Parenchymal-sparing Hepatectomy as the New Doctrine in the Treatment of Liver-metastatic Colorectal Disease: Beyond Oncological Outcomes. D. MORIS, D. DIMITROULIS, S. VERNADAKIS, A. PAPALAMPROS, E. SPARTALIS, A. PETROU, T.M. PAWLIK, E. FELEKOURAS (Cleveland; Columbus, OH, USA; Athens, Greece) ...... 9

Three Pathways of Colonic Carcinogenesis in Rats. C.A. RUBIO (Stockholm, Sweden) ...... 15

Advances in Experimental Targeted Therapy and Immunotherapy for Patients with Glioblastoma Multiforme. J. POLIVKA JR, J. POLIVKA, L. HOLUBEC, T. KUBIKOVA, V. PRIBAN, O. HES, K. PIVOVARCIKOVA, I. TRESKOVA (Plzen, Czech Republic) ...... 21

Histone Deacetylase Inhibitors: An Attractive Therapeutic Strategy Against Breast Cancer. C. DAMASKOS, S. VALSAMI, M. KONTOS, E. SPARTALIS, T. KALAMPOKAS, E. KALAMPOKAS, A. ATHANASIOU, D. MORIS, A. DASKALOPOULOU, S. DAVAKIS, G. TSOUROUFLIS, K. KONTZOGLOU, D. PERREA, N. NIKITEAS, D. DIMITROULIS (Athens, Greece; Aberdeen, UK; Cleveland, OH, USA) ...... 35 Experimental Studies KIF11 Is Required for Spheroid Formation by Oesophageal and Colorectal Cancer Cells. T. IMAI, N. OUE, K. SENTANI, N. SAKAMOTO, N. URAOKA, H. EGI, T. HINOI, H. OHDAN, K. YOSHIDA, W. YASUI (Hiroshima; Gifu; Kure, Japan) ...... 47 Contents continued on the back cover Contents continued

Comparison of Tumor Recurrence After Resection of Highly- and Poorly-Metastatic Triple-negative Breast Cancer in Orthotopic Nude-Mouse Models. S. YANO, K. TAKEHARA, H. KISHIMOTO, H. TAZAWA, Y. URATA, S. KAGAWA, T. FUJIWARA, M. BOUVET, R.M. HOFFMAN (San Diego, CA, USA; Okayama; Tokyo, Japan) ...... 57

Cervical Cancer Patient-Derived Orthotopic Xenograft (PDOX) Is Sensitive to Cisplatinum and Resistant to Nab-paclitaxel. T. MURAKAMI, T. MURATA, K. KAWAGUCHI, T. KIYUNA, K. IGARASHI, H.K. HWANG, Y. HIROSHIMA, C. HOZUMI, S. KOMATSU, T. KIKUCHI, T.M. LWIN, J.C. DELONG, K. MIYAKE, Y. ZHANG, K. TANAKA, M. BOUVET, I. ENDO, R.M. HOFFMAN (San Diego, CA, USA; Yokohama; Okayama; Sendai; Okinawa; Ishikawa; Tokyo, Japan; Seoul, Republic of Korea) ...... 61

A Novel NHERF1 Mutation in Human Breast Cancer and Effects on Malignant Progression. X. YANG, G. DU, Z. YU, Y. SI, T.A. MARTIN, J. HE, S. CHENG, W.G. JIANG (Beijing, PR China; Heath Park, Cardiff, UK) ...... 67

YM155 Reverses Statin Resistance in Renal Cancer by Reducing Expression of Survivin. T. NITTA, H. KOIKE, T. MIYAO, Y. MIYAZAWA, H. KATO, Y. FURUYA, Y. SEKINE, K. SUZUKI (Maebashi, Japan) ...... 75

Long Noncoding RNA PANDA Positively Regulates Proliferation of Osteosarcoma Cells. Y. KOTAKE, T. GOTO, M. NAEMURA, Y. INOUE, H. OKAMOTO, K. TAHARA (Iizuka, Japan) ...... 81

Validation of VX2 as a Hepatocellular Carcinoma Model: Comparison of the Molecular Reaction of VX2 and HepG2 Tumor Cells to Sorafenib In Vitro . N. NASS, S. STREIT, C. WYBRANSKI, J. JÜRGENS, J. BRAUNER, N. SCHULZ, M. POWERSKI, J. RICKE, T. KALINSKI, O. DUDECK, M. SEIDENSTICKER (Magdeburg; Cologne, Germany; Zurich, Switzerland) ...... 87

The Effects of Petroselinum Crispum on Estrogen Receptor-positive Benign and Malignant Mammary Cells (MCF12A/MCF7). L. SCHRÖDER, J. KOCH, S. MAHNER, B.P. KOST, S. HOFMANN, U. JESCHKE, J. HAUMANN, J. SCHMEDT, D.U. RICHTER (Munich; Rostock, Germany) ...... 95

Synergistically Anti-metastatic Effect of 5-Flourouracil on Colorectal Cancer Cells via Calcium-mediated Focal Adhesion Kinase Proteolysis. M. PARK, P. SUNDARAMOORTHY, J.J. SIM, K.-Y. JEONG, H.M. KIM (Incheon, Republic of Korea) ...... 103

Metformin Exerts Antiproliferative and Anti-metastatic Effects Against Cholangiocarcinoma Cells by Targeting STAT3 and NF-ĸB. C. SAENGBOONMEE, W. SEUBWAI, U. CHA’ON, K. SAWANYAWISUTH, S. WONGKHAM, C. WONGKHAM (Khon Kaen, Thailand) ...... 115

Galectin-3 Is Implicated in Tumor Progression and Resistance to Anti-androgen Drug Through Regulation of Androgen Receptor Signaling in Prostate Cancer. T.-O. DONDOO, T. FUKUMORI, K. DAIZUMOTO, T. FUKAWA, M. KOHZUKI, M. KOWADA, Y. KUSUHARA, H. MORI, H. NAKATSUJI, M. TAKAHASHI, H.-O. KANAYAMA (Tokushima, Japan) ...... 125

Clinicopathological Implication of Insulin-like Growth Factor-II mRNA-Binding Protein 3 (IMP3) Expression in Gastric Cancer. D. LEE, E.J. YU, I.-H. HAM, H. HUR (Suwon, Republic of Korea) ...... 135

Potential Prognostic Molecular Signatures in a Preclinical Model of Melanoma. S.P. FORTIS, E.A. ANASTASOPOULOU, I.F. VOUTSAS, C.N. BAXEVANIS, S.A. PEREZ, L.G. MAHAIRA (Athens, Greece) ...... 143

Synergistic Cytotoxicity of Melatonin and New-generation Anticancer Drugs Against Leukemia Lymphocytes but not Normal Lymphocytes. Z. ZHELEV, D. IVANOVA, R. BAKALOVA, I. AOKI, T. HIGASHI (Stara Zagora; Sofia, Bulgaria; Chiba, Japan) ...... 149 Contents continued on the preceding page Contents continued

Hyperforin Inhibits Cell Growth by Inducing Intrinsic and Extrinsic Apoptotic Pathways in Hepatocellular Carcinoma Cells. I.-T. CHIANG, W.-T. CHEN, C.-W. TSENG, Y.-C. CHEN, Y.-C. KUO, B.-J. CHEN, M.- C. WENG, H.-J. LIN, W.-S. WANG (Yilan; Taichung; Kaohsiung; Chia-Yi; Changhua; Taoyuan; Taipei; New Taipei, Taiwan, ROC) ...... 161 Clinical Studies

Detection of Circulating Tumour Cells and Survival of Patients with Non-Small Cell Lung Cancer. D. CHUDASAMA, J. BARR, J. BEESON, E. BEDDOW, N. MCGONIGLE, A. RICE, A. NICHOLSON, V. ANIKIN (London, UK) ...... 169

Different Expression Patterns of CXCR4, CCR7, Maspin and FOXP3 in Luminal Breast Cancers and Their Sentinel Node Metastases. L. STRIEN, K. JOENSUU, P. HEIKKILÄ, M.H. LEIDENIUS (Helsinki, Finland) ..... 175 + Prognostic Impact of CD163 Macrophages in Tumor Stroma and CD8+ T-Cells in Cancer Cell Nests in Invasive Extrahepatic Bile Duct Cancer. T. MIURA, T. YOSHIZAWA, H. HIRAI, H. SEINO, S. MOROHASHI, Y. WU, T. WAKIYA, N. KIMURA, D. KUDO, K. ISHIDO, Y. TOYOKI, H. KIJIMA, K. HAKAMADA (Hirosaki, Japan) ...... 183

Low Expression of FBXO45 Is Associated with Gastric Cancer Progression and Poor Prognosis. N. KOGURE, T. YOKOBORI, K. OGATA, B. ALTAN, E. MOCHIKI, T. OHNO, Y. TOYOMASU, M. YANAI, A. KIMURA, T. YANOMA, M. SUZUKI, T. BAI, T. ASAO, H. KUWANO (Maebashi; Saitama, Japan) .... 191

Gender Difference in Distribution of Estrogen and Androgen Receptors in Intestinal-type Gastric Cancer. Z. JUKIC, P. RADULOVIC, R. STOJKOVIĆ, A. MIJIC, J. GRAH, B. KRUSLIN, Z. FERENCIC, A. FUCIC (Nova Gradiska; Zagreb; Osijek, Croatia) ...... 197

Survival Following Palliative External-beam Radiotherapy of Locally Advanced and Metastatic Liver Cancer. D. RADES, L. BOLM, S.E. SCHILD, T. BARTSCHT (Lübeck, Germany; Scottsdale, AZ, USA) ...... 203

Podoplanin Expression in Cancer-associated Fibroblasts Predicts Poor Prognosis in Patients with Squamous Cell Carcinoma of the Lung. Y. YURUGI, M. WAKAHARA, Y. MATSUOKA, T. SAKABE, Y. KUBOUCHI, T. HARUKI, K. NOSAKA, K. MIWA, K. ARAKI, Y. TANIGUCHI, T. SHIOMI, H. NAKAMURA, Y. UMEKITA (Tottori, Japan) ...... 207 mMRI at 3.0 T as an Evaluation Tool of Therapeutic Response to Neoadjuvant CRT in Patients with Advanced- stage Rectal Cancer. U.I. ATTENBERGER, M.M. ONG, N. RATHMANN, F. DOYON, P. KIENLE, R.-D. HOFHEINZ, L.R. PILZ, D.J. DINTER, S.O. SCHOENBERG, D. HAUSMANN (Mannheim, Germany) ...... 215

Granulocyte Colony-stimulating Factor Producing Anaplastic Carcinoma of the Pancreas: Case Report and Review of the Literature. S. VINZENS, J. ZINDEL, M. ZWEIFEL, T. RAU, B. GLOOR, A. WOCHNER (Bern, Switzerland) ...... 223

Identification and Management of Head and Neck Cancer Recurrences Detected on Adjuvant Radiation Oncology Simulation Scans. R.L. BAKST, W. SU (New York, NY, USA) ...... 229

Gemcitabine and S-1 Induction Chemotherapy Followed by Chemoradiotherapy for Locally Advanced Pancreatic Cancers. K. MAEMURA, Y. MATAKI, H. KURAHARA, Y. KAWASAKI, S. IINO, M. SAKODA, Y. UCHIKADO, T. ARIGAMI, Y. UENOSONO, S. MORI, S. UENO, H. SHINCHI, S. NATSUGOE (Kagoshima, Japan) ...... 233

Metastatic Pattern of Stage IV Colorectal Cancer with High-Frequency Microsatellite Instability as a Prognostic Factor. K. FUJIYOSHI, G. YAMAMOTO, T. TAKENOYA, A. TAKAHASHI, Y. ARAI, M. YAMADA, M. KAKUTA, K. YAMAGUCHI, Y. AKAGI, Y. NISHIMURA, H. SAKAMOTO, K. AKAGI (Saitama; Fukuoka; Tokyo, Japan) ...... 239 Contents continued on the preceding page Contents continued

Development of a Survival Score for Patients with Cerebral Metastases from Melanoma. L. SEHMISCH, S.E. SCHILD, D. RADES (Scottsdale, AZ, USA) ...... 249

A Study of Angiogenesis Markers in Patients with Renal Cell Carcinoma Undergoing Therapy with Sunitinib. C. STUBBS, A.D. BARDOLI, M. AFSHAR, S. PIRRIE, M. MISCORIA, I. WHEELEY, E. PORFIRI (Birmingham; Coventry, UK) ...... 253

Laparoscopic versus Open Partial Nephrectomy: Comparison of Overall and Subgroup Outcomes. M. ABDELHAFEZ, A. BASTIAN, S. RAUSCH, A. STENZL, J. BEDKE, S. KRUCK (Tuebingen, Germany; Assiut, Egypt) ...... 261

Objective Predictive Score as a Feasible Biomarker for Short-term Survival in TerminalIy Ill Patients with Cancer. Y. OKUGAWA, Y. SHIRAI, H. NODONO, F. MATSUTANI, M. ITOH, A. HISHIDA, Y. MORIMOTO, R. NISHIKAWA, T. YOKOE, K. TANAKA, H. URATA, Y. TOIYAMA, T. ARAKI, Y. INOUE, M. TANAKA, M. KUSUNOKI, C. MIKI (Mie; Nagoya, Japan) ...... 267

Surgical Resection of Giant Pheochromocytomas Arising Behind the Retrohepatic Inferior Vena Cava. Y. SOEJIMA, T. YOSHIZUMI, T. IKEGAMI, N. HARIMOTO, S. ITO, N. HARADA, T. MOTOMURA, A. NAGATSU, T. IKEDA, Y. MAEHARA (Fukuoka, Japan) ...... 277

Prognostic and Therapeutic Potential Implications of Genetic Variability in Prostaglandin E2 Pathway Genes in Rectal Cancer. M.D. SANTOS, C. SILVA, A. ROCHA, C. NOGUEIRA, F. CASTRO- POÇAS, A. ARAUJO, E. MATOS, C. PEREIRA, R. MEDEIROS, C. LOPES (Porto, Portugal) ...... 281

Association of Inflammasome Components in Background Liver with Poor Prognosis After Curatively- resected Hepatocellular Carcinoma. F. SONOHARA, Y. INOKAWA, M. KANDA, Y. NISHIKAWA, S. YAMADA, T. FUJII, H. SUGIMOTO, Y. KODERA, S. NOMOTO (Nagoya, Japan) ...... 293

Distant Bystander Effect of REIC/DKK3 Gene Therapy Through Immune System Stimulation in Thoracic Malignancies. K. SUZAWA, K. SHIEN, H. PENG, M. SAKAGUCHI, M. WATANABE, S. HASHIDA, Y. MAKI, H. YAMAMOTO, S. TOMIDA, J. SOH, H. ASANO, K. TSUKUDA, Y. NASU, H. KUMON, S. MIYOSHI, S. TOYOOKA (Okayama, Japan) ...... 301

Platinum-based Doublet Chemotherapy for Advanced Gastric Cancer with Disseminated Intravascular Coagulation. K. SUGIYAMA, Y. NARITA, S. KADOWAKI, T. URA, M. TAJIKA, K. MURO (Aichi, Japan) ...... 309

Stereotactic Body Radiotherapy in Patients with Lung Oligometastases from Colorectal Cancer. F. PASQUALETTI, S. MONTRONE, C. VIVALDI, M. ZANI, D. FEDELE, L. FORNARO, G. PASQUALETTI, L. SALVATORE, B. MANFREDI, C. LALISCIA, G. CORAGGIO, A. GONNELLI, F. LOUPAKIS, G. MASI, A. SAINATO, F. MONZANI, A. FALCONE, F. PAIAR (Pisa, Italy) ...... 315

Technical Feasibility and Oncological Legitimacy of Enucleation of Intraductal Papillary Mucinous Neoplasm Located at the Pancreatic Head or Uncinate Process. Y. SOEJIMA, T. TOSHIMA, T. MOTOMURA, T. YOKOTA, K. JOKO, Y. OSHIRO, I. TAKAHASHI, T. NISHIZAKI, Y. MAEHARA (Fukuoka; Ehime, Japan) ...... 321

Clinical Impact of Escalating Relative High-dose-rate Intracavitary Brachytherapy Dose in Stage IIB Cervical Cancer. O. CHO, O.K. NOH, Y.-T. OH, S.-J. CHANG, M. CHUN (Suwon, Republic of Korea) ...... 327

Minimally Invasive Lymphadenectomy in Uterine Cervical Cancer: A Systematic Review. N. RIZOU, D. MORIS, E. PIKOULIS, N. DIMITROKALLIS, E. MPAILI, E. FELEKOURAS, A. PAPALAMPROS (Athens, Greece; Cleveland, OH, USA) ...... 335 Contents continued on the preceding page Contents continued

Double Endoscopic Intraluminal Operation (DEILO) for Early Gastric Cancer: Outcome of Novel Procedure for Endoscopic Submucosal Dissection. K. OGATA, M. YANAI, K. KURIYAMA, M. SUZUKI, T. YANOMA, A. KIMURA, N. KOGURE, Y. TOYOMASU, T. OHNO, E. MOCHIKI, H. KUWANO (Maebashi; Chichibu; Kawagoe, Japan) ...... 343

Tumescent Anesthesia in Skin- and Nipple-sparing Mastectomy: Results of a Prospective Clinical Study. M. GIPPONI, I. BALDELLI, G. ATZORI, P. FREGATTI, F. MURELLI, M. PESCE, C. MARGARINO, F. DEPAOLI, D. FRIEDMAN (Genoa, Italy) ...... 349

Clinical Performance of CEA, CA19-9, CA15-3, CA125 and AFP in Gastrointestinal Cancer Using LOCI™- based Assays. R.C. DOLSCHEID-POMMERICH, S. MANEKELLER, G. WALGENBACH-BRÜNAGEL, J.C. KALFF, G. HARTMANN, B.S. WAGNER, S. HOLDENRIEDER (Köln; Bonn, Germany) ...... 353

Book Reviews ...... 361

Announcements ...... 375

Table of Contents