The National Cancer Institute

Ft. Detrick’s 60th Anniversary story on page 3. News from the NCI-Frederick NOVEMBER 2003 Offi ce of Scientifi c Operations IN THIS ISSUE

This year we celebrate the 60th Owned-Contractor Operated (GOCO) Ft. Detrick’s 60th Anniversary 3 anniversary of Fort (Ft.) Detrick. facility. Ft. Detrick’s roots can be traced to The fi rst employees of the NCI- Major Construction Projects 4 a small municipal airport known as Frederick (then known as the Detrick Field1, The Field was named Frederick Cancer Research Center) Update 5 to honor Major Frederick L. Detrick, appeared on campus in June 1972 and who served in France during World numbered around 20 by the end of Scientifi c Publications, War I. The fi rst military presence at that month. By 1976 these numbers Graphics & Media News 6 the airfi eld was in 1931 when the had grown to about 750 individuals, National Guard established and by 1987 the staff numbered over Awards 6 a cadet pilot training center at Detrick 1,400 with a budget of nearly $100 Field and subsequently Platinum Publications 8 changed the name to Camp Detrick. Poster-Script 11 As we pause to think about the history of Ft. Did You Know? 12 Detrick and the many contributions that the Transfer Technology Branch 14 staff of Ft. Detrick has made in the areas of Community Outreach 15 infectious disease and national defense, it Offi ce of Diversity and seems that now is an Employee Programs 16 appropriate time to also look back at the history Environment, Health, and Safety of the NCI here at Ft. Program 18 Detrick. On November 25, 1969, then- Charles River Laboratories 19 President renounced million per year. Today, NCI-Frederick the further development and use of is the largest biomedical research Data Management Services 19 by the United organization in Frederick County, with States2. As a consequence of this nearly 3,000 employees, in over 100 SAIC-Frederick, Inc. 21 policy, the Army’s Biological Defense buildings totaling 1.3 million square Research Laboratory at Ft. Detrick feet, and with a budget of over $300 Wilson Information Services was disbanded, resulting in many open million per year. Corporation 22 labs on the Ft. Detrick campus. On What a long way we have come October 18, 1971, President Nixon since the days of Camp Detrick. But Job Vacancies 24 announced that these laboratories as we think about the history of NCI- would be used to develop one of the Frederick, we should also keep in nation’s leading centers for cancer mind the daunting journey ahead. research, functioning as a Government continued on page 2 News from the NCI-Frederick Offi ce of Scientifi c Operations continued from page 1 These startling statistics on cancer Yes, we have come a long way, but and AIDS exemplify the importance there is still much to do. One note and urgency of our work: of comfort: I can’t think of a more dedicated and capable group of people ● 1.3 million new cases of cancer to tackle these problems. Keep up the are expected this year in the good work! U.S. alone. ● Over 500,000 people in the U.S. will die this year from cancer. Craig Reynolds, ● In 2003 more than 3,400 new Director of cases and 1,400 deaths from the Offi ce of Scientifi c Operations cancer are expected in Frederick County alone. ● Presently, nearly 42,000,000 people worldwide are infected with the AIDS . ● By the time the AIDS epidemic is over, it will have been the most devastating epidemic in the history 1 2002 Post Guide and Telephone Directory. of the world. 2 Glassman HN. “The Frederick Cancer Research Center.” ASM News 42(10):603, 1976. Ø

NCI-Frederick Emergency Preparedness Committee

The NCI-Frederick Emergency You may have also seen the recent audio notifi cations to alert you when Preparedness Committee strives to e-mail messages from our testing messages arrive from the ENS. ensure that employees are informed, of the Emergency Notifi cation Your Emergency Preparedness aware, and prepared should emergency System (ENS). The ENS can quickly Committee is determined to help situations arise. Recently, the send e-mail messages throughout establish a community of informed, committee launched two programs NCI-Frederick to communicate aware, and prepared employees at aimed at communicating preparedness crucial information to the campus NCI-Frederick. We will continue to information to the community. community. In the coming weeks the keep you informed about these efforts This past summer the committee committee will add instructions to the through memorandums, e-mail, our launched the NCI-Frederick Emergency Preparedness Web site to Web site, and (of course) upcoming Emergency Preparedness Web site show you how to add “pop-up” and issues of The Poster. Ø (http://www.ncifcrf.gov/campus/ emergency). This Web site serves as a central point of information concerning emergency preparedness Important Phone Numbers and security awareness issues at NCI-Frederick. The site includes Protective Services...... 1091 important phone numbers, links to Occupational Health Services...... 1096 reference material and guidelines, Fire ...... 1410 and recent news. In the event of an Medical Emergency ...... 911 emergency, this site will also provide timely information and instructions for employees.

The NCI-Frederick Poster 2 November 2003 Fort Detrick’s 60th Anniversary

Five NCI/NIH Employees recruit and worked as a laboratory continuing presence as a leader in Among Those Honored at assistant in the biological program. biomedical research. Representative Ft. Detrick Forum Among the tens of thousands who DeLay commented that Fort Detrick have worked at Fort Detrick over its comprises “Good men and women At a recent symposium focusing 60-year history, she alone has shared serving for the dignity of mankind on Fort Detrick’s 60th anniversary, each day of that history. Ms. Herring … fi ghting against evil. That is Representative Roscoe Bartlett (R- is still faithfully serving in the tissue the defi nition of Fort Detrick and MD) recognized Mr. Orley Bourland, culture laboratory of the National I think the defi nition of heroism.” Mr. Ron Defelice, Dr. Henry Hearn, Cancer Institute at Frederick. Dr. Fauci pointed out that NIAID Ms. Ruth Herring, and Dr. Robert Dr. Robert McKinney came to plans to partner with USAMRIID in McKinney, among 40 employees Fort Detrick in 1960, to develop research. representing the many NCI, NIH, and vaccines for viral diseases. He and The forum took place at the Knott Fort Detrick employees who have his colleagues vaccinated countless Arena, Mount St. Mary’s College, made “extraordinary contributions to horses, saving South American and Emmitsburg, on October 4. biomedical research advances against American livestock industries from The 229th Maryland Army National many of the world’s deadly infectious disastrous loss due to Venezuelan Guard Band played marches, and diseases and ” at Fort Detrick equine encephalitis. Dr. McKinney soloist Viola Whielden provided in the past 60 years. Fort Detrick is a also served as project offi cer for the musical entertainment, while a local unique facility, hosting partnerships construction of what is former radio announcer, Tommy between military and civilian agencies now USAMRIID. In 1980, he became Grunwell, acted as emcee for such as NCI. Chief of Occupational Health and the event. Ø Orley Bourland supervised the safe Safety for the National Institutes of production of agents such as Health. Now retired, he is frequently in the nation’s fi rst pilot plant. When called upon for his experience production ended, he directed the and guidance. building’s decontamination. In 1972, Dr. Jan Paulsen, President of the Mr. Bourland joined the National Seventh Day Adventist World Church, Cancer Institute and contributed to offered an opening prayer at the the nation’s war on cancer until his recognition ceremony. Speakers at the retirement in 1988. event included Dr. Anthony Fauci, Ron Defelice began his Fort Detrick Director of the National Institute of career in 1963. As a contracting offi cer Allergy and Infectious for the Army, then for NIH, and later Diseases; keynote speaker for NCI-Frederick, over the next Congressman Tom DeLay 40 years he ensured that billions of (R-TX), Majority Leader taxpayers’ research and development of the US House of dollars went where they would bring Representatives; and Major the most value in the fi ght against General Lester Martinez- infectious diseases and cancer. Lopez, US Army Medical Dr. Henry Hearn was Chief Research and Materiel of Experimental Biology and of Command. Dr. Robert Microbiology for the Army. At Wiltrout, Associate Director NCI-Frederick from 1972 until for NCI-Frederick, represented his retirement in 1990, Dr. Hearn Dr. Andrew von Eschenbach, NCI oversaw scientifi c research contracts. Director. To this day, he continues to serve According to an article in the as an essential member of the Frederick News-Post (The News-Post, National Cancer Institute’s Biosafety Sunday, Oct. 5, 2003, A-5) Major Committee. General Lester Martinez-Lopez, US Ruth Herring arrived at Camp Army Medical Research and Materiel Detrick in 1943 as a young Army Command, spoke about Detrick’s

The NCI-Frederick Poster 3 November 2003 Major Construction Projects

Major Construction Projects Will Cause Traffi c Delays Street Main Gate and will permit Through the Main Gate Fort Detrick Security to divert traffi c to a lane inside the gate to conduct The Fort Detrick Master Planner’s dry cleaning, tailor shop, barber and searches and checks. Offi ce announced that the fi rst of beauty shop, food facility with drive- To help alleviate delays or several new major construction thru, and a canopy-covered gasoline congestion at the Main Gate area, projects along some of Fort Detrick’s sales area. it is recommended that individuals main traffi c arteries is scheduled to Construction of the mall will mean with decaled vehicles use one of the begin within the next few weeks. that heavy equipment and trucks post’s two other entrances at Old Farm Individuals with decaled vehicles will have to use the Seventh Street Gate off Rosemont Avenue and the who are currently using the front gate Main Gate to access the area. Expect Opossumtown Pike entrance. as their primary point of entry onto delays and slower than usual traffi c the fort may want to consider using fl ow through the front gate area while Other New either the Opossumtown Pike Gate construction is proceeding. Construction Projects or the Old Farm While a groundbreaking Gate off Rosemont date has not been offi cially Avenue instead. set, construction of a new Both gates are Commissary, on Porter Street open from 6 a.m. across from the new mini- to 6 p.m. Monday mall, is expected to begin through Friday, sometime next year. while the Seventh Funding has also been Street Gate is open approved for the renovation 24 hours a day. of the post’s Fire Station. The construction The renovation, which will projects, one of also occur later this year, which includes the will provide more storage reconfi guration of space and easier access the Main Gate, will to equipment. impact the local Other approved traffi c fl ow for the construction projects next several years. currently scheduled to Details of begin within the next two the upcoming construction and Main Gate Renovation years include a project to build 165 renovation projects were outlined in a Current security requirements dictate family homes for offi cers and enlisted presentation by U.S. Army Garrison that automobiles without decals can personnel, the construction of three Commander Ball to a group gain access to the fort only through new barracks and a dining facility, of Frederick County residents at a the Seventh Street Main Gate and and a new state-of-the-art research September 22nd public meeting at only after adequate identifi cation has facility for the U.S. Army, the National Strough Auditorium. The projects been provided. The resulting traffi c Institute of Allergy and Infectious under development include: delays and backups at the front gate Diseases and NCI-Frederick. have been a long-term problem for The current Fort Detrick Master Plan Mini-Mall Construction Project both city residents and Fort Detrick also includes plans for the construction On October 24, 2003, a ground- workers. The problem is especially of a golf course, parks and other breaking ceremony marked the bad during peak rush hour times as recreation areas on the post’s main beginning of the construction of a workers entering or leaving the fort Area “A” and Area “B.” Ø new mini-mall at the corners of Porter try to safely navigate around drivers Avenue and Ditto Street. The planned traveling down Seventh Street or 27,007 square foot mini-mall will turning onto Military Road. Next include a shoppette, military clothing spring, a $3 million renovation sales section, a Class Six, laundry/ project will reconfi gure the Seventh

The NCI-Frederick Poster 4 November 2003 Building 470 Update

By the time you are reading this, the dismantlement of Building 470 will nearly be completed. The contractors hope to fi nish by late December or early January. Safety inspectors have continued to monitor the site very carefully. In an update briefi ng in mid-October, Carol Shearer, Project Manager, noted that approximately 2,250 samples had been taken and tested for Bacillus anthracis. “We’ve run out of places to test,” she said. “Now we’re doing air samples.” Controlled Demolition, Inc., the fi rm chosen for this work, has been highly sensitive to the needs of NCI-Frederick employees, working inside the building as much a possible, and at night and on weekends when noise is less likely to disturb the important scientifi c work going on here. This last, third phase differed from the earlier phases in that since Buildings 431 and 469 are so close to 470, the separation had to be done by hand, brick by brick. Because of the close proximity of Buildings 431 and 469, plans as of mid-October were to stud out and waterproof the adjacent walls which were separated from 470 by only a few inches. As of this writing, more than 900,000 pounds of debris had been removed from the site, and 535,000 pounds of equipment and metal taken for smelting. Most of the rubble goes to the Frederick landfi ll, while metal is sent to Conservit in Hagerstown, which then sends the metal to North Carolina for smelting. Weekly postings are made to the Web site to keep you as up-to-date as possible. Go to http://web.ncifcrf.gov/ campus/470update/ for current information and pictures. The site is very specifi c and gives you detailed information about the current week’s planned activities, major equipment expected to be in place, and a description of the work to be performed. Ø

The NCI-Frederick Poster 5 November 2003 Scientifi c Publications, Graphics & Media News

Digital Video and linear digital video editing system, equipment in other parts of the world Multi-Media Capabilities signifi cantly advancing the unit’s that use different video playback Expanding ability to meet new requirements. standards (e.g., PAL, SECAM). Now, plans are on the drawing board Conversely, SPGM can also copy Media specialists in Scientifi c for space renovations that will provide foreign-standard tapes to conform to Publications, Graphics & Media modern audio and video recording the US standard. (SPGM; formerly “Publications”) studios and engineering space, Renovation to the SPGM facilities are expanding capabilities with the enabling the department to offer is scheduled to begin in late January acquisition of the most up-to-date services previously unavailable. 2004 and be completed on or about digital tools for both still and motion New services available now include April 1, 2004. If you have any sort image capture and processing. Over digital audio- and video-taping, sound of video or multi-media project in the past two years, in addition to and picture editing and fi nishing, and mind, there’s never been a better time transforming still photography from duplication and replication services. to consult with media professionals analog to all-digital, the department Products include fi nished audio and in SPGM (extension 1055) and begin has added two digital video cameras, video tapes, compact discs (CD), the planning. Ø new lighting equipment and a non- video compact discs (VCD), and digital versatile discs (DVD).

SPGM staff to convert video standards, that is, to copy a tape that normally plays only on standard equipment in the USA (the NTSC standard) to one that will play on

Awards

National Institutes of Health Wins Diversity Best Practices Award

On behalf of NIH and its 18,000 “I am very proud to represent you and NCI-Frederick continues in many employees, Dr. Elias Zerhouni, your accomplishments to promote ways to promote diversity in its NIH director, accepted the 2003 diversity at NIH.” He pointed out workforce; the Frederick Employee Diversity Best Practices Award on that NIH manager Larry Self and his Diversity Team works hard to create October 15. This annual award from team made “tremendous efforts to opportunities, sponsor activities, Diversity Best Practices recognizes promote diversity.” and develop outreach and education the achievements of organizations Dr. Zerhouni encouraged everyone initiatives that focus on diversity. that work to ensure a culturally and “to build on our successes so that See the article elsewhere in this issue ethnically diverse workforce. The the principles of inclusion are for profi les of the F-EDT members, only Federal government agency integrated completely into all facets or go to the F-EDT Web site, http: to be selected, NIH joined nine of our organization. As I said in my //diversity.ncifcrf.gov/fl ash_content/ other organizations in receiving the acceptance speech, the diversity default.asp. Ø honor, which was awarded through a among those of us who work to competitive process. improve people’s health must be In a recent global e-mail to NIH equal to the diversity of those we are employees, Dr. Zerhouni commented, working for.”

The NCI-Frederick Poster 6 November 2003 Awards

Dr. Nancy Jenkins Recognized for Efforts to Improve Animal Care Program

Recently, Dr. Craig Reynolds, and later worked as an Scientifi c Offi cer, NCI-Frederick, associate staff scientist at presented the Animal Care and Use The Jackson Laboratory and Committee Award to Dr. Nancy as associate professor of Jenkins. The award recognizes her microbiology and molecular achievements in improving the quality genetics at the University of the animal care program, including of Cincinnati College of employee training and involvement Medicine. Dr. Jenkins came of technicians and caretakers in the to NCI-Frederick in 1985 animal study process. as head of the Molecular Dr. Reynolds said that Dr. Genetics of Development Jenkins “has been at the forefront Section, ABL-Basic of controversial issues to ensure Research Program, then part progressive initiatives and to improve of the Mammalian Genetics the quality of the program” and Laboratory (MGL). to ensure that everyone involved In 1997, she became in a study was “educated on the editor-in-chief of Genomics animal study proposal, the Federal and in 1998 chair of the regulations, and ACUC policies/ then-FCRDC Animal procedures. Her initiatives have led Care and Use Committee. to several new and improved animal Dr. Reynolds noted, care and use training programs “This appointment is a for investigators, technicians, very highly regarded position in the its accreditation.” caretakers, and animal users at the laboratory animal fi eld and Dr. Jenkins In 1999, the MGL was incorporated NCI-Frederick.” has demonstrated how a dedicated into NCI’s Center for Cancer Research Dr. Jenkins earned a PhD in chairperson can maintain and improve and renamed the Mouse Cancer molecular and cellular biology at the quality of animal research Genetics Program (MCGP). Dr. University. Prior to joining conducted at an institution…she has Jenkins now heads the Molecular NCI-Frederick, she did postdoctoral provided exemplary leadership and Genetics of Development Section research at the Dana-Farber Cancer guidance to ensure that the NCI- within the MCGP. Ø Center and Harvard Medical School Frederick animal program has attained

Team of Mayo and Reeder Wins AALAS’ Highest Award

Earlier this fall, Dr. Joseph Mayo, Thomas E. Hamm, Jr., noted that “This Sciences Program in the 1970s, head of the Biologic Branch, NCI, and team greatly infl uenced the fi eld of “every single tumor within the NCI Clarence Reeder, SAIC-Frederick, Laboratory Animal Science throughout tumor bank was contaminated with at Inc. (now retired), received the Griffi n the world by promoting and least one adventitious murine virus.” Award, the American Association of sponsoring genetic standardization, The article went on to say that “The Laboratory Animal Sciences’ highest microfl ora standardization, and by level of sophistication of our fi eld award, at the AALAS annual meeting insisting that all NCI tumor cell lines owes a great debt to Dr. Mayo and in Seattle, Washington. A number be Map-tested and freed of any murine Clarence Reeder.” Ø of previous Griffi n Award winners virus contaminants.” and former presidents of AALAS An August CompMed article pointed supported the nomination. out that when Dr. Mayo became head In his letter of nomination, Dr. of the NCI’s Laboratory Animal

The NCI-Frederick Poster 7 November 2003 Platinum Highlights

Dr. Susanna Rybak co-authored this quarter’s Platinum Highlight with Rybak SM, Sanovich E, Hollingshead MG, Borgel SD, Newton DL, other members of the Developmental Melillo G, Kong DH, Kaur G, and Sausville EA Therapeutic Program (DTP) involved in anti-angiogenesis drug testing and development. She earned her PhD “Vasocrine” Formation of Tumor Cell-lined Vascular from the University of California San Spaces: Implications for Rational Design of Francisco, where she studied hormone Antiangiogenic Therapies mechanism of action with Dr. C.H. Li. Following postdoctoral training at Stanford University, Stanford, Cancer Research, 63(11):2812–2819, 2003 CA, and the Weizmann Institute of Science, Rehovot, Israel, Dr. Rybak Here we report that B16F10 murine melanoma cells mimic endothelial cell was appointed an Assistant Professor behavior and the angiogenic process in vitro and in vivo. Cord formation in of Pathology at Harvard Medical vitro by tumor cells is stimulated by hypoxia and vascular endothelial growth School and Research Associate in factor (VEGF) and inhibited by antibodies against VEGF and the VEGF KDR Pathology, Brigham and Women’s receptor (VEGF receptor 2). We defi ne regulation of tumor cell-derived vascular Hospital, Boston, MA. At Harvard space formation by these she worked on angiogenin and a vasoactive compounds as series of human serum ribonucleases, “vasocrine” stimulation. which she thought could potentially ICRF 159 (Razoxane; NSC be engineered into therapeutic agents 129943) prevents tumor via chemical and/or genetic means. cell but not endothelial cell She joined the National Cancer cord formation in vitro, and Institute in 1993 and in 1998 became the antiangiogenic drug a Senior Investigator in the DTP, TNP-470 (NSC 642492) where she continues to develop inhibits endothelial but not RNase-based therapeutics for clinical tumor cell cord formation use, along with more basic studies in vitro. Both drugs inhibit relating to tumor markers during the formation of blood-fi lled angiogenic process. vascular spaces in vivo. For more information, see: These results bear on the http://dtp.nci.nih.gov/aa-resources. Ø anticipated action of ICRF 159 in human clinical trials and novel strategies for targeting tumor blood supplies. Ø

The NCI-Frederick Poster 8 November 2003 Platinum Highlights

among Finnish men. Woodson K, Tan- dev AE, Lentschat A, Kuhns DB, Blanco The following 40 articles have been grea JA, Pollak M, Copeland TD, Taylor JCG, Salkowski C, Zhang SL, Arditi selected from a quarterly listing of PR, Virtamo J, and Albanes D. Cancer MH, Gallin JI, and Vogel SN. J Exp Med, publications in 13 of the most prestigious Res, 63(14):3991–3994, 2003. 198(4):521–531, 2003. science journals. Experimental Therapy Tumor regression and autoimmunity Biochemistry and Biophysics In vivo retroviral gene transfer by after reversal of a functionally toler- The cis decoy against the estrogen re- direct intrafemoral injection results in ant state of self-reactive CD8+ T cells. sponse element suppresses breast cancer correction of the SCID phenotype in Overwijk WW, Theoret MR, Finkelstein cells via target disrupting c-fos not Jak3 knock-out animals. McCauslin CS, SE, Surman DR, de Jong LA, Vyth-Dreese mitogen-activated protein kinase activ- Wine J, Cheng LZ, Klarmann KD, Can- FA, Dellemijn TA, Antony PA, Spiess PJ, ity. Wang LH, Yang XY, Zhang X, Mihalic dotti F, Clausen PA, Spence SE, and Keller Palmer DC, Heimann DM, Klebanoff CA, K, Xiao W, and Farrar WL. Cancer Res, JR. Blood, 102(3):843–848, 2003. Yu ZY, Hwang LN, Feigenbaum L, Kruis- 63(9):2046–2051, 2003. beek AM, Rosenberg SA, and Restifo NP. Bacillus anthracis lethal induces J Exp Med, 198(4):569–580, 2003. Cellular Biology and TNF-alpha-independent hypoxia-medi- Differentiation ated toxicity in mice. Moayeri M, Haines The four distal tyrosines are required Different cofactor activities in gamma- D, Young HA, and Leppla SH. J Clin for LAT-dependent signaling in Fc ep- secretase assembly: evidence for a nicas- Invest, 112(5):670–682, 2003. silon RI-mediated mast cell activation. trin-Aph-1 subcomplex. Hu Y and Fortini Saitoh S, Odom S, Gomez G, Sommers ME. J Cell Biol, 161(4):685–690, 2003. “Vasocrine” formation of tumor cell- CL, Young HA, Rivera J, and Samelson lined vascular spaces: Implications for LE. J Exp Med, 198(5):831–843, 2003. Involvement of Crm1 in hepatitis B rational design of antiangiogenic thera- virus X protein-induced aberrant cen- pies. Rybak SM, Sanovich E, Hollings- Engineering disulfi de bridges to dis- triole replication and abnormal mitotic head MG, Borgel SD, Newton DL, Melillo sect antimicrobial and chemotactic spindle. Forgues M, Difi lippantonio MJ, G, Kong DH, Kaur G, and Sausville EA. activities of human beta-defensin 3. Wu Linke SP, Ried T, Hagasima K, Fedem J, Cancer Res, 63(11):2812–2819, 2003. ZB, Hoover DM, Yang D, Boulegue C, Valerie K, Fukasawa K, and Wang XW. Santamaria F, Oppenheim JJ, Lubkowski Mol Cell Biol, 23(15):5282–5292, 2003. Phosphatidylinositol 3´-kinase is re- J, and Lu WY. Proc Natl Acad Sci USA, quired for growth of mast cells express- 100(15):8880–8885, 2003. BCL-2 and BCL-X-L restrict lineage ing the Kit catalytic domain mutant. choice during hematopoietic differentia- Shivakrupa R, Bernstein A, Watring N, Lipids and Lipoproteins tion. Haughn L, Hawley RG, Morrison and Linnekin D. Cancer Res, 63(15): Overexpression of the tumor autocrine DK, von Boehmer H, and Hockenbery 4412–4419, 2003. motility factor receptor Gp78, a ubiq- DM. J Biol Chem, 278(27):25158–25165, uitin protein ligase, results in increased 2003. Accelerated vaccination for virus ubiquitinylation and decreased secre- haemorrhagic fever in non-human pri- tion of apolipoprotein B100 in HepG2 Overexpression of kinase suppressor mates. Sullivan NJ, Geisbert TW, Geisbert cells. Liang JS, Kim T, Fang SY, Yama- of Ras upregulates the high-molecular- JB, Xu L, Yang ZY, Roederer M, Koup guchi J, Weissman AM, Fisher EA, and weight tropomyosin isoforms in ras- RA, Jahrling PB, and Nabel GJ. Nature, Ginsberg HN. J Biol Chem, 278(26): transformed NIH 3T3 fi broblasts. Jans- 424(6949):681–684, 2003. 23984–23988, 2003. sen RA, Kim PN, Mier JW, and Morrison DK. Mol Cell Biol, 23(5):1786–1797, Immunology Medicine 2003. Stat5 synergizes with T-cell receptor/ Lamin A truncation in Hutchinson- antigen stimulation in the development Gilford progeria. De Sandre-Giovannoli Anteroposterior patterning in hemi- of lymphoblastic lymphoma. Kelly JA, A, Bernard R, Cau P, Navarro C, Amiel chordates and the origins of the chor- Spolski R, Kovanen PE, Suzuki T, Bollen- J, Boccaccio I, Lyonnet S, Stewart CL, date nervous system. Lowe CJ, Wu M, bacher J, Pise-Masison CA, Radonovich Munnich A, Le Merrer M, and Levy N. Salic A, Evans L, Lander E, Stange-Thom- MF, Lee S, Jenkins NA, Copeland NG, Science, 300(5628):2055–2055, 2003. ann N, Gruber CE, Gerhart J, and Kirsch- Morse HC, and Leonard WJ: J Exp Med, ner M. Cell, 113(7):853–865, 2003. 198(1):79–89, 2003. Molecular Biology and Genetics The cis decoy against the estrogen re- Epidemiology and Prevention Distinct mutations in IRAK-4 confer sponse element suppresses breast cancer Serum insulin-like growth factor 1: hyporesponsiveness to lipopolysaccha- cells via target disrupting c-fos not Tumor marker or etiologic factor? A ride and interleukin-1 in a patient with mitogen-activated protein kinase activ- prospective study of prostate cancer recurrent bacterial . Medve- ity. Wang LH, Yang XY, Zhang X, Mihalic The NCI-Frederick Poster 9 November 2003 Platinum Highlights

K, Xiao W, and Farrar WL. Cancer Res, Hepatic vascular tumors, angiectasis in tide inhibitors with the beta-amyloid 63(9):2046–2051, 2003. multiple organs, and impaired sper- peptide. Chalifour RJ, McLaughlin RW, matogenesis in mice with conditional Lavoie L, Morissette C, Tremblay N, Identifying tumor origin using a gene inactivation of the VHL gene. Ma W, Boule M, Sarazin P, Stea D, Lacombe D, expression-based classifi cation map. Tessarollo L, Hong SB, Baba M, Southon Tremblay P, and Gervais F. J Biol Chem, Buckhaults P, Zhang Z, Chen YC, Wang E, Back TC, Spence S, Lobe CG, Sharma 278(37):34874–34881, 2003. TL, St Croix B, Saba S, Bardelli A, Morin N, Maher GW, Pack S, Vortmeyer AO, PJ, Polyak K, Hruban RH, Velculescu Guo C, Zbar B, and Schmidt LS. Cancer C-terminal octylation rescues an inac- VE, and Shih IM. Cancer Res, 63(14): Res, 63(17):5320–5328, 2003. tive T20 mutant - Implications for the 4144–4149, 2003. mechanism of HIV/simian immunodefi - Strong population substructure is cor- ciency virus-induced membrane fusion. Of mice and MEN1: Insulinomas in a related with morphology and ecology Peisajovich SG, Gallo SA, Blumenthal conditional mouse knockout. Crabtree in a migratory bat. Miller-Butterworth R, and Shai Y. J Biol Chem, 278(23): JS, Scacheri PC, Ward JM, McNally CM, Jacobs DS, and Harley EH. Nature, 21012–21017, 2003. SR, Swain GP, Montagna C, Hager JH, 424(6945):187–191, 2003. Hanahan D, Edlund H, Magnuson MA, Signal Transduction Garrett-Beal L, Burns AL, Ried T, Chan- Role of the reverse transcriptase, nu- Tyrosine phosphorylation disrupts drasekharappa SC, Marx SJ, Spiegel AM, cleocapsid protein, and template struc- elongin interaction and accelerates and Collins FS. Mol Cell Biol, 23(17): ture in the two-step transfer mechanism SOCS3 degradation. Haan S, Ferguson 6075–6085, 2003. in retroviral recombination. Roda RH, P, Sommer U, Hiremath M, McVicar DW, Balakrishnan M, Hanson MN, Wohr BM, Heinrich PC, Johnston JA, and Cacalano Differing roles of the N- and C-terminal Le Grice SFJ, Roques BP, Gorelick RJ, NA. J Biol Chem, 278(34):31972–31979, zinc fi ngers in human immunodefi cien- and Bambara RA. J Biol Chem, 278(34): 2003. cy virus nucleocapsid protein-enhanced 31536–31546, 2003. nucleic acid annealing. Heath MJ, Dere- Protein 14-3-3 sigma interacts with and bail SS, Gorelick RJ, and DeStefano JJ. J Pdcd4 suppresses tumor phenotype favors cytoplasmic subcellular local- Biol Chem, 278(33):30755–30763, 2003. in JB6 cells by inhibiting AP- 1 trans- ization of the glucocorticoid receptor, activation. Yang HS, Knies JL, Stark acting as a negative regulator of the Inactivation of RAS association domain C, and Colburn NH. Oncogene, 22(24): glucocorticoid signaling pathway. Kino family 1A gene in cervical carcinomas 3712–3720, 2003. T, Souvatzoglou E, De Martino MU, and the role of human papillomavirus Tsopanomihalu M, Wan YH, and Chrousos . Kuzmin I, Liu L, Dammann PSF acts through the human immuno- GP. J Biol Chem, 278(28):25651–25656, R, Geil L, Stanbridge EJ, Wilczynski SP, defi ciency virus type 1 mRNA instability 2003. Lerman MI, and Pfeifer GP. Cancer Res, elements to regulate virus expression. 63(8):1888–1893, 2003. Zolotukhin AS, Michalowski D, Bear Transplantation J, Smulevitch SV, Traish AM, Peng R, IL-10 and TGF-beta induce alloreac- Nonpolar thymine isosteres in the Ty3 Patton J, Shatsky IN, and Felber BK. Mol tive CD4(+)CD25(-) T cells to acquire polypurine tract DNA template modu- Cell Biol, 23(18):6618–6630, 2003. regulatory cell function. Chen ZM, late processing and provide a model for O’Shaughnessy MJ, Gramaglia I, Panos- its recognition by Ty3 reverse transcrip- Bacterial polymerase and yeast poly- kaltsis-Mortari A, Murphy WJ, Narula S, tase. Lener D, Kvaratskhelia M, and Le merase II use similar mechanisms for Roncarolo MG, and Blazar BR. Blood, Grice SFJ. J Biol Chem. 278(29):26526– transcription through nucleosomes. 101(12):5076–5083, 2003. 26532, 2003. Walter W, Kireeva ML, Studitsky VM, and Kashlev M. J Biol Chem, 278(38): Tumor Biology Hermansky-Pudlak syndrome type 7 36148–36156, 2003. Lsh-defi cient murine embryonal fi bro- (HPS-7) results from mutant dysbindin, blasts show reduced proliferation with a member of the biogenesis of lysosome- Physics signs of abnormal mitosis. Fan T, Yan related organelles complex 1 (BLOC- Phonon dispersions of fcc delta-pluto- QS, Huang JQ, Austin S, Cho E, Ferris 1). Li W, Zhang Q, Oiso N, Novak EK, nium-gallium by inelastic X-ray scatter- D, and Muegge K. Cancer Res, 63(15): Gautam R, O’Brien EP, Tinsley CL, Blake ing. Wong J, Krisch M, Farber DL, Occelli 4677–4683, 2003. DJ, Spritz RA, Copeland NG, Jenkins F, Schwartz AJ, Chiang TC, Wall M, Boro NA, Amato D, Roe BA, Starcevic M, C, and Xu RQ. Science, 301(5636): Virology Dell’Angelica EC, Elliott RW, Mishra V, 1078–1080, 2003. Weapons of mutational destruction. Ke- Kingsmore SF, Paylor RE, and Swank RT. walRamani VN and Coffi n JM. Science, Nat Gen, 35(1):84–89, 2003. Protein Structure and Folding 301(5635):923–925, 2003. Ø Stereoselective interactions of pep- The NCI-Frederick Poster 10 November 2003 Poster-Script

Halloween Costume Contest

The NCI-Frederick Poster 11 November 2003 Did You Know...?

A Look Back

A fun way to celebrate an 1971 anniversary is to look back over the years and remember the “good All Ft. Detrick buildings were ol’ days.” So, to honor the more declared safe for occupancy. The than 30 years of research at NCI, National Institutes of Health took we’ve decided to take a look back at ownership of the surrounding lifestyles and some of the memorable buildings, which were then events of 30 years ago. Some of them retrofi tted for cancer and infectious may even bring a smile. disease research.

October 19: President Nixon announced the conversion of Fort Detrick biological warfare laboratories to cancer research initiatives, “beating its swords into plowshares.”

1972 June 26: Litton Bionetics’ October 12: Students and faculty of Frederick Operations Division the Advanced Biology class at North opened the Frederick Cancer Hagerstown High School visited Research Center (FCRC), with the FCRC. a staff of 21 employees. Phones For example, remember when had to be installed, a huge inventory October 17: The fi rst issue of the money could actually buy something? of equipment had to be checked out, FCRC Bulletin was published. A A 2-bedroom apartment with air numerous supplies had to be ordered contest was announced to name conditioning (considered a luxury) – and there wasn’t a coffee pot in the the bulletin. The prize was a $25 rented for $200 a month; a 1-bedroom place. Three months later, the number savings bond. Ø apartment downtown went for $165 a of employees had increased almost month. House prices in the area ranged tenfold, to 193. from $21,000 (for a townhouse) to $140,000 for a 3-bedroom, stone September 19: President colonial on 56 acres with an in-ground Nixon expressed the pool. A new car cost between $2,000 wish to “open the and $3,500. Of course, an entry- Center’s doors to visiting level scientist earned approximately scientists from every $15,180 annually (before taxes). part of the world… offering the hospitality Here are some other interesting and collegiality of the tidbits from 30 years ago: NCI to any researcher seeking scientifi c truth about cancer.” 1970-1971 Building 470 was decommissioned. October 2: The fi rst 13,000 samples were taken from the “blessed event” under the building during decommissioning, to new FCRC program occurred, with the test for evidence of anthrax (Bacillus birth of two Strain 13 guinea pigs. anthracis). None was found. Archive photos, U.S. Army Garrison, Ft. Detrick The NCI-Frederick Poster 12 November 2003 Did You Know...?

NCI-Frederick among Top Ten Best Places to Work Worldwide

Did you know that the NCI-Frederick came in seventh on the “2003 Best Places to Work in Scientifi c Institutions” poll conducted by The Scientist (October 20, 2003)? The Scientist used the results from 2,210 full time researchers from North America and Western Europe who rated the working conditions and overall environment at academic institutions and private research centers to compile the top ten list.

The Top Ten Best Places to Work in Scientifi c Institutions 1. Fox Chase Cancer Center, Philadelphia, PA 2. Purdue University, West Lafayette, IN 3. Yale University, New Haven, CT 4. University of California, San Francisco, CA 5. University of Minnesota, St. Paul, MN 6. Cornell University, Ithaca, NY 7. National Cancer Institute, Frederick, MD 8. Michigan State University, Lansing, MI 9. University of Nebraska, Lincoln, NE 10. University of Texas, Southwestern Medical Center, Dallas, TX Ø

Twenty Years of Citation Superstars

ScienceWatch (http:// www.sciencewatch.com/sept- oct2003/sw_sept-oct2003_ page2.htm), a section of Past displays in the Diversity Essential Science Indicators, Cabinet in Building 549: on recently noted that two left, the worldwide variety in NCI-Frederick scientists are medicinal plants refl ects the among the top 50 researchers diversity in people; above, cited most often between celebrating the women of 1983 and 2002. Dr. Neal NCI-Frederick. Ø Copeland has had 38,032 citations for 696 papers, while Dr. Nancy Jenkins has had 37,146 citations for 691 papers. Ø

New User Suggestions Web Sites Two new User Suggestions Web sites have been activated to enable the NCI-Frederick community to send in comments and suggestions to service providers. Suggestions and comments for Scientifi c Publications, Graphics & Media (SPGM), formerly known as “Publications,” can be sent to http://web.ncifcrf.gov/campus/committees/publications.asp. NCI- Frederick personnel can now submit suggestions and comments concerning the NCI-Frederick Childcare Center (PALS) online at http://web.ncifcrf.gov/campus/committees/childcare.asp. Ø

The NCI-Frederick Poster 13 November 2003 Technology Transfer Branch (TTB)

Technology Transfer Branch Helps You Meet the NCI Challenge

NCI has challenged scientists to NIH and outside organizations, and program’s research focus and are eliminate, by 2015, the suffering and ensuring that the necessary agreement better able to assist with specifi c death due to cancer. To help NCI and satisfi es research objectives, NIH technology transfer needs. SAIC-Frederick, Inc., scientists meet IP policies, and Federal law. TTB this challenge, the NCI Technology staff handle day-to-day negotiations, New Inventions Transfer Branch (TTB) manages as well as all other aspects of the TTB-Frederick, the fi rst point of intellectual property for the NCI, agreement process, so that NCI contact and liaison for NCI-Frederick obtains research materials, establishes scientists can spend less time on scientists when they make exciting discoveries, assists them in reporting all potential inventions. Staff help gather all the necessary information for reviewing the discovery to determine if patent protection is warranted and provide a summary to the Division Director for his decision to authorize funds for patent prosecution as appropriate. As an added incentive and following NIH policy, NCI shares with its inventors a signifi cant portion of the royalties from the successful licensing of the invention(s). The invention reporting process begins when you fi ll out the Employee Invention Report (http:// Pictured, left to right, are Technology Transfer Branch staff: Captain ttb.nci.nih.gov/eirst.doc) and submit it Steven Wickizer, Pharm.D., Technology Transfer Specialist; Dr. Charmaine for review to your TTB representative. Richman, Technology Transfer Specialist; Dr. Jeffrey Thomas, Senior Among other services offered, TTB Advisor, Contract IP; Dr. Thomas Stackhouse, Associate Chief; Dr. Bjarne also negotiates with outside parties, Gabrielsen, Senior Advisor, Drug Discovery and Development; Vio Conley, transactional agreements designed to Technology Development Administrative Specialist; and Donna Bialozor, meet your unique needs. Technology Transfer Specialist. Obtaining or Providing public/private partnerships, and paperwork and more time on research. Research Materials and oversees and advises NCI scientists In addition, the TTB-Frederick Information and administrative managers on satellite offi ce’s proximity to NCI- ● Material Transfer Agreement/ matters related to IP management/ Frederick, in the Fairview Center, Simple Letter Agreement (MTA/ strategy for these exciting Suite 500, 1003 West Seventh Street, SLA)—gives your laboratory access to NCI initiatives. enables staff to work effectively with critical research materials from outside The NCI-TTB recognizes that NCI-Frederick staff on technology organizations or permits NCI materials interactions with researchers outside transfer issues. TTB staff members, to be provided to other researchers. NIH help NCI scientists answer professionals with expertise in ● Confi dential Disclosure Agreement the NCI challenge. Whether these diverse areas such as drug discovery, (CDA)—provides free exchange of interactions involve collaborating on molecular biology, chemistry, confi dential research information a research project or simply obtaining pharmacology, biochemistry, contract with an outside party while ensuring research materials unavailable at IP, and transactional agreements, are control over public disclosures prior to NIH, TTB plays an important role, individually assigned to programs publication or application for a patent. supporting the NCI scientists’ efforts or laboratories so that they become ● Clinical Trials Agreement (CTA)— by negotiating agreements between the familiar with the laboratory or facilitates the transfer of clinical

The NCI-Frederick Poster 14 November 2003 Technology Transfer Branch (TTB) research materials from outside (LOC)—specialized, collaborative provide you with needed and timely parties for use in NCI-sponsored agreements with national governments advice on the issues associated with clinical trials. and/or their institutions focused the development and management ● Materials Cooperative Research on biodiversity and traditional of intellectual property, such as and Development Agreement medicines; used to obtain synthetic inventorship, patent protection (why, (MCRADA)—gives your laboratory compounds and natural product how, when, where…) and royalty access to company-proprietary materials derived from plants, marine income to inventors. materials not commercially available. macro-organisms, and microbes for ● Education—keeping you posted on the NCI Developmental Therapeutics the latest developments in technology Establishing Formal Program. These materials provide development and transfer and training Collaborations valuable structural leads for screening of new employees. ● Cooperative Research and and optimization in the drug Development Agreement (CRADA)— discovery process of antiviral and Keep an eye out for future Poster fosters collaborative research with anticancer agents. articles featuring more details of outside organizations; can help your TTB services, plus highlights from laboratory exchange and obtain Additional TTB Services your colleagues who have used TTB access to unique expertise, personnel, ● Marketing—promotes NCI services to help them meet their part in services, facilities and equipment. technologies to outside organizations the NCI Challenge. CRADAs assist in the public/private to foster research collaborations It’s easy to obtain TTB-Frederick’s partnering needed to accelerate the at various scientifi c, business, and services. To determine which TTB discovery, development and delivery technology transfer meetings and staff members have been assigned to of important new diagnostics, conferences. your laboratory, please contact TTB- prognostics and therapeutics. ● Advice on intellectual property Frederick at (301) 846-5465 or http: ● Memorandum of Understanding issues—TTB coordinates with other //ttb.nci.nih.gov. Ø (MOU) and Letters of Collection offi ces within NCI and NIH to

Community Outreach

In our last issue, one of our student media. Students must attend a school junior in high school (when applying), interns described how she had learned within the Frederick or Washington have an overall grade point average of to see beyond the “scientist” images County Public School Systems or St. 3.0 or greater, and be a U.S. citizen or she had of her colleagues. But what John’s Literary Institute at Prospect permanent resident. exactly do these young interns do? Hall. Currently (2003-2004), the SIP How do scientifi c and administrative has 37 sponsors mentoring 43 students. To fi nd out more about this program, internships differ? The sponsors represent a diverse cross- please visit the Web site at http: section of science at NCI-Frederick. //web.ncifcrf.gov/careers/student_ Student Intern Program Scientifi c interns work full-time (40 programs/internships/SIP.asp. The Werner H. Kirsten Student hours per week) for nine consecutive We are always looking for new Intern Program (SIP) at the National weeks during the summer (training mentors, so please consider mentoring Cancer Institute (NCI) at Frederick period) and receive a stipend of a student next year. is designed to expose high school approximately $2,900. Administrative seniors to research and administrative interns, on the other hand, are not Elementary Outreach Program management in a health care required to work during the summer The program is up and running for environment. The scientifi c interns and, therefore, do not receive a the 2003-2004 school year. If you experience the basic methods of stipend. All interns work three hours would like to learn more about the cancer research through hands-on per day during the school year as program or volunteer, please visit http: laboratory training. Administrative student volunteers (no stipend) and //web.ncifcrf.gov/campus/outreach/. management interns are assigned receive credit toward their diplomas. An expanded Web site is under projects in budget, personnel, To be eligible for the SIP, a student construction. Ø information technology, graphics and must be at least 16 years of age and a

The NCI-Frederick Poster 15 November 2003 Offi ce of Diversity and Employee Programs

The Frederick Employee Management programs; and in the says, “I especially appreciate the Diversity Team mid-1990s she began managing opportunity I had to be part of both [Editor’s note: In the previous issue, Dr. Scott various projects from within FAS. diversity groups’ groundbreaking Keimig described the goals and discussed the Carmen states that the evolution of efforts and to celebrate, share, and special events that the Frederick Employee the NCI-Frederick over the years has promote our rich diversity throughout Diversity Team has sponsored. In this issue, required great teamwork on the part the Fort Detrick community.” he introduces us to several F-EDT charter of a diverse and constantly changing members.] population. Shannon Bell works in the Offi ce of Carmen’s hobbies include raising Diversity and Employee Programs Since 2001, the Frederick two miniature horses (and, at one (ODEP) at the National Cancer Employee Diversity Team (F-EDT) time, seven minis and four llamas!), Institute, where she runs the ODEP has been celebrating diversity. The a pot-bellied pig, two goats, three Frederick satellite offi ce, bringing their team’s mission includes creating cats, and two guinea pigs on South numerous programs and services to the opportunities, sponsoring activities, Mountain in Myersville. Carmen states Frederick community; she oversees and developing outreach and education this has been both an educational the NCI’s administrative intern initiatives that and entertaining experience. She also programs and university outreach and enjoys slalom water skiing, music, and recruitment programs. Additionally, ● Foster respect for all employees on gardening. Carmen is a fi rst-generation she is the NCI Diversity Catalyst and the Frederick campus; American and was born in Sonthofen, Chairperson of the Salutaris employee Germany. She received her American group that represents and advocates ● Celebrate the rich diversity that citizenship at 16, something she states for the gay, lesbian, bisexual and age, race, gender, ability, personality, that neither she, nor her war-displaced transgendered (GLBT) employees culture, national origin, religious family, has ever taken for granted. and works to foster a workplace that beliefs, sexual orientation, veteran Carmen believes it is a true privilege is accepting and supportive of GLBT status, marital status, job classifi cation to be an American. employees throughout NIH. Shannon and other personal and organizational also volunteers on the Montgomery characteristics bring to the workplace; Ethel Armstrong is a Manager of County Hate and Violence Partnership and Interlibrary Loans (WISCO). She Board, whose mission is to help started working at the National Cancer compensate individuals who have ● Create and maintain a work Institute over 20 years ago. She is the been victims of hate crimes. Originally environment that values differences Acting Chair 2003 and Chair Elect from Wyoming, she moved to the and similarities among all employees 2004 of the Maryland Association Frederick area in 1999 with her partner and promotes productivity, work of Interlibrary Loan Librarians and two children. Her hobbies include quality, equity, and respectful and a member of the Membership martial arts, reading and playing with communication. Committee of the Maryland Library her new puppy, but what she enjoys Association. Her hobbies include most in life is being blessed with two Charter F-EDT members include collecting dolls, miniature shoes, phenomenal children. Carmen Anderson, Ethel Armstrong, and handbags, but her greatest love Liz Battle, Shannon Bell, Peter is traveling. Ethel has visited every Peter Boving was Manager of Boving, Teri Cecil, Deepti Dave, Scott continent except Africa. Protective Services from 1987 Keimig, Paul Miller, Cheryl Parrott, through 2002 and is now Senior and Howard Young. Liz Battle, an Employment Specialist/ Fire Prevention Specialist. His other Recruiter for SAIC-Frederick, Inc., interests include international cuisine, Carmen Anderson, Project was a member of the EEET (Employee languages, radio, hiking and Nordic Coordinator at the Financial and Environment Team), which dissolved skiing. Administrative Systems (FAS) at in June 2000. She continues to be a SAIC-Frederick Inc., began working member of the newly formulated F- Teri Cecil, Administrative Offi cer for at NCI-Frederick in the mid-1970s EDT (Frederick Employee Diversity several laboratories at NCI-Frederick, as a Research Assistant. In the early Team). Liz has had the distinct has worked for NIH since 1970. 1980s, she became responsible for honor of being employed for three Her numerous responsibilities in the Repository, Glassware, and Space contractors at NCI-Frederick. She the Administrative Resource Center

The NCI-Frederick Poster 16 November 2003 Offi ce of Diversity and Employee Programs include managing the resources their heritage and they share the same of Public Affairs. A former instructor of three laboratories (LECB, LEI, desires and aspirations. at Frederick Community College, she and LIB) where she handles issues holds degrees in French and German related to personnel, travel, budget, Scott Keimig was born and raised in literature. When she’s not at NCI, she procurement, space, contracts and the upper Midwest. He is the oldest enjoys gardening with her family and IAG; negotiating grants with the of seven children and is of Norwegian their three geriatric cats. Army; mentoring administrative lab (Telemark) ancestry. Scott did his managers; and overseeing special graduate work in public health at the Howard A. Young received a B.S. projects. Even so, she fi nds time to be University of Iowa, supported by a in microbiology from the University involved with the Frederick Employee CDC traineeship, and received a post- of Massachusetts and his PhD from Diversity Team. Teri and her husband doctoral appointment at Brookhaven the Department of Microbiology, have two children, Zackery and Katey. National Laboratory, NY. He relocated University of Washington. He joined A native Fredericktonian, she enjoys to NCI-Frederick in 1984 as a research NCI-Frederick in 1983 as a Cancer outside activities such as going to the scientist. He recently received Expert in the Laboratory of Molecular beach, reading, and walking her dogs, his MBA from the University of Immunoregulation and in 1989 Montana and Taylor. A new addition Maryland. Scott has been married for became Head, Cellular and Molecular to her family, her “grandpuppy,” Jeter, 29 years to Dr. Deborah Gellerman, Immunology Section, Laboratory keeps her hopping, too. One of her Division Chief of Epidemiology, of Experimental Immunology. His favorite pastimes is throwing parties; Armed Forces Medical Command. He research focuses on gene regulation in Teri loves to plan social events such is a third-generation motorcyclist and natural killer cells. He is the president- as Super Bowl parties, holiday parties teaches motorcycle safety at Frederick elect of the International Society of and other special occasions for her Community College. Scott also Interferon and Cytokine Research family, friends and neighbors. enjoys travel, tent camping, pond and and is a member of the American woodlands gardening, cooking, and Association of Immunologists, Deepti Dave, who has a degree in trying to domesticate Manx cats. the American Association for the microbiology and computer science, Advancement of Science, the has been working as a Programmer Paul Miller is a relatively new American Society for Biochemistry Analyst with Data Management member to the Team, although he has and Molecular Biology, the American Services for 15 years. She immigrated been at NCI-Frederick since 1981. Society for Microbiology and the from India 25 years ago and settled Paul holds both a Master’s of Science DNA Methylation Society. He has in Frederick 20 years ago with her and an MBA degree and works in the received an NIH Merit Award for husband and two beautiful daughters. Offi ce of the Director, NCI-Frederick, his efforts in support of the Werner Deepti is active in various community as a Program Analyst. Paul operates Kirsten Student Intern Program, services; she founded the Indian the monthly Diversity Café Movie the NCI Quality of Worklife Award Association of Frederick County series for the F-EDT. In addition and the NIH Director’s Award for when she realized the need for an to his work at the NCI, Paul also Mentoring (2000). He has chaired organization to help newly arrived runs a cancer support group and is a the NIH Cytokine Interest Group, Indians and their families adjust volunteer speaker for the American the annual NCI-Frederick–Ft. to their new environment. This Cancer Society. In his free time, he Detrick Spring Research Festival, association continues to thrive and likes to read, camp, hike and bike ride. and the Immunology Division of the have a large membership. Deepti American Society for Microbiology, served as Cultural Arts president with Cheryl Parrott, Director of Public and currently co-chairs the NIH the PTA at her daughters’ school. Affairs at NCI-Frederick, has been Immunology Interest Group. Ø She has also worked with the Human a biomedical writer for the National Relations Commission of Frederick Institutes of Health and the U.S. County, organizing the Ethnic Festival Army Medical Research Institute of Frederick. She loves meeting of Infectious Diseases. She came to people from different cultures. Deepti NIH in 1997 from Dugway Proving appreciates the fact that people are the Ground in Utah, where she was chief same everywhere. They are proud of

The NCI-Frederick Poster 17 November 2003 Environment, Health, and Safety Program

Now What Am I Signing? Center for Health Information: A If you have been to Occupational Failure to provide certain health Collaborative Effort Health Services in the past few information may prohibit clinical months, you have probably noticed staff from providing services relevant The NCI-Frederick’s Center for a change in some of the paperwork. to that information, such as denial Health Information (CHI) is a Some of the changes are based on a of medication prescriptions and collaborative project between the new law about privacy practices, and clearances for particular protective Scientifi c Library, Occupational other changes are to clarify existing equipment, travel assignments, or Health Services (OHS) and the forms and consents. Below is a fi tness for duty. Providing incorrect Employee Assistance Program paperwork primer. information may be grounds for (EAP). Conveniently housed in the termination.” Scientifi c Library, Building 549, the The Notice of Privacy Practices CHI resources include books, videos, This document is given to employees A complete copy of the Privacy brochures, and a computer for you to as they come through for new hire Practices notice is available in OHS research medical information. New or periodic evaluations. We ask during business hours. resources are added regularly. that you sign a salmon-colored You can utilize the Center to inquire acknowledgment to demonstrate that The Medical History into specifi c medical conditions, you have received a copy. The notice Questionnaires medications or treatments. You lets you know how we handle your If you are a government employee, can do your own research, or you medical information and allows you the new hire medical history form we may be guided by OHS staff, your to make specifi c requests for practices use is the same as those provided in personal healthcare provider, or the such as notifi cation of appointments or Bethesda or any other federal facility Library staff. results of medical tests or procedures. since 1996. We do not alter the form. Like OHS and the EAP, the Scientifi c If you are a contractor employee, Library protects your privacy as one Below are the fi rst three paragraphs: we provide an industrywide, standard of its clients. In accordance with the personal medical, family medical, Library’s policy on confi dentiality, “THIS NOTICE DESCRIBES and occupational history form. The staff will not reveal transactions HOW MEDICAL INFORMATION form was recently evaluated for indicating the use of specifi c ABOUT YOU MAY BE USED appropriateness and approved by an resources by individual users. Records AND DISCLOSED AND HOW outside, independent consultant. Minor pertaining to the use of the Library YOU CAN GET ACCESS TO THIS changes, such as a reference to the and its resources and subjects of INFORMATION. PLEASE REVIEW Privacy Practices notice, have been inquiry are confi dential, and shall IT CAREFULLY. made to the form at his suggestion. We not be disclosed either to other users, ask you to complete a long version of to unauthorized staff, or to other “Occupational Health Services is the form at your fi rst appointment, and inquirers. required, by law, to maintain the a shorter, interval form at subsequent Information you obtain from the privacy and confi dentiality of your visits. The third paragraph of the Center is not intended to replace the protected health information and Privacy Practices quoted above applies advice of your health care professional to provide you with notice of our to this information. Ø but to assist you in making informed legal duties and privacy practices decisions regarding your health care with respect to your protected health choices. We encourage you to consult information. OHS, personal care providers, or the EAP with your questions or concerns “Providing health information on the that are generated from use of the CHI medical history form, interval history or other resources. Ø form, any other requested form or in person is voluntary. Information is used for purposes such as determining potential health hazards, differential diagnosis, and suitability for duty.

The NCI-Frederick Poster 18 November 2003 Charles River Laboratories (CRL)

Congratulations to Linda success of APA, especially in recent Blumenauer, who will be years as she took on the additional transferring from her current job responsibilities of the surgical program as Technical Operations Manager and the Mouse Models of Human of the Animal Production Cancers Consortium Repository. We at Area (APA), Charles River Charles River Laboratory wish Linda Laboratories, to NCI Project the very best in her new endeavors, Offi cer for the NCI Animal although we will miss her greatly. We Program, a position long held by have no doubt that she will perform the now-retired Clarence Reeder. in an exceptional manner as Project Linda has been a key player at Offi cer, just as she did for so many the APA for 25 years and through years at APA. Ø three different contractors. Her exceptional technical skills and knowledge of the operation have been invaluable for the

Data Management Services (DMS)

Computer and Statistical Services

DMS has managed the Computer and Statistical Services (C&SS) contract for the last 16 years, and we remain committed to providing a wide array of information science expertise to further NCI-Frederick’s mission.

Although perhaps most widely known for our Microcomputer Support and Web Development services, many C&SS employees work “behind the scenes” to keep the information systems and infrastructure running smoothly and effi ciently; their anonymity is a testament to their effectiveness. This September, however, Wayne Duncan and Pete Bostian received the Outstanding user or users who provide the most is used at the NCI-Frederick for Technical User award at the Cyborg outstanding technical solution or contractor Payroll and Human User’s Association conference. This enhancement to Cyborg; Cyborg Resources. Ø award is presented annually to the continued on page 20

The NCI-Frederick Poster 19 November 2003 Data Management Services (DMS) continued from page 19 Statistical Consultation NCI-Frederick. C&SS staff would important data from , please be happy to meet with you to discuss visit http://css.ncifcrf.gov/helpdesk/ The Statistical Consultation your specifi c technology needs. virus.asp, or contact the Helpdesk for group provides a wide array of further information or assistance. mathematical and statistical consulting Computer Software services to the NCI-Frederick New Site-Licensed scientifi c community. The Director Training and consulting statisticians work The fall semester of computer Software Available in collaboration with principal software training classes is already from the Helpdesk investigators through all facets of the underway. Several new courses SAS for Windows 9.0 joins the scientifi c process: from development have been added to complement the growing list of site-licensed software and formulation of research and extensive list of classes offered to freely available from the Computer statistical hypotheses through design NCI-Frederick employees. Please see Services Helpdesk. Please contact the of experiments and statistical analyses, the Computer Software Training Web Helpdesk to borrow the software or preparation of technical reports and site at http://css.ncifcrf.gov/training see http://css.ncifcrf.gov/helpdesk/ modern graphics, to preparation for more information or to register for software.asp to review the complete of formal scientifi c documents classes. list of available titles. Ø and publications in peer-reviewed journals. The contributions of individual members of our statistical Computer Services staff are frequently recognized by an Helpdesk acknowledgment or by inclusion of the The Computer Services Helpdesk Contacting C&SS statistician as a co-author. provides the NCI-Frederick community with a single point of contact for computer assistance, Computer Services Custom Software information, service, and support. Helpdesk Development The Helpdesk is staffed from 8:00 a.m. to 5:00 p.m., Monday to Friday, Web: Our team of analysts and excluding NCI-Frederick holidays. http://css.ncifcrf.gov/helpdesk developers employ the most modern Requests for service can also be E-Mail: methodologies and tools to create placed via the C&SS Web site (http: [email protected] custom software solutions to meet //css.ncifcrf.gov/helpdesk) 24 hours Phone: 301-846-5115 the unique needs and requirements per day, seven days a week. of the NCI-Frederick. Our staff can Hours of Operation: assist you with both administrative and scientifi c programming needs as Protect Yourself from 8:00 a.m.–5:00 p.m., well as Web design and development Computer Viruses Monday through Friday services. Visit the C&SS Web site at This summer, the entire country http://css.ncifcrf.gov or call x 1060 experienced a rash of virus attacks NCI-Frederick Webmaster for more information about custom which crippled many organizations. development services available The Maryland Motor Vehicle Phone: 301-846-6700 from C&SS. Administration even closed its doors E-Mail: after a virus struck its computer [email protected] Technology Advocacy and systems! While many computers at NCI-Frederick are automatically Other Inquiries Consultation protected from most viruses by C&SS’ As the NCI-Frederick’s information automated anti-virus system, there Phone: 301-846-1060 technology experts, C&SS continually are still a large number of systems explores and evaluates new technolo- which have either outdated anti-virus gies that could benefi t the user com- software or no anti-virus software munity and further the mission of at all. To protect your system and

The NCI-Frederick Poster 20 November 2003 SAIC-Frederick, Inc.

US Flag from Operation Registry fees every two years (when leadership qualities…to SAIC.” Dr. Enduring Freedom submitting your CEUs), according to Beyster will continue as chairman of Presented to BDP the AALAS fl yer. the Board of Directors until July 2004. In a recent global e-mail to SAIC Recently, Staff Sergeant Gillis The following people, from both NCI- employees, Dr. Beyster said, M. Bolden, Jr., U. S. Army, fi ancé Frederick and NCI-Bethesda, have “Together, we have built a premier of Ms. Lydia Lopez, Secretary, recently been certifi ed: company that is legendary in many Biopharmaceutical Development circles. In the 34-plus years that Program (BDP), SAIC-Frederick, Inc., Mary Albaugh LAT I’ve watched this company grow, presented BDP with a Ranee Baker LAT I’ve had the privilege to work side- fl ag that had fl own in front of the U.S. Katharine Bergstrom ALAT by-side with some of the most Embassy in Afghanistan. Sergeant Carrie Bonomi ALAT talented, high-caliber individuals Bolden was stationed at the U.S. Suzanne Borgel ALAT that are the envy of our competitors. Embassy, Kabul, Afghanistan, from John Buckley LATG SAIC’s customers recognize our October 2002 through April 2003. Lisa Craig-Davis LATG willingness to take on the nation’s A signed certifi cate by Robert Finn, Kelly Dougherty ALAT most complicated technical challenges U.S. Ambassador to Afghanistan, Angie Hackley ALAT and our dedication and commitment accompanies the fl ag. The fl ag will Victoria Keck ALAT in getting the job done. I believe that “tour” NCI-Frederick September Mary May ALAT my conviction to help our government through November and will then be Matthew McCollum ALAT on issues of national importance is displayed in Building 458. Ø Catherine Morgan ALAT refl ected in all of you, and for that I Tamara Morgan ALAT am truly proud. Not only have we built Stephanie Newborg ALAT a company that is fi lled with talent, but 20 Earn AALAS Raul Santacruz ALAT SAIC also is known for its thorough Karen Shankle ALAT professionalism, for its strong sense Certifi cation Charlene Shaw LATG of values and ethics, and for its Like many groups on the NCI- Carol Smith ALAT entrepreneurial spirit.” Frederick campus, Laboratory Lori Warg LAT Ø He continued, “Going forward, Animal Sciences Program (LASP) we must endeavor to maintain employees maintain effi ciency and our remarkable legacy. Ken has constantly refi ne their expertise demonstrated the leadership qualities, through national certifi cation by the SAIC Corporate Elects the desire, and the commitment to American Association for Laboratory New CEO help us do that. He also has shown Animal Science (AALAS), the highest SAIC Corporate’s Board of Directors an appreciation and understanding recognition technicians can achieve. has unanimously elected Kenneth C. of why SAIC’s employee-ownership Certifi cation is awarded at three Dahlberg to succeed J. Robert Beyster culture has been the cornerstone of our levels: Assistant Laboratory Animal as the company’s next CEO, effective success since the company’s founding Technician (ALAT), Laboratory November 4, 2003. in 1969.” Ø Animal Technician (LAT), and Last April Dr. Beyster presented Laboratory Animal Technologist to SAIC’s Board of Directors a (LATG), with the latter being the succession plan for the smooth and highest level. To be certifi ed at orderly transition of the CEO position. each level, you must meet certain The Board approved the plan and prerequisites in education and established a Search Committee. experience, and pass a certifi cation Among numerous well-qualifi ed examination, after which you are listed candidates, Kenneth Dahlberg, in a Technician Certifi cation Registry General Dynamics’ executive for two years. To continue, you must vice president for its Information take continuing education units Systems and Technology Group, was (CEUs) on a 1-year schedule, maintain chosen. Dr. Beyster commented that your AALAS membership, and pay Mr. Dahlberg brings “tremendous

The NCI-Frederick Poster 21 November 2003 Wilson Information Services Corporation (WISCO)

Entertainment for Snow Days Curing Cancer: The Story of the Men and Women Unlocking the The prognosis has been made, and it isn’t good: this winter is expected to Secrets of Our Deadliest Illness. be snowy, so at times you may be cooped up with only television to entertain Michael Waldholz. QZ 201.W163 you. What better opportunity will you fi nd to catch up on those Science in the 1997. Veteran Wall Street Journal Cinema programs you missed, or read a book? Perhaps the Scientifi c Library reporter Walkholz surveys promising can help. breakthroughs in the labs where basic Each time we present a fi lm in the SciLib Theatre Science in the Cinema science takes place. series, we purchase the videotape for our circulating collection. We also videotape the follow-up, where our guest speakers lead discussion on fascinating Deadly Feasts: Tracking the Secrets topics relating to the fi lms. To date, we have 13 movies: of a Terrifying New . Richard Rhodes. WL300.R477 1997. Rhodes, Film Date Speaker Topic a non-fi ction writer, doesn’t miss a Medicine Man 1992 Dr. Gordon Cragg Natural Products beat in his disturbing story about the Outbreak 1995 Dr. David Franz Biohazards terrifying specter of emerging prions, Gattaca 1997 Dr. Mike Dean Genetics igniting a national debate about Lorenzo’s Oil 1992 Dr. Mike Dean Drug Development food safety. The Doctor 1991 Kathy Higinbotham Being a Patient Madame Curie 1943 Dr. Sally Spence Women Scientists Deadly Medicine : Why Tens of Philadelphia 1993 Dr. John Coffi n AIDS Thousands of Heart Patients Died in A Beautiful Mind 2001 Dr. Amar Klar Schizophrenia America’s Worst Drug Disaster. The Light in the Jungle 1992 Philip Roessler Albert Schweitzer Thomas J. Moore. QV150.M824d Desk Set 1957 M.J. Tooey Libraries & Computers 1995. In exploring how this disaster Regarding Henry 1991 Seldon Cooper Brain Injury evolved, the author questions how Never Cry Wolf 1983 Mike Nickerson Arctic Environments researchers test drugs, what companies Wit 2001 Kitty Nalewaik Ovarian Cancer do to sell them, and what doctors do and don’t know about the drugs they Before the fi rst snowfl ake falls, we hope to have received all of the companion prescribe and we consume. books which prompted these movies; for example, A Beautiful Mind, by Sylvia Nasar; Madame Curie, A Biography, by Eve Curie; Never Cry Wolf, by Farley : A True Mowat; and Schweitzer, A Biography, by George Marshall and David Poling. Story. . WC585.P939 To complement this singular collection, we have over 300 videotapes, among 2002. Journalist Preston covers the which may be found: The Real Science Behind the X-Files, More Real Science history of and the heroic Behind the X-Files, Why I Should Stay Awake in Science Class, an exciting campaign to eradicate the disease, selection of Nova and PBS broadcasts (many of which address the work of including a discussion of the frozen scientists here at NCI-Frederick), and most intriguing of all, Puss in Boots, stores of the virus and the potential for Adventures of the Library Cat, which investigates cat mascots that live in biological warfare. libraries throughout the United States. There is also a hefty selection of health and wellness videos in our Center for Health Information collection—just what Dr. Folkman’s War: Angiogenesis you’ll need to help you pursue those New Year’s resolutions. and the Struggle to Defeat Cancer. Robert Cooke. QZ267.C773 2001. Also consider taking advantage of our Reading Diversions series, the Library’s The story of Judah Folkman’s work on distinguished selection of books that talk about science in an entertaining the formation of blood vessels and its or provocative way. You can fi nd the entire list on our Web site, at http: application to the treatment of cancer. //www-library.ncifcrf.gov. Once there, click on Online Catalog, then Reading Diversions. Here is a selection of titles you’ll fi nd: Ebola Through the Eyes of the People. William T. Close. WC 534.C645 2002. Big Shot: Passion, Politics, and the Struggle for an AIDS Vaccine. Congo physician and surgeon Close Patricia Thomas. WC503.2.T461 2001. A veteran journalist dramatizes the tells the compelling story of death controversial search for an AIDS vaccine, the players, politics, and money, in a and true heroism of the real doctors, story that reveals how science is done and not done in America today. nurses, and victims of this disease.

The NCI-Frederick Poster 22 November 2003 Wilson Information Services Corporation (WISCO)

The Emperor of Scent: A Story of The Science of Cooking. Peter Barham. Typhoid Mary: Captive to the Public’s Perfume, Obsession, and the Last TX 651.B147 2001. Revealing that Health. Judith Walzer Leavitt. WC Mystery of the Senses. Chandler Burr. the kitchen is no different from most 270.L439 1996. The defi nitive book WV 301.B968 2002. Burr, who has science laboratories, Barham unravels on the life of Mary Mallon, who over made a hobby of collecting fragrances, the mysteries of the “art” of good seven years infected almost fi fty published a collection of his reviews cooking. people, presenting a picture of early- and in so doing solved the puzzle of 20th century New York. how smell works, hitting the insular The Social Life of Information. John business of perfume makers like Seely Brown And Paul Duguid. Virus: The Co-Discoverer of HIV a thunderclap. Z 699.B878 2002. Deemed by Tracks its Rampage and Charts the the Financial Times as one of the Future. Luc Montagnier, translated. Human Wildlife: The Life That Lives best-read books of the Internet QW 168.5.H6 M758 2000. French On Us. Robert Buckman. QX 45.B925 age, this tome discusses the impact virologist Montagnier discusses 2002. Your body has 100 trillion cells, of technology on the workplace, his work in identifying HIV in a only 10 trillion of them human; the communities, and life in general. combination scientifi c detective story rest belong to , fungi, viruses, and memoir. and parasites that live on and in us. The Speckled Monster: A Historical Tale of Battling Smallpox. Jennifer So on those mornings when the Medicine Quest: In Search of Nature’s Lee Carrell. WC 588.C314 2003. The radio announcer forecasts snow, Healing Secrets. Mark J. Plotkin; dramatic story of two parents who plan to drop by the Library on your illustrations by Laurence Richardson. dared to fi ght back against the disease way to the offi ce to stock up on your QV 752.P729 2000. Apprentice to after barely surviving it themselves, entertainment supplies. Remember to shamans, ethnobotanist Plotkin, who fl outing 18th century European buy popcorn along with your bread, works with indigenous peoples to medical tradition. milk, and toilet paper at the grocery document their uses of local plants, store on the way home. Ø describes the search for miraculous The Surprising Archaea: Discovering new medicines from Mother Nature. Another Domain of Life. John L. Howland. QW 50.H864 2000. An The River: A Journey to the Source account of the exotic attributes and of HIV and AIDS. Edward Hooper. evolutionary implications of Archaea, WC 503.41.H785 1999. Based on ancient microorganisms that consume over 600 interviews and extensive carbon dioxide instead of oxygen and library research, this history of the release methane into the atmosphere. AIDS epidemic raises questions about the inquiry into the origins of the disease. It is long enough for a record- breaking blizzard.

Science Fictions: A Scientifi c Mystery, A Massive Coverup and the Dark Legacy of Robert Gallo. John Crewdson. WC 503.C74 2002. Pulitzer Prize-winning journalist Crewdson (The Tarnished Door) provides a comprehensive and compelling examination of the controversy surrounding the discovery of the AIDS virus.

The NCI-Frederick Poster 23 November 2003

The Poster Staff Job Openings

Executive Editor Paul Miller SAIC-Frederick, Inc. Associate Editor Ken Michaels Animal Caretaker I: positions require Research Associates (various Managing Editor completion of 8th grade and the ability laboratories): positions require BS Maritta Grau to lift and carry up to 50 lbs. degree or equivalent plus 4 years of Production Editor related biomedical experience. Kathy Green Research Technicians (various Lead Designer laboratories): positions require BS Clinical Research Associates (various Tammy Schroyer Photography Editors degree or equivalent (4 years) related levels), Clinical Monitoring Research Jonathan Summers biomedical research experience. Program: positions require minimum Marti Welch of BS degree (preferably in a scientifi c Sr. Research Technicians (various discipline, BSN, or pharmacy) and a Contributing Editors laboratories): positions require BS minimum of 2 years directly related degree or equivalent plus 2 years of experience overseeing multiple Administrative Resource Center related biomedical experience. concurrent clinical trials. Carrie Jennings Carolynne Fitzpatrick For a complete listing of all open Tanya Sappington positions, or to apply for posted Charles River Laboratories openings, please visit our Web site at: Cliff Hubbard http://saic.ncifcrf.gov Community Outreach Barbara Birnman Data Management Services Jim Racheff Environment, Health, and Safety Program Carol Ingraham-Tobias Facilities Maintenance and Engineering Research and Training Opportunities Deborah Dobbe Please contact the individual contractor’s human resources representative Frederick Employee Diversity Team or go to the contractor’s Web site for up-to-date, detailed information and Scott Keimig job requirements. McKesson BioServices Kathleen Groover Patricia Hindes Charles River Laboratories SAIC-Frederick, Inc. http://www.criver.com Dave Bufter Science Today Data Management Services Steve Giardina http://css.ncifcrf.gov/about/dms.html Wilson Information Services Corporation National Cancer Institute at Frederick Sue Wilson http://www.training.nih.gov/postdoctoral Robin Meckley SAIC-Frederick, Inc. Published four times a year by Scientifi c http://saic.ncifcrf.gov Publications, Graphics & Media for the National Cancer Institute at Frederick, Frederick, MD 21702. Wilson Information Services Corporation http://web.ncifcrf.gov/ThePoster http://[email protected]

The National Cancer Institute

Frederick, MD 21702-1201 ShuttleScience ServiceToday

Everything You Wanted to Know about the Protective Services Passenger Shuttle Service (But Were Afraid to Ask)

1. The shuttle to the National Institutes of Health (NIH) has four trips daily, Monday–Friday (see schedule below). 2. The shuttle stops at NIH Buildings 45, 31, and 10. 3. Passengers may be transported while conducting offi cial Government business only. Transportation for non-offi cial passengers (spouses, children, etc.) in a Government-owned vehicle is prohibited. 4. Passengers are prohibited from carrying biological, chemical, or radiological packages onto the shuttle. 5. The shuttle leaves the parking lot of Building 426, NCI-Frederick, at the exact time specifi ed. 6. Excluding inclement weather conditions and depending on traffi c, the shuttle will arrive at each destination approximately fi ve minutes before its next departure time. 7. The shuttle leaves each NIH building at the exact time posted on the schedule. 8. In the event of inclement or pending inclement weather conditions, the shuttle run may be canceled. Call x1091 to verify shuttle status.

Protective Services Passenger Shuttle Service Schedule

Run # NCI- NIH NIH NIH NCI- Frederick Bldg. Bldg. Bldg. Frederick Bldg. 426 45 31 10 Bldg.426 Leave Leave Leave Leave Arrive

1 7:00 AM 8:20 AM 8:25 AM 8:30 AM 9:20 AM

2 9:55 AM 10:45 AM 10:50 AM 10:55 AM 11:45 AM

3 12:30 PM 1:20 PM 1:25 PM 1:30 PM 2:20 PM

4 3:30 PM 4:20 PM 4:25 PM 4:30 PM 5:35 PM

Points of Departure NCI-Frederick: Building 426, Main Entrance

NIH: Building 31A, Main Entrance Building 10, South Entrance Building 45, Main Entrance

*NNMC: Navy Medical Center, Wisconsin Avenue Side (* by request only, 301 846-1091)

Note: Shuttle bus arrives fi ve minutes prior to departure. Shuttle bus will depart at the exact time posted. Ø

Dave White has served as the shuttle bus driver for 10 years. Weather Advisory

You peer out the bedroom window and see softly falling snow or the gleam of ice. Is the base closed? Here’s how to fi nd out. Call the Fort Detrick Telenews (301-619-7611), listen to local radio/television stations, or contact the Frederick News Post Sound Source for information.

Closing or Delayed Opening Remember: When Fort Detrick is closed, NCI-Frederick is also closed; when Fort Detrick has a delayed opening, NCI- Frederick has a delayed opening. NCI-Frederick does not follow weather closing or delayed opening advisories for the NIH-Bethesda campus or Washington metropolitan area.

Early Dismissal For early dismissal, NCI-Frederick operates independently of Fort Detrick; therefore, your supervisor will notify you if NCI-Frederick closes during work hours.

Who Ya Gonna Call?

Telephone Recorded weather line 301-619-7611 Ft. Detrick toll free number 1-800-256-7621, *8, 37611#” TDD 301-619-2293 Sound Source weather line 301-695-2633, press 3801 (recorded line)

Internet (This will only be used if there is a change in operating hours.) Fort Detrick’s home page: http://detrick.army.mil/. Weather information pops up automatically.

Radio/TV

Frederick, MD Williamsport, MD Charles Town, WV WAFY FM/103.1 WCRH FM/90.5 WMRE AM/1550 WFMD AM/930 WXVA FM/98.3 WFRE FM/99.9 Chambersburg, PA WCHA AM/800 Arlington, VA Hagerstown, MD WIKZ FM/95.1 WWVZ FM/103.9 WARK 1490 WWZZ FM/104.1 WARX 106.9 Gettysburg, PA WJEJ AM/1240 WGET AM/1320 Washington, DC WWMD FM/101.5 WGTY FM/107.7 WTOP AM/1500 WHAG AM/1410 WMZQ 1390/98.7 WQCM FM/96.7 Mercersburg, PA WRQX FM/107.3 WHAG TV/Ch. 2 WSRT FM/104.7

Baltimore, MD Greencastle, PA WBAL AM/1090 WHGT AM/1380 WIYY FM/97.9 WAYZ FM/104.7 WPOC FM/93.1 WCAO AM/600 Martinsburg, WV B104.3 FM/104.3 WEPM AM/1340 WJZ TV/Ch. 13 WLTF 97.5

Thurmont, MD WTHU AM/1450