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D0mo00168f2.Pdf Electronic Supplementary Material (ESI) for Molecular Omics. This journal is © The Royal Society of Chemistry 2020 Supporting Information Temporal Gene Expression Profiling of Maslinic Acid-Treated Raji Cells Lau Wai Meng 2, Menaga Subramaniam1,2, Hoe Han Goh3, Lim Yang Mooi1,2* Affiliation 1Department of Pre-Clinical Science, Faculty of Medicine and Health Sciences, Universiti Tunku Abdul Rahman, Lot PT21144, Jalan Sungai Long, Bandar Sungai Long, 43000 Kajang, Selangor, Malaysia 2Centre for Cancer Research, Faculty of Medicine and Health Sciences, Universiti Tunku Abdul Rahman, PT21144, Jalan Sungai Long, Bandar Sungai Long, 43000 Kajang, Selangor, Malaysia 3Institute of Systems Biology, Universiti Kebangsaan Malaysia, UKM Bangi, Bangi, Malaysia Correspondence Prof. Dr. Lim Yang Mooi, Department of Pre-Clinical Science, Faculty of Medicine and Health Sciences, Universiti Tunku Abdul Rahman, Lot PT21144, Jalan Sungai Long, Bandar Sungai Long, 43000 Kajang, Malaysia. E-mail: [email protected] Phone: +60390194722 ex178 Fax: +603 90191959 Table 1S. Gene transcripts with a p-value of less than 0.05 and expression fold-change of ±2.0 across at least 2 time-points Transcripts Log of fold-change Cluster Id p-value 4 hours 8 hours 12 hours 24 hours 48 hours 7959354 1.3E-02 -1.3058 -1.5890 -1.4932 -1.1168 -1.2231 8014891 7.2E-05 -1.3041 -2.2011 -2.2267 -1.3784 -1.3169 8122334 8.4E-04 -1.0944 -2.1491 -2.2478 -2.3706 -2.1508 8104901 2.8E-05 -1.0246 -1.3624 -1.8409 -1.2404 -1.8301 7909350 1.7E-04 -1.0208 -2.2835 -2.5744 -2.2862 -2.5478 7930927 3.1E-04 1.0152 1.4537 1.3382 1.2873 1.8381 7951077 9.6E-06 1.0247 1.6745 1.8100 1.3330 1.3423 7988581 4.4E-04 1.0276 1.1814 1.1702 1.1542 1.3929 7908409 7.1E-04 1.0323 1.1883 1.4319 1.4055 2.1068 7908614 7.6E-07 1.0407 1.4709 1.3987 1.0743 1.0535 7927146 4.6E-04 1.0640 1.4369 1.4719 1.0494 1.0874 8088820 1.1E-03 1.0687 1.3088 1.3846 1.1836 1.4865 8040340 3.2E-05 1.1019 1.4510 2.1477 2.7407 2.4759 8179263 1.1E-05 1.1702 1.4956 1.8275 2.7438 1.8850 8177983 1.2E-05 1.1734 1.4809 1.8229 2.7416 1.8893 7996954 2.3E-05 1.1761 1.2036 1.2570 1.3251 1.4174 8118142 1.1E-05 1.1815 1.4929 1.8318 2.7499 1.8965 8147344 1.9E-08 1.1963 1.5263 1.7797 1.9956 2.1561 7915160 8.9E-05 1.2059 1.3131 1.2327 1.2788 1.4119 7904018 7.6E-05 1.2155 2.0938 2.0671 2.1181 1.8214 8024485 5.6E-02 1.2196 1.2194 1.1745 1.5050 1.1696 7962884 1.0E-02 1.2730 1.0901 1.4004 1.4768 1.7706 8166289 8.9E-04 1.3350 1.4318 1.3612 1.3056 1.2537 8031047 2.1E-03 1.3559 1.1944 1.0338 1.2570 1.4851 8052689 3.1E-03 1.4091 1.3231 1.2464 1.4387 1.4678 7907160 1.2E-05 1.5475 2.0191 2.3011 1.6774 1.8729 7906613 6.3E-05 1.6275 2.4251 1.9345 1.9318 2.9300 8083569 3.2E-05 1.6301 1.5426 1.5670 1.5690 1.5113 8116649 1.4E-05 1.6857 2.8524 3.1246 3.0647 2.5039 8116653 1.4E-05 1.6900 2.8487 3.1243 3.0666 2.5036 7933872 2.5E-04 2.0475 2.0246 2.5526 3.5423 2.8864 7960865 1.5E-05 2.1015 2.8649 3.2381 4.0654 4.0060 8015031 1.1E-03 3.0579 3.5709 3.0130 2.8479 3.1962 8108370 1.3E-06 3.6314 3.5677 3.6132 3.8088 2.9792 7927062 1.9E-05 -1.2275 -1.3620 -1.5099 -1.0674 -0.9927 8041168 4.0E-02 -1.0202 -1.1212 -1.0073 -1.2688 -0.6720 7953878 1.6E-07 -1.0930 -2.2492 -2.7129 -1.7638 -0.9400 7908125 1.7E-04 1.3396 1.5180 1.3334 1.1425 0.8911 7918955 9.2E-08 1.0480 1.4020 1.2554 1.0474 0.9836 8117106 2.6E-08 -1.1088 -1.7253 -1.9472 -1.6856 -1.9446 8100943 7.7E-07 -0.7896 -2.1996 -2.6043 -2.6395 -2.5490 8175393 5.3E-07 -0.3747 -0.8577 -1.3280 -1.2895 -2.2477 7982663 6.1E-10 -0.0854 -0.5596 -0.4801 -1.6292 -2.9746 8018860 3.2E-07 -0.6689 -0.9257 -0.7807 -2.2421 -3.2001 8078248 2.0E-08 -0.2464 -0.4250 -0.8206 -1.3919 -1.6425 8083941 2.5E-10 -0.0268 -0.0519 -0.1832 -1.1355 -1.9876 8014974 3.9E-08 -0.1200 -0.1248 -0.1948 -0.9552 -2.0126 8057744 2.3E-09 0.5770 1.1830 1.7541 4.9104 4.8168 7944560 2.4E-08 0.6334 1.5229 2.0268 2.2044 2.1930 8129677 9.3E-07 0.8994 1.2333 1.2141 2.0323 2.3453 7965040 1.1E-07 0.1908 0.7834 1.1813 1.9549 2.0961 8058295 1.5E-06 0.1931 0.9557 1.0421 1.0998 1.0722 8004184 3.7E-07 0.0716 -0.1633 0.1002 3.5089 4.5170 7926239 1.6E-06 0.0000 0.1916 0.5041 1.6559 2.0566 8051501 7.8E-07 0.1352 0.2378 0.3089 1.7894 1.9253 8061579 1.5E-09 0.0053 -0.1161 -0.2207 -0.9256 -1.8360 8014391 1.7E-06 -0.0370 -0.1682 0.5560 2.7342 2.6611 8014414 1.7E-06 -0.0348 -0.1665 0.5567 2.7352 2.6623 8019731 1.7E-06 -0.0367 -0.1686 0.5562 2.7349 2.6616 8048940 4.6E-07 0.4762 0.8810 0.9652 2.7610 2.6477 8094743 3.2E-07 -1.4982 -2.2729 -2.3872 -1.1540 -0.3131 7925257 8.4E-07 0.4533 1.0860 1.2175 1.3674 1.8281 7935270 5.4E-07 -0.4626 -1.8367 -2.1661 -2.1519 -2.4368 8167185 1.5E-07 0.1246 0.8698 2.1489 4.7711 3.6999 7902541 2.5E-08 0.0208 0.0704 -0.0347 4.3151 5.8758 7929438 1.6E-07 0.1358 -0.1307 -0.4583 -1.4382 -1.9724 7948656 1.4E-07 0.2203 0.6867 0.7639 1.5482 1.2536 8014391 1.7E-06 -0.0370 -0.1682 0.5560 2.7342 2.6611 8048940 4.6E-07 0.4762 0.8810 0.9652 2.7610 2.6477 8078248 2.0E-08 -0.2464 -0.4250 -0.8206 -1.3919 -1.6425 8160559 7.8E-07 0.3502 0.2017 0.5550 4.5512 4.5115 8047419 9.4E-05 0.4994 0.5532 0.4628 1.2683 0.9513 8148317 5.2E-05 -1.0751 -1.1458 -1.0459 -0.6846 -0.3767 8122202 2.6E-06 -0.5721 -1.2001 -1.0681 -1.6209 -1.3945 7957759 1.1E-05 1.4381 1.4266 1.3408 0.6126 0.4537 7998978 6.5E-06 1.6112 1.5211 1.0900 0.8915 0.7052 7939738 1.3E-03 -0.5987 -1.0704 -0.6623 -1.0457 -1.6239 8071768 1.1E-02 -0.7561 -1.3202 -1.1868 -1.1355 -1.4359 8102362 1.0E-04 -0.6179 -1.1522 -1.2796 -1.1553 -1.4037 8046488 4.2E-07 -0.8482 -1.1170 -1.2454 -1.4781 -2.0935 8141395 1.0E-03 -0.6054 -1.0230 -1.2083 -1.7418 -2.2386 8105111 6.4E-07 -0.7561 -1.4009 -1.4345 -1.2262 -1.0881 8102560 5.3E-09 -0.6326 -1.0105 -1.4780 -2.4141 -2.9416 7927710 3.3E-06 -0.6579 -1.0414 -1.2905 -2.0695 -2.3778 7953333 9.1E-05 -0.4264 -1.2110 -1.3532 -1.4325 -1.7086 8152133 5.0E-08 -0.6149 -1.0429 -1.2498 -1.4270 -1.7042 8097657 3.2E-06 -0.7701 -1.4898 -1.4043 -1.4733 -1.6915 8083000 2.3E-04 -0.7048 -1.4841 -1.5934 -1.4323 -1.4975 7987405 1.1E-03 -0.6739 -1.1130 -1.2172 -1.0905 -1.4739 8071768 1.1E-02 -0.7561 -1.3202 -1.1868 -1.1355 -1.4359 7987165 1.1E-05 -0.5586 -1.3212 -1.6631 -1.2515 -1.3582 8012257 2.5E-04 -0.3209 -1.0548 -1.5501 -1.2541 -1.2732 8130185 2.2E-03 -0.5732 -1.2544 -1.6972 -1.4133 -1.1080 8100943 7.7E-07 -0.7896 -2.1996 -2.6043 -2.6395 -2.5490 7953218 6.9E-09 -0.1282 -0.6652 -1.1388 -2.2978 -2.8934 8019842 1.8E-06 -0.4108 -0.9736 -1.5348 -2.4004 -2.8411 7989647 1.2E-06 -0.5421 -0.6348 -1.0929 -2.4489 -3.3447 7916727 1.6E-05 -0.7448 -0.8144 -1.0525 -1.6815 -2.3720 7921637 3.1E-08 -0.8731 -1.9191 -2.2623 -2.0049 -2.1046 8123819 3.5E-03 -0.5122 -0.7708 -1.1236 -1.0902 -1.2413 8036525 2.7E-04 -0.3360 -0.7325 -1.1346 -1.2427 -1.1127 7897561 9.6E-06 -0.0470 0.8005 1.2882 1.7365 1.1904 8072876 2.9E-06 -0.0404 0.2994 1.0236 3.0259 2.9024 8101126 2.3E-06 0.0634 -1.3244 -1.4286 3.9037 3.9387 7926368 7.4E-04 0.7245 1.4675 1.7079 2.0223 1.4529 7996022 1.1E-01 0.3144 1.1714 1.7169 2.2878 1.1461 8123609 9.3E-02 0.8245 1.2819 1.1952 1.3382 1.1472 7923453 1.9E-04 0.5649 1.0428 1.1688 1.6382 1.3068 7930413 3.7E-06 0.7292 1.0066 1.1215 1.5888 1.3924 8116559 1.1E-03 0.9232 1.4542 1.3360 1.8057 1.5229 8044919 2.2E-06 0.3288 1.1377 1.3967 1.7546 1.6271 7964460 1.5E-02 0.9288 1.1293 1.2847 2.1859 2.1261 8110569 2.1E-05 0.7429 1.7574 2.2124 2.6944 2.1557 8135069 5.7E-06 0.8109 1.9774 2.6069 3.1446 2.5471 7912145 5.4E-07 0.4058 1.4296 2.2460 3.7392 2.6622 8077376 3.7E-04 0.3261 0.7817 1.1708 1.2969 1.3849 7965040 1.1E-07 0.1908 0.7834 1.1813 1.9549 2.0961 7919095 1.7E-02 0.5472 0.7950 1.3635 1.3585 1.1819 8149733 3.1E-05 0.5844 0.7879 1.0616 1.4252 1.3752 7983969 6.4E-06 -0.0818 -0.1278 -0.4203 -1.6110 -3.0430 7968563 2.2E-06 -0.1887 -0.3334 -0.5442 -1.7486 -2.8154 7960340 2.2E-06 -0.3346 -0.5547 -0.9081 -1.7462 -2.5179 7942527 6.6E-06 -0.7878 -0.8187 -0.9609 -1.6748 -2.3180 8138489 2.5E-04 -0.5877 -0.8200 -0.7526 -1.6352 -1.7467 8097356 8.0E-09 -0.2087 -0.4348 -0.9856 -2.0110 -3.0093 7974404 1.9E-04 -0.1351 -0.2770 -0.3828 -1.1574 -2.7052 7909708 3.0E-05 -0.3078 -0.6166 -0.5842 -1.4681 -2.6783 8120838 1.1E-04 -0.3693 -0.3979 -0.5638 -1.3481 -2.5169 7945014 8.4E-09 -0.2863 -0.5425 -0.7455 -1.5079 -2.3527 7994109 2.3E-06 -0.2800 -0.6633 -0.6049 -1.1056 -2.1957 7982792 3.3E-06 -0.3081 -0.6401 -0.9347 -1.5927 -1.9324 8171381 5.8E-06 -0.3928 -0.0629 -0.4779 -1.1136 -1.5555 8063043 2.8E-04 -0.1485 -0.4331 -0.6164 -1.0519 -1.5000 8029136 6.2E-02 -0.2409 -0.5663 -0.7593 -1.0778 -1.4669 7978846 4.7E-04 -0.4617 -0.7168 -0.9420 -1.0728 -1.4569 7905826 4.7E-05 -0.1989 -0.9011 -0.7596 -1.5847 -1.3971 7904314 2.7E-03 -0.4720 -0.7221 -0.8652 -1.0632 -1.2611 7913869 6.6E-05 -0.2462 -0.2837 -0.4686 -1.1504 -1.2601 7914141 8.4E-05 -0.6874 -0.5029 -0.8277 -1.4739 -1.2224 8160647 8.7E-03 -0.0801 -0.3196 -0.5229 -1.0897 -1.1529 8020468 5.1E-06 -0.4603 -0.7175 -0.7287 -1.0698 -1.0756 8035847 4.5E-03 -0.3073 -0.3577 -0.9279 -1.1483 -1.0459 7938035 3.0E-05 -0.3846 -0.5040 -0.7468 1.6783 2.0330 8118571 4.6E-04 -0.7844 -0.6670 -0.4139 1.0334 1.0870 8179495 4.5E-04 -0.7886 -0.6745 -0.4126 1.0275 1.1026 8178211 4.7E-04 -0.7833 -0.6738 -0.4138 1.0326 1.1101 8073088 2.7E-06 -0.2517 -0.2827 -0.2744 1.5398 1.4836 8006608 4.0E-05 -0.4166 -0.9899 -0.7334 1.4491 1.6544 8040080 2.2E-04 -0.1108 -0.0303 -0.0535 2.7034 4.2293 8101118 7.4E-03 -0.1000 -0.0470 -0.0831 3.6285 4.4566 8137414 8.3E-05 -0.4487 -0.0904 0.2398 1.0235 1.1958 8048898 3.3E-06 -0.1869 -0.2439 0.1397 2.1292 2.5616 8014316 6.0E-04 -0.0030 -0.0580 0.3247 3.0167 4.1850 7982757 2.5E-04 -0.0711 0.0243 -0.1257 -1.2739 -2.0315 7902553 5.1E-08 -0.0258 0.0434 -0.0059 3.6807 4.8355 7914851 3.4E-05 -0.1926
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