Les Intoxications Végétales Chez Le Cobaye (Cavia Porcellus). Thèse D'exercice, Ecole Nationale Vétérinaire De Toulouse – ENVT, 2018, 224 P

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Les Intoxications Végétales Chez Le Cobaye (Cavia Porcellus). Thèse D'exercice, Ecole Nationale Vétérinaire De Toulouse – ENVT, 2018, 224 P OATAO is an open access repository that collects the work of Toulouse researchers and makes it freely available over the web where possible This is an author’s version published in: http://oatao.univ-toulouse.fr/ 25418 To cite this version: Moraldi, Tiphanie . Les intoxications végétales chez le cobaye (Cavia Porcellus). Thèse d'exercice, Ecole Nationale Vétérinaire de Toulouse – ENVT, 2018, 224 p. Any correspondence concerning this service should be sent to the repository administrator: [email protected] ANNEE 2018 THESE : 2018 – TOU 3 – 4125 LES INTOXICATIONS VEGETALES CHEZ LE COBAYE (CAVIA PORCELLUS) _________________ THESE pour obtenir le grade de DOCTEUR VETERINAIRE DIPLOME D’ETAT présentée et soutenue publiquement devant l’Université Paul-Sabatier de Toulouse par MORALDI Tiphanie Née, le 21/11/1991 à MARSEILLE (13) ___________ Directeur de thèse : Mme Nathalie PRIYMENKO ___________ JURY PRESIDENT : M. Claude MOULIS Professeur à l’Université Paul-Sabatier de TOULOUSE ASSESSEURS : Mme Nathalie PRIYMENKO Maître de Conférences à l’Ecole Nationale Vétérinaire de TOULOUSE M. Guillaume LE LOC’H Maître de Conférences à l’Ecole Nationale Vétérinaire de TOULOUSE Ministère de l'Agriculture et de l’Alimentation ECOLE NATIONALE VETERINAIRE DE TOULOUSE Directrice : Madame Isabelle CHMITELIN PROFESSEURS CLASSE EXCEPTIONNELLE Mme CHASTANT-MAILLARD Sylvie, Pathologie de la Reproduction M. BOUSQUET-MELOU Alain, Physiologie et Thérapeutique Mme CLAUW Martine, Pharmacie-Toxicologie M. CONCORDET Didier, Mathématiques, Statistiques, Modélisation M DELVERDIER Maxence, Anatomie Pathologique M. ENJALBERT Francis, Alimentation M. PETIT Claude, Pharmacie et Toxicologie M. SCHELCHER François, Pathologie médicale du Bétail et des Animaux de Basse-cour PROFESSEURS 1° CLASSE M. BAILLY Jean-Denis, Hygiène et Industrie des aliments M. BERTAGNOLI Stéphane, Pathologie infectieuse M. BERTHELOT Xavier, Pathologie de la Reproduction M. BRUGERE Hubert, Hygiène et Industrie des aliments d'Origine animale Mme CADIERGUES Marie-Christine, Dermatologie Vétérinaire M. DUCOS Alain, Zootechnie M. FOUCRAS Gilles, Pathologie des ruminants Mme GAYRARD-TROY Véronique, Physiologie de la Reproduction, Endocrinologie M GUERIN Jean-Luc, Aviculture et pathologie aviaire Mme HAGEN-PICARD, Nicole, Pathologie de la reproduction M. JACQUIET Philippe, Parasitologie et Maladies Parasitaires M. LEFEBVRE Hervé, Physiologie et Thérapeutique M. MEYER Gilles, Pathologie des ruminants M. SANS Pierre, Productions animales Mme TRUMEL Catherine, Biologie Médicale Animale et Comparée PROFESSEURS 2° CLASSE Mme BOULLIER Séverine, Immunologie générale et médicale Mme BOURGES-ABELLA Nathalie, Histologie, Anatomie pathologique M. GUERRE Philippe, Pharmacie et Toxicologie Mme LACROUX Caroline, Anatomie Pathologique, animaux d’élevage Mme LETRON-RAYMOND Isabelle, Anatomie pathologique M. MAILLARD Renaud, Pathologie des Ruminants M. MOGICATO Giovanni, Anatomie, Imagerie médicale PROFESSEURS CERTIFIES DE L'ENSEIGNEMENT AGRICOLE Mme MICHAUD Françoise, Professeur d'Anglais M SEVERAC Benoît, Professeur d'Anglais MAITRES DE CONFERENCES HORS CLASSE M. BERGONIER Dominique, Pathologie de la Reproduction Mme DIQUELOU Armelle, Pathologie médicale des Equidés et des Carnivores M. JAEG Jean-Philippe, Pharmacie et Toxicologie Mise à jour au 07/09/2018 M. JOUGLAR Jean-Yves, Pathologie médicale du Bétail et des Animaux de Basse-cour M. LYAZRHI Faouzi, Statistiques biologiques et Mathématiques M. MATHON Didier, Pathologie chirurgicale Mme MEYNADIER Annabelle, Alimentation Mme PRIYMENKO Nathalie, Alimentation M. RABOISSON Didier, Productions animales (ruminants) M. VERWAERDE Patrick, Anesthésie, Réanimation M. VOLMER Romain, Microbiologie et Infectiologie MAITRES DE CONFERENCES (classe normale) M. ASIMUS Erik, Pathologie chirurgicale Mme BENNIS-BRET Lydie, Physique et Chimie biologiques et médicales Mme BIBBAL Delphine, Hygiène et Industrie des Denrées alimentaires d'Origine animale Mme BOUCLAINVILLE-CAMUS Christelle, Biologie cellulaire et moléculaire Mme BOUHSIRA Emilie, Parasitologie, maladies parasitaires M. CONCHOU Fabrice, Imagerie médicale M. CORBIERE Fabien, Pathologie des ruminants M. CUEVAS RAMOS Gabriel, Chirurgie Equine Mme DANIELS Hélène, Microbiologie-Pathologie infectieuse Mme DAVID Laure, Hygiène et Industrie des aliments Mme DEVIERS Alexandra, Anatomie-Imagerie M. DOUET Jean-Yves, Ophtalmologie vétérinaire et comparée Mme FERRAN Aude, Physiologie Mme LALLEMAND Elodie, Chirurgie des Equidés Mme LAVOUE Rachel, Médecine Interne M. LE LOC’H Guillaume, Médecine zoologique et santé de la faune sauvage M. LIENARD Emmanuel, Parasitologie et maladies parasitaires Mme MEYNAUD-COLLARD Patricia, Pathologie Chirurgicale Mme MILA Hanna, Elevage des carnivores domestiques M. NOUVEL Laurent, Pathologie de la reproduction (en disponibilité) Mme PALIERNE Sophie, Chirurgie des animaux de compagnie Mme PAUL Mathilde, Epidémiologie, gestion de la santé des élevages avicoles et porcins M. VERGNE Timothée, Santé publique vétérinaire – Maladies animales règlementées Mme WARET-SZKUTA Agnès, Production et pathologie porcine MAITRES DE CONFERENCES CONTRACTUELS Mme BORDE DORE Laura, Médecine interne des équidés M. LEYNAUD Vincent, Médecine interne ASSISTANTS D'ENSEIGNEMENT ET DE RECHERCHE CONTRACTUELS Mme BLONDEL Margaux, Chirurgie des animaux de compagnie M. CARTIAUX Benjamin, Anatomie-Imagerie médicale M. COMBARROS-GARCIA Daniel, Dermatologie vétérinaire Mme COSTES Laura, Hygiène et industrie des aliments M. GAIDE Nicolas, Histologie, Anatomie Pathologique M. JOUSSERAND Nicolas, Médecine interne des animaux de compagnie Mise à jour au 07/09/2018 REMERCIEMENTS A Monsieur le Professeur Claude MOULIS Professeur Emérite de la Faculté de Pharmacie de Toulouse Pour m’avoir fait l’honneur d’accepter la présidence de ce jury de thèse Remerciements et hommages respectueux. A Madame le Docteur Nathalie PRIYMENKO Maître de Conférences de l’Ecole Nationale Vétérinaire de Toulouse Alimentation et nutrition Pour avoir accepté d’être ma directrice de thèse, vos conseils et pour le temps passé à corriger ce travail Veuillez trouver ici l’expression de ma reconnaissance et de mon profond respect. A Monsieur le Docteur Guillaume LE LOC’H Maître de Conférences de l’Ecole Nationale Vétérinaire de Toulouse Médecine zoologique et santé de la faune sauvage Pour m’avoir fait l’honneur de participer à ce jury de thèse Veuillez trouver ici l’expression de mes sincères remerciements. A Madame le Docteur Jennifer BLONDEAU Docteur vétérinaire Chef de projet au Centre National d'Informations Toxicologiques Vétérinaires (CNITV) Pour avoir accepté de m’aider sur ce travail, pour le temps que vous m’avez consacré et pour vos explications Veuillez trouver ici l’expression de toute ma gratitude. 5 6 SOMMAIRE Abréviations ............................................................................................................................. 10 Table des illustrations ............................................................................................................... 11 Liste des diagrammes ........................................................................................................... 11 Liste des figures .................................................................................................................... 11 Liste des graphiques ............................................................................................................. 12 Liste des tableaux ................................................................................................................. 13 Introduction .............................................................................................................................. 15 PARTIE I - Les cas décrits d’intoxication végétale spontanée chez le cobaye ................. 17 1. Etat des lieux des intoxications végétales chez le cobaye en France depuis 1984 : données du CNITV ............................................................................................................... 19 1.1. Présentation du CNITV ...................................................................................... 19 1.2. Précisions sur l’obtention des données et sur le lexique utilisé ......................... 19 1.3. Appels reçus au CNITV depuis 1984 impliquant le cobaye .............................. 20 1.3.1. Répartition générale des appels concernant des cobayes ............................... 20 1.3.2. Répartitions des intoxications probables et certaines d’origine végétale chez le cobaye ............................................................................................................. 24 1.3.2.1. Plantes en cause dans les intoxications des cobayes ................................... 25 1.3.2.2. Mortalité et intoxication végétale chez les cobayes .................................... 27 2. Les cas d’intoxication végétale spontanée décrits dans la littérature ........................ 31 2.1. Cas d’intoxication lors d’ingestion de fleur de lune et de philodendron............ 31 2.2. Cas d’intoxication lors d’ingestion de feuille de laurier rose ............................. 33 2.3. Cas d’intoxication lors d’ingestion de ray-grass contaminé par de l’ergot de seigle ............................................................................................................................ 35 7 PARTIE II - Les intoxications végétales chez le cobaye, animal de laboratoire .............. 37 Généralités ...........................................................................................................................
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