CG4468 CG1561 CG13077 PIP82 msta ninaC chaoptic CG4979 oxidoreductase Rab-RP1 Rhodopsin 5 Rhodopsin 4 Rhodopsin 3 ninaE trp-like trp G (Transducin) G inaC inaF inaD Arrestin 2 Arrestin 1 Gene g b 76 30A C Unknown Unknown Unknown Unknown, expressed in photoreceptor cells Unknown, expressed in photoreceptor cells kinase Deactivation of rhodopsin-mediated signaling, calmodulin-binding serine/threonine Extracellular membrane glycoprotein, mediates homophilic photoreceptor cell adhesion Phosphatidylserine-specific phospholipase A1 Short-chain dehydrogenase/reductase, implicated in repulsive axon guidance Rab-like GTPase involved in intracellular signaling Blue-sensitive in R8, mediates G-protein-coupled signaling UV-sensitive opsin in R7, mediates G-protein-coupled signaling UV-sensitive opsin in R7-8, mediates G-protein-coupled signaling Long-wave sensitive opsin in R1-R6, mediates G-protein-coupled signaling Light-activated voltage-gated Ca Light-activated voltage-gated Ca Heterotrimeric G-protein GTPase involved in rhodopsin-mediated signaling Deactivation of rhodopsin-mediated signaling, Deactivation of rhodopsin-mediated signaling, Diacylglycerol-binding Deactivation of rhodopsin-mediated signaling Deactivation of rhodopsin-mediated signaling with the G-protein, transducin Deactivation of rhodopsin-mediated signaling, disrupts the interaction Rhodopsin with the G-protein, transducin Deactivation of rhodopsin-mediated signaling, disrupts the interaction Rhodopsin Molecular Function 2+ 2+ channel channel DOWN- UP PATTERN b -subunit of heterotrimeric G-protein GTPase protein kinase C Unknown Unknown Unknown Unknown Unknown reduced Rhodopsin levels. Defect. Rhod-mediated signaling, Rhabdomeres highly deranged Unknown Unknown Unknown Defect. Rhod-mediated signaling Defect. Rhodopsin-mediated signaling Defect. Rhod-mediated signaling rhabdomere degen. Defect. Rhod-mediated signaling, Defect. Rhod-mediated signaling, eye degen. Defect. Rhod-mediated signaling, eye degen. Unknown Light-dependent eye degeneration Defect. Rhodopsin-mediated signaling Defect. LAVG Ca Light-dependent eye degeneration Light-dependent eye degeneration Light-dependent eye degeneration Mutant Phenotype Supplementary Fig.3. Talylor et al 2+ channel function