Thoracic Aortic Aneurysm
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Of the Pediatric Mediastinum
MRI of the Pediatric Mediastinum Dianna M. E. Bardo, MD Director of Body MR & Co-Director of the 3D Innovation Lab Disclosures Consultant & Speakers Bureau – honoraria Koninklijke Philips Healthcare N V Author – royalties Thieme Publishing Springer Publishing Mediastinum - Anatomy Superior Mediastinum thoracic inlet to thoracic plane thoracic plane to diaphragm Inferior Mediastinum lateral – pleural surface anterior – sternum posterior – vertebral bodies Mediastinum - Anatomy Anterior T4 Mediastinum pericardium to sternum Middle Mediastinum pericardial sac Posterior Mediastinum vertebral bodies to pericardium lateral – pleural surface superior – thoracic inlet inferior - diaphragm Mediastinum – MR Challenges Motion Cardiac ECG – gating/triggering Breathing Respiratory navigation Artifacts Intubation – LMA Surgical / Interventional materials Mediastinum – MR Sequences ECG gated/triggered sequences SSFP – black blood SE – IR – GRE Non- ECG gated/triggered sequences mDIXON (W, F, IP, OP), eTHRIVE, turbo SE, STIR, DWI Respiratory – triggered, radially acquired T2W MultiVane, BLADE, PROPELLER Mediastinum – MR Sequences MRA / MRV REACT – non Gd enhanced Gd enhanced sequences THRIVE, mDIXON, mDIXON XD Mediastinum – Contents Superior Mediastinum PVT Left BATTLE: Phrenic nerve Vagus nerve Structures at the level of the sternal angle Thoracic duct Left recurrent laryngeal nerve (not the right) CLAPTRAP Brachiocephalic veins Cardiac plexus Aortic arch (and its 3 branches) Ligamentum arteriosum Thymus Aortic arch (inner concavity) Trachea Pulmonary -
Thoracic Aorta
GUIDELINES AND STANDARDS Multimodality Imaging of Diseases of the Thoracic Aorta in Adults: From the American Society of Echocardiography and the European Association of Cardiovascular Imaging Endorsed by the Society of Cardiovascular Computed Tomography and Society for Cardiovascular Magnetic Resonance Steven A. Goldstein, MD, Co-Chair, Arturo Evangelista, MD, FESC, Co-Chair, Suhny Abbara, MD, Andrew Arai, MD, Federico M. Asch, MD, FASE, Luigi P. Badano, MD, PhD, FESC, Michael A. Bolen, MD, Heidi M. Connolly, MD, Hug Cuellar-Calabria, MD, Martin Czerny, MD, Richard B. Devereux, MD, Raimund A. Erbel, MD, FASE, FESC, Rossella Fattori, MD, Eric M. Isselbacher, MD, Joseph M. Lindsay, MD, Marti McCulloch, MBA, RDCS, FASE, Hector I. Michelena, MD, FASE, Christoph A. Nienaber, MD, FESC, Jae K. Oh, MD, FASE, Mauro Pepi, MD, FESC, Allen J. Taylor, MD, Jonathan W. Weinsaft, MD, Jose Luis Zamorano, MD, FESC, FASE, Contributing Editors: Harry Dietz, MD, Kim Eagle, MD, John Elefteriades, MD, Guillaume Jondeau, MD, PhD, FESC, Herve Rousseau, MD, PhD, and Marc Schepens, MD, Washington, District of Columbia; Barcelona and Madrid, Spain; Dallas and Houston, Texas; Bethesda and Baltimore, Maryland; Padua, Pesaro, and Milan, Italy; Cleveland, Ohio; Rochester, Minnesota; Zurich, Switzerland; New York, New York; Essen and Rostock, Germany; Boston, Massachusetts; Ann Arbor, Michigan; New Haven, Connecticut; Paris and Toulouse, France; and Brugge, Belgium (J Am Soc Echocardiogr 2015;28:119-82.) TABLE OF CONTENTS Preamble 121 B. How to Measure the Aorta 124 I. Anatomy and Physiology of the Aorta 121 1. Interface, Definitions, and Timing of Aortic Measure- A. The Normal Aorta and Reference Values 121 ments 124 1. -
Blood Vessels
BLOOD VESSELS Blood vessels are how blood travels through the body. Whole blood is a fluid made up of red blood cells (erythrocytes), white blood cells (leukocytes), platelets (thrombocytes), and plasma. It supplies the body with oxygen. SUPERIOR AORTA (AORTIC ARCH) VEINS & VENA CAVA ARTERIES There are two basic types of blood vessels: veins and arteries. Veins carry blood back to the heart and arteries carry blood from the heart out to the rest of the body. Factoid! The smallest blood vessel is five micrometers wide. To put into perspective how small that is, a strand of hair is 17 micrometers wide! 2 BASIC (ARTERY) BLOOD VESSEL TUNICA EXTERNA TUNICA MEDIA (ELASTIC MEMBRANE) STRUCTURE TUNICA MEDIA (SMOOTH MUSCLE) Blood vessels have walls composed of TUNICA INTIMA three layers. (SUBENDOTHELIAL LAYER) The tunica externa is the outermost layer, primarily composed of stretchy collagen fibers. It also contains nerves. The tunica media is the middle layer. It contains smooth muscle and elastic fiber. TUNICA INTIMA (ELASTIC The tunica intima is the innermost layer. MEMBRANE) It contains endothelial cells, which TUNICA INTIMA manage substances passing in and out (ENDOTHELIUM) of the bloodstream. 3 VEINS Blood carries CO2 and waste into venules (super tiny veins). The venules empty into larger veins and these eventually empty into the heart. The walls of veins are not as thick as those of arteries. Some veins have flaps of tissue called valves in order to prevent backflow. Factoid! Valves are found mainly in veins of the limbs where gravity and blood pressure VALVE combine to make venous return more 4 difficult. -
Fetal Descending Aorta/Umbilical Artery Flow Velocity Ratio in Normal Pregnancy at 36-40 Weeks of Gestational Age Riyadh W Alessawi1
American Journal of BioMedicine AJBM 2015; 3(10):674 - 685 doi:10.18081/2333-5106/015-10/674-685 Fetal descending aorta/umbilical artery flow velocity ratio in normal pregnancy at 36-40 Weeks of gestational age Riyadh W Alessawi1 Abstract Doppler velocimetry studies of placental and aortic circulation have gained a wide popularity as it can provide important information regarding fetal well-being and could be used to identify fetuses at risk of morbidity and mortality, thus providing an opportunity to improve fetal outcomes. Prospective longitudinal study conducted through the period from September 2011–July 2012, 125 women with normal pregnancy and uncomplicated fetal outcomes were recruited and subjected to Doppler velocimetry at different gestational ages, from 36 to 40 weeks. Of those, 15 women did not fulfill the protocol inclusion criteria and were not included. In the remaining 110 participants a follow up study of Fetal Doppler velocimetry of Ao and UA was performed at 36 – 40 weeks of gestation. Ao/UA RI: 1.48±0.26, 1.33±0.25, 1.37± 0.20, 1.28±0.07 and 1.39±0.45 respectively and the 95% confidence interval of the mean for five weeks 1.13-1.63. Ao/UA PI: 2.83±2.6, 1.94±0.82, 2.08±0.53, 1.81± 0.12 and 3.28±2.24 respectively. Ao/UA S/D: 2.14±0.72, 2.15±1.14, 1.75±0.61, 2.52±0.18 and 2.26±0.95. The data concluded that a nomogram of descending aorto-placental ratio Ao/UA, S/D, PI and RI of Iraqi obstetric population was established. -
Next-Generation Sequencing for Diagnosis of Thoracic Aortic Aneurysms and Dissections: Diagnostic Yield, Novel Mutations And
Poninska et al. J Transl Med (2016) 14:115 DOI 10.1186/s12967-016-0870-4 Journal of Translational Medicine RESEARCH Open Access Next‑generation sequencing for diagnosis of thoracic aortic aneurysms and dissections: diagnostic yield, novel mutations and genotype phenotype correlations J. K. Poninska1, Z. T. Bilinska2*, M. Franaszczyk1, E. Michalak2, M. Rydzanicz3, E. Szpakowski4, A. Pollak5, B. Milanowska2, G. Truszkowska1, P. Chmielewski2, A. Sioma2, H. Janaszek‑Sitkowska6, A. Klisiewicz7, I. Michalowska8, M. Makowiecka‑Ciesla6, P. Kolsut4, P. Stawinski3,5, B. Foss‑Nieradko2, M. Szperl1, J. Grzybowski9, P. Hoffman7, A. Januszewicz6, M. Kusmierczyk4 and R. Ploski3* Abstract Background: Thoracic aortic aneurysms and dissections (TAAD) are silent but possibly lethal condition with up to 40 % of cases being hereditary. Genetic background is heterogeneous. Recently next-generation sequencing enabled efficient and cost-effective examination of gene panels. Aim of the study was to define the diagnostic yield of NGS in the 51 TAAD patients and to look for genotype–phenotype correlations within families of the patients with TAAD. Methods: 51 unrelated TAAD patients were examined by either whole exome sequencing or TruSight One sequenc‑ ing panel. We analyzed rare variants in 10 established thoracic aortic aneurysms-associated genes. Whenever possible, we looked for co-segregation in the families. Kaplan–Meier survival curve was constructed to compare the event-free survival depending on genotype. Aortic events were defined as acute aortic dissection or first planned aortic surgery. Results and discussion: In 21 TAAD patients we found 22 rare variants, 6 (27.3 %) of these were previously reported, and 16 (73.7 %) were novel. -
Inferior Phrenic Artery, Variations in Origin and Clinical Implications – a Case Study
IOSR Journal of Dental and Medical Sciences (IOSR-JDMS) E-ISSN: 2279-0853, p-ISSN: 2279-0861. Volume 7, Issue 6 (Mar.- Apr. 2013), PP 46-48 www.iosrjournals.org Inferior Phrenic Artery, Variations in Origin and Clinical Implications – A Case Study 1 2 3 Dr.Anupama D, Dr.R.Lakshmi Prabha Subhash .Dr. B.S Suresh Assistant Professor. Dept. Of Anatomy, SSMC. Tumkur.Karnataka.India Professor & HOD. Dept. Of Anatomy, SSMC. Tumkur.Karnataka.India Associate professor.Dept. Of Anatomy, SSMC. Tumkur.Karnataka.India Abstract:Variations in the branching pattern of abdominal aorta are quite common, knowledge of which is required to avoid complications during surgical interventions involving the posterior abdominal wall. Inferior Phrenic Arteries, the lateral aortic branches usually arise from Abdominal Aorta ,just above the level of celiac trunk. Occasionally they arise from a common aortic origin with celiac trunk, or from the celiac trunk itself or from the renal artery. This study describes the anomalous origin of this lateral or para aortic branches in the light of embryological and surgical basis. Knowledge of such variations has important clinical significance in abdominal operations like renal transplantation, laparoscopic surgery, and radiological procedures in the upper abdomen or invasive arterial procedures . Keywords: Abdominal Aorta, Celiac Trunk(Ct), Diaphragm, Inferior Phrenic Artery (Ipa), Retro Peritoneal, Renal Artery(Ra). I. Introduction The abdominal aorta begins from the level of 12th thoracic vertebra after passing through the Osseo aponeurotic hiatus of diaphragm. It courses downwards with Inferior vena cava to its right and terminates at the level of 4th lumbar vertebra by dividing in to two terminal branches. -
Vascular Surgery
Vascular surgery Dr.Lukáč Jakub FN Brno –Trauma dept. ...little bit of history first Studies on egyptian mummies revealed, that people more than 3500 yrs back suffer from atherosclerosis Ebers Papyrus (2000 b.c.)-identified peripheral arterial aneurysms, and suggested forms of treatment , e.g. „treat it with a knife, and burn it with a fire, so it doesnt bleed so much“ LOL :D Hippokrates (400 b.c.) – treated hemorrhoids by putting a red – hot iron in patients anus (first cautherization) Antyllus (2 century a.d.)- invented a ligature system, in which he applied ligatures to arteries entering and leaving the aneurysm, then cutting the sac of aneurysm, and packing the cavity Ambroise Paré (16th century) – starts using ligations, stops with boiling oil and cautherization Dark ages treatment of hemorrhoids with hot iron Please, kill me! What is vascular surgery? Vascular surgery is surgical subspecialty, which is dealing with diseases of vascular system, including lymphatic venous system. Todays trend is to treat as much as possible conservatively, with medication, or using minimally – invasive procedures. When need arises, open surgery of vascular reconstruction is done. Vascular surgeon treats vascular problems,except for heart and brain vacular conditions. What are the most common vascular diseases? Abdominal aortic aneurysm Aortic dissection Atherosclerosis Chronic venous insufficiency Deep venous thrombosis Peripheral arterial disease Thoracic aortic aneurysm Varicose veins Haemorrhoids Vascular trauma Pulmonary embolism Lymphedema Carotid artery disease and other.... Aneurysms Abnormal, localized weak spot on artery wall, that causes the wall to bulge outward, like a baloon. Aneurysms may be divided due to localization, shape, or mural structure. -
Surgical Indications. a Critical Point of View
Surgical indications in ascending aorta aneurysms: What do we know? Jean-Luc MONIN, MD, PhD. Institut Mutualiste Montsouris, Paris, FRANCE Disclosures related to this talk : www.imm.fr NONE 2 Clinical case www.imm.fr • A 40 year-old woman • Height: 172 cm/ Weight: 70 kg • Ascending aortic aneurysm • She wants to become pregnant (3-year old kid) • No Marfan syndrome or bicuspid AV • Younger sister: sudden unexplained death (at 18 years old) • 2012 (MRI): Valsalva: 42 mm, tubular: 43 mm • 2013 (MRI): Valsalva: 40 mm, tubular: 45 mm 3 www.imm.fr www.imm.fr www.imm.fr www.imm.fr www.imm.fr www.imm.fr What would we advise to this woman www.imm.fr ? A. Pregnancy is temporarily contra indicated, MRI or cardiac CT is needed B. No contra indication for pregnancy, TTE or MRI at 1 year 10 Thoracic aortic aneurysm www.imm.fr Thoracic Aortic Aneurysm: An indolent but virulent process www.imm.fr Ascending Aorta 1 mm/ year 45 mm 60 mm 3 mm/ year 34% Rate of aortic dilatation is EXPONENTIAL • Expansion rate ≈ 2.1 mm/ year for an initial diameter of 35-40 mm (%) rupture dissection/ of risk Lifetime Aortic diameter (cm) • Expansion rate ≈ 5.6 mm/ year for aneurysms ≥ 60 mm Coady et al. J Thorac Cardiovasc Surg. 1997;113: 476 Mechanical properties of human ascending aorta : >6 cm is the limit www.imm.fr Exponential relationship between wall stress and aneurysm size in ascending aortic aneurysms. • Pink columns : SBP =100 mm Hg • Purple columns : SBP = 200 mm Hg • Range of maximum tensile strength of the human aorta : 800 to 1,000 kPa Koullias et al. -
Aorta and the Vasculature of the Thorax
Aorta and the Vasculature of the Thorax Ali Fırat Esmer, MD Ankara University Faculty of Medicine Department of Anatomy THE AORTA After originating from left ventricle, it ascends for a short distance, arches backward and to the left side, descends within the thorax on the left side of the vertebral column It is divided for purposes of The aorta is the main arterial trunk description into: that delivers oxygenated blood from Ascending aorta the left ventricle of the heart to the Arch of the aorta and tissues of the body. Descending aorta (thoracic and abdominal aorta) Ascending Aorta The ascending aorta begins at the base of the left ventricle runs upward and forward at the level of the sternal angle, where it becomes continuous with the arch of the aorta it possesses three bulges, the sinuses of the aorta Branches Right coronary artery Left coronary artery ARCH OF THE AORTA The aortic arch is a continuation of the ascending aorta and begins at the level of the second sternocostal joint. • It arches superiorly, posteriorly and to the left before moving inferiorly. • The aortic arch ends at the level of the T4 vertebra / at level of sternal angle. Branches; Brachiocephalic artery (Innominate artery) Left common carotid artery Left subclavian artery It begins when the ascending aorta emerges from the pericardial sac and courses upward, backward, and to the left as it passes through the superior mediastinum, ending on the left side at vertebral level TIV/V. Extending as high as the midlevel of the manubrium of the sternum, the arch is initially anterior and finally lateral to the trachea. -
Aneurysm of the Ascending Aorta Presenting with Pulmonary Stenosis
Thorax: first published as 10.1136/thx.21.3.236 on 1 May 1966. Downloaded from Thorax (1966), 21, 236. Aneurysm of the ascending aorta presenting with pulmonary stenosis M. H. YACOUB, M. V. BRAIMBRIDGE,1 AND R. G. GOLD From the Brornpton Hospital, London S.W.3 The symptoms and signs of aneurysms of the The chest radiograph (Fig. 1) showed old bilateral thoracic aorta are due mainly to compression of apical tuberculosis, and both lungs were emphyse- surrounding mediastinal structures and depend on matous. The emphysema was most marked in the left the size and location of the aneurysm. Compres- upper lobe with bullae present. A hemispherical mass, sion of the trachea, bronchi, oesophagus, recurrent 9 by 6 cm., lay to the left and in front of the ascend- ing aorta. Its border was slightly irregular. and laryngeal nerve, bone, and superior vena cava is showed flecks of linear calcification laterally and common, but pressure on the pulmonary artery has superiorly. The heart size was within normal limits. not been described in spite of its intimate relation At right heart catheterization difficulty was experi- to the ascending aorta. enced in passing the catheter into the pulmonary The object of this paper is to describe a case artery. The right ventricular systolic pressure was presenting in this way and to discuss the particular 44 mm. Hg and the pulmonary artery systolic pres- surgical problems involved in the excision of such sure was 18 mm. Hg. the systolic gradient being 24 an aneurysm. mm. Hg, with a single change in pressure fromarterial to ventricular configuration in the vicinity of the pulmonary valve. -
Superior Mesenteric Artery and Nutcracker Syndromes in a Healthy 14-Year-Old Girl Requiring Surgical Intervention After Failed Conservative Management
ISSN 2377-8369 GASTRO Open Journal Case Report Superior Mesenteric Artery and Nutcracker Syndromes in a Healthy 14-Year-Old Girl Requiring Surgical Intervention after Failed Conservative Management David Wood, MRCPCH, MSc1; Andrew Fagbemi, FRCPCH2; Loveday Jago, MRCPCH2; Dalia Belsha, MRCPCH2; Nick Lansdale, FRCS, PhD3; Ahmed Kadir, FRCPCH, MSc2* 1Paediatric Registrar, Royal Manchester Children’s Hospital, Manchester, UK 2Paediatric Gastroenterology Consultant, Royal Manchester Children’s Hospital, Manchester, UK 3Paediatric Surgeon, Royal Manchester Children’s Hospital, Manchester, UK *Corresponding author Ahmed Kadir, FRCPCH, MSc Paediatric Gastroenterology Consultant, Royal Manchester Children’s Hospital, Manchester, UK; Phone. 07709732356; E-mail: [email protected] Article information Received: January 30th, 2020; Revised: February 17th, 2020; Accepted: February 24th, 2020; Published: February 28th, 2020 Cite this article Wood D, Fagbemi A, Jago L, Belsha D, Lansdale N, Kadir A. Superior mesenteric artery and nutcracker syndromes in a healthy 14-year-old girl requiring surgical intervention after failed conservative management. Gastro Open J. 2020; 5(1): 1-3. doi: 10.17140/GOJ-5-132 ABSTRACT This case report presents the diagnosis of superior mesenteric artery and nutcracker syndromes in a previously fit and well 14-year- old girl. Although these two entities usually occur in isolation, despite their related aetiology, our patient was a rare example of their occurrence together. In this case the duodenal compression of superior mesenteric artery syndrome caused intractable vom- iting leading to weight loss, and her nutcracker syndrome caused severe left-sided abdominal pain and microscopic haematuria without renal compromise. Management of the superior mesenteric artery syndrome can be conservative by increasing the weight of the child which leads to improvement of retroperitoneal fat and hence the angle of the artery. -
Normal and Variant Origin and Branching Pattern of Inferior Phrenic Arteries and Their Clinical Implications: a Cadaveric Study
International Journal of Research in Medical Sciences Thamke S et al. Int J Res Med Sci. 2015 Jan;3(1):282-286 www.msjonline.org pISSN 2320-6071 | eISSN 2320-6012 DOI: 10.5455/2320-6012.ijrms20150151 Research Article Normal and variant origin and branching pattern of inferior phrenic arteries and their clinical implications: a cadaveric study Swati Thamke1*, Pooja Rani2 1Department of Anatomy, UCMS & GTB Hospital, Delhi, India 2Department of Anatomy, PGIMS, Rohtak, Haryana, India Received: 6 December 2014 Accepted: 18 December 2014 *Correspondence: Dr. Swati Thamke, E-mail: [email protected] Copyright: © the author(s), publisher and licensee Medip Academy. This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial License, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. ABSTRACT Background: Inferior phrenic arteries, which constitute the chief arterial supply to the diaphragm, are generally the branches of abdominal aorta, however, variations in their mode of origin is not uncommon. Very less information is available regarding the functional anatomy of the inferior phrenic artery in anatomy textbooks. Methods: The present study was conducted utilizing 36 formaline-fixed cadavers between 22 years to 80 years over a period of 5 years. The frequency and anatomical pattern of the origin of the right and left inferior phrenic arteries were studied. Results: On the right side, the inferior phrenic artery arose independently from abdominal aorta in 94.4% cases and on the left side in 97.2% cases.Other sources of origin were seen in 5.55% cases.