The National Cancer Institute at Frederick

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Outstanding Mentors WINTER 2006–2007

What Makes an Outstanding Mentor? IN THIS ISSUE by Maritta Perry Grau Encouraging Young Scientists 4 “The day you accept a student or postdoc, you become a mentor,” Science Today 6 said Dr. Andrew Byrd, chief of the Structural Biophysics Laboratory, Platinum Publications 8 Center for Cancer Research Poster People Profi le 10 (CCR), at NCI-Frederick. Dr. Byrd and two other CCR Christopher J. Michejda 11 colleagues were among 11 scientists that NCI recently Science Communications 12 recognized for their excellent mentoring skills. Dr. William Outreach and Special Programs 13 Farrar, head of the Cancer Stem Second from right, Dr. William Farrar, Head, Cell Section, Laboratory of Cancer Stem Cell Section, Laboratory of Protective Services 14 Cancer Prevention, received Cancer Prevention, CCR, with mentees. an Outstanding Mentor Award. Open Houses 15 Dr. Byrd and Dr. Alexander for their commitment to fostering the Wlodawer, chief, Macromolecular independent careers of their fellows, Books for Mongolia 16 Crystallography Laboratory, received students, and trainees. According to Frederick Employee Diversity Mentor of Merit awards. Dr. John Niederhuber, NCI director, Team 17 Created in 2001, the Mentoring “Each of this year’s Mentor honorees Awards recognize NCI investigators continued on page 2 New Faces at NCI-Frederick 18 Employee Assistance Program NCI-Frederick People 19 The Poster Puzzler 20

Employee Assistance Program Now Offers Legal and Poster Puzzler Winner 21 Financial Consultation and 24/7 Coverage PALS’ Celebrations 22 by Nancy Parrish Technology Transfer Branch 23 The new Employee Assistance employee assistance plans, the new Program, introduced in September, program offers a network of more than Charles River Laboratories 24 offers all NCI-Frederick government 7,000 licensed counselors to assist and contractor employees a new employees and dependents with issues Data Management Services 25 network of counselors as well as legal that may affect their ability to work to and fi nancial consultation. full potential. In addition to counseling SAIC-Frederick, Inc. 26 Administered by Business Health on personal and work-related issues, Wilson Information Services Services (BHS), a nationally the program now offers assistance on Corporation 27 recognized company with over issues related to personal fi nance and 20 years’ experience in providing legal matters. Employment Opportunities 28 continued on page 3 Outstanding Mentors continued from page 1 exemplifi es the excellent leadership recommendation, and nominates the independent work and who taught me and staff that make up NCI, and I trainee for awards or other recognition. a lot about how to mentor others.” congratulate them for this recognition Dr. Farrar explained, “Generally, Dr. Byrd said that both high school and for the key roles they play in I establish research goals, provide and university teachers encouraged his creating the well-trained, highly the means, and design experiments. interest in science. “Professors Don motivated scientists of our future.” I help with writing. In turn, I expect Kubler and William Harris [Furman responsibility and accountability. I ask University] instilled in me a respect PI Expected to Mentor [post-docs/students] what they wish for research and an excitement in All principal investigators are to achieve and in what employment truly enjoying research and science…. expected to mentor, although there is sector they wish to have a career. I In graduate school, professors Paul no formal training. Dr. Byrd explained, think it is important that they work Ellis, Jerry Odom, and Bruce Dunlap on something that makes them highly [University of South Carolina] were eligible for the next step in their so enthusiastic and involved… that it careers. My goal is to minimize their was impossible not to be enthusiastic weaknesses and expand their strengths and motivated to achieve. They also to make them highly competitive at enabled me to meet… future Nobel their next career stop.” Prize winners Richard Ernst and Kurt Dr. Byrd observed, “Mentoring is not a scheduled activity, it is the activity of science... Every interaction with a group member is mentoring. A natural outgrowth of this interaction is the discussion and development of their career plans, [encouraging] the person to become involved with the scientifi c Dr. Andrew Byrd, Chief, Structural community and to be aware of the Biophysics, CCR [excitement in learning about] that fi eld. The reward for this investment “How well you do is directly related in time with each person is watching to how well you establish mutual them mature scientifi cally.” respect and use your experience to Mentors Learned from foster the relationship, to encourage Dr. Alexander Wlodawer, Chief, the person, and to take pride in their Their Own Mentors Macromolecular Crystallography accomplishment rather than dwelling These mentors themselves were once Laboratory, CCR only on how the work benefi ts you.” trainees. Dr. Farrar said that one of his While an intern may be mentored earliest mentors had “great integrity Wüthrich, as well as to interact with for only one summer, a postdoctoral and made science a fun adventure.” other scientists who have helped me fellow might work with his mentor Dr. Wlodawer noted that he had since coming to the NIH, e.g., Drs. Ira fi ve or more years. Dr. Farrar learned much from his graduate Levin and Ted Becker [NIDDK, NIH].” commented, “Many have gone on to advisor, Dr. David Eisenberg, Dr. Farrar, Dr. Byrd, and Dr. be departmental chairs; these are my Associate Director of the Institute for Wlodawer all strongly advocate greatest career accomplishments.” Genomics and Proteomics at UCLA, mentoring as an important part of the one of the best known structural principal investigator’s work ethic. “It Mentoring: the Activity biologists in the United States; and is my duty to help them in establishing of Science from another mentor, Dr. David themselves as fully independent, The mentor suggests research topics, Davies, Chief, Section on Molecular tenured investigators,” Dr. Wlodawer reviews results, helps in writing Structure, Laboratory of Molecular commented. Dr. Byrd concluded, “I papers and posters, encourages the Biology, the National Institute of strongly feel that the success we have trainee to attend conferences, advises Diabetes and Digestive and Kidney as scientists is infl uenced by the people about job prospects, writes letters of Diseases [NIDDK], “in whose we work with as well as the physical laboratory I started my own fully opportunities that we have.” Ø

The NCI-Frederick Poster 2 Winter 2006–2007 Employee Assistance Program continued from page 1 Services are available by calling 1- Telephone counseling is available For More Information 800-765-3277, 24 hours a day, 7 days through TTY and in 130 languages a week. The call will be answered through a translation service. For more information, call by a Masters’-level clinician, or Counseling is free and confi dential. Occupational Health Services at care coordinator, who can assess Counseling services are available at 301-846-1096 or the Business Health needs, monitor progress of the case, no charge to all employees and their Solutions toll-free number, 1-800-765- and ensure that appropriate help is dependents. Callers will be treated 3277. Or, you may visit the NCI- received. The care coordinator then with the same confi dentiality as they Frederick Web site (http://web.ncifcrf. handles all future calls. would fi nd at their doctor’s offi ce: no gov/news/NCIF%20Premier%20New Legal consultations cover any information will be released without sletter2.pdf), or log on to the Business legal issue you or your dependents written consent. Health Solutions Web site, www. may be facing. Examples include bhsonline.com, and enter NCIF as the estate planning, domestic/family Other Services Available user name. Ø matters, motor vehicle violations, The new program provides access real estate concerns, landlord/tenant to the BHS Web site, with its on-line New EAP Services disputes, IRS and business matters, resource library containing thousands at a Glance even criminal charges. You and of articles related to health and well- your dependents may speak with a being, legal, fi nancial, small business • Free and confi dential qualifi ed legal professional by phone and personal growth issues. The Web • Available 24 hours a day, or in person, for up to 30 minutes at site also includes Solution Centers, 7 days a week, 365 days a year no charge, per problem episode, per which are designed to lead you or • Offers counseling for personal year. If additional legal consultation your dependents through problems and work-related issues is needed, it may be continued at a related to specifi c life issues, such as • Includes legal and fi nancial discounted rate. adoption, buying a home or car, elder consultation Financial consultations are care, creating a will, and many more. • TTY accessible; 130 languages available on such issues as budgeting, spoken college funding, retirement funding, On-site Counselor Will Remain • Available to all NCI-Frederick credit counseling, debt management/ The on-site counselor, Selden government and contractor consolidation, estate planning, Cooper, will continue to be available employees, legal spouses, and and tax preparation. You and your for counseling sessions on Tuesdays, dependent children dependents may speak with a BHS- Wednesdays, and Fridays. You may qualifi ed fi nancial specialist for up to request an appointment with him when Call 1-800-765-3277 60 minutes at no charge, per problem you call the BHS toll-free number, Log on to www.bhsonline.com Ø episode, per year. If further advice is 1-800-765-3277. [User name: NCIF] necessary, a referral may be made to a local resource.

The NCI-Frederick Poster 3 Winter 2006–2007 Encouraging Young Scientists

Education Summit: quoting Nelson Mandela: “Education org/pisa), one section of which tested Greater Science is the most powerful weapon we can problem-solving skills among students Training Needed use to change the world.” from 40 countries. Dr. Fuchs pointed By Maritta Perry Grau The Department of Defense (DOD) employs about 50% and in some areas, up to 90%, of the scientists and engineers working in the United States, according to Keith Thompson, Offi ce of the Secretary of Defense, DoD. Mr. Thompson, speaking at an education summit conference in November sponsored by the National Interagency Confederation for Biological Research, noted that as these workers are ageing, fewer and fewer are replaced each year, with the result that many technical laboratories have fewer students each year with clearance security for critical placements such as in BSL3 laboratories. Nearly all the speakers focused on the need for more science and Programme for International Student Assessment 2003 (Web site http://www.oecd. org/pisa), one section of which tested problem-solving skills among students from 40 countries, ranked the United States 29th.

Dr. Bruce Fuchs, Director, Offi ce of out the U.S. was 29th, ranked below Science and Education at NIH, stated most of the countries that are its that U.S. education is “in a Sputnik economic partners and competitors, kind of era,” referring to years when such as Japan (#4), Canada (#8), the then-Soviet Union sent fi rst, a France (#12), Germany (#16), and the Sputnik satellite, and then, Russian Federation (#28). cosmonaut Yuri Gagarin Great Britain was not to orbit the earth. This listed. “one-upsmanship” led to a As part of encouraging vigorous emphasis on math students to seek careers and science in U.S. public in science fi elds, speakers education, resulting in the also addressed the need NASA space program and for internships and math education in both public America’s famed walk on mentors. Barbara Birnman, schools and universities, as well as the moon July 21, 1969. Outreach and Special internships in business and science- According to Dr. Fuchs, Programs Coordinator, related organizations. Major General the future U.S. workforce— NCI-Frederick, discussed Eric Shoomaker, M.D., Ph.D., today’s teenagers—are the many facets of the Commanding General of the U.S. “sadly lacking in problem- Werner H. Kirsten Student Army Medical Research and Materiel solving skills.” To Internship Program Command and Fort Detrick, perhaps illustrate, he showed statistics from the (SIP), which draws students from the said it best when he set the tone of the Programme for International Student Frederick and Washington County conference in his welcoming remarks, Assessment 2003 (http://www.oecd. public school systems, St. John’s

The NCI-Frederick Poster 4 Winter 2006–2007 Encouraging Young Scientists

Literary Institute at Prospect Hall in Members of the National Interagency Frederick, and the Jefferson County Confederation for Biological Research Public School System, West Virginia. include the National Cancer Institute, Since 1990, 431 students have the National Institutes of Health, the successfully completed SIP; this year’s Department of Homeland Security, the 62 students comprise the largest class Department of Agriculture, the Centers yet. In addition, with the Employee for Disease Control and Prevention, Outreach Program, during the past 8 and the U.S. Army Medical Research years, more than 350 NCI-Frederick and Materiel Command. Ø employees have volunteered over 8,000 hours to teach science lessons to more than 13,000 elementary-aged students. Dr. Donna Vogel, then of the Ellison Medical Foundation, Bethesda, focused on the characteristics of mentoring [see our lead article on mentoring awards, page 1]: A mentor must provide open communication;

help the mentee develop presentation skills needed in writing, creating posters, teaching, making grant applications, and competing for SIP Broadens Its Horizons awards; and help the mentee develop visibility through involvement in site For several years, the Werner H. internships in other fi elds in support visit preparation. “There’s no substitute Kirsten Student Intern Program of science and research will also be for getting known,” she said. Such (SIP) has reached beyond the available for the 2007–2008 school visibility, she said, “opens the doors to boundaries of Frederick County into year. Applications were sent to the neighboring Washington County. school systems in early November. collaborations and job opportunities.” Now the program is crossing If you know any high school The mentor should encourage state lines, too. In response to a juniors who are interested the mentee to search out career request from interested parents, in applying for the program, opportunities by developing his/her Jefferson County, West Virginia, encourage them to contact their résumé and participating in interviews. will participate in the program school transition coordinator for A mentor has to learn to let go, not to beginning in 2007. Jefferson County applications. Additional information make the trainee into a clone. High School has more than 2,000 on our internships and a listing Finally, she said, “If we do it right, the students, who will join Frederick of school transition coordinators trainee is not a threat but a compliment County, Washington County, and may be found at http://web.ncifcrf. to the mentor’s career…When our St. John’s at Prospect Hall students gov/careers/student_programs/ students look good, we look good.” in competing for internships. In internships/SIP.asp. Ø addition to scientifi c positions,

The NCI-Frederick Poster 5 Winter 2006–2007 Science Today

There Is More to Searching Web of Science the results into three tabbed sections: than PubMed! SCOPUS, Web, and Patents. SCOPUS By Robin Meckley, The multidisciplinary Web of Science also provides some cited reference Instructional Resources Librarian combines the Science Citation Index searching and ranks various fi elds in Scientifi c Library and Social Sciences Citation Index terms of numbers of references within and provides access to journal articles a search. When you plan to buy a new car, you and meetings proceedings in scientifi c visit various car dealerships, either in subjects, including biology, chemistry, NIH OVID Databases person or online, gathering information mathematics, medicine, and veterinary The multidisciplinary NIH OVID to fi nd just the right car. Even after you science, as well as social scientifi c databases offer access to several choose a specifi c model, you may still subjects such as history, psychology, databases, indexing journals, meeting further refi ne your search, looking for public health, and sociology. Web proceedings, patents, and books: color and all the extras. of Science indexes more than 7,600 AGRICOLA (National Agricultural You should do the same thing when journals and meetings proceedings Library), Biological Abstracts (life searching for information—whether from 1955 to the present. It offers sciences), CINAHL (nursing and on a specifi c author, about a specifi c cited reference searching, allowing allied health), Health & Psychosocial disease, or for an article you are the searcher to learn who has cited a Instruments (information on writing. Search various bibliographic particular article since its publication. measurement instruments that may databases. At the National Cancer The newest version can analyze a group help with papers, dissertations, and Institute at Frederick (NCI-Frederick), of records, letting the searcher generate grant proposals), and PsychINFO most of us search PubMed, the a ranked list of authors who publish (psychology). The subject and year free bibliographic database from on a particular subject, with the most coverage of the NIH OVID databases the National Library of Medicine prolifi c authors at the top of the list. varies with each database. The system (NLM) and the National Center for allows simultaneous searching of Biotechnology Information (NCBI) EMBASE multiple databases, and easy transfer that covers biomedical literature, EMBASE, the electronic version of of search strategies from one database including clinical medicine, life the print European index Excerpta to another. sciences, nursing, and dentistry. But, Medica, is a biomedical database with as good as PubMed is, it does not very strong pharmacological coverage, Chemical Abstracts on CD cover meeting proceedings, patents, providing access to journal articles Chemical Abstracts on CD (CA on dissertations, books, or reports; or all and meeting proceedings, including CD), an American Chemical Society scientifi c journals. There is more to European journals that may not be database, is available on CD-ROM searching than PubMed! covered in other databases. EMBASE only through the Library’s server. In addition to PubMed, you can indexes more than 4,500 international Instructions on connecting to the access several other databases at the journals from 1966 to the present. server are available from our Web site. Scientifi c Library’s Web site, http:// Searchers who access EMBASE can, CA on CD indexes more than 875,000 www-library.ncifcrf.gov. Although at the same time, search the database items annually, covering chemical you do not need a password, you must MEDLINE, one source of PubMed. journals, patents, dissertations, and access these databases through an technical reports from 1992 to the NCI-Frederick computer. To access SCOPUS present. You can search unique fi elds the databases from home or when you The large multidisciplinary database, such as patent numbers, formulas, and are traveling, use the library’s off- SCOPUS (Elsevier Science), provides compound names. site access method, which requires access to scientifi c, medical, technical, a library barcode. More information and social scientifi c subjects. It Beilstein about off-site access is available from simultaneously searches EMBASE, Beilstein is another chemical the library’s Web site. patents, and SCIRUS, a unique database available from only one scientifi c Web browser. SCOPUS computer in the Scientifi c Library. indexes more than 14,000 international There is no access via the Web. journals, meeting proceedings, books, Beilstein is a very large German book chapters, patents, and Web sites database that indexes thousands of from 1960 to the present, organizing chemicals from 1771 to the present,

The NCI-Frederick Poster 6 Winter 2006–2007 Science Today making it the only database that goes in-Print indexes journals, meetings Manager, software that can eliminate back centuries! It provides complete proceedings, books, and book chapters duplicates. However, if you don’t information on chemical properties from 1997 to the present. While the have the time or feel you don’t have and permits substructure searching. database currently runs on a Reference enough knowledge to search, let us Manager Web platform, staff is help. The Scientifi c Library staff can NCI-Frederick-in-Print updating the software to a more user- search for you and give you the results NCI-FREDERICK-in-Print is friendly interface. in whatever format you require. Just a unique database created and Now that you have learned about complete a Computer Search Request maintained by the staff of the other databases, try your hand at Form at http://www-library.ncifcrf. Scientifi c Library. To be included searching. We encourage you to search gov.ezlib.ncifcrf.gov/searchform.aspx. in the database, at least one author as many databases as you can. You of the publication must work at will fi nd unique, helpful information. Remember: There is more to NCI-Frederick, or did at the date Many of these databases allow direct searching than PubMed! Ø of publication. NCI-FREDERICK- exporting to EndNote or Reference

Quick Reference Guide for Scientifi c Library’s Bibliographic Databases Most available via Scientifi c Library’s Home Page: www-library.ncifcrf.gov Ø

Beilstein Chemical Abstracts on CD EMBASE NCI-FREDERICK-in-Print Chemical coverage Chemical coverage Biomedical & pharmacological Only authors from NCI- Patents, journals, properties, Patents, dissertations, reports, coverage Frederick Meetings, journals structures journals Meetings, journals 1997–present 1771–present 1992–present 1966–present Items unique to NCI-F Keywords, formulas, 875,000 items yearly 4500+ journals Keywords compounds Keywords, formulas, EMTREE & keywords No related documents Allows substructure searching compounds “Related Articles” No document delivery No related documents No related documents No document delivery Some full-text links No document delivery No document delivery Full-text links No Alerts No full-text links No full-text links “E-Mail Alert” No cited reference searching No Alerts No Alerts No cited reference searching All authors/all addresses No cited reference search No cited reference search Most authors/only 1st author’s All authors/all addresses All authors/all addresses address

NIH OVID PubMed SCOPUS Web of Science Multidisciplinary coverage Biomedical coverage Multidisciplinary coverage Multidisciplinary coverage Patents, meetings, books, Journals Patents, web references, Meetings, journals journals 1950–present books 1955–present Years depend on database 5000+ journals 1960–present 7600+ journals Journals depend on database MeSH & keywords 14,000+ journals Keywords Keywords & controlled “Related articles” Keywords “Related records” words Loansome Doc “Related documents” “Order Documents” “Find Similar” Full-text links No document delivery Full-text links No document delivery My NCBI Full-text links PORPOISE Full-text links No cited reference searching “Save as Alert” Cited reference searching “Save Search/Alert” Most authors/only 1st Citation Tracker All authors/all addresses No cited reference searching author’s address All authors/all addresses All authors/only 1st author’s address

The NCI-Frederick Poster 7 Winter 2006–2007 Platinum Highlight

Chandravanu Dash, Ph.D. During the HIV-1 life cycle, the interference to examine its effect on Postdoctoral Fellow multifunctional reverse transcriptase HIV-1 RT’s ability to function as HIV Drug Resistance Program (RT) converts the single-stranded a DNA polymerase, Dr. Dash and viral RNA genome to double-stranded his colleagues have demonstrated DNA, which integrates into the host that “altering the topology of the genome and allows production of template two nucleotides ahead of the components needed to generate the catalytic center [of RT] interrupts infectious virions. According to Dr. polymerization by stalling the Dash, Dr. Le Grice’s lab studies replication complex.” In addition, the how RT from HIV and related specifi c physical interaction between lentiviruses, including those of simian, HIV-1 RT amino acid Phe-61 and the equine, and feline origin, process the nucleic acids ahead of the catalytic conformationally distinct nucleic acids center of the enzyme plays a key they encounter during viral replication. role during polymerization. Dr. Dash Ultimately, he said, this research is noted, “Our unique experimental signifi cant in developing antiviral strategy allows us to investigate other therapies because “HIV-1 RT remains a amino acids of HIV-1 RT that are prime target in the development of drugs proposed to interact with the template Dr. Chandravanu Dash’s interest to inhibit virus replication and stem the during reverse transcription.” in HIV research began during his devastating consequences of AIDS.” Dr. Dash added, “It is essential graduate studies at India’s National Previous studies have investigated to obtain detailed mechanistic Chemical Laboratory (NCL). After the geometry of duplex nucleic acids information about HIV-RT for the receiving his Ph.D. in biochemistry positioned between the catalytic continued development of effective from the NCL in 2002, Dr. Dash centers of HIV-1 RT, yet how the antiviral drugs and for targeting drug- joined the laboratory of Dr. Stuart Le single-stranded template traverses resistant viruses. This information Grice in the Resistance Mechanisms the fi ngers sub-domain prior to may also help to eventually utilize the Laboratory, HIV Drug Resistance accessing the DNA polymerase secondary structure of nucleic acids as Program, NCI-Frederick, where he is catalytic center was not well an alternative approach to drug target currently a postdoctoral fellow. understood. Using nucleoside analog development.” Ø

Chandravanu Dash, Timothy S. Fisher, Vinayaka R. Prasad, Stuart F. J. Le Grice the catalytic center can interrupt DNA synthesis. Mutating Phe61 to either Examining Interactions of HIV-1 Reverse Transcriptase Ala or Leu accentuates this defect, with Single-stranded Template Nucleotides while replacement with Trp allows the by Nucleoside Analog Interference mutant enzyme to bypass the template J Biol Chem 281(38):27873–27881, 2006 analogs with relative ease. Ø

Crystallographic studies have affect the polymerase function implicated several residues of the of HIV-1 RT. Analogs included p66 fi ngers subdomain of human abasic tetrahydrofuran linkages, immunodefi ciency virus type-1 reverse neutralizing methylphosphonate transcriptase (HIV-1 RT) in contacting linkages and conformationally- the single-stranded template overhang locked nucleosides. In addition, immediately ahead of the polymerase several fi ngers subdomain catalytic center. This interaction is mutants of Phe61 residue were presumably important for effi cient and included, based on previous accurate incorporation of the incoming data indicating that altering this This fi gure presents data from, but is not dNTP. To investigate this, we residue affects DNA synthesis. included in, the featured publication. introduced nucleoside analogs into the We demonstrate here that altering To access the complete article, please DNA template ahead of the catalytic the topology of the template visit http://www.jbc.org/cgi/content/ center and investigated whether they strand two nucleotides ahead of full/281/38/27873. Ø

The NCI-Frederick Poster 8 Winter 2006–2007 Platinum Publications

The following 19 articles have been selected as a model for the double knock-out of involved in AMPK and mTOR signaling. from publications in nine of the most prestigious slc5a8 and slc5a12 in kidney. J Biol Chem Proc Natl Acad Sci USA 103(42):15552– science journals. 281(37):26769–26773, 2006. 15557, 2006. Cell, Tumor, and Stem Molecular Basis of Cell and Cell Biology Warming S, Rachel RA, Jenkins NA, Copeland NG. Zfp423 is required for Developmental Biology Mani A, Oh AS, Bowden ET, Lahusen normal cerebellar development. Mol Cell Lammerding J, Fong LG, Ji JY, Reue K, T, Lorick KL, Weissman AM, Schlegel Biol 26(18):6913–6922, 2006. Stewart CL, Young SG, Lee RT. Lamins R, Wellstein A, Riegel AT. E6AP medi- A and C but not lamin B1 regulate nuclear ates regulated proteasomal degradation of Glycobiology and mechanics. J Biol Chem 281(35):25768– the nuclear receptor coactivator amplifi ed Extracellular Matrices 25780, 2006. in breast cancer 1 in immortalized cells. Helle F, Wychowski C, Vu-Dac N, Gus- Neoplasia Cancer Res 66(17):8680–8686, 2006. tafson KR, Voisset C, Dubuisson J. Cya- Rudelius M, Pittaluga S, Nishizuka S, Epidemiology and Prevention novirin-N inhibits hepatitis C virus entry by binding to envelope protein glycans. J Pham THT, Fend F, Jaffe ES, Quinta- McGlynn KA, Abnet CC, Zhang MD, Biol Chem 281(35):25177–25183, 2006. nilla-Martinez L, Raffeld M. Constitutive Sun XD, Fan JH, O’Brien TR, Wei WQ, activation of Akt contributes to the patho- Ortiz-Conde BA, Dawsey SM, Weber Sakamoto K, Ito Y, Mori T, Sugimura K. genesis and survival of mantle cell lympho- JP, Taylor PR, Katki H, Mark SD, Qiao Interaction of human lactoferrin with cell ma. Blood 108(5):1668–1676, 2006. YL. Serum concentrations of 1,1,1-Tri- adhesion molecules through RGD motif chloro-2,2-bis (p-chlorophenyl)ethane Oncogene elucidated by lactoferrin-binding epitopes. (DDT) and 1,1-Dichloro-2,2-bis (p- Ishimura A, Lee HS, Bong YS, Saucier J Biol Chem 281(34):24472–24478, 2006. chlorophenyl)ethylene (DDE) and risk of C, Mood K, Park E, Daar IO. On- primary liver cancer. J Natl Cancer Inst HIV cogenic Met receptor induces ectopic 98(14):1005–1010, 2006. Hatziioannou T, Princiotta M, Piatak M, structures in Xenopus embryos. Oncogene 25(31):4286–4299, 2006. Previously includ- Enzyme Catalysis and Yuan F, Zhang FW, Lifson JD, Bieniasz PD. Generation of simian-tropic HIV- ed as an “[Epub ahead of print]” reference. Regulation Article is now available in the print journal. 1 by restriction factor evasion. Science Dash C, Fisher TS, Prasad VR, Le Grice 314(5796):95–95, 2006. SFJ. Examining interactions of HIV-1 Liu Y, Borchert GL, Surazynski A, Hu reverse transcriptase with single-stranded Mechanisms of Signal CA, Phang JM. Proline oxidase activates template nucleotides by nucleoside analog Transduction both intrinsic and extrinsic pathways for interference. J Biol Chem 281(38):27873– Asano S, Park JE, Yu LR, Zhou M, apoptosis: the role of ROS/superoxides, 27881, 2006. Sakchaisri K, Park CJ, Kang YH, NFAT and MEK/ERK signaling. Oncogene Thorner J, Veenstra TD, Lee KS. Direct 25(41):5640–5647, 2006. Previously includ- Fu Z, Larson KA, Chitta RK, Parker phosphorylation and activation of a Nim1- ed as an “[Epub ahead of print]” reference. Article is now available in the print journal. SA, Turk BE, Lawrence MW, Kaldis P, related kinase Gin4 by Elm1 in budding Galaktionov K, Cohn SM, Shabanowitz yeast. J Biol Chem 281(37):27090–27098, Singh SR, Zhen W, Zheng Z, Wang H, J, Hunt DF, Sturgill TW. Identifi cation of 2006. Yin-Yang regulators and a phosphorylation Oh SW, Liu W, Zbar B, Schmidt LS, Hou SX. The Drosophila homolog of the consensus for male germ cell-associated Pellegrini M, Celeste A, Difi lippantonio human tumor suppressor gene BHD inter- Kinase (MAK)-related Kinase. Mol Cell S, Guo R, Wang WD, Feigenbaum L, acts with the JAK-STAT and Dpp signaling Biol 2006. [Epub ahead of print] - This article Nussenzweig A. Autophosphorylation at pathways in regulating male germline stem is not yet available in the print journal. serine 1987 is dispensable for murine Atm cell maintenance. Oncogene 25(44):5933– activation in vivo. Nature 443(7108):222– Experimental Therapeutics, 5941, 2006. Molecular Targets, and 225, 2006. Medical Sciences Rna: Structure, Metabolism, Chemical Biology and Catalysis Dote H, Burgan WE, Camphausen K, Baba M, Hong SB, Sharma N, Warren Lindtner S, Zolotukhin AS, Uranishi Tofi lon PJ. Inhibition of Hsp90 compro- MB, Nickerson ML, Iwamatsu A, H, Bear J, Kulkarni V, Smulevitch S, mises the DNA damage response to radia- Esposito D, Gillette WK, Hopkins RF Samiotaki M, Panayotou G, Felber BK, tion. Cancer Res 66(18):9211–9220, 2006. 3rd, Hartley JL, Furihata M, Oishi S, Zhen W, Burke TR, Jr., Linehan WM, Pavlakis GN. RBM15 binds to the RNA Genes: Structure and Regulation Schmidt LS, Zbar B. Folliculin encoded transport element RTE and provides a direct Thangaraju M, Ananth S, Martin PM, by the BHD gene interacts with a bind- link to the NXF1 export pathway. J Biol Roon P, Smith SB, Sterneck E, Prasad ing protein, FNIP1, and AMPK, and is Chem 2006. [Epub ahead of print] - This ar- PD, Ganapathy V. c/ebp delta null mouse ticle is not yet available in the print journal. Ø The NCI-Frederick Poster 9 Winter 2006–2007 Poster People Profi le: Sharon Fritz

Sharon Fritz: a real challenge,” she said, “because of providing continuous protection. Keeper of the (Card)keys building access restrictions.” “Needless to say, the access control By Nancy Parrish system saves a lot of time for Cardkey System Made everyone,” Ms. Fritz commented. Everyone knows Sharon Fritz. She’s a Difference After the tragedies of September one of the fi rst people you meet when Ms. Fritz considers the installation 11, 2001, all buildings were locked you come to work at NCI-Frederick of the cardkey system in 1984 one 24 hours a day, and all employees because she issues the identifi cation/ of the biggest improvements at had to be issued cardkeys. Ms. Fritz cardkeys. With her easy-going manner, NCI-Frederick. Before the advent of remembers long lines of employees she takes the trauma out of having waiting to have their cardkeys issued your ID picture taken, and she’ll issue or updated. “It took three days to your ID/cardkey practically before the issue all the cards,” she recalled. camera fl ash dies away. What Ms. Fritz likes best about her Renaissance Woman work is “helping customers move By her own admission, Ms. Fritz around and get where they need to was born in the wrong century. In go.” And she’s been helping people at addition to making quilts and doing NCI-Frederick for nearly 30 years in machine embroidery, she loves to the Protective Services department, garden and is especially interested fi rst as a Senior Clerk/Typist and now in native plants and daylilies, as the Access Control Coordinator. perhaps because her father had a wholesale nursery business growing Thousands of Cardkeys Maryland native plants. “I guess Ms. Fritz manages the cardkey my father gave me my passion for system on the NCI-Frederick campus. gardening,” she said, “and I have She individually programs each quite a variety of native plants.” person’s cardkey with name and She also has a koi pond built by location, plus the buildings authorized her husband and stocked with over for access. But it doesn’t stop there. 100 koi, a hobby she fi nds very As people move locations or change Sharon Fritz relaxing. “I just like to sit out by jobs, Ms. Fritz has to update their Access Control Coordinator the pond and watch the world go by,” cardkeys. With over 100 buildings Protective Services she said. When she’s not in the garden on and off campus and nearly 3,000 or sitting by the pond, she might be employees, this is no small task; Ms. playing Chopin on her grand piano or Fritz estimates she has completed electronic access systems, buildings painting a still life in oil, activities she more than 47,000 cardkey transactions were open only during business hours. wants to continue into retirement. since the system was installed nearly To access a building after hours, an 25 years ago. She has also taken employee had to sign out a key at Deep Roots in Frederick County nearly 35,000 ID photos since 1981, Protective Services, and then return it Ms. Fritz has lived in Frederick when that function was taken over when leaving. In addition, to monitor County all her life. “I left briefl y when from the Army. the scientifi c equipment, a Protective I was 18, and I couldn’t wait to get Services offi cer had to check each back,” she laughed. Many years ago, Job Grew with Facility alarm panel individually and even her parents gave her the property next One of the biggest changes Ms. Fritz manually check some pieces of door, which had been in the family for has seen over the years is the growth equipment. With the cardkey system, fi ve generations. Her roots run deep of the NCI-Frederick campus. Since people working after hours have here, and, for her, “Frederick County she began working here, the number of direct access to their buildings. Just is defi nitely home.” Her mother still employees has nearly quadrupled, and as important, now if there’s a problem lives next door, and she said, “One of the number of buildings nearly doubled. with the scientifi c equipment, the my favorite things to do is spend time This growth has had a direct impact on alarm panels fl ag the cardkey system with her. She’s my best friend and my her job. “Programming cardkeys is now in the Protective Services offi ce, biggest fan.” Ø

The NCI-Frederick Poster 10 Winter 2006–2007 Christopher J. Michejda

In Memoriam potential drug targets within these organizing the joint American stages. He pioneered the development Chemical Society’s and American Christopher J. Michejda, Ph.D. of receptor-targeted small molecule Association for Cancer Research’s toxins that selectively eliminate Chemistry in Cancer conference. tumor cells without harming healthy An exceptional mentor, Dr. Michejda tissue. This approach, now followed trained many postdoctoral fellows by many research laboratories, has and pre-doctoral and medical made possible the design of new students. As chair of the Chemistry drugs with better selectivity and low and Structural Biology Faculty, he toxicity. Most recently, together with led CCR’s efforts to establish the Dr. Nadya Tarasova, he discovered a Program in Interdisciplinary Training novel approach of shutting down the in Chemistry for postdoctoral fellows function of cell surface proteins with and graduates. He was also an active high selectivity and precision. member of several other NCI faculties The Michejda group’s pioneering and committees. work with bisimidazoacridones Dr. Michejda was a man of broad resulted in a new class of compounds knowledge and interests, including potently cytotoxic to tumor cells, language, world history, art and music. especially leukemias, liver, and Active in the United States Polish Christopher J. Michejda, Ph.D., an pancreatic cancers. His collaborative community, he organized charitable internationally recognized research work with Dr. Susan Keay, University help for political prisoners in Poland scientist and chief of the Molecular of Maryland, resulted in discovery and worked with the Washington, D.C. Aspects of Drug Design Section, of an anti-proliferative factor (APF) Committee in Support of Solidarity. Structural Biophysics Laboratory, in the bladder epithelium of patients Using his personal relationships Center for Cancer Research (CCR), who suffer from interstitial cystitis. in both the United States and died suddenly January 9 during NCI’s By identifying the elements necessary Poland, Dr. Michejda successfully annual scientifi c retreat. for APF to inhibit normal epithelial connected Solidarity leaders with With a Ph.D. in physical-organic growth, the Michejda group paved U.S. community and trade leaders, chemistry, Dr. Michejda pursued a the way for APF to be developed as a media personalities, intellectuals, postdoctoral fellowship at Harvard potent inhibitor of bladder and renal and politicians, including those at the University; was a professor of cancer. Another collaboration with Dr. White House. A staunch supporter chemistry at the University of Brian Carr, University of Pittsburgh, of human rights, Dr. Michejda was Nebraska in Lincoln; and spent a led to the discovery of a new class awarded Poland’s Knight Cross of the sabbatical in Zurich, working with of highly selective phosphatase Order of Merit. Dr. Vladimir Prelog (Nobel Laureate inhibitors that are potently active In spite of his many administrative, in Chemistry, 1975). Returning to the against hepatocellular carcinoma in academic, and research U.S., Dr. Michejda became Program animal models. responsibilities, Dr. Michejda always Director of Chemical Dynamics at Dr. Michejda published more than made time to support his wife, the National Science Foundation. 175 articles in prominent scientifi c Professor Maria Michejda, in her In 1978, he came to NCI-Frederick, journals and held 15 patents for new work on stem cell biology. In addition, fi rst focusing on the chemical therapeutic compounds or concepts. he enjoyed sharing time with his carcinogenesis of nitrosamines, and He also served as an associate editor grandchildren. then concentrating on the fundamental for Cancer Research and on the Survivors include his wife, Maria, problems involved in developing drugs editorial boards of Molecular Cancer North Potomac, Maryland; a daughter, against cancer and viral diseases, such Therapeutics; Cancer Epidemiology Monika Goodrich of Marco Island, as AIDS. Biomarkers & Prevention; and Florida; a brother, Albert Michejda Dr. Michejda’s research group at Chemical Research in Toxicology. of Winter Park, Florida; and two NCI became known for its ability to Highly respected in his fi eld, he was grandchildren, Gabriella and Andrew develop new therapies by combining an invited speaker at many local and Goodrich, also of Marco Island. Ø data from biological studies of global conferences and symposiums, disease stages with structural data on Recently, he was a key fi gure in

The NCI-Frederick Poster 11 Winter 2006–2007 Science Communications

NCI-Frederick Hosts Regional Biocommunications Meeting

NCI-Frederick played host to more on communicating effectively with Other speakers’ topics included using than 70 regional biocommunications the news media. Dr. Jeffrey Lifson, variable data printing; communicating professionals at an all-day symposium Director of the AIDS Vaccine in compliance with Section 508 of November 18 in the the Rehabilitation Act; creating Conference Center. Also co- a special exhibit for the St. sponsored by the international Louis Zoo; incorporating video BioCommunications in PowerPoint; and tagging Association and the BlueRidge and selecting keywords for Chapter of the American indexing. Dennis Biela’s Institute of Graphic Arts, capstone presentation explored the meeting was billed as a the effective use of QuickTime gathering of “Mid-Atlantic Virtual Reality. Attendees Biocommunicators” and selected four “People’s Choice” attracted scientifi c illustrators, winners from the entrants in the writers, editors, and imaging illustration and photography specialists from across Maryland competition. Two of the winners and nearby states. Volunteers were students from the Art as from Scientifi c Publications, Applied to Medicine program at Graphics and Media and the The Johns Hopkins University. Winners of the People’s Choice Competition. L to R: Conference Center organized Johns Hopkins University students Ophelia Lee and “The meeting was a great and staged the meeting. Fabian de Kok-Mercado; Cynthia Hye-Won Yoon, success,” commented Colin Cheryl Parrott, NCI- MediVisuals, Richmond, VA; Jennifer Fairman, speaker Celaya, Conference Center Frederick Director of Public and principal, Fairman Studios, Baltimore, MD. Manager and meeting General Affairs, opened the morning Chairman. “We drew more session with a history of Fort Detrick Program, delivered the keynote people than we expected, and I and NCI-Frederick, and Frank address, entitled “Facilitating the think everyone felt it was a day Blanchard, SAIC-Frederick, Inc., Effective and Artful Presentation of well spent.” Ø Director of Public Affairs, spoke Biomedical Research.”

Check It Out! Writing Aids Were you looking for information about…. Online dictionaries AlphaDictionary.com (portal to hundreds of dictionaries) Avian Infl uenza, Pandemic Infl uenza http://www.alphadictionary.com/index.shtml World Health Organization http://www.who.int/csr/disease/avian_infl uenza/en/ Stedman’s Online Medical Dictionary http://www.stedmans.com/section.cfm/45 Department of Health and Human Services (Pandemic and Avian Infl uenza) Plagiarism http://www.pandemicfl u.gov/ Ohio University, College of Arts and Sciences, ESL help (Note: this link was included in the March ’06 issue of the Poster) http://www.ohiou.edu/esl/help/plagiarism.html English for Speakers of Other Languages Language and Grammar Frederick Community College; English as a Second Language Hamilton College, Nesbitt-Johnston Writing Center courses http://www.hamilton.edu/academics/Resource/WC/index. http://www.frederick.edu/ProgramCourses/ESL/index. html cfm?documentid=313 NIH Plain Language in the Sciences English as a Second Language http://www.plainlanguage.gov/usingPL/sciences/index.cfm http://www.word2word.com/eslad.html Documentation Monroe Community College, Council of Biology Editors (CBE) Style of Documentation in Science and Mathematics http://www.monroecc.edu/depts/library/cbe.htm Ø

The NCI-Frederick Poster 12 Winter 2006–2007 Outreach and Special Programs

No Coin? Give Me Ten! access various employment Web sites By Maritta Perry Grau for work at the NCI-Frederick and other federal facilities. The students’ It’s not often that a civilian sees a teachers planned to help them develop colonel drop and give him ten, but that résumés and look at other job sites in happened at a recent Mentoring Day follow-up activities. for students with disabilities. Colonel Mary Deutsch, Installation Commander at Fort Detrick, had just given coins to the group of 18 learned about the work they might students, to commemorate their visit. do in those facilities. For example, She said Army tradition states that a when Cliff Hubbard, Charles River soldier Laboratories, took them through without the cage-washing areas (which they his or pronounced “smelly”), he explained her coin the importance of cleaning cages can be and feeding the animals to keep required them in excellent condition for Colonel Deutsch and Donald to do 10 research. Wheatley, the NCI-Frederick push-ups. After the walking tours, the Contracting Offi cer, gave the students When students ate lunch and enjoyed a certifi cates for completing the tour. one of the PowerPoint presentation about The students, 18 to 21, will graduate students landscaping, gardening, and other from local high schools this year. asked if outside work opportunities at NCI. Conducted as a cooperative effort she had The students were then given a between the NCI-Frederick Employee her coin, hands-on demonstration on how to Diversity Team and the Army’s Equal she had to Employment Opportunity Offi ce, the admit she mentoring visit was so successful that didn’t. So she immediately dropped it may be done annually. Ø and did 10 push-ups. The day began on the Fort Detrick side, where the students toured a number of USAMRIID laboratories. First they were shown “the slammer,” USAMRIID’s Biosafety Level 4 (BSL-4) patient containment suite, as well as a “space suit” like those worn in BSL-4 laboratories. They were also introduced to tarantulas and hissing cockroaches in the insectarium while learning how the military protects soldiers from insect-borne diseases. Finally, the students learned how aerosol testing is used to obtain FDA approval for drugs and vaccines to protect U.S. troops. At NCI-Frederick, the students toured the Scientifi c Library, Charles River Laboratories, the warehouse, the mail room, and the NCI-Frederick Café. At each stop, the students

The NCI-Frederick Poster 13 Winter 2006–2007 Protective Services

Chilly Today... hard to compare them because they said, practice cooking their recipe were so different: the chilis were two or three times at home before The day was chilly but the chili made with such varied ingredients creating the fi nal batch for the contest. was hot at the Protective Services’ as chocolate, coriander, black beans, Others, however, launch their maiden 4th Annual Chili Cook-off on pasta, chicken, creations on the day of the contest. December 1. Nearly 90 people and a variety came to Building 426 to of peppers and And the Winners Are… sample the 18 entries—more seasonings to This year’s top winner, Barbara than ever before—and cast provide just the Romeka of Occupational Health their vote for the top three. right “kick.” Services, said not only was it the fi rst Tom Gannon-Miller, Some attendees time she entered the cook-off, but it Manager of Protective had never tasted was also the fi rst time she made that Services, organizes the annual chili before, so particular chili (#14, White Bean event to “fi rst, have a good it was diffi cult Chicken Chili). Her beginner’s luck time.” Secondly, however, to determine earned her a 30-day reserved parking he sponsors the cook-off which ones space. Advancing from third place to gather the community’s were best. last year to second place this year input about his department. Nonetheless, was Siobhan Tierney, Environment, Attached to the chili ballot people were Health, and Safety (chili #15), who was a short survey asking quite serious won a 15-day reserved space. Third participants to rate the as they made place, a 5-day reserved space, went to services of the department their way from Bill Brady, Environment, Health, and and describe any specifi c security crockpot to crockpot. Voices were Safety, for chili #1. concerns. “If any major concerns hushed as they quietly pondered are expressed, I take them to the the nuances of fl avors they were Hope Springs Eternal Emergency Preparedness Committee,” experiencing and made notes about Mr. Gannon-Miller has been entering Mr. Gannon-Miller explained. each entry. his family chili recipe the past 4 Just as earnest were the chili masters. years, in hopes of fi nishing in the Serious Business According to Sharon Fritz, one of the top half of the pack, making minor With so many entrants, many people organizers, “These people are really adjustments each time. Better luck found it a challenge to sample all the serious about their chili.” Some, she next year, Tom. Ø chili. Others commented that it was

Barbara Romeka’s Winning Recipe: White Bean Chicken Chili

1 lb Dried Great Northern beans, picked over and rinsed 4 Garlic cloves, minced 1½ lb Skinless, boneless chicken breast halves 2 tsp Ground cumin 2 qts Chicken stock or low-sodium chicken broth 1 tsp Cayenne pepper (or to taste) 1 Tbs Olive oil 7 C Monterey Jack cheese, shredded 2 Medium onions, fi nely chopped 3–4 Jalapeno peppers, halved, seeded, coarsely chopped 2 4-oz cans chopped green chilies

Cover beans with 2 inches of water and soak overnight. Drain beans; return to pan and again cover beans with 2” of water. Bring to boil and simmer until tender (about 1 hr). Drain. Simmer chicken over low heat in 1 qt of the stock (add water to cover if needed) until just opaque throughout (about 15 min). Remove chicken and shred when cool. Boil stock over high heat until reduced to 2½ cups (about 4 min). Cook onions in oil over moderate heat until translucent. Add chilies, garlic, cumin, and cayenne, and cook, stirring, 3 min. Add beans, chicken, reduced stock, cheese, jalapenos and remaining chicken stock. Simmer 2–3 hrs until thickened. Ø

The NCI-Frederick Poster 14 Winter 2006–2007 Open House Around the Facility

Protective Services

Occupational Health Services and Protective Services both held open houses earlier this fall. The open houses showcased renovations and program improvements. Ø

Occupational Health Services

The NCI-Frederick Poster 15 Winter 2006–2007 Books for Mongolia

Making a Difference: to use English effectively and believe Books for Mongolia that have fun while reading. [The letter then lists books for Last spring, we published an students in grades 5 through 8.] article about student intern Bilguujin Those books are very useful to know Dorjsuren’s efforts to send books about all new things and other’s life to a school in her native Mongolia. especially another life of another Ms. Dorjsuren developed the project world’s people. as part of her senior graduation [Another list of books for high requirements for Governor Thomas schools students followed.] They Johnson High School in Frederick. have many useful things especially Last November, she received the CD-s, colorful illustrations and other importance to improve teaching following letter (reprinted here as materials) are very expensive and rare. method, grammar and vocabulary it appeared) and pictures from the We acknowledged those 300 English knowledge and about American and Nomuun School in Mongolia. books. These books which you sent other’s life and other peculiarities of are very useful for our training of the English language. Moreover there English. And will develop all four are 5 Japanese books with English skills (reading, writing, listening and books. Our school has a plan to open speaking) through dialogues and “Foreign language training center” everyday life’s communication words in future. So we hope these Japanese in the books. books will be useful, too. Another most important thing is to Finally we very thanked again for add new words in vocabulary box giving us so many useful books. while reading these books. Some books contain pictures relating to the books Good luck for your work! content. Of course, it’s very interesting for primary children and pupils. Our YOUR SINSERELY school’s children received them very happily, too. The headmaster of Nomuun school, Letter of the heartfelt gladness [The letter lists a number of books Mr. Uzmee.D designed for elementary-aged English teachers, From English teachers of “Nomuun” children.] Those books are very useful Myagmarsuren.B school for children to read for the fi rst time, Bolortsetseg.Ts Ø letter script is big and very interesting. Before all, Please accept that we very We think so these books enable pupils thank for you sent many English books to us. In our country English is the most important language and it is declared “English is second language of all Mongolian people” by Mongolian government. But this decision didn’t spend long time in Mongolia. It’s about for 3–4 years. Mongolian all people (from children of 5 ages to old people of 70 ages) already have known this English language’s importance. But English teachers in Mongolia have many roles and diffi culties. For example: English books and necessary things (audio and video cassettes,

The NCI-Frederick Poster 16 Winter 2006–2007 Frederick Employee Diversity Team

Diversity: “showed—controversially—that “Show Me the Money” explores Myth or Reality? ethnic and gender diversity can harm the myth that the only reason women By Maritta Perry Grau team and company performance if generally earn less than men is that they’re not managed effectively.” women are more likely to be on the True or false: The key is “if they’re not managed “Mommy track”: being diverted from effectively.” The article states that it’s careers to raise their children. The 1. Diversity is good for business. not enough to simply have ethnic and article points out that “Women with gender diversity in place: you also no kids have higher salaries than 2. Minority students would rather be need to focus on “managerial skill those who have children, but they doctors than research scientists. and organizational development…to still earn less than a man doing the address how people operate in very same job… In the life sciences 3. Women usually earn less than men organizations.” the average median salary for white for the same job because they make Another “myth” that the issue men is $80,000, compared to $72,000 detours in their careers to have and addresses is the generalization that for Hispanics, $65,000 for African raise children. minority students opt out of careers Americans, and $65,000 for women, in research for careers in medicine. according to the most recent fi gures Are these statements you’ve heard at The teaser points out that nearly all from the Commission on Professionals the lunch table? If you think they’re graduates—of all races—express an in Science and Technology.” The true, you might want to read the interest in medicine, rather than in article goes on to cite several studies November 20, 2006, online edition of science. “Shared Challenges, Shared that indicate wage disparities, “even The Scientist (20:11, s5). “Diversity: Solutions” notes that mentoring, when controlling for total publications, Some Myths, and the Realities” opportunities for research, and years of seniority, and hours worked offers several teasers that may seem hands-on experience are integral to per week.” somewhat misleading at fi rst read. successful programs to encourage You can read about these myths For example, one teaser questions minorities to stay on track for Ph.D’s. and others in The Scientist at http:// whether the maxim “Diversity is It cites reports from several symposia www.the-scientist.com/article/ good for business” is a myth to get held among 60 host institutions display/36454/. Ø you to read “Diversity: the New that explored the characteristics of Business Case.” The teaser refers successful programs. to research that The Scientist says

The Diversity Team sponsored a Mariachi band in the fall. The band strolled and strummed through the NCI-Frederick Café and the farmer’s market for nearly two hours. Ø

The NCI-Frederick Poster 17 Winter 2006–2007 New Faces at NCI-Frederick

NCI-Frederick Welcomes New Staff Sandra Zimmerman Ninety-eight people joined our Facility in July, August, and September 2006.

NCI-Frederick welcomes… Sandip Basu Sandip Basu Oyindasola Oyelaran Julie Belanger Ravindra Chalamalasetty Weizao Chen Ravi Kalathur Oyindasola Oyelaran Joshua Thomas Kyle Knott Giorgio Trinchieri Celine Walmacq Jessica Walrath Karen Wylie Ø

SAIC-Frederick, Inc., welcomes… Julie Belanger James Albert David Johnson Loralyn Walther Molly Assion Waldo Johnson Andrew Waters Kshama Aswath David Keller James Williams Ohn Aung Shelby Kenney Gaye Wilson Kimberly Bearr Kyle Knott Jeanne Yimdjo Frank Blanchard Julian Kusel Pei-Hung Yu Robert Burns Elena Kuznetsova Thomas Yu Ø Ryan Bushey Lydia Lacuesta Rocco Caldararo Julie-Anne Lanahan Ehydel Castro Sally Larson Celine Walmacq Amy Coburn Huajie Li Joseph Cogliano Jun Lu Ravindra Chalamalasetty Terri Darr Karen Martin Gaby Dasema Reggie Mose Xiang Deng Cathryn Niane Linda Dixon Kelly Nowalk Tyra Estwick Mary O’Connell Bernard Eurie Michael Orlando Andy Fisher Ravithat Putvatana Vilmarie Franco Paola Quinones-Olson Sadie Frary Erin Renshaw Cathleen Frein Anna Risse Charles River Laboratories welcomes… Brandy Gaydos Sabrina Rossi Xin Ge Daniel Rubinstein Bradley Getridge Cristian Rusu Joshua Thomas Vicky Clark Deborah Goldstein Christine Sadr William Danner Wenjuan Gu Sylvia Sanni-Thomas Michele Driver Felesha Hanga Monica Segreti M. Jane Shelton John Harshman Shaila Sharmeen Leroy Smith, Jr. Sima Hayavi Jose Sotelo Sandra Zimmerman Ø Christina Hernandez John Sparks Belynda Hicks David Sweeney Data Management Services welcomes… Rosemary Hniang Albina Toderas Jill Hudak Huong-Lan Tran Lilia Ileva Megan Turley David V. Hoberman Jeffrey Jagoda Heather Walsh Jason W. Holbert Ø

The NCI-Frederick Poster 18 Winter 2006–2007 NCI-Frederick People

Chou-Chi Li, Ph.D., Retires to use to pursue cancer therapy drugs,” by Lisa Simpson Dr. Li noted. Dr. Li added, “I am extremely thankful for having been given the opportunity to develop my research projects at NCI-Frederick. Although my research path was not always smooth, I really enjoyed it and gained tremendous life experience from the ‘ups and downs’ along the way. It was truly a pleasure to be a research scientist at NCI-Frederick.” In honor of Dr. Li’s retirement, her friends treated her to two celebrations at area restaurants. First, 30 current (L to R) Dr. William Farrar, Amy Huter-Imming, Dr. Chou-Chi Li, Dr. Nancy and former coworkers gathered at Colburn, Dr. Sandy Ruscetti, and Dr. Dolph Hatfi eld celebrate at Dutch’s Daughter restaurant. the Lotus, where the chef prepared her favorite dishes. Then, 50 friends, colleagues, and family members Chou-Chi Li, Ph.D., Head of the Persistence pays off. Dr. Li recalled enjoyed a party at Dutch’s Daughter, Protein Function Section in the a time when, during a site visit, her where, in appreciation of her many Laboratory of Cancer Prevention, proposals for two projects did not contributions to NCI-Frederick, she retired September 22, 2006, after more receive positive reviews. However, Dr. was presented with a commemorative than 23 years with NCI-Frederick. Li had faith in the projects and, with plaque, a bound anthology of her Dr. Li’s research into protein function support from Dr. Frank Ruscetti and scientifi c publications, a check, and an revealed a key player (p97/VCP) other colleagues, nurtured the projects artist’s proof of Nallin Pond by well- in the cellular protein degradation to maturity and subsequently attracted known watercolor artist Rebecca Pearl. pathway, thus shedding light on human the interest of many investigators. In Dr. Li earned her doctorate from the diseases caused by abnormal protein fact, one project developed into “a new Johns Hopkins University in 1988, accumulation. direction for pharmaceutical companies where she studied the tumorigenic effects of Human Papillomaviruses. Ø

Building 539 Animal Facility Makes a Difference

Recently, 29 employees in the Army organizers arranged Building 539 Animal Facility, private pick-ups. Laboratory Animal Sciences Program, “What a wonderful way sponsored a needy military family to help make someone’s during Fort Detrick’s “Operation Christmas a little better,” Happy Holidays,” purchasing clothes, Nancy Walsh, LASP staff toys, games, and other goods for the member, commented. “I children; food for the family; and a know other people were gift card “from” the children to the not aware of this event and parents. Even gift wrap was provided it could be a great idea for so the parents could enjoy wrapping next year.” Ø the gifts. The SAIC-Frederick, Inc., and NCI-Frederick co-workers spent three weeks gathering the gifts for delivery to the HOT Dome, where

The NCI-Frederick Poster 19 Winter 2006–2007 Poster Puzzler What is it? Where is it?

Your challenge, should you decide to accept it, is to correctly identify the item and its location from the picture to the right. Clue: It’s somewhere at Fort Detrick/NCI-Frederick. Win a framed photograph of the Poster Puzzler by e-mailing your guess, along with your name, e-mail address, and daytime phone number, to Poster Puzzler at poster@ncifcrf. gov. Alternatively, you can send us your guess, along with your name and daytime phone number on one of the Poster forms found on the front of the Poster stands in the lobbies of Buildings 426 and 549. All entries must be received by Friday, February 23, 2007, and the winner will be drawn from all correct answers received by that date.

Good luck and good hunting! Ø

The Poster Puzzler: Bull’s Eye! By Nancy Parrish

The September puzzler shows what you can do with a little practice. It is an extreme close-up of a bull’s eye in one of the four targets at the archery range located across from the pond at Nallin Farm. Judging by the stress points on the material, this shooter must have been very good. The archery range is open to all military personnel and their families, as well as to people who work on or are affi liated with the Fort Detrick post. You don’t need a reservation, and no test is required to use the range. The only regulation is that only fi eld or target points must be used; broadheads and hunting points are prohibited.

Thanks to all the participants in the September 2006 Poster Puzzler! Ø Congratulations to our September Puzzler winner: Jon Keller, a Werner H. Kirsten student intern who works in the Laboratory of Cell and Developmental Signaling. Ø

The NCI-Frederick Poster 20 Winter 2006–2007 Poster Puzzler Winner

The September Poster Puzzler winner: Jon Keller, a Werner H. Kirsten student intern who works in the Laboratory of Cell and Developmental Signaling pictured here with Paul Miller, Executive Editor of The Poster, on the archery range.Ø

The NCI-Frederick Poster 21 Winter 2006–2007 PALS’ Celebrations

The NCI-Frederick Poster 22 Winter 2006–2007 Technology Transfer Branch

Technology Transfer Length-of-service awards were SAIC, and NIH scientists and their for- Branch Staff: granted to Dr. Bjarne Gabrielsen, profi t and/or academic collaborators. It Honors and Transitions for 20 years of government service was as if I were actually a part of the with USAMRIID and NCI, and intramural laboratory programs.” By Nancy Parrish to Technology Development Over the years, Dr. Gabrielsen has Administrative Specialist Chris observed that research has become Sappington for 10 years of service. more collaborative, as evidenced by Mr. Sappington joined the Frederick the number of NCI/SAIC-Frederick, offi ce of the TTB in 2005, following Inc., collaborations with extramural nine years at the NIH Clinical Center entities, USAMRIID, and with other in Bethesda, where he worked as NIH institutes such as NIAID. He an administrator in the nursing commented that “scientists themselves department and the Department of have become much more conscious Clinical Research Informatics. of the benefi ts…of technology transfer and protection of intellectual Dr. Bjarne Gabrielsen Retires property through the licensing of their Dr. Bjarne Gabrielsen, Senior inventions and the potential royalties TTB Staff Honored at Advisor at the TTB in Frederick, gained thereby.” Awards Ceremony retired after nearly 15 years with Career highlights include negotiating the National Cancer Institute. agreements between NCI and foreign Four members of the Frederick countries and their institutions to offi ce of the NCI Technology Transfer obtain and screen samples from Branch (TTB) were honored at the their biodiversity for developing NCI Director’s Awards ceremony held new drug therapies; helping identify October 25 at the National Institutes of potential therapeutic agents, “thus Health (NIH) in Bethesda. aiding NCI, NIH, the general public, Dr. Jeff Thomas, a TTB senior and especially the source countries advisor, participates on the NCI and their scientists”; and being Biospecimen Coordination Committee, named NCI/NIH representative to a which earned an NIH Award of Merit committee created “to establish and for developing best practices guidelines enhance scientifi c collaborations and for acquiring, storing, and tracking exchanges of scientifi c personnel high-quality biospecimens in cancer between Norway, Canada, and the biorepositories. “It’s very gratifying U.S.” He appreciates each time to be recognized for your work,” Dr. Dr. Gabrielsen fi rst worked at NCI- he received personal thanks from Thomas commented, “especially when Frederick as Assistant Project Offi cer “scientists with whom I had interacted, you look around at all the incredible for the Research Support Services, and whose expertise I respect” and things being done at NCI.” Dr. which provided biological/chemical also appreciates the collegiality he had Melissa Maderia, Technology Transfer services to NCI and NIH scientists with his fellow scientists, as well as Specialist, is part of the Center for in Frederick and Bethesda. In 1997, the TTB’s “supportive and stimulating Cancer Research–Fellows and Young because of his expertise in organic environment.” Investigators (CCR-FYI) steering chemistry and natural products and his Following two months as a special committee, which also received an interest in technology transfer issues, volunteer, Dr. Gabrielsen will move to NIH Merit Award. for “outstanding Dr. Gabrielsen was recruited to the Florida, where he will spend high- effort in planning and implementing TTB in Rockville as a Senior Advisor, quality time with his family, fi sh in the CCR-FYI Annual Retreat,” which Drug Discovery/Development. the Gulf of Mexico, and devote time drew approximately 500 attendees. Dr. Gabrielsen found his new to composing and arranging music, a Dr. Maderia was pleased that the position gratifying, he said, because lifelong avocation. He also anticipates committee’s efforts to “ensure that NCI “I could play a more active role in exchanging seasonal visits with his remains a premier institute for young actually facilitating and safeguarding Norwegian family. Ø scientists” were recognized. research collaborations involving NCI,

The NCI-Frederick Poster 23 Winter 2006–2007 Charles River Laboratories

were chosen from makes it clear that these animals are Charles River’s always her fi rst priority. U.S. facilities Lise has been an integral part of the to receive this NCI-Frederick Take Your Child to prestigious Work Day (TYCTWD) for the last award. fi ve years. She is the APA/Charles Lise has River Laboratories representative on supervised the planning committee, but she also more than 21 organized popular sessions in which employees for the children got to work in an isolator, last 12 years and see litters of mice of different ages, has been praised and learn how mice are cared for. by her staff as The program was so popular that New CRL Building a top-notch supervisor. As noted by one individual, Charles River Corporate sponsored “Lise cares deeply for her a picnic at Nallin Pond in September employees as people, not to celebrate the new 10-year just bodies to get the job contract awarded to Charles River done.” Other employees Laboratories. Linda Blumenauer, complimented Lise for the Project Offi cer for the Animal her strong devotion to the Production Area (APA) contract, gave company’s biosecurity, a presentation of what is happening in which is necessary for the government and the importance of raising pathogen-free the new building that is scheduled to rodents; for writing and be built in the next two years. Ø implementing standard operating procedures for the Lise DeVore Honored Isolator Production Unit; for her open-minded attitude toward change, especially if the change helps employees do a better job; and for getting questions answered and problems solved quickly. Her personal interaction with her staff is also appreciated. When an employee was seriously hurt in a car accident, Lise updated Lise encouraged the barrier groups Lise DeVore, Supervisor of the her group daily on his progress. to develop a similar program for Isolator Production Unit at the Lise greets her group with a “good TYCTWD. APA/Charles River Laboratories, morning” call and is in the Isolator As written in the letter that received a Charles River Laboratories Unit daily. She always goes the extra accompanied her award, “If there is Exceptional Employee Award for step: when special orders for animals a person that should be recognized 2006. Lise was nominated by her are being shipped from the Isolator for his award, that one should be Lise staff for this award. There were Unit, her group knows that she will DeVore. We would like to thank her 475 nominations submitted from personally review these orders for for the tremendous job she has done, Charles River’s U.S. facilities for all accuracy prior to shipment. With a and is still doing. [She is] a very categories, with 174 nominated for no-nonsense attitude about the welfare great asset to the APA/Charles River the Exceptional Employee Award of the laboratory animals raised at the Laboratories.” Ø category. From these 174, only 43 APA/Charles River Laboratories, she

The NCI-Frederick Poster 24 Winter 2006–2007 Data Management Services (DMS)

Data Management Computer Software Training Services: Computers and Statistical Support The fall 2006 training session is underway. Classes are now being held in the new C&SS training room located in Building 362. Please see the Computer Software Training Web site at http://css.ncifcrf.gov/training for more Although perhaps most widely information or to register for classes. Ø known for our Microcomputer Support and Web Development services, C&SS also offers many other services to the NCI-Frederick community. Listed here are some of these other services. Statistical Consultation The Statistical Consultation group provides a wide array of mathematical and statistical consulting services to the NCI-Frederick scientifi c community. The director and consulting statisticians work in collaboration New C&SS training room with principal investigators through in Building 362. all facets of the scientifi c process: from development and formulation of research and statistical hypotheses through design of experiments and statistical analyses, preparation of technologies that could benefi t the Helpdesk, visit the C&SS Web site technical reports and modern graphics, user community and further NCI- at: http://css.ncifcrf.gov/helpdesk/ to preparation of formal scientifi c Frederick’s mission. C&SS staff would software.asp or contact the Computer documents and publications in peer- be happy to meet with you to discuss Services Helpdesk to borrow the reviewed journals. Ø your specifi c technology needs. Ø software or request installation assistance. Ø Custom Software Development Computer Services Helpdesk Our team of analysts and developers The Computer Services Helpdesk employs the most modern methods provides the NCI-Frederick and tools to create custom software community with a single point of Contacting C&SS solutions to meet the unique needs contact for computer assistance, Computer Services Helpdesk and requirements of NCI-Frederick. information, service, and support. The Web: http://css.ncifcrf.gov/helpdesk Our staff can assist you with Helpdesk is staffed from 8:00 a.m. to E-mail: [email protected] both administrative and scientifi c 5:00 p.m., Monday through Friday, Phone: 301-846-5115 programming needs, as well as Web excluding NCI-Frederick holidays. design and development services. Requests for service can also Hours of Operation: Visit the C&SS Web site at http:// be placed via the C&SS Web site 8:00 a.m.–5:00 p.m., css.ncifcrf.gov or call 301-846- (http://css.ncifcrf.gov/helpdesk) at Monday through Friday 1060 for information about custom any time. Ø development services available from NCI-Frederick Webmasters C&SS. Ø Site-Licensed Software Phone: 301-846-6700 Available from the Helpdesk! E-mail: [email protected] Technology Advocacy and C&SS, in conjunction with the NCI, [email protected] Consultation has worked to secure site licenses for As NCI-Frederick’s information many of the programs in broad use at Other Inquiries technology experts, C&SS continually NCI-Frederick. To view the growing Phone: 301-846-1060 Ø explores and evaluates new list of software available from the

The NCI-Frederick Poster 25 Winter 2006–2007 SAIC-Frederick, Inc.

BDP Makes a Difference! The “For Phil” team comprised Mr. Rothchild’s wife, Marion; Whether it’s producing and studying the effects of various drugs or teaming up his daughter, son-in-law, and outside the workday, the Biopharmaceutical Development Program (BDP) staff granddaughter, Jill, Michael, and makes a difference: reaching out with their talent and time to improve others’ lives. Farah Goldman; family friends Marilyn Ohring, Stacey Shenker and her daughter, Elyssa, and Sara Weiser; BDP friends Judy Duears, Kathy Miller (team captain), Vonnie Hill, Patty Green, Deena Wisner, Carla Bryant; and friend Fran Hostetler, manager of the Café NCI-Frederick. The team raised $2,960 in sponsorship contributions and was among the top fi ve fundraisers for the Frederick County Walk. Ø

Making Holidays a Little Cheerier for Troops in Iraq that the Shoebox Drive received from SAIC-NCI was exceptional: “The In November, BDP staff collected Marine Corps Key Volunteer Network all sorts of items to be packaged and was able to send over 300 item sent to Marine troops in Iraq. They packed shoe boxes to Iraq, largely fi lled both a van and a car with items due to the support of the Fort Detrick for personal care and hygiene, chap Community. More proof positive sticks, hand warmers and sanitizers, that when our service members have baby wipes, disposable razors, books a need, there are no organization and magazines, wrapped hard candies, boundaries on our installation. Army cheese and peanut butter cracker Community Service feels very packages, strong toilet paper. fortunate to be able to partner with The Army Volunteer Corps had NCI on projects that touch so many also asked for empty shoebox-size lives.” Ø boxes and mailing tape to package the Raising Diabetes Awareness Several members of the “For Phil” gifts for mailing. All items had to be team at the beginning of the Diabetes small enough to fi t into the soldiers’ Did you know that more than 20 Walk. From L to R: Vonnie Hill, Marilyn backpacks. million Americans have diabetes, and Ohring, Marion Rothchild, Sarah Weiser “The donations were requested on nearly one-third don’t even realize (peering over Marion’s shoulder), behalf of a unit of soldiers in Iraq it? To make people more aware, the Michael Goldman, Jill Goldman, and whose duty it is to guard a dam,” said American Diabetes Association (ADA; Stacey Shenker. Youngest members Farah event organizer Brenda Chasteen. http://www.diabetes.org/home.jsp.) Goldman (L) and Elyssa Shenker (R) “The Army/Marines had a goal of annually sponsors a 5K run/walk/ participated by stroller. sending 108 boxes, but due to the ride event, raising funds for diabetes very generous donations of the BDP, research, education, and advocacy. they were able to send 350 boxes.The In October, friends and family of the Army/Marines wanted you to know late Phil Rothchild, BDP’s Business they really appreciated your generosity Operations Director who died last and to extend a huge ‘Thanks.’” July of complications from diabetes, Towanda Stockton, Army Volunteer participated in the 2006 America’s Corps Coordinator, said the support Walk for Diabetes.

The NCI-Frederick Poster 26 Winter 2006–2007 Wilson Information Services Corporation (WISCO)

Book and Media Swap Center was presentations and play them back via Highlights Ben Franklin festooned the Web. Don’t hesitate to call 301- with kites, 846-5840 and let us know how the The October Book and Media symbolic library can help you share your work Swap has become a traditional part of his early with others. Ø of the Scientifi c Library’s month- experiments long celebration of National Medical with Staff Commemoration Librarians Month. Because this year electricity. Congratulations go to Library Aide marked the 300th anniversary of In the fi rst Jolaina Page, who recently celebrated Benjamin Franklin’s birth in 1706, it hour alone, her fi ve-year anniversary. Ø seemed only fi tting to commemorate more than his accomplishments as the focal 1,200 items point for the celebration. For example, were swapped, and by the end of the “The rapid progress true science now did you know that: day, the grand total came to nearly makes occasions my regretting some- 1,700 items. The library collected times that I was born so soon.” • Ben opened the fi rst free lending more items than in any previous year, — Benjamin Franklin, in a letter to library; with mystery/thriller titles in the top Joseph Priestly, 1780 Ø • In addition to being one of our category. Outgoing favorites this year country’s Founding Fathers, Ben were science fi ction/fantasy titles. was a scientist, inventor, musician, Curiously, many people asked library publisher, author, politician, and staff what was going on, an indication The Amazing Life Of diplomat; that not everyone knows about the Ben Franklin • Ben proposed daylight savings time swap. So please tell your co-workers The library invites readers to take advantage of its new resources describing 150 years before the practice was to save their books, CDs, DVDs, and the amazing life of Ben Franklin. Here is adopted; cassettes for next year’s event on a selection: • Ben encouraged the circulation of October 8. The more, the merrier! Ø • The Autobiography of Benjamin fresh air to fi ght disease 100 years Franklin, by Benjamin Franklin before Louis Pasteur; Technology Training Lab Update: Practice Your Book; Call No. WZ 100 .F831 1964 • Ben discovered the Gulf Stream • The Ben Franklin Book of Easy and while crossing the ocean in his Presentation in the Technology Incredible Experiments, edited by Lisa travels between the United States Training Lab Jo Rudy Book; Call No. Q 182.3 .B456 1995 and Europe; and Have a big presentation coming up? • Benjamin Franklin, by Edmund S. • Ben invented hot air balloons, and Now you can practice—and record— Morgan bifocals (for which most of us over your presentation in a quiet space Book; Call No. WZ 100 .M827 2002 50 express profound gratitude)? before “going live.” The Scientifi c • Benjamin Franklin: An Extraordinary Library’s Technology Training Lab is Life, An Electric Mind, by Walt Disney Entertainment In tribute to this true Renaissance available on a fi rst come, fi rst served DVD; Call No. AV 00201 no.21 man, the lobby of the Conference basis to anyone who would like to • Doctor Franklin’s Medicine, by Stanley practice or record his Finger or her presentation. Book; Call No. WZ 100 .F497 2006 Whether you are • The First Scientifi c American: Benjamin Franklin and the Pursuit of preparing to face Genius, by Joyce E. Chaplin your fi rst audience Book; Call No. WZ 100 .C464 2006 or your hundredth, • National Treasure; Science in the being able to see Cinema Series yourself on fi lm is a DVD; Call No. AV 00201 no.21 great way to improve • Poor Richard’s Almanack, by Benjamin Franklin your performance. Book; Call No. WZ 309 .F831 1980 The library also • The Wit & Wisdom of Benjamin now offers the Franklin, by James C. Humes capability to record Book; Call No. WZ 309 .E921 2001 Ø

The NCI-Frederick Poster 27 Winter 2006–2007 The Poster Staff Employment Opportunities Executive Editor Paul Miller Associate Editor Please contact the individual contractor’s human resources Ken Michaels representatives or go to the contractor’s Web site for Managing Editor up-to-date, detailed information about jobs or research Maritta Grau and training opportunities and requirements. Co-Editor Nancy Parrish Production Editor Charles River Laboratories Kathy Green http://www.criver.com Lead Designer Tammy Schroyer Photography Editors Data Management Services Jonathan Summers Marti Welch http://css.ncifcrf.gov/about/dms.htm Contributing Editors National Cancer Institute at Frederick Administrative Resource Center http://www.training.nih.gov/postdoctoral Debbie Dixon Judi Carter Tanya Sappington SAIC-Frederick, Inc. Charles River Laboratories Cliff Hubbard http://saic.ncifcrf.gov Community Outreach www.saic.com Barbara Birnman Julie Hartman Data Management Services Wilson Information Services Corporation Stephanie Sheppard http://www-library.ncifcrf.gov Facilities Maintenance and Engineering Deborah Dobbe Environment, Health, and Safety Program Alberta Peugeot Upcoming Events and Dates to Note Frederick Employee Diversity Team Presidents’ Day: February 19, 2007 Scott Keimig Fisher BioServices Scientifi c Writing Workshop: April 16, 18, and 20, 2007 Kathleen Groover Patricia Hindes Eleventh Annual NCI-Frederick/Ft. Detrick Spring Research Festival: SAIC-Frederick, Inc. May 16–17, 2007 Dave Bufter Armed Forces Day: May 19, 2007 Science Today Paul Nisson Wilson Information Services Corporation Sue Wilson Robin Meckley Reminder: When you have a change in staff, such as new staff, a promotion, retirement, loss of staff, be sure to change the information on the NCI-Frederick database. You can do this online by Published four times a year by Scientifi c logging on to http://web.ncifcrf.gov/campus/phonebook/, or by contacting your human resources Publications, Graphics & Media for the National Cancer Institute at Frederick, representative. For more information, you may refer to the inside front cover of the NCI-Frederick Frederick, MD 21702. Telephone & Services Directory. http://web.ncifcrf.gov/ThePoster Comments or suggestions for The Poster may be directed to http://web.ncifcrf.gov/ThePoster

The National Cancer Institute at Frederick

Frederick, MD 21702-1201 Weather Advisory

You peer out the bedroom window and see softly falling snow or the gleam of ice. Is the base closed? Here’s how to fi nd out. Call the Fort Detrick Telenews (301-619-7611), or listen to local radio/television stations for information.

Closing or Delayed Opening Remember: When Fort Detrick is closed, NCI-Frederick is also closed; when Fort Detrick has a delayed opening, NCI- Frederick has a delayed opening. NCI-Frederick does not follow weather closing or delayed opening advisories for the NIH-Bethesda campus or Washington metropolitan area.

Early Dismissal For early dismissal, NCI-Frederick operates independently of Fort Detrick; therefore, your supervisor will notify you if NCI-Frederick closes during work hours.

Who Ya Gonna Call?

Telephone Recorded weather line 301-619-7611 Ft. Detrick toll free number 1-800-256-7621, *8, 37611# TDD 301-619-2293

Internet (This will only be used if there is a change in operating hours.) Fort Detrick’s home page: http://www.detrick.army.mil/. Weather information pops up automatically. Ø

Radio/TV

Frederick, MD Chambersburg, PA Washington, DC WAFY FM/103.1 WHGT AM/1590 WGMS FM/104.1 WFMD AM/930 WMZQ FM/98.7 WFRE FM/99.9 Gettysburg, PA WRQX FM/107.3 WTOP AM/820 WGET AM/1320 WTOP FM/103.5 WGTY FM/107.7 WWTP AM/1500 and FM/107.7 Hagerstown, MD WUSA TV/Channel 9 Ø WARK AM/1490 Mercersburg, PA WJEJ AM/1240 WSRT FM/92.1 WQCM FM/96.7 WWEG FM/106.9 Greencastle, PA WHAG TV/Channel 25 WAYZ FM/104.7 WWMD FM/101.5 Baltimore, MD WBAL AM/1090 Martinsburg, WV WCAO AM/600 WEPM AM/1340 WIYY FM/97.9 WICL FM/95.9 WPOC FM/93.1 WLTF FM/97.5

Thurmont, MD Charles Town, WV WTHU AM/1450 WMRE AM/1550

Williamsport, MD WCRH FM/90.5 NCI-Frederick Annual Halloween Contest