ACVR2B Recombinant Cat. No.: 96-009

ACVR2B Recombinant Protein

Specifications

SPECIES: Human

SOURCE SPECIES: HEK293 cells

SEQUENCE: Ser 19 - Thr 137

FUSION TAG: C-His Tag

TESTED APPLICATIONS: WB

APPLICATIONS: This recombinant protein can be used for WB. For research use only.

PREDICTED MOLECULAR 14.5 kDa WEIGHT:

Properties

PURITY: >97% as determined by SDS-PAGE.

PHYSICAL STATE: Lyophilized

BUFFER: PBS, pH7.4

Lyophilized Protein should be stored at -20˚C or lower for long term storage. Upon STORAGE CONDITIONS: reconstitution, working aliquots should be stored at -20˚C or -70˚C. Avoid repeated freeze-thaw cycles.

September 27, 2021 1 https://www.prosci-inc.com/acvr2b-recombinant-protein-96-009.html Additional Info

OFFICIAL SYMBOL: ACVR2B

ALTERNATE NAMES: ACVR2B, ACTRIIB, MGC116908

ACCESSION NO.: NP_001097

GENE ID: 93

Background and References

Activin receptor type-2B (ACVR2B) is also known as ActR-IIB and MGC116908, ACVR2B is an activin type 2 receptor. Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling . Activins signal through a heteromeric complex of receptor serine which include at least two type I (I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a BACKGROUND: cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling; and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in of type I receptors by type II receptors. Type II receptors are considered to be constitutively active kinases. This encodes activin A type IIB receptor, which displays a 3- to 4-fold higher affinity for the ligand than activin A type II receptor. Defects in ACVR2B are the cause of visceral heterotaxy autosomal type 4 (HTX4).

REFERENCES: 1) Attisano, L. et al., 1996, Mol. Cell. Biol. 16: 1066-1073.

2) Woodruff, T.K., 1998, Biochem. Pharmacology 55:953.

ANTIBODIES FOR RESEARCH USE ONLY.

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September 27, 2021 2 https://www.prosci-inc.com/acvr2b-recombinant-protein-96-009.html