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SUPPLEMENTAL MATERIAL the China Patient-Centered Evaluative Assessment of Cardiac Events

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SUPPLEMENTAL MATERIAL the China Patient-Centered Evaluative Assessment of Cardiac Events SUPPLEMENTAL MATERIAL The China Patient-centered Evaluative Assessment of Cardiac Events (PEACE) Prospective Heart Failure Study Design Xinghe Huang, MS; Yuan Yu, MD; Xi Li, MD, PhD; Fredrick A. Masoudi, MD, MSPH; John A. Spertus, MD, MPH; Xiaofang Yan, MD; Harlan M. Krumholz*, MD, SM; Lixin Jiang*, MD, PhD; Jing Li*, MD, PhD (*joint senior authors) National Clinical Research Center of Cardiovascular Diseases, State Key Laboratory of Cardiovascular Disease (XH, YY, XL, XY, LJ, JL), Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, People’s Republic of China; Division of Cardiology (FAM), University of Colorado Anschutz Medical Campus, Aurora, Colorado, United States; Saint Luke’s Mid America Heart Institute (JAS), Kansas City, Missouri, United States; University of Missouri - Kansas City, School of Medicine (JAS), Kansas City, Missouri, United States; Center for Outcomes Research and Evaluation (HMK), Yale-New Haven Hospital, and Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut, United States; Department of Health Policy and Management (HMK), Yale School of Public Health, New Haven, Connecticut, United States; Section of Cardiovascular Medicine (HMK), Robert Wood Johnson Clinical Scholars Program (HMK), Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut, United States. TABLE OF CONTENTS Supplementary 1: PEACE-Prospective HF Study Site Investigators by Hospital Supplementary 2: PEACE-Prospective HF Study Instrument Validation Supplementary 3: PEACE-Prospective HF Study Baseline and Follow-up Questionnaires Supplementary 4: PEACE-Prospective HF Study Impedance Cardiogram Parameter Supplementary 5: PEACE-Prospective HF Study Blood and Urine Collection Supplementary 6: PEACE-Prospective HF Study Case Report Form Supplementary 7: PEACE-Prospective HF Study Data Dictionary Supplementary 8: PEACE-Prospective HF Study Analytic Methods and Plan Supplementary 9: PEACE-Prospective HF Study Sample Size Calculation Supplementary 1: PEACE-Prospective Heart Failure Study Site Investigators by Hospitals Province/ Hospital PI Study Investigator Municipality The Center Hospital of Dang Hongbo, Yang Wenxue, Zhao Anhui Qian Jun Maanshan Xiaoli, Chen Ying Beijing Fuwai Hospital Zhang Yuhui Beijing Chaoyang Hospital， Liu Wenting, Zong Min, Jiang Beijing Wei Yu Capital Medical University Pengcheng, Li Qiang Fang Su Wei, Jia Wenfang, Wei Dongwei, Beijing Beijing Liangxiang Hospital Xuehua Shang Guangyun The First Affiliated Hospital Huang longxiang, Zeng yuwei, Yuan Chongqing Luo Suxin of Chongqing Medical University Xiao, Zhao ruohan Xiamen Cardiovascular Hospital Yao Yaner, Zeng zhaoping, Zhang Fujian Dai Cuilian Xiamen University Guoming, Wang Guixiang The Second Affiliated Hospital of Cui He Wenkai, Li Mingyan, Mei Xiao, Lin Guangdong GZMU Yongsheng Lan Li Liwen, Zhang Ying, Xia Shuang, Yi Guangdong Guangdong General Hospital Chen Jiyan Shixin, Mo Yujing The People's Hospital of Guangxi Wu Guangxi Xu Nengwen, Song Qiuyun, Shi Xun Zhuang Autonomous Region Guangwei The First Affiliated Hospital of Zhang Pengxiang, Du Meiling, Wang Hebei Li Fangjiang Hebei North University Xiaoyuan, Wang Yaling The First Affiliated Hospital of Yuan Qianqian, Yuan Xiaowei, Chen Xi, Henan Fu Xin Zhengzhou University Zhang Lili Wang Su Shuhong, Li Yan, Qi Junjie, Hou Henan Xinxiang Central Hospital Zhifang Yonglan, Tian Xianwei Wang Henan Puyang Oilfield General Hospital Feng Zhikuan, Xu Qingbo Hengliang Henan Qinyang People’s Hospital Ma Xiaowen Liang Yanli, Wang Tianbiao, Yang Jing Henan Luoyang Dongfang Hospital Zhang Ge Li Tongshe, Cao Lei, Jin Feipeng The First Affiliated Hospital of Tang Li Yueyan, Zhang Jingjing, Tan Ying, Lu Hunan University of South China Huifang Taotao Xing Hunan Brain Hospital of Hunan Province Zhang Chen Zuzhong Inner Li Li, Han Zhaoxi, Hao Yiming, Gong Baogang Hospital Li Yongdong Mongolia Libin Inner The Second Affiliated Hospital of Yue Jianwei, Yang Xiaomin, Zhao Sun Gang Mongolia Baotou Medical College Zhixian The Affiliated People Hospital of Inner Inner Mongolia Medical Liu Juan Xia Jun, Wu Yongli, Geng Leijun Mongolia University Inner Mongolia Autonomous Inner Qiao Yu, Zhang Xuefeng, Huang Region Hospital of Traditional Su He Mongolia Xinsheng, Zhang Ruifen Chinese Medicine Inner Wang Haifeng, Long Weiying, Yin Inner Mongolia People's Hospital Han Yajun Mongolia Haijun Inner Cui Kang Yinghui, Wang Xin, Ma Liwei, Hulunbeier People's Hospital Mongolia Zhonghua Rong Di, Zhao Ling Inner International Mongolia Hospital of Mo Rigentu Guo Yong, Zhang Shuanglin Mongolia Inner Mongolia The Second Affiliated Hospital of Jiangsu Wu Weiheng Zhang Sai, Li Li, Su Liqifu Xuzhou Medical University The Affiliated Hospital of Xuzhou Luo Yuanyua, Zhai Yuting, Zhang Jiangsu Li Dongye Medical University Yuanyuan The First Hospital of Jilin Jilin Zheng Yang Liu Zhaoxi, Zou Lin, Sun Hong, Ma Kai University China-Japan Union Hospital of Li Bing, Feng Zhaohui, Li Jiayu, Wang Jilin Yang Ping Jilin University Ying, Liu Jinsha Shenyang the Fourth Hospital of Liaoning Li Yinjun Zhou Xiaolong, Li Xin People Liaoning Shenyang First People's Hospital Xu Jian Zhai Na, Wu Fang, Song Pingmei Affiliated Zhongshan Hospital of Liaoning Yu Qin Liang Shunji, Bai Qianru Dalian University Wang Yang, Zhang Xuan, Wang Liaoning Benxi Jinshan Hospital Xiu Guoquan Shouli, Tang Liping Liaoning Xinmin Peoples' Hospital Qi Liwei Li Tongying Central Hospital of Shenyang Liaoning Che Hang Sun Chengxiang, Li Dajun Sujiatun District Liaoning Anshan Changda Hospital Jin Xiang Cai Ting Qinghai Cardiovascular and Zhou Wei, Xu Jingping, Wang Hong, Qinghai Ma Xiaofeng Cerebrovascular Hospital Deng Yong, Jin Renbo Jiang Dong Yumei, Zhang Bin, Hu Shandong Qingdao Fuwai Hospital Xianyan Wenchuan, Lu Min, Ma Aiqing Affiliated Hospital of Jining Zhang Wei Xiqing, Song Bingchun, Li Weilin, Shandong Medical University Jinguo Fan Dongchen Shanxi Xi’an No.1 Hospital Ji Yuqiang Zhan Xiaojun, Li Xia The First Affiliated Hospital of Xi Li Jingjin, Li Tiaotiao, Lei Jianghong, Shanxi Ren Jie 'an Jiaotong University Tian Yuling, Zhuo Xiaozhen Shanxi Shanxi Fenyang Hospital Li Li Zhai Xiaojuan, Liang Jiancheng, Jia Kaijian The Second Hospital of Shanxi Yang Yang Huiyu, Liu Jiajia, Li Sumei, Wu Shanxi Medical University Zhiming Yalin, Yin Xia Chen Shanxi Taiyuan City Central Hospital Huolijuan, Han Chunli Xiaoping Shangguan Zhaohui, Wang Qiang, Shanxi Quwo County People's Hospital Wu Zhenlin Guan Caixia, Wang Jianmin Hospital of Chendu Office of Sichuan People's Government of Tibetan Zhou Yao Zhao Liming, Liu lanxin, Xu Qing Autonomous Region Sichuan AVIC 363 Hospital Ning Liang Wu Xiaowei, Cui Yong, Luo Lian Sichuan Nanchong Central Hospital Wang Haoyu Li Yanhua, Yin Wen, Luo Xiaorong First Affiliated Hospital of Shi Yunke, Mao Juncong, Zhang Yunnan Cai Hongyan Kunming Medical University Guoju, Jing Pan, Bao Yonghong Taizhou Hospital of Zhejiang Zhejiang Jiang Jianjun Mi Yafei, Zhu Jia Province Zhejiang Zhejiang Hospital Yan Jing Yu Yihua, Wang Yan, Chen Shaoxi The Affiliated Yueqing Hospital of Zhejiang Yu Xudong Wang Qiu, Chen Tingting Wenzhou Medical University, Zhejiang Ningbo First Hospital Cui Hanbin Zhang Zhaoxia, Zhao Ruochi China PEACE 5-HF Prospective Study Supplementary 2: PEACE-Prospective Heart Failure Study Instrument Validation among Chinese Participants Participants Instruments Author/date Study design N Results characteristics Almost all of the intra-cronbach’s α is larger than 0.8 except the self Sampling: consecutive recruitment efficacy domain. Source: the first affiliated hospital of Among 24 stable CHF patients, Sun Yatsen University Cardiologic minimal changes were detected Department Chronic heart after three months later. KCCQ-2314 Deng YH 2010 96 Time: September 2002 to January failure The KCCQ-12 is a shorter version 2003 of the original 23-item instrument Test-retest reliability at 3-months that should be more feasible to intervals implement while preserving the psychometric properties of the full instrument.13 Sampling: multistage stratified random sampling Kappa values for five items were Source: 18 communities of General from 0.35 to 1.0. EQ-5D16 Wang HM 2012 Hangzhou, China 1747 population Test–retest reliability (intraclass Time: 2008 correlation coefficient = 0.53) Test-retest reliability at 2-week intervals Sampling: multistage Internal consistency (Cronbach's cluster-sampling α =0.76) Source: rural areas of Liuyang Sensitivity: 0.9 PHQ-217 Liu ZW 2016 County aged ≥ 60 839 Specificity: 0.9 Time: November 2010 to August AUC, (95% CI): 0.94 (0.90–0.97) 2011 Youden Index: 0.79 PSS18 Leung DY 2010 Source: cardiac outpatient clinics of Cardiac patients 1860 Internal consistency of the full 6 / 158 China PEACE 5-HF Prospective Study ten acute hospitals in Hong Kong who smoke scales (Cronbach's α=0.67, 0.83, Time: March 2002 to December . 0.85 for PSS-4, PSS-10, PSS-14) 2004 Internal consistency (Cronbach's α=0.89) Sampling: consecutive recruitment ROC area under the curve was Source: epilepsy outpatient clinic of Epilepsy 0.97 (95% CI=0.96-0.99). GAD-719 Tong X 2016 213 West China Hospital The GAD-7 and GAD-2 are both Time: March to May 2015 reliable and valid screening instruments for GAD in patients with migraine.18 Sensitivity, % (95% CI): 87.61 Sampling: multistage stratified (85.92–90.02) random cluster sampling Specificity, % (95% CI): 85.30 Source: 4 communities across 12 (83.07–87.92) Mini-cog21
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