1 Vojnosanitetski Pregled Vojnomedicinska Akademija
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VOJNOSANITETSKI PREGLED VOJNOMEDICINSKA AKADEMIJA Crnotravska 17, 11 000 Beograd, Srbija Tel/faks: +381 11 2669689 [email protected] ACCEPTED MANUSCRIPT Accepted manuscripts are the articles in press that have been peer reviewed and accepted for publication by the Editorial Board of the Vojnosanitetski Pregled. They have not yet been copy edited and/or formatted in the publication house style, and the text could still be changed before final publication. Although accepted manuscripts do not yet have all bibliographic details available, they can already be cited using the year of online publication and the DOI, as follows: article title, the author(s), publication (year), the DOI. Please cite this article MEDICINE IN THE HIPPOCRATIC AND POST- HIPPOCRATIC AGE Authors Tatjana Lazarevic||, Zoran Kovacevic*, Mirjana A. Janicijevic Petrovic‡, Biljana Ljujic**, Milos Glisic§ and Katarina Janicijevic†, Vojnosanitetski pregled (2021); Online First May, 2021. UDC: DOI: https://doi.org/10.2298/VSP210325057L When the final article is assigned to volumes/issues of the Journal, the Article in Press version will be removed and the final version appear in the associated published volumes/issues of the Journal. The date the article was made available online first will be carried over. 1 HISTORY OF MEDICINE MEDICINE IN THE HIPPOCRATIC AND POST-HIPPOCRATIC AGE Tatjana Lazarevic||, Zoran Kovacevic*, Mirjana A. Janicijevic Petrovic‡, Biljana Ljujic**, Milos Glisic§ and Katarina Janicijevic† ||Department of Internal medicine, Faculty of Medical Sciences University of Kragujevac, Serbia *Department of Internal medicine, Clinical Centre of Kragujevac, Kragujevac, Serbia ‡Department of Ophthalmology, Faculty of Medical Sciences University of Kragujevac, Serbia **Department of Genetic, Faculty of Medical Sciences University of Kragujevac, Serbia §Department of Physiology, Faculty of Medical Sciences University of Kragujevac, Serbia †Department of Social medicine, Faculty of Medical Sciences University of Kragujevac, Serbia †Corresponding author: †Katarina Janicijevic, Ass. Department of Social medicine, Faculty of Medical Sciences University of Kragujevac, Serbia Svetozara Markovica 69, 34000 Kragujevac, Serbia E-mail: [email protected] Tel: +381 64 2183797 Fax: +381 34 306 800 2 Introduction From the historical aspect, medicine is divided into pre-Hippocratic, Hippocratic and post- Hippocratic. Hippocratic medicine represents a period in which medicine developed under the influence of Hippocrates. The Hippocratic period includes the time when he lived, but also several centuries later. People who studied and practiced medicine according to his doctrine formed a kind of direction in medicine called Hippocratic. It is not possible to precisely define the date range of the actuality of Hippocratic medicine, but its influence on medicine today is realistically immeasurable 1. Hippocrates was a Greek physician, who lived from 460 to 377 BC, and who belonged to the period of the highest scope of the classical Hellenic science of medicine. His father was Heraclid. He worked within the medical school in Kos. He traveled extensively and died in Thessaly 1, Fig. 1. Figure 1. Hippocrates Hippocrates was the first to separate medicine from superstition, which was a kind of turning point in medicine, and he became a legend of medicine. The name "father of medicine" rightly belongs to him, because it represents the prototype and ethical ideal of the doctor, who spoke about human life and the doctor's attitude towards the patient. He influenced medical practice centuries in advance. He put the patient at the center of the treatment process, and the patient's well-being, that is, the welfare of the patient, as a priority in treatment. He believed that man was a part of nature and that diseases were a natural phenomenon, and in accordance with that, they were treated with natural methods. He believed that a man was treated, not a disease. He was the first doctor to ask a person how he/she felt. There are a lot of valid terms and methods of treatment that he left us. He was the originator of the concept of humoral medicine, which marked the diagnosis and understanding of pathology until the end of the New Century. He individualized medical therapy. He was a pioneer of medical propaedevtic. With him began what we call medical ethics. He practiced surgery, orthopedics, pharmacology, diet therapy and philosophy 1. Hippocrates's aphorism is well known: "Human life is short, medical skill is enormous; a favorable moment passes quickly; experience is deceptive, making a decision is difficult" 1. After Hippocrates, medicine was marked by the Dogmatic and Alexandrian schools. The most valuable representatives of the Dogmatic school were Diocletian and Praxagoras. The Alexandrian school was marked by Herophilos and Erasistratus. Aristotle made a great 3 contribution to medicine in this period 1, 2. Another physician who marked the Hippocratic period was Galen. Galen was a Roman physician who is claimed to have lived between 125 and 215 AD. His life expectancy is almost three times longer than expected in the Old Century, which raises doubts about the reliability of this information. Like Hippocrates, Galen developed the idea of humoral medicine, which practically meant that human health was defined by body fluids. Galen influenced medicine so much that his name bears not only the vein, but also the methods of preparing medicines in the pharmacy, and the prepared medicines are called Galena preparations. His teaching was considered a dogma for a period of 15 centuries 1, 2. Roman medicine did not leave anything original on its own, except for a few personal discoveries. It was mainly about elaborating the ideas and methods of Greek medicine. Notable Roman physicians in this period were Themison, Soranus, and Celsus 1, 2. It is important that the doctors of that time had open access to museums and other selections of archeological discoveries. The concept of pathogenic factors varied depending on the cultural context and historical period. In this sense, subdisciplines developed, such as paleopathology. Old methods and treatments that we neglected and overlooked may prove useful. Modern medicine should take into account past experiences in treatment, at least as a basis for research 3. Ancient Greek medicine of the Hippocratic period Greek medicine was a turning point in human treatment. The ancient Greeks separated medicine from superstition and divine manipulations and turned it towards a naturalistic concept (Truumees, 2015). This opened the way for the development of scientific medicine, and already in the 5th century BC, Greek doctors had their own association. There were permanent doctors (demiurges) and traveling doctors (periodeuts). Demiurges performed interventions in surgeries, where patients sometimes stayed in recovery, and without charge. The concept of hospitals did not exist at the time, but it can be said that this was its beginning. Periodeuts went to places where there were no doctors and charged according to the agreement. In treatment, they used herbs, examination, observation, surgery, and not prayer and spells. Nevertheless, Hippocrates made medicine a science 1, 2, 3. The most famous schools of medicine were in Kos, Kroton, Cnidus and Alexandria 1, 4. Nemesius was the first to theorize about the division of the brain in the 4th century BC. He believed that feelings and imagination were located in two lateral chambers in the frontal lobe of 4 the brain, and he called it the first cell. The mind was the function of the second cell, and in the posterior part of the brain was the third cell, which was in charge of remembering 5. Chrysippus of Soli, who lived between 279 and 206 BC, was the first to mention cataract surgery 6. Theophrastus is considered the father of botany. He wrote Decausisplantarum and Dehistoriaplantarum, important collections of herbal medicines 7. Hippocratic teaching He claimed that man was nature and a part of nature. So the disease had natural causes. He believed that climate, atmosphere, pollution, miasmatic fumes, food, colds and other external influences significantly affected human health. He assessed the signs and symptoms by following human feelings, as well as objective factors. He adjusted the therapy to the patient. A significant part of his treatment was diet therapy. Many aspects of which medicine is proud today, we really owe to him. The saying "Let your food be your medicine" is attributed to him 1, 7. He viewed man as a being who functioned in harmony with his environment. A person was treated as a complete being and everything related to his external and internal interactions was seen as a factor of illness. Therefore, Hippocrates is considered the originator of the concept of holistic medicine. Today, holistic medicine is seen as the ideological forerunner of complementary medicine 1, 7. He laid important foundations of medical ethics 1, 7. Hippocrates did not distinguish veins and arteries. All blood vessels were called phlebes, hollow tubes. He understood the brain in the same way as Alcmaeon: its function was to analyze information from the outside world, which created our thoughts and feelings1, 7. By the term neura he meant fibers such as veins, nerves, tendons, ligaments, and he believed that there were also hollow neurons such as pores, which could be opened to enter fluid if necessary. He claimed that the compression of the leg caused pallor, or blue discoloration of the extremities. He described how a carotid artery injury caused contralateral hemiplegia. He introduced inspection, palpation and the primitive variant of auscultation 4 - 7. Hippocratic humoral medicine Hippocrates based his teaching on Empedocles's idea of four elements: water, fire, air and earth. Thus, humans were a phenomenon, a consequence of the activity of four fluids: blood, phlegm, yellow and black bile. These liquids had four properties: hot, cold, dry and wet. He 5 believed that these aspects were governed by the force of physis. All harmful liquids tended to be expelled from the body after cooking (pepsis), which gave a fever.