staffed, especially at a senior level. The dire. Traditionally they were the result of these deficiencies and problems responsibility of the obstetric team and was that the perinatal mortality in the UK were looked after by midwives and junior was five times higher than it need have I am grateful to Alan Fenton, our President, obstetric housemen, often with little or no been and that as many newborn infants for the opportunity to speak about the paediatric training. -
Clinical Research in Britain 1950–1980
Wellcome Witnesses to Twentieth Century Medicine CLINICAL RESEARCH IN BRITAIN 1950–1980 A Witness Seminar held at the Wellcome Institute for the History of Medicine, London, on 9 June 1998 Witness Seminar Transcript edited by L A Reynolds and E M Tansey Introduction by David Gordon Volume 7 – September 2000 CONTENTS Introduction David Gordon i Witness Seminars: Meetings and publications iii Transcript 1 Index 67 INTRODUCTION The British, it is said, are not revolutionary by nature. However, in the last century, we created two organizations that have revolutionized the possibility and reality of clinical research, with worldwide influence. The first was the formation of the Medical Research Council (MRC). The Medical Research Council was the successor of the Medical Research Committee, appointed in 1913 to administer funds provided under the National Health Insurance Act of 1911 (see note 49). While there may be doubt whether or not these funds were intended primarily for research into tuberculosis or for medical research more generally, we cannot doubt the boldness of the step. A government set aside money for medical research, rather than devoting the funds available for a medical problem solely to prevention, diagnosis and treatment. The second revolutionary step was the creation of the National Health Service. The National Health Service Act of 1946 gave Ministers powers not only to conduct research, but also to support the research work of others. The notion of a population- wide, compre h e n s i ve healthcare system, free to the patient at the point of consultation, and able to support the clinical infrastructure of research, was truly revolutionary, and might have been impossible were it not for the appetite for social change created by the Second World War. -
University of Huddersfield Repository
University of Huddersfield Repository Vasey, Jackie Poster presentation. Tokenism or True partnership: parental involvement in a child©s acute pain care Original Citation Vasey, Jackie (2016) Poster presentation. Tokenism or True partnership: parental involvement in a child©s acute pain care. In: Royal College of paediatrics and child health annual conference, 26-28th April 2016, Liverpool. (Unpublished) This version is available at http://eprints.hud.ac.uk/32250/ The University Repository is a digital collection of the research output of the University, available on Open Access. Copyright and Moral Rights for the items on this site are retained by the individual author and/or other copyright owners. Users may access full items free of charge; copies of full text items generally can be reproduced, displayed or performed and given to third parties in any format or medium for personal research or study, educational or not-for-profit purposes without prior permission or charge, provided: • The authors, title and full bibliographic details is credited in any copy; • A hyperlink and/or URL is included for the original metadata page; and • The content is not changed in any way. For more information, including our policy and submission procedure, please contact the Repository Team at: [email protected]. http://eprints.hud.ac.uk/ RCPCH Annual Conference 26-28 April 2016, Liverpool PROGRAMME The UK’s Largest Paediatric and Child Health Conference Working together across boundaries #RCPCH16 Conference layout UPPER LEVEL RIVERSIDE BALCONY CITYSIDE -
Professor Sir David Hull
Archives ofDisease in Childhood 1996;75:93-95 93 ARCHIVES OF DISEASE IN CHILDHOOD The Jtournal of the British Paediatric Association JAMES SPENCE MEDALLIST 1996 Professor Sir David Hull The 68th Annual Meeting ofthe British Paedi- atric Association (BPA) took place in York in April. During the meeting the President, Professor Roy Meadow, gave the following address before presenting the medal, and a vol- ume of the collective writings of Sir James Spence, to the medallist. The James Spence Medal is the premier award of our association. It commemorates Sir James Spence, Professor of Child Health in Newcastle, who was one of our founder mem- bers in 1928 and BPA President in 1950. The award is made for outstanding contributions to the advancement or clarification of paediatric knowledge; and today's recipient qualifies on both those grounds. David Hull was born in Blackburn, attended grammar school in Poulton-le-Fylde and, with the customary caution of a Lancastrian, unwilling to cross either the Mersey or the Pennines, he enrolled as a medical student at Liverpool University. After qualification he tissue found in hibernating animals and in the completed two years' national service in the human neonate, around the shoulder blades Royal Army Medical Corps, serving mainly at and the kidneys, with the capacity for rapid the British Military Hospital in Berlin. After- lipolysis and heat production. Several papers wards he returned to training posts in London. on that subject followed, so much so that in his A critical appointment for him was as Nuff- early years he was referred to as 'brown fat ield Research Fellow at the Institute for Medi- Hull'. -
Childhood Asthma and Beyond
Wellcome Witnesses to Twentieth Century Medicine CHILDHOOD ASTHMA AND BEYOND A Witness Seminar held at the Wellcome Institute for the History of Medicine, London, on 4 April 2000 Volume 11 – November 2001 CONTENTS Introduction Mark Jackson i Witness Seminars: Meetings and publications;Acknowledgements E M Tansey and L A Reynolds vi Transcript Edited by L A Reynolds and E M Tansey 1 Index 67 INTRODUCTION One Sunday morning earlier this year, I was offered a potent and disturbing reminder of current trends in childhood asthma. Our one-year-old son, Conall, had developed a loud expiratory wheeze and persistent nocturnal cough following a series of debilitating upper respiratory tract infections and, perhaps significantly, coinciding with the extremely high pollen counts recorded that month. We had attempted to relieve the symptoms with a salbutamol inhaler delivered through a spacer and mask but to no effect. That morning, he began exhibiting signs of severe respiratory distress and I took him to the accident and emergency department in the small local hospital. He was given nebulized salbutamol which immediately eased both his (and my) distress and the wheeze, he was prescribed a short course of oral steroids and a follow- up steroid inhaler, and we were advised to see our GP later that week. Of course, our experience was by no means unusual. We all know families where young children suffer recurrent episodes of wheezing and nocturnal coughing, and where the use of both β-agonist and steroid inhalers is commonplace. When we lived in Manchester, where our older son, Riordan, first developed symptoms of asthma three or four years ago, our GP was insistent that the number of wheezy children seen in her surgery had increased dramatically over the previous ten years, particularly in those areas of Manchester close to major roads.